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30 studies found for:    "multiple system atrophy" | Open Studies
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Rank Status Study
1 Recruiting Oligomeric Alpha-synuclein in Multiple System Atrophy
Condition: Multiple System Atrophy (MSA)
Intervention:
2 Recruiting PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK
Conditions: Progressive Supranuclear Palsy (PSP);   Corticobasal Degeneration;   Multiple System Atrophy (MSA)
Intervention:
3 Recruiting Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patients With MSA
Condition: Multiple System Atrophy
Interventions: Drug: L-Threo DOPS;   Drug: placebo
4 Recruiting Sporadic Degenerative Ataxia With Adult Onset: Natural History Study
Condition: Late Onset Sporadic Cerebellar Ataxia
Intervention:
5 Recruiting Water and Sudafed in Autonomic Failure
Conditions: Shy-Drager Syndrome;   Multiple System Atrophy
Interventions: Drug: Pseudoephedrine + 480 ml water;   Drug: Pseudoephedrine + 50 ml water;   Other: Placebo + 480 ml water (optional);   Other: Placebo + 50 ml water (optional)
6 Recruiting Biomarkers in Parkinsonian Syndromes
Conditions: Parkinsonian Syndromes;   Parkinson's Disease;   Multiple System Atrophy;   Progressive Supranuclear Palsy
Interventions: Other: CSF, blood and urine sampling;   Other: clinical measures of disease severity and progression
7 Recruiting Norepinephrine Transporter Blockade, Autonomic Failure
Condition: Multiple System Atrophy (MSA)
Interventions: Drug: Atomexetine;   Drug: Placebo
8 Recruiting The Role of Endothelin in the Supine Hypertension of Autonomic Failure
Conditions: Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions: Drug: BQ123;   Drug: Bq123;   Drug: Saline
9 Recruiting Contribution of Angiotensin II to Supine Hypertension in Autonomic Failure
Conditions: Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy
Interventions: Drug: Losartan;   Drug: Captopril;   Drug: Placebo
10 Recruiting Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes
Conditions: Parkinson's Disease;   Multiple System Atrophy;   Progressive Supranuclear Palsy;   Vascular Parkinsonism
Intervention: Other: MRI exam of the brain
11 Recruiting Reduction in Splanchnic Capacitance Contributes to Sympathetically Dependent Hypertension in Autonomic
Conditions: Multiple System Atrophy;   Orthostatic Hypotension;   Supine Hypertension
Interventions: Drug: Trimethaphan;   Drug: Placebo
12 Recruiting Natural History Study of Synucleinopathies
Condition: Patients With Synucleinopathies
Intervention:
13 Recruiting Treatment of Supine Hypertension in Autonomic Failure
Condition: Hypertension
Interventions: Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
14 Recruiting Evaluation of Primary Chronic Autonomic Failure
Condition: Autonomic Nervous System Diseases
Intervention:
15 Recruiting Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
Condition: Symptomatic Neurogenic Orthostatic Hypotension
Interventions: Drug: Droxidopa capsules;   Drug: Placebo capsules
16 Recruiting Study for the Early Diagnosis of Parkinson's Disease
Condition: Parkinson's Disease, Idiopathic
Intervention:
17 Recruiting Gait Analysis in Neurological Disease
Conditions: Parkinson's Disease;   Parkinsonian Disorders;   Atypical Parkinson Disease;   Progressive Supranuclear Palsy;   Multiple System Atrophy;   Corticobasal Degeneration;   Gait, Frontal
Interventions: Drug: Anti-Parkinson medication;   Device: Deep Brain Stimulation
18 Recruiting Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure
Conditions: Orthostatic Hypotension;   Pure Autonomic Failure;   Multiple System Atrophy;   Autonomic Failure
Interventions: Other: Abdominal compression;   Other: Sham abdominal compression;   Drug: Placebo pill;   Drug: midodrine
19 Recruiting Local Heat Stress in Autonomic Failure Patients With Supine Hypertension
Conditions: Hypertension;   Pure Autonomic Failure;   Multiple System Atrophy;   Autonomic Failure
Interventions: Other: Passive heat stress;   Other: Control (non-heating)
20 Recruiting Post-prandial Hypotension and Sleepiness in Parkinson's Disease and Other Synucleinopathies
Condition: Parkinsonian Disorders
Interventions: Other: V1: HGPO + meal and V2: placebo + meal;   Other: V1: placebo 75mg + meal and V2: HGPO 75mg + meal

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Study has passed its completion date and status has not been verified in more than two years.