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10 studies found for:    "gene therapy" OR "gene transfer" OR "virus delivery" | Blindness
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Rank Status Study
1 Active, not recruiting Gene Therapy for Blindness Caused by Choroideremia
Condition: Choroideremia
Intervention: Drug: rAAV2.REP1
2 Recruiting Clinical Trial of Gene Therapy for the Treatment of Leber Congenital Amaurosis (LCA)
Condition: Leber Congenital Amaurosis
Intervention: Genetic: AAV2/5 OPTIRPE65
3 Active, not recruiting Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis
Conditions: Inherited Retinal Dystrophy Due to RPE65 Mutations;   Leber Congenital Amaurosis
Intervention: Biological: AAV2-hRPE65v2
4 Active, not recruiting Safety Study in Subjects With Leber Congenital Amaurosis
Condition: Leber Congenital Amaurosis
Intervention: Biological: AAV2-hRPE65v2
5 Completed Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65
Condition: Leber Congenital Amaurosis
Intervention: Drug: rAAV2/4.hRPE65
6 Unknown  Clinical Trial of Gene Therapy for Leber Congenital Amaurosis Caused by RPE65 Mutations
Condition: Leber Congenital Amaurosis
Intervention: Genetic: rAAV2-hRPE65
7 Completed Genetic Study of Patients Suffering From Congenital Amaurosis of Leber or From an Early Severe Retinal Dystrophy
Conditions: Amaurosis;   Retinal Diseases
Interventions: Procedure: realization of a family tree;   Procedure: refractometry;   Procedure: evaluation of the presence of a nystagmus;   Procedure: ocular behavior;   Procedure: test of baby vision;   Procedure: test of keenness;   Procedure: reading test;   Procedure: visual field;   Procedure: color vision;   Procedure: electroretinographical activity;   Procedure: biomicroscopical test;   Procedure: retinal imaging;   Procedure: retinal autofluorescence;   Procedure: genotyping
8 Active, not recruiting Phase I Trial of Gene Vector to Patients With Retinal Disease Due to RPE65 Mutations
Conditions: Amaurosis of Leber;   Retinal Diseases
Intervention: Genetic: rAAV2-CBSB-hRPE65
9 Recruiting Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)
Conditions: Leber Congenital Amaurosis (LCA);   Eye Diseases;   Eye Diseases, Hereditary;   Retinal Diseases
Intervention: Genetic: AAV2/5-OPTIRPE65
10 Active, not recruiting
Has Results
Phase 1/2 Safety and Efficacy Study of AAV-RPE65 Vector to Treat Leber Congenital Amaurosis
Condition: Leber Congenital Amaurosis
Intervention: Biological: rAAV2-CB-hRPE65

Study has passed its completion date and status has not been verified in more than two years.