| 1 |
NCT03352167 |
Recruiting |
Antibiotic Resistance in Danish EDs. |
- Antibiotic Resistance, Bacterial
|
|
Observational |
|
- University of Southern Denmark
- Netherlands: Ministry of Health, Welfare and Sports
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Bacterial Antibiotic Resistance
|
10400 |
All |
18 Years and older (Adult, Senior) |
NCT03352167 |
SHS-ED-11-2017 |
AB-RED |
January 8, 2018 |
May 1, 2018 |
June 1, 2018 |
November 24, 2017 |
February 20, 2018 |
|
- Hospital of Southern Jutland
Aabenraa, Denmark - Aalborg University Hospital
Aalborg, Denmark - Aarhus Univerisity Hospital
Aarhus, Denmark - (and 5 more...)
|
| 2 |
NCT03083197 |
Recruiting |
Scrub Typhus Antibiotic Resistance Trial |
|
- Drug: Doxycycline 7 days
- Drug: Doxycycline 3 days
- Drug: Azithromycin 3 days
|
Interventional |
Phase 4 |
- University of Oxford
- Shoklo Malaria Research Unit
- Chiangrai Prachanukroh Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Fever clearance time (FCT)
- Resolution of bacteraemia in relation to Drug plasma level
- Occurrence of severe disease or treatment failure/relapse
- (and 3 more...)
|
177 |
All |
15 Years and older (Child, Adult, Senior) |
NCT03083197 |
START |
START |
October 15, 2017 |
October 2019 |
October 2019 |
March 17, 2017 |
December 14, 2017 |
|
- Shoklo-Malaria Research Unit (SMRU)
Mae Sot, Tak, Thailand - Chiangrai Prachanukroh Hospital
Chiang Rai, Thailand
|
| 3 |
NCT03456739 |
Not yet recruiting |
The Microbiome Variability and Antibiotic Resistance of Chronic Suppurative Otitis |
|
|
Observational |
|
|
Other |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
|
240 |
All |
1 Year to 9 Years (Child) |
NCT03456739 |
0019-18-ZIV |
|
April 20, 2018 |
April 20, 2019 |
February 20, 2020 |
March 7, 2018 |
March 7, 2018 |
|
|
| 4 |
NCT01904188 |
Recruiting |
Clinical Microbial Species and Antibiotic Resistance Identification in Patients Presenting to the Emergency Department With Three of Four Systemic Inflammatory Response Syndrome (SIRS) Criteria - is Rapid Identification Possible and Accurate? |
- Sepsis
- Systemic Inflammatory Response Syndrome
|
|
Observational |
|
- Michigan State University
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Correlation of microbial identification with culture results from clinical laboratory
- Microbial Resistance Gene Pattern
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT01904188 |
C13-033F |
|
June 2015 |
July 2018 |
July 2018 |
July 22, 2013 |
August 30, 2017 |
|
- Sparrow Health System
Lansing, Michigan, United States
|
| 5 |
NCT02909946 |
Recruiting |
Pathway From Functional Disability to Antimicrobial Resistance in Nursing Home Residents |
- Multi-antibiotic Resistance
|
- Behavioral: Multi-modal Infection Control Program
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Prevalence density of multidrug-resistant organisms (MDRO)
- Incidence of multidrug-resistant organisms (MDRO)
- Incidence of healthcare-associated infections
|
478 |
All |
18 Years and older (Adult, Senior) |
NCT02909946 |
R01AG041780 |
|
September 2016 |
August 2018 |
August 2018 |
September 21, 2016 |
September 6, 2017 |
|
- University of Michigan and partner nursing homes
Ann Arbor, Michigan, United States
|
| 6 |
NCT02906774 |
Not yet recruiting |
Fecal Transplant for MDR Pathogen Decolonization |
- Multi-antibiotic Resistance
|
- Biological: Fecal microbiota transplantation (FMT)
|
Observational |
|
- University of British Columbia
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The primary outcome of the study will be the proportion of successfully decolonized patients out of all study patients evaluated, defined as the sustained elimination of a MDR target organism over a minimum of ≥ 2 study visits.
- Determine the number of patients with treatment-related adverse events, as defined by the study adverse event questionnaire (including the Common Terminology Criteria for Adverse Events (v4.0)).
- Estimate the proportion of patients who become re-colonized following FMT.
|
36 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02906774 |
H15-01944 |
|
September 2016 |
December 2017 |
December 2017 |
September 20, 2016 |
September 23, 2016 |
|
- University of British Columbia
Vancouver, British Columbia, Canada
|
| 7 |
NCT03156855 |
Recruiting |
Sequential Therapy Versus Quadruple Therapy in H. Pylori Eradication |
|
- Drug: 14-day sequential therapy
- Drug: Bismuth quadruple therapy
|
Interventional |
Phase 4 |
- National Taiwan University Hospital
- E-DA Hospital
- National Taiwan University Hospital Hsin-Chu Branch
- (and 4 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Eradication rate: determined by urea breath test (13C-UBT, according to ITT analysis)
- adverse effect: occurrence of any adverse effect during the treatment
- changes of antibiotic resistance
|
620 |
All |
20 Years and older (Adult, Senior) |
NCT03156855 |
201506129MINC |
|
September 2015 |
December 2018 |
December 2019 |
May 17, 2017 |
May 17, 2017 |
|
- Chiayi Christian Hospital
Chiayi City, Taiwan - National Taiwan University Hospital, Hsinchu Branch
Hsinchu, Taiwan - E-DA University Hospital
Kaohsiung, Taiwan - (and 4 more...)
|
| 8 |
NCT01725906 |
Recruiting |
Genotypic Resistance Guided Therapy in Helicobacter Pylori Eradication |
|
- Drug: empirical therapy
- Drug: Genotypic resistance guided therapy
|
Interventional |
Phase 4 |
- National Taiwan University Hospital
- National Science Council, Taiwan
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Eradication rate after third line rescue therapy
- eradication rates in subgroup analysis by antibiotic resistance and regimen
|
450 |
All |
20 Years to 85 Years (Adult, Senior) |
NCT01725906 |
201202068MIC |
|
November 2012 |
May 2017 |
December 2017 |
November 14, 2012 |
May 8, 2017 |
|
- National Taiwan Universtiy Hospital
Taipei, Taiwan - National Taiwan University Hospital, Yun-Lin Branch
Yun-Lin County, Taiwan
|
| 9 |
NCT03413020 |
Recruiting |
Tailored Therapy for Helicobacter Pylori Rescue Treatment |
- Helicobacter Pylori Infection
|
- Drug: esomeprazole
- Drug: bismuth Potassium Citrate
- Drug: amoxicillin
- (and 3 more...)
|
Interventional |
Phase 4 |
- Shanghai Jiao Tong University School of Medicine
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Helicobacter pylori eradication rate
- Rate of adverse effects
- Compliance rate
|
200 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03413020 |
rjkls2017198 |
|
January 3, 2018 |
May 31, 2018 |
June 30, 2018 |
January 29, 2018 |
January 29, 2018 |
|
- Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai, China
|
| 10 |
NCT02741414 |
Recruiting |
A Multi-center Study for Eradication of Refractory Helicobacter Pylori |
|
- Device: The result of H pylori culture based on gram staining and enzyme activity testing
- Device: The result of 13C-urea breath test after treatment based on the selection of clarithromycin, levofloxacin, metronidazole, amoxicillin，tetracycline，furazolidone and the dose of esomeprazole
- Device: The result of Amoxicillin resistance in vitro based on antibiotic susceptibility testing
|
Interventional |
Not Applicable |
- Taizhou Hospital
- Centers for Disease Control and Prevention, China
- Academy Military Medical Science, China
- (and 13 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The eradication rate of H. pylori reach to 95% in all groups
- The microflora structure of a total of 240 patients in the first successful eradication group and the refractory infection of H. pylori group
- The proportion of mix infection of H pylori in a total of 240 patients in two groups
- The number of single nucleotide varation（SNV）of 20 patients in the first successful eradication group and the refractory infection of H. pylori group that are related to Amoxicillin resistance
|
4428 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02741414 |
TaizhouH |
|
June 2016 |
April 2018 |
December 2018 |
April 18, 2016 |
July 12, 2016 |
|
- Xianju People Hospital
Taizhou, Zhejiang, China
|
| 11 |
NCT03397433 |
Recruiting |
ANti-infective Stewardship Using the Wisca Tool in the Electronic Medical Record |
|
- Other: Information Technology physician assist
|
Interventional |
Not Applicable |
- NorthShore University HealthSystem Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in length of stay
- Rapid response to initial therapy
- Reduced cost of ancillary testing
- (and 7 more...)
|
6000 |
All |
18 Years and older (Adult, Senior) |
NCT03397433 |
EH13-368 |
ANSWER |
June 2015 |
July 2018 |
October 2018 |
January 12, 2018 |
January 12, 2018 |
|
- NorthShore University HealthSystem Research Institute
Evanston, Illinois, United States
|
| 12 |
NCT02359331 |
Recruiting |
The Efficacy of the 7 Days Tailored Therapy as 2nd Rescue Therapy for Eradication of H. Pylori Infection |
|
- Procedure: H. pylori culture and antimicrobial susceptibility testing
- Drug: 14 days empirical bismuth quadruple therapy (Proton pump inhibitor)
- Drug: Metronidazole
- (and 5 more...)
|
Interventional |
Not Applicable |
- Seoul National University Bundang Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Compare the percentage of participants with successful H. pylori eradication in each groups
|
370 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02359331 |
B1408/285-005 |
|
August 2014 |
November 2020 |
December 2020 |
February 10, 2015 |
April 18, 2018 |
|
- Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of
|
| 13 |
NCT02732249 |
Recruiting |
Clarithromycin Triple Therapy Plus Bismuth for Helicobacter Pylori First-line Treatment |
- Helicobacter Pylori Infection
|
- Drug: Esomeprazole
- Drug: Bismuth Potassium Citrate
- Drug: Clarithromycin
- Drug: Metronidazole
|
Interventional |
Phase 4 |
- Shanghai Jiao Tong University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Helicobacter pylori eradication rate
- Rate of adverse effects
- Compliance rate
|
393 |
All |
18 Years and older (Adult, Senior) |
NCT02732249 |
rjkls2016068 |
|
April 2016 |
July 2017 |
October 2017 |
April 8, 2016 |
March 1, 2017 |
|
- Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai, China
|
| 14 |
NCT03361267 |
Recruiting |
Comparison of Bismuth Containing Quadruple Therapy and Based Tailored Therapy for H. Pylori Infection |
- Helicobacter Pylori Infection
- Compliance, Patient
- Drug Resistance
- Antibiotics
|
- Diagnostic Test: Helicobacter pylori PCR test
- Diagnostic Test: CLO test
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Helicobacter pylori eradication rate
- Rate of adverse effects
- Compliance rate
- Medical cost
|
300 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03361267 |
Inha helicobacter study |
|
December 30, 2017 |
June 28, 2018 |
June 28, 2018 |
December 4, 2017 |
December 12, 2017 |
|
- Inha University Hospital
Incheon, Korea, Republic of
|
| 15 |
NCT03174236 |
Not yet recruiting |
First Line Antimicrobials in Children With Complicated Severe Acute Malnutrition |
- Malnutrition Severe
- Antibiotic Resistance
- Antibiotic Toxicity
|
- Drug: Ceftriaxone
- Drug: Benzyl penicillin plus gentamicin
- Drug: Metronidazole
- Other: Placebo
|
Interventional |
Phase 3 |
- University of Oxford
- University College London, UK.
- London School of Hygiene & Tropical Medicine, UK.
- (and 6 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mortality
- Grade 4 toxicity
- Serious adverse events
- (and 10 more...)
|
2000 |
All |
2 Months to 13 Years (Child) |
NCT03174236 |
KEMRI/SERU/CGMR-C/063/3399
1-17
105431/Z/14/Z |
FLACSAM |
June 5, 2017 |
April 30, 2020 |
December 31, 2021 |
June 2, 2017 |
June 2, 2017 |
|
- Kilifi County Hospital
Kilifi, Coast, Kenya - Coast General Hospital - Study site
Mombasa, Kenya - Mbagathi Hospital
Nairobi, Kenya - Mbale Regional Referral Hospital
Mbale, Uganda
|
| 16 |
NCT03284749 |
Recruiting |
Effect of Copper on the Healing of Obstetric Wounds |
- Cesarean Section; Infection
- Perineal Infection
- Wound Infection
- Surgical Site Infection
|
- Other: Copper impregnated wound dressing
- Other: Normal wound dressing
- Other: Copper impregnated maternity pads
- Other: Normal maternity pads
|
Interventional |
Not Applicable |
- Croydon Health Services NHS Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Post Discharge Questionnaire (PDQ)
- Length of hospitalisation
- Pain score
|
750 |
Female |
18 Years and older (Adult, Senior) |
NCT03284749 |
15/07 |
ECHO |
January 14, 2016 |
December 1, 2017 |
December 31, 2017 |
September 15, 2017 |
September 15, 2017 |
|
- Croydon Health Services NHS Trust
Croydon, United Kingdom
|
| 17 |
NCT03148366 |
Recruiting |
Comparison of the Levofloxacin Sequential Therapy and Quadruple Therapy in Second Line Treatment for HP |
|
- Drug: Levofloxacin based sequential therapy
- Drug: bismuth quadruple therapy for 10 days (BQ)
|
Interventional |
Phase 3 |
- National Taiwan University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Eradication rate after second line eradication therapy according to ITT analysis
- Adverse effects during eradication therapy
- Long term eradication rate 1 year after eradication therapy
- changes of gut microbiota before and after eradication therapy
|
560 |
All |
20 Years and older (Adult, Senior) |
NCT03148366 |
201410001MINC |
|
February 2015 |
December 2018 |
April 2019 |
May 11, 2017 |
May 11, 2017 |
|
- National Taiwan University Hospital
Taipei, Taiwan - National Taiwan University Hospital, Yunlin branch
Yunlin, Taiwan
|
| 18 |
NCT03388424 |
Recruiting |
Quantification of Microbiota in Health and Diseases |
|
- Diagnostic Test: quantification of microbiota
|
Observational |
|
- University of Cantanzaro
- Azienda Sanitaria Provinciale Di Catanzaro
|
Other |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
- Determination of microbiota percentage
- Determination of antibiotic resistance gene
|
120 |
All |
4 Years to 90 Years (Child, Adult, Senior) |
NCT03388424 |
Microbiota2018 |
qMHD |
November 22, 2017 |
May 21, 2018 |
November 21, 2018 |
January 3, 2018 |
January 4, 2018 |
|
- AO Materdomini
Catanzaro, Italia, Italy
|
| 19 |
NCT02414399 |
Recruiting |
Azithromycin to Prevent Post-discharge Morbidity and Mortality in Kenyan Children |
- Pneumonia
- Diarrhea
- Malaria
- (and 3 more...)
|
- Drug: Azithromycin
- Drug: Placebo
|
Interventional |
Phase 4 |
- University of Washington
- Kenya Medical Research Institute
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Composite outcome of mortality and hospital readmission
- Mean change in length for age z-score (LAZ) between baseline and outcome assessment
- The number of children with diarrhea re-hospitalizations following randomization
- (and 8 more...)
|
1400 |
All |
1 Month to 59 Months (Child) |
NCT02414399 |
STUDY00002592
R01HD079695 |
Toto Bora |
June 2016 |
December 2019 |
December 2020 |
April 10, 2015 |
July 19, 2017 |
|
- Kisii Teaching and Referral Hospital & Homa Bay District Hospital
Kisii and Homa Bay Counties, Kenya
|
| 20 |
NCT03087890 |
Recruiting |
Impact of Cotrimoxazole Use in Immunocompetent HIV Patients on Carriage of Antimicrobial Resistant Bacteria |
- HIV-1-infection
- Pneumocystis Pneumonia
- Opportunistic Infections
- (and 2 more...)
|
- Drug: Cotrimoxazole
- Drug: Placebo
|
Interventional |
Phase 4 |
- University of Bergen
- Haukeland University Hospital
- Muhimbili University of Health and Allied Sciences
- Helse Vest
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in carriage of resistant bacteria in gut and/or nose by week 2
- Change in carriage of resistant bacteria in gut and/or nose by week 24
- Change in carriage of resistant bacteria in gut and/or nose by week 48
- (and 3 more...)
|
500 |
All |
18 Years and older (Adult, Senior) |
NCT03087890 |
REK2015/540
TZ16CT007
NIMRlHQ/R.SaJVol. 1X12144
2015-10-27/AEC/Vol.X/54 |
CoTrimResist |
March 30, 2017 |
October 30, 2018 |
October 30, 2018 |
March 23, 2017 |
April 5, 2018 |
|
- Amana Regional Referral Hospital
Dar es Salaam, Tanzania - Mbagala District Hospital
Dar es Salaam, Tanzania - Mnazimmoja Health Centre
Dar Es Salaam, Tanzania - (and 3 more...)
|
| 21 |
NCT03140085 |
Recruiting |
Bacteriophages for Treating Urinary Tract Infections in Patients Undergoing Transurethral Resection of the Prostate |
- Intravesical Bacteriophage Treatment for Urinary Tract Infections
|
- Biological: PYO Phage
- Drug: Antibiotics
- Other: Sterile bacteriology media
|
Interventional |
Phase 2
Phase 3 |
- Balgrist University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Normalisation of urine culture
- Urine culture
- Bladder diary
- (and 2 more...)
|
81 |
All |
18 Years and older (Adult, Senior) |
NCT03140085 |
02/283 |
|
November 1, 2015 |
December 31, 2017 |
December 31, 2017 |
May 4, 2017 |
May 8, 2017 |
|
- National Center of Urology
Tbilisi, Georgia
|
| 22 |
NCT01892488 |
Recruiting |
Study to Demonstrate That Antibiotics Are Not Needed in Moderate Acute Exacerbations of COPD |
- Chronic Obstructive Pulmonary Disease (COPD)
|
- Drug: Sultamicillin
- Drug: Placebo
|
Interventional |
Phase 4 |
- Hannover Medical School
- CAPNETZ Stiftung
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Additional antibiotic therapy to study medication during treatment period or until the test of cure visit (at day 30)
- To evaluate long-term consequences of Placebo treatment
- To assess patient's clinical improvement relative to treatment
- To assess additional efficacy endpoints and health outcome evaluations
|
980 |
All |
40 Years and older (Adult, Senior) |
NCT01892488 |
Protocol-Code: 002/2012
2012-003234-16 |
|
June 2013 |
April 2018 |
September 2018 |
July 4, 2013 |
February 23, 2017 |
|
- Universitätsklinikum Aachen
Aachen, Germany - HELIOS Klinikum Emil von Behring Berlin
Berlin, Germany - Universitätsklinikum Dresden
Dresden, Germany - (and 8 more...)
|
| 23 |
NCT03350178 |
Recruiting |
Evaluation of Heterologous Fecal microbiotA Transfer in ICU Patients: a FeasibilitY and SafetY StudY |
- Intensive Care Units
- Fecal Microbiota Transplantation
|
- Drug: fecal microbiota transfer
|
Interventional |
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Occurrence of FMT-related treatment emergent (serious) adverse events
- Number of participants with treatment-related adverse events as assessed by CTCAE v4.0
- Occurrence of FMT-related treatment emergent (serious) adverse events as per investigator's opinion
- Evaluation of FMT impact on Multi Drug Resistant Bacteria carriage
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT03350178 |
MPICU01 |
HAPY3 |
January 15, 2018 |
May 15, 2018 |
May 15, 2018 |
November 22, 2017 |
February 28, 2018 |
|
- Salengro hospital
Lille, France - Bichat Hospital
Paris, France
|
| 24 |
NCT03265028 |
Not yet recruiting |
TRACE E-learning Implementation in Belgium |
- Respiratory Tract Infections
|
- Behavioral: TRACE e-learning
|
Interventional |
Not Applicable |
- Universiteit Antwerpen
- Belgian Antibiotic Policy Coordination Committee (BAPCOC)
|
Other |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Antibiotic use (short term)
- Antibiotic use (intermediate term)
- Antibiotic use (long term)
|
15000 |
All |
Child, Adult, Senior |
NCT03265028 |
TRACE Implementation |
|
September 2017 |
January 2019 |
December 2019 |
August 29, 2017 |
September 20, 2017 |
|
|
| 25 |
NCT03226314 |
Recruiting |
Community Epidemiology and Typology of Third-generation Cephalosporins Resistant Enterobacteriaceae in Reunion Island |
|
|
Observational |
|
- Centre Hospitalier Universitaire de la Réunion
|
Other |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
- Digestive prevalence rate of 3GCREB
|
650 |
All |
18 Years and older (Adult, Senior) |
NCT03226314 |
2015/CHU/14 |
AB-RUN |
November 21, 2017 |
May 2018 |
September 2018 |
July 21, 2017 |
December 19, 2017 |
|
- Chu Reunion Island
Saint-Pierre, Reunion Island, Réunion
|
| 26 |
NCT02443285 |
Recruiting |
Is Spontaneous Bacterial Peritonitis Still Responding to 3rd Generation Cephalosporins? |
- Primary Bacterial Peritonitis
|
- Drug: Cefotaxime
- Drug: ceftriaxone
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- number of patients with clearence of infection
|
100 |
All |
Child, Adult, Senior |
NCT02443285 |
SBP TREATMENT |
|
January 2015 |
December 2019 |
December 2019 |
May 13, 2015 |
June 20, 2017 |
|
- Tanta university - faculty of medicine
Cairo, Egypt
|
| 27 |
NCT03391674 |
Not yet recruiting |
Fecal Microbiota Transplantation for Eradication of Carbapenem-resistant Enterobacteriaceae Colonization |
- Antibiotic Resistant Strain
- Microbial Colonization
|
- Other: Fecal Microbiota Transplantation
|
Interventional |
Not Applicable |
- Rambam Health Care Campus
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- CRE Decolonization defined as 3 consecutive negative rectal samples for CRE
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT03391674 |
0595-17-RMB |
|
March 1, 2018 |
February 28, 2019 |
October 30, 2019 |
January 5, 2018 |
January 9, 2018 |
|
|
| 28 |
NCT03167398 |
Not yet recruiting |
Fecal Microbiota Transplantation for Eradication of CRE |
- Antibiotic Resistant Strain
- Microbial Colonization
|
- Other: Fecal Microbiota Transplantation
|
Interventional |
Not Applicable |
- Rambam Health Care Campus
- Tel-Aviv Sourasky Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- CRE eradication on rectal stool samples
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT03167398 |
0215-17-RMB-CTIL |
|
November 1, 2017 |
August 30, 2018 |
October 30, 2018 |
May 30, 2017 |
September 29, 2017 |
|
|
| 29 |
NCT03266003 |
Recruiting |
An Evaluation of Traditional Directly Observed Therapy (DOT) and Electronic DOT for TB Treatment |
- Tuberculosis
- Drug-resistant Tuberculosis
- Adherence, Medication
- Adherence, Patient
|
- Other: Electronic DOT
- Other: In-person DOT
|
Interventional |
Not Applicable |
- Centers for Disease Control and Prevention
- New York City Department of Health and Mental Hygiene
- Columbia University
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Proportion of medication doses directly observed
- Proportion of medication doses not directly observed
- Medication side effects
|
304 |
All |
12 Years and older (Child, Adult, Senior) |
NCT03266003 |
CDC-6995.0 |
|
July 19, 2017 |
July 2019 |
December 2019 |
August 29, 2017 |
August 29, 2017 |
|
- Fort Greene Chest Center
Brooklyn, New York, United States - Corona Chest Center
Jackson Heights, New York, United States - Washington Heights Chest Center
New York, New York, United States - Morrisania Chest Center
The Bronx, New York, United States
|
| 30 |
NCT03120975 |
Not yet recruiting |
Computerized Antibiotic Stewardship Study |
|
- Other: Computerized decision support and audit & feedback
- Other: Audit & Feedback
- Other: Standard antibiotic stewardship
|
Interventional |
Not Applicable |
- Benedikt Huttner
- Swiss National Science Foundation
- University of Geneva, Switzerland
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Days of therapy (DOT)/admission
- Days of therapy/1000 patient days
- Defined daily doses (DDD)/1000 patient days (PD) and per admission
- (and 16 more...)
|
5000 |
All |
16 Years and older (Child, Adult, Senior) |
NCT03120975 |
2017-00454
407240_167079 |
COMPASS |
April 1, 2018 |
March 31, 2019 |
March 31, 2020 |
April 19, 2017 |
April 21, 2017 |
|
- Geneva University Hospitals
Geneva, GE, Switzerland - Ente Ospedaliera Cantonale - Ospedale San Giovanni
Bellinzona, TI, Switzerland - Ente Ospedaliera Cantonale - Ospedale Civico
Lugano, TI, Switzerland
|
| 31 |
NCT03333408 |
Not yet recruiting |
Determining the Necessity for Postoperative Antibiotics After Salivary Stent Placement |
|
- Drug: Postoperative Oral Antibiotics (Clindamycin or Augmentin)
|
Interventional |
Phase 4 |
- Our Lady of the Lake Hospital
- Louisiana State University Health Sciences Center in New Orleans
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03333408 |
LSUHSC-IRB 9908 |
|
November 2017 |
September 2018 |
November 2018 |
November 6, 2017 |
November 6, 2017 |
|
- Our Lady of the Lake Regional Medical Center
Baton Rouge, Louisiana, United States
|
| 32 |
NCT02621359 |
Recruiting |
A Two Week Nitazoxanidebased Quadruple Regimen |
|
- Drug: Nitazoxanide
- Drug: Levofloxacin
- Drug: Doxycyclin
- Drug: Omeprazole
|
Interventional |
Phase 3 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of patients with eradicated helicobacter
|
100 |
All |
Child, Adult, Senior |
NCT02621359 |
Quadruple therapy |
|
January 2015 |
December 2022 |
December 2022 |
December 3, 2015 |
January 3, 2018 |
|
- Tropical medicine dept.-Tanta university hospital
Tanta, Egypt
|
| 33 |
NCT03208764 |
Recruiting |
Inhaled Nitric Oxide for Patients With MABSC |
- Mycobacterium Abscessus Infection
|
|
Interventional |
Phase 2 |
- Advanced Inhalation Therapies Ltd
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Safety measured by NO-related Serious Adverse Events
- Six minute walk test
- Mycobacterium Abscesuss load in sputum
- (and 2 more...)
|
10 |
All |
6 Years and older (Child, Adult, Senior) |
NCT03208764 |
AIT_ CP_ CFNTM_01 |
|
July 24, 2017 |
December 15, 2017 |
April 15, 2018 |
July 6, 2017 |
February 7, 2018 |
|
- Rambam Medical Center
Haifa, Israel
|
| 34 |
NCT02463721 |
Recruiting |
Identification of Ascitic Fluid Bacterial Pathogens in Spontaneous Bacterial Peritonitis |
- Primary Bacterial Peritonitis
|
- Other: ascitic fluid culture and microbiological testing
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- identification of SBP bacterial pathogens through gram stain or other specific stains
|
100 |
All |
Child, Adult, Senior |
NCT02463721 |
SBP |
|
January 2015 |
December 2019 |
December 2019 |
June 4, 2015 |
January 3, 2018 |
|
- Tanta university hospital
Tanta, Egypt
|
| 35 |
NCT03042624 |
Recruiting |
Efficacy of Fermented Rice Flour for the Treatment of Atopic Dermatitis: Randomized, Double-blind Controlled Trial |
- Dermatitis, Atopic
- Child
- Infant
|
- Dietary Supplement: Fermented rice
- Dietary Supplement: Maltodextrins
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
50 |
All |
6 Months to 36 Months (Child) |
NCT03042624 |
FERCT16 |
|
January 24, 2017 |
May 31, 2017 |
May 31, 2017 |
February 3, 2017 |
February 3, 2017 |
|
- Pediatrics Department Ospedale dei Bambini V. Buzzi
Milano, Italy
|
| 36 |
NCT03355885 |
Recruiting |
Early-onset Pneumonia After Out-of-hospital Cardiac Arrest |
- Out-of-Hospital Cardiac Arrest
|
|
Observational |
|
- University Hospital, Brest
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- delay between intensive care admission and antibiotic initiation
- delta respiratory SOFA score between Day 1 and day 3
|
240 |
All |
18 Years and older (Adult, Senior) |
NCT03355885 |
PP-ACR |
PP-ACR |
October 3, 2016 |
May 31, 2018 |
July 2018 |
November 28, 2017 |
November 29, 2017 |
|
- CHRU de Brest
Brest, France
|
| 37 |
NCT03342456 |
Not yet recruiting |
The Efficacy and Safety of Ilaprazole/Doxycycline-based Bismuth-containing Quadruple Therapy on Hp Infected Duodenal Ulcers |
- Duodenal Ulcer Due to Helicobacter Pylori
|
- Drug: Doxycycline Hyclate Enteric-Coated Capsules
- Drug: Amoxicillin Capsules
- Drug: Ilaprazole Enteric-Coated Tablets
- (and 2 more...)
|
Interventional |
Phase 4 |
- The Third Xiangya Hospital of Central South University
- Livzon Pharmaceutical Group Inc.
- Yung Shin Pharm. Ind. Co., Ltd.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The eradication rate of H. pylori infection
- The healing rate of duodenal ulcer(s)
- Number of duodenal ulcer(s)
- (and 4 more...)
|
240 |
All |
18 Years to 65 Years (Adult) |
NCT03342456 |
xucanxia2000 |
|
November 20, 2017 |
May 20, 2018 |
June 20, 2018 |
November 17, 2017 |
November 17, 2017 |
|
- Hunan Provincial People's Hospital
Changsha, Hunan, China - Changsha Central Hospital
Changsha, Hunan, China - The First Hospital of Changsha City
Changsha, Hunan, China - (and 6 more...)
|
| 38 |
NCT01611740 |
Recruiting |
Contribution of Real Time Analyses of CARdio-RESpiratory Signals to the Diagnosis of Infection in PREterM Infants |
|
- Procedure: Analysis of the heart rate and respiratory characteristics / Telemonitoring system prototype developed by INSERM U-642
|
Observational |
|
- Rennes University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Diagnosis of proven or suspected bacterial infection
- Inflammation without proven or suspected bacterial infection defined as follows: a 6 hours period with CRP> 5 mg/L not classified as proven or suspected bacterial infection.
- Periods of discomfort defined as at least two EDIN scores above 3 in a 6 hours period
|
500 |
All |
24 Weeks to 32 Weeks (Child) |
NCT01611740 |
2011-A00324-37 |
CARESS_PREMI |
May 2012 |
November 2017 |
January 2018 |
June 5, 2012 |
August 29, 2017 |
|
- CHU Angers
Angers, Maine et Loire, France - CHU de Lille
Lille, France - CHU de Rennes
Rennes, France
|
| 39 |
NCT03043339 |
Recruiting |
Characterization Of the Intestinal Microbiome Evolution After Kidney Transplant Donation or Receipt |
|
- Other: Stool Specimen Collection
- Other: Anal Swab Sampling
- Other: Short Diet Assessment (SDA)
- Other: NHANES Dietary Screener Questionnaire (DSQ)
|
Observational |
|
- Emory University
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Observational Model: Other
- Time Perspective: Prospective
|
- Change in microbiota composition
- Change in microbiota diversity
- Change in microbiota taxonomy
- (and 4 more...)
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT03043339 |
IRB00092450
16IPA1609418
16IPA1609428 |
COMET-DR |
October 2, 2017 |
December 2018 |
December 2019 |
February 6, 2017 |
November 22, 2017 |
|
- The Emory Clinic
Atlanta, Georgia, United States - Emory University Hospital
Atlanta, Georgia, United States
|
| 40 |
NCT03226158 |
Recruiting |
Next Generation Pathogen Sequencing for Prediction of Adverse Events |
|
|
Observational |
|
- St. Jude Children's Research Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of NGS-positive results
- Proportion of NGS-negative results
|
200 |
All |
up to 24 Years (Child, Adult) |
NCT03226158 |
PREDSEQ |
|
August 9, 2017 |
October 31, 2020 |
October 31, 2020 |
July 21, 2017 |
August 15, 2017 |
|
- St. Jude Children's Research Hospital
Memphis, Tennessee, United States
|
| 41 |
NCT02466438 |
Recruiting |
Safety and Pharmacokinetics of Piperacillin-tazobactam Extended Infusion in Infants and Children (PIP-TAZO) |
|
- Drug: Piperacillin-tazobactam
|
Interventional |
Phase 1 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Evaluation of Clearance (CL) for piperacillin and tazobactam
- Proportion of subjects who achieve Pharmacodynamic target (at least 50% of free plasma piperacillin concentration above the MIC [50% fT > MIC])
- Evaluation of Volume of distribution (V) for piperacillin and tazobactam
- Proportion of subjects experiencing adverse events (AEs)
|
141 |
All |
2 Months to 6 Years (Child) |
NCT02466438 |
CHUSJ-4131 |
PIP-TAZO |
January 2016 |
December 2018 |
December 2018 |
June 9, 2015 |
April 19, 2018 |
|
- St. Justine's Hospital
Montreal, Quebec, Canada
|
| 42 |
NCT02328131 |
Recruiting |
European Registry on the Management of Helicobacter Pylori Infection |
|
|
Observational |
|
- Javier P. Gisbert
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Prescribed treatment for H. pylori
- Adverse Events
- Efficacy
- Anonymised patient identifiers
|
10000 |
All |
18 Years and older (Adult, Senior) |
NCT02328131 |
Hp-EuReg |
|
June 2013 |
December 2024 |
December 2024 |
December 31, 2014 |
February 11, 2016 |
|
- Medical University Wien
Wien, Austria - CHU de Charleroi, Charleroi
Charleroi, Belgium - Medical University of Sofia
Sofia, Bulgaria - (and 27 more...)
|
| 43 |
NCT02848482 |
Not yet recruiting |
Anti-infective Effect of Non-surgical Treatment With and Without Photodynamic Therapy on Initial Peri-implantitis |
|
- Device: Photodynamic therapy
- Procedure: Mechanical debridement
- Drug: Irrigation
|
Interventional |
Phase 3 |
- Shanghai 9th People's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change of percentage of bleeding on probing sites
- Change of Probing Pocket Depth
- Change of modified plaque index
- (and 3 more...)
|
54 |
All |
18 Years and older (Adult, Senior) |
NCT02848482 |
1036_2016 |
|
May 2017 |
May 2018 |
|
July 28, 2016 |
July 28, 2016 |
|
- Shanghai Ninth People's Hospital
Shanghai, China
|
| 44 |
NCT03275870 |
Recruiting |
Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa |
- Hidradenitis Suppurativa
- Hidradenitis
- Acne Inversa
- (and 3 more...)
|
|
Interventional |
Phase 1
Phase 2 |
- Elena Gonzalez Brant
- University of Pittsburgh
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement in disease severity
- Improvement in quality of life
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03275870 |
PRO17030612 |
|
September 28, 2017 |
June 2019 |
June 2019 |
September 8, 2017 |
November 7, 2017 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
| 45 |
NCT03180983 |
Not yet recruiting |
Antibiotic Use in French Nursing Home |
- Antibiotic Resistant Infection
|
- Behavioral: multimodal intervention
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Antibiotics prescription for UTI
- Total prescriptions of antibiotics
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03180983 |
Prot_ATOUM4_V1 |
|
January 1, 2018 |
December 31, 2018 |
February 28, 2019 |
June 8, 2017 |
July 26, 2017 |
|
|
| 46 |
NCT02422706 |
Recruiting |
Study of Nitazoxanide (NTZ) Based New Therapeutic Regimens for Helicobacter Pylori |
- Helicobacter-associated Gastritis
|
- Drug: Nitazoxanide
- Drug: Metronidazole(MTZ)
- Drug: Omeprazole
- (and 3 more...)
|
Interventional |
Phase 3 |
- Sherief Abd-Elsalam
- Tanta University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Number of patients with proven eradication of helicobacter
|
120 |
All |
Child, Adult, Senior |
NCT02422706 |
HELICOBACTER NEW TREATMENT |
|
January 2015 |
December 2018 |
December 2018 |
April 21, 2015 |
April 25, 2017 |
|
- Tanta university hospital
Cairo, Egypt
|
| 47 |
NCT02619903 |
Not yet recruiting |
The Oral Microbiota as Reservoir for Systemic Opportunistic Pathogens |
- Peptic Ulcer
- Pulmonary Disease, Chronic Obstructive
- Dental Plaque
|
- Procedure: Dental cleaning
|
Interventional |
Not Applicable |
- Malmö University
- Lund University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- COPD exacerbations in 12 months
- Recurrence of peptic ulcer
- COPD symptoms
- Gastric symptoms
|
400 |
All |
18 Years and older (Adult, Senior) |
NCT02619903 |
2015-279 |
|
February 2016 |
December 2017 |
December 2018 |
December 2, 2015 |
December 4, 2015 |
|
|
| 48 |
NCT03299751 |
Recruiting |
Evaluation of bioMarkErs to Reduce Antibiotics Use in hospitalizeD nEonates |
- Late-Onset Neonatal Sepsis
|
- Biological: Diagnostic performances of biomarkers combination
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- LOS diagnosis in NICU newborns of at least 7 days of life with suggestive clinical signs, confirmed by adjudication committee
- LOS diagnosis in NICU preterm neonates, whose weight at birth is less than 1500 grams, of at least 7 days of life, with suggestive clinical signs, confirmed by adjudication committee.
|
200 |
All |
Child, Adult, Senior |
NCT03299751 |
69HCL17_0492 |
EMERAUDE |
November 22, 2017 |
November 2019 |
November 2019 |
October 3, 2017 |
December 8, 2017 |
|
- Hospices Civils de Lyon
Bron, France
|
| 49 |
NCT02547116 |
Not yet recruiting |
Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis |
|
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- change in small colony variant Staph. aureus colony forming units on induced sputum respiratory culture
- change in lung function, as measured by forced expiratory volume in one second (FEV1)
- patient reported symptoms/quality of life, as captured in the Cystic Fibrosis Questionnaire-Revised (CFQ-R)
|
16 |
All |
12 Years and older (Child, Adult, Senior) |
NCT02547116 |
IRB00047491 |
|
November 2015 |
July 2018 |
July 2018 |
September 11, 2015 |
December 7, 2017 |
|
|
| 50 |
NCT03077711 |
Recruiting |
Methenamine Hippurate Versus Trimethoprim in the Prevention of Recurrent UTIs |
- Urinary Tract Infections, Recurrent
|
- Drug: Trimethoprim
- Drug: Methenamine hippurate
|
Interventional |
Phase 4 |
- NorthShore University HealthSystem
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Time to subsequent infection as defined from time of treatment initiation to recurrence of UTI
- Infection free patients
- Number of infections
- (and 4 more...)
|
130 |
Female |
18 Years to 99 Years (Adult, Senior) |
NCT03077711 |
EH16-216 |
|
June 2016 |
June 2018 |
June 2019 |
March 13, 2017 |
April 4, 2017 |
|
- NorthShore Univeristy HealthSystem
Skokie, Illinois, United States
|
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