| 1 |
NCT01662427 |
Completed |
Nocturnal Parkinson's Disease Symptoms Study Group |
|
- Other: Questionaire to assess Noctural Parkinson's Disease Symptoms
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To assess Noctural Parkinson's Disease Symptoms
- To assess quality of life in Parkinson's Disease patient
- To assess quality of life in caregiver of Parkinson's Disease patient
|
300 |
All |
30 Years to 90 Years (Adult, Senior) |
NCT01662427 |
6222012 |
|
November 2012 |
August 2013 |
August 2013 |
August 10, 2012 |
August 20, 2013 |
|
- Roongroj Bhidayasiri
Pathumwan, Bangkok, Thailand
|
| 2 |
NCT02975193 |
Recruiting |
Neural Correlates of Cognition in Parkinson's Disease |
|
- Behavioral: Computer task assessing cognition
- Behavioral: Impulsive-Compulsive Disorders in Parkinson's Disease
- Behavioral: Montreal Cognitive Assessment
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in behavioral performance
- Change in Score on Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease - Rating Scale (QUIP-RS)
- Change in Score on Montreal Cognitive Assessment (MoCA)
- Local field potential brain signal
|
45 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02975193 |
IRB201601780 |
|
February 1, 2017 |
December 2018 |
February 2019 |
November 29, 2016 |
March 9, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
| 3 |
NCT03105401 |
Recruiting |
Phenomenological and Psychopathological Factors Associated to Hallucinations in Parkinson's Disease |
|
- Other: Assessment of hallucinations in Parkinson's disease
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- Hallucinations Prevalence
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT03105401 |
69HCL17_0137 |
HALLUPARK |
May 15, 2017 |
January 15, 2019 |
January 15, 2019 |
April 10, 2017 |
February 19, 2018 |
|
- Hôpital des Charpennes. Centre de Recherche Clinique - vieillissement, cerveau, fragilité
Villeurbanne, France
|
| 4 |
NCT03152721 |
Enrolling by invitation |
The Effect of Parkinson Kinetigraph Recordings on the Management and Outcome in Parkinson's Disease |
|
- Device: Parkinson KinetiGraph
- Other: Self assessment
|
Interventional |
Not Applicable |
- Sahlgrenska University Hospital, Sweden
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Decision to change management
- Actual change of management
- Patient Reported Experience of Care
- (and 17 more...)
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT03152721 |
WestPORTSintervention
PARKreg |
|
April 30, 2017 |
May 30, 2018 |
September 30, 2018 |
May 15, 2017 |
November 30, 2017 |
|
- Sahlgrenska University Hospital
Göteborg, Sweden
|
| 5 |
NCT02370134 |
Unknown † |
Development of Parkinson's Glove for Detection and Suppression of Hand Tremor |
|
- Device: Parkinson's glove
- Device: sham glove
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Number of participants who demonstrate the tremor suppression after use parkinson's glove
- Number of Participants who report pain or any adverse events from parkinson's glove
- Determine the severity of pain related with parkinson's glove
|
50 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02370134 |
005/58 |
|
February 2015 |
January 2016 |
May 2017 |
February 24, 2015 |
February 24, 2015 |
|
- Chulalongkorn University Hospital
Pathumwan, Bangkok, Thailand
|
| 6 |
NCT02016092 |
Unknown † |
Biomarker Discovery in Parkinson's Disease |
|
|
Observational |
|
- The Parkinson's Institute
- The Parkinson's Institute
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Biological markers of Parkinson's disease
- Correlation between biologic markers and clinical features of PD
|
400 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02016092 |
ECH-13-24
5258 |
DISCOVERY-PD |
December 2013 |
March 2016 |
June 2016 |
December 19, 2013 |
March 14, 2016 |
|
- The Parkinson's Institute and Clinical Center
Sunnyvale, California, United States
|
| 7 |
NCT03466723 |
Not yet recruiting |
miRNAs Profiling in Parkinson's Disease |
|
- Genetic: biomarker identification in Parkinson disease
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Identification of novel circulating miRNAs as biomarkers for Parkinson's disease
|
1000 |
All |
30 Years and older (Adult, Senior) |
NCT03466723 |
DRPAR01 |
|
June 2018 |
December 2019 |
May 2021 |
March 15, 2018 |
March 19, 2018 |
|
- Neuromed IRCCS
Pozzilli, Molise, Italy
|
| 8 |
NCT02937688 |
Recruiting |
Deep Brain Stimulation (DBS) for Parkinson's Disease International Study |
|
- Device: Medtronic DBS Therapy for Parkinson's disease
|
Observational |
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in Parkinson's disease-related quality of life, as measured by the Parkinson's Disease Questionnaire (PDQ-8).
- Change in motor score, as measured by the Unified Parkinson's Disease Rating Scale (UPDRS) III, off medication
|
264 |
All |
22 Years and older (Adult, Senior) |
NCT02937688 |
1678 |
REACH-PD |
July 26, 2017 |
April 2021 |
April 2021 |
October 18, 2016 |
March 26, 2018 |
|
- Xuanwu Hospital Capital Medical University
Beijing, China - Huaxi Hospital
Chengdu, China - The First Affiliated Hospital of Sun Yat-Sen University
Guangzhou, China - (and 4 more...)
|
| 9 |
NCT03241966 |
Recruiting |
Perception, Cognition, and Gait in Parkinson's Disease |
|
|
Observational |
|
- Boston University Charles River Campus
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Parkinson's Disease Questionnaire (PDQ-39)
|
1536 |
All |
40 Years to 100 Years (Adult, Senior) |
NCT03241966 |
1204E |
|
April 1, 2017 |
April 1, 2019 |
April 1, 2019 |
August 8, 2017 |
August 8, 2017 |
|
- Vision and Cognition Laboratory at Boston University
Boston, Massachusetts, United States
|
| 10 |
NCT03336307 |
Completed |
Predictors of Gait Improvement in Patients With Parkinson's Disease After Rehabilitation |
- Parkinson Disease
- Movement Disorders
|
- Other: Rehabilitation program
|
Observational |
|
- University of Roma La Sapienza
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- stance duration (change)
- step length (change)
- Step width (change)
- (and 7 more...)
|
36 |
All |
48 Years to 80 Years (Adult, Senior) |
NCT03336307 |
s001 |
|
May 2014 |
April 2017 |
July 2017 |
November 8, 2017 |
November 8, 2017 |
|
- Policlinico Italia Srl
Rome, Lazio, Italy
|
| 11 |
NCT02763683 |
Recruiting |
Dementia in Parkinson Disease |
|
|
Observational |
|
- Washington University School of Medicine
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Investigations of Dementia in Parkinsons Disease
|
320 |
All |
50 Years and older (Adult, Senior) |
NCT02763683 |
201512032 |
PIB |
June 2016 |
March 2030 |
March 2030 |
May 5, 2016 |
November 6, 2017 |
|
- Washington University in St. Louis
Saint Louis, Missouri, United States
|
| 12 |
NCT02701621 |
Completed |
Aquatic Therapy Versus Land-Based Therapy for the Treatment of Balance Dysfunction in Parkinson's Disease |
|
- Other: MIRT-AT
- Other: MIRT
|
Interventional |
Not Applicable |
- Ospedale Generale Di Zona Moriggia-Pelascini
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Berg Balance Scale
- TUG
- Unified Parkinson's Disease Rating Scale II
- Unified Parkinson's Disease Rating Scale III
|
34 |
All |
60 Years to 80 Years (Adult, Senior) |
NCT02701621 |
ATvsLB Therapy for BD in PD |
|
September 2014 |
December 2014 |
December 2014 |
March 8, 2016 |
March 8, 2016 |
|
- Department of Parkinson's Disease and Brain Injury Rehabilitation, of the 'Moriggia-Pelascini' Hospital
Gravedona ed Uniti, Como, Italy
|
| 13 |
NCT01532986 |
Completed |
Randomized Trial to Test the "Coordinated Care for Health Promotion and Activities in Parkinson's Disease" Intervention in the Veterans Administration |
|
- Other: Coordinated care management for Parkinson's disease
- Other: Educational handout
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Change from Baseline in Adherence to the guidelines for Parkinson's disease care at 18 months
- Health Utilities Index (HUI)
- General Self-Efficacy Scale (GSES)
- (and 21 more...)
|
345 |
All |
18 Years and older (Adult, Senior) |
NCT01532986 |
NRI 11-126 |
CHAPS |
July 9, 2012 |
January 31, 2017 |
April 30, 2017 |
February 15, 2012 |
August 4, 2017 |
|
- VA Loma Linda Healthcare System, Loma Linda, CA
Loma Linda, California, United States - VA Long Beach Healthcare System, Long Beach, CA
Long Beach, California, United States - VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States - (and 2 more...)
|
| 14 |
NCT02283073 |
Active, not recruiting |
Study for the Early Diagnosis of Parkinson's Disease |
- Parkinson's Disease, Idiopathic
|
|
Observational |
|
|
Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- The Diagnostic Accuracy of PDx mRNA Assay in Diagnosing Idiopathic Parkinson's Disease
- Diagnostic Accuracy of each one of the PDx assay's expressed genes for Differentiating Idiopathic Parkinson's Disease Patients from Atypical Parkinsonism Patients.
- Diagnostic Accuracy of each one of the PDx assay's expressed genes for Differentiating Idiopathic Parkinson's Disease Patients from Essential Tremor Patients.
- Diagnostic Accuracy of each one of the PDx assay's expressed genes for Differentiating Idiopathic Parkinson's Disease Patients from Healthy Controls.
|
410 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT02283073 |
PDx001
82/14
TASMC -14-TG-0489-14-TLV-CTIL
1735-14-SMC
0463-14-RMB |
|
November 2014 |
February 2018 |
February 2018 |
November 5, 2014 |
February 23, 2017 |
|
- Rambam Health Care Campus
Haifa, Israel - Rabin Medical Center
Petach Tikvah, Israel - Tel Aviv Sourasky Medical Center
Tel Aviv, Israel - (and 3 more...)
|
| 15 |
NCT02847650 |
Terminated |
Efficacy, Safety and Tolerability of PF-06649751 in Parkinson's Disease Patients at Early Stage of the Disease |
|
- Drug: Placebo
- Drug: PF-06649751
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in the Modified Unified Parkinson's Disease Rating Scale (MDS UPDRS) Score Part III
- Columbia Suicide Severity Rating Scale (C SSRS)
- • Questionnaire for Impulsive Compulsive Disorders in Parkinson's Disease - Rating Scale (QUIP RS)
|
57 |
All |
45 Years to 80 Years (Adult, Senior) |
NCT02847650 |
B7601011
2016-001575-71 |
|
October 17, 2016 |
January 29, 2018 |
January 29, 2018 |
July 28, 2016 |
March 5, 2018 |
|
- St Joseph's Hospital and Medical Center, Barrow Neurology Clinics
Phoenix, Arizona, United States - St. Joseph's Hospital and Medical Center
Phoenix, Arizona, United States - Parkinson's Disease and Movement Disorders Center of Boca Raton
Boca Raton, Florida, United States - (and 34 more...)
|
| 16 |
NCT03137238 |
Not yet recruiting |
Self-motion Perception in Parkinson's Disease |
|
- Other: Investigation of self-perception in Parkinson's disease
|
Observational |
|
- Sheba Medical Center
- Bar-Ilan University, Israel
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Change in multisensory integration
|
100 |
All |
50 Years to 70 Years (Adult, Senior) |
NCT03137238 |
SHEBA-16-3707-SDIK-CTIL |
SMP_PD |
May 1, 2017 |
January 1, 2018 |
August 2018 |
May 2, 2017 |
May 2, 2017 |
|
|
| 17 |
NCT01955616 |
Terminated |
A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation |
|
- Drug: RM-131
- Drug: Placebo
|
Interventional |
Phase 2 |
- Motus Therapeutics, Inc.
- Michael J. Fox Foundation for Parkinson's Research
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Investigate the effects of treatment with RM-131 for 14 days on the frequency of spontaneous bowel movements (SBMs) when administered to patients with Parkinson's Disease (PD) and Chronic Constipation (CC)
- Evaluate the safety and tolerability of multiple doses of RM-131 when administered to patients with PD and CC
- Effect of RM-131 on stool frequency as measured by complete spontaneous bowel movements, stool consistency, straining, completeness of evacuation, abdominal pain, and global patient reported outcomes of severity of constipation and overall relief.
- Assess symptoms of Parkinson's disease using the Unified Parkinson Disease Rating Scale (UPDRS)
|
18 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01955616 |
RM-131-007 |
MOVE-PD |
September 2013 |
May 2015 |
September 2015 |
October 7, 2013 |
September 23, 2016 |
|
- University of Southern California
Los Angeles, California, United States - Colorado Neurological Institute
Englewood, Colorado, United States - University of Florida Ctr for Movement Disorders & Neurorestoration
Gainesville, Florida, United States - (and 10 more...)
|
| 18 |
NCT03146130 |
Not yet recruiting |
Study of the Efficacy of N-acetylcysteine (NAC) on Impulse Control Disorders (TCI) Induced by Dopaminergic Treatments in Parkinson's Disease |
- Impulse Control Disorder
- Parkinson
|
- Biological: Variation of hyper dopaminergic behaviors of Parkinson's disease
|
Interventional |
Phase 3 |
- Centre Hospitalier Universitaire, Amiens
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- To evaluate the variation of the scale of the Behavioral Evaluation of the Parkinson's Disease of Ardouin (ECMP IV)
|
70 |
All |
18 Years and older (Adult, Senior) |
NCT03146130 |
PI2016_843_0002 |
NoISE-PD |
September 20, 2017 |
December 20, 2019 |
December 20, 2019 |
May 9, 2017 |
May 9, 2017 |
|
- CHU Amiens Picardie
Amiens, Picardie, France
|
| 19 |
NCT03366558 |
Recruiting |
Identification of Motor Symptoms Related to Parkinson's Disease Using Motion Tracking Sensors at Home |
|
- Diagnostic Test: UPDRS questionnaires
- Diagnostic Test: 20-step walking test
|
Observational |
|
- Satakunta Central Hospital
- Tampere University of Technology
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Accuracy of the classification of data from movement sensors in relation to the detected motor symptoms
- Accuracy of the detection of the time when the Parkinson medicine was taken
|
150 |
All |
30 Years and older (Adult, Senior) |
NCT03366558 |
5137/31/2016 |
KÄVELI |
March 27, 2018 |
December 31, 2018 |
December 31, 2018 |
December 8, 2017 |
April 19, 2018 |
|
- Satakunta Central Hospital, Unit of Neurology
Pori, Finland
|
| 20 |
NCT03329508 |
Recruiting |
A Phase 3 Study With P2B001 in Subjects With Early Parkinson's |
|
- Drug: P2B001
- Drug: Rasagiline
- Drug: Pramipexole
- Drug: Pramipexole ER
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- change in total Unified Parkinson's Disease Rating Scale (UPDRS) score (defined as sum of parts II and III, scores (0-160).
- Change in Epworth Sleepiness Scale (ESS) score.
- change of Total Parkinson's Disease Questionnaire 39 (PDQ39) score.
|
525 |
All |
35 Years to 75 Years (Adult, Senior) |
NCT03329508 |
P2B001/003 |
|
January 29, 2018 |
September 30, 2019 |
December 30, 2019 |
November 6, 2017 |
April 10, 2018 |
|
- P2B001 Study Scottsdale
Scottsdale, Arizona, United States - P2B001 Study Los Angeles
Los Angeles, California, United States - P2B001 Study Sacramento
Sacramento, California, United States - (and 11 more...)
|
| 21 |
NCT02937324 |
Recruiting |
The CloudUPDRS Smartphone Software in Parkinson's Study. |
|
- Device: CloudUPDRS smartphone software assessment
- Other: Clinical assessment
|
Interventional |
Not Applicable |
- University College, London
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
|
- Validity of smartphone software for home monitoring in Parkinson's disease
- Usability of smartphone software for home monitoring in Parkinson's disease.
- Accuracy of smartphone software for home monitoring in Parkinson's disease.
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02937324 |
16/0062 |
CUSSP |
September 2016 |
September 2017 |
March 2018 |
October 18, 2016 |
October 19, 2016 |
|
- Ashwani Jha
London, United Kingdom
|
| 22 |
NCT01877148 |
Completed
Has Results |
Effects Of tDCS With Physical Therapy On Rehabilitation In Parkinson's Disease |
|
- Device: tDCS
- Behavioral: Physiotherapy
|
Interventional |
Phase 2 |
- Universidade Federal de Pernambuco
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Unified Parkinson´s Disease Rating Scale - UPDRS
- Change From Cortical Excitability Via Single Transcranial Magnetic Stimulation
|
12 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT01877148 |
Parkinson_tDCS_rehabilitation |
|
January 2010 |
September 2012 |
December 2012 |
June 13, 2013 |
May 15, 2015 |
May 15, 2015 |
- Applied Neuroscience Laboratory
Recife, Pernambuco, Brazil
|
| 23 |
NCT03111472 |
Active, not recruiting |
Development and Evaluation of a Guide to Help People With Parkinson's and Their Caregivers to Self-manage Falling |
- Parkinson Disease
- Accidental Fall
|
- Other: Self-management guide for people with Parkinson's who fall and their informal caregivers
|
Interventional |
Not Applicable |
- University of Southampton
- National Institute for Health Research, United Kingdom
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Feasibility and acceptability of the guide
- Health related quality of life of people with Parkinson's as measured on PDQ8
- Caregiver burden of their informal caregivers as measured on the Zarit Burden Interview scale short version
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03111472 |
25364 |
|
May 1, 2017 |
December 2018 |
December 2018 |
April 12, 2017 |
October 26, 2017 |
|
- University of Southampton
Southampton, Hampshire, United Kingdom
|
| 24 |
NCT03301272 |
Recruiting |
Effectiveness of Botox on Reducing Rest Tremor in Parkinson's Disease |
|
- Drug: Onabotulinumtoxin A Injection
- Other: Placebo
|
Interventional |
Phase 1 |
- University of North Carolina, Chapel Hill
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III tremor subscore after onabotulinumtoxinA on a limb afflicted by medically-refractory rest tremor in Parkinson's disease.
- Change in the Action Research Arm Test (ARAT) score after onabotulinumtoxinA on a limb afflicted by medically-refractory rest tremor in Parkinson's disease.
- Change in tremor amplitude in centimeters (cm) and frequency in Hertz (Hz)
|
16 |
All |
40 Years to 75 Years (Adult, Senior) |
NCT03301272 |
15-1831 |
|
March 22, 2018 |
March 2019 |
March 2019 |
October 4, 2017 |
March 27, 2018 |
|
- UNC Hospitals Neurology Clinic
Chapel Hill, North Carolina, United States
|
| 25 |
NCT03337464 |
Completed |
Single Exercise Bout in Parkinson's Disease (PD) |
|
|
Interventional |
Not Applicable |
- Pacific Parkinson's Research Centre
- Pacific Parkinson's Research Centre
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- EEG-EMG coherence
- Motor function
- Cognitive function
- Mood function
|
23 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT03337464 |
H13-00084 |
|
April 2, 2013 |
December 31, 2014 |
December 31, 2014 |
November 9, 2017 |
November 9, 2017 |
|
- Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada
|
| 26 |
NCT02012647 |
Completed |
Subthalamic Deep Brain Stimulation (DBS) in Parkinson's Disease |
|
- Procedure: Transcranial Magnetic Stimulation (TMS)
- Procedure: Motor Physiology Testing
|
Interventional |
Early Phase 1 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Motor Cortex Excitability
- Relation between Unified Parkinson's Disease Rating Scale outcomes and physiological measures
- Transcallosal Pathway Excitability
- Physiological Measures
|
4 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02012647 |
21-2013
40115065-2 |
|
August 2013 |
March 2016 |
June 2016 |
December 16, 2013 |
June 13, 2016 |
|
- University of Florida
Gainesville, Florida, United States
|
| 27 |
NCT02265900 |
Recruiting |
Parkinson's Disease Exercise TMS PET Study |
|
|
Interventional |
Not Applicable |
- Pacific Parkinson's Research Centre
- Pacific Parkinson's Research Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Dopamine release measured by RAC PET
|
30 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT02265900 |
H14-02200 |
|
November 2014 |
November 2018 |
November 2018 |
October 16, 2014 |
November 7, 2017 |
|
- Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada
|
| 28 |
NCT03459586 |
Recruiting |
A Mobile Application for Telerehabilitation in Parkinson's Disease |
|
- Other: 9zest app facilitated exercise
|
Interventional |
Not Applicable |
- 9zest. Inc.
- University of Nevada, Las Vegas
- Boston University
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Incidence of adverse events and falls during exercise using the 9 zest app
- Self-report questionnaire on the feasibility and usability of exercising using the 9 zest app
- The change in the number of times a participant can go from sitting to standing in 30 seconds
- (and 2 more...)
|
300 |
All |
40 Years to 75 Years (Adult, Senior) |
NCT03459586 |
9zest parkinson study |
|
February 28, 2018 |
December 2018 |
December 2018 |
March 9, 2018 |
March 9, 2018 |
|
- Merrill Landers
Las Vegas, Nevada, United States
|
| 29 |
NCT02896816 |
Recruiting |
EMG Modules as a Novel Biomarker of Basal Ganglia Plasticity in Parkinson's Disease |
|
- Other: Surface EMG, MRI and PET Scan
- Other: Surface EMG
|
Interventional |
Not Applicable |
- Spaulding Rehabilitation Hospital
- Michael J. Fox Foundation for Parkinson's Research
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Surface electromyography recording
- Structural MRI
- Functional MRI
- (and 2 more...)
|
40 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02896816 |
2015-P-002526 |
|
May 2016 |
December 2017 |
December 2017 |
September 12, 2016 |
March 22, 2017 |
|
- Spaulding Rehabilitation Hospital
Boston, Massachusetts, United States
|
| 30 |
NCT02360683 |
Recruiting |
Predictive Factors and Subthalamic Stimulation in Parkinson's Disease |
|
- Other: patients with Parkinson's disease
|
Observational |
|
- University Hospital, Lille
- Ministry of Health, France
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Improve of quality of life on PDQ39>20%
- Percentage of motor score MDS-UPDRS III improve under stimulation
- Socio-familial evolution (institutionalization)
- (and 7 more...)
|
1000 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02360683 |
2011_41
2013-A00193-42 |
PREDI-STIM |
November 18, 2013 |
May 2019 |
April 2024 |
February 10, 2015 |
November 9, 2017 |
|
- CHU Hôpital NORD
Amiens, France - Hôpital Pierre Wertheimer
Bron, France - Chu Gabriel-Montpied
Clermont-Ferrand, France - (and 12 more...)
|
| 31 |
NCT02038959 |
Completed
Has Results |
Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes |
|
|
Interventional |
Not Applicable |
- University of Rochester
- Patient-Centered Outcomes Research Institute
- National Parkinson Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Feasibility of Virtual Visits for Parkinson Disease
- Change From Baseline in the Quality of Life Measured by Parkinson Disease Questionnaire 39
- Change in EQ-5D Index Value
- (and 8 more...)
|
210 |
All |
30 Years and older (Adult, Senior) |
NCT02038959 |
AD-12-11-4701 |
|
March 2014 |
August 2016 |
August 2016 |
January 17, 2014 |
January 27, 2017 |
January 27, 2017 |
- University of California San Francisco
San Francisco, California, United States - The Parkinson's Institute and Clinical Center
Sunnyvale, California, United States - University of Florida
Gainsville, Florida, United States - (and 17 more...)
|
| 32 |
NCT02855021 |
Not yet recruiting |
Prediction of Dementia in Parkinson's Disease by Measuring Cerebral Metabolism With PET Scan |
|
|
Interventional |
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Onset of dementia authenticated by a neuropsychological assessment (MDS Task Force criteria)
- Regional cerebral glucose consumption in the parietal lobes studied with fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and regional glucose consumption in the caudate nucleus and prefrontal areas studied with FDG PET
- Determination of cerebral blood flow (CBF) by arterial spin labelling (ASL) perfusion 3Tesla (3T) Magnetic Resonance Imaging (MRI)
- (and 6 more...)
|
138 |
All |
45 Years to 75 Years (Adult, Senior) |
NCT02855021 |
P140306 |
PREDEMPARK |
September 2016 |
September 2019 |
September 2019 |
August 4, 2016 |
August 4, 2016 |
|
- Henri Mondor Hospital
Creteil, France
|
| 33 |
NCT01747655 |
Completed
Has Results |
A Post Marketing Observational Study of Activities of Daily Living in Advanced Parkinson's Disease Patients With Early Troublesome Motor Fluctuations and Treated With Duodopa - a Multi-country Study |
|
|
Observational |
|
- AbbVie (prior sponsor, Abbott)
- AbbVie
|
Industry |
- Time Perspective: Prospective
|
- Unified Parkinson's Disease Rating Scale (UPDRS) II (Activities of Daily Living) Score: Mean Change From Baseline to 12 Months After Hospital Discharge
- Unified Parkinson's Disease Rating Scale (UPDRS) II (Activities of Daily Living) Score: Mean Change From Baseline to 3, 6, and 12 Months After Hospital Discharge
- Percentage of Participants Who Continued With Jejunal Extension Tube of the Percutaneous Endoscopic Gastrostomy (PEG-J) Treatment
- (and 13 more...)
|
64 |
All |
18 Years and older (Adult, Senior) |
NCT01747655 |
P13-893 |
MONOTREAT |
February 2013 |
July 2015 |
July 2015 |
December 12, 2012 |
October 13, 2016 |
October 13, 2016 |
|
| 34 |
NCT02864004 |
Recruiting |
Apomorphine Pump in Early Stage of Parkinson's Disease (EARLY-PUMP) |
|
- Drug: Apomorphine
- Other: Best Medical Treatment
|
Interventional |
Phase 3 |
- Rennes University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Difference in the Parkinson's Disease Quality of Life Questionnaire (PDQ39) summary index between the baseline assessment and the assessment at 12 months' follow up
- Change in the Patient Global Impression of Change (PGIC)
- Change in the Neurologist Global Impression of change (CGI-I)
- (and 23 more...)
|
192 |
All |
18 Years to 65 Years (Adult) |
NCT02864004 |
35RC15_9724_EARLY-PUMP |
EARLY-PUMP |
March 3, 2017 |
March 3, 2020 |
September 3, 2021 |
August 11, 2016 |
April 17, 2018 |
|
- Aix en Provence Hospital
Aix en Provence, France - Amiens University Hospital
Amiens, France - Pellegrin University Hospital
Bordeaux, France - (and 18 more...)
|
| 35 |
NCT00976430 |
Suspended |
Autologous Mesenchymal Stem Cell Transplant for Parkinson's Disease |
|
- Procedure: Autologous Bone marrow derived stem cells transplant
|
Interventional |
Not Applicable |
- Jaslok Hospital and Research Centre
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement in clinical condition of the patient assessed using UPDRS (UNIFIED PARKINSON'S DISEASE RATING SCALE) and Time Tests.
|
5 |
All |
35 Years to 70 Years (Adult, Senior) |
NCT00976430 |
JHC525 |
|
July 2009 |
November 30, 2011 |
|
September 14, 2009 |
March 9, 2017 |
|
- Jaslok Hospital And Research Centre
Mumbai, Maharashtra, India
|
| 36 |
NCT02168842 |
Active, not recruiting |
Efficacy of Isradipine in Early Parkinson Disease |
|
- Drug: Isradipine
- Drug: Placebo (for Isradipine)
|
Interventional |
Phase 3 |
- University of Rochester
- National Institute of Neurological Disorders and Stroke (NINDS)
- Michael J. Fox Foundation for Parkinson's Research
- The Parkinson Study Group
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Unified Parkinson Disease Rating Scale (UPDRS)
- Motor function
- Cognitive function
- (and 3 more...)
|
336 |
All |
30 Years and older (Adult, Senior) |
NCT02168842 |
STEADY-PD III
U01NS080818-01A1
U01NS080840-01A1 |
|
September 2014 |
November 2018 |
March 2019 |
June 20, 2014 |
March 8, 2017 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Banner Sun Health Research Institute
Sun City, Arizona, United States - The Parkinsons & Movement Disorder Institute
Fountain Valley, California, United States - (and 51 more...)
|
| 37 |
NCT02073981 |
Active, not recruiting |
Observational Study for Non-motor Symptoms and Treatment in Parkinson's Disease Patients |
|
|
Observational |
|
- Kyowa Hakko Kirin Co., Ltd
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Changing of Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)
- Changing of Parkinson's Disease Questionaire-8 (PDQ-8) score.
|
1000 |
All |
20 Years and older (Adult, Senior) |
NCT02073981 |
J-FIRST |
J-FIRST |
March 2014 |
May 2016 |
March 2018 |
February 28, 2014 |
March 15, 2017 |
|
- Juntendo University Hospital
Bunkyo-ku, Tokyo, Japan
|
| 38 |
NCT02217735 |
Completed |
Expressive Writing for Individuals With Parkinson's Disease and Their Caregivers |
- Parkinson's Disease
- Coping Skills
|
- Behavioral: Writing Intervention
|
Interventional |
Not Applicable |
- Virginia Commonwealth University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Parkinson's Disease Quality of Life (PDQ-39)
- Parkinson's Disease Quality of Life Questionnaire (PDQ-39)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02217735 |
HM#13659 |
PDEWS |
August 2011 |
June 2013 |
June 2013 |
August 15, 2014 |
August 19, 2014 |
|
- VCU Parkinson's and Movement Disorders Center
Richmond, Virginia, United States
|
| 39 |
NCT02902510 |
Completed |
Therapeutic Yoga to Improve Function in Parkinson's Disease |
|
- Other: Therapeutic yoga for people with Parkinson's Disease
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change in Movement Disorders Society-Sponsored Revision of the Unified Parkinson's Disease Rating Scale at 8 weeks
- Change in Mini BESTest at 8 weeks
- Change in Functional Gait Assessment at 8 weeks
- (and 5 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02902510 |
Pro00041068 |
|
April 2015 |
December 2015 |
April 2016 |
September 15, 2016 |
September 15, 2016 |
|
|
| 40 |
NCT03454425 |
Recruiting |
A Study to Evaluate the Safety and Efficacy of ExAblate Subthalomotomy for the Treatment of Parkinson's Disease Motor Features |
|
- Device: Exablate Subthalamotomy
- Device: Sham Exablate Subthalamotomy
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Efficacy - MDS-UPDRS
- Safety - Adverse Events
- MDS-UPDRS
- (and 4 more...)
|
40 |
All |
30 Years and older (Adult, Senior) |
NCT03454425 |
PD010 |
|
February 27, 2018 |
December 31, 2019 |
December 31, 2020 |
March 5, 2018 |
March 5, 2018 |
|
- Hospital Universitario HM Puerta Del Sur. CINAC
Móstoles, Madrid, Spain
|
| 41 |
NCT02438033 |
Withdrawn |
Characterizing the Specificity and Stability of Local Field Potentials in the Globus Pallidus Internus of Patients Undergoing Deep Brain Stimulation for Parkinson's Disease |
|
- Device: Medtronic Activa PC+S Sensing Deep Brain Stimulator Generator
|
Interventional |
Phase 1 |
- Nader Pouratian
- Medtronic
- University of California, Los Angeles
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Unified Parkinson's Disease Rating Scale (UPDRS)
- Change in Hoehn and Yahr Scale
- Change in Parkinson's Disease Questionnaire (PDQ-39)
|
0 |
All |
21 Years to 75 Years (Adult, Senior) |
NCT02438033 |
PC PC+S |
|
September 2015 |
September 2016 |
September 2017 |
May 8, 2015 |
February 25, 2016 |
|
|
| 42 |
NCT01835652 |
Completed |
The Effects of Exercise in Parkinson's Disease |
|
- Other: Active Exercise
- Other: Passive Exercise
|
Interventional |
Not Applicable |
- Pacific Parkinson's Research Centre
- Pacific Parkinson's Research Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Basic Science
|
|
18 |
All |
40 Years to 70 Years (Adult, Senior) |
NCT01835652 |
H13-00276 |
PET |
April 2013 |
March 2015 |
March 2015 |
April 19, 2013 |
May 12, 2015 |
|
- Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada
|
| 43 |
NCT01996878 |
Completed |
Genetic Polymorphism and Parkinson's Disease in Taiwanese |
|
|
Observational |
|
- Changhua Christian Hospital
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- single nucleotide polymorphisms in certain candidate genes
|
334 |
All |
Child, Adult, Senior |
NCT01996878 |
CCH060105 |
|
February 2006 |
February 2007 |
October 2013 |
November 27, 2013 |
November 27, 2013 |
|
- Department of Neurology, Chang-Hua Christian Hospital
Chang-Hua, Taiwan
|
| 44 |
NCT02228590 |
Completed |
A Study to Examine APL-130277 in Patients With Parkinson's Disease |
|
|
Interventional |
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Evaluate the efficacy based on time to ON, percent change in UPDRS. Safety as assessed by adverse events, vital signs and ECGs
- Evaluate the efficacy, safety and tolerability of treatment with APL-130277 in 16 patients with Parkinson's Disease (PD).
|
19 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02228590 |
CTH-105 |
|
August 2014 |
December 2014 |
December 2014 |
August 29, 2014 |
February 3, 2017 |
|
- Banner Sun Health Research Institute
Sun City, Arizona, United States - Rocky Mountain Movement Disorders Center
Englewood, Colorado, United States - Parkinson's Disease and Movement Disorders Center of Boca Raton
Boca Raton, Florida, United States - University of South Florida Parkinson's Disease and Movement Disorders Center
Tampa, Florida, United States
|
| 45 |
NCT02476240 |
Completed |
Evaluating the Influence of Externally vs. Internally Focused Exercise on Rehabilitation in Parkinson's Disease |
|
- Behavioral: Parkinson's disease Sensory Attention Focused Exercise
|
Interventional |
Not Applicable |
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Unified Parkinson's disease Rating Scale Part III (UPDRS-III)
- UPDRS-III
- Single and Dual Task Walking
- (and 6 more...)
|
65 |
All |
Child, Adult, Senior |
NCT02476240 |
3983 |
DT-PDSAFEx |
August 2015 |
May 2016 |
May 2016 |
June 19, 2015 |
August 31, 2017 |
|
|
| 46 |
NCT02588924 |
Unknown † |
Study on the Relationship Between Environmental and Occupational Exposure to Metals and Parkinson's Disease |
- Parkinson Disease, Secondary
|
- Other: Second University of Naples
- Other: Neuromed IRCCS
|
Observational |
|
- University of Campania "Luigi Vanvitelli"
- Neuromed IRCCS
|
Other |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- Enrollment
- Sample Collection
- determination by atomic absorption spectroscopy of the concentration of manganese, copper and iron
|
100 |
All |
28 Years to 70 Years (Adult, Senior) |
NCT02588924 |
961 |
|
September 2015 |
September 2016 |
September 2017 |
October 28, 2015 |
October 28, 2015 |
|
- Neuromed IRCCS
Pozzilli, Isernia, Italy - Second University of Naples
Naples, Napoli, Italy
|
| 47 |
NCT02738528 |
Completed |
MENTAL PRACTICE IN MOTOR LEARNING OF BRUSHING AND PARKINSON DISEASE |
|
- Other: Mental practice and brushing guidance in patients with Parkinson Disease
|
Interventional |
Not Applicable |
- Universidade Federal de Pernambuco
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
35 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT02738528 |
CAAE N°. 29242414.2.0000.5208 |
|
September 2014 |
October 2015 |
October 2015 |
April 14, 2016 |
April 14, 2016 |
|
|
| 48 |
NCT03037463 |
Recruiting |
Measuring Parkinson's Disease With Tear Fluid |
- Idiopathic Parkinson Disease
|
|
Observational |
|
- University of Southern California
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Tear protein composition to discriminate between participants with Parkinson's disease and healthy controls
|
130 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT03037463 |
11594 |
|
January 2017 |
January 2019 |
January 2019 |
January 31, 2017 |
March 9, 2017 |
|
- University of Southern California
Los Angeles, California, United States
|
| 49 |
NCT02134795 |
Completed |
A Pilot Study of a Non-Invasive Neuromodulation Device for Treatment of Parkinson's Disease |
|
- Device: TNM (trade name), a form of brainstem Stimulation
|
Interventional |
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Motor UPDRS score (Unified Parkinson's Disease Rating Scale)
- EKG to record beat-to-beat (R-R) interval data
|
6 |
All |
18 Years and older (Adult, Senior) |
NCT02134795 |
SNS-PD-01 |
|
May 2014 |
September 2014 |
September 2014 |
May 9, 2014 |
December 22, 2016 |
|
- Duke University Health System
Durham, North Carolina, United States
|
| 50 |
NCT03384797 |
Recruiting |
Blood Biomarker in Early Parkinson's Disease |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Biological marker of Parkinson's disease
|
34 |
All |
50 Years and older (Adult, Senior) |
NCT03384797 |
Pro00088250 |
|
January 22, 2018 |
April 2019 |
April 2019 |
December 27, 2017 |
March 14, 2018 |
|
- Duke University
Durham, North Carolina, United States
|
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