| 1 |
NCT01662427 |
Completed |
Nocturnal Parkinson's Disease Symptoms Study Group |
|
- Other: Questionaire to assess Noctural Parkinson's Disease Symptoms
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To assess Noctural Parkinson's Disease Symptoms
- To assess quality of life in Parkinson's Disease patient
- To assess quality of life in caregiver of Parkinson's Disease patient
|
300 |
All |
30 Years to 90 Years (Adult, Older Adult) |
NCT01662427 |
6222012 |
|
November 2012 |
August 2013 |
August 2013 |
August 10, 2012 |
August 20, 2013 |
|
- Roongroj Bhidayasiri
Pathumwan, Bangkok, Thailand
|
|
| 2 |
NCT02975193 |
Recruiting |
Neural Correlates of Cognition in Parkinson's Disease |
|
- Behavioral: Computer task assessing cognition
- Behavioral: Impulsive-Compulsive Disorders in Parkinson's Disease
- Behavioral: Montreal Cognitive Assessment
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in behavioral performance
- Change in Score on Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease - Rating Scale (QUIP-RS)
- Change in Score on Montreal Cognitive Assessment (MoCA)
- Local field potential brain signal
|
45 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02975193 |
IRB201601780 |
|
February 1, 2017 |
December 2018 |
February 2019 |
November 29, 2016 |
March 9, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 3 |
NCT03152721 |
Enrolling by invitation |
The Effect of Parkinson Kinetigraph Recordings on the Management and Outcome in Parkinson's Disease |
|
- Device: Parkinson KinetiGraph
- Other: Self assessment
|
Interventional
|
Not Applicable |
- Sahlgrenska University Hospital, Sweden
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Decision to change management
- Actual change of management
- Patient Reported Experience of Care
- (and 17 more...)
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT03152721 |
WestPORTSintervention
PARKreg |
|
April 30, 2017 |
May 30, 2018 |
September 30, 2018 |
May 15, 2017 |
November 30, 2017 |
|
- Sahlgrenska University Hospital
Göteborg, Sweden
|
|
| 4 |
NCT02370134 |
Unknown † |
Development of Parkinson's Glove for Detection and Suppression of Hand Tremor |
|
- Device: Parkinson's glove
- Device: sham glove
|
Interventional
|
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Number of participants who demonstrate the tremor suppression after use parkinson's glove
- Number of Participants who report pain or any adverse events from parkinson's glove
- Determine the severity of pain related with parkinson's glove
|
50 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02370134 |
005/58 |
|
February 2015 |
January 2016 |
May 2017 |
February 24, 2015 |
February 24, 2015 |
|
- Chulalongkorn University Hospital
Pathumwan, Bangkok, Thailand
|
|
| 5 |
NCT02016092 |
Unknown † |
Biomarker Discovery in Parkinson's Disease |
|
|
Observational
|
|
- The Parkinson's Institute
- The Parkinson's Institute
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Biological markers of Parkinson's disease
- Correlation between biologic markers and clinical features of PD
|
400 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02016092 |
ECH-13-24
5258 |
DISCOVERY-PD |
December 2013 |
March 2016 |
June 2016 |
December 19, 2013 |
March 14, 2016 |
|
- The Parkinson's Institute and Clinical Center
Sunnyvale, California, United States
|
|
| 6 |
NCT03466723 |
Not yet recruiting |
miRNAs Profiling in Parkinson's Disease |
|
- Genetic: biomarker identification in Parkinson disease
|
Observational
|
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Identification of novel circulating miRNAs as biomarkers for Parkinson's disease
|
1000 |
All |
30 Years and older (Adult, Older Adult) |
NCT03466723 |
DRPAR01 |
|
June 2018 |
December 2019 |
May 2021 |
March 15, 2018 |
March 19, 2018 |
|
- Neuromed IRCCS
Pozzilli, Molise, Italy
|
|
| 7 |
NCT03241966 |
Recruiting |
Perception, Cognition, and Gait in Parkinson's Disease |
|
|
Observational
|
|
- Boston University Charles River Campus
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Parkinson's Disease Questionnaire (PDQ-39)
|
1536 |
All |
40 Years to 100 Years (Adult, Older Adult) |
NCT03241966 |
1204E |
|
April 1, 2017 |
April 1, 2019 |
April 1, 2019 |
August 8, 2017 |
August 8, 2017 |
|
- Vision and Cognition Laboratory at Boston University
Boston, Massachusetts, United States
|
|
| 8 |
NCT02283073 |
Active, not recruiting |
Study for the Early Diagnosis of Parkinson's Disease |
- Parkinson's Disease, Idiopathic
|
|
Observational
|
|
|
Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- The Diagnostic Accuracy of PDx mRNA Assay in Diagnosing Idiopathic Parkinson's Disease
- Diagnostic Accuracy of each one of the PDx assay's expressed genes for Differentiating Idiopathic Parkinson's Disease Patients from Atypical Parkinsonism Patients.
- Diagnostic Accuracy of each one of the PDx assay's expressed genes for Differentiating Idiopathic Parkinson's Disease Patients from Essential Tremor Patients.
- Diagnostic Accuracy of each one of the PDx assay's expressed genes for Differentiating Idiopathic Parkinson's Disease Patients from Healthy Controls.
|
410 |
All |
40 Years to 80 Years (Adult, Older Adult) |
NCT02283073 |
PDx001
82/14
TASMC -14-TG-0489-14-TLV-CTIL
1735-14-SMC
0463-14-RMB |
|
November 2014 |
February 2018 |
February 2018 |
November 5, 2014 |
February 23, 2017 |
|
- Rambam Health Care Campus
Haifa, Israel - Rabin Medical Center
Petach Tikvah, Israel - Tel Aviv Sourasky Medical Center
Tel Aviv, Israel - (and 3 more...)
|
|
| 9 |
NCT03105401 |
Recruiting |
Phenomenological and Psychopathological Factors Associated to Hallucinations in Parkinson's Disease |
|
- Other: Assessment of hallucinations in Parkinson's disease
|
Observational
|
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- Hallucinations Prevalence
|
80 |
All |
18 Years and older (Adult, Older Adult) |
NCT03105401 |
69HCL17_0137 |
HALLUPARK |
May 15, 2017 |
January 15, 2019 |
January 15, 2019 |
April 10, 2017 |
February 19, 2018 |
|
- Hôpital des Charpennes. Centre de Recherche Clinique - vieillissement, cerveau, fragilité
Villeurbanne, France
|
|
| 10 |
NCT01877148 |
Completed
Has Results |
Effects Of tDCS With Physical Therapy On Rehabilitation In Parkinson's Disease |
|
- Device: tDCS
- Behavioral: Physiotherapy
|
Interventional
|
Phase 2 |
- Universidade Federal de Pernambuco
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Unified Parkinson´s Disease Rating Scale - UPDRS
- Change From Cortical Excitability Via Single Transcranial Magnetic Stimulation
|
12 |
All |
40 Years to 80 Years (Adult, Older Adult) |
NCT01877148 |
Parkinson_tDCS_rehabilitation |
|
January 2010 |
September 2012 |
December 2012 |
June 13, 2013 |
May 15, 2015 |
May 15, 2015 |
- Applied Neuroscience Laboratory
Recife, Pernambuco, Brazil
|
|
| 11 |
NCT02012647 |
Completed |
Subthalamic Deep Brain Stimulation (DBS) in Parkinson's Disease |
|
- Procedure: Transcranial Magnetic Stimulation (TMS)
- Procedure: Motor Physiology Testing
|
Interventional
|
Early Phase 1 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Motor Cortex Excitability
- Relation between Unified Parkinson's Disease Rating Scale outcomes and physiological measures
- Transcallosal Pathway Excitability
- Physiological Measures
|
4 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02012647 |
21-2013
40115065-2 |
|
August 2013 |
March 2016 |
June 2016 |
December 16, 2013 |
June 13, 2016 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 12 |
NCT02763683 |
Recruiting |
Dementia in Parkinson Disease |
|
|
Observational
|
|
- Washington University School of Medicine
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Investigations of Dementia in Parkinsons Disease
|
320 |
All |
50 Years and older (Adult, Older Adult) |
NCT02763683 |
201512032 |
PIB |
June 2016 |
March 2030 |
March 2030 |
May 5, 2016 |
November 6, 2017 |
|
- Washington University in St. Louis
Saint Louis, Missouri, United States
|
|
| 13 |
NCT01532986 |
Completed |
Randomized Trial to Test the "Coordinated Care for Health Promotion and Activities in Parkinson's Disease" Intervention in the Veterans Administration |
|
- Other: Coordinated care management for Parkinson's disease
- Other: Educational handout
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Change from Baseline in Adherence to the guidelines for Parkinson's disease care at 18 months
- Health Utilities Index (HUI)
- General Self-Efficacy Scale (GSES)
- (and 21 more...)
|
345 |
All |
18 Years and older (Adult, Older Adult) |
NCT01532986 |
NRI 11-126 |
CHAPS |
July 9, 2012 |
January 31, 2017 |
April 30, 2017 |
February 15, 2012 |
August 4, 2017 |
|
- VA Loma Linda Healthcare System, Loma Linda, CA
Loma Linda, California, United States - VA Long Beach Healthcare System, Long Beach, CA
Long Beach, California, United States - VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States - (and 2 more...)
|
|
| 14 |
NCT03301272 |
Recruiting |
Effectiveness of Botox on Reducing Rest Tremor in Parkinson's Disease |
|
- Drug: Onabotulinumtoxin A Injection
- Other: Placebo
|
Interventional
|
Phase 1 |
- University of North Carolina, Chapel Hill
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III tremor subscore after onabotulinumtoxinA on a limb afflicted by medically-refractory rest tremor in Parkinson's disease.
- Change in the Action Research Arm Test (ARAT) score after onabotulinumtoxinA on a limb afflicted by medically-refractory rest tremor in Parkinson's disease.
- Change in tremor amplitude in centimeters (cm) and frequency in Hertz (Hz)
|
16 |
All |
40 Years to 75 Years (Adult, Older Adult) |
NCT03301272 |
15-1831 |
|
March 22, 2018 |
March 2019 |
March 2019 |
October 4, 2017 |
March 27, 2018 |
|
- UNC Hospitals Neurology Clinic
Chapel Hill, North Carolina, United States
|
|
| 15 |
NCT02038959 |
Completed
Has Results |
Connect.Parkinson: Connecting Individuals With Parkinson Disease to Specialists in Their Homes |
|
|
Interventional
|
Not Applicable |
- University of Rochester
- Patient-Centered Outcomes Research Institute
- National Parkinson Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Feasibility of Virtual Visits for Parkinson Disease
- Change From Baseline in the Quality of Life Measured by Parkinson Disease Questionnaire 39
- Change in EQ-5D Index Value
- (and 8 more...)
|
210 |
All |
30 Years and older (Adult, Older Adult) |
NCT02038959 |
AD-12-11-4701 |
|
March 2014 |
August 2016 |
August 2016 |
January 17, 2014 |
January 27, 2017 |
January 27, 2017 |
- University of California San Francisco
San Francisco, California, United States - The Parkinson's Institute and Clinical Center
Sunnyvale, California, United States - University of Florida
Gainsville, Florida, United States - (and 17 more...)
|
|
| 16 |
NCT03111472 |
Active, not recruiting |
Development and Evaluation of a Guide to Help People With Parkinson's and Their Caregivers to Self-manage Falling |
- Parkinson Disease
- Accidental Fall
|
- Other: Self-management guide for people with Parkinson's who fall and their informal caregivers
|
Interventional
|
Not Applicable |
- University of Southampton
- National Institute for Health Research, United Kingdom
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Feasibility and acceptability of the guide
- Health related quality of life of people with Parkinson's as measured on PDQ8
- Caregiver burden of their informal caregivers as measured on the Zarit Burden Interview scale short version
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03111472 |
25364 |
|
May 1, 2017 |
December 2018 |
December 2018 |
April 12, 2017 |
October 26, 2017 |
|
- University of Southampton
Southampton, Hampshire, United Kingdom
|
|
| 17 |
NCT02937688 |
Recruiting |
Deep Brain Stimulation (DBS) for Parkinson's Disease International Study |
|
- Device: Medtronic DBS Therapy for Parkinson's disease
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in Parkinson's disease-related quality of life, as measured by the Parkinson's Disease Questionnaire (PDQ-8).
- Change in motor score, as measured by the Unified Parkinson's Disease Rating Scale (UPDRS) III, off medication
|
264 |
All |
22 Years and older (Adult, Older Adult) |
NCT02937688 |
1678 |
REACH-PD |
July 26, 2017 |
April 2021 |
April 2021 |
October 18, 2016 |
May 30, 2018 |
|
- Hospital Universitário Cajuru
Curitiba, Parana, Brazil - Santa Casa de Misericordia de Belo Horizonte
Belo Horizonte, Brazil - Hospital Sao Rafael - Monte Tabor
Salvador, Brazil - (and 8 more...)
|
|
| 18 |
NCT01747655 |
Completed
Has Results |
A Post Marketing Observational Study of Activities of Daily Living in Advanced Parkinson's Disease Patients With Early Troublesome Motor Fluctuations and Treated With Duodopa - a Multi-country Study |
|
|
Observational
|
|
- AbbVie (prior sponsor, Abbott)
- AbbVie
|
Industry |
- Time Perspective: Prospective
|
- Unified Parkinson's Disease Rating Scale (UPDRS) II (Activities of Daily Living) Score: Mean Change From Baseline to 12 Months After Hospital Discharge
- Unified Parkinson's Disease Rating Scale (UPDRS) II (Activities of Daily Living) Score: Mean Change From Baseline to 3, 6, and 12 Months After Hospital Discharge
- Percentage of Participants Who Continued With Jejunal Extension Tube of the Percutaneous Endoscopic Gastrostomy (PEG-J) Treatment
- (and 13 more...)
|
64 |
All |
18 Years and older (Adult, Older Adult) |
NCT01747655 |
P13-893 |
MONOTREAT |
February 2013 |
July 2015 |
July 2015 |
December 12, 2012 |
October 13, 2016 |
October 13, 2016 |
|
|
| 19 |
NCT03336307 |
Completed |
Predictors of Gait Improvement in Patients With Parkinson's Disease After Rehabilitation |
- Parkinson Disease
- Movement Disorders
|
- Other: Rehabilitation program
|
Observational
|
|
- University of Roma La Sapienza
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- stance duration (change)
- step length (change)
- Step width (change)
- (and 7 more...)
|
36 |
All |
48 Years to 80 Years (Adult, Older Adult) |
NCT03336307 |
s001 |
|
May 2014 |
April 2017 |
July 2017 |
November 8, 2017 |
November 8, 2017 |
|
- Policlinico Italia Srl
Rome, Lazio, Italy
|
|
| 20 |
NCT02168842 |
Active, not recruiting |
Efficacy of Isradipine in Early Parkinson Disease |
|
- Drug: Isradipine
- Drug: Placebo (for Isradipine)
|
Interventional
|
Phase 3 |
- University of Rochester
- National Institute of Neurological Disorders and Stroke (NINDS)
- Michael J. Fox Foundation for Parkinson's Research
- The Parkinson Study Group
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Unified Parkinson Disease Rating Scale (UPDRS)
- Motor function
- Cognitive function
- (and 3 more...)
|
336 |
All |
30 Years and older (Adult, Older Adult) |
NCT02168842 |
STEADY-PD III
U01NS080818-01A1
U01NS080840-01A1 |
|
September 2014 |
November 2018 |
March 2019 |
June 20, 2014 |
April 23, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Banner Sun Health Research Institute
Sun City, Arizona, United States - The Parkinsons & Movement Disorder Institute
Fountain Valley, California, United States - (and 51 more...)
|
|
| 21 |
NCT03384797 |
Recruiting |
Blood Biomarker in Early Parkinson's Disease |
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Biological marker of Parkinson's disease
|
35 |
All |
50 Years and older (Adult, Older Adult) |
NCT03384797 |
Pro00088250 |
|
January 22, 2018 |
April 2019 |
April 2019 |
December 27, 2017 |
May 16, 2018 |
|
- Duke University
Durham, North Carolina, United States
|
|
| 22 |
NCT03141944 |
Recruiting |
Evolution of Hypodopaminergic Syndrome in Early Parkinson's Disease |
|
- Other: Starkstein scale of Apathy
|
Observational
|
|
- University Hospital, Grenoble
|
Other |
- Observational Model: Cohort
- Time Perspective: Other
|
- Evolution of apathy in Parkinson's disease
- Evolution of hypodopaminergia in Parkinson's disease
- Apparition of hyperdopaminergic symptoms in Parkinson's disease
- (and 6 more...)
|
90 |
All |
33 Years to 72 Years (Adult, Older Adult) |
NCT03141944 |
38RC16.184 |
IMPACT |
February 23, 2017 |
April 2019 |
April 2020 |
May 5, 2017 |
June 4, 2018 |
|
- University Hospital of Grenoble
Grenoble, France - Hôpital Neurologique Pierre Wertheimer
Lyon, France - Centre Expert Régional pour la maladie de Parkinson
Poitiers, France - Hôpital de Hautepierre
Strasbourg, France
|
|
| 23 |
NCT03459586 |
Recruiting |
A Mobile Application for Telerehabilitation in Parkinson's Disease |
|
- Other: 9zest app facilitated exercise
|
Interventional
|
Not Applicable |
- 9zest. Inc.
- University of Nevada, Las Vegas
- Boston University
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Incidence of adverse events and falls during exercise using the 9 zest app
- Self-report questionnaire on the feasibility and usability of exercising using the 9 zest app
- The change in the number of times a participant can go from sitting to standing in 30 seconds
- (and 2 more...)
|
300 |
All |
40 Years to 75 Years (Adult, Older Adult) |
NCT03459586 |
9zest parkinson study |
|
February 28, 2018 |
December 2018 |
December 2018 |
March 9, 2018 |
March 9, 2018 |
|
- Merrill Landers
Las Vegas, Nevada, United States
|
|
| 24 |
NCT02701621 |
Completed |
Aquatic Therapy Versus Land-Based Therapy for the Treatment of Balance Dysfunction in Parkinson's Disease |
|
- Other: MIRT-AT
- Other: MIRT
|
Interventional
|
Not Applicable |
- Ospedale Generale Di Zona Moriggia-Pelascini
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Berg Balance Scale
- TUG
- Unified Parkinson's Disease Rating Scale II
- Unified Parkinson's Disease Rating Scale III
|
34 |
All |
60 Years to 80 Years (Adult, Older Adult) |
NCT02701621 |
ATvsLB Therapy for BD in PD |
|
September 2014 |
December 2014 |
December 2014 |
March 8, 2016 |
March 8, 2016 |
|
- Department of Parkinson's Disease and Brain Injury Rehabilitation, of the 'Moriggia-Pelascini' Hospital
Gravedona ed Uniti, Como, Italy
|
|
| 25 |
NCT02864004 |
Recruiting |
Apomorphine Pump in Early Stage of Parkinson's Disease (EARLY-PUMP) |
|
- Drug: Apomorphine
- Other: Best Medical Treatment
|
Interventional
|
Phase 3 |
- Rennes University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Difference in the Parkinson's Disease Quality of Life Questionnaire (PDQ39) summary index between the baseline assessment and the assessment at 12 months' follow up
- Change in the Patient Global Impression of Change (PGIC)
- Change in the Neurologist Global Impression of change (CGI-I)
- (and 23 more...)
|
192 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02864004 |
35RC15_9724_EARLY-PUMP |
EARLY-PUMP |
March 3, 2017 |
March 3, 2020 |
September 3, 2021 |
August 11, 2016 |
April 17, 2018 |
|
- Aix en Provence Hospital
Aix en Provence, France - Amiens University Hospital
Amiens, France - Pellegrin University Hospital
Bordeaux, France - (and 18 more...)
|
|
| 26 |
NCT02847650 |
Terminated |
Efficacy, Safety and Tolerability of PF-06649751 in Parkinson's Disease Patients at Early Stage of the Disease |
|
- Drug: Placebo
- Drug: PF-06649751
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in the Modified Unified Parkinson's Disease Rating Scale (MDS UPDRS) Score Part III
- Columbia Suicide Severity Rating Scale (C SSRS)
- • Questionnaire for Impulsive Compulsive Disorders in Parkinson's Disease - Rating Scale (QUIP RS)
|
57 |
All |
45 Years to 80 Years (Adult, Older Adult) |
NCT02847650 |
B7601011
2016-001575-71 |
|
October 17, 2016 |
January 29, 2018 |
January 29, 2018 |
July 28, 2016 |
March 5, 2018 |
|
- St Joseph's Hospital and Medical Center, Barrow Neurology Clinics
Phoenix, Arizona, United States - St. Joseph's Hospital and Medical Center
Phoenix, Arizona, United States - Parkinson's Disease and Movement Disorders Center of Boca Raton
Boca Raton, Florida, United States - (and 34 more...)
|
|
| 27 |
NCT03137238 |
Not yet recruiting |
Self-motion Perception in Parkinson's Disease |
|
- Other: Investigation of self-perception in Parkinson's disease
|
Observational
|
|
- Sheba Medical Center
- Bar-Ilan University, Israel
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Change in multisensory integration
|
100 |
All |
50 Years to 70 Years (Adult, Older Adult) |
NCT03137238 |
SHEBA-16-3707-SDIK-CTIL |
SMP_PD |
May 1, 2017 |
January 1, 2018 |
August 2018 |
May 2, 2017 |
May 2, 2017 |
|
|
|
| 28 |
NCT01955616 |
Terminated |
A Phase 2 Study to Evaluate the Safety and Efficacy of RM-131 in Patients With Parkinson's Disease & Chronic Constipation |
|
- Drug: RM-131
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Motus Therapeutics, Inc.
- Michael J. Fox Foundation for Parkinson's Research
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Investigate the effects of treatment with RM-131 for 14 days on the frequency of spontaneous bowel movements (SBMs) when administered to patients with Parkinson's Disease (PD) and Chronic Constipation (CC)
- Evaluate the safety and tolerability of multiple doses of RM-131 when administered to patients with PD and CC
- Effect of RM-131 on stool frequency as measured by complete spontaneous bowel movements, stool consistency, straining, completeness of evacuation, abdominal pain, and global patient reported outcomes of severity of constipation and overall relief.
- Assess symptoms of Parkinson's disease using the Unified Parkinson Disease Rating Scale (UPDRS)
|
18 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01955616 |
RM-131-007 |
MOVE-PD |
September 2013 |
May 2015 |
September 2015 |
October 7, 2013 |
September 23, 2016 |
|
- University of Southern California
Los Angeles, California, United States - Colorado Neurological Institute
Englewood, Colorado, United States - University of Florida Ctr for Movement Disorders & Neurorestoration
Gainesville, Florida, United States - (and 10 more...)
|
|
| 29 |
NCT03337464 |
Completed |
Single Exercise Bout in Parkinson's Disease (PD) |
|
|
Interventional
|
Not Applicable |
- Pacific Parkinson's Research Centre
- Pacific Parkinson's Research Centre
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- EEG-EMG coherence
- Motor function
- Cognitive function
- Mood function
|
23 |
All |
40 Years to 80 Years (Adult, Older Adult) |
NCT03337464 |
H13-00084 |
|
April 2, 2013 |
December 31, 2014 |
December 31, 2014 |
November 9, 2017 |
November 9, 2017 |
|
- Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada
|
|
| 30 |
NCT03146130 |
Not yet recruiting |
Study of the Efficacy of N-acetylcysteine (NAC) on Impulse Control Disorders (TCI) Induced by Dopaminergic Treatments in Parkinson's Disease |
- Impulse Control Disorder
- Parkinson
|
- Biological: Variation of hyper dopaminergic behaviors of Parkinson's disease
|
Interventional
|
Phase 3 |
- Centre Hospitalier Universitaire, Amiens
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- To evaluate the variation of the scale of the Behavioral Evaluation of the Parkinson's Disease of Ardouin (ECMP IV)
|
70 |
All |
18 Years and older (Adult, Older Adult) |
NCT03146130 |
PI2016_843_0002 |
NoISE-PD |
September 20, 2017 |
December 20, 2019 |
December 20, 2019 |
May 9, 2017 |
May 9, 2017 |
|
- CHU Amiens Picardie
Amiens, Picardie, France
|
|
| 31 |
NCT03366558 |
Recruiting |
Identification of Motor Symptoms Related to Parkinson's Disease Using Motion Tracking Sensors at Home |
|
- Diagnostic Test: UPDRS questionnaires
- Diagnostic Test: 20-step walking test
|
Observational
|
|
- Satakunta Central Hospital
- Tampere University of Technology
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Accuracy of the classification of data from movement sensors in relation to the detected motor symptoms
- Accuracy of the detection of the time when the Parkinson medicine was taken
|
150 |
All |
30 Years and older (Adult, Older Adult) |
NCT03366558 |
5137/31/2016 |
KÄVELI |
March 27, 2018 |
December 31, 2018 |
December 31, 2018 |
December 8, 2017 |
April 19, 2018 |
|
- Satakunta Central Hospital, Unit of Neurology
Pori, Finland
|
|
| 32 |
NCT03329508 |
Recruiting |
A Phase 3 Study With P2B001 in Subjects With Early Parkinson's |
|
- Drug: P2B001
- Drug: Rasagiline
- Drug: Pramipexole
- Drug: Pramipexole ER
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- change in total Unified Parkinson's Disease Rating Scale (UPDRS) score (defined as sum of parts II and III, scores (0-160).
- Change in Epworth Sleepiness Scale (ESS) score.
- change of Total Parkinson's Disease Questionnaire 39 (PDQ39) score.
|
525 |
All |
35 Years to 75 Years (Adult, Older Adult) |
NCT03329508 |
P2B001/003 |
|
January 29, 2018 |
September 30, 2019 |
December 30, 2019 |
November 6, 2017 |
June 20, 2018 |
|
- P2B001/003 Site Scottsdale
Scottsdale, Arizona, United States - P2B001 site Los Angeles
Los Angeles, California, United States - P2B001/003 Site Sacramento
Sacramento, California, United States - (and 28 more...)
|
|
| 33 |
NCT02937324 |
Recruiting |
The CloudUPDRS Smartphone Software in Parkinson's Study. |
|
- Device: CloudUPDRS smartphone software assessment
- Other: Clinical assessment
|
Interventional
|
Not Applicable |
- University College, London
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
|
- Validity of smartphone software for home monitoring in Parkinson's disease
- Usability of smartphone software for home monitoring in Parkinson's disease.
- Accuracy of smartphone software for home monitoring in Parkinson's disease.
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT02937324 |
16/0062 |
CUSSP |
September 2016 |
September 2017 |
March 2018 |
October 18, 2016 |
October 19, 2016 |
|
- Ashwani Jha
London, United Kingdom
|
|
| 34 |
NCT02045420 |
Unknown † |
Vascular Abnormalities in Idiopathic Parkinson's Disease |
- Idiopathic Parkinson's Disease
|
|
Observational
|
|
- University of Saskatchewan
|
Other |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- Measurement of Vascular Flow within the Internal Jugular Veins(IJVs), External Jugular Veins(EJVs) and Dural Sinus
- Measurement of Brian Iron using MRI Susceptibility Weighted Imaging Iron Quantification tools
|
30 |
All |
Child, Adult, Older Adult |
NCT02045420 |
BIO13-204 |
IPD |
December 2013 |
October 2016 |
March 2017 |
January 24, 2014 |
December 2, 2015 |
|
- University of Saskatchewan
Saskatoon, Saskatchewan, Canada
|
|
| 35 |
NCT03536104 |
Recruiting
New |
Identification of Risk Factors Parkinson's Disease by Convergence Strategy |
|
|
Observational
|
|
- University Hospital, Lille
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Significant variations in the frequencies of gene polymorphisms and the risk of developing Parkinson's disease
|
2220 |
All |
18 Years and older (Adult, Older Adult) |
NCT03536104 |
2008_0811
2008-A00219-46 |
CONVERGENCE |
December 2008 |
December 2018 |
December 2018 |
May 24, 2018 |
May 24, 2018 |
|
- Hôpital Roger Salengro, CHRU de Lille
Lille, France
|
|
| 36 |
NCT02265900 |
Recruiting |
Parkinson's Disease Exercise TMS PET Study |
|
|
Interventional
|
Not Applicable |
- Pacific Parkinson's Research Centre
- Pacific Parkinson's Research Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Dopamine release measured by RAC PET
|
30 |
All |
40 Years to 80 Years (Adult, Older Adult) |
NCT02265900 |
H14-02200 |
|
November 2014 |
November 2018 |
November 2018 |
October 16, 2014 |
November 7, 2017 |
|
- Pacific Parkinson's Research Centre
Vancouver, British Columbia, Canada
|
|
| 37 |
NCT02476240 |
Completed |
Evaluating the Influence of Externally vs. Internally Focused Exercise on Rehabilitation in Parkinson's Disease |
|
- Behavioral: Parkinson's disease Sensory Attention Focused Exercise
|
Interventional
|
Not Applicable |
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Unified Parkinson's disease Rating Scale Part III (UPDRS-III)
- UPDRS-III
- Single and Dual Task Walking
- (and 6 more...)
|
65 |
All |
Child, Adult, Older Adult |
NCT02476240 |
3983 |
DT-PDSAFEx |
August 2015 |
May 2016 |
May 2016 |
June 19, 2015 |
August 31, 2017 |
|
|
|
| 38 |
NCT02406105 |
Recruiting |
An Effectiveness and Toxicity of CyberKnife Based Radiosurgery for Parkinson Disease |
|
- Radiation: Radiosurgical thalamotomy
- Drug: CyberKnife
|
Interventional
|
Phase 2 |
- Maria Sklodowska-Curie Institute - Oncology Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Tremor reduction evaluated using Unified Parkinson's Disease Rating Scale
- Safety of treatment (evaluated using RTOG/EORTC Acute Radiation Morbidity Scoring Criteria and Late Radiation Morbidity Scoring Schema)
- Evaluation of the value of magnetic resonance spectroscopy as a tool for metabolites proportions changes after PD radiosurgery (spectra of metabolites in irradiated volume)
- Implementation of CyberKnife radiosurgery for Parkinson disease patients not eligible for other treatment modality
|
27 |
All |
18 Years and older (Adult, Older Adult) |
NCT02406105 |
FSRSPD-COI-03 |
|
January 2015 |
June 2018 |
December 2020 |
April 2, 2015 |
April 2, 2015 |
|
- Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology Gliwice Branch
Gliwice, Wybrzeze AK 15, Poland
|
|
| 39 |
NCT02896816 |
Recruiting |
EMG Modules as a Novel Biomarker of Basal Ganglia Plasticity in Parkinson's Disease |
|
- Other: Surface EMG, MRI and PET Scan
- Other: Surface EMG
|
Interventional
|
Not Applicable |
- Spaulding Rehabilitation Hospital
- Michael J. Fox Foundation for Parkinson's Research
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Surface electromyography recording
- Structural MRI
- Functional MRI
- (and 2 more...)
|
40 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02896816 |
2015-P-002526 |
|
August 2016 |
December 2018 |
June 2019 |
September 12, 2016 |
April 26, 2018 |
|
- Spaulding Rehabilitation Hospital
Boston, Massachusetts, United States
|
|
| 40 |
NCT00880620 |
Completed
Has Results |
A Study To Evaluate The Safety And Efficacy Of IPX066 In Subjects With Parkinson's Disease |
|
- Drug: Placebo
- Drug: IPX066 95 mg LD
- Drug: IPX066 145 mg LD
- (and 2 more...)
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change From Baseline in the Sum of UPDRS Part II + UPDRS Part III at Week 30
- Summary of Change From Baseline to End of Study in Mean Parkinson's Disease Questionnaire-39 (PDQ-39) Score
|
381 |
All |
30 Years and older (Adult, Older Adult) |
NCT00880620 |
IPX066-B08-05 |
APEX-PD |
April 2009 |
October 2010 |
November 2010 |
April 14, 2009 |
August 17, 2017 |
February 22, 2016 |
- University of Alabama at Birmingham, Dept. of Neurology
Birmingham, Alabama, United States - HOPE Research Institute, LLC
Phoenix, Arizona, United States - Collaborative NeuroScience Network, Inc.
Garden Grove, California, United States - (and 57 more...)
|
|
| 41 |
NCT02360683 |
Recruiting |
Predictive Factors and Subthalamic Stimulation in Parkinson's Disease |
|
- Other: patients with Parkinson's disease
|
Observational
|
|
- University Hospital, Lille
- Ministry of Health, France
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Improve of quality of life on PDQ39>20%
- Percentage of motor score MDS-UPDRS III improve under stimulation
- Socio-familial evolution (institutionalization)
- (and 7 more...)
|
1000 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02360683 |
2011_41
2013-A00193-42 |
PREDI-STIM |
November 18, 2013 |
May 2019 |
April 2024 |
February 10, 2015 |
April 24, 2018 |
|
- CHU Hôpital NORD
Amiens, France - Hôpital Pierre Wertheimer
Bron, France - Chu Gabriel-Montpied
Clermont-Ferrand, France - (and 12 more...)
|
|
| 42 |
NCT02588924 |
Unknown † |
Study on the Relationship Between Environmental and Occupational Exposure to Metals and Parkinson's Disease |
- Parkinson Disease, Secondary
|
- Other: Second University of Naples
- Other: Neuromed IRCCS
|
Observational
|
|
- University of Campania "Luigi Vanvitelli"
- Neuromed IRCCS
|
Other |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- Enrollment
- Sample Collection
- determination by atomic absorption spectroscopy of the concentration of manganese, copper and iron
|
100 |
All |
28 Years to 70 Years (Adult, Older Adult) |
NCT02588924 |
961 |
|
September 2015 |
September 2016 |
September 2017 |
October 28, 2015 |
October 28, 2015 |
|
- Neuromed IRCCS
Pozzilli, Isernia, Italy - Second University of Naples
Naples, Napoli, Italy
|
|
| 43 |
NCT02756676 |
Completed |
Impact of Rehabilitation in Quality of Life in PD |
|
- Procedure: Multidisciplinary Intensive Rehabilitation Treatment (MIRT)
|
Interventional
|
Not Applicable |
- Ospedale Generale Di Zona Moriggia-Pelascini
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Parkinson Disease Questionnaire (PDQ39)
- Unified Parkinson's disease Rating Scale (UPDRS)
- six minute walking test (6MWT)
- (and 3 more...)
|
250 |
All |
Child, Adult, Older Adult |
NCT02756676 |
QoL and rehab in PD |
|
April 2015 |
September 2016 |
December 2016 |
April 29, 2016 |
April 5, 2017 |
|
- Department of Parkinson's Disease and Brain Injury Rehabilitation, of the 'Moriggia-Pelascini' Hospital
Gradevole ed Uniti, Como, Italy
|
|
| 44 |
NCT01782222 |
Completed
Has Results |
Trial to Evaluate The Efficacy Of Rotigotine on Parkinson's Disease-Associated Motor Symptoms And Apathy |
- Idiopathic Parkinson's Disease
|
- Drug: Rotigotine
- Other: Placebo
|
Interventional
|
Phase 4 |
- UCB BIOSCIENCES GmbH
- UCB Pharma
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change From Baseline to the End of the Maintenance Period in the Score of the Apathy Evaluation Scale (AS) Rated by the Patient
- Change From Baseline to the End of the Maintenance Period in the Total Score of the Unified Parkinson's Disease Rating Scale (UPDRS) Parts II (Activities of Daily Living) + III (Motor Symptoms)
- Change From Baseline to the End of the Maintenance Period in the Score of the Apathy Evaluation Scale (AS) Rated by the Caregiver (Where Available)
- (and 6 more...)
|
122 |
All |
18 Years and older (Adult, Older Adult) |
NCT01782222 |
PD0005
2012-002840-26 |
BRIGHT |
February 2013 |
January 2014 |
March 2014 |
February 1, 2013 |
August 4, 2015 |
January 19, 2015 |
- 4320
Birmingham, Alabama, United States - 4309
Oxnard, California, United States - 4306
Ormond Beach, Florida, United States - (and 39 more...)
|
|
| 45 |
NCT02855021 |
Not yet recruiting |
Prediction of Dementia in Parkinson's Disease by Measuring Cerebral Metabolism With PET Scan |
|
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Onset of dementia authenticated by a neuropsychological assessment (MDS Task Force criteria)
- Regional cerebral glucose consumption in the parietal lobes studied with fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) and regional glucose consumption in the caudate nucleus and prefrontal areas studied with FDG PET
- Determination of cerebral blood flow (CBF) by arterial spin labelling (ASL) perfusion 3Tesla (3T) Magnetic Resonance Imaging (MRI)
- (and 6 more...)
|
138 |
All |
45 Years to 75 Years (Adult, Older Adult) |
NCT02855021 |
P140306 |
PREDEMPARK |
September 2016 |
September 2019 |
September 2019 |
August 4, 2016 |
August 4, 2016 |
|
- Henri Mondor Hospital
Creteil, France
|
|
| 46 |
NCT02578849 |
Unknown † |
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia |
|
|
Observational
|
|
- Aarhus University Hospital
- University of Copenhagen
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Noradrenaline release
- Noradrenaline transporters
|
45 |
All |
50 Years to 80 Years (Adult, Older Adult) |
NCT02578849 |
0602_Parkinson´s disease |
NORAPARK |
January 2012 |
January 2016 |
January 2016 |
October 19, 2015 |
October 19, 2015 |
|
- Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital
Aarhus C, Denmark
|
|
| 47 |
NCT01684475 |
Unknown † |
A STUDY TO EVALUATE THE EFFICACY OF CJH1 (CLR4001) IN PARKINSON'S DISEASE |
|
|
Interventional
|
Phase 1
Phase 2 |
- Alexandra Marine and General Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Reduced signs and symptoms of Parkinson's disease
|
21 |
All |
40 Years to 85 Years (Adult, Older Adult) |
NCT01684475 |
CJH1 Trial |
|
September 2012 |
September 2013 |
September 2013 |
September 13, 2012 |
September 13, 2012 |
|
- Gateway Rural Health Research
Goderich, Ontario, Canada
|
|
| 48 |
NCT01757509 |
Completed |
A Randomized Controlled Feasibility Trial to Determine the Effectiveness of Set Dancing for People With Parkinson's Disease |
|
- Other: Intervention group
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Berg Balance Scale (To assess change in balance)
- Unified Parkinson's Disease Rating Scale 3 (UPDRS-3) (To assess changes in motor impairment)
- The Parkinson's Disease Questionnaire (PDQ-39) (To assess change in health related quality of life)
- (and 2 more...)
|
24 |
All |
18 Years and older (Adult, Older Adult) |
NCT01757509 |
ST1 |
|
December 2012 |
August 2013 |
August 2013 |
December 31, 2012 |
August 27, 2013 |
|
- University of Limerick
Limerick, Munster, Ireland
|
|
| 49 |
NCT01573260 |
Completed
Has Results |
Tango for Treatment of Motor and Non-motor Manifestations in Parkinson's Disease. |
|
- Other: Argentinean Tango classes
- Other: Simple pamphlet about the exercise in PD
|
Interventional
|
Early Phase 1 |
- McGill University Health Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Severity of PD (Unified Parkinson Disease Rating Scale - UPDRS, 2008 Version)
- MiniBESTest
- Number of Participants With a Fall in the Past 3 Months Using the Falls Questionnaire From the Canadian Longitudinal Study of Aging
- (and 11 more...)
|
33 |
All |
18 Years and older (Adult, Older Adult) |
NCT01573260 |
GEN-11-261 |
|
April 2012 |
April 2013 |
April 2014 |
April 9, 2012 |
February 1, 2016 |
February 1, 2016 |
- Montreal General Hospital
Montreal, Quebec, Canada
|
|
| 50 |
NCT01428648 |
Withdrawn |
Impact of Dance Therapy on Parkinson's Disease |
|
- Behavioral: Ballroom Dancing Classes
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Effect of ballroom dancing classes on motor function in patients with Parkinson's disease.
- Effect of ballroom dancing classes on depression in patients with Parkinson's disease.
- Effect of ballroom dancing classes on quality of life of patients with Parkinson's disease.
|
0 |
All |
18 Years and older (Adult, Older Adult) |
NCT01428648 |
133272 |
|
August 2012 |
January 2013 |
March 2013 |
September 5, 2011 |
March 4, 2015 |
|
- University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
|
|
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