| 1 |
NCT00044798 |
Completed |
Magnetic Stimulation Therapy for Treating Vascular Depression |
- Depressive Disorder
- Depression
|
- Procedure: Repetitive transcranial magnetic stimulation (rTMS)
- Drug: Citalopram
- Procedure: Sham rTMS
|
Interventional
|
Phase 3 |
- University of Iowa
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Response rates to treatment; relapse rates; the size, number, and location of the vascular lesions; and the amount of regional brain atrophy
- Improvements in activities of daily living, quality of life, and cognitive function
|
132 |
All |
51 Years to 89 Years (Adult, Older Adult) |
NCT00044798 |
R01MH063405
DATR A4-GPX |
rtms |
September 2001 |
March 2007 |
August 2008 |
September 6, 2002 |
September 27, 2013 |
|
- University of Iowa Health Care
Iowa City, Iowa, United States
|
|
| 2 |
NCT03378570 |
Recruiting |
rTMS for MDD: 5.5cm Rule vs. F3 Targeting |
- Major Depressive Disorder
- Depression
|
- Device: Repetitive transcranial magnetic stimulation
|
Interventional
|
Not Applicable |
- Nicholas Trapp
- University of Iowa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Percentage change in MADRS score
- Response and remission rates on MADRS
- Personality measures
- (and 8 more...)
|
200 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT03378570 |
201709834 |
|
May 1, 2018 |
October 2020 |
October 2020 |
December 20, 2017 |
May 3, 2018 |
|
- University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
|
|
| 3 |
NCT00988663 |
Withdrawn |
The Impact of Memantine on Electroconvulsive Therapy (ECT): Will it Improve Response and Protect Against Cognitive Problems? |
- Major Depressive Disorder
|
- Drug: memantine
- Drug: Placebo
|
Interventional
|
Not Applicable |
- Jerrry L Lewis
- University of Iowa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Assessment of whether Memantine protects memory and cognitive impairment caused by ECT.
- Whether memantine will improve response of Depression to Electroconvulsive therapy.
|
0 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00988663 |
Memantine ECT trial |
ECTAug |
November 2009 |
November 2009 |
November 2009 |
October 2, 2009 |
March 24, 2017 |
|
- University of Iowa hosptitals and clinic
Iowa City, Iowa, United States
|
|
| 4 |
NCT02108678 |
Completed |
One-Day Intervention for Depression and Impairment in Migraine Patients |
|
- Behavioral: ACT-ME
- Behavioral: Migraine Education Only
|
Interventional
|
Not Applicable |
- Baylor College of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- HRSD
- SCID-IV
- WHO-DAS-II
- (and 2 more...)
|
104 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02108678 |
201301712 |
ACT |
September 2013 |
September 2017 |
September 2017 |
April 9, 2014 |
December 22, 2017 |
|
- University of Iowa Carver College of Medicine Department of Psychiatry
Iowa City, Iowa, United States
|
|
| 5 |
NCT01775852 |
Completed
Has Results |
Brief Behavioral Intervention for Comorbid Migraine and Depression |
|
|
Interventional
|
Not Applicable |
- Lilian N. Dindo
- University of Iowa
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mean Change in Hamilton Depression Rating Scale (HAM-D) From Baseline to 12 Week Follow-up
- Mean Change Score in HDI (Headache Disability Inventory) From Baseline to 12 Weeks.
- Mean Change on Short Form Health Survey (SF-36) From Baseline to 12 Week Follow-up.
- Mean Change of World Health Organization Disability Assessment (WHO-DAS) From Baseline to 12-week Follow up.
|
45 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT01775852 |
201004763
ICTS-01 |
ACT-IM |
August 2010 |
May 2012 |
August 2013 |
January 25, 2013 |
February 22, 2018 |
September 17, 2015 |
- University of Iowa Hospitals & Clinics
Iowa City, Iowa, United States
|
|
| 6 |
NCT00353223 |
Completed |
Interpersonal Psychotherapy for Depression in People With Heart Failure |
- Depression
- Heart Failure, Congestive
|
- Behavioral: Interpersonal and behavioral psychotherapy
- Behavioral: Attention control (AC) condition
|
Interventional
|
Phase 1
Phase 2 |
- University of Iowa
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Score on the 17-item HRSD
- Health-related quality of life
- Interpersonal functioning
- (and 2 more...)
|
66 |
All |
55 Years and older (Adult, Older Adult) |
NCT00353223 |
R34MH073566
DATR A4-GPS |
|
July 2006 |
June 2010 |
June 2010 |
July 18, 2006 |
June 3, 2013 |
|
- University of Iowa
Iowa City, Iowa, United States
|
|
| 7 |
NCT03053765 |
Enrolling by invitation |
Optimizing Fidelity of Interpersonal Psychotherapy |
|
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- expert evaluation of conduct of IPT using IPT Quality and Adherence Measure
|
80 |
All |
21 Years to 99 Years (Adult, Older Adult) |
NCT03053765 |
R33MH097041 |
|
August 2012 |
August 2019 |
August 2019 |
February 15, 2017 |
May 18, 2018 |
|
- University of Iowa
Iowa City, Iowa, United States
|
|
| 8 |
NCT02213601 |
Completed |
Efficacy of Yoga for Postpartum Depression |
|
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline in depression on the 17-item Hamilton Depression Rating Scale (HDRS) at week 8
- Change from baseline in panic symptoms on the Inventory of Depression and Anxiety Symptoms Panic Scale (IDAS) at week 8
- Change from baseline in social anxiety symptoms on the Inventory of Depression and Anxiety Symptoms Social Anxiety Scale (IDAS) at week 8
- (and 2 more...)
|
57 |
Female |
18 Years to 45 Years (Adult) |
NCT02213601 |
201105725 |
|
June 2011 |
October 2012 |
|
August 11, 2014 |
August 11, 2014 |
|
- University of Iowa
Iowa City, Iowa, United States
|
|
| 9 |
NCT00256412 |
Completed |
Essential Fatty Acids for Major Depression |
|
- Drug: Eicosapentaenoic acid (EPA) 0.7 grams/day or 1.5 grams/day
- Drug: Placebo
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Montgomery-Asberg Depression Rating Scale (MADRS) scores
|
24 |
All |
18 Years to 55 Years (Adult) |
NCT00256412 |
IRB-01 200408033 |
|
October 2005 |
October 2007 |
October 2007 |
November 21, 2005 |
June 5, 2008 |
|
- University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
|
|
| 10 |
NCT00602355 |
Completed
Has Results |
Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression |
|
- Drug: Sertraline
- Drug: Placebo
- Behavioral: Interpersonal psychotherapy (IPT)
- (and 2 more...)
|
Interventional
|
Phase 2 |
- Women and Infants Hospital of Rhode Island
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Hamilton Depression Rating Scale (HAM-D)
- Depression Illness Severity Based on Beck Depression Inventory (BDI)
- Global Illness Severity Based on Clinical Global Impression (CGI) Scale
- (and 2 more...)
|
162 |
Female |
18 Years to 50 Years (Adult) |
NCT00602355 |
R01MH074919
R01MH074636
DSIR 83-ATP |
|
February 2008 |
July 2014 |
July 2014 |
January 28, 2008 |
September 21, 2016 |
September 21, 2016 |
- University of Iowa
Iowa City, Iowa, United States - Women and Infants Hospital
Providence, Rhode Island, United States
|
|
| 11 |
NCT00321269 |
Completed
Has Results |
Depression and Congestive Heart Failure in Outpatients. |
|
- Behavioral: Single Illness Management
- Behavioral: Comorbid Illness Management
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
|
- Beck Depression Inventory II
- Health-Related Quality of Life
|
134 |
All |
45 Years and older (Adult, Older Adult) |
NCT00321269 |
IIR 06-082 |
|
October 2007 |
October 2010 |
December 2010 |
May 3, 2006 |
December 24, 2015 |
October 21, 2015 |
- Iowa City VA Medical Center
Iowa City, Iowa, United States - Harry S. Truman Memorial VA Medical Center
Columbia, Missouri, United States
|
|
| 12 |
NCT00043602 |
Completed |
Clinician Managed Interpersonal Psychotherapy |
- Depression
- Depression, Postpartum
|
- Behavioral: Standard interpersonal psychotherapy (IPT)
- Behavioral: Clinician managed interpersonal psychotherapy (CM-IPT)
|
Interventional
|
Early Phase 1 |
- University of Iowa
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Hamilton Rating Scale for Depression
|
140 |
Female |
18 Years and older (Adult, Older Adult) |
NCT00043602 |
R01MH059668
DSIR 83-ATAS |
|
September 2001 |
December 2007 |
December 2007 |
August 13, 2002 |
September 26, 2013 |
|
- University of Iowa
Iowa City, Iowa, United States
|
|
| 13 |
NCT02121015 |
Completed |
Online Collaborative Learning Intervention to Prevent Perinatal Depression |
|
- Behavioral: Share
- Behavioral: Self-Directed
|
Interventional
|
Not Applicable |
- University of Illinois at Chicago
- Northwestern University
- University of Iowa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in depression symptoms over time as measured by the Inventory of Depression and Anxiety Symptoms (IDAS)
- Usability and satisfaction based on the USE measure
- Diagnosis of Major Depressive Disorder based on the Mini International Neuropsychiatric Interview (MINI)
- Site usage as measured by the number of logins to the site over the course of the intervention
|
210 |
Female |
18 Years and older (Adult, Older Adult) |
NCT02121015 |
1R34MH102478-01 |
|
May 2016 |
November 2017 |
November 2017 |
April 23, 2014 |
February 1, 2018 |
|
- University of Illinois at Chicago
Chicago, Illinois, United States - Northwestern University
Chicago, Illinois, United States - University of Iowa
Iowa City, Iowa, United States
|
|
| 14 |
NCT02929667 |
Recruiting |
Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRI |
|
- Drug: Fluoxetine
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Rup Sainju
- University of Iowa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Study recruitment rate
- Study retention rate
- Change in minute ventilation during hypercapnic ventilatory response (HCVR) testing
- (and 2 more...)
|
100 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02929667 |
201607761 |
|
February 16, 2017 |
February 2019 |
April 2019 |
October 11, 2016 |
September 14, 2018 |
|
- The Univeristy of Iowa Hospitals and Clinics
Iowa City, Iowa, United States - Univeristy of Iowa Hospitals and Clinics
Iowa City, Iowa, United States
|
|
| 15 |
NCT00942721 |
Completed |
Cognitive Behavioral Therapy Delivered Over the Internet for Women With Postpartum Depression |
|
- Behavioral: Web-based CBT for PPD
|
Interventional
|
Phase 1 |
- Oregon Research Institute
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Acceptability and feasibility of the Web-based treatment program for women with postpartum depression
- Clinical utility of the program in ameliorating postpartum depression symptoms
- Women's characteristics that moderate the impact of the program
|
53 |
Female |
18 Years and older (Adult, Older Adult) |
NCT00942721 |
R01MH084931
1R01MH084931-01A1
DSIR 83-ATP |
|
October 2009 |
April 2013 |
April 2013 |
July 21, 2009 |
November 25, 2013 |
|
- University of Iowa
Iowa City, Iowa, United States - Oregon Research Institute
Eugene, Oregon, United States - University of Melbourne
Heidelberg Heights, Victoria, Australia
|
|
| 16 |
NCT00071643 |
Completed |
Preventing Post-Stroke Depression |
- Depression
- Cerebrovascular Accident
|
- Behavioral: Problem Solving Therapy
- Drug: Escitalopram
- Other: Placebo
|
Interventional
|
Not Applicable |
- Robert G. Robinson
- National Institute of Mental Health (NIMH)
- University of Iowa
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of depressive disorders in the study population
- Functional Independence Measure
- Stroke Impact Scale
- Neurocognitive tests of executive functions and speed of information processing
|
201 |
All |
31 Years to 89 Years (Adult, Older Adult) |
NCT00071643 |
200207091
R01MH065134
DATR A4-GPX |
|
September 2002 |
November 2008 |
November 2008 |
October 30, 2003 |
September 5, 2017 |
|
- University of Chicago
Chicago, Illinois, United States - University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States - Burke Rehabilitation Hospital
White Plains, New York, United States
|
|
| 17 |
NCT01337726 |
Completed |
Combined Illness Management and Psychotherapy in Treating Depressed Elders |
- Depression
- Heart Failure
- Chronic Obstructive Pulmonary Disease
|
- Behavioral: Combined Psychotherapy and Illness Management
- Behavioral: Illness Management Only
|
Interventional
|
Not Applicable |
- University of Iowa
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Reduction in depressive symptoms
- Improvement in quality of life/functioning
|
226 |
All |
55 Years and older (Adult, Older Adult) |
NCT01337726 |
R01MH086482 |
COPE |
February 2011 |
March 2016 |
October 2016 |
April 19, 2011 |
April 5, 2017 |
|
- Iowa City VA Health Care System
Iowa City, Iowa, United States - University of Iowa
Iowa City, Iowa, United States
|
|
| 18 |
NCT02746367 |
Active, not recruiting |
Bipolar Proteomic Assay Validation Study |
- Major Depressive Disorder, Bipolar I and Bipolar II
|
- Other: Diagnostic test (LDT)
|
Observational
|
|
- Myriad Genetic Laboratories, Inc.
- University of Minnesota - Clinical and Translational Science Institute
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Agreement between the model derived diagnosis (based on panel of serum proteomic markers) and the clinical diagnosis (confirmed by the SCID DSM-5)
- Self-report clinical rating scales (IDS-SR30, PHQ-9, MDQ, HCL-32 and TEMPS-A)
- Changes in proteomic markers at Week 2 and Week 8
|
261 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02746367 |
EP-001 |
|
March 2016 |
January 2019 |
February 2019 |
April 21, 2016 |
January 9, 2019 |
|
- University of Iowa Health Care, Department of Psychiatry
Iowa City, Iowa, United States - University of Minnesota (UMN) Department of Psychiatry
Minneapolis, Minnesota, United States - Lindner Center of HOPE/University of Cincinnati College of Medicine
Mason, Ohio, United States - (and 2 more...)
|
|
| 19 |
NCT01592695 |
Completed
Has Results |
Tailored Tobacco Quitline for Rural Veterans |
|
- Drug: Nicotine replacement therapy - transdermal nicotine patch
- Behavioral: Tailored behavioral intervention
- Behavioral: Tobacco quit line referral
- (and 10 more...)
|
Interventional
|
Phase 2 |
- University of Iowa
- VA Office of Research and Development
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Treatment Satisfaction
- Number of Participants Abstinent From Tobacco Use
- Alcohol Use
- (and 5 more...)
|
63 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT01592695 |
201203712 |
|
June 2012 |
June 2013 |
June 2013 |
May 7, 2012 |
July 19, 2017 |
July 19, 2017 |
- Iowa City VA Health Care System
Iowa City, Iowa, United States
|
|
| 20 |
NCT03170908 |
Not yet recruiting |
Effective Implementation of Interpersonal Psychotherapy |
|
- Behavioral: Interpersonal Psychotherapy
|
Observational
|
|
- Scott P. Stuart
- National Institute of Mental Health (NIMH)
- University of Iowa
|
Other / NIH |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
|
425 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03170908 |
201705766
1R01MH112624 |
|
July 2018 |
June 2021 |
June 2021 |
May 31, 2017 |
January 10, 2018 |
|
- University of Iowa
Iowa City, Iowa, United States
|
|
| 21 |
NCT03254719 |
Active, not recruiting |
Care Outcomes for Chiropractic Outpatient Veterans |
- Low Back Pain
- PTSD
- Depression
- Anxiety
|
|
Interventional
|
Not Applicable |
- Palmer College of Chiropractic
- University of Iowa
- National Center for Complementary and Integrative Health (NCCIH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Duration of study recruitment
- Diversity of patient demographics
- Number of participants engaged in use of MyHealthEVet
- (and 13 more...)
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03254719 |
COCOV-Aim #3
R34AT008427 |
COCOV |
February 1, 2018 |
November 2, 2018 |
June 30, 2019 |
August 18, 2017 |
December 25, 2018 |
|
- VA Community Based Outpatient Clinic
Coralville, Iowa, United States - Palmer Center for Chiropractic Research
Davenport, Iowa, United States - Iowa City Veterans Affairs Health Care System
Iowa City, Iowa, United States - The Spine Institute for Quality
Oskaloosa, Iowa, United States
|
|
| 22 |
NCT00260182 |
Unknown † |
Genetics of Recurrent Early Onset Major Depression |
|
|
Observational
|
|
- National Institute of Mental Health (NIMH)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
|
1500 |
All |
21 Years to 70 Years (Adult, Older Adult) |
NCT00260182 |
R01MH061686-02
R01MH059542
R01MH059552
R01MH075131
R01MH059541
R01MH060912
DNBBS 7G-GRR |
|
October 2005 |
June 2009 |
June 2009 |
December 1, 2005 |
January 4, 2011 |
|
- Stanford University
Palo Alto, California, United States - Howard University
Washington, District of Columbia, United States - Rush University Medical Center
Chicago, Illinois, United States - (and 3 more...)
|
|
| 23 |
NCT03539068 |
Active, not recruiting |
Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care |
- PTSD
- Depression
- Substance Use Disorder
- Traumatic Brain Injury
|
- Behavioral: WEB-ED+ Treatment Arm
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- VA mental health treatment engagement validated by VA electronic medical record review.
- Shared Decision Making Interface between VA clinician and Veteran validated by VA electronic medical record review
|
2000 |
All |
Child, Adult, Older Adult |
NCT03539068 |
IIR 16-096 |
eSDM |
June 1, 2018 |
May 28, 2021 |
May 30, 2022 |
May 28, 2018 |
January 21, 2019 |
|
- Iowa City VA Health Care System, Iowa City, IA
Iowa City, Iowa, United States
|
|
| 24 |
NCT02489305 |
Completed |
Study to Evaluate Potential Predictors of Relapse in Participants With Major Depressive Disorder (MDD) |
- Depressive Disorder, Major
|
|
Observational
|
|
- Janssen Research & Development, LLC
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of Participants With Near Term Relapse
|
330 |
All |
18 Years to 64 Years (Adult) |
NCT02489305 |
CR105160
OBSERVEMDD0001 |
|
December 15, 2014 |
May 1, 2018 |
May 1, 2018 |
July 3, 2015 |
October 26, 2018 |
|
- Birmingham, Alabama, United States
- Glendale, California, United States
- Oceanside, California, United States
- (and 22 more...)
|
|
| 25 |
NCT03739203 |
Recruiting |
The Object of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone |
- Major Depressive Disorder
|
- Drug: Cariprazine
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Total score change from baseline to Week 6 in the MADRS (Montgomery-Åsberg Depression Rating Scale)
|
750 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03739203 |
3111-302-001 |
|
November 10, 2018 |
July 9, 2021 |
July 9, 2021 |
November 12, 2018 |
February 7, 2019 |
|
- Harmonex
Dothan, Alabama, United States - Woodland International Research Group
Little Rock, Arkansas, United States - California Pharmaceutical Research Institute
Anaheim, California, United States - (and 32 more...)
|
|
| 26 |
NCT03352453 |
Recruiting |
A Study of Rapastinel for Rapid Treatment of Depression and Suicidality in Major Depressive Disorder |
- Depressive Disorder, Major
|
- Drug: Rapastinel
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Naurex, Inc, an affiliate of Allergan plc
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline in Montgomery-Asberg Depression Rating Scale) MADRS Total Score
- Change from Baseline in Sheehan - Suicidality Tracking Scale (S-STS) Total Score
|
300 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03352453 |
RAP-MD-20 |
|
December 5, 2017 |
January 1, 2020 |
January 1, 2020 |
November 24, 2017 |
December 7, 2018 |
|
- The Board of Trustees of the University of Alabama for the University of Alabama at Birmingham
Birmingham, Alabama, United States - Collaborative NeuroScience Network, LLC
Garden Grove, California, United States - Behavioral Research Specialists, LLC
Glendale, California, United States - (and 25 more...)
|
|
| 27 |
NCT00005914 |
Completed |
Genetics of Recurrent Early-Onset Depression |
|
|
Observational
|
|
- National Institute of Mental Health (NIMH)
|
NIH |
- Time Perspective: Retrospective
|
|
|
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT00005914 |
R01MH061686-01
R01MH060912
R01MH059552
R01MH059541
R01MH059542
R01MH061686
R01MH060866
DNBBS 7G-GRR |
|
October 1999 |
|
September 2003 |
June 16, 2000 |
December 17, 2009 |
|
- Rush Presbyterian - Saint Luke's Med Ctr
Chicago, Illinois, United States - Univ of Iowa Hosp and Clinic
Iowa City, Iowa, United States - Johns Hopkins University
Baltimore, Maryland, United States - (and 3 more...)
|
|
| 28 |
NCT03014544 |
Recruiting |
Study to Evaluate the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Battery in Participants With Major Depressive Disorder (MDD) |
- Depressive Disorder, Major
|
- Device: Computer- administered test battery
- Device: Examiner- administered test battery
|
Observational
|
|
- Janssen Research & Development, LLC
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Performance Score on a Cognitive Test Battery Evaluated by Symbol Sorting Test (SST)
- Performance Score on a Cognitive Test Battery Evaluated by Digit Span Forward Test (DSFT)
- Performance Score on a Cognitive Test Battery Evaluated by Digit Span Backward Test (DSBT)
- (and 10 more...)
|
578 |
All |
18 Years to 59 Years (Adult) |
NCT03014544 |
CR108211
NOPRODMDD0003 |
|
October 26, 2016 |
March 8, 2019 |
March 8, 2019 |
January 9, 2017 |
December 17, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - California Pharmaceutical Research Institute, Inc.
Anaheim, California, United States - Southern California Research LLC
Beverly Hills, California, United States - (and 18 more...)
|
|
| 29 |
NCT03321526 |
Active, not recruiting |
A Study to Compare the Efficacy, Safety, and Tolerability of JNJ-42847922 Versus Quetiapine Extended-Release as Adjunctive Therapy to Antidepressants in Adult Participants With Major Depressive Disorder Who Have Responded Inadequately to Antidepressant Therapy |
- Depressive Disorder, Major
|
- Drug: JNJ-42847922
- Drug: Placebo Matching to JNJ-42847922
- Drug: Quetiapine XR
- (and 3 more...)
|
Interventional
|
Phase 2 |
- Janssen Research & Development, LLC
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Time to All-Cause Discontinuation of Study Drug
- Percentage of Participants Achieving Remission at Week 12 and Sustaining Remission at Weeks 18 and 24
- Percentage of Participants Achieving Response at Week 12 and Sustaining Response at Weeks 18 and 24
- (and 31 more...)
|
105 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03321526 |
CR108394
42847922MDD2002 |
|
December 12, 2017 |
March 29, 2019 |
June 25, 2019 |
October 25, 2017 |
February 15, 2019 |
|
- NoesisPharma Research
Phoenix, Arizona, United States - Clinical Research Consortium Arizona
Tempe, Arizona, United States - Woodland Research Northwest
Rogers, Arkansas, United States - (and 47 more...)
|
|
| 30 |
NCT02133001 |
Completed |
A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide |
- Major Depressive Disorder
|
- Drug: Esketamine
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Janssen Research & Development, LLC
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Total Score at Hour 4 Post-administration of Study Treatment on Day 1
- Change From Baseline in Clinician's Assessment of Suicide Risk Based on Suicide Ideation and Behavior Assessment Tool (SIBAT) at Hour 4 post-administration of Study Treatment on Day 1
- Change From Baseline in Beck Scale for Suicidal Ideation (BSS) Total Score at Hour 4 post-administration of Study Treatment on Day 1
- (and 6 more...)
|
68 |
All |
18 Years to 64 Years (Adult) |
NCT02133001 |
CR103162
ESKETINSUI2001 |
|
May 2014 |
February 2016 |
February 2016 |
May 7, 2014 |
October 14, 2016 |
|
- Birmingham, Alabama, United States
- San Diego, California, United States
- Hartford, Connecticut, United States
- (and 11 more...)
|
|
| 31 |
NCT02782104 |
Recruiting |
A Long-term Safety Study of Intranasal Esketamine in Treatment-resistant Depression |
- Depressive Disorder, Treatment-Resistant
|
- Drug: Intranasal Esketamine
|
Interventional
|
Phase 3 |
- Janssen Research & Development, LLC
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Participants With Treatment Emergent Adverse Events (TEAEs)
- Change From Baseline in Systolic and Diastolic Blood Pressure
- Change From Baseline in Heart Rate
- (and 16 more...)
|
1150 |
All |
18 Years and older (Adult, Older Adult) |
NCT02782104 |
CR108149
54135419TRD3008
2015-003578-34 |
SUSTAIN-3 |
June 9, 2016 |
August 6, 2021 |
October 31, 2022 |
May 25, 2016 |
February 11, 2019 |
|
- UAB Department of Psychiatry and Behavioral Neurobiology
Birmingham, Alabama, United States - Preferred Research Partners
Little Rock, Arkansas, United States - Advanced Research Center Inc
Anaheim, California, United States - (and 360 more...)
|
|
| 32 |
NCT02109939 |
Completed |
Genomics Used to Improve DEpression Decisions |
- Major Depressive Disorder (MDD)
|
- Genetic: GeneSight Psychotropic
|
Interventional
|
Phase 4 |
- Assurex Health Inc.
- University of Michigan
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- 17-item Hamilton Depression (HAM-D17) score
- 16-item Quick Inventory of Depression Symptomology (QIDS-C16) scale
- Percentage of responders at Week 8 for HAM-D17
- (and 23 more...)
|
1303 |
All |
18 Years and older (Adult, Older Adult) |
NCT02109939 |
ARX1006 |
GUIDED |
April 2014 |
April 20, 2017 |
July 31, 2017 |
April 10, 2014 |
May 31, 2018 |
|
- Birmingham Psychiatry Pharmaceutical Studies
Birmingham, Alabama, United States - University of Alabama at Birmingham
Birmingham, Alabama, United States - CiTrials
Bellflower, California, United States - (and 58 more...)
|
|
| 33 |
NCT02422186 |
Completed |
A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression |
- Depressive Disorder, Treatment-Resistant
|
- Drug: Esketamine
- Drug: Placebo
- Drug: Duloxetine (Oral Antidepressant)
- (and 3 more...)
|
Interventional
|
Phase 3 |
- Janssen Research & Development, LLC
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Baseline in Montgomery Asberg Depression Rating Scale (MADRS) Total Score at end of Double-Blind Induction Phase
- Change From Baseline in Clinical Global Impression-Severity (CGI-S) Score at end of Double-Blind Induction Phase
- Change From Baseline in Subject-Reported Health-related Quality of Life and Health Status as Assessed by EuroQol-5 Dimension-5 Level (EQ-5D-5L) at end of Double-Blind Induction Phase
- (and 3 more...)
|
139 |
All |
65 Years and older (Older Adult) |
NCT02422186 |
CR107129
ESKETINTRD3005
2014-004588-19 |
TRANSFORM-3 |
August 20, 2015 |
August 10, 2017 |
August 10, 2017 |
April 21, 2015 |
July 18, 2018 |
|
- San Diego, California, United States
- New Haven, Connecticut, United States
- Miami, Florida, United States
- (and 66 more...)
|
|
| 34 |
NCT03185819 |
Recruiting |
Study to Evaluate the Efficacy and Safety of 3 Fixed Doses of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Pediatric Participants Assessed to be at Imminent Risk for Suicide |
- Depressive Disorder, Major
|
- Drug: Intranasal Placebo
- Drug: Midazolam Placebo Solution
- Drug: Midazolam
- Drug: Esketamine
|
Interventional
|
Phase 2 |
- Janssen Research & Development, LLC
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Baseline in Children's Depression Rating Scale-Revised (CDRS-R) Total Score at 24 Hours Post First Dose
|
145 |
All |
12 Years to 17 Years (Child) |
NCT03185819 |
CR108323
2016-004422-42
ESKETINSUI2002 |
|
October 5, 2017 |
October 7, 2021 |
February 7, 2022 |
June 14, 2017 |
February 11, 2019 |
|
- University of California, San Francisco
San Francisco, California, United States - Institute of Living/ Hartford Hospital
Hartford, Connecticut, United States - Yale University
New Haven, Connecticut, United States - (and 52 more...)
|
|
| 35 |
NCT02497287 |
Completed |
A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression |
- Treatment-resistant Depression
|
- Drug: Esketamine (Intranasal Spray)
- Drug: Duloxetine (Oral Antidepressant)
- Drug: Escitalopram (Oral Antidepressant)
- (and 2 more...)
|
Interventional
|
Phase 3 |
- Janssen Research & Development, LLC
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from baseline in Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS) score
- Change from baseline in Cogstate computerized cognitive battery domains and Hopkins Verbal Learning Test-Revised (HVLT-R)
- Incidence of withdrawal symptoms assessed by Physician Withdrawal Checklist (PWC-20)
- (and 18 more...)
|
794 |
All |
18 Years and older (Adult, Older Adult) |
NCT02497287 |
CR107148
ESKETINTRD3004
2014-004587-38 |
SUSTAIN-2 |
September 30, 2015 |
October 28, 2017 |
October 28, 2017 |
July 14, 2015 |
October 26, 2018 |
|
- New Haven, Connecticut, United States
- Miami, Florida, United States
- Marietta, Georgia, United States
- (and 108 more...)
|
|
| 36 |
NCT01763216 |
Active, not recruiting |
Improving Mood in Assisted Living Settings |
- Depressive Symptoms
- Clinical Depression
|
- Other: Road Tour
- Other: Boatload of Crosswords
|
Interventional
|
Not Applicable |
- Marianne Smith
- University of Iowa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Changes in the Patient Health Questionnaire (PHQ-9)
- Changes in the Centers for Epidemiological Studies Depression (CESD) 12-item scale
- Changes in the Useful Field of View (UFOV)
- (and 4 more...)
|
300 |
All |
55 Years and older (Adult, Older Adult) |
NCT01763216 |
201208786 |
|
February 2013 |
November 2016 |
June 2019 |
January 8, 2013 |
January 14, 2019 |
|
- Lakeview Village Retirement
Amana, Iowa, United States - The Fountains Senior Community Living
Bettendorf, Iowa, United States - Carlise Center for Assisted Living
Carlisle, Iowa, United States - (and 29 more...)
|
|
| 37 |
NCT00064467 |
Completed |
Lethargic Depression Study |
- Epilepsy
- Major Depressive Disorder (MDD)
|
- Drug: Extended-release bupropion (HCl)
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- Change from randomization on the Inventory of Depressive Symptomatology, self report and clinician rated.
- Percent of responders. Percent of remitters. Quality of Life Enjoyment and Satisfaction Questionnaire.
|
268 |
All |
18 Years and older (Adult, Older Adult) |
NCT00064467 |
AK130931 |
|
June 2003 |
May 2005 |
May 2005 |
July 10, 2003 |
May 30, 2017 |
|
- GSK Investigational Site
Beverly Hills, California, United States - GSK Investigational Site
Sherman Oaks, California, United States - GSK Investigational Site
Temecula, California, United States - (and 21 more...)
|
|
| 38 |
NCT00069459 |
Completed |
Seasonal Affective Depression (SAD) Study |
|
- Drug: Extended-release Bupropion Hydrochloride
|
Interventional
|
Phase 1 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- End of season depression-free rate.
- Time to onset of a seasonal depressive episode.Change from randomization on SIGH-SAD and HAMD-17.
|
250 |
All |
18 Years and older (Adult, Older Adult) |
NCT00069459 |
100006 |
|
September 23, 2003 |
June 3, 2004 |
June 3, 2004 |
September 26, 2003 |
September 25, 2017 |
|
- GSK Investigational Site
Anchorage, Alaska, United States - GSK Investigational Site
Hamden, Connecticut, United States - GSK Investigational Site
Newark, Delaware, United States - (and 45 more...)
|
|
| 39 |
NCT03380117 |
Active, not recruiting |
Electronic Bridge to Mental Health for College Students |
|
- Behavioral: eBridge Online Counseling
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Change in mental health service utilization
- Adherence to mental health services, as measured by yes/no response for 4-week period.
- Adherence to mental health services, as measured by total # of sessions for 4-week period.
- (and 7 more...)
|
6241 |
All |
18 Years and older (Adult, Older Adult) |
NCT03380117 |
R01MH103244 |
eBridge |
November 11, 2014 |
June 30, 2019 |
June 30, 2019 |
December 20, 2017 |
December 7, 2018 |
|
- Stanford University
Stanford, California, United States - University of Iowa
Iowa City, Iowa, United States - University of Michigan
Ann Arbor, Michigan, United States - University of Nevada-Reno
Reno, Nevada, United States
|
|
| 40 |
NCT02323204 |
Active, not recruiting |
PCORI-1306-02918 Evaluation of Parent-based Programs to Support Children After Traumatic Injury |
- Psychological Trauma
- Depression
- Coping
|
- Behavioral: Link for Injured Kids
- Other: So you've been in an accident
|
Interventional
|
Not Applicable |
- Marizen Ramirez
- The University of Queensland
- Children's Mercy Hospital Kansas City
- (and 4 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Post-traumatic Stress Symptoms (Child post-traumatic stress disorder (PTSD) scale)
- Depressive symptoms (Center for Epidemiologic Studies Depression Scale (CES-D)
- Coping Strategies (Questionnaire)
- (and 2 more...)
|
300 |
All |
10 Years to 17 Years (Child) |
NCT02323204 |
201111728
PCORI-1306-02918 |
|
February 17, 2015 |
March 31, 2018 |
March 31, 2018 |
December 23, 2014 |
December 18, 2017 |
|
- Blank Children's Hospital
Des Moines, Iowa, United States - University of Iowa Hospitals and Clinics
Iowa City, Iowa, United States - Children's Hospitals and Clinics of Minnesota
Minneapolis, Minnesota, United States - Children's Mercy Hospital
Kansas City, Missouri, United States
|
|
| 41 |
NCT00401726 |
Completed
Has Results |
Open-Label, Randomized Study Evaluating Treatment With Venlafaxine Extended-Release Plus Dialogues Time to Talk Program |
- Depressive Disorder, Major
|
- Drug: Venlafaxine ER
- Behavioral: Dialogues Time to Talk Program
|
Interventional
|
Phase 4 |
- Wyeth is now a wholly owned subsidiary of Pfizer
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Patients Responding "Very Satisfied" on Satisfaction With Depression Care Scale (SDCS)
- Change in 17-item Hamilton Depression Scale Score From Baseline to 16 Weeks
- Patient Global Impression of Improvement (PGI-I) Score
- (and 5 more...)
|
537 |
All |
18 Years and older (Adult, Older Adult) |
NCT00401726 |
0600B1-416 |
|
June 2006 |
|
October 2007 |
November 20, 2006 |
April 23, 2012 |
June 29, 2010 |
- Birmingham, Alabama, United States
- Birmingham, Alabama, United States
- Mesa, Arizona, United States
- (and 41 more...)
|
|
| 42 |
NCT03217110 |
Recruiting |
Cerebellar Stimulation and Cognitive Control |
- Schizophrenia
- Autism Spectrum Disorder
- Bipolar Disorder
- (and 2 more...)
|
- Device: Repetitive Transcranial Magnetic Stimulation (rTMS)
- Device: Sham Repetitive Transcranial Magnetic Stimulation (rTMS)
|
Interventional
|
Not Applicable |
- Krystal Parker, PhD
- University of Iowa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Change in disease-specific symptom rating scale, one scale identified for each group (MADRS for bipolar group; PANSS for schizophrenia group; UPDRS in Parkinson's patient group).
- Change in brain rhythms
- Change in cognitive function
- (and 13 more...)
|
200 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT03217110 |
201610712 |
|
November 30, 2017 |
August 1, 2021 |
August 1, 2021 |
July 13, 2017 |
February 20, 2019 |
|
- University of Iowa
Iowa City, Iowa, United States
|
|
| 43 |
NCT01286233 |
Unknown † |
Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32 |
- Breast Cancer
- Depression
- Fatigue
- Sleep Disorders
|
- Drug: Metformin
- Drug: Placebo
|
Observational
|
|
- NSABP Foundation Inc
- National Cancer Institute (NCI)
|
Other / NIH |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Questionnaire scores from patient reported outcome battery regarding fatigue, stress, sleep, depression, and general quality of life
- Questionnaire scores from patient reported comorbid conditions and behavioral risks
- Biological correlates of fatigue (medical and demographic characteristics of pts.)
- (and 2 more...)
|
394 |
Female |
18 Years to 74 Years (Adult, Older Adult) |
NCT01286233 |
NSABP MA.32.F
NSABP-NCIC-CTG-MA.32.F |
|
July 2011 |
September 2016 |
September 2016 |
January 31, 2011 |
September 9, 2015 |
|
- Kaiser Permanente Medical Center - Anaheim/Orange County
Anaheim, California, United States - Kaiser Permanente - Deer Valley
Antioch, California, United States - Kaiser Permanente Medical Center - Baldwin Park
Baldwin Park, California, United States - (and 253 more...)
|
|
| 44 |
NCT03704948 |
Not yet recruiting |
Listening Visits for Emotionally Distressed Mothers of Hospitalized Newborns |
- Nurse Delivered Counseling
- Emotional Distress
|
- Behavioral: Listening Visits
- Behavioral: Standard Care (Social Work)
|
Interventional
|
Not Applicable |
- Lisa Segre
- University of Iowa
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Mean depression symptoms score
|
50 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03704948 |
201805961 |
|
February 15, 2019 |
October 2020 |
October 2021 |
October 15, 2018 |
January 29, 2019 |
|
- University of Iowa Stead Family Children's Hospital
Iowa City, Iowa, United States
|
|
| 45 |
NCT01410669 |
Completed |
Motivational Interviewing Intervention for Intimate Partner Violence |
|
- Behavioral: Motivational interviewing (MI)
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
|
305 |
Female |
18 Years and older (Adult, Older Adult) |
NCT01410669 |
5R49CE000924-03 |
ISIS |
December 2007 |
December 2010 |
December 2010 |
August 5, 2011 |
August 5, 2011 |
|
- Iowa City, Iowa, United States
|
|
| 46 |
NCT00006349 |
Completed |
Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer |
- Cognitive/Functional Effects
- Delirium
- Depression
- (and 2 more...)
|
- Dietary Supplement: vitamin E
- Drug: donepezil hydrochloride
- Other: placebo
|
Interventional
|
Phase 3 |
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Supportive Care
|
- Compare the interval between completion of cancer treatment that included prophylactic cranial irradiation and onset of cognitive decline in patients with small cell lung cancer (SCLC) treated with donepezil and vitamin E vs placebo
- Quality of life
|
9 |
All |
18 Years and older (Adult, Older Adult) |
NCT00006349 |
NCCTG-N99C5
CDR0000068206
NCI-P00-0169 |
|
February 2001 |
January 2005 |
January 2007 |
May 29, 2003 |
July 13, 2016 |
|
- CCOP - Scottsdale Oncology Program
Scottsdale, Arizona, United States - Mayo Clinic
Jacksonville, Florida, United States - CCOP - Illinois Oncology Research Association
Peoria, Illinois, United States - (and 12 more...)
|
|
| 47 |
NCT00046241 |
Completed |
Prevention of Seasonal Affective Disorder |
- Seasonal Affective Disorder
|
- Drug: Extended-release bupropion hydrochloride
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- Time between randomization and onset of a seasonal depressive episode. Proportion of depression-free subjects.
- Change in HAMD-24 and -17 total score. Change in pain score.
|
300 |
All |
18 Years and older (Adult, Older Adult) |
NCT00046241 |
AK130930 |
|
September 2002 |
June 2003 |
June 2003 |
September 25, 2002 |
January 23, 2017 |
|
- GSK Clinical Trials Call Center
Anchorage, Alaska, United States - GSK Clinical Trials Call Center
Hamden, Connecticut, United States - GSK Clinical Trials Call Center
Boise, Idaho, United States - (and 48 more...)
|
|
| 48 |
NCT01892813 |
Active, not recruiting |
Dissemination of a Tailored Tobacco Quitline for Rural Veteran Smokers |
- Nicotine Dependence
- Tobacco Use
|
- Drug: Nicotine replacement therapy - Transdermal nicotine patch
- Drug: Nicotine replacement therapy - Nicotine gum
- Drug: Nicotine replacement therapy - Nicotine lozenge
- (and 10 more...)
|
Interventional
|
Phase 3 |
- Mark Vander Weg
- VA Office of Research and Development
- University of Iowa
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Tobacco use
- Alcohol use
- Depressive symptoms
- (and 3 more...)
|
411 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT01892813 |
201305740 |
|
July 2013 |
January 2018 |
January 2018 |
July 4, 2013 |
July 11, 2017 |
|
- Iowa City VA Healthcare System
Iowa City, Iowa, United States
|
|
| 49 |
NCT00627029 |
Unknown † |
Evaluation of Programs of Coordinated Care and Disease Management |
- Congestive Heart Failure
- Diabetes
- Coronary Artery Disease
- (and 6 more...)
|
- Behavioral: Care Coordination
|
Interventional
|
Not Applicable |
- Mathematica Policy Research, Inc.
- Centers for Medicare and Medicaid Services
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Medicare program expenditures
- Claims-based and patient-reported quality of care
|
18277 |
All |
Child, Adult, Older Adult |
NCT00627029 |
MPR 8756
CMS 500-95-0047(09 |
Coca |
September 2000 |
August 2015 |
December 2016 |
February 29, 2008 |
October 1, 2015 |
|
- Hospice of the Valley MediCaring Project
Phoenix, Arizona, United States - Georgetown University Medical Center-Mind My Heart Program
Washington, District of Columbia, United States - Quality Oncology/Matria Healthcare
Sunrise, Florida, United States - (and 12 more...)
|
|
| 50 |
NCT03808675 |
Not yet recruiting |
Aerobic Exercise in Parkinson's Disease |
|
- Behavioral: Aerobic walking
- Behavioral: Usual care with PD specific health education
|
Interventional
|
Phase 2
Phase 3 |
- VA Office of Research and Development
- University of Iowa
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- OFF period MDS-UPDRS Motor Subscale score
- Percent Increase Score (PIS) on Eriksen's flanker task
- total number of driving safety errors on road test
- (and 17 more...)
|
100 |
All |
40 Years and older (Adult, Older Adult) |
NCT03808675 |
E2987-R
1 I01 RX002987-01A1 |
LTAE-PD |
April 1, 2019 |
March 31, 2023 |
March 31, 2023 |
January 17, 2019 |
January 21, 2019 |
|
- University of Iowa Hospitals & Clinics
Iowa City, Iowa, United States - Iowa City VA Health Care System, Iowa City, IA
Iowa City, Iowa, United States
|
|
| 51 |
NCT02655354 |
Recruiting |
A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity |
- Posttraumatic Stress Disorder
- Depression
- Alcohol-Related Disorders
- (and 8 more...)
|
- Behavioral: Motivational Interviewing
- Behavioral: Cognitive Behavioral Therapy Elements
- Behavioral: Care Management
- (and 11 more...)
|
Interventional
|
Not Applicable |
- University of Washington
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline PTSD Checklist Civilian Over the Course of a Year
- Change from Baseline Patient Health Questionnaire 9 item Depression Scale Over the Course of a Year
- Change from Baseline Alcohol Use Disorders Identification Over the Course of a Year
- (and 7 more...)
|
960 |
All |
18 Years and older (Adult, Older Adult) |
NCT02655354 |
UH3MH106338-02 |
TSOS6 |
October 2015 |
September 2018 |
June 2019 |
January 14, 2016 |
May 20, 2016 |
|
- Honor Health
Scottsdale, Arizona, United States - Cedars Sinai
Beverly Hills, California, United States - U.C. Davis
Sacramento, California, United States - (and 21 more...)
|
|
| 52 |
NCT02349412 |
Active, not recruiting |
Early Palliative Care With Standard Care or Standard Care Alone in Improving Quality of Life of Patients With Incurable Lung or Non-colorectal Gastrointestinal Cancer and Their Family Caregivers |
- Liver Cancer
- Anxiety Disorder
- Depression
- (and 7 more...)
|
- Other: Early palliative care
|
Interventional
|
Phase 3 |
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in FACT-G scores from baseline to 12 weeks between study arms
- Change in QOL on the FACT over time
- Rate of depressive symptoms as per Hospital Anxiety and Depression Scale (HADS) at 12 weeks and over time
- (and 9 more...)
|
405 |
All |
18 Years and older (Adult, Older Adult) |
NCT02349412 |
A221303
U10CA037447
UG1CA189823
NCI-2014-01943 |
|
April 2015 |
July 2017 |
|
January 28, 2015 |
August 13, 2018 |
|
- UC San Diego Moores Cancer Center
La Jolla, California, United States - Queen's Medical Center
Honolulu, Hawaii, United States - University of Chicago Comprehensive Cancer Center
Chicago, Illinois, United States - (and 20 more...)
|
|
| 53 |
NCT01038583 |
Active, not recruiting |
Aspirin in Reducing Events in the Elderly |
- Functional Disability
- Dementia
- Heart Disease
- (and 4 more...)
|
- Drug: 100 mg enteric-coated aspirin
- Drug: Placebo
|
Observational
|
|
- Minneapolis Medical Research Foundation
- National Health and Medical Research Council, Australia
- Bayer
- (and 4 more...)
|
Other / Industry / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The primary endpoint is death from any cause or incident, dementia or persistent physical disability.
- All-cause mortality
- Fatal and non fatal cardiovascular events including a) coronary heart disease death, b) non-fatal MI, c) fatal and non-fatal stroke and d) any hospitalization for heart failure
- (and 6 more...)
|
19114 |
All |
65 Years and older (Older Adult) |
NCT01038583 |
HSR#09-3029
3U01AG029824-07S2 |
ASPREE |
January 2010 |
December 2017 |
January 2019 |
December 24, 2009 |
December 19, 2018 |
|
- The University of Alabama at Birmingham
Birmingham, Alabama, United States - Palo Alto Medical Foundation Research Institute
Palo Alto, California, United States - Howard University
Washington, District of Columbia, United States - (and 44 more...)
|
|
| 54 |
NCT00091169 |
Completed
Has Results |
Levocarnitine in Treating Fatigue in Cancer Patients |
- Fatigue
- Unspecified Adult Solid Tumor, Protocol Specific
|
- Dietary Supplement: levocarnitine
- Other: placebo
|
Interventional
|
Phase 3 |
- ECOG-ACRIN Cancer Research Group
- National Cancer Institute (NCI)
- Eastern Cooperative Oncology Group
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Supportive Care
|
- Mean Score Change in Fatigue Measured With Brief Fatigue Inventory From Baseline to 4 Weeks
- Mean Score Change in Fatigue Measured With FACIT-F From Baseline to 4 Weeks
- Mean Score Change in Depression Measured With CES-D Between 4 Weeks and Baseline
- (and 3 more...)
|
376 |
All |
18 Years and older (Adult, Older Adult) |
NCT00091169 |
E4Z02
U10CA023318
CDR0000384087 |
|
November 2005 |
March 2008 |
May 2011 |
September 8, 2004 |
May 30, 2016 |
May 30, 2016 |
- Veterans Affairs Medical Center - Palo Alto
Palo Alto, California, United States - Stanford Comprehensive Cancer Center - Stanford
Stanford, California, United States - Praxair Cancer Center at Danbury Hospital
Danbury, Connecticut, United States - (and 113 more...)
|
|
| 55 |
NCT01376349 |
Completed
Has Results |
Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms |
- Breast Cancer
- Gynecologic Cancer
|
- Drug: prasterone
- Other: placebo
|
Interventional
|
Phase 3 |
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
- Mayo Clinic
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Supportive Care
|
- Alleviation of the Most Bothersome Vaginal Symptom (Vaginal Dryness or Dyspareunia) Over 12 Weeks
|
464 |
Female |
18 Years and older (Adult, Older Adult) |
NCT01376349 |
NCCTG-N10C1
CDR0000702003
NCI-2011-02677 |
|
July 2011 |
August 2013 |
November 2017 |
June 20, 2011 |
February 7, 2019 |
August 25, 2017 |
- Mayo Clinic Scottsdale
Scottsdale, Arizona, United States - Aurora Presbyterian Hospital
Aurora, Colorado, United States - Boulder Community Hospital
Boulder, Colorado, United States - (and 277 more...)
|
|
| 56 |
NCT01793129 |
Recruiting |
Preemie Hypothermia for Neonatal Encephalopathy |
- Infant, Newborn
- Hypoxia, Brain
- Hypoxia-Ischemia, Brain
- (and 3 more...)
|
- Device: Hypothermia
- Procedure: Normothermic Control
|
Interventional
|
Phase 2
Phase 3 |
- NICHD Neonatal Research Network
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Death or moderate or severe disability
- Number of deaths in the NICU and following discharge
- Differences in MRI findings after cessation of cooling/control obtained
- (and 3 more...)
|
168 |
All |
33 Weeks to 35 Weeks (Child) |
NCT01793129 |
NICHD-NRN-0051
U10HD021364
U10HD040689
U10HD021385
U10HD027851
U10HD027853
U10HD027856
U10HD027904
U10HD027880
U10HD034216
U10HD021373
U10HD040492
U10HD053109
U10HD040461
U10HD068244
U10HD068263
U10HD068270
U10HD068278
U10HD068284
U10HD036790
UG1HD087226 |
|
May 2015 |
August 2020 |
October 2022 |
February 15, 2013 |
February 19, 2019 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Stanford University
Palo Alto, California, United States - Emory University
Atlanta, Georgia, United States - (and 15 more...)
|
|
| 57 |
NCT00614744 |
Completed
Has Results |
Late Hypothermia for Hypoxic-Ischemic Encephalopathy |
- Infant, Newborn
- Hypoxia, Brain
- Hypoxia-Ischemia, Brain
- (and 3 more...)
|
- Procedure: Hypothermia
- Procedure: Normothermic Control
|
Interventional
|
Phase 2
Phase 3 |
- NICHD Neonatal Research Network
- National Center for Research Resources (NCRR)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Death or Moderate or Severe Disability
- Number of Deaths in the NICU and Following Discharge
- Number of Infants With Moderate and Severe Disability
- (and 7 more...)
|
168 |
All |
up to 24 Hours (Child) |
NCT00614744 |
NICHD-NRN-0038
U10HD036790
U10HD021364
U10HD021373
U10HD021385
U10HD027851
U10HD027853
U10HD027856
U10HD027871
U10HD027880
U10HD027904
U10HD034216
U10HD040492
U10HD040689
U10HD053089
U10HD053109
U10HD053119
U10HD053124
UL1RR024139
UL1RR025744
UL1RR024979
U10HD068244
1U10HD068263-01
U10HD068270
U10HD068278
U10HD068284 |
|
April 2008 |
June 2016 |
June 2016 |
February 13, 2008 |
August 7, 2017 |
August 7, 2017 |
- University of Alabama at Birmingham
Birmingham, Alabama, United States - University of California - Los Angeles
Los Angeles, California, United States - Stanford University
Palo Alto, California, United States - (and 19 more...)
|
|
| 58 |
NCT01192776 |
Terminated
Has Results |
Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) |
- Infant, Newborn
- Hypoxia, Brain
- Hypoxia-Ischemia, Brain
- (and 3 more...)
|
- Procedure: Whole-body Cooling
|
Interventional
|
Phase 3 |
- NICHD Neonatal Research Network
- National Center for Research Resources (NCRR)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Death or Moderate to Severe Disability
- Death
- Level of Disability Among Survivors
- (and 9 more...)
|
364 |
All |
up to 6 Hours (Child) |
NCT01192776 |
NICHD-NRN-0043
U10HD021364
U10HD021373
U10HD021385
U10HD027851
U10HD027853
U10HD027856
U10HD027871
U10HD027880
U10HD027904
U10HD034216
U10HD036790
U10HD040492
U10HD040689
U10HD053089
U10HD053109
U10HD053119
U10HD053124
UL1RR024139
UL1RR024979
UL1RR025008
UL1RR025744
UL1RR025747
UL1RR025761
UL1RR025764
U10HD068284
U10HD068278
U10HD068270
U10HD068263
U10HD068244 |
|
September 2010 |
March 2016 |
March 2016 |
September 1, 2010 |
July 17, 2018 |
August 15, 2017 |
- University of Alabama at Birmingham
Birmingham, Alabama, United States - University of California - Los Angeles
Los Angeles, California, United States - Stanford University
Palo Alto, California, United States - (and 16 more...)
|
|
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