| 101 |
NCT02072187 |
Terminated |
Adjunctive Vitamin D in the Treatment of Non-remitted Depression |
|
- Dietary Supplement: Active
- Dietary Supplement: Placebo
|
Interventional |
Phase 3 |
- START Clinic for Mood and Anxiety Disorders
- The Canadian College of Naturopathic Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Depression severity
- Safety
|
9 |
All |
18 Years to 65 Years (Adult) |
NCT02072187 |
0001 |
|
December 2013 |
May 2017 |
May 2017 |
February 26, 2014 |
October 2, 2017 |
|
- START Clinic for Mood and Anxiety Disorders
Toronto, Ontario, Canada
|
| 102 |
NCT01599585 |
Completed
Has Results |
A Randomized Controlled Trial of In-Home Tele-Behavioral Health Care Utilizing Behavioral Activation for Depression |
|
- Behavioral: Behavioral Activation
|
Interventional |
Not Applicable |
- National Center for Telehealth and Technology
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Beck Hopelessness Scale (BHS)
- Adverse Events
- Beck Depression Inventory -II (BDI-II)
|
121 |
All |
18 Years to 65 Years (Adult) |
NCT01599585 |
W81XWH-11-2-0118 |
|
May 2012 |
January 2015 |
October 2016 |
May 16, 2012 |
June 16, 2017 |
June 16, 2017 |
- Portland VA Medical Center
Portland, Oregon, United States - National Center for Telehealth and Technology
Tacoma, Washington, United States
|
| 103 |
NCT01807741 |
Terminated |
Asenapine for Bipolar Depression |
|
- Drug: Asenapine
- Drug: Placebo
|
Interventional |
Phase 2 |
- University of Cincinnati
- University of Louisville
- Merck Sharp & Dohme Corp.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Depression Score
- Change in Depression Response Rate
|
51 |
All |
18 Years to 55 Years (Adult) |
NCT01807741 |
2012-4181 |
|
September 2013 |
July 2017 |
July 2017 |
March 8, 2013 |
July 24, 2017 |
|
- University of Cincinnati
Cincinnati, Ohio, United States
|
| 104 |
NCT03175887 |
Not yet recruiting |
Investigational TMS Treatment for Depression |
- Depression
- Treatment Resistant Depression
|
|
Interventional |
Not Applicable |
- Dartmouth-Hitchcock Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Depressive symptoms measured by the 17-item Hamilton Depression Rating Scale
|
40 |
All |
21 Years to 70 Years (Adult, Senior) |
NCT03175887 |
D17107 |
|
July 2017 |
May 1, 2020 |
May 1, 2020 |
June 5, 2017 |
July 12, 2017 |
|
- Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
|
| 105 |
NCT01292499 |
Unknown † |
Italian Network for the Improvement of Compliance in Depression |
|
- Behavioral: Psychotherapy
- Behavioral: Psychoeducation
- Behavioral: Psychoeducation and psychotherapy
|
Interventional |
Not Applicable |
- Ospedale Amedeo di Savoia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Proportion of patients showing good compliance, as measured at six months from the beginning of the treatment.
|
1264 |
All |
18 Years and older (Adult, Senior) |
NCT01292499 |
RIMAT‐De
RIMAT-De |
|
March 2009 |
January 2012 |
July 2012 |
February 9, 2011 |
February 9, 2011 |
|
- ASL TO2 Amedeo di Savoia
Torino, Italy
|
| 106 |
NCT02731053 |
Completed |
Effectiveness Trial of the French Blues Indicated Depression Prevention Program |
|
- Behavioral: Blues program
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Number of participants who develop a major depressive episode as measured using the SCID diagnostic interview (posttest, 6 month follow-up)
- Change in depressive symptoms as measured using continuous SCID scores (baseline, posttest, 6-month follow-up)
- Change in depressive symptoms as measured using the CES-D questionnaire (baseline, posttest, 6-month follow-up)
- (and 7 more...)
|
72 |
All |
14 Years to 18 Years (Child, Adult) |
NCT02731053 |
FRQSC2016-NP-191870 |
French Blues |
March 2016 |
November 2016 |
November 2016 |
April 7, 2016 |
September 28, 2017 |
|
- Université de Montréal
Montréal, Quebec, Canada
|
| 107 |
NCT02149381 |
Completed |
Psychosocial Group Interventions for Depression |
|
- Behavioral: CBASP
- Behavioral: Befriending
- Other: Treatment as usual
|
Interventional |
Not Applicable |
- University of Eastern Finland
- Jyväskylä Central Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Depression
- Peripheral blood biomarkers
|
82 |
All |
18 Years to 65 Years (Adult) |
NCT02149381 |
PsySysNe |
PsySysNe |
May 2014 |
May 2016 |
May 2016 |
May 29, 2014 |
November 24, 2017 |
|
- University of Eastern Finland
Kuopio, North Savo, Finland
|
| 108 |
NCT01343563 |
Completed |
Trigeminal Nerve Stimulation for Depression: Dose Finding |
|
- Procedure: Trigeminal Nerve Stimulation
|
Interventional |
Phase 2 |
- University of California, Los Angeles
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in Hamilton Depression Rating Scale 17 score
- Change in life functional capacity and quality of life scales
- Changes in Regional Brain Function
- (and 2 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT01343563 |
10-000480 |
|
January 2011 |
January 2012 |
January 2012 |
April 28, 2011 |
February 6, 2013 |
|
- Semel Institute for Neuroscience and Human Behavior at UCLA
Los Angeles, California, United States
|
| 109 |
NCT00557427 |
Terminated |
Hypericum vs Fluoxetine for Mild to Moderate Adolescent Depression |
|
- Drug: hypericum
- Drug: fluoxetine
|
Interventional |
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Rate of clinical response (defined by CDRS-R < 28) at the final/withdrawal visit
- Percentage of patients with a decrease of CDRS-R score > 30 points from baseline
- Final mean CDRS-R score
- (and 2 more...)
|
30 |
All |
12 Years to 18 Years (Child, Adult) |
NCT00557427 |
REM-1/MDA |
|
January 2009 |
November 2010 |
November 2010 |
November 14, 2007 |
June 27, 2011 |
|
- Schneider Children's Medical Center of Israel
Petach Tikva, Israel
|
| 110 |
NCT00256438 |
Unknown † |
Depression and Transcranial Direct Current Stimulation (tDCS) |
|
- Device: Transcranial Direct Current Stimulation
|
Interventional |
Phase 1
Phase 2 |
- The University of New South Wales
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- All measures at baseline and after each 5 treatments:
- Montgomery& Asberg Depression Rating Scale
- Hamilton Psychiatric Rating Scale for Depression
- (and 8 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT00256438 |
05125 |
|
February 2006 |
|
|
November 21, 2005 |
July 10, 2006 |
|
- Black Dog Institute Building, School of Psychiatry, University of NSW
Sydney, New South Wales, Australia
|
| 111 |
NCT01401231 |
Completed |
Behavioral Activation for Perinatal Depression |
- Depression During Pregnancy
|
- Behavioral: Behavioral activation psychotherapy
- Other: Usual care
|
Interventional |
Not Applicable |
- Kaiser Permanente
- National Institute of Mental Health (NIMH)
- HealthPartners Institute
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
163 |
Female |
18 Years and older (Adult, Senior) |
NCT01401231 |
U19MH092201 |
|
August 2011 |
October 2014 |
October 2014 |
July 25, 2011 |
October 13, 2017 |
|
- Group Health Cooperative
Seattle, Washington, United States
|
| 112 |
NCT01014312 |
Completed |
Treatment for Depressed Primary Care Patients |
|
- Behavioral: Depression Care Management (DCM)
- Behavioral: Enhanced Care
|
Interventional |
Not Applicable |
- Weill Medical College of Cornell University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction in severity of depression over 16 weeks as measured by the Montgomery Asberg Depression Rating Scale (MADRS).
- Reduction in disability over 16 weeks as measured by the World Health Organization Disability Scale (WHODAS).
|
11 |
All |
60 Years and older (Adult, Senior) |
NCT01014312 |
P30MH085943-02
P30MH085943
DATR A4-GPC |
|
September 1, 2009 |
April 30, 2015 |
April 30, 2015 |
November 16, 2009 |
February 23, 2017 |
|
- Westchester Medical Group Practices
White Plains, New York, United States
|
| 113 |
NCT01443234 |
Completed |
OxIGen: Oxford Imagery Generation: Investigating the Effects of an Internet Based Computer Program in Depression |
|
- Other: OxIGen
- Other: OxIGen: control version
|
Interventional |
Phase 2 |
- University of Oxford
- Lupina Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change in score on Beck Depression Inventory - II
- Change in score on Quick Inventory of Depressive Symptoms - Self Report
- Change in State-Trait Anxiety Inventory (Trait scale)
- (and 15 more...)
|
150 |
All |
18 Years to 65 Years (Adult) |
NCT01443234 |
11/SC/0278 |
OxIGen |
February 2012 |
April 2013 |
December 2013 |
September 29, 2011 |
January 9, 2014 |
|
- MRC Cognition and Brain Sciences Unit
Cambridge, Cambridgeshire, United Kingdom - Department of Psychiatry, University of Oxford
Oxford, Oxfordshire, United Kingdom
|
| 114 |
NCT02780232 |
Not yet recruiting |
An Internet-based Program for Prevention and Early Intervention of Adolescent Depression |
|
- Behavioral: Cuida tu animo / Care for your mood
|
Interventional |
Not Applicable |
- CES University
- Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS)
- Universidad de Antioquia
- MIDAP Millennium Institute for Research in Depression and Personality
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change from Baseline Depressive Symptomatology at 3 months and 12 months
- Change from Baseline in Health Related Quality of Life at 3 and 12 months
- Change from Baseline in anxious symptoms at 3 and 12 months
- Change from Baseline in of depression at 3 and 12 months
|
600 |
All |
13 Years to 18 Years (Child, Adult) |
NCT02780232 |
CES577 |
|
February 2018 |
March 2019 |
July 2019 |
May 23, 2016 |
May 24, 2016 |
|
|
| 115 |
NCT02112266 |
Completed |
Depression Online Assessment and Therapy |
|
- Other: Mail support
- Other: no mail support
|
Interventional |
Not Applicable |
- University of Zurich
- Makora
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Change of Quality of life
- change of Sleep quality
- change of severity of depression
|
272 |
All |
18 Years to 65 Years (Adult) |
NCT02112266 |
ICBT
2013-0542 |
|
April 2014 |
March 2016 |
March 2016 |
April 11, 2014 |
May 10, 2016 |
|
- University Hospital Zurich - only online recruitment
Zurich, Switzerland
|
| 116 |
NCT02286440 |
Recruiting |
A PK/PD Genetic Variation Treatment Algorithm Versus Treatment As Usual for Adolescent Management Of Depression |
|
- Other: AssureRx GeneSight genotyping results
- Other: Treatment as usual
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Baseline to endpoint change in depression
- Improvement of depressive symptoms
|
276 |
All |
13 Years to 18 Years (Child, Adult) |
NCT02286440 |
14-005547 |
AMOD |
February 2015 |
January 2018 |
January 2018 |
November 7, 2014 |
August 17, 2017 |
|
- Mayo Clinic in Rochester
Rochester, Minnesota, United States - Mayo Clinic
Rochester, Minnesota, United States
|
| 117 |
NCT01238614 |
Completed |
Universal Screening for Maternal Depression With the CHICA System |
|
- Other: CHICA PSF plus JIT
- Other: CHICA maternal depression PSF
- Other: Control
|
Interventional |
Not Applicable |
- Indiana University
- National Library of Medicine (NLM)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Screening
|
- Percent of mothers screening positive for maternal depression.
- Percent of mothers diagnosed with maternal depression
|
3250 |
Female |
Child, Adult, Senior |
NCT01238614 |
MLM-CHICA-K-MD
K22LM009160 |
|
October 2007 |
July 2009 |
September 2010 |
November 10, 2010 |
November 10, 2010 |
|
- CHSR
Indianapolis, Indiana, United States
|
| 118 |
NCT02448433 |
Unknown † |
Phototherapy in Young People With Depression |
|
- Device: Phototherapy light-emitting glasses
|
Interventional |
Not Applicable |
- University of Ottawa
- University of Sydney
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Severity of Depression
- Associations between Changes in Sleep-Wake Profile and Changes in Severity of Depression
- Associations between Initial Sleep-Wake Profile and Changes in Severity of Depression
- (and 2 more...)
|
60 |
All |
13 Years to 30 Years (Child, Adult) |
NCT02448433 |
2015007 |
|
April 2015 |
April 2017 |
|
May 19, 2015 |
May 19, 2015 |
|
- Brain and Mind Research Insitute, The University of Sydney
Camperdown, New South Wales, Australia - Sleep and Depression Research Units, Institute of Mental Health Research, University of Ottawa
Ottawa, Ontario, Canada
|
| 119 |
NCT02998580 |
Recruiting |
Conventional Bilateral rTMS vs. Bilateral Theta Burst Stimulation for Late-Life Depression |
|
- Device: LFR followed by HFL
- Device: cTBS followed by iTBS
|
Interventional |
Not Applicable |
- Centre for Addiction and Mental Health
- University Health Network, Toronto
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change on the Montgomery Asberg Depression Rating Scale (MADRS)
- Remission on the MADRS
|
220 |
All |
60 Years and older (Adult, Senior) |
NCT02998580 |
076-2016 |
|
December 2016 |
December 2020 |
March 2021 |
December 20, 2016 |
November 6, 2017 |
|
- CAMH
Toronto, Ontario, Canada
|
| 120 |
NCT00555698 |
Completed |
Feasibility, Safety and Efficacy of Deep Brain Stimulation for Depression |
|
- Device: Deep Brain Stimulations for Depression
|
Interventional |
Early Phase 1 |
- Ali Rezai, MD
- Medtronic
- The Cleveland Clinic
- Ohio State University
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton Depression Rating Scale (HDRS)
- Inventory for Depressive Symptoms, Self-report (IDS-SR), Clinical Global Impressions (CGI), Patient Global Impressions (PGI), Global Assessment of Functioning (GAF), Social and Occupational Function Assessment Scale (SOFAS), Quality of LIfe Enjoyment and
|
8 |
All |
18 Years to 55 Years (Adult) |
NCT00555698 |
6577 |
|
January 2004 |
February 2011 |
February 2011 |
November 9, 2007 |
March 28, 2017 |
|
- Cleveland Clinic Foundation
Cleveland, Ohio, United States
|
| 121 |
NCT01799551 |
Completed |
Brief Culturally Adapted Cognitive Behaviour Therapy for Depression |
|
|
Interventional |
Not Applicable |
- Pakistan Association of Cognitive Therapists
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Hospital Anxiety and depression Rating Scale- Depression subscale
- Hospital Anxiety and Depression Scale, Anxiety subscale
- Bradford Somatic Inventory
- Brief disability questionnaire
|
140 |
All |
18 Years to 65 Years (Adult) |
NCT01799551 |
PakistanACT |
|
November 2012 |
July 2014 |
July 2014 |
February 27, 2013 |
October 29, 2014 |
|
- Pakistan Association of Cognitive Therapists
Lahore, Pakistan
|
| 122 |
NCT01619631 |
Completed |
Tai Chi Intervention for Chinese Americans With Depression |
|
- Behavioral: 12-week Tai Chi intervention
- Behavioral: Education control group
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
- National Center for Complementary and Integrative Health (NCCIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Major depressive disorder response rate, as determined by Hamilton Rating Scale for Depression (HAM-D 17-item)
- Major depressive disorder remission as measured by DSM-IV and Hamilton Rating Scale for Depression (HAM-D 17-item)
|
94 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01619631 |
2011P001313
R21AT006123-01A1 |
|
February 2012 |
June 2014 |
November 2016 |
June 14, 2012 |
December 1, 2016 |
|
- South Cove Community Health Center
Boston, Massachusetts, United States - Massachusetts General Hospital Depression Clinical and Research Program
Boston, Massachusetts, United States
|
| 123 |
NCT02111811 |
Completed |
Reducing the Burden of Depression Related Disability |
|
- Other: Veterans Work and Health Initiative
|
Interventional |
Not Applicable |
- VA Office of Research and Development
- Tufts Medical Center
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement in work related disability post intervention
- Time lost from work related to depression
- Self rated global health
- Depression severity
|
250 |
All |
18 Years and older (Adult, Senior) |
NCT02111811 |
D1132-R
I01RX001132-01A1 |
|
May 19, 2014 |
June 30, 2017 |
November 30, 2017 |
April 11, 2014 |
February 12, 2018 |
|
- Coatesville VA Medical Center, Coatesville, PA
Coatesville, Pennsylvania, United States - Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Philadelphia, Pennsylvania, United States
|
| 124 |
NCT00517972 |
Withdrawn |
Omacor for Perimenopausal Depression |
|
- Drug: Omacor (omega-3-acid ethyl esters)
|
Interventional |
Phase 2 |
- University of Arizona
- Reliant Pharmaceuticals
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction of the initial HAM-D score by 50% or more at week 8 of the trial.
- Reduction of the HAM-D score to less than 7 at week 8.
- Clinical Global Impression change in score achievement to "very much improved" or "much improved" at week 8.
- Decrease in the Greene Climacteric Scale by 50%.
|
0 |
Female |
40 Years and older (Adult, Senior) |
NCT00517972 |
HSC#06-102;IND76801 |
|
|
|
|
August 17, 2007 |
March 29, 2012 |
|
- Women's Mental Health Program; University of Arizona
Tucson, Arizona, United States
|
| 125 |
NCT00145912 |
Completed |
Primary Care Based Depression Prevention for Adolescents/Young Adults/Young Adults and Young Adults |
|
- Behavioral: MI + CATCH-IT Internet Site
- Behavioral: BA (brief advice) + CATCH-IT Internet site
|
Interventional |
Not Applicable |
- University of Chicago
- National Alliance for Research on Schizophrenia and Depression
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- use of Internet site
- depressed mood and risk factors
|
49 |
All |
15 Years to 21 Years (Child, Adult) |
NCT00145912 |
C.A.T.C.H.-I.T. - 13240B
13240B |
CATCH-IT |
February 2007 |
October 2011 |
October 2011 |
September 5, 2005 |
September 5, 2013 |
|
- The University of Chicago
Chicago, Illinois, United States
|
| 126 |
NCT01128452 |
Terminated |
Safety and Efficacy of EVT 101 in Treatment-Resistant Depression |
|
- Drug: EVT 101
- Drug: Placebo
|
Interventional |
Phase 2 |
- Janssen Research & Development, LLC
- Hoffmann-La Roche
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Safety and Tolerability Profile of EVT 101
- Efficacy of EVT 101 in depression measured using the MADRS score
- Percentage of patients who respond to treatment with study drug
- Percentage of patients who experience remission
|
8 |
All |
18 Years to 55 Years (Adult) |
NCT01128452 |
CR104589
RRA-12001, EVT 101/1012 |
|
June 2010 |
March 2011 |
March 2011 |
May 21, 2010 |
March 28, 2016 |
|
- Evotec Study Site 6
Oceanside, California, United States - Evotec Study Site 19
San Diego, California, United States - Evotec Study Site 15
Tampa, Florida, United States - (and 11 more...)
|
| 127 |
NCT02134678 |
Completed |
Assessing Change in Short Term Therapy for Depression |
|
- Behavioral: self-system therapy
- Behavioral: cognitive therapy
|
Interventional |
Not Applicable |
- University of North Carolina, Greensboro
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in Depressive symptoms - Beck Depression Inventory-II
- Change in Anxiety - Beck Anxiety Inventory
|
56 |
All |
18 Years to 60 Years (Adult) |
NCT02134678 |
1R21MH090414-01A1 |
|
May 2011 |
May 2014 |
November 2014 |
May 9, 2014 |
May 1, 2015 |
|
- UNC Greensboro
Greensboro, North Carolina, United States
|
| 128 |
NCT03285659 |
Not yet recruiting |
Development and Assessment of the Implementation of a Collaborative Care Approach for Depression in Primary Care |
|
- Other: Intervention: INDI Implementation
|
Interventional |
Not Applicable |
- Jordi Gol i Gurina Foundation
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- degree of implementation and capacity for change of the collaborative care model (INDI)
- patient experience about the collaborative care model (INDI)
|
44 |
All |
18 Years and older (Adult, Senior) |
NCT03285659 |
P17/077 |
|
January 1, 2018 |
July 1, 2019 |
December 31, 2019 |
September 18, 2017 |
September 18, 2017 |
|
|
| 129 |
NCT01470092 |
Recruiting |
Tibolone and Placebo in Adjunct to Antidepressant Medication for Women With Menopausal Depression |
|
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Montgomery and Asberg Depression Rating Scale
- The Beck Depression Inventory Second Edition
|
120 |
Female |
45 Years to 65 Years (Adult) |
NCT01470092 |
485/11 |
|
July 2012 |
December 2019 |
December 2019 |
November 11, 2011 |
August 9, 2017 |
|
- The Alfred Hospital
Melbourne, Victoria, Australia
|
| 130 |
NCT02491034 |
Enrolling by invitation |
DESEO: DEpression Screening and Education: Options to Reduce Barriers to Treatment |
|
- Behavioral: Depression Education Intervention
|
Interventional |
Not Applicable |
- The University of Texas at Arlington
- University of Texas Southwestern Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- The number of Hispanic patients diagnosed with depression who went on to begin depression treatment.
|
350 |
All |
18 Years and older (Adult, Senior) |
NCT02491034 |
2015-0336 |
DESEO |
January 2015 |
September 2017 |
September 2017 |
July 7, 2015 |
October 31, 2016 |
|
|
| 131 |
NCT00658476 |
Completed |
Omega-3 Fatty Acids for Treatment of Depression in Adolescents |
|
- Dietary Supplement: Fish Oil
- Behavioral: Cognitive Behavior Therapy
- Other: Placebo
|
Interventional |
Phase 3 |
- Cedars-Sinai Medical Center
- National Alliance for Research on Schizophrenia and Depression
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Child Depression Inventory - CDI
- Hamilton Depression Rating Scale
|
4 |
All |
13 Years to 21 Years (Child, Adult) |
NCT00658476 |
9407 |
PUFA |
November 2006 |
April 2009 |
April 2009 |
April 15, 2008 |
March 27, 2012 |
|
- Cedars-Sinai Medical Center
Los Angeles, California, United States
|
| 132 |
NCT01368068 |
Terminated |
Investigation of Tibolone and Escitalopram in Perimenopausal Depression |
- Perimenopausal Depression
|
- Drug: Tibolone
- Drug: Escitalopram
- Drug: Natvia
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Montgomery and Asberg Depression Rating Scale
- Short Form-36 Health Survey (SF-36)
- Pittsburgh Sleep Quality Index
- (and 2 more...)
|
2 |
Female |
45 Years to 55 Years (Adult) |
NCT01368068 |
161/11 |
|
July 2012 |
July 2012 |
July 2012 |
June 7, 2011 |
March 31, 2015 |
|
- The Alfred Hospital
Melbourne, Victoria, Australia
|
| 133 |
NCT01107041 |
Completed |
Mobile Phone Sensing and Outreach as Adjuncts to Internet-Based Behavioral Intervention for Depression |
|
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Depression, as assessed the Patient Health Questionnaire-9
- Positive Affect (PANAS - Positive Affect Scale)
- Anxiety (GAD-7)
|
2010 |
All |
19 Years and older (Adult, Senior) |
NCT01107041 |
P20MH090318 STU00021825
P20MH090318 |
|
December 2014 |
February 2016 |
July 2016 |
April 20, 2010 |
March 24, 2017 |
|
- Northwestern University
Chicago, Illinois, United States
|
| 134 |
NCT00018733 |
Completed |
Biological Aspects of Depression and Antidepressant Drugs |
|
- Drug: paroxetine
- Drug: Desipramine
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Masking: Double
- Primary Purpose: Treatment
|
|
|
All |
21 Years to 69 Years (Adult, Senior) |
NCT00018733 |
MHBS-031-99F |
|
September 1996 |
|
December 2001 |
July 5, 2001 |
January 21, 2009 |
|
- South Texas Veterans Health Care System
San Antonio, Texas, United States
|
| 135 |
NCT01899716 |
Completed |
Exercise and Severe Depression: Clinical and Biological Analysis |
|
|
Interventional |
Not Applicable |
- Hospital de Clinicas de Porto Alegre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Depressive symptoms
- Quality of Life
- Brain-Derived Neurotrophic Factor(BDNF)
- (and 2 more...)
|
50 |
All |
18 Years to 60 Years (Adult) |
NCT01899716 |
07-438 |
|
January 2008 |
December 2012 |
December 2012 |
July 15, 2013 |
December 30, 2013 |
|
- Hospital de Clincas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
|
| 136 |
NCT00423969 |
Terminated |
Galantamine Augmentation of Escitalopram for Treatment of Depression |
|
- Drug: Galantamine
- Drug: Escitalopram
|
Interventional |
Phase 4 |
- Indiana University School of Medicine
- Indiana University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single
- Primary Purpose: Treatment
|
- Decrease in depression symptoms measured by Hamilton Depression Rating Scale and Clinical Global Improvement Scale
- Improvement of cognitive measures scores:Selective Reminding Test, Trail Making Test and others
|
20 |
All |
18 Years to 60 Years (Adult) |
NCT00423969 |
0301-35
45-869-96 |
|
November 2003 |
|
September 2005 |
January 18, 2007 |
January 18, 2007 |
|
- IU Adult Psychiatric Clinic
Indianapolis, Indiana, United States
|
| 137 |
NCT02144844 |
Completed |
A Public Health Program to Reduce Risk of Antepartum Depression |
|
- Behavioral: Insight-Plus Cognitive Behavioral Intervention
|
Interventional |
Not Applicable |
- East Carolina University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Mean change in Edinburgh Postpartum Depression Scale (EPDS) Scores from baseline to post intervention and 1-month follow-up
- Mean change in antepartum Beck Depression Inventory (BDI-II) Scores from baseline to post intervention and 1-month follow-up
|
146 |
Female |
18 Years and older (Adult, Senior) |
NCT02144844 |
8045091
1R34MH086680-01A1 |
APD |
December 2010 |
November 2013 |
November 2013 |
May 22, 2014 |
May 22, 2014 |
|
- Brody School of Medicine Regional Perinatal Center
Greenville, North Carolina, United States - Pitt County Health Department
Greenville, North Carolina, United States
|
| 138 |
NCT03167307 |
Recruiting |
The Omega-3 Fatty Acid Paediatric Depression Trial |
|
- Drug: Omega 3 fatty acid
- Drug: Placebo oil
|
Interventional |
Phase 3 |
- Gregor Berger
- Swiss National Science Foundation
- Psychiatric University Hospital, Zurich
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Symptomatic improvement
- Recovery rate
- Remission rate
- (and 13 more...)
|
220 |
All |
8 Years to 18 Years (Child, Adult) |
NCT03167307 |
SNF 33IC30_166826
2016-02116 |
Omega-3-pMDD |
May 2017 |
December 2020 |
December 2020 |
May 25, 2017 |
May 25, 2017 |
|
- Psychiatric University Clinics, Department of Child and Adolescent Psychiatry
Zurich, ZH, Switzerland
|
| 139 |
NCT02328833 |
Unknown † |
Controlled Study About Implementation of a Computerized Depression Guideline in Primary Care |
|
- Other: Experimental strategies of guidelines implementation
|
Interventional |
Not Applicable |
- Corporacion Parc Tauli
- Instituto de Salud Carlos III
- Hospital Clinic of Barcelona
- Institut Catala de Salut
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- The rate of patients in which the instruments from the Computerized Depression Guideline were used.
- Incidence of major depression patients registered in the electronical clinical record.
- Rates of suicide and suicide attempts
- (and 4 more...)
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT02328833 |
SM-CSPT-DP2014-01 |
GPC-DEPc |
January 2015 |
June 2016 |
December 2016 |
December 31, 2014 |
December 31, 2014 |
|
|
| 140 |
NCT03446963 |
Not yet recruiting |
Social Connectedness in Depression |
|
- Behavioral: Groups for Health
|
Interventional |
Not Applicable |
- University of Nottingham
- NIHR CLAHRC East Midlands
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Feasibility of recruitment
- Feasibility of enrollment
- Feasibility of data collection
- Patient retention
|
50 |
All |
18 Years to 65 Years (Adult) |
NCT03446963 |
17110 |
G4H-UK |
March 2018 |
September 30, 2019 |
September 30, 2020 |
February 27, 2018 |
February 27, 2018 |
|
|
| 141 |
NCT00949845 |
Completed |
Cytokine-Associated Depression and Social Pain |
|
|
Interventional |
Early Phase 1 |
- University of California, Los Angeles
|
Other |
- Primary Purpose: Basic Science
|
|
|
All |
18 Years to 45 Years (Adult) |
NCT00949845 |
Endotoxin |
|
January 2007 |
|
|
July 30, 2009 |
July 30, 2009 |
|
- UCLA General Clinical Research Center
Los Angeles, California, United States
|
| 142 |
NCT02901249 |
Completed |
Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder |
|
- Drug: sertraline
- Drug: Nortriptyline
- Drug: Lithium Carbonate
|
Interventional |
Phase 4 |
- Federal University of Rio Grande do Sul
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Response to treatment
- Remission
- Quality of life
|
68 |
All |
18 Years to 65 Years (Adult) |
NCT02901249 |
017/2009 |
|
May 2010 |
November 2014 |
September 2015 |
September 15, 2016 |
September 15, 2016 |
|
|
| 143 |
NCT00709150 |
Completed |
Collaborative Depression Care Management in Treating Depressed Low-income Hispanics With Diabetes |
|
- Behavioral: Collaborative depression care management
- Behavioral: Enhanced usual care
|
Interventional |
Phase 4 |
- University of Southern California
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Reduction in symptoms of major depression
- Quality of life
|
387 |
All |
18 Years and older (Adult, Senior) |
NCT00709150 |
R01MH068468
DSIR 82-SESQ |
MDDP |
March 2005 |
September 2009 |
September 2009 |
July 3, 2008 |
July 29, 2013 |
|
- University of Southern California School of Social Work
Los Angeles, California, United States
|
| 144 |
NCT03109717 |
Recruiting |
Structural and Functional Connectivity of Brainstem Monoamine Pathways in Treatment Resistant Depression |
- Treatment Resistant Depression
|
- Drug: Monoamine Oxidase Inhibitor (MAOI)
|
Observational |
|
- Amit Anand, MD
- The Cleveland Clinic
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Brainstem Structural Connectivity (Sc)
- Brainstem Functional Connectivity (Fc)
|
24 |
All |
18 Years to 65 Years (Adult) |
NCT03109717 |
15-1372 |
MAOI |
July 2016 |
December 2018 |
December 2019 |
April 12, 2017 |
March 30, 2018 |
|
- Cleveland Clinic
Cleveland, Ohio, United States
|
| 145 |
NCT03276793 |
Recruiting |
Brain Connectivity in Depression |
|
- Other: MRI scan
- Behavioral: Behavioral testing
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Prediction of rTMS clinical response
|
60 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03276793 |
BIDMC |
|
March 2018 |
October 31, 2022 |
October 31, 2022 |
September 8, 2017 |
March 5, 2018 |
|
- Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States - Butler Hospital
Providence, Rhode Island, United States
|
| 146 |
NCT00276900 |
Completed |
Sertraline for the Prevention of Recurrent Postpartum Depression |
|
|
Interventional |
Phase 3 |
- University of Pittsburgh
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double
- Primary Purpose: Prevention
|
- Depressive symptoms (measured at Weeks 24 and 52 postpartum)
- Functioning (measured at Weeks 24 and 52 postpartum)
|
300 |
Female |
18 Years to 45 Years (Adult) |
NCT00276900 |
R01MH053735
DSIR 83-ATP |
|
December 2003 |
August 2006 |
August 2006 |
January 13, 2006 |
October 7, 2013 |
|
- Women's Behavioral HealthCare Program
Pittsburgh, Pennsylvania, United States
|
| 147 |
NCT01590784 |
Completed |
Reliability and Validity of Thai Calgary Depression Scale of Schizophrenia (CDSS) |
|
|
Observational |
|
|
Other |
- Time Perspective: Cross-Sectional
|
- The reliability of the Thai version of the Calgary Depression Scale for Schizophrenia (CDSS) in schizophrenia patients.
- The validity of the Thai version of the Calgary Depression Scale for Schizophrenia (CDSS) in schizophrenia patients.
- The prevalence of depression in patients with schizophrenia
- (and 3 more...)
|
60 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT01590784 |
PSY-11-09-09-12 |
|
January 2012 |
June 2014 |
November 2014 |
May 3, 2012 |
July 28, 2016 |
|
- Chiang Mai University
Chiang Mai, Thailand
|
| 148 |
NCT02567110 |
Recruiting |
Magnetic Resonance Spectroscopy (MRS) in Midlife Depression |
- Depression
- Depression Bipolar
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Levels of Glutamate in the basal ganglia
- Neurocognitive Testing
- Depression - Clinician rated
- Disease affecting white matter connecting frontal cortex to other regions of the brain
|
145 |
All |
40 Years to 65 Years (Adult) |
NCT02567110 |
IRB00083464 |
|
July 2016 |
December 2020 |
December 2020 |
October 2, 2015 |
August 24, 2017 |
|
- Emory Clinic
Atlanta, Georgia, United States - Emory University Hospital Clinical Research Network
Atlanta, Georgia, United States - Emory University
Atlanta, Georgia, United States
|
| 149 |
NCT01628783 |
Unknown † |
Sequence Towards Remission in Depression |
|
- Drug: escitalopram 10 mg
- Drug: Placebo
|
Interventional |
Phase 4 |
- Jesper Ekelund
- Academy of Finland
- Helsinki University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Montgomery-Åsberg rating scale
|
90 |
All |
18 Years to 60 Years (Adult) |
NCT01628783 |
2012-002476-14 |
STRIDE |
June 2012 |
December 2014 |
October 2015 |
June 27, 2012 |
June 27, 2012 |
|
- Helsinki University Central Hospital, Psychiatry Centre
Helsinki, Finland
|
| 150 |
NCT02675556 |
Recruiting |
Allogeneic Human Mesenchymal Stem Cells (hMSCs) Infusion in Patients With Treatment Resistant Depression |
- Treatment Resistant Depression
|
- Drug: Allo-hMSCs
- Drug: Placebo
|
Interventional |
Phase 1 |
- Joshua M Hare
- University of Miami
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Incidence of any treatment-emergent serious adverse events (TE-SAEs)
- Reduction of Inflammation
|
88 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02675556 |
20140917 |
ANU |
October 31, 2017 |
March 2024 |
June 2025 |
February 5, 2016 |
January 23, 2018 |
|
- University of Miami Miller School of Medicine
Miami, Florida, United States
|
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