101 |
NCT03112187 |
Recruiting |
FLIPS: Ferfer Liposomal Iron Performance Study |
|
|
Interventional |
Phase 4 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Efficacy of a novel food supplement, Ferfer® to raise the capacity of Haemoglobin levels
- Adverse Event
- Efficacy of a novel food supplement, Ferfer® to raise the capacity of ferritin levels
|
400 |
Female |
18 Years to 40 Years (Adult) |
NCT03112187 |
PE/PK/FLIPS/SP/2017-01 |
FLIPS |
August 1, 2017 |
April 30, 2018 |
July 31, 2018 |
April 13, 2017 |
December 28, 2017 |
|
- Lubna Shahzad,Al-raheem surgical and Maternity Hospital, Daroghwala
Lahore, Sindh, Pakistan
|
102 |
NCT03108508 |
Recruiting |
Non-inferiority Bioavailabilty Study of 3 Silicon-rich Supplements |
|
- Dietary Supplement: Prod1
- Dietary Supplement: Prod2
- Dietary Supplement: Prod3
|
Interventional |
Not Applicable |
- Technological Centre of Nutrition and Health, Spain
- SILICIUM ESPAÑA LABORATORIOS SLU
- Hospital Universitari Sant Joan de Reus
- University Rovira i Virgili
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- concentration of sillicium in urine samples
- concentration of sillicium in plasma
|
5 |
Male |
18 Years and older (Adult, Senior) |
NCT03108508 |
BIOSILICI |
BIOSILICI |
March 15, 2017 |
April 2017 |
April 2017 |
April 11, 2017 |
April 11, 2017 |
|
- Technological Centre of Nutrition and Health (CTNS)
Reus, Tarragona, Spain
|
103 |
NCT03106805 |
Recruiting |
Early Versus Late Interval Postpartum Copper Intrauterine Device Insertion |
|
- Procedure: early insertion
- Procedure: late insertion
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- The number of participants use the device
|
486 |
Female |
20 Years to 40 Years (Adult) |
NCT03106805 |
EAIUD |
|
July 1, 2017 |
May 2019 |
August 2019 |
April 10, 2017 |
August 16, 2017 |
|
- Assiut Faculty of Medicine
Assiut, Egypt
|
104 |
NCT03079583 |
Not yet recruiting |
The Efficacy of Zinc-biofortified Rice in Bangladeshi Children |
- Biofortification
- Zinc Deficiency
- Growth; Stunting, Nutritional
|
- Dietary Supplement: Intervention-group
- Dietary Supplement: Control-group
|
Interventional |
Not Applicable |
- Swiss Federal Institute of Technology
- HarvestPlus
- Brac University, Bangladesh
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- plasma zinc
- inflammatory markers
- zinc biomarkers
- (and 4 more...)
|
470 |
All |
12 Months to 36 Months (Child) |
NCT03079583 |
BAZIRI_1_trail |
BAZIRI |
April 2018 |
December 2018 |
April 2019 |
March 14, 2017 |
March 16, 2018 |
|
- BRACU, Bangladesh
Dhaka, Bangladesh - Swiss Federal Institute of Technology (ETH)
Zurich, Switzerland
|
105 |
NCT03078842 |
Recruiting |
Zinc Dosing Trial - Does Dose Reduction Reduce Side Effects But Retain Efficacy in Diarrhoea Management |
|
- Dietary Supplement: Zinc tablets, 20 mg per day
- Dietary Supplement: Zinc tablets, 10 mg per day
- Dietary Supplement: Zinc tablets, 5 mg per day
|
Interventional |
Not Applicable |
- Per Ashorn
- Center for Public Health Kinetics
- Muhimbili University of Health and Allied Sciences
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Proportion with long duration of diarrhoea
- Continuation of diarrhoea symptoms
- Proportion of children vomiting after zinc treatment
- (and 6 more...)
|
4500 |
All |
6 Months to 59 Months (Child) |
NCT03078842 |
ERC.0002738 |
ZTDT |
January 23, 2017 |
December 31, 2018 |
December 31, 2018 |
March 13, 2017 |
January 26, 2018 |
|
- Centre for Public Health Kinetics
New Delhi, India - Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
|
106 |
NCT03063788 |
Not yet recruiting |
Imaging the HIV Reservoir |
|
|
Interventional |
Phase 1 |
- Bayside Health
- The Peter Doherty Institute for Infection and Immunity
- Monash University
- (and 3 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Comparisons of PET standard uptake values in regions of interest (gastrointestinal tract, lymph node groups, genital tract, and spleen) between the three groups (uninfected, viremic and aviremic infected)
- Safety and tolerability (adverse events and assessment of laboratory parameters)
- Comparisons of PET standard uptake values in regions of interest within each individual to radioactivity levels in a homogenous area of muscle to generate target to muscle ratios.
|
10 |
All |
18 Years to 65 Years (Adult) |
NCT03063788 |
568/16 |
|
February 2018 |
November 2018 |
February 2019 |
February 24, 2017 |
December 28, 2017 |
|
|
107 |
NCT03039413 |
Recruiting |
Copper Cu-64 TP3805 PET/CT in Imaging Patients With Urothelial Cancer Undergoing Surgery or Biopsy |
- Bladder Urothelial Carcinoma
- Urothelial Carcinoma
|
- Drug: Copper Cu 64 TP3805
- Procedure: Positron Emission Tomography
- Procedure: Computed Tomography
|
Interventional |
Early Phase 1 |
- Sidney Kimmel Cancer Center at Thomas Jefferson University
- Thomas Jefferson University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Feasibility of Cu-64-TP3805 to detect UC as determined by post-surgical histology
- Blood clearance defined as the point at which radioactivity decreases to 50% of the initial value
- Radioactivity internalization of copper Cu 64 TP3805 as analyzed in centrifuged urine samples
|
30 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03039413 |
16G.500 |
|
September 28, 2016 |
March 15, 2021 |
January 30, 2022 |
February 1, 2017 |
November 24, 2017 |
|
- Sidney Kimmel Cancer Center at Thomas Jefferson University
Philadelphia, Pennsylvania, United States
|
108 |
NCT03036462 |
Recruiting |
Intravenous Iron in Patients With Systolic Heart Failure and Iron Deficiency to Improve Morbidity & Mortality |
- Systolic Heart Failure
- Iron Deficiency
|
|
Interventional |
Phase 4 |
- Universitätsklinikum Hamburg-Eppendorf
- Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
- University of Göttingen
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Combined rate of recurrent hospitalisations for heart failure (HF) and of cardiovascular death (number of events)
- Combined rate of recurrent cardiovascular hospitalisations and of cardiovascular death (number of events)
- Combined rate of recurrent hospitalisations for any reason and of cardiovascular death (number of events)
- (and 13 more...)
|
1200 |
All |
18 Years and older (Adult, Senior) |
NCT03036462 |
FAIR-HF2 FAIR-HF2-DZHK5 |
FAIR-HF2 |
February 7, 2017 |
October 2020 |
October 2020 |
January 30, 2017 |
December 21, 2017 |
|
- Kerckhoff Klinik Bad Nauheim
Bad Nauheim, Germany - Universitätsmedizin Berlin Campus Benjamin Franklin
Berlin, Germany - Charité Berlin (Campus Virchow-Klinikum)
Berlin, Germany - (and 40 more...)
|
109 |
NCT02999217 |
Recruiting |
Intravenous Iron for Correction of Anaemia After Colorectal Surgery |
- Anemia, Iron-Deficiency
- Intravenous Drug Usage
- Colorectal Neoplasms
- Colorectal Surgery
|
- Drug: Iron isomaltoside
- Drug: Saline
|
Interventional |
Phase 4 |
- Kaunas University of Medicine
- Orivas, Lithuania
- Pharmacosmos A/S
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in haemoglobin level
- Changes of plasma ferritin
- Changes of red blood cell count
- (and 8 more...)
|
100 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02999217 |
BEC-MF-74 |
|
October 2016 |
October 2017 |
October 2018 |
December 21, 2016 |
December 21, 2016 |
|
- Department of Anaesthesiology, Lithuanian University of Health Sciences
Kaunas, Lithuania
|
110 |
NCT02989623 |
Recruiting |
Copper Cu 64 TP3805 PET in Detecting Prostate Cancer in Patients With Persistently Elevated PSA |
|
- Radiation: Copper Cu 64 TP3805
- Procedure: Positron Emission Tomography and Computed Tomography Scan
|
Interventional |
Not Applicable |
- Sidney Kimmel Cancer Center at Thomas Jefferson University
- National Institutes of Health (NIH)
- Thomas Jefferson University
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Prostate cancer detection within the prostate gland by copper Cu 64 TP3805 PET
- Incidence of multiple lesions in an individual patient
|
20 |
Male |
21 Years and older (Adult, Senior) |
NCT02989623 |
15F.264 |
|
September 1, 2015 |
January 2019 |
February 2019 |
December 12, 2016 |
March 16, 2018 |
|
- Thomas Jefferson University
Philadelphia, Pennsylvania, United States
|
111 |
NCT02979249 |
Recruiting |
Oral Iron for Erythropoietic Protoporphyrias |
- Erythropoietic Protoporphyria
- EPP
- X-linked Protoporphyria
- XLP
|
|
Interventional |
Not Applicable |
- Icahn School of Medicine at Mount Sinai
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in erythrocyte protoporphyrin levels
- EPP-specific Quality of Life Questionnaire
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02979249 |
GCO 08-0959-1001 U54DK083909 |
EPP |
December 2016 |
August 2019 |
August 2019 |
December 1, 2016 |
February 2, 2018 |
|
- University of Alabama, Birmingham
Birmingham, Alabama, United States - University of California
San Francisco, California, United States - Icahn School of Medicine at Mount Sinai
New York, New York, United States - (and 3 more...)
|
112 |
NCT02979132 |
Recruiting |
Iron Long-Term Labelling Study Switzerland |
|
- Drug: Eisensulfat LOMAPHARM 50 mg
- Drug: Ferinject(R)
- Dietary Supplement: iron fortified biscuits
|
Interventional |
Not Applicable |
- Prof. Michael B. Zimmermann
- Swiss Federal Institute of Technology
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- iron isotope composition in blood
|
60 |
Female |
18 Years to 50 Years (Adult) |
NCT02979132 |
Fe_LTL_Swi |
|
September 1, 2017 |
July 31, 2018 |
March 31, 2019 |
December 1, 2016 |
November 7, 2017 |
|
- Human Nutrition Laboratory, ETH Zürich
Zürich, Zurich, Switzerland
|
113 |
NCT02973074 |
Recruiting |
Oral Iron Substitution for Orthopedic Surgery |
|
- Dietary Supplement: OLEOvital
|
Interventional |
Not Applicable |
- Kepler University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- increase of hemoglobin level
|
20 |
All |
55 Years and older (Adult, Senior) |
NCT02973074 |
C-124-16 |
|
November 2016 |
November 2017 |
November 2017 |
November 25, 2016 |
November 29, 2016 |
|
- Kepler University Hospital
Linz, Austria
|
114 |
NCT02957643 |
Not yet recruiting |
Substitution of the Normal Levels of Iron and Hemoglobin in Pregnant Women With Iron Supplement |
|
|
Interventional |
Phase 1 Phase 2 |
- Hippocration General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Measured and reported effectiveness of iron in the treatment of iron deficiency in pregnant 2nd and 3rd quarter with questionnaire
|
50 |
Female |
18 Years to 45 Years (Adult) |
NCT02957643 |
HippokratioGH |
|
November 2016 |
September 2017 |
September 2018 |
November 8, 2016 |
November 8, 2016 |
|
|
115 |
NCT02949765 |
Recruiting |
Effects of a Dietary Approach to Iron Deficiency in Premenopausal Women Affected by Celiac Disease |
- Celiac Disease
- Iron Deficiency (Without Anemia)
|
- Drug: Iron sulfate 105 mg
- Dietary Supplement: Iron-rich diet
|
Interventional |
Not Applicable |
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ferritin levels (ng/mL) increase > 95% compared to basal levels
- Hemoglobin levels (g/dL), compared to basal levels
- Iron levels (mcd/dl), compared to basal levels
- Transferrin saturation (%, ratio of serum iron and total iron-binding capacity), compared to basal levels
|
35 |
Female |
18 Years to 50 Years (Adult) |
NCT02949765 |
Atto 302/2016 |
|
December 2015 |
June 2017 |
September 2017 |
October 31, 2016 |
March 14, 2017 |
|
- Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, Italy
|
116 |
NCT02941081 |
Recruiting |
A Novel Nano-iron Supplement to Safely Combat Iron Deficiency and Anaemia in Young Children: a Doubleblind Randomised Controlled Trial |
- Iron Deficiency, Anaemia in Children
|
- Dietary Supplement: IHAT
- Dietary Supplement: Ferrous Sulphate
- Other: Placebo
|
Interventional |
Phase 2 |
- London School of Hygiene and Tropical Medicine
- National Nutrition Agency (NaNa), The Gambia
- Wellcome Trust
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- proportion of children with iron deficiency
- Proportion of children with anaemia
- incidence density' of moderate-severe diarrhea episodes
- (and 13 more...)
|
705 |
All |
6 Months to 35 Months (Child) |
NCT02941081 |
SCC 1489 |
IHAT-Gut |
January 8, 2018 |
November 2018 |
May 2019 |
October 21, 2016 |
March 22, 2018 |
|
- MRC Unit The Gambia
Basse, Upper River Region, Gambia
|
117 |
NCT02933034 |
Recruiting |
Clinical Trial of Manganese-Enhanced MRI (MEMRI) to Assess Peri-Infarct Injury |
|
- Drug: 'SEEMORE' - MANGANESE-ENHANCED MRI CONTRAST REAGENT
|
Interventional |
Phase 1 Phase 2 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Comparison of myocardial infarction size measurements using investigational manganese-enhanced MRI (MEMRI) or delayed gadolinium enhanced MRI (DEMRI), and correlation with long-term outcomes
- Safety and tolerability of manganese contrast reagent
|
70 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02933034 |
28508 |
|
April 2015 |
December 2017 |
|
October 14, 2016 |
December 13, 2016 |
|
- Stanford University School of Medicine
Stanford, California, United States
|
118 |
NCT02916654 |
Recruiting |
Sucrosomial Iron in Patients With Celiac Disease and IDA |
- Celiac Disease
- Iron Deficiency Anemia
|
- Dietary Supplement: sucrosomial iron
- Drug: Sulphate iron
|
Interventional |
Not Applicable |
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
20 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02916654 |
33_2014 |
|
April 2015 |
August 2016 |
December 2017 |
September 27, 2016 |
March 27, 2017 |
|
- Fondazione IRCCS Ca' Granda
Milano, MI, Italy
|
119 |
NCT02896465 |
Recruiting |
Human Milk Oligosaccharides and Childhood Diarrhoea |
|
- Other: Oral rehydration solution
- Other: Zinc
- Other: Human milk oligosaccharides
- Other: Breastfeeding
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Improvement (change) of clinical symptoms of diarrhea
- Stools output
- Weight gain
- (and 6 more...)
|
495 |
All |
6 Months to 2 Years (Child) |
NCT02896465 |
13.26.INF |
|
June 2016 |
August 2019 |
December 2019 |
September 12, 2016 |
January 26, 2018 |
|
- International Center for Diarrheal Disease Research
Dhaka, Bangladesh
|
120 |
NCT02871622 |
Not yet recruiting |
BMX Alpha Registry: a Post-market Registry of the BioMatrix Alpha TM |
- Coronary Artery Disease
- Stable Angina
- Ischemia
- (and 3 more...)
|
- Device: BioMatrix AlphaTM
|
Observational |
|
- Biosensors Europe SA
- European Cardiovascular Research Center
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Major adverse cardiac events (MACE) in the overall population, defined as composite of cardiac death, myocardial infarction (Q-wave and non-Q-wave), or clinically driven target vessel revascularization (TVR).
|
2000 |
All |
Child, Adult, Senior |
NCT02871622 |
16EU01 |
|
September 2016 |
December 2017 |
October 2019 |
August 18, 2016 |
August 18, 2016 |
|
- Craigavon Cardiac Center
Craigavon, United Kingdom
|
121 |
NCT02870634 |
Recruiting |
Phase 1 Dose Escalation and PK Study of Cu(II)ATSM in ALS/MND |
- Amyotrophic Lateral Sclerosis
- Motor Neuron Disease
|
|
Interventional |
Phase 1 |
- Collaborative Medicinal Development Pty Limited
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- recommended phase 2 dose as determined by the number of participants at each dose level with dose limiting toxicities
- Treatment-related change in disease severity by ALS Functional Rating Scale - Revised (ALSFRS-R)
- Treatment-related change in cognitive function by Edinburgh Cognitive and Behavioral Assessment (ECAS) score
- (and 6 more...)
|
50 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02870634 |
CMD-2016-001 |
|
October 2016 |
January 2019 |
April 2019 |
August 17, 2016 |
March 8, 2017 |
|
- Macquarie University
Sydenham, New South Wales, Australia - Calvary Health Care Bethlehem
Caulfield, Victoria, Australia
|
122 |
NCT02864836 |
Not yet recruiting |
Study of Copper Isotope in Head and Neck Cancer |
|
- Procedure: Samples collection
|
Observational |
|
- Lille Catholic University
- Ecole Normale Supérieure de Lyon
|
Other |
- Time Perspective: Prospective
|
- Ratio of the different stable isotopes of copper in the various samples and groups
- Patient survival rate
- mRNA expression level of proteins involved in copper metabolism assessed by Polymerase chain reaction (PCR)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02864836 |
RT-14 |
ISOTOPE |
November 2016 |
November 2018 |
November 2021 |
August 12, 2016 |
August 18, 2016 |
|
- GHICL
Lille, France - ENS Lyon
Lyon, France
|
123 |
NCT02856269 |
Recruiting |
Zinc Supplementation and Cardiovascular Risk in HIV |
|
- Dietary Supplement: Zinc gluconate
|
Interventional |
Not Applicable |
- Grace McComsey
- National Institutes of Health (NIH)
- University Hospitals Cleveland Medical Center
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT02856269 |
02-15-07 |
|
September 2016 |
August 2021 |
August 2021 |
August 4, 2016 |
July 11, 2017 |
|
- University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
|
124 |
NCT02833493 |
Not yet recruiting |
Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload |
- Aplastic Anemia
- Dysmyelopoietic Syndromes
- Iron Overload
|
|
Observational |
|
- Peking Union Medical College Hospital
- Novartis
|
Other / Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- MRI T2*/R2* for liver and heart
|
80 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02833493 |
CICL670AAU05 |
|
September 2016 |
September 2019 |
October 2019 |
July 14, 2016 |
July 14, 2016 |
|
|
125 |
NCT02809274 |
Not yet recruiting |
Incidence of Iron Deficiency in Polycythemia Vera (PV) and Association With Disease Features |
|
|
Observational |
|
- Rambam Health Care Campus
- Meir Medical Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence of iron deficiency in patients with PV
- Association between iron deficiency and other clinical features
- Influence of therapy (phlebotomies, hydroxyurea, other therapies) on iron parameters
- (and 2 more...)
|
200 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT02809274 |
0186-16 CTIL |
|
July 2016 |
July 2018 |
August 2018 |
June 22, 2016 |
June 22, 2016 |
|
- Emek Medical center
Afula, Israel - Soroka medical center
Beer Sheva, Israel - Hillel Yaffe Medical Center
Hadera, Israel - (and 9 more...)
|
126 |
NCT02774057 |
Recruiting |
Trial of Captafer® vs. Oral Iron Sulfate in the Treatment of Iron Deficiency Anemia in Patients With IBD |
- Iron Deficiency Anemia
- Inflammatory Bowel Disease
|
- Drug: Captafer®
- Drug: Iron Sulfate
|
Interventional |
Phase 4 |
- American University of Beirut Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Tolerability to Iron sulfate and Captafer® assessed by the number of patients suffering from treatment related side effects using a Treatment Tolerability Assessment Questionnaire 4 point numerical scale (0,1,2,3).
- Number of patients responding to therapy by measuring the change in the following laboratory measures Hemoglobin, Hematocrit, Iron, Total Iron Binding Capacity, Ferritin, Transferrin Saturation and c-reactive protein.
- Number of patients compliant and adherent to treatment intake assessed by paper logged pill counts conducted at 4 different time points.
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02774057 |
IM.AS1.46 |
|
March 2016 |
July 2017 |
August 2017 |
May 17, 2016 |
January 25, 2017 |
|
- American University of Beirut - Medical Center
Beirut, Lebanon
|
127 |
NCT02760940 |
Not yet recruiting |
Anemia in Inflammatory Bowel Disease |
- Anemia
- Bowel Diseases, Inflammatory
|
- Drug: oral liposomal iron
|
Interventional |
Phase 4 |
- Federal University of Juiz de Fora
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Hemoglobin level improvement
- Improvement of quality of life
- Improvement of fatigue
- (and 2 more...)
|
200 |
All |
18 Years to 65 Years (Adult) |
NCT02760940 |
CAAE:0200.0.200.000-10 |
IBD |
August 2016 |
August 2017 |
August 2018 |
May 4, 2016 |
August 9, 2016 |
|
|
128 |
NCT02759536 |
Recruiting |
In-hospital Neutron Irradiator (IHNI)-Based Boron Neutron Capture Therapy (BNCT) in the Treatment of Malignant Melanoma |
- Melanoma
- Boron Neutron Capture Therapy
|
- Radiation: Boronophenylalanine and IHNI-based BNCT
|
Interventional |
Phase 1 Phase 2 |
- The Third Xiangya Hospital of Central South University
- Beijing Capture Technology Co., Ltd
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percentage of participants showing CR/PR to IHNI-based BNCT
- Percentage of participants with treatment-related adverse events
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02759536 |
XY3-IHNI1307A01 |
|
July 2013 |
December 2018 |
|
May 3, 2016 |
June 7, 2016 |
|
- The Third Xiangya Hospital of Central South University
Changsha, Hunan, China
|
129 |
NCT02747316 |
Recruiting |
Iron Absorption and Transfer to the Fetus During Pregnancy in Normal Weight and Overweight/Obese Women and the Effects on Infants Iron Status |
- Overweight
- Obesity
- Pregnancy
|
- Other: Stable iron isotope 57 (57Fe) labeled iron solution
- Other: Stable iron isotope 58 (58Fe) labeled iron solution
|
Interventional |
Not Applicable |
- Swiss Federal Institute of Technology
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Fractional iron absorption
- iron transfer from the mother to the fetus in cord blood
- Change in plasma ferriting
- (and 8 more...)
|
70 |
Female |
18 Years to 45 Years (Adult) |
NCT02747316 |
PIANO |
PIANO |
January 2016 |
December 2017 |
December 2017 |
April 21, 2016 |
October 13, 2016 |
|
- Human Nutrition Laboratory ETH Zurich
Zurich, Switzerland
|
130 |
NCT02706340 |
Recruiting |
Expulsion of Immediate Postplacental Copper Intrauterine Devices at Six Months: A Prospective Cohort Study |
- Postpartum
- Intrauterine Devices, Copper
|
- Other: No intervention - observational study only
|
Observational |
|
- University of Pennsylvania
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The primary objective is to measure the rate of expulsion of the copper intrauterine device (TCu380A, marketed as ParaGard®) when placed within 10 minutes of placental delivery among women delivering at the University of Pennsylvania.
|
480 |
Female |
18 Years and older (Adult, Senior) |
NCT02706340 |
822078 |
PPIUD |
April 2015 |
December 2018 |
July 2019 |
March 11, 2016 |
October 26, 2017 |
|
- Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
|
131 |
NCT02702115 |
Recruiting |
Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I |
|
|
Interventional |
Phase 1 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of Treatment-Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs)
- Effect of SB-318 on IDUA activity
- Effect of SB-318 on urine glycosaminoglycans (GAG) levels
- AAV2/6 clearance in plasma, saliva, urine, stool, and semen
|
9 |
All |
18 Years and older (Adult, Senior) |
NCT02702115 |
SB-318-1502 |
|
May 24, 2017 |
January 2020 |
January 2022 |
March 8, 2016 |
April 17, 2018 |
|
- UCSF Benioff Children's Hospital Oakland
Oakland, California, United States - University of Florida
Gainesville, Florida, United States - Emory University
Atlanta, Georgia, United States - (and 3 more...)
|
132 |
NCT02679820 |
Recruiting |
PostPlacental IUD Insertion |
|
- Device: Copper T intrauterine device
|
Interventional |
Not Applicable |
- Woman's Health University Hospital, Egypt
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Expulsion rate
- The percentage of females seeking contraception
|
100 |
Female |
20 Years to 45 Years (Adult) |
NCT02679820 |
LA010516 |
|
January 2016 |
June 2018 |
June 2018 |
February 10, 2016 |
February 13, 2018 |
|
- Kasr el aini hospital
Cairo, Egypt
|
133 |
NCT02642562 |
Recruiting |
Intravenous Iron Treatment in Patients With Heart Failure and Iron Deficiency: IRONMAN |
- Heart Failure
- Iron Deficiency
- Left Ventricular Systolic Dysfunction
|
- Drug: Iron (III) isomaltoside 1000
|
Interventional |
Phase 4 |
- University of Glasgow
- NHS Greater Glasgow and Clyde
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- CV mortality or hospitalisation for worsening heart failure (analysis will include first and recurrent hospitalisations)
- CV mortality
- Hospitalisation for worsening heart failure (analysis will include first and recurrent hospitalisations)
- (and 11 more...)
|
1300 |
All |
18 Years and older (Adult, Senior) |
NCT02642562 |
GN15CA190 |
IRONMAN |
August 2016 |
February 2021 |
February 2021 |
December 30, 2015 |
October 24, 2017 |
|
- Aberdeen Royal Infirmary
Aberdeen, United Kingdom - Monklands Hospital
Airdrie, United Kingdom - Antrim Area Hospital
Antrim, United Kingdom - (and 48 more...)
|
134 |
NCT02610920 |
Recruiting |
Sentinel Lymph Node Identification in the Axilla of Women With Breast Cancer Using Ultrasound and Iron Injection |
- Breast Neoplasm
- Carcinoma, Ductal, Breast
- Carcinoma, Intraductal, Noninfiltrating
|
- Procedure: Iron-tracer guided axillary ultrasound and biopsy
- Drug: Iron tracer
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Success rate of core needle biopsy of sentinel lymph node
- Concordance rate of core needle biopsy pathology to sentinel lymph node biopsy pathology
|
20 |
Female |
18 Years and older (Adult, Senior) |
NCT02610920 |
AAAP8967 |
|
December 2015 |
June 2017 |
January 2018 |
November 20, 2015 |
July 29, 2016 |
|
- Columbia University Medical Center
New York, New York, United States
|
135 |
NCT02569593 |
Recruiting |
Evaluation of the Absorption Rate From Different Oral Fe-supplements in Obese Volunteers Pre- and Post-RYGB |
|
- Dietary Supplement: Iron supplements, more specific Ferrodyn and Vista Ferrum
|
Interventional |
Not Applicable |
- Katholieke Universiteit Leuven
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- The absorption rate from different oral Fe-supplements
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT02569593 |
IAS15 s58442 |
|
October 2015 |
December 2017 |
August 2018 |
October 7, 2015 |
May 18, 2017 |
|
- University Hospitals Leuven
Leuven, Belgium
|
136 |
NCT02404012 |
Recruiting |
Iron Supplement to Improve Iron Status Following Bariatric Surgery |
|
- Dietary Supplement: Oral iron supplementation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Iron status
- Anemia assessed by Hemoglobin concentrations
|
64 |
Female |
18 Years to 65 Years (Adult) |
NCT02404012 |
IRB1410015305 |
|
November 2014 |
December 2019 |
December 31, 2022 |
March 31, 2015 |
April 20, 2017 |
|
- Purdue University
West Lafayette, Indiana, United States
|
137 |
NCT02308904 |
Recruiting |
Reproductive Capacity and Iron Burden in Thalassemia |
|
- Other: Blood Draw/Semen Exam
- Other: Retrospective data/Chart Review/Relevant Clinical Results
- Other: Pituitary MRI
|
Interventional |
Not Applicable |
- Children's Hospital & Research Center Oakland
- Novartis Pharmaceuticals
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Laboratory studies for pituitary and gonadal function and for iron level measures
- Retrospective analysis of annual LIC and of type and dose of iron chelation agent in the parallel time period
|
30 |
All |
12 Years and older (Child, Adult, Senior) |
NCT02308904 |
CICL670AUS46T |
Fertility thal |
June 2013 |
June 2018 |
June 2018 |
December 4, 2014 |
July 24, 2017 |
|
- UCSF Benioff Children's Hospital Oakland
Oakland, California, United States
|
138 |
NCT02264860 |
Recruiting |
Researching Alveolar Macrophage Improvements With Supplements in HIV |
|
- Dietary Supplement: Zinc and SAMe
|
Interventional |
Not Applicable |
- Emory University
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Dosage Efficacy
- Change in exhaled breath condensate (EBC) levels of glutathione (GSH)
|
60 |
All |
21 Years and older (Adult, Senior) |
NCT02264860 |
IRB00062730a 1R01HL125042-01 |
RAISe |
October 2014 |
December 2018 |
December 2018 |
October 15, 2014 |
February 1, 2018 |
|
- Ponce De Leon Center
Atlanta, Georgia, United States
|
139 |
NCT02242188 |
Recruiting |
Supplementing Iron and Development in Breastfed Infants (SIDBI Study) |
|
- Drug: Iron
- Dietary Supplement: Placebo
|
Interventional |
Phase 4 |
- Medical University of Warsaw
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Psychomotor development
- Hematological and iron status
- Growth
- (and 2 more...)
|
220 |
All |
16 Weeks to 18 Weeks (Child) |
NCT02242188 |
SIDBI study |
SIDBI |
September 2015 |
January 2019 |
June 2019 |
September 16, 2014 |
February 23, 2017 |
|
- Department of Pediatrics, The Medical University of Warsaw
Warsaw, Poland
|
140 |
NCT02233764 |
Recruiting |
Effect of Iron/Zinc-Biofortified Pearl Millet on Growth and Immunity in Children Aged 12-18 Months in India |
- Iron Deficiency
- Zinc Deficiency
|
- Other: FeZnPM
- Other: CtrlPM
|
Interventional |
Not Applicable |
- Cornell University
- SNDT Women's University
- St. John's Research Institute
- Center for the Study of Social Change
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Iron status
- Physical growth
- Immune function
|
250 |
All |
12 Months to 18 Months (Child) |
NCT02233764 |
IRB #: 1403004556 |
|
October 2016 |
June 2018 |
June 2018 |
September 8, 2014 |
October 6, 2017 |
|
- Centre for the Study of Social Change-Mumbai
Mumbai, Maharashtra, India - St. John's Research Institute
Karnataka, India - S.N.D.T. Women's University
Mumbai, India
|
141 |
NCT02184533 |
Recruiting |
Sodium Selenite and Radiation Therapy in Treating Patients With Metastatic Cancer |
- Adenocarcinoma of the Prostate
- Hormone-resistant Prostate Cancer
- Recurrent Prostate Cancer
- (and 3 more...)
|
- Drug: sodium selenite
- Radiation: radiation therapy
- Other: laboratory biomarker analysis
- (and 2 more...)
|
Interventional |
Phase 1 |
- Susan Knox
- National Cancer Institute (NCI)
- Stanford University
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- MTD defined as the maximum dose at which =< 1 of 3 to 6 subjects in a dose group experience a drug-related dose-limiting toxicity, graded according to National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events version (v)4.0
- Safety and tolerability of the combination using the NCI Common Toxicity Criteria v4.0 grading system for adverse events
- Pharmacokinetic (PK) profile
- (and 3 more...)
|
27 |
All |
18 Years and older (Adult, Senior) |
NCT02184533 |
PROS0047 NCI-2014-01361 30587 P30CA124435 |
|
July 2014 |
June 2018 |
June 2019 |
July 9, 2014 |
April 5, 2018 |
|
- Stanford University, School of Medicine
Stanford, California, United States
|
142 |
NCT02130388 |
Recruiting |
The Impact of Zinc Supplementation on Innate Immunity and Patient Safety in Sepsis |
|
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Toxicity will be monitored clinically for symptoms such as new vomiting or diarrhea and by serum zinc and copper levels.
|
64 |
All |
18 Years and older (Adult, Senior) |
NCT02130388 |
2013H0127 |
|
May 2014 |
March 2018 |
August 2018 |
May 5, 2014 |
November 1, 2017 |
|
- OSU Medical Center
Columbus, Ohio, United States
|
143 |
NCT02025543 |
Recruiting |
Confounder-Corrected Quantitative MRI Biomarker of Hepatic Iron Content |
- Iron Overload
- Hemochromatosis
- Hemosiderosis
|
|
Observational |
|
- University of Wisconsin, Madison
- Johns Hopkins University
- Stanford University
- University of Texas
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Primary Outcome Measure
- Precision Outcome Measure
- Accuracy Outcome Measure
- Robustness Outcome Measure
|
200 |
All |
10 Years to 89 Years (Child, Adult, Senior) |
NCT02025543 |
2013-1174 |
|
December 2013 |
December 2019 |
December 2020 |
January 1, 2014 |
March 14, 2018 |
|
- Stanford University
Palo Alto, California, United States - Johns Hopkins University
Baltimore, Maryland, United States - University of Texas-Southwestern
Dallas, Texas, United States - University of Wisconsin, Madison
Madison, Wisconsin, United States
|
144 |
NCT01959438 |
Recruiting |
Sodium Selenite as a Cytotoxic Agent in Advanced Carcinoma |
- Malignant Tumor
- Treatment Resistant Disorders
- Tumor Progression
|
- Drug: Sodium selenite (Introselen)
- Drug: Sodium selenite
|
Interventional |
Phase 1 Phase 2 |
- Karolinska University Hospital
- Cancerfonden
- Cancer and Allergy Foundation
- (and 2 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Maximal tolerable dose (phase I, ongoing)
- Responses
|
32 |
All |
18 Years and older (Adult, Senior) |
NCT01959438 |
Eu-nr 2006-004076-13 |
SECAR |
February 2007 |
October 2016 |
June 2018 |
October 10, 2013 |
October 10, 2013 |
|
- Onkologkliniken, (Dept of Oncology) Södersjukhuset
Stockholm, Sweden
|
145 |
NCT01953107 |
Recruiting |
Oral Iron vs. Placebo in Newly Diagnosed Gynecologic Oncology Patients Who Are Surgical Candidates. |
- Ovarian Cancer
- Cervical Cancer
- Uterine Cancer
- Anemia
|
- Other: Oral Ferrous Fumarate
- Other: Placebo
|
Interventional |
Phase 4 |
- Sunnybrook Health Sciences Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Supportive Care
|
- Mean Difference in Hemoglobin
- Quality of life
|
200 |
Male |
18 Years and older (Adult, Senior) |
NCT01953107 |
GYNEOCC2 |
|
November 2013 |
January 2017 |
November 2017 |
September 30, 2013 |
April 25, 2017 |
|
- Odette Cancer Centre
Toronto, Ontario, Canada
|
146 |
NCT01912261 |
Recruiting |
Effects of Oral Iron on Postoperative Fatigue Upon Coronary Artery Bypass Graft Patients |
|
- Drug: Placebo
- Drug: Polysaccharide iron complex
|
Interventional |
Phase 3 |
- Nova Scotia Health Authority
- Capital Health, Canada
- Dalhousie University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Fatigue Level
- Quality of Life
- Anemia
- (and 2 more...)
|
300 |
All |
19 Years and older (Adult, Senior) |
NCT01912261 |
TheEffectsofOral Iron052013 |
|
December 2014 |
February 2017 |
May 2017 |
July 31, 2013 |
February 24, 2017 |
|
- Capital Health
Halifax, Nova Scotia, Canada
|
147 |
NCT01829386 |
Recruiting |
Non-Heme Iron Load Quantification in the Brain - MRI of Patients With Stroke |
|
- Other: Non heme iron levels on MRI
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Assessment of iron levels in patients with hemorrhagic stroke
|
10 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT01829386 |
HUM00067651 |
|
January 2013 |
December 2019 |
December 2019 |
April 11, 2013 |
April 28, 2017 |
|
- University of Michigan Hospital
Ann Arbor, Michigan, United States
|
148 |
NCT01481766 |
Recruiting |
Iron Treatment for Young Children With Non-anemic Iron Deficiency |
- Non-anemic Iron Deficiency
|
- Dietary Supplement: Ferrous Sulfate
- Dietary Supplement: Placebo
- Behavioral: Dietary counseling
|
Interventional |
Phase 4 |
- The Hospital for Sick Children
- Canadian Institutes of Health Research (CIHR)
- Mead Johnson Nutrition
- (and 2 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mullen Scales of Early Learning
- Laboratory measures
- Child temperament
- Child growth
|
230 |
All |
12 Months to 40 Months (Child) |
NCT01481766 |
1000027782 |
OptEC |
June 2012 |
June 2018 |
December 2018 |
November 30, 2011 |
May 5, 2017 |
|
- St. Michael's Hospital
Toronto, Ontario, Canada - The Hospital for Sick Children
Toronto, Ontario, Canada
|
149 |
NCT01460810 |
Recruiting |
Safety and Efficacy of Silicone Oil Tamponade for Surgical Attenuation of Radiation Damage in Choroidal Melanoma |
|
- Other: 1000CsK Silicon Oil Tamponade
|
Interventional |
Not Applicable |
- University of Colorado, Denver
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Vision Loss
- Severe Visual Loss
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT01460810 |
11-0366 |
|
July 2011 |
December 2022 |
December 2022 |
October 27, 2011 |
August 31, 2017 |
|
- University of Colorado Eye Center
Aurora, Colorado, United States
|
150 |
NCT01447628 |
Recruiting |
IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients |
- Pulmonary Arterial Hypertension
- Iron Deficiency
|
- Drug: Saline
- Drug: Ferinject or CosmoFer
|
Interventional |
Phase 2 |
- Imperial College London
- Fu Wai Hospital, Beijing, China
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in resting pulmonary vascular resistance (PVR)
- Change in Exercise Capacity - Endurance
- Difference in exercise capacity - Incremental
- (and 8 more...)
|
60 |
All |
16 Years to 75 Years (Child, Adult, Senior) |
NCT01447628 |
CRO1811 |
|
October 2011 |
June 2018 |
December 2018 |
October 6, 2011 |
January 30, 2018 |
|
- Fuwai Hospital
Beijing, China - Justus-Liebig University
Giessen, Germany - Papworth Hospital NHS Foundation Trust
Cambridge, United Kingdom - (and 2 more...)
|