980 studies found for:    Open Studies | "Antineoplastic Agents, Alkylating"
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Rank Status Study
1 Recruiting Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT
Conditions: Acute Myeloid Leukemia;   Acute Lymphoid Leukemia;   Lymphoma;   Myelodysplastic Syndromes;   Chronic Lymphocytic Leukemia;   Immune System Diseases
Interventions: Drug: Cyclophosphamide;   Drug: Busulfan;   Drug: Fludarabine monophosphate;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Procedure: Allogeneic hematopoietic stem cell transplantation
2 Recruiting Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
Condition: Breast Cancer
Interventions: Device: Focused Microwave Thermotherapy;   Drug: Chemotherapy (control)
3 Recruiting Treatment of Resistant Metastatic Melanoma Using Decitabine, Temozolomide and Panobinostat
Condition: Metastatic Melanoma
Intervention: Drug: Temozolomide, Decitabine, Panobinostat
4 Recruiting Efficacy/Safety Study of R-CHOP vs Bortezomib-R-CAP for Young Patients With Diffuse Large B-cell Lymphoma With Poor IPI.
Condition: Diffuse, Large B-Cell, Lymphoma
Interventions: Drug: Bortezomib;   Drug: Rituximab;   Drug: Cyclophosphamide;   Drug: Doxorubicin;   Drug: Prednisone;   Drug: Vincristine
5 Unknown  Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia
Conditions: Waldenström Macroglobulinemia;   Lymphoplasmacytic Lymphoma;   Splenic Marginal Zone Lymphoma
Interventions: Drug: Chlorambucil;   Drug: Fludarabine
6 Recruiting Phase I Study of Romidepsin Plus ICE for Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma
Condition: Lymphoma
Interventions: Drug: Romidepsin;   Drug: Ifosfamide;   Drug: Mesna;   Drug: Carboplatin;   Drug: Etoposide
7 Recruiting Comparative Efficiency of Three Regimen, CEFci, CEF and EC as Neoadjuvant Chemotherapy for Primary Breast Cancer
Condition: Breast Cancer
Interventions: Drug: 5-FU(intravenous infusion)+epirubicin+cyclophosphamide;   Drug: 5-FU(intravenous bolus)+epirubicin+cyclophosphamide;   Drug: epirubicin+cyclophosphamide
8 Unknown  Doxorubicin Hydrochloride Liposome, Melphalan, and Bortezomib in Treating Patients With Relapsed or Refractory Stage I, Stage II, or Stage III Multiple Myeloma
Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: bortezomib;   Drug: melphalan;   Drug: pegylated liposomal doxorubicin hydrochloride
9 Recruiting Adcetris (Brentuximab Vedotin), Combination Chemotherapy, and Radiation Therapy in Treating Younger Patients With Stage IIB, IIIB and IV Hodgkin Lymphoma
Conditions: Stage II Childhood Hodgkin Lymphoma;   Stage III Childhood Hodgkin Lymphoma;   Stage IV Childhood Hodgkin Lymphoma
Interventions: Drug: brentuximab vedotin;   Drug: etoposide;   Drug: prednisone;   Drug: doxorubicin;   Drug: cyclophosphamide;   Drug: Dacarbazine(R);   Drug: filgrastim;   Other: quality of life assessment;   Radiation: radiation therapy
10 Recruiting Lenalidomide and High Dose Melphalan Followed by Autologous Stem Cell Transplant in Multiple Myeloma
Condition: Multiple Myeloma
Interventions: Drug: Lenalidomide plus Melphalan during autologous stem cell transplantation;   Drug: Lenalidomide maintenance
11 Not yet recruiting The Addition of Chloroquine to Chemoradiation for Glioblastoma
Condition: Glioblastoma Multiforme
Interventions: Drug: Chloroquine;   Radiation: Radiotherapy;   Drug: Temozolomide
12 Recruiting A Randomised Evaluation of Molecular Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib
Condition: Lymphoma, Large B-Cell, Diffuse
Interventions: Drug: Rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone;   Drug: Bortezomib, rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone
13 Unknown  Lenalidomide Plus Melphalan as a Preparative Regimen for Autologous Stem Cell Transplantation in Relapsed Multiple Myeloma: A Phase 1 / 2 Study
Condition: Multiple Myeloma
Interventions: Drug: lenalidomide;   Drug: melphalan
14 Recruiting Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies
Conditions: Leukemia, Acute Lymphocytic (ALL);   Leukemia, Myeloid, Acute(AML);   Leukemia, Myeloid, Chronic(CML);   Juvenile Myelomonocytic Leukemia (JMML);   Hemoglobinuria, Paroxysmal Nocturnal (PNH);   Hodgkin Lymphoma;   Lymphoma, Non-Hodgkin (NHL);   Myelodysplastic Syndrome (MDS)
Interventions: Device: CliniMACS;   Procedure: Stem cell transplantation;   Drug: Fludarabine;   Drug: Thioplex®;   Drug: L-phenylalanine mustard;   Drug: Mycophenolate mofetil;   Drug: Rituxan™;   Drug: Alemtuzumab;   Drug: Cyclophosphamide;   Drug: Anti-thymocyte globulin (Rabbit);   Drug: G-CSF
15 Recruiting Tumor Cell Vaccines and ISCOMATRIX With Chemotherapy After Tumor Removal
Conditions: Sarcoma;   Melanoma;   Epithelial Malignancies;   Pleural Malignancy
Interventions: Biological: Epigenetically Modified Autologous Tumor;   Drug: Cyclophosphamide;   Drug: Celecoxib
16 Recruiting T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
Conditions: Metastatic Non-Small Cell Lung Cancer;   Squamous Cell Carcinoma;   Advanced NSCLC;   Adenosquamous Carcinoma;   Adenocarcinomas
Interventions: Drug: Aldesleukin;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Biological: Young TIL
17 Recruiting Autologous Stem Cell Transplantation for Patients With Recurrent Nasopharyngeal Carcinoma
Condition: Recurrent Nasopharynx Carcinoma
Interventions: Drug: Etoposide phosphate;   Drug: Carboplatin;   Drug: Ifosfamide;   Procedure: Autologous Stem Cell Transplantation
18 Recruiting CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII
Conditions: Malignant Glioma;   Glioblastoma;   Brain Cancer
Interventions: Biological: Anti-EGFRvIII CAR transduced PBL;   Drug: Aldesleukin;   Drug: Fludarabine;   Drug: Cyclophosphamide
19 Recruiting Phase II Trial of Neoadjuvant Metronomic Chemotherapy in Triple-Negative Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Doxorubicin / Cyclophosphamide / Paclitaxel / Carboplatin;   Procedure: Definitive Surgery;   Radiation: Radiotherapy
20 Recruiting Dacarbazine and Carmustine in Metastatic Melanoma
Condition: Melanoma Metastatic
Interventions: Drug: Dacarbazine;   Drug: Carmustine;   Drug: Neulasta

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