771 studies found for:    Open Studies | "Antineoplastic Agents, Alkylating"
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Rank Status Study
1 Recruiting Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT
Conditions: Acute Myeloid Leukemia;   Acute Lymphoid Leukemia;   Lymphoma;   Myelodysplastic Syndromes;   Chronic Lymphocytic Leukemia;   Immune System Diseases
Interventions: Drug: Cyclophosphamide;   Drug: Busulfan;   Drug: Fludarabine monophosphate;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Procedure: Allogeneic hematopoietic stem cell transplantation
2 Recruiting Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
Condition: Breast Cancer
Interventions: Device: Focused Microwave Thermotherapy;   Drug: Chemotherapy (control)
3 Recruiting Thiotepa-Clofarabine-Busulfan With Allogeneic Stem Cell Transplant for High Risk Malignancies
Conditions: Stem Cell Transplantation;   Leukemia;   Lymphoma
Interventions: Drug: Thiotepa;   Drug: Clofarabine;   Drug: Busulfan;   Procedure: Allogeneic Stem Cell Transplantation;   Drug: Thymoglobulin (ATG);   Drug: G-CSF (Filgrastim);   Drug: Tacrolimus;   Drug: Methotrexate;   Drug: Cyclophosphamide;   Drug: Mesna
4 Recruiting Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients With Locally Advanced or Recurrent Thymoma or Thymic Carcinoma
Conditions: Thymoma;   Thymic Carcinoma.;   Clinical Masaoka Stage II-IVA
Intervention: Drug: Cetuximab, Cisplatin, Doxorubicin & Cyclophosphamide
5 Recruiting Bevacizumab in Recurrent Grade II and III Glioma
Condition: Brain and Central Nervous System Tumors
Interventions: Biological: Bevacizumab;   Drug: Temozolomide
6 Recruiting INOVATYON STUDY -International, Randomized Study in Patients With Ovarian Cancer
Condition: Ovarian Cancer
Interventions: Drug: Carboplatin;   Drug: Pegylated Lipoxomal Doxorubicin (PLD);   Drug: Trabectedin
7 Recruiting A Trial of Boost Vaccinations of Pancreatic Tumor Cell Vaccine
Condition: Pancreatic Cancer
Intervention: Biological: PANC 10.05 pcDNA-1/GM-Neo and PANC 6.03 pcDNA-1 neo vaccine.
8 Not yet recruiting SGI-110 in Combination With an Allogeneic Colon Cancer Cell Vaccine (GVAX) and Cyclophosphamide (CY) in Metastatic Colorectal Cancer (mCRC)
Condition: Metastatic Colorectal Cancer
Interventions: Drug: CY;   Biological: GVAX;   Drug: SGI-110
9 Recruiting Clinical Study of Metronomic Oral Cyclophosphamide in Patients With Advanced Sarcomas
Condition: Sarcoma
Intervention: Drug: oral cyclophosphamide
10 Recruiting High-dose Cyclophosphamide for Severe Refractory Crohn Disease
Conditions: Crohn's Disease;   Crohn Disease
Intervention: Drug: High-dose Cyclophosphamide
11 Recruiting MT-R Followed by Autologous Stem Cells Transplantation in Newly-diagnosed Primary Central Nervous System Lymphoma
Condition: Primary Central Nervous System Lymphoma
Intervention: Drug: Rituximab plus Methotrexate and Temozolomide followed by autologous stem cell transplantation
12 Recruiting Study of Oprozomib and Dexamethasone, in Combination With Lenalidomide or Oral Cyclophosphamide in Patients With Newly Diagnosed Multiple Myeloma
Condition: Multiple Myeloma
Interventions: Drug: Oprozomib;   Drug: Lenalidomide;   Drug: Dexamethasone;   Drug: Cyclophosphamide
13 Recruiting Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia or Acute Leukemia in Remission
Conditions: Adult Acute Lymphoblastic Leukemia in Remission;   Adult Acute Megakaryoblastic Leukemia (M7);   Adult Acute Minimally Differentiated Myeloid Leukemia (M0);   Adult Acute Monoblastic Leukemia (M5a);   Adult Acute Monocytic Leukemia (M5b);   Adult Acute Myeloblastic Leukemia With Maturation (M2);   Adult Acute Myeloblastic Leukemia Without Maturation (M1);   Adult Acute Myeloid Leukemia in Remission;   Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities;   Adult Acute Myeloid Leukemia With Del(5q);   Adult Acute Myeloid Leukemia With Inv(16)(p13;q22);   Adult Acute Myeloid Leukemia With t(16;16)(p13;q22);   Adult Acute Myeloid Leukemia With t(8;21)(q22;q22);   Adult Acute Myelomonocytic Leukemia (M4);   Adult Erythroleukemia (M6a);   Adult Pure Erythroid Leukemia (M6b);   Previously Treated Myelodysplastic Syndromes;   Secondary Acute Myeloid Leukemia
Interventions: Drug: clofarabine;   Drug: melphalan;   Procedure: allogeneic hematopoietic stem cell transplantation;   Other: laboratory biomarker analysis;   Drug: tacrolimus;   Drug: sirolimus
14 Unknown  Vincristine, Dactinomycin, and Cyclophosphamide in Treating Patients With Embryonal Rhabdomyosarcoma
Condition: Sarcoma
Interventions: Biological: dactinomycin;   Drug: cyclophosphamide;   Drug: vincristine sulfate
15 Recruiting A Multicenter, Open-label, Phase 1b Study of Carfilzomib, Cyclophosphamide and Dexamethasone in Newly Diagnosed Multiple Myeloma Subjects
Condition: Multiple Myeloma
Interventions: Drug: Carfilzomib;   Drug: Cyclophosphamide;   Drug: Dexamethasone
16 Recruiting Shorter Course Tacrolimus After Nonmyeloablative, Related Donor BMT With High-dose Posttransplantation Cyclophosphamide
Conditions: Hodgkin's Lymphoma;   Leukemia;   Myelodysplastic Syndrome(MDS);   Multiple Myeloma;   Non Hodgkin's Lymphoma
Intervention: Procedure: Bone Marrow Transplant
17 Recruiting Consolidation Therapy With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19 in Patients With Chronic Lymphocytic Leukemia Following Upfront Chemotherapy With Pentostatin, Cyclophosphamide and Rituximab
Condition: Leukemia
Interventions: Drug: cyclophosphamide;   Biological: modified T cells
18 Recruiting IPI Biochemotherapy for Chemonaive Patients With Metastatic Melanoma
Condition: Melanoma
Interventions: Drug: Ipilimumab;   Drug: Temozolomide;   Drug: Cisplatin;   Drug: Interferon Alfa-2b;   Drug: Interleukin-2
19 Not yet recruiting Study Assessing the Feasibility of a Surgery and Chemotherapy-Only in Children With Wnt Positive Medulloblastoma
Condition: Medulloblastoma
Interventions: Drug: Lomustine;   Drug: Vincristine;   Drug: Cisplatin;   Drug: Cyclophosphamide;   Drug: Mesna
20 Recruiting A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve CLL or SLL
Conditions: Chronic Lymphocytic Leukemia;   Small-Cell Lymphoma
Interventions: Drug: Ibrutinib;   Drug: Obinutuzumab;   Drug: Chlorambucil

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Indicates status has not been verified in more than two years