997 studies found for:    Open Studies | "Antineoplastic Agents, Alkylating"
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Rank Status Study
1 Recruiting Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT
Conditions: Acute Myeloid Leukemia;   Acute Lymphoid Leukemia;   Lymphoma;   Myelodysplastic Syndromes;   Chronic Lymphocytic Leukemia;   Immune System Diseases
Interventions: Drug: Cyclophosphamide;   Drug: Busulfan;   Drug: Fludarabine monophosphate;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Procedure: Allogeneic hematopoietic stem cell transplantation
2 Recruiting Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
Condition: Breast Cancer
Interventions: Device: Focused Microwave Thermotherapy;   Drug: Chemotherapy (control)
3 Recruiting 3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN
Condition: Neuroblastoma
Interventions: Genetic: iC9-GD2 T Cell Lymphocytes-frozen cells;   Genetic: iC9-GD2 T Cell Lymphocytes-fresh cells;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: pembrolizumab
4 Recruiting Phase 3 Study of Carfilzomib, Melphalan, Prednisone vs Bortezomib, Melphalan, Prednisone in Newly Diagnosed Multiple Myeloma (CLARION)
Condition: Multiple Myeloma
Interventions: Drug: Carfilzomib;   Drug: Bortezomib;   Drug: Melphalan;   Drug: Prednisone
5 Recruiting Bortezomib (Velcade®), Lenalidomide (Revlimid®) and IV Busulfan (Busilvex®) in Patients Under 65 Years Old
Condition: Multiple Myeloma
Interventions: Drug: bortezomib (Velcade ®);   Drug: lenalidomide  (Revlimid®);   Drug: busulfan  (Busilvex ®);   Drug: Dexamethasone acetate;   Drug: Melphalan
6 Recruiting TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL)
Condition: Chronic Lymphocytic Leukemia
Intervention: Drug: TGR-1202 + Obinutuzumab + Chlorambucil
7 Recruiting Rituximab, Bendamustine Hydrochloride, and Bortezomib Followed by Rituximab and Lenalidomide in Treating Older Patients With Previously Untreated Mantle Cell Lymphoma
Conditions: Lymphoma;   Neurotoxicity;   Therapy-related Toxicity
Interventions: Biological: rituximab;   Drug: bendamustine hydrochloride;   Drug: bortezomib;   Drug: lenalidomide
8 Not yet recruiting Phase II Study Temozolomide for Retinoblastoma Metastatic to the Central Nervous System for Patients From Guatemala
Condition: Retinoblastoma
Intervention: Drug: Temozolomide
9 Recruiting Dose Escalation Study of Cyclophosphamide in HIV-Infected Subjects on HAART Receiving SB-728-T
Condition: HIV
Intervention: Genetic: SB-728-T
10 Recruiting Use of Thalidomide, Lenalidomide, Bortezomib and Vorinostat in the Initial Treatment of Newly Diagnosed Multiple Myeloma Patients
Condition: Multiple Myeloma
Interventions: Drug: lenalidomide, cyclophosphamide, dexamethasone;   Drug: thalidomide, cyclophosphamide, dexamethasone;   Drug: bortezomib, cyclophosphamide, dexamethasone;   Drug: lenalidomide maintenance;   Drug: lenalidomide plus vorinostat maintenance
11 Not yet recruiting Neoadjuvant Trial of Capecitabine for Axillary Lymph Node Positive Operable Breast Cancer
Conditions: Stage II Breast Cancer;   Stage III Breast Cancer
Interventions: Drug: fluorouracil;   Drug: capecitabine;   Drug: cyclophosphamide;   Drug: Epirubicin
12 Recruiting Combination Vaccine Immunotherapy (DRibbles) for Patients With Definitively-Treated Stage III Non-small Cell Lung Cancer
Condition: Carcinoma, Non-Small-Cell Lung
Interventions: Drug: Cyclophosphamide;   Biological: DRibble vaccine;   Drug: Imiquimod;   Drug: GM-CSF;   Biological: HPV vaccine
13 Recruiting ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas
Conditions: Lymphoma, Large-Cell, Anaplastic;   Lymphoma, Non-Hodgkin;   Lymphoma, T-Cell
Interventions: Drug: brentuximab vedotin;   Drug: doxorubicin;   Drug: prednisone;   Drug: vincristine;   Drug: cyclophosphamide
14 Not yet recruiting Efficacy of Consolidative Involved-site Radiotherapy for Patients With Limited-stage Follicular Lymphoma
Condition: Follicular Lymphoma
Interventions: Radiation: Consolidation involved-site radiotherapy (ISRT);   Radiation: Consolidation involved-field radiotherapy (IFRT);   Drug: cyclophosphamide;   Drug: doxorubicin;   Drug: vincristine;   Drug: prednisone
15 Recruiting Stem Cell Transplant for Epidermolysis Bullosa
Condition: Epidermolysis Bullosa
Interventions: Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: Anti-thymocyte globulin;   Drug: Cyclosporine A;   Drug: Mycophenolate mofetil;   Procedure: Mesenchymal stem cell  transplantation;   Radiation: Total body irradiation;   Procedure: Umbilical cord blood stem cell transplantation
16 Recruiting Ph II Cabazitaxel/Ifosfamide DD Liposarcoma
Condition: Dedifferentiated Liposarcoma
Interventions: Drug: Cabazitaxel;   Drug: Prolonged infusional ifosfamide
17 Unknown  Methotrexate-based Chemo-immunotherapy Followed by Maintenance Therapy for Patients > 65 Years With Central Nervous System (CNS)-Lymphoma
Condition: Primary Non Hodgkin Lymphoma of the Central Nervous System
Interventions: Drug: Methotrexate;   Drug: Lomustine;   Drug: Procarbazine;   Drug: Rituximab
18 Recruiting Everolimus and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory Hematologic Cancer
Conditions: Recurrent Adult Diffuse Large Cell Lymphoma;   Recurrent Adult Hodgkin Lymphoma;   Recurrent Grade 1 Follicular Lymphoma;   Recurrent Grade 2 Follicular Lymphoma;   Recurrent Grade 3 Follicular Lymphoma;   Recurrent Mantle Cell Lymphoma;   Refractory Chronic Lymphocytic Leukemia;   Multiple Myeloma
Interventions: Drug: everolimus;   Drug: bendamustine hydrochloride
19 Not yet recruiting Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform
Condition: Glioblastoma Multiforme
Interventions: Drug: Temozolomide;   Drug: Disulfiram;   Drug: Copper
20 Recruiting A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma
Condition: Retinoblastoma
Intervention: Drug: Melphalan, Carboplatin

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