999 studies found for:    Open Studies | "Antineoplastic Agents, Alkylating"
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Rank Status Study
1 Recruiting Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT
Conditions: Acute Myeloid Leukemia;   Acute Lymphoid Leukemia;   Lymphoma;   Myelodysplastic Syndromes;   Chronic Lymphocytic Leukemia;   Immune System Diseases
Interventions: Drug: Cyclophosphamide;   Drug: Busulfan;   Drug: Fludarabine monophosphate;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Procedure: Allogeneic hematopoietic stem cell transplantation
2 Recruiting Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
Condition: Breast Cancer
Interventions: Device: Focused Microwave Thermotherapy;   Drug: Chemotherapy (control)
3 Recruiting Study Evaluating the Efficacy of Allogeneic Transplant Conditioning With Adaptive Dose Busulfan Intravenous (Busilvex®) in Patients at High Risk of Carrying Blood Diseases
Condition: Hematological Diseases
Intervention: Drug: Allogeneic transplant conditioning
4 Not yet recruiting Anti-CD20 Radioimmunotherapy Before Chemotherapy and Stem Cell Transplant in Treating Patients With High-Risk B-Cell Malignancies
Conditions: Adult Burkitt Lymphoma;   Adult Diffuse Large B-Cell Lymphoma;   CD20-Positive Neoplastic Cells Present;   Indolent Adult Non-Hodgkin Lymphoma;   Mantle Cell Lymphoma;   Recurrent B-Cell Non-Hodgkin Lymphoma;   Refractory Mature B-Cell Non-Hodgkin Lymphoma
Interventions: Biological: Anti-CD20 B9E9 scFv-Streptavidin Fusion Protein;   Radiation: indium In 111-DOTA-biotin;   Radiation: yttrium Y 90 DOTA-biotin;   Drug: Clearing Agent;   Drug: Carmustine;   Drug: Etoposide;   Drug: Cytarabine;   Drug: Melphalan;   Procedure: Peripheral Blood Stem Cell Transplantation;   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Other: Pharmacological Study;   Other: Laboratory Biomarker Analysis
5 Not yet recruiting TIL Therapy for Metastatic Ovarian Cancer
Condition: Metastatic Ovarian Cancer
Interventions: Drug: Cyclophosphamide;   Drug: Fludarabine;   Biological: TIL infusion;   Drug: Interleukin-2
6 Not yet recruiting Combination Chemotherapy, Rituximab, and Ixazomib Citrate in Treating Patients With Non-Hodgkin Lymphoma
Conditions: Adult Burkitt Lymphoma;   B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma;   Diffuse Large B-Cell Lymphoma;   MYC Gene Mutation;   Plasmablastic Lymphoma
Interventions: Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Ixazomib Citrate;   Other: Laboratory Biomarker Analysis;   Drug: Methotrexate;   Drug: Prednisone;   Biological: Rituximab;   Drug: Therapeutic Hydrocortisone;   Drug: Vincristine Sulfate
7 Recruiting Temozolomide in Patients Affected by Relapsed Sensitive or Refractory Small Cell Lung Cancer With MGMT Methylation
Condition: Small Cell Lung Cancer Recurrent
Intervention: Drug: Temozolomide
8 Not yet recruiting Study of Bendamustine and Ixazomib (MLN9708) Plus Dexamethasone in Relapsed/Refractory Multiple Myeloma
Condition: Multiple Myeloma
Interventions: Drug: MLN9708;   Drug: Dexamethasone;   Drug: Bendamustine
9 Not yet recruiting Study of Obinutuzumab + Chlorambucil, ACP-196 + Obinutuzumab, and ACP-196 in Subjects With Previously Untreated CLL
Condition: Chronic Lymphocytic Leukemia
Interventions: Drug: ACP-196;   Drug: Obinutuzumab;   Drug: Chlorambucil
10 Recruiting Mivacurium Chloramine Muscle Relaxation Effect in Patients With Liver Cirrhosis
Condition: Liver Dysfunction
Intervention: Drug: Mivacurium Chloride
11 Recruiting Study To Examine Toxicity Of Allogeneic Stem Cell Transplantation For Relapsed Or Therapy Refractory Ewings Sarcoma
Condition: EWINGS SARCOMA
Interventions: Drug: Rabbit anti-thymocyte globulin;   Drug: Busulfan;   Drug: Melphalan;   Drug: Fludarabine;   Drug: Cyclophosphamide
12 Not yet recruiting KPT-330 Plus RICE for Relapsed/Refractory Aggressive B-Cell Lymphoma
Conditions: Burkitt's Lymphoma (BL);   B-Cell Lymphoma
Interventions: Drug: KPT-330;   Drug: Rituximab;   Drug: Etoposide;   Drug: Carboplatin;   Drug: Ifosfamide;   Drug: Dexamethasone
13 Recruiting Ruxolitinib in Combination With Autotransplant
Conditions: Myelofibrosis;   MF
Interventions: Drug: RUXOLITINIB / INC 424;   Drug: Filgrastim;   Drug: Busulfan
14 Recruiting Effect of GM1 in Prevention of Taxanes Induced Neurotoxicity in Operable Breast Cancer
Condition: Breast Cancer
Interventions: Drug: EC-T or TC plus GM1;   Drug: EC-T or TC plus placebo
15 Recruiting Pilot Study of Autologous T-cells in Patients With Metastatic Pancreatic Cancer
Condition: Pancreatic Cancer
Interventions: Biological: CART-meso-19 T cells;   Drug: Cyclophosphamide
16 Not yet recruiting Phase II Randomised Trial of Cyclophosphamide and Dexamethasone in Combination With Ixazomib in Relapsed or Refractory Multiple Myeloma.
Condition: Multiple Myeloma
Interventions: Drug: Ixazomib;   Drug: Cyclophosphamide;   Drug: Dexamethasone
17 Not yet recruiting Cyclophosphamide for Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Condition: Idiopathic Pulmonary Fibrosis
Interventions: Drug: Cyclophosphamide;   Drug: Placebo;   Drug: Coticosteroid (prednisolone)
18 Recruiting T Cell Receptor-transduced T Cells Targeting NY-ESO-1 for Treatment of Patients With NY-ESO-1- Expressing Malignancies
Conditions: Bladder Carcinoma;   Breast Cancer;   Esophagus Carcinoma;   Lung Cancer;   Melanoma;   Multiple Myeloma;   Neuroblastoma;   Ovarian Cancer;   Synovial Sarcoma;   Other Metastatic Solid Cancers
Interventions: Drug: Cyclophosphamide;   Drug: Fludarabine;   Biological: Anti-NY ESO-1 TCR-transduced T cells
19 Recruiting A Study to Compare the Efficacy and Safety of Tacrolimus Capsules and Cyclophosphamide Injection in Treatment of Lupus Nephritis
Condition: Lupus Nephritis
Interventions: Drug: Tacrolimus capsules;   Drug: Cyclophosphamide injections;   Drug: Prednisone
20 Recruiting Anti-CD19 Chimeric Antigen Receptor (CAR)-Transduced T Cell Therapy for Patients With B Cell Malignancies
Conditions: Chronic Lymphocytic Leukemia;   Acute Lymphocytic Leukemia;   Lymphoma
Interventions: Drug: Fludarabine;   Drug: Cyclophosphamide;   Biological: Anti-CD19-CAR transduced T cells

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Indicates status has not been verified in more than two years