1009 studies found for:    Open Studies | "Antineoplastic Agents, Alkylating"
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Rank Status Study
1 Recruiting Post-transplantation Cyclophosphamide as GVHD Prophylaxis After HSCT
Conditions: Acute Myeloid Leukemia;   Acute Lymphoid Leukemia;   Lymphoma;   Myelodysplastic Syndromes;   Chronic Lymphocytic Leukemia;   Immune System Diseases
Interventions: Drug: Cyclophosphamide;   Drug: Busulfan;   Drug: Fludarabine monophosphate;   Drug: Tacrolimus;   Drug: Mycophenolate mofetil;   Procedure: Allogeneic hematopoietic stem cell transplantation
2 Recruiting Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
Condition: Breast Cancer
Interventions: Device: Focused Microwave Thermotherapy;   Drug: Chemotherapy (control)
3 Not yet recruiting Neoepitope-based Personalized Vaccine Approach in Patients With Newly Diagnosed Glioblastoma
Conditions: Glioblastoma Multiforme;   Astrocytoma, Grade IV
Interventions: Biological: Personalized peptide vaccine;   Drug: Poly ICLC;   Drug: GM-CSF;   Drug: Temozolomide
4 Not yet recruiting Thiotepa-based Conditioning for Allogeneic Stem-cell Transplantation (SCT) in Lymphoid Malignancies
Conditions: Non Hodgkin Lymphoma;   Hodgkin Lymphoma;   Chronic Lymphocytic Leukemia;   Multiple Myeloma
Intervention: Drug: Thiotepa
5 Not yet recruiting A Phase II Study of NovoTTF-100A Alone and With Temozolomide in Patients With Low-Grade Gliomas
Condition: Glioma
Interventions: Device: NovoTTF-100A;   Drug: Temozolomide
6 Not yet recruiting Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Myeloma
Condition: Multiple Myeloma
Interventions: Drug: Busulfan;   Drug: Palifermin;   Drug: Panobinostat;   Drug: Gemcitabine;   Drug: Melphalan;   Drug: Dexamethasone acetate;   Drug: Caphosol;   Drug: Glutamine;   Drug: Pyridoxine;   Procedure: Stem Cell Transplant
7 Recruiting Neoadjuvant FDC With Melatonin or Metformin for Locally Advanced Breast Cancer.
Condition: Breast Cancer
Interventions: Drug: metformin;   Drug: Fluoruracil;   Drug: Doxorubicin;   Drug: Cyclophosphamide;   Drug: melatonin
8 Not yet recruiting Combination Chemotherapy and Donor Stem Cell Transplant Followed by Ixazomib Citrate Maintenance Therapy in Treating Patients With Relapsed High-Risk Multiple Myeloma
Conditions: Plasma Cell Leukemia;   Recurrent Plasma Cell Myeloma
Interventions: Biological: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Carmustine;   Drug: Cytarabine;   Drug: Etoposide;   Drug: Ixazomib Citrate;   Other: Laboratory Biomarker Analysis;   Drug: Melphalan;   Drug: Methotrexate;   Biological: Peripheral Blood Stem Cell Transplantation;   Other: Quality-of-Life Assessment;   Drug: Tacrolimus
9 Not yet recruiting Multicenter Study of Pharmacokinetic-Guided Docetaxel in Breast Cancer Patients Receiving Docetaxel and Cyclophosphamide
Condition: Breast Cancer
Interventions: Drug: Docetaxel;   Drug: Cyclophosphamide;   Other: Function Assessment of Cancer Therapy (FACT) Surveys
10 Not yet recruiting Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Primary Malignant Brain Tumors
Conditions: Glioblastoma Multiforme;   Glioma;   Gliosarcoma;   Malignant Brain Tumor;   Ependymoma;   Medulloblastoma
Interventions: Drug: Indoximod;   Drug: Temozolomide;   Radiation: Conformal Radiation
11 Recruiting Safety Study of Zinc Finger Nuclease CCR5-modified Hematopoietic Stem/Progenitor Cells in HIV-1 Infected Patients
Condition: HIV
Intervention: Genetic: SB-728mR-HSPC Infusion 3 days following busulfan conditioning
12 Not yet recruiting MK-3475 With Lymphodepletion, TIL and High or Low Dose Interleukin-2 (IL-2)
Condition: Melanoma
Interventions: Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Fludarabine;   Procedure: TIL (T-cells);   Drug: IL-2;   Drug: MK-347;   Behavioral: Questionnaires;   Behavioral: Phone Calls
13 Not yet recruiting A Phase II Study With Bendamustine Plus Brentuximab Vedotin in Hodgkin's Lymphoma and CD30+ Peripheral T-cell Lymphoma in First Salvage Setting: the BBV Regimen
Condition: Lymphatic Diseases
Interventions: Drug: Brentuximab Vedotin;   Drug: Bendamustine
14 Not yet recruiting Nivolumab After Induction Treatment in Triple-negative Breast Cancer (TNBC) Patients
Condition: Breast Cancer
Interventions: Drug: Nivolumab;   Radiation: Radiation therapy;   Drug: Low dose doxorubicin;   Drug: Cyclophosphamide;   Drug: Cisplatin
15 Not yet recruiting Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer
Conditions: High Grade Serous Ovarian Cancer;   Primary Peritoneal Cancer;   Fallopian Tube Cancer
Interventions: Procedure: Production of Genetically-modified T cells;   Drug: Cyclophosphamide;   Device: IP Catheter Insertion;   Genetic: Infusion of 4H11-28z/fIL-12/EFGRt+ Genetically-modified T cells
16 Recruiting Azacytidine Prior to in Vivo T-cell Depleted Allo Stem Cell Transplant for Patients With Myeloid Malignancies in CR
Conditions: Leukemia, Erythroblastic, Acute;   Myelodysplastic Syndromes
Interventions: Drug: 5-Azacytidine;   Drug: Fludarabine;   Drug: Melphalan;   Drug: Alemtuzumab
17 Not yet recruiting Effect of Cytokine-induced Killer Cells for Advanced Malignant Gliomas
Conditions: Cytokine-Induced Killer Cells;   Advanced Milignant Gliomas
Interventions: Drug: Temozolomide;   Biological: CIK
18 Not yet recruiting Effect of Cytokine-induced Killer Cells for Stage I-II Malignant Gliomas
Conditions: Cytokine-Induced Killer Cells;   Milignant Gliomas
Interventions: Drug: Temozolomide;   Biological: CIK
19 Not yet recruiting Hormonal Therapy and Chemotherapy Followed by Prostatectomy in Patients With Prostate Cancer
Condition: Prostate Cancer
Interventions: Drug: Degarelix;   Drug: Doxorubicin;   Drug: Ketoconazole;   Drug: Docetaxel;   Drug: Estramustine
20 Not yet recruiting Efficacy and Safety of Bendamustine Plus Rituximab in Chronic Lympocytic Leukemia
Condition: Chronic Lymphocytic Leukemia
Intervention: Drug: Bendamustine + Rituximab

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Indicates status has not been verified in more than two years