| 1 |
NCT03223350 |
Recruiting |
Topical Capsaicin for Cyclical Vomiting |
|
- Drug: Capsaicin 0.075% Cream
- Drug: Placebos
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Nausea visual analog scale
- Vomiting
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03223350 |
10658 |
|
December 20, 2017 |
November 30, 2018 |
December 31, 2018 |
July 21, 2017 |
December 22, 2017 |
|
- Henry Ford Hospital
Detroit, Michigan, United States
|
| 2 |
NCT03485443 |
Recruiting
New |
Effects of Fluid Infusion on Postoperative Vomiting in Pediatric Patients Undergoing Otorhinolaryngological Surgery |
- Postoperative Nausea and Vomiting
|
- Drug: %0.9 NaCl 10ml/kg
- Drug: %0.9 NaCl 20ml/kg
|
Interventional |
Not Applicable |
- Adnan Menderes University
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Prevention
|
|
150 |
All |
2 Years to 14 Years (Child) |
NCT03485443 |
FLUID-VOMITING |
FLUIDVOMIT |
January 1, 2018 |
June 1, 2018 |
June 1, 2018 |
April 2, 2018 |
April 2, 2018 |
|
- Adnan Menderes University Training and Research Hospital
Aydın, Turkey
|
| 3 |
NCT03185156 |
Recruiting |
The Preventive Effects of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate |
|
- Drug: Propofol
- Drug: Normal saline
|
Interventional |
Not Applicable |
- West China Second University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- The presence of nausea and vomiting
|
60 |
Female |
20 Years to 40 Years (Adult) |
NCT03185156 |
WESTCHINASUHA-023 |
|
June 28, 2017 |
December 30, 2017 |
May 30, 2018 |
June 14, 2017 |
January 26, 2018 |
|
- West China Second University Hospital
Chengdu, Sichuan, China
|
| 4 |
NCT03405324 |
Recruiting |
Effect of tDCS of the Motor Cortex on Chemotherapy Induced Nausia and Vomiting |
- Chemotherapy-induced Nausea and Vomiting
|
- Device: tDCS
- Device: sham tDCS
|
Interventional |
Not Applicable |
- Shereen Mamdouh
- Assiut University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Cumulative of nausea scoring
- cumalative vomiting scoring
|
20 |
Female |
20 Years to 60 Years (Adult) |
NCT03405324 |
233 |
|
January 1, 2018 |
November 2018 |
April 2019 |
January 23, 2018 |
January 23, 2018 |
|
- South Egypt Cancer Institute
Assiut, Egypt
|
| 5 |
NCT03313479 |
Not yet recruiting |
the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting |
- Post Operative Nausea and Vomiting
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
75 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03313479 |
badawy 1 |
|
October 30, 2017 |
November 30, 2017 |
January 1, 2018 |
October 18, 2017 |
October 18, 2017 |
|
- Cairo University
Cairo, Giza, Egypt
|
| 6 |
NCT03434340 |
Not yet recruiting |
Aromatherapy for Prevention of Intrathecal Morphine Induced Nausea and Vomiting |
|
- Biological: Peppermint essential oil
- Drug: Granisetron
- Drug: Dexamethasone
|
Interventional |
Not Applicable |
- Universiti Kebangsaan Malaysia Medical Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Severity of nausea and vomiting
|
156 |
Female |
18 Years to 45 Years (Adult) |
NCT03434340 |
2017461 |
|
June 2018 |
June 2019 |
June 2019 |
February 15, 2018 |
February 15, 2018 |
|
|
| 7 |
NCT01993381 |
Recruiting |
Evaluation of Predictive Risk Factors of Chemotherapy-induced Nausea and Vomiting |
- Chemotherapy-induced Nausea and Vomiting
|
|
Observational |
|
- The Catholic University of Korea
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To evaluate the role of some predictive biomarkers for chemotherapy-induced nausea and vomiting
- To evaluate the clinical characteristics related to chemotherapy-induced nausea and vomiting in Korean patients
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT01993381 |
CINV_CUKorea |
|
November 2013 |
November 2017 |
November 2017 |
November 25, 2013 |
June 14, 2017 |
|
- St. Vincent's Hospital
Suwon, Gyeonggi-do, Korea, Republic of
|
| 8 |
NCT03219710 |
Not yet recruiting |
"Olanzapine for Prevention of Chemotherapy Induced Nausea and Vomiting in Children and Adolescents Receiving Highly Emetogenic Chemotherapy (HEC)" |
- Chemotherapy-induced Nausea and Vomiting
|
- Drug: Ondansetron
- Drug: Dexamethasone
- Drug: Aprepitant
- Drug: Olanzapine
|
Interventional |
Phase 3 |
- All India Institute of Medical Sciences, New Delhi
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- The number of patients with no episodes of vomiting as assessed by CTCAE v4.03 till 120 hours after highly emetogenic chemotherapy.
- The number of patients with no episodes of vomiting as assessed by CTCAE v.03 till 24 hours after highly emetogenic chemotherapy.
- The number of patients with no episodes of vomiting as assessed by CTCAE v4.03after 24 hours till 120 hours post highly emetogenic chemotherapy.
- (and 3 more...)
|
240 |
All |
5 Years to 18 Years (Child, Adult) |
NCT03219710 |
IECPG-151/26.04.2017 |
|
July 2017 |
June 2019 |
June 2019 |
July 17, 2017 |
July 21, 2017 |
|
|
| 9 |
NCT03171688 |
Recruiting |
Risk Factors for Nausea and Vomiting After Cesarean |
- Postoperative Nausea and Vomiting
|
|
Observational |
|
- Brasilia University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Postoperative Nausea or vomiting
|
230 |
Female |
18 Years to 100 Years (Adult, Senior) |
NCT03171688 |
NVPOCesarianasGabriel2017 |
|
May 1, 2016 |
June 1, 2018 |
June 1, 2018 |
May 31, 2017 |
September 13, 2017 |
|
- University Hospital of Brasilia University
Brasilia, Distrito Federal, Brazil
|
| 10 |
NCT03472209 |
Recruiting |
Comparison of Different EtCO2 Levels in Preventing Postoperative Nausea and Vomiting |
- Postoperative Nausea and Vomiting
|
|
Observational |
|
- Karadeniz Technical University
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
60 |
Female |
25 Years to 50 Years (Adult) |
NCT03472209 |
2017/237 |
|
January 22, 2018 |
April 15, 2018 |
June 1, 2018 |
March 21, 2018 |
March 21, 2018 |
|
- Karadeniz Teknik Universitesi
Trabzon, Turkey - Karadeniz Technical University, Dept Obs and Gyn / Anestesiology
Trabzon, Turkey
|
| 11 |
NCT02732379 |
Recruiting |
Effect of Aromatherapy on Postoperative Nausea, Vomiting |
- Postoperative Nausea and Vomiting
|
- Procedure: Lavender Aromatherapy
- Procedure: Rose Aromatherapy
- Procedure: Ginger Aromatherapy
- Procedure: Placebo Aromatherapy
|
Interventional |
Not Applicable |
- Tokat Gaziosmanpasa University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- The change of the nausea scores
- The change of the vomiting score
- The consumption of the antiemetic drug
|
184 |
All |
18 Years to 65 Years (Adult) |
NCT02732379 |
PONV |
|
April 2016 |
April 2018 |
April 2018 |
April 8, 2016 |
February 19, 2018 |
|
- Gaziosmanpasa University Medical School Hospital
Tokat, Turkey
|
| 12 |
NCT03297021 |
Recruiting |
Effects of Ondansetron Dose and Timing on Post-operative Nausea and Vomiting |
- Post-operative Nausea and Vomiting
|
- Drug: Ondansetron 4 MG
- Drug: Ondansetron 8mg
|
Interventional |
Phase 4 |
- Icahn School of Medicine at Mount Sinai
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of Post-operative nausea and vomiting
- Episodes of vomiting in the PACU
- Presence of nausea or vomiting on post-operative day one
- (and 2 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT03297021 |
GCO 17-1618 |
|
October 23, 2017 |
October 2018 |
October 2018 |
September 29, 2017 |
October 31, 2017 |
|
- Icahn School of Medicine at Mount Sinai
New York, New York, United States
|
| 13 |
NCT02966041 |
Recruiting |
Prophylactic Ondansetron in Post-op Cardiac Surgery Patients to Prevent Post-operative Nausea and Vomiting |
- Postoperative Nausea and Vomiting
|
- Drug: Ondansetron
- Drug: Normal Saline/Placebo
|
Interventional |
Not Applicable |
- University of British Columbia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Occurrence of Post-operative Nausea and Vomiting (PONV)
- Frequency of Rescue PONV medication administration
- Time to first dose of rescue PONV medication
- (and 4 more...)
|
180 |
All |
19 Years and older (Adult, Senior) |
NCT02966041 |
H15-00675 |
|
March 6, 2018 |
April 2018 |
April 2018 |
November 17, 2016 |
March 13, 2018 |
|
- St. Paul's Hospital
Vancouver, British Columbia, Canada
|
| 14 |
NCT02666014 |
Recruiting |
Sugammadex Versus Neostigmine for Postoperative Nausea and Vomiting After Laparoscopic Gynaecological Surgery |
- Postoperative Nausea and Vomiting
|
- Drug: Neuromuscular reversal by Sugammadex
- Drug: Neuromuscular reversal by Neostigmine
- Drug: Atropine sulfate-diphenoxylate hydrochloride combination
|
Interventional |
Phase 3 |
- KK Women's and Children's Hospital
- Singhealth Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Incidence of self-reported, postoperative nausea and vomiting (PONV) at 6-hours after neuromuscular blockade reversal with sugammadex or neostigmine, in women at high-risk of PONV, after undergoing laparoscopic gynaecological surgery.
- Incidence of self-reported PONV following administration of Sugammadex or Neostigmine reversal for neuromuscular blockade 24-hours following laparoscopic gynaecological surgery in women at high-risk of PONV.
- Severity of self-reported PONV after administration of Sugammadex or Neostigmine for neuromuscular blockade reversal at 6-hours and 24-hours after undergoing laparoscopic gynaecological surgery in women at high-risk of PONV.
- (and 3 more...)
|
300 |
Female |
21 Years and older (Adult, Senior) |
NCT02666014 |
SHF/FG581S/2013 |
|
June 2015 |
May 2017 |
July 2017 |
January 28, 2016 |
August 31, 2016 |
|
- KK Women's and Children's Hospital
Singapore, Singapore
|
| 15 |
NCT03459248 |
Recruiting |
Metoclopramide-Ondansetron vs. Metoclopramide Therapy for Treatment of Nausea and Vomiting Post Laparoscopic Surgery |
- Postoperative Nausea and Vomiting
|
- Other: Dual therapy
- Other: Monotherapy
- Other: General anesthesia
|
Interventional |
Not Applicable |
- Makassed General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Other
|
- postoperative nausea and vomiting
- Surgeon satisfaction
- Patient satisfaction
|
120 |
All |
16 Years and older (Child, Adult, Senior) |
NCT03459248 |
122018 |
|
February 15, 2018 |
February 2019 |
February 2019 |
March 8, 2018 |
March 19, 2018 |
|
- Makassed General Hospital
Beirut, Lebanon
|
| 16 |
NCT02933099 |
Not yet recruiting |
Aprepitant for the Prevention of Chemotherapy-induced Nausea and Vomiting |
- Chemotherapy-induced Nausea and Vomiting
|
- Drug: Aprepitant+palonosetron+dexamethasone
- Drug: palonosetron+dexamethasone
|
Interventional |
Phase 3 |
- Wuhan Union Hospital, China
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Complete response
- Acute Phase Response
- Delayed Phase Response
- (and 2 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT02933099 |
WuhanUHC |
CINV |
October 2016 |
April 2018 |
December 2018 |
October 14, 2016 |
October 14, 2016 |
|
|
| 17 |
NCT02941913 |
Recruiting |
Compare Between Two Doses of Palonosetron on the Prevention of Postoperative Nausea and Vomiting in Obese Patients |
- Postoperative Nausea and Vomiting
|
|
Interventional |
Phase 4 |
- Instituto Nacional de Cancer, Brazil
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- episodes of nausea and vomiting
- number of patients who need antiemetic rescue medication
- complete antiemetic response
- polymorphism of the 5-HT3 receptors
|
80 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT02941913 |
55695816.7.0000.5274 |
|
October 2016 |
February 2018 |
October 2018 |
October 21, 2016 |
August 29, 2017 |
|
- National Cancer Institute (INCA - HCIII)
Rio de Janeiro, Brazil
|
| 18 |
NCT02457195 |
Recruiting |
Granisetron Transdermal Patch for Prevention of Postoperative Nausea and Vomiting |
- Postoperative Nausea and Vomiting
|
|
Interventional |
Phase 2 |
- Milton S. Hershey Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effectiveness of prophylactic activity in prevention of PONV
|
60 |
All |
18 Years to 89 Years (Adult, Senior) |
NCT02457195 |
HRP-592 |
GTPPONV |
February 2016 |
February 2018 |
February 2018 |
May 29, 2015 |
September 15, 2017 |
|
- Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
|
| 19 |
NCT03165123 |
Not yet recruiting |
Effect of Using Erythromycin A Versus Placebo With Dexamethasone in Prevention of Post-spinal Nausea and Vomiting. |
- Post-operative Nausea and Vomiting
|
- Drug: Oral Erythromycin A tablet
- Drug: Intravenous dexamethasone
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Direct questionnaire of the patients about their nausea and/or vomiting
|
160 |
All |
18 Years to 38 Years (Adult) |
NCT03165123 |
ABCD |
|
June 1, 2017 |
June 1, 2020 |
December 1, 2020 |
May 24, 2017 |
May 25, 2017 |
|
|
| 20 |
NCT03204279 |
Recruiting |
PK/PD Study of Netupitant and Palonosetron in Pediatric Patients for Prevention of Chemotherapy-induced Nausea and Vomiting |
- Chemotherapy-induced Nausea and Vomiting (CINV)
|
- Drug: Netupitant
- Drug: Palonosetron
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Area Under the plasma Concentration versus time curve from time zero to infinity (AUC) of netupitant
- Maximum plasma concentration (Cmax) of netupitant
- Proportion of pediatric patients with complete response during the delayed phase
- Exposure - Response analysis for netupitant
|
92 |
All |
up to 17 Years (Child) |
NCT03204279 |
NEPA-15-31 |
CINV |
August 31, 2017 |
April 2018 |
April 2018 |
July 2, 2017 |
September 21, 2017 |
|
- Nemours/A.I. duPont Hospital for Children
Wilmington, Delaware, United States - Nemours Children's Clinic
Jacksonville, Florida, United States - Nemours Children's Hospital - Orlando
Orlando, Florida, United States - (and 13 more...)
|
| 21 |
NCT03104023 |
Recruiting |
Staple Line Inversion vs Buttressing on Postoperative Vomits After LSG |
|
- Procedure: Staple line inversion
- Combination Product: Staple line buttressing
|
Interventional |
Phase 3 |
- Hospital General Universitario Elche
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Postoperative nausea and vomits
|
100 |
All |
Child, Adult, Senior |
NCT03104023 |
HGUE 2016-33 |
|
January 2017 |
August 2017 |
August 2017 |
April 7, 2017 |
June 27, 2017 |
|
- Hospital general Universitario de Elche
Elche, Alicante, Spain
|
| 22 |
NCT03178058 |
Recruiting |
Risk Factors for Postoperative Nausea, Vomiting and Pruritus |
- Postoperative Nausea and Vomiting
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Demographic causative factors for postoperative nausea after administration of neuraxial morphine
- Demographic causative factors for postoperative vomiting after administration of neuraxial morphine
- Demographic causative factors for postoperative pruritus after administration of neuraxial morphine
|
100 |
Female |
18 Years and older (Adult, Senior) |
NCT03178058 |
0387-15 |
|
October 2016 |
October 2017 |
December 2017 |
June 6, 2017 |
June 6, 2017 |
|
- Beilinson hospital
Petach tikvah, Israel
|
| 23 |
NCT02872935 |
Recruiting |
Minimizing Nausea and Vomiting During Spinals for CS |
|
- Drug: Glycopyrrolate
- Drug: Normal Saline
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Nausea will be measured using a Likert scale ranging from 1 no nausea to 10 the worst nausea Finally reduction in the severity of nausea in the treatment group will be assessed.
- Vomiting will be assessed as yes /no. Finally a reduction in vomiting will be assessed in the treatment group.
- The lowest blood pressure during the time intervals that the nausea is recorded
- The heart rate during the lowest blood pressure recorded.
|
100 |
Female |
18 Years to 45 Years (Adult) |
NCT02872935 |
201301793 |
|
May 15, 2015 |
December 31, 2018 |
December 31, 2018 |
August 19, 2016 |
October 31, 2017 |
|
- University of Iowa
Iowa City, Iowa, United States
|
| 24 |
NCT02767791 |
Recruiting |
Auriculotherapy and Acupuncture's Treatment for Chemotherapy-induced Nausea and Vomiting (CINV) |
|
- Other: Acupuncture
- Other: Auriculotherapy
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
144 |
All |
18 Years and older (Adult, Senior) |
NCT02767791 |
2015/34
2015-A01988-41 |
NVCI |
April 2016 |
May 2018 |
May 2018 |
May 10, 2016 |
November 3, 2016 |
|
- Centre hopsitalier Emmanuel Rain
Gonesse, France - Hôpital René Huguenin
Saint-Cloud, France - Centre spécilaisé en cancérologie Paris Nord
Sarcelles, France - Hopital Foch
Suresnes, France
|
| 25 |
NCT02456662 |
Recruiting |
Scheduled Prophylactic Antiemetics for Reduction of Emesis With Doxycycline (SPARED) Trial |
- Drug-induced Nausea and Vomiting
|
- Drug: Ondansetron
- Drug: Placebo
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Nausea and vomiting after doxycycline use
|
300 |
Female |
18 Years to 45 Years (Adult) |
NCT02456662 |
RSRB00056271 |
SPARED |
October 2015 |
October 2018 |
October 2018 |
May 28, 2015 |
September 26, 2017 |
|
- Lattimore Women's Health Practice
Rochester, New York, United States
|
| 26 |
NCT00550251 |
Recruiting |
Does Acupressure Help Reduce Nausea and Vomiting in Palliative Care Patients? Formal Study |
|
- Device: Acupressure Wrist Bands (Sea-Bands)
- Device: Placebo wristbands
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of PRN Doses of anti-emetics needed
- Visual Analogue Scale of nausea; duration of perceived nausea; number of vomits per 24 hours; volume of vomit per 24 hours; adverse effects of acupressure; measure of whether the patient felt the intervention helped.
|
58 |
All |
18 Years and older (Adult, Senior) |
NCT00550251 |
SRC2 |
|
July 2010 |
September 2017 |
September 2017 |
October 29, 2007 |
May 11, 2017 |
|
- Sue Ryder Care Leckhampton Court Hospice
Cheltenham, Gloucestershire, United Kingdom
|
| 27 |
NCT00727974 |
Recruiting |
Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines |
|
|
Observational |
|
- Medical College of Wisconsin
- Children's Hospital and Health System Foundation, Wisconsin
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Identify novel genes that contribute to the risk of CVS using genomewide association analysis approach.
- Perform genotype-phenotype correlations between genetic profiles and various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine)
|
880 |
All |
up to 21 Years (Child, Adult) |
NCT00727974 |
08/24
GC 607 |
|
January 2008 |
December 2019 |
December 2019 |
August 5, 2008 |
March 23, 2018 |
|
- Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States
|
| 28 |
NCT03202459 |
Recruiting |
Prophylaxy of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery |
- Postoperative Complications
- Postoperative Nausea and Vomiting
|
- Drug: Group A - gabapentin 600 mg
- Drug: Group B - pregabalin
- Drug: Group C - placebo
|
Interventional |
Not Applicable |
- Faculdade de Ciências Médicas da Santa Casa de São Paulo
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Postoperative Nausea or vomiting M0
- Postoperative Nausea or vomiting M12
- Postoperative Nausea or vomiting M24
- (and 9 more...)
|
60 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03202459 |
56057116.0.0000.5479 |
|
March 2, 2017 |
September 30, 2017 |
January 31, 2018 |
June 28, 2017 |
June 28, 2017 |
|
- Irmandade da Santa Casa de Misericórdia de São Paulo
São Paulo, Brazil
|
| 29 |
NCT03434652 |
Recruiting |
Auricular Neurostimulation for Cyclic Vomiting Syndrome |
- Cyclic Vomiting Syndrome
- Abdominal Migraine
|
- Device: Percutaneous neurostimulation
|
Interventional |
Not Applicable |
- Medical College of Wisconsin
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Nausea and vomiting
- Pain
- Anxiety
- (and 4 more...)
|
50 |
All |
10 Years to 65 Years (Child, Adult) |
NCT03434652 |
1102505-4 |
|
January 31, 2018 |
June 30, 2019 |
December 31, 2019 |
February 15, 2018 |
February 16, 2018 |
|
- Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States
|
| 30 |
NCT02755116 |
Recruiting |
Olanzapine for Nausea After Surgery |
- Postoperative Nausea and Vomiting
|
- Drug: Olanzapine
- Drug: Placebo
|
Interventional |
Phase 2 |
- Jaime B Hyman
- Icahn School of Medicine at Mount Sinai
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of Nausea
- Incidence of Vomiting
|
140 |
Female |
18 Years to 50 Years (Adult) |
NCT02755116 |
GCO 15-1297 |
|
January 2016 |
December 2020 |
December 2020 |
April 28, 2016 |
March 22, 2018 |
|
- Icahn School of Medicine at Mount Sinai
New York, New York, United States
|
| 31 |
NCT02473042 |
Recruiting |
Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV) |
- Post-Operative Nausea and Vomiting
- Breast Cancer
|
- Procedure: Electrical Stimulation
- Drug: Zofran
- Drug: Dexamethasone
- (and 3 more...)
|
Interventional |
Not Applicable |
- M.D. Anderson Cancer Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Supportive Care
|
- Efficacy of Electrical Stimulation of P6 Combined with Prophylactic Anti-Emetics Versus Pharmacological Prophylaxis Alone in Preventing the Incidence of Post-Operative Nausea and Vomiting (PONV)
- Feasibility of Intraoperative Neuromuscular Blockade Monitor (NMBM) During Surgery for Breast Cancer
|
176 |
Female |
18 Years and older (Adult, Senior) |
NCT02473042 |
2015-0170
NCI-2015-01519 |
|
February 2016 |
February 2020 |
February 2021 |
June 16, 2015 |
March 20, 2018 |
|
- University of Texas MD Anderson Cancer Center
Houston, Texas, United States
|
| 32 |
NCT03017391 |
Not yet recruiting |
Treatment Algorithm for Nausea and Vomiting in the Palliative Phase |
|
- Drug: metoclopramide
- Drug: granisetron
- Drug: Dexamethasone
- Drug: Granisetron 2Mg Tablet
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- NRS nausea
- days from T0 to control
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03017391 |
CVS01 |
|
January 2017 |
April 2018 |
|
January 11, 2017 |
January 11, 2017 |
|
|
| 33 |
NCT02909478 |
Not yet recruiting |
Aprepitant Without Steroid in Preventing Chemotherapy-induced Nausea and Vomiting in Patients With Colorectal Cancer |
- Chemotherapy-induced Nausea and Vomiting
- Colorectal Cancer
|
- Drug: Aprepitant+Tropisetron
- Drug: Dexamethasone+Tropisetron
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Complete response
- Nausea score
- Time to First Vomiting Episode or Use of Rescue Medication
- (and 2 more...)
|
298 |
All |
18 Years and older (Adult, Senior) |
NCT02909478 |
GIHSYSU12 |
|
December 2016 |
December 2017 |
|
September 21, 2016 |
September 21, 2016 |
|
|
| 34 |
NCT03380182 |
Recruiting |
Acupuncture and Acupressure for Postoperative Nausea and Vomiting in Children Undergoing Outpatient Middle Ear Surgery |
|
- Other: Acupressure Band
- Other: Sham Band
|
Interventional |
Not Applicable |
- University of California, Davis
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- The evaluation of post operative nausea and vomiting at different time points during and after hospital stay.
- number of antiemetics administered during the study period,
- time to oral intake tolerance
- (and 2 more...)
|
80 |
All |
2 Years to 18 Years (Child, Adult) |
NCT03380182 |
987983 |
|
April 5, 2017 |
April 1, 2018 |
April 1, 2018 |
December 21, 2017 |
December 21, 2017 |
|
- University of California Davis Medical Center
Sacramento, California, United States
|
| 35 |
NCT02803788 |
Recruiting |
Post-operative Nausea Vomiting in Laparoscopic Cholecystectomy |
- Postoperative Nausea and Vomiting
|
- Drug: ramosetron, ondansetron, dexamethasone
|
Interventional |
Phase 4 |
- Government Medical College, Haldwani
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Comparison of antiemetic effect of Ramosetron with combination of Ondansetron and Dexamethasone in patients undergoing laparoscopic cholecystectomy
|
100 |
Female |
20 Years to 40 Years (Adult) |
NCT02803788 |
202/GMC/IEC/04/2014 |
PONV |
July 2015 |
July 2016 |
July 2016 |
June 17, 2016 |
June 17, 2016 |
|
- GMC Haldwani
Haldwani, Uttarakhand, India, India
|
| 36 |
NCT03008213 |
Not yet recruiting |
Combination of Netupitant and Palonosetron (Akynzeo®) in the Treatment of Refractory CINV |
- Chemotherapy Induced Nausea Vomiting
|
- Drug: Netupitant and Palonosetron
|
Interventional |
Phase 2 |
- University of California, San Diego
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Number of participants completed all study procedures over seven days
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT03008213 |
UCSD |
CINV |
January 2017 |
December 2019 |
June 2020 |
January 2, 2017 |
January 2, 2017 |
|
|
| 37 |
NCT03483350 |
Not yet recruiting
New |
Comp Granisetron Midazolam Comb in Lap Children |
- Postoperative Nausea and Vomiting
|
- Drug: Granisetron
- Drug: Midazolam
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Vomiting score
- Nausea score
|
90 |
All |
4 Years to 12 Years (Child) |
NCT03483350 |
Gmpl |
|
March 2018 |
August 2018 |
January 2019 |
March 30, 2018 |
March 30, 2018 |
|
|
| 38 |
NCT03478605 |
Recruiting |
Trial to Evaluate Efficacy of Olanzapine With Short-acting 5HT3 Inhibitors in Chemotherapy-induced Nausea & Vomiting (CINV) Prophylaxis |
- Emesis
- Vomiting
- Nausea Post Chemotherapy
- (and 2 more...)
|
- Drug: Olanzapine
- Drug: Aprepitant Pill
- Drug: Ondansetron
- Drug: Dexamethasone
|
Interventional |
Phase 2 |
- Blokhin's Russian Cancer Research Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Nausea control
- Complete Response Rate in Overall Treatment Period
- Rate of undesired sedation
- (and 2 more...)
|
130 |
All |
18 Years and older (Adult, Senior) |
NCT03478605 |
OlaCINV |
OlaCINV |
March 14, 2018 |
March 14, 2019 |
June 1, 2019 |
March 27, 2018 |
March 27, 2018 |
|
- N.N. Blokhin Cancer Research Center
Moscow, Russian Federation
|
| 39 |
NCT03040726 |
Recruiting |
Netupitant and Palonosetron (AKYNZEO) for Chronic Nausea and Vomiting in Cancer Patients |
- In Situ Neoplasm
- Malignant Neoplasms
- Nausea and Vomiting, Chronic
|
- Drug: Netupitant / Palonosetron
- Other: Placebo
- Behavioral: Symptom Questionnaires
- Behavioral: Patient Diary
|
Interventional |
Phase 2
Phase 3 |
- M.D. Anderson Cancer Center
- Helsinn Healthcare SA
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Supportive Care
|
- Change in Nausea Numeric Rating Scale [NRS] of Fixed Dose Netupitant and Palonosetron (NEPA) for Chronic Nausea in Cancer Patients
- Personalized Nausea Response of Fixed Dose Netupitant and Palonosetron (NEPA) for Chronic Nausea in Cancer Patients
|
42 |
All |
18 Years and older (Adult, Senior) |
NCT03040726 |
2016-0843
NCI-2017-00599 |
|
May 3, 2017 |
May 2019 |
May 2019 |
February 2, 2017 |
January 17, 2018 |
|
- University of Texas MD Anderson Cancer Center
Houston, Texas, United States
|
| 40 |
NCT03403712 |
Recruiting |
A Study to Assess the Safety and the Efficacy of IV Fosnetupitant/Palonosetron (260 mg/0.25 mg) Combination Compared to Oral Netupitant/Palonosetron (300 mg/0.5 mg) Combination for the Prevention of CINV in AC Chemotherapy in Women With Breast Cancer |
- Chemotherapy-induced Nausea and Vomiting
|
- Drug: fosnetupitant/ palonosetron
- Drug: netupitant/palonosetron
- Drug: dexamethasone
|
Interventional |
Phase 3 |
- Helsinn Healthcare SA
- George Clinical Pty Ltd
- PSI CRO AG
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- treatment-emergent AEs at cycle 1
- treatment-emergent AEs at cycle 2
- treatment-emergent AEs at cycle 3
- (and 5 more...)
|
400 |
Female |
18 Years and older (Adult, Senior) |
NCT03403712 |
NEPA-17-05 |
|
March 16, 2018 |
October 2018 |
October 2018 |
January 19, 2018 |
April 12, 2018 |
|
- The Oncology Inst. Of Hope and Innovation
Tucson, Arizona, United States - Carti Cancer Center
Little Rock, Arkansas, United States - Pacific Cancer Medical Center, Inc.
Anaheim, California, United States - (and 12 more...)
|
| 41 |
NCT02977741 |
Recruiting |
Olanzapine for the Treatment of Refractory Chronic Nausea and Vomiting |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Nausea and vomiting severity
- Severity of upper gastrointestinal symptoms
- Quality of life and functional status
- (and 2 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT02977741 |
IRB00037144 |
|
November 2016 |
December 2017 |
December 2018 |
November 30, 2016 |
January 20, 2017 |
|
- Johns Hopkins University
Baltimore, Maryland, United States
|
| 42 |
NCT03435003 |
Recruiting |
Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy |
- Post-operative Nausea and Vomiting
- Laparoscopic Sleeve Gastrectomy
|
- Drug: Aprepitant 80Mg Oral Capsule
- Drug: scopolamine transdermal
- Procedure: Total intravenous anesthesia
- (and 10 more...)
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Incidence of PONV-related delay of hospital discharge
- Severity of PONV measured using a visual analogue scale
- Severity of PONV measured using the Rhodes Index
- (and 3 more...)
|
82 |
All |
18 Years and older (Adult, Senior) |
NCT03435003 |
1074296-3 |
|
August 28, 2017 |
August 20, 2018 |
August 20, 2018 |
February 15, 2018 |
February 15, 2018 |
|
- Stony Brook University Hospital
Stony Brook, New York, United States
|
| 43 |
NCT03354741 |
Not yet recruiting |
Stimulation of Acupuncture Points by Athermic Laser Therapy for the Prevention of Chemotherapy Induced Nausea and Vomiting in Children |
- Children
- Chemotherapy-induced Nausea and Vomiting
- Malignant Tumor
|
|
Interventional |
Not Applicable |
- Centre Hospitalier Universitaire de Nice
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- The complete response to the preventive treatment of nausea and vomiting
|
30 |
All |
2 Years to 20 Years (Child, Adult) |
NCT03354741 |
17-AOI-06 |
NAUVOLA |
December 2017 |
January 2018 |
January 2020 |
November 28, 2017 |
November 28, 2017 |
|
- Dr Marilyne POIREE
Nice, France
|
| 44 |
NCT02939287 |
Not yet recruiting |
Aprepitant Versus Olanzapine With High Dose Melphalan |
|
- Drug: Aprepitant
- Drug: Olanzapine
|
Interventional |
Phase 3 |
- Rush University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- complete response (CR)
- Acute complete response
- Delayed complete response
- (and 4 more...)
|
370 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02939287 |
14102001 |
|
November 2016 |
November 2018 |
November 2018 |
October 20, 2016 |
October 20, 2016 |
|
|
| 45 |
NCT02608931 |
Recruiting |
The Safety, Tolerability and Efficacy of Dronabinol, for the Treatment of Nausea and Vomiting in Familial Dysautonomia |
- Nausea
- Vomiting
- Familial Dysautonomia
|
- Drug: Dronabinol
- Other: Placebo
|
Interventional |
Phase 2 |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Number of adverse effects
- Change in nausea scores
- Change in weight.
- Change in anxiety scores
|
25 |
All |
18 Years to 60 Years (Adult) |
NCT02608931 |
14-01577 |
|
November 2015 |
March 2018 |
March 2018 |
November 20, 2015 |
November 22, 2017 |
|
- NYU Medical Center
New York, New York, United States
|
| 46 |
NCT03260426 |
Recruiting |
Trial of Low Residue Diet Versus Clear Liquids Following Elective Colorectal Surgery |
|
- Dietary Supplement: Clear Liquids
- Dietary Supplement: Regular Solid
- Device: Abstats
|
Interventional |
Not Applicable |
- Cedars-Sinai Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patient tolerability, of a regular diet
- Consumption of Diet
- Flatus
- (and 8 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03260426 |
Pro00048403 |
|
August 16, 2017 |
July 31, 2018 |
December 31, 2019 |
August 24, 2017 |
August 31, 2017 |
|
- Cedars Sinai Medical Center
Los Angeles, California, United States
|
| 47 |
NCT02223377 |
Recruiting |
Satisfactory Analgesia Minimal Emesis in Day Surgeries |
- Pain
- Post Operative Nausea and Vomiting
|
- Drug: Morphine
- Drug: Hydromorphone
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Our combined primary outcome will be proportion of patients with Same Analgesia Minimal Emesis, as compared between the 2 groups.
- Severe itching
- Severe sedation
- (and 6 more...)
|
400 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02223377 |
14-482
CAS-2014-038 |
SAME-Day |
January 2015 |
August 2018 |
August 2018 |
August 22, 2014 |
February 16, 2018 |
|
- Hamilton Health Sciences
Hamilton, Ontario, Canada - St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada
|
| 48 |
NCT03061396 |
Recruiting |
The Comparative Study on the Efficacy and Safety of Single Acupoint and Matching Acupoints |
- Electro-acupuncture
- Chemotherapy-induced Nausea and Vomiting
|
- Other: Matching points PC6+CV12
- Other: Single points PC6
|
Interventional |
Not Applicable |
- Tianjin University of Traditional Chinese Medicine
- National Basic Research Program, China
- West China Hospital
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Complete Control rates of Nausea and Vomiting
- Complete Response rates of Vomiting
- Nausea and Vomiting visual analogic scale (VAS)
- (and 5 more...)
|
208 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03061396 |
2014CB543201-03 |
|
February 17, 2017 |
April 28, 2018 |
May 28, 2018 |
February 23, 2017 |
February 9, 2018 |
|
- Tianjin University of TCM
Tianjin, Tianjin, China
|
| 49 |
NCT03313193 |
Recruiting |
Acupressure for Children in Treatment for a Childhood Cancer |
|
- Other: Acupressure for Children in Treatment for a Childhood Cancer
|
Interventional |
Not Applicable |
- University of California, San Francisco
- Patient-Centered Outcomes Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Decrease in nausea/Vomiting severity assessed using the Pediatric Nausea Assessment Tool (PeNAT-scale) + a single Question on Vomiting for ages 5-18. The MASCC Anti-emesis Tool (MAT) will be used to assess nausea (yes/no) and severity for ages 19+.
- Decreased nausea (PeNAT)
- Decreased vomiting (from Vol, 2016)
- (and 14 more...)
|
390 |
All |
5 Years to 21 Years (Child, Adult) |
NCT03313193 |
UCSF-IRB 17-23049 |
ACT-CC |
September 26, 2017 |
May 15, 2020 |
June 1, 2020 |
October 18, 2017 |
January 29, 2018 |
|
- UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California, United States
|
| 50 |
NCT03118986 |
Recruiting |
RCT of Olanzapine for Control of CIV in Children Receiving HSCT Conditioning |
- Vomiting in Infants and/or Children
- Nausea
- Hematopoietic System--Cancer
|
- Drug: Olanzapine
- Drug: Placebo Oral Tablet
|
Interventional |
Phase 2 |
- The Hospital for Sick Children
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Supportive Care
|
- Rate of CIV control during the acute phase
- complete CINV control
- Safety profile of olanzapine based on toxicities
- (and 10 more...)
|
200 |
All |
30 Months to 18 Years (Child, Adult) |
NCT03118986 |
1000053716 |
|
August 10, 2017 |
June 2021 |
November 2021 |
April 18, 2017 |
August 29, 2017 |
|
- Hospital for Sick Children
Toronto, Ontario, Canada
|
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