| 1 |
NCT03430258 |
Not yet recruiting |
High-flow Nasal Cannula Oxygen Therapy With the Chest Trauma Patients |
- Blunt Thoracic Injury
- Lung Ultrasound Score
|
- Device: high-flow nasal cannula
- Device: Conventional oxygen therapy
|
Interventional |
Not Applicable |
- Second Affiliated Hospital, School of Medicine, Zhejiang University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- compare the effectiveness of high-flow nasal cannula with conventional oxygen therapy in ICU patients with blunt thoracic injury.
- number of days in ICU
|
90 |
All |
18 Years and older (Adult, Senior) |
NCT03430258 |
19850703 |
|
March 1, 2018 |
March 30, 2019 |
March 30, 2019 |
February 12, 2018 |
February 12, 2018 |
|
|
| 2 |
NCT03403192 |
Recruiting |
EZ-blocker Versus Left Sided Double Lumen Tube in Adult Patients for Thoracic Surgery |
|
- Device: EZ-Blocker
- Device: DLT
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Supportive Care
|
- Number of DLT or BB replacements
- Differences in time it takes to place for DLT and EZ
- Quality of lung isolation between devices
- Side effects of devices
|
160 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03403192 |
IRB00038220 |
|
January 26, 2018 |
December 2018 |
December 2018 |
January 18, 2018 |
February 5, 2018 |
|
- Wake Forest Baptist Hospital
Winston-Salem, North Carolina, United States
|
| 3 |
NCT03050502 |
Not yet recruiting |
The Management of Traumatic Hemothoraces |
- Hemothorax
- Thoracic Injuries
|
- Device: Chest tube drain
- Other: Expectant management
|
Interventional |
Not Applicable |
- University of Calgary
- Alberta Health Services
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The numbers of hemothoraces that require thoracic interventions.
- The days of mechanical ventilation in intensive care unit
- The days of intensive care unit stay
|
200 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT03050502 |
REB16-1056 |
HemoTxRCT |
February 2018 |
March 2020 |
December 2020 |
February 13, 2017 |
October 31, 2017 |
|
- Foothills Medical Centre, Faculty of Medicine
Calgary, Alberta, Canada
|
| 4 |
NCT03367442 |
Not yet recruiting |
Driving Pressure in Trauma |
- Sever Chest Trauma
- Mechanical Ventilation
|
|
Observational |
|
- University Hospital, Montpellier
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Duration of mechanical Ventilation
- During of SDRA
- Length of stay in intensive care unit
- (and 3 more...)
|
50 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT03367442 |
RECHMPL17_0354 |
|
January 1, 2018 |
February 1, 2019 |
February 1, 2020 |
December 8, 2017 |
December 8, 2017 |
|
- Uhmontpellier
Montpellier, France
|
| 5 |
NCT03396692 |
Not yet recruiting |
PEF-Block & Ribs Fractures |
- Chest Trauma With Ribs Fractures
|
- Procedure: Intravenous morphine patient-controlled analgesia (PCA)
- Procedure: Block of the posterior exo-thoracic fascia with Ropivacaine
- Procedure: Block of paravertebral space with Ropivacaine
|
Interventional |
Not Applicable |
- University Hospital, Montpellier
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Consumption of opoïd
- cough pain intensity
|
90 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03396692 |
UF 9860 |
PEF |
January 15, 2018 |
January 15, 2018 |
December 20, 2020 |
January 11, 2018 |
January 11, 2018 |
|
|
| 6 |
NCT03023982 |
Not yet recruiting |
Pectoralis and Serratus Nerves Block in Thoracic Surgery |
- Anesthesia
- Surgery
- Block
- Thoracic Injury
|
- Drug: Bupivacaine Hydrochloride
- Device: Ultrasound
- Procedure: Thoracotomy
- (and 2 more...)
|
Interventional |
Phase 2 |
- Soroka University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Comparison Visual Analog Score between groups
- Total NSAIDs dosage (mg) in the PACU and department
- Length of hospital stay
- Total morphine dosage (mg) in the PACU and department
|
168 |
All |
18 Years and older (Adult, Senior) |
NCT03023982 |
SOR 34516 CTIL |
|
February 2017 |
February 2019 |
February 2019 |
January 18, 2017 |
January 18, 2017 |
|
|
| 7 |
NCT01367951 |
Recruiting |
Treatment of Acute, Unstable Chest Wall Injuries |
- Blunt Injury of Thorax
- Flail Chest
- Chest Wall Injury Trauma
- Rib Fracture
|
- Procedure: Surgical fixation
|
Interventional |
Not Applicable |
- St. Michael's Hospital, Toronto
- Sunnybrook Health Sciences Centre
- Hamilton Health Sciences Corporation
- (and 4 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ventilator-free days (VFD)
- Number of days in the Intensive Care Unit (ICU)
- Amount of pain medication administration, converted to oral morphine equivalence
- (and 4 more...)
|
206 |
All |
16 Years to 85 Years (Child, Adult, Senior) |
NCT01367951 |
Unstable chest wall injuries |
|
July 2011 |
March 2018 |
December 2020 |
June 7, 2011 |
November 27, 2017 |
|
- St. Michael's Hospital
Toronto, Ontario, Canada
|
| 8 |
NCT02749968 |
Not yet recruiting |
Intercostal Liposomal Bupivacaine for the Management of Blunt Chest Wall Trauma |
- Blunt Chest Wall Trauma
- Rib Fracture
- Sternal Fracture
|
- Drug: Liposomal bupivacaine
- Drug: 0.9% sodium chloride
|
Interventional |
Phase 2 |
- University of Cincinnati
- United States Air Force
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Opioid requirement at 6 hours post-randomization
- Opioid requirement at 12 hours post-randomization
- Opioid requirement at 18 hours post-randomization
- (and 15 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02749968 |
Droege 2016 |
|
January 2018 |
February 2020 |
August 2020 |
April 25, 2016 |
October 30, 2017 |
|
- University of Cincinnati Medical Center
Cincinnati, Ohio, United States
|
| 9 |
NCT02295098 |
Recruiting |
Comparison of Epidural and Paracostal Catheter Placement for Pain Control After Rib Fractures |
- Rib Fractures
- Wounds and Injuries
|
- Other: Thoracic epidural catheter placement
- Other: Paracostal catheter placement
|
Interventional |
Not Applicable |
- University of Colorado, Denver
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Pain assessment immediately before and after catheter placement
- successful placement of randomized intervention (paracostal vs. epidural catheter)
- Comparison of analgesic effect as measured by daily pain scores
- (and 10 more...)
|
200 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02295098 |
14-1979 |
|
August 2015 |
June 2017 |
June 2017 |
November 20, 2014 |
December 7, 2016 |
|
- Denver Health Medical Center
Denver, Colorado, United States
|
| 10 |
NCT03413059 |
Not yet recruiting |
Thoracic Epidural Analgesia in Flail Chest |
|
- Drug: Morphine Sulfate
- Drug: Triamcinolone Acetonide
|
Interventional |
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- visual analogue score
- ICU stay
- chest infection
- hospital stay
|
40 |
All |
18 Years to 60 Years (Adult) |
NCT03413059 |
IRB1000 |
|
February 1, 2018 |
July 1, 2018 |
July 1, 2018 |
January 29, 2018 |
January 29, 2018 |
|
|
| 11 |
NCT03017157 |
Not yet recruiting |
Subclinical Hypothyroidism and Acute Anterior Myocardial Infarction: Is it Cardio-protective or Not? |
|
- Other: Echo-cardiogram
- Other: Blood test
|
Observational |
|
- Hillel Yaffe Medical Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Ejection Fraction Improvement
- Improvement in thyroid function
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT03017157 |
0096-16-HYMC |
|
January 2017 |
April 2017 |
April 2017 |
January 11, 2017 |
January 11, 2017 |
|
- Hillel Yaffe Medical Center
Hadera, Israel
|
| 12 |
NCT03487458 |
Recruiting
New |
Quality of Life in Patients With Traumatic Rib Fracture After Rib Fracture Surgery |
|
- Procedure: Rib Fixation Surgery
|
Interventional |
Not Applicable |
- National Taiwan University Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Short Form-36 (SF-36)
- Work Quality Index (WQI)
- Days of admission
- (and 2 more...)
|
50 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03487458 |
201703114RIND |
|
June 13, 2017 |
June 12, 2018 |
June 12, 2018 |
April 4, 2018 |
April 4, 2018 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
| 13 |
NCT02749409 |
Not yet recruiting |
Early Parecoxib Usage to Decreases Narcotic Requirement and Length of Stay After Traumatic Rib Fracture |
|
- Drug: Parecoxib
- Drug: Morphine
|
Interventional |
Phase 3 |
- Chang Gung Memorial Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
|
204 |
All |
18 Years and older (Adult, Senior) |
NCT02749409 |
PARECOXIB RIB |
|
July 2016 |
July 2018 |
July 2018 |
April 25, 2016 |
July 12, 2016 |
|
|
| 14 |
NCT02608541 |
Recruiting |
Sheffield Multiple Rib Fractures Study: |
|
- Other: rib fracture fixation
|
Observational |
|
- Sheffield Teaching Hospitals NHS Foundation Trust
- University of Sheffield
|
Other |
- Observational Model: Cohort
- Time Perspective: Other
|
- Acute Pain
- Forced Expired Volume in 1 second (FEV1)
- Forced Vital Capacity (FVC)
- (and 9 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT02608541 |
STH19022
183712 |
SMuRFS |
October 12, 2015 |
December 2017 |
December 2017 |
November 18, 2015 |
December 22, 2017 |
|
- Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, South Yorkshire, United Kingdom
|
| 15 |
NCT02595593 |
Recruiting |
Rib Fixation for Clinically Severe Rib Fractures From Trauma |
|
- Device: Rib Fixation System
|
Interventional |
Not Applicable |
- Darwin Ang
- SCRI Development Innovations, LLC
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- ICU Length of Stay
- Quality of Life, as determined by SF-36 survey
- Number of participants with pneumonia as defined by the Centers for Disease Control
- Total cost of treatments
|
300 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02595593 |
SCRI HEOR_02 |
|
April 2015 |
December 2018 |
June 2019 |
November 3, 2015 |
May 4, 2017 |
|
- Lawnwood Regional Medical Center
Fort Pierce, Florida, United States - Fort Walton Beach Medical Center
Fort Walton Beach, Florida, United States - Osceola Regional Medical Center
Kissimmee, Florida, United States - (and 6 more...)
|
| 16 |
NCT03305666 |
Recruiting |
Trial of Injected Liposomal Bupivacaine vs Bupivacaine Infusion After Surgical Stabilization of Rib Fractures |
- Drug Effect
- Rib Fractures
- Rib Trauma
- (and 9 more...)
|
- Drug: Liposomal bupivacaine injection
- Drug: Bupivacaine indwelling catheter
|
Interventional |
Phase 4 |
- Denver Health and Hospital Authority
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Daily Standardized Assessment of Respiratory Function (SCARF) score
- Daily narcotic requirements using equi-analgesic doses
|
34 |
All |
18 Years and older (Adult, Senior) |
NCT03305666 |
17-0685 |
|
October 5, 2017 |
April 2019 |
October 2020 |
October 10, 2017 |
October 10, 2017 |
|
- Denver Health
Denver, Colorado, United States
|
| 17 |
NCT02259452 |
Recruiting |
Radiation Induced Cardiopulmonary Injury in Humans |
- Thoracic
- Pulmonary Injury
- Heart Injuries
|
- Procedure: SPECT Lung Perfusion Scan
- Procedure: SPECT Heart Perfusion Scan
- Procedure: Pulmonary Function Tests
|
Observational |
|
- UNC Lineberger Comprehensive Cancer Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Changes in Regional Lung Function
- Changes in Regional Heart Function
- Relating RT-Induced Changes in Regional injury to Global Cardiopulmonary Changes
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT02259452 |
LCCC0808 |
|
June 2008 |
May 2018 |
|
October 8, 2014 |
July 11, 2017 |
|
- University of North Carolina at Chapel Hill, Department of Radiation Oncology
Chapel Hill, North Carolina, United States
|
| 18 |
NCT02978885 |
Recruiting |
Imaging of periOP Lung Injury |
- Acute Lung Injury
- Chronic Obstructive Pulmonary Disease (COPD)
|
- Radiation: SPECT-CT imaging
- Drug: AxV-128/Tc
|
Interventional |
Phase 2 |
- Columbia University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Correlation of AxV-128/Tc uptake and fibrinogen
- Correlation of AxV-128/Tc uptake and C-Reactive Protein (CRP)
- Correlation of AxV-128/Tc uptake and White Blood Cell (WBC) count
- (and 5 more...)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02978885 |
AAAR0395
1R01HL131960-01 |
|
October 2017 |
July 2018 |
July 2019 |
December 1, 2016 |
September 20, 2017 |
|
- Columbia University Medical Center
New York, New York, United States
|
| 19 |
NCT03473093 |
Not yet recruiting |
Oral Pregabalin Effect to the Intravenous Morphine in Multiple Fracture Ribs |
|
- Drug: Pregabalin 150mg
- Drug: Morphine
|
Interventional |
Early Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- decrease pain
- I.C.U stay time
|
80 |
All |
18 Years to 50 Years (Adult) |
NCT03473093 |
pain in multiple fracture ribs |
|
March 2018 |
March 2019 |
April 2019 |
March 22, 2018 |
March 23, 2018 |
|
|
| 20 |
NCT03431129 |
Not yet recruiting |
Hyperpolarized 129Xe Magnetic Resonance Imaging for Evaluation of Radiation-Induced Lung Injury in Subjects Undergoing Thoracic Irradiation |
- Radiation Induced Lung Injury (RILI)
|
- Diagnostic Test: Hyperpolarized gas and proton lung MRI
|
Observational |
|
- The Hospital for Sick Children
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT03431129 |
1000056200 |
RILI MRI |
May 2018 |
March 2020 |
March 2020 |
February 13, 2018 |
April 18, 2018 |
|
- The Hospital for Sick Children
Toronto, Ontario, Canada
|
| 21 |
NCT02635165 |
Recruiting |
Medico-Economic Analysis of Management of Flail Chest Between Medical Treatment and Surgical Treatment With Stracos |
- Polytraumatises With Rib Fractures
|
- Device: Thoracic osteosyntheses with Stracos
|
Interventional |
Not Applicable |
- Poitiers University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Average cost hospitalization
- length of hospital stays of the intensive care department
- length of hospital stays
- (and 9 more...)
|
310 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02635165 |
2014-A01844-43 |
EMVOLS |
November 2015 |
November 2019 |
December 2020 |
December 18, 2015 |
February 5, 2018 |
|
- Hospital University of Poitiers
Poitiers, France
|
| 22 |
NCT03435913 |
Not yet recruiting |
Transpulmonary Driving Pressure and Intra-abdominal Pressure Relationship During Laparoscopic Surgery |
- Anesthesia, General/Methods
- Laparoscopy
- Respiration, Artificial
- (and 3 more...)
|
- Other: Standard PEEP ventilation
- Other: Matched PEEP ventilation
|
Interventional |
Not Applicable |
- Hospital Universitario La Fe
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Transpulmonary driving pressure (TpDp) difference between standard and matched PEEP ventilation
- Transpulmonary driving pressure and intra-abdmominal pressure relationship (multivariate adaptive linear regression)
- Transpulmonary driving pressure and respiratory driving pressure (RDp) relationship (multivariate adaptive linear regression).
- (and 4 more...)
|
25 |
All |
18 Years and older (Adult, Senior) |
NCT03435913 |
2016/0602 |
|
April 2018 |
August 2018 |
November 2018 |
February 16, 2018 |
April 13, 2018 |
|
- Hospital Universitario La Fe
Valencia, Spain
|
| 23 |
NCT03410511 |
Recruiting |
Propylene Glycol/Glycerol Intake and Cardiorespiratory Function |
|
- Other: Nicotine free intake
- Other: Nicotine intake
- Other: Cessation intake
|
Interventional |
Not Applicable |
- Université Libre de Bruxelles
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Change in cardiorespiratory function
- Change in serum and urine proteomics profiles
|
21 |
Male |
18 Years to 60 Years (Adult) |
NCT03410511 |
P2016/466 / B406201629930 |
PGGICF |
January 15, 2018 |
June 1, 2018 |
September 1, 2018 |
January 25, 2018 |
February 28, 2018 |
|
- Erasme Hospital
Brussels, Anderlecht, Belgium
|
| 24 |
NCT03405779 |
Recruiting |
A New Ultrasonographic Tool to Assess Pulmonary Strain in the ICU |
- Mechanical Ventilation Complication
- Ventilator-Induced Lung Injury
|
- Procedure: Lung ultrasonography
|
Observational |
|
- Centre hospitalier de l'Université de Montréal (CHUM)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Average absolute lateral deformation
- Cumulated range of absolute lateral deformation
- Average absolute axial deformation
- (and 4 more...)
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT03405779 |
17.277 |
|
March 12, 2018 |
March 31, 2019 |
March 31, 2019 |
January 23, 2018 |
March 13, 2018 |
|
- Centre Hospitalier de l'Université de Montréal (CHUM)
Montréal, Quebec, Canada
|
| 25 |
NCT03367221 |
Recruiting |
Physiological Response in Lung Transplant Recipients Undergoing Neurally Adjusted Ventilatory Assist |
- Work of Breathing
- Lung Transplant; Complications
- Neurally Adjusted Ventilatory Assist
- Ventilator-Induced Lung Injury
|
|
Interventional |
Not Applicable |
- Policlinico Hospital
- University of Lausanne Hospitals
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Evaluation of the variations of Electrical Activity of the Diaphragm in response to different levels of ventilatory assist at different degrees of lung inflation (different Positive End Expiratory Pressure values)
- Evaluation of the variations of Neuro-Mechanical Coupling (expressed as microVolt of EAdi /cmH2O of airway pressure Ratio) in response to different levels of ventilatory assist at different degrees of lung inflation
- Evaluation of the variations of Neuro-ventilatory Efficiency (expressed as microvolt of EAdi / mL of Tidal Volume Ratio) in response to different levels of ventilatory assist at different degree of lung inflation
- (and 5 more...)
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03367221 |
TRANS-NAVA |
TRANS-NAVA |
November 23, 2017 |
November 2019 |
November 2019 |
December 8, 2017 |
December 8, 2017 |
|
- Ospedale Maggiore Policlinico
Milan, Italy - University Hospital of Lausanne
Lausanne, Switzerland
|
| 26 |
NCT03328117 |
Recruiting |
A Study to Investigate the Effects of Imatinib on Pulmonary Vascular Dysfunction in a Human Model of Lung Injury |
|
- Drug: Imatinib
- Drug: Placebo oral capsule
|
Interventional |
Phase 1 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in the number of neutrophils in bronchoalveolar lavage fluid in subjects exposed to imatinib compared with placebo
- Change in concentration of total protein in bronchoalveolar lavage fluid in subjects exposed to imatinib compared with placebo
|
40 |
All |
18 Years to 55 Years (Adult) |
NCT03328117 |
EXV001
2017-002203-10 |
|
November 13, 2017 |
March 2018 |
June 2018 |
November 1, 2017 |
November 17, 2017 |
|
- PAREXEL Early Phase Clinical Unit
London, United Kingdom
|
| 27 |
NCT03245684 |
Not yet recruiting |
Assisted or Controlled Ventilation in Ards (Ascovent) |
- ARDS
- Ventilator-Induced Lung Injury
- Mechanical Ventilation Complication
- Inflammatory Response
|
- Diagnostic Test: assessment of inflammatory response during PSV
|
Interventional |
Not Applicable |
- University of Roma La Sapienza
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Pulmonary concentration of inflammation mediators (broncho-alveolar lavage: BAL)
- Systemic concentration of inflammation mediators (plasma)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03245684 |
ASCOVENT |
ASCOVENT |
September 1, 2017 |
September 1, 2019 |
September 1, 2019 |
August 10, 2017 |
August 10, 2017 |
|
|
| 28 |
NCT03212690 |
Not yet recruiting |
Study of Renin-angiotensin System in Mechanically Ventilated Subjects |
|
- Drug: Local standard of care
- Procedure: Mechanical ventilation
|
Observational |
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Assessment of Ang II levels
- Ratio of right ventricular to left ventricular end-diastolic area to evaluate association between plasma Ang II levels and RV function
- Assessment of Paradoxical septal motion (systolic eccentricity index) to evaluate association between plasma Ang II levels and RV function
- (and 8 more...)
|
150 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03212690 |
205821 |
|
April 2, 2018 |
September 16, 2019 |
September 16, 2019 |
July 11, 2017 |
September 25, 2017 |
|
|
| 29 |
NCT03135691 |
Recruiting |
Intraop Ventilation Management and Postop Pulmonary Complications in High Risk Patients for OSA |
- Ventilator-Induced Lung Injury
|
|
Observational |
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Post-Operative Pulmonary Complications
|
2636 |
All |
18 Years and older (Adult, Senior) |
NCT03135691 |
2016H0423 |
|
March 18, 2017 |
December 2018 |
December 2018 |
May 1, 2017 |
May 15, 2017 |
|
- The Ohio State University Wexner Medical Center
Columbus, Ohio, United States
|
| 30 |
NCT03041428 |
Recruiting |
Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO) |
- Cardiogenic Pulmonary Edema
- Ventilator-Induced Lung Injury
- Extracorporeal Circulation; Complications
|
- Device: Ultraprotective ventilation
|
Interventional |
Not Applicable |
- Fundación para la Investigación Biosanitaria del Principado de Asturias
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in lung inflammatory mediators levels
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03041428 |
FINBA_CritLab_1 |
UPV-ECMO |
February 1, 2017 |
December 31, 2018 |
March 31, 2019 |
February 2, 2017 |
February 13, 2018 |
|
- Hospital Universitario Central de Asturias (HUCA)
Oviedo, Principado De Asturias, Spain
|
| 31 |
NCT03023670 |
Recruiting |
Lung Protection and Pediatric Cardiac Surgery |
|
- Procedure: cardiopulmonary bypass
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change from Baseline Computerized tomography chest (CT chest) within 7 days postoperative
- Mechanical ventilation
- Intensive care unit stay
- (and 2 more...)
|
60 |
All |
2 Years to 10 Years (Child) |
NCT03023670 |
IRB0000871180 |
|
January 2017 |
October 2017 |
November 2017 |
January 18, 2017 |
October 19, 2017 |
|
- Faculty of Medicine
Assiut, Egypt
|
| 32 |
NCT03019354 |
Recruiting |
The Effect of Using High-flow Nasal Oxygen-delivery System in Patients Under Intravenous General Anesthesia |
- Pulmonary Atelectases
- Lung Injury
- General Anesthesia
|
- Device: high-flow nasal oxygen
- Device: Oxygen mask
|
Interventional |
Not Applicable |
- National Taiwan University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Chest CT image atelectatic area
- postoperative pulmonary complications
- lung injury
|
60 |
All |
20 Years and older (Adult, Senior) |
NCT03019354 |
201611036RIN |
|
January 2017 |
January 2018 |
January 2018 |
January 12, 2017 |
January 20, 2017 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
| 33 |
NCT02891837 |
Recruiting |
L-citrulline for Prevention of Sequelae of Acute Lung Injury in Pediatrics Undergoing Cardiopulmonary Bypass for Heart Defects |
|
- Drug: L-citrulline
- Other: Placebo
|
Interventional |
Phase 3 |
- Asklepion Pharmaceuticals, LLC
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- A composite variable consisting of the longer of either (1) length of time on mechanical ventilation or (2) length of inotrope use.
- Length of time on mechanical ventilation
- Length of time on positive pressure ventilation
- (and 16 more...)
|
190 |
All |
up to 18 Years (Child, Adult) |
NCT02891837 |
CIT-003-01
2016-002427-28 |
|
August 2016 |
December 2018 |
April 2019 |
September 8, 2016 |
March 13, 2018 |
|
- University of Alabama
Birmingham, Alabama, United States - University of California Davis Medical Center
Sacramento, California, United States - Children's Hospital Colorado
Aurora, Colorado, United States - (and 19 more...)
|
| 34 |
NCT02693912 |
Not yet recruiting |
Changes in Alveolar Macrophage Function During Acute Lung Injury |
|
|
Observational |
|
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- alveolar macrophages (AMs) phagocytic index
- 30 days mortality
|
25 |
All |
18 Years and older (Adult, Senior) |
NCT02693912 |
wch-150718 |
|
September 2016 |
December 2017 |
August 2018 |
February 29, 2016 |
February 29, 2016 |
|
|
| 35 |
NCT02583984 |
Not yet recruiting |
Metabolomic Study in Exhaled Breath Condensate of Thoracic Surgical Patients |
- Acute Pulmonary Insufficiency Following Thoracic Surgery
- Ventilator-associated Lung Injury
|
- Procedure: Thoracic Surgery with Lung Resection
- Procedure: Thoracic Surgery without Lung Resection
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of participants with acute lung injury following thoracic surgery
- Metabolome of exhaled breath condensate associated with lung injury in thoracic surgery
|
40 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT02583984 |
201505133RINC |
|
March 2017 |
March 2018 |
March 2018 |
October 22, 2015 |
May 25, 2016 |
|
- Department of Anesthesiology, National Taiwan University Hospital
Taipei City, Taiwan
|
| 36 |
NCT02386683 |
Recruiting |
Intraoperative Lung-Protective Ventilation in Neurosurgery |
- Ventilator-induced Lung Injury
|
- Other: lung-protective ventilation
|
Interventional |
Not Applicable |
- Capital Medical University
- Beijing Tiantan Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Postoperative pulmonary complications
- Intraoperative brain relaxation.
- The postoperative complications within 30 days
- (and 7 more...)
|
360 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT02386683 |
kY2014-031-02 |
|
October 2015 |
March 2018 |
November 2018 |
March 12, 2015 |
October 3, 2017 |
|
- Department of Anesthesiology,Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing, China
|
| 37 |
NCT03314701 |
Not yet recruiting |
Mechanical Ventilation in Multiple Fracture Ribs |
|
- Device: Biphasic Intermittent Positive Airway Pressure (BIPAP)
- Device: Airway Pressure Release Ventilation (APRV)
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Duration of mechanical ventilation
- Resting Energy Expenditure
- Physiological dead space
|
60 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03314701 |
IRB0000879659 |
|
October 2017 |
October 2018 |
December 2018 |
October 19, 2017 |
October 19, 2017 |
|
- Faculty of Medicine
Assiut, Egypt
|
| 38 |
NCT03016182 |
Recruiting |
Remote Ischemic Preconditioning on Pulmonary Injury in Cardic Surgery |
- Lung Injury
- Remote Ischemic Preconditioning
|
- Procedure: Remote Ischemic Preconditioning
- Procedure: Control
|
Interventional |
Not Applicable |
- Xuzhou Medical University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Comparison of PaO2/FiO2 over 24 hours after cardiac surgery
- All-cause mortality
- Postoperative Pulmonary Complications
|
60 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03016182 |
XYFY-2017-004 |
|
February 7, 2017 |
February 2018 |
February 2018 |
January 10, 2017 |
February 23, 2017 |
|
- The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
|
| 39 |
NCT02918877 |
Recruiting |
Anesthetics to Prevent Lung Injury in Cardiac Surgery |
- Inflammatory Lung Injury
- Ischemia-Reperfusion Lung Injury
- Postoperative Pulmonary Complications
|
- Drug: Sevoflurane
- Drug: Propofol
|
Interventional |
Phase 1
Phase 2 |
- Beth Israel Deaconess Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Bronchoalveolar Lavage (BAL) Concentration of TNF alpha (ng/L)
- Postoperative Pulmonary Complications
- BAL concentration of IL1b (ng/L)
- (and 5 more...)
|
45 |
All |
18 Years and older (Adult, Senior) |
NCT02918877 |
2016P000306 |
APLICS |
June 9, 2017 |
October 2018 |
October 2018 |
September 29, 2016 |
June 12, 2017 |
|
- Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
| 40 |
NCT03401463 |
Recruiting |
Assesment of the Endotracheal Tube Cuff Pressure Values in ICU Pateints Before and After Training Seminar |
- Respiratory Tract Diseases
- Respiratory Tract Infections
- Pneumonia, Ventilator-Associated
- Ventilator-Induced Lung Injury
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- monitoring of cuff pressures
- preventing complications of incorrect pressure in tracheal cuff
|
1000 |
All |
18 Years and older (Adult, Senior) |
NCT03401463 |
1072.6120.194.2017 |
|
October 26, 2017 |
December 31, 2018 |
December 31, 2018 |
January 17, 2018 |
January 17, 2018 |
|
- University Hospital
Kraków, Poland
|
| 41 |
NCT03076983 |
Recruiting |
Assessment of the Capability of PulmoVista 500 to Continuously Monitor Changes of Ventilation Over Time |
- Mechanical Ventilation
- Single-lung Ventilation
- ARDS
- (and 2 more...)
|
- Device: Lung Monitoring with EIT device (PulmoVista 500)
|
Observational |
|
- Drägerwerk AG & Co. KGaA
- KKS Dresden
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Monitoring capabilities of PulmoVista 500
- Detection of changes in regional ventilation
- Assess changes of tidal volumes
- (and 3 more...)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT03076983 |
PV500 |
|
April 1, 2017 |
September 30, 2017 |
September 30, 2017 |
March 10, 2017 |
June 22, 2017 |
|
- Klinikum Bremerhaven-Reinkenheide gGmbH
Bremerhaven, Germany - Universitätsklinik Dresden
Dresden, Germany - Medizinische Hochschule Hannover (MHH)
Hannover, Germany
|
| 42 |
NCT02948530 |
Recruiting |
Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods (Lungbarometry) |
|
|
Observational |
|
- Stefan Lundin
- Sahlgrenska University Hospital, Sweden
|
Other |
- Observational Model: Case-Crossover
- Time Perspective: Prospective
|
- Measurement of lung elastance and transpulmonary pressure
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02948530 |
LUA-74204 |
|
October 2016 |
December 2018 |
December 2018 |
October 28, 2016 |
April 11, 2018 |
|
- Sahlgrenska University Hospital
Gothenburg, Sweden
|
| 43 |
NCT02468531 |
Recruiting |
Xenon Against Postoperative Oxygen Impairment |
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- oxygenation index
- alterations in cytokine and ROS in the perioperative period
- extubation time
- complications of vital organs
|
160 |
All |
18 Years to 65 Years (Adult) |
NCT02468531 |
2014.7-2017.7 |
|
January 2015 |
July 2017 |
December 2017 |
June 11, 2015 |
November 9, 2016 |
|
- Beijing Anzhen Hospital
Beijing, Beijing, China
|
| 44 |
NCT03461588 |
Recruiting |
Prospective Assessment of Radiation-induced Heart Injury in Left-sided Breast Cancer |
- Breast Neoplasms
- Heart Injuries
- Radiation Toxicity
|
- Radiation: free-breathing
- Radiation: deep inspiratory breath-holding
|
Interventional |
Not Applicable |
- Shu lian Wang
- Chinese Academy of Medical Sciences
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with treatment-related cardiac adverse events as assessed by CTCAE v4.0
|
100 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT03461588 |
LC2016A09 |
|
January 1, 2017 |
January 30, 2019 |
January 30, 2019 |
March 12, 2018 |
March 12, 2018 |
|
- Cancer Hospital, Chinese Academy of Medical Sciences
Beijing, China - Cancer Hosptical, Chinese Academy of Medical Sciences
Beijing, China
|
| 45 |
NCT02432456 |
Recruiting |
Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients |
- Wounds and Injuries
- Rib Fractures
|
- Drug: Ketamine
- Drug: Placebo
- Procedure: Intercostal Nerve Block
- (and 5 more...)
|
Interventional |
Phase 4 |
- Medical College of Wisconsin
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- AUCpain
- ICU Length of Stay
- Length of Stay
- (and 5 more...)
|
132 |
All |
18 Years and older (Adult, Senior) |
NCT02432456 |
PRO00024679 |
|
September 2015 |
August 2018 |
August 2018 |
May 4, 2015 |
October 26, 2017 |
|
- Froedtert Memorial Lutheran Hospital
Milwaukee, Wisconsin, United States
|
| 46 |
NCT01659307 |
Recruiting |
The Effect of Aspirin on REducing iNflammation in Human in Vivo Model of Acute Lung Injury |
|
- Drug: Aspirin 75mg
- Drug: Lactose powder
- Drug: Aspirin 1200mg
|
Interventional |
Phase 2 |
- Belfast Health and Social Care Trust
- The Intensive Care Society United Kingdom
- Northern Ireland Clinical Trials Unit
- Queen's University, Belfast
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Bronchoalveolar lavage IL-8 concentration
- Alveolar inflammatory response biomarkers
- Plasma inflammatory response biomarkers
- (and 2 more...)
|
33 |
All |
18 Years and older (Adult, Senior) |
NCT01659307 |
11127DMcA-AS
2012-001589-13 |
ARENA |
September 2012 |
August 2017 |
August 2017 |
August 7, 2012 |
February 7, 2017 |
|
- Belfast Health and Social Care Trust
Belfast, United Kingdom
|
| 47 |
NCT03140579 |
Not yet recruiting |
Effect of PEEP on Lung Recruitment and Homogeneity Over Time in Moderate to Severe ARDS |
- ARDS
- Critical Illness
- Ventilator-Induced Lung Injury
|
|
Observational |
|
- Guy's and St Thomas' NHS Foundation Trust
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To compare lung homogeneity estimated with EIT upon commencing APRV (APRVpre) and after 30 - 60 - 120 min of APRV ventilation (APRV30, APRV60, APRV120) in patients with moderate to severe ARDS
- To assess recruitment at the beginning and after the end of APRV ventilation in patients with moderate-severe ARDS.
- To compare lung strain measured at APRVpre and after the end of APRV ventilation (APRVpost) in patients with moderate-severe ARDS
|
15 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03140579 |
123456789 |
APRV |
June 1, 2018 |
December 31, 2018 |
December 31, 2018 |
May 4, 2017 |
January 5, 2018 |
|
- Guys and St Thomas NHS Foundation
London, United Kingdom
|
| 48 |
NCT03095469 |
Not yet recruiting |
Effects of Dexmedetomidine on Patients With Coronary Heart Disease After Percutaneous Coronary Intervention |
|
- Drug: Dexmedetomidine
- Drug: 0.9%NaCl solution
|
Interventional |
Early Phase 1 |
- First Affiliated Hospital Xi'an Jiaotong University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- the incidence of myocardial infarction type 4a (MI4a)
- post-procedural cardiac function
- major adverse cardiac events(MACEs)
- systemic inflammatory markers
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT03095469 |
XJTU1AF-CRF-2016T-09 |
EODOPWCHD |
August 20, 2017 |
November 30, 2017 |
December 31, 2017 |
March 29, 2017 |
June 9, 2017 |
|
- the 1st affiliated hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
|
| 49 |
NCT02613377 |
Recruiting |
Transfusion-related Acute Lung Injury: a Prospective Cohort Study in Critically Ill Children |
|
|
Observational |
|
- St. Justine's Hospital
- Canadian Blood Services
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Transfusion-related acute lung injury
- Length of PICU stay (days)
- 28-day all cause mortality
- Multiple organ dysfunction syndrome (MODS)
|
1476 |
All |
up to 18 Years (Child, Adult) |
NCT02613377 |
CHUSJ-MP-21-2016-1070 |
TRALI |
January 2016 |
May 2018 |
December 2018 |
November 24, 2015 |
April 28, 2017 |
|
- Alberta Children's Hospital
Calgary, Alberta, Canada - McMaster Children's Hospital
Hamilton, Ontario, Canada - Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada - (and 3 more...)
|
| 50 |
NCT01667666 |
Recruiting |
Clinical Trial of Nebulized Hypertonic Saline to Attenuate Post-Traumatic Acute Lung Injury |
- Acute Lung Injury
- Adult Respiratory Distress Syndrome
|
- Drug: Nebulized hypertonic saline
|
Interventional |
Phase 1 |
- Denver Health and Hospital Authority
- University of Colorado, Denver
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- change in the respiratory parameters
- death within 28 days
- lung dysfunction scores
- (and 2 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT01667666 |
COMIRB #11-0706 |
|
May 2012 |
May 2021 |
May 2021 |
August 17, 2012 |
February 2, 2018 |
|
- Denver Health Medical Center
Denver, Colorado, United States
|
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