91 studies found for:    Open Studies | "Scleroderma, Systemic"
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1 Not yet recruiting Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension
Conditions: Scleroderma, Diffuse;   Scleroderma, Systemic;   Scleroderma, Limited;   Sclerosis, Progressive Systemic;   Skin Diseases;   Connective Tissue Diseases;   Pathologic Processes;   Autoimmune Diseases
Interventions: Drug: Oral Ifetroban;   Drug: Oral Placebo
2 Unknown  Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis
Conditions: Scleroderma, Systemic;   Scleroderma, Diffuse;   Scleroderma, Limited;   Raynaud Phenomenon
Interventions: Drug: Sildenafil citrate;   Drug: Placebo
3 Recruiting Safety, Tolerability and Pharmacokinetic Study of MRG-201 in Healthy Volunteers and Patients With Cutaneous Scleroderma
Conditions: Limited Scleroderma;   Localized Scleroderma;   Diffuse Scleroderma
Interventions: Drug: MRG-201;   Drug: Placebo
4 Recruiting Obstructive Sleep Apnea in Scleroderma and Pulmonary Involvement
Conditions: Scleroderma, Systemic;   Sleep Apnea, Obstructive;   Pulmonary Disease
Intervention: Other: No intervention
5 Recruiting Gastroesophageal Reflux Treatment in Scleroderma
Conditions: Gastroesophageal Reflux Disease;   Systemic Sclerosis;   Scleroderma
Interventions: Drug: Alginic acid;   Drug: placebo (for domperidone);   Drug: Domperidone;   Drug: placebo (of alginic acid)
6 Recruiting IVIG Treatment in Systemic Sclerosis
Conditions: Systemic Sclerosis;   Diffuse Scleroderma
Intervention: Biological: Privigen
7 Recruiting Proof-of-concept Trial of IVA337 in Diffuse Cutaneous Systemic Sclerosis
Conditions: Scleroderma, Diffuse;   Diffuse Cutaneous Systemic Sclerosis
Interventions: Drug: IVA337;   Drug: Placebo
8 Recruiting Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease
Conditions: Systemic Sclerosis;   Scleroderma;   Interstitial Lung Disease;   Lung Fibrosis
Interventions: Drug: Cyclophosphamide;   Drug: Placebo
9 Recruiting Allogeneic Hematopoietic Cell Transplantation After Nonmyeloablative Conditioning for Patients With Severe Systemic Sclerosis
Conditions: Systemic Scleroderma;   Severe Systemic Sclerosis
Interventions: Drug: fludarabine phosphate;   Drug: Mycophenolic Acid;   Drug: tacrolimus;   Radiation: total-body irradiation;   Procedure: bone marrow transplantation;   Procedure: reduced intensity allogeneic hematopoietic stem cell transplantation;   Procedure: quality-of-life assessment;   Other: laboratory biomarker analysis;   Other: flow cytometry;   Procedure: biopsy;   Drug: cyclophosphamide
10 Recruiting IL1-TRAP, Rilonacept, in Systemic Sclerosis
Conditions: Scleroderma;   Systemic Sclerosis;   Diffuse Scleroderma;   Diffuse Systemic Sclerosis
Interventions: Drug: Rilonacept;   Drug: Placebo
11 Recruiting Scleroderma Registry
Conditions: Systemic Sclerosis;   Scleroderma
Intervention:
12 Recruiting Scleroderma Registry & Repository at the Hospital for Special Surgery
Condition: Scleroderma
Intervention:
13 Not yet recruiting Oral Manifestations of Systemic Sclerosis
Condition: Scleroderma, Systemic
Intervention: Radiation: Cone Beam Computed Tomography (CBCT)
14 Recruiting Role of Circulating Cytotoxic Lymphocytes in Endothelial Cell Injury in Systemic Sclerosis
Condition: Scleroderma, Systemic
Intervention: Other: blood samples
15 Recruiting Zibotentan Better Renal Scleroderma Outcome Study
Conditions: Scleroderma;   Scleroderma Renal Crisis;   Chronic Kidney Disease
Intervention: Drug: Zibotentan
16 Recruiting Efficacy and Safety of Riociguat in Patients With Systemic Sclerosis
Condition: Scleroderma, Systemic
Interventions: Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
17 Recruiting Scleroderma Treatment With Celution Processed Adipose Derived Regenerative Cells (STAR)
Conditions: Scleroderma;   Systemic Sclerosis;   Raynaud Phenomena;   Raynaud's Disease
Interventions: Device: Celution Device;   Other: Placebo
18 Not yet recruiting The Clinical And Subclinical Effects on Arterial Stiffness of Bosentan in Patients With Systemic Sclerosis
Condition: Scleroderma, Systemic
Intervention: Drug: bosentan
19 Recruiting A Trial to Compare Nintedanib With Placebo for Patients With Scleroderma Related Lung Fibrosis
Condition: Scleroderma, Systemic
Interventions: Drug: Nintedanib;   Drug: Placebo
20 Recruiting Subcutaneous Injection of Autologous Adipose Tissue-derived Stromal Vascular Fraction Into the Fingers of Patients With Systemic Sclerosis
Condition: Scleroderma, Systemic
Interventions: Drug: Stromal Vascular fraction;   Drug: Ringer lactate

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Indicates status has not been verified in more than two years