| 1 |
NCT03213834 |
Recruiting |
Fibrinolytic Therapy Versus Medical Thoracoscopy |
|
- Procedure: Chest thoracoscopy
- Procedure: Chest fibrinolytic therapy
- Drug: tPA
- Drug: DNase
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Duration of hospital days for treatment of complicated parapneumonic effusions or pleural empyema.
- Duration of chest tube
- Duration of entire hospital stay for complete treatment of pleural infection
- (and 4 more...)
|
70 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT03213834 |
IRB201700012 |
|
September 14, 2017 |
April 2019 |
April 2019 |
July 11, 2017 |
March 26, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
| 2 |
NCT03172585 |
Not yet recruiting |
Transthoracic Sonography Versus High Resolution Computed Tomography in Alveolar Intersitial Syndrome |
|
- Other: High resolution computed tomography
- Other: trans thoracic ultrasonography
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- the number of patients diagnosed with pleural diseases by high resolution computed tomography
|
1 |
All |
18 Years and older (Adult, Senior) |
NCT03172585 |
AIS |
|
June 2017 |
June 2018 |
August 2018 |
June 1, 2017 |
June 1, 2017 |
|
|
| 3 |
NCT02414269 |
Recruiting |
Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin |
- Malignant Pleural Disease
- Mesothelioma
- Metastases
- (and 2 more...)
|
- Genetic: iCasp9M28z T cell infusions
- Drug: cyclophosphamide
|
Interventional |
Phase 1 |
- Memorial Sloan Kettering Cancer Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Composite measure of severity and number of adverse events (AEs); changes in clinical laboratory test findings (hematologic and chemistry); and physical examination.
- Changes in serum levels of the biomarker soluble mesothelin related peptide (SMRP)
|
36 |
All |
18 Years and older (Adult, Senior) |
NCT02414269 |
15-007 |
|
May 2015 |
April 2019 |
April 2019 |
April 10, 2015 |
April 12, 2018 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 4 |
NCT02866305 |
Recruiting |
Study Designed to Optimize the Treatment of Primary Pneumothorax |
- Primary Spontaneous Pneumothorax
- Pleural Disease
|
- Procedure: VATS bullectomy and mechanical pleuradesis.
- Procedure: Chest tube insertion
- Drug: Epidural
- Radiation: High-resolution Computer Tomography
|
Interventional |
Early Phase 1 |
- Odense University Hospital
- Danish Medical Association
- Danmarks Lungeforening
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to ipsilateral recurrence
- Number of Participants with Adverse Events as a Measure of Safety and Tolerability
- Length of hospital stay
- Pain according to NRS scale reported at discharge, at 4 weeks, 1 year, 5 years and 10 years.
|
300 |
All |
18 Years to 40 Years (Adult) |
NCT02866305 |
TOPP2009 |
TOPP |
March 2009 |
December 2017 |
December 2024 |
August 15, 2016 |
August 16, 2016 |
|
- Research Unit at the cardiothoracic departement at the University Hospital of Odense
Odense, Fyn, Denmark - Research Unit at the Cardiothoracic Department at the University Hospital of Skejby
Århus, Midtjylland, Denmark - Research Unit at the Cardiothoracic Department af Ålborg Hospital
Ålborg, Nordjylland, Denmark
|
| 5 |
NCT02973139 |
Recruiting |
Fibrinolysis Compared to Thoracoscopy for Pleural Infection |
- Pleural Infection
- Pleural Diseases
|
- Other: Medical Thoracoscopy
- Other: Fibrinolytic Group
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Duration of hospital stay after intervention
- Number of days with chest drainage
- Total length of hospital stay
- (and 6 more...)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT02973139 |
2016P000307 |
|
July 14, 2017 |
November 2018 |
November 2018 |
November 25, 2016 |
August 15, 2017 |
|
- Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
| 6 |
NCT03325192 |
Recruiting |
Rapid Pleurodesis Through an Indwelling Pleural Catheter |
- Pleural Effusion, Malignant
- Pleurodesis
- Pleural Diseases
|
- Drug: Rapid pleurodesis protocol
- Other: Placebo
|
Interventional |
Not Applicable |
- University of Pennsylvania
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time to catheter removal
- Change in Global Health Related Quality of Life
- Change in symptoms of pain and breathlessness
- (and 2 more...)
|
72 |
All |
18 Years and older (Adult, Senior) |
NCT03325192 |
827688 |
RAPID |
December 12, 2017 |
November 2018 |
July 2019 |
October 30, 2017 |
December 14, 2017 |
|
- University of Pennsylvania
Philadelphia, Pennsylvania, United States
|
| 7 |
NCT03290183 |
Recruiting |
Confocal Laser Endomicroscopy in Pleural Malignancies |
- Pleural Malignant Mesothelioma
- Thymoma
- Pleural Diseases
|
- Device: Confocal laser endomicroscopy
|
Observational |
|
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Technical feasibility: Number of successful procedures with evaluable CLE-imaging
- Procedure-related adverse events
- To describe and develop visual descriptive image criteria (number of descriptive criteria based on CLE imaging)
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03290183 |
NL60800.018.17 |
|
August 28, 2017 |
August 28, 2018 |
March 1, 2019 |
September 21, 2017 |
September 21, 2017 |
|
- NKI-AvL
Amsterdam, Noord-Holland, Netherlands - Academic Medical Center
Amsterdam, Noordd-Holland, Netherlands
|
| 8 |
NCT03468933 |
Recruiting |
Fibrinolysis Compared to Thoracoscopy for Pleural Infection |
- Pleural Infection
- Empyema
- Pleural Diseases
- Parapneumonic Effusion
|
- Drug: tissue plasminogen activator (tPA) and human recombinant deoxyribonuclease (DNase)
- Procedure: Medical Thoracoscopy
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Duration of hospital stay after intervention
- Number of days with chest drainage
- Total length of hospital stay
- (and 6 more...)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT03468933 |
1070390 |
|
November 1, 2017 |
November 30, 2018 |
November 30, 2018 |
March 19, 2018 |
March 19, 2018 |
|
- Tulane Medical Center Tulane University Section of Pulmonary DiseasesTulane University Section of Pulmonary Diseases
New Orleans, Louisiana, United States
|
| 9 |
NCT02891642 |
Not yet recruiting |
Liquid Biopsy With Immunomagnetic Beads Capture Technique for Malignant Cell Detection in Body Fluid |
- Malignancy
- Pleural Effusion
- Pleural Diseases
- Ascites
|
- Device: Immunomagnetic Detection
|
Observational |
|
- The First Affiliated Hospital with Nanjing Medical University
- University of California, Los Angeles
- M.D. Anderson Cancer Center
- (and 6 more...)
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Number of Participants with Malignancies Assessed by the Liquid Biopsy with Immunomagnetic Beads Capture Technique (Cancer Cell Positive Enrichment)
|
1000 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02891642 |
Laboratory Medicine-001 |
|
September 2016 |
February 2018 |
February 2018 |
September 7, 2016 |
September 7, 2016 |
|
- The First Affiliated Hospital with Nanjing Medical University
Nanjin, Jiangsu, China
|
| 10 |
NCT03210298 |
Recruiting |
International Registry of Patients Treated With Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) |
- Peritoneum Cancer
- Peritoneum Neoplasm
- Pleural Cancer
- (and 12 more...)
|
- Combination Product: PIPAC
|
Observational |
|
- Sabine Rhode
- Ruhr University of Bochum
- University of Magdeburg
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Overall survival
- Clinical Benefit Rate
- Histological tumor regression according to the Peritoneal Regression Grading Score (PRGS)
- (and 2 more...)
|
1000 |
All |
10 Years and older (Child, Adult, Senior) |
NCT03210298 |
RUB 15-5280 |
PIPACRegis |
January 2016 |
May 2018 |
May 2019 |
July 6, 2017 |
July 13, 2017 |
|
- Roffo Cancer Institute
Buenos Aires, Argentina - Peter MacCallum Cancer Centre
Melbourne, Australia - University Hospital Gent (UZ Gent)
Gent, Belgium - (and 11 more...)
|
| 11 |
NCT03488043 |
Not yet recruiting
New |
Predictive Score of PneumOThorax Secondary to CT-guided Transthoracic Lung Biopsy Made From a Large Retrospective Cohort and Validated on a Prospective Cohort |
|
- Procedure: Needle lung biopsy
|
Observational |
|
- Centre Hospitalier Universitaire de Besancon
|
Other |
- Observational Model: Cohort
- Time Perspective: Other
|
|
1000 |
All |
18 Years and older (Adult, Senior) |
NCT03488043 |
P/2018/372 |
SPOT |
April 2018 |
April 2019 |
April 2019 |
April 4, 2018 |
April 4, 2018 |
|
|
| 12 |
NCT03480490 |
Not yet recruiting
New |
Evaluation and Outcome of Para-pneumonic Effusion |
|
- Diagnostic Test: Pleural fluid C-reactive protein
|
Observational |
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
|
25 |
All |
1 Month to 18 Years (Child, Adult) |
NCT03480490 |
EOPE |
|
January 1, 2019 |
January 1, 2020 |
May 2020 |
March 29, 2018 |
March 29, 2018 |
|
|
| 13 |
NCT03465774 |
Recruiting |
Indwelling Pleural Catheters Versus Indwelling Pleural Catheters Plus Doxycycline |
- Malignant Neoplasms of Respiratory and Intrathoracic Organs
|
- Behavioral: Surveys
- Drug: Fentanyl
- Drug: Doxycycline
|
Interventional |
Early Phase 1 |
- M.D. Anderson Cancer Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to Indwelling Pleural Catheter (IPC) Removal
- Fluid Recurrence after Indwelling Pleural Catheter (IPC) Removal
- Symptom Burden Determined by Patient Self Assessment Form
|
208 |
All |
18 Years and older (Adult, Senior) |
NCT03465774 |
2017-0973
NCI-2018-00630 |
|
March 8, 2018 |
December 2019 |
December 2020 |
March 14, 2018 |
April 20, 2018 |
|
- University of Texas MD Anderson Cancer Center
Houston, Texas, United States
|
| 14 |
NCT03449602 |
Recruiting |
Minirigid Versus Conventional Rigid Thoracoscopy in Undiagnosed Pleural Effusions |
|
- Device: Mini-thoracoscopy
- Device: Conventional rigid thoraoscopy
|
Interventional |
Not Applicable |
- Postgraduate Institute of Medical Education and Research
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Diagnostic sensitivity (intention-to-treat)
- Diagnostic sensitivity (per protocol)
- Sedative and analgesic dose
- (and 8 more...)
|
100 |
All |
15 Years to 80 Years (Child, Adult, Senior) |
NCT03449602 |
NK/3695/Res |
MICRO |
March 1, 2018 |
February 28, 2020 |
March 1, 2020 |
February 28, 2018 |
March 22, 2018 |
|
- Postgraduate Institute of Medical Education and Research
Chandigarh, India
|
| 15 |
NCT03397290 |
Not yet recruiting |
Bedside Ultrasound in Detection of Pneumothorax Post Transthoracic Lung Biopsy |
|
- Device: Ultrasound (US) Imaging
|
Interventional |
Not Applicable |
- Ottawa Hospital Research Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
|
300 |
All |
Child, Adult, Senior |
NCT03397290 |
20170774-01H |
|
February 2018 |
February 2019 |
November 2019 |
January 11, 2018 |
January 11, 2018 |
|
- Hamid Bayanati
Ottawa, Ontario, Canada
|
| 16 |
NCT03394118 |
Recruiting |
TAGRISSO (Osimertinib) in NSCLC Patients in Whom T790 Mutations Are Detected by Liquid Biopsy Using BALF, Plasma or Pleural Effusion |
|
|
Interventional |
Phase 2 |
- Asan Medical Center
- AstraZeneca
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
63 |
All |
20 Years and older (Adult, Senior) |
NCT03394118 |
C2016-00578_ESR-16-11898 |
|
August 11, 2017 |
July 2018 |
July 2019 |
January 9, 2018 |
January 9, 2018 |
|
- Asan Medical Center
Seoul, Korea, Republic of
|
| 17 |
NCT03319472 |
Recruiting |
Using Pleural Effusions to Diagnose Cancer |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
1080 |
All |
18 Years and older (Adult, Senior) |
NCT03319472 |
22699/21.11.2013 |
MAPED |
November 21, 2013 |
November 21, 2023 |
November 21, 2023 |
October 24, 2017 |
October 30, 2017 |
|
- Patras University Hospital
Rio, Achaia, Greece
|
| 18 |
NCT03293199 |
Recruiting |
Comparing Efficacy of Chest Tube Drainage and Needle Aspiration in Pneumothorax Treatment |
- Pneumothorax Spontaneous Primary
- Pneumothorax, Recurrent
- Pneumothorax Spontaneous Tension
- Pneumothorax, Spontaneous
|
- Procedure: Chest tube drainage
- Procedure: Repetitive needle aspiration
|
Interventional |
Not Applicable |
- Tabriz University of Medical Sciences
- AJA University of Medical Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pneumothorax recurrence during one-year
- Successful treatment rate
- Length of hospital admission
- (and 3 more...)
|
70 |
All |
18 Years and older (Adult, Senior) |
NCT03293199 |
IR.AJAUMS.REC.1396.24 |
|
August 12, 2017 |
July 12, 2018 |
October 12, 2018 |
September 26, 2017 |
September 26, 2017 |
|
- Imam Reza hospital
Tabriz, East Azerbaijan, Iran, Islamic Republic of
|
| 19 |
NCT03272815 |
Not yet recruiting |
Percussion Device (PD) for Detection of Pneumothorax |
|
- Device: Percussion Device (PD)
- Device: Ultrasound (US)
|
Interventional |
Not Applicable |
- Lawson Health Research Institute
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Performance metrics
- Inter-rater reliability
- Adverse Events
- Marginal Costs
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT03272815 |
109205 |
|
March 31, 2018 |
March 31, 2019 |
December 30, 2019 |
September 6, 2017 |
March 7, 2018 |
|
- London Health Sciences Centre
London, Ontario, Canada
|
| 20 |
NCT03260088 |
Not yet recruiting |
Evaluation Of Pleural Effusion At Assiut University Hospital |
|
- Diagnostic Test: Immunoglobulin G4
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- diagnosis new causes of previously remained undiagnosed cases of pleural effusion by using IgG4 in Assiut university hospital
|
1 |
All |
Child, Adult, Senior |
NCT03260088 |
PLEFF |
|
October 30, 2017 |
October 30, 2019 |
January 30, 2020 |
August 24, 2017 |
August 24, 2017 |
|
|
| 21 |
NCT03231072 |
Recruiting |
Pleural Effusion Drainage in Mechanically Ventilated Patients Monitored by EIT |
- Pleural Effusion
- Drainage
- Electric Impedance Tomography
|
- Device: Electrical Impedance Tomography record
|
Interventional |
Not Applicable |
- Czech Technical University in Prague
- Military University Hospital, Prague
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Change of the thorax electrical impedance following pleural effusion drainage in mechanically ventilated patients
- Change of the distribution of ventilation following pleural effusion drainage in mechanically ventilated patients
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT03231072 |
Ventilation-EIT-PE |
|
January 31, 2017 |
December 31, 2017 |
May 31, 2018 |
July 27, 2017 |
July 27, 2017 |
|
- The Military University Hospital
Prague, Czechia
|
| 22 |
NCT03227978 |
Not yet recruiting |
PCL (Poly-ε-caprolactone) Mesh Pleurodesis |
|
- Combination Product: PCL mesh pleurodesis
|
Interventional |
Early Phase 1 |
- National Taiwan University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- blood pressure and temperature
- pain scale
|
10 |
All |
18 Years to 50 Years (Adult) |
NCT03227978 |
1060006968 |
|
August 1, 2017 |
July 31, 2018 |
July 31, 2019 |
July 24, 2017 |
July 24, 2017 |
|
|
| 23 |
NCT03172052 |
Not yet recruiting |
Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital |
|
- Drug: streptokinase
- Drug: MESNA (2-mercaptoethane sulfonate Na)
- Device: Medical thoracoscopy
- Device: Video assisted thoracoscopy (VATS)
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- measurement of adhesiolysis success
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03172052 |
17200064 |
|
August 1, 2017 |
June 1, 2019 |
June 30, 2020 |
June 1, 2017 |
June 6, 2017 |
|
|
| 24 |
NCT03000504 |
Not yet recruiting |
Ballooned Intercostal Drain Trial |
- Pleural Effusion
- Pneumothorax
|
- Device: Ballooned intercostal drain
|
Interventional |
Phase 3 |
- Royal Brompton & Harefield NHS Foundation Trust
- Sherwood Forest Hospitals NHS Foundation Trust
- Oxford University Hospitals NHS Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The difference in the percentage of accidental removal of ICTs between study arms
- The difference in patient reported pain scores, using a visual analogue scale
- The frequency of balloon rupture
- (and 2 more...)
|
178 |
All |
18 Years and older (Adult, Senior) |
NCT03000504 |
217496 |
|
January 2018 |
June 2019 |
July 2019 |
December 22, 2016 |
November 9, 2017 |
|
- Sherwood Forest Hospitals NHS Foundation Trusty
Sutton in Ashfield, Nottinghamshire, United Kingdom - Oxford Respiratory Trials Unit
Oxford, Oxfordshire, United Kingdom - Royal Brompton Hospital
London, United Kingdom
|
| 25 |
NCT02907866 |
Recruiting |
Use of Endobronchial Ultrasound Scope (EBUS) Transducer to Identify Pneumothorax-A Feasibility Study |
|
- Device: Ultrasound with EBUS scope and with linear ultrasound probe
|
Observational |
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- The percentage of patients on whom a sliding sign and/or B lines are identified successfully with EBUS versus linear US
- Sensitivity, specificity, negative and positive predictive value of the bedside lung ultrasound using the EBUS transducer to detect pneumothorax as compared to the linear US, the bedside Chest X-ray and the final clinical diagnosis of pneumothorax.
- The Time elapsed between the end of the bronchoscopy and the completion of lung ultrasound will be compared to the time between the end of the bronchoscopy and the availability of CXR imaging.
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02907866 |
6622 |
|
September 2016 |
September 2017 |
September 2017 |
September 20, 2016 |
April 19, 2017 |
|
- Oklahoma University Medical center
Oklahoma City, Oklahoma, United States
|
| 26 |
NCT02851927 |
Recruiting |
Rigid vs Semirigid Thoracoscopy in Exudative Pleural Effusions |
|
- Procedure: Mini Thoracoscopy
- Procedure: SemiRigid Thoracoscopy
|
Interventional |
Not Applicable |
- All India Institute of Medical Sciences, New Delhi
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Diagnostic Yield
- Sedation dose
- Image quality
- (and 3 more...)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02851927 |
Mini vs Semirigid RCT |
|
June 2016 |
June 2018 |
September 2018 |
August 2, 2016 |
August 22, 2017 |
|
- All India Institute of Medical Sciences
New Delhi, India
|
| 27 |
NCT02840032 |
Recruiting |
Determination of Pneumothorax Post Lung Biopsy |
|
|
Observational |
|
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Determination of pneumothorax after transbronchial lung biopsy
|
100 |
All |
20 Years to 75 Years (Adult, Senior) |
NCT02840032 |
1606M88672 |
|
July 2016 |
August 2017 |
August 2017 |
July 21, 2016 |
July 29, 2016 |
|
- University of Minnesota
Minneapolis, Minnesota, United States
|
| 28 |
NCT02573285 |
Recruiting |
Spontaneous Pneumothorax in Children |
|
- Procedure: Simple Aspiration
- Procedure: Surgeon Preference
|
Interventional |
Not Applicable |
- University of Wisconsin, Madison
- Children's Hospital Medical Center, Cincinnati
- Indiana University
- (and 8 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The success rate of simple aspiration of initial management of primary spontaneous pneumothorax in children
- Rate of recurrent pneumothorax
- Time to recurrence of pneumothorax
- (and 5 more...)
|
80 |
All |
12 Years to 17 Years (Child) |
NCT02573285 |
2014-1188 |
|
September 2015 |
September 2018 |
July 2019 |
October 9, 2015 |
May 4, 2017 |
|
- American Family Children's Hospital
Madison, Wisconsin, United States
|
| 29 |
NCT02505763 |
Recruiting |
Thoracic Ultrasound in the Treatment of Pleural Effusion |
|
- Procedure: Strategy with thoracic ultrasound
|
Interventional |
Not Applicable |
- University Hospital, Toulouse
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The cost-effectiveness ration
- The duration of hospitalization
|
144 |
All |
18 Years and older (Adult, Senior) |
NCT02505763 |
14 7418 15 |
ECHOPLEV |
July 2015 |
July 2018 |
July 2019 |
July 22, 2015 |
July 22, 2015 |
|
- NOEL-SAVINA Elise
Toulouse, Midi Pyrenees, France
|
| 30 |
NCT02449980 |
Recruiting |
Primary Versus Delayed Surgical Therapy for Pediatric Spontaneous Pneumothorax |
|
- Procedure: Primary Surgery Group
- Procedure: Initial Non-operative management
|
Interventional |
Not Applicable |
- Baylor College of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Recurrence rate
- Postoperative complications
- Hospital Length of stay
- (and 2 more...)
|
56 |
All |
5 Years to 18 Years (Child, Adult) |
NCT02449980 |
H-32402 |
|
November 2016 |
November 2019 |
June 2020 |
May 21, 2015 |
January 23, 2018 |
|
- Texas Children's Hospital
Houston, Texas, United States
|
| 31 |
NCT02208895 |
Recruiting |
Correlation of In-lab Pleural Fluid Glucose Measurements With a Finger Stick Glucometer and Portable Point of Care Testing Device (i-STAT). |
|
|
Observational |
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Correlation of pleural fluid glucose measured with a glucometer and the I-STAT with the pleural fluid glucose level measured in the Lab
- Intra assay precision of pleural fluid glucose measured with a glucometer and with an I-STAT device.
|
30 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02208895 |
3785
VAMC OKC |
|
February 2014 |
November 2017 |
November 2017 |
August 5, 2014 |
March 17, 2017 |
|
- VAMC OKC
Oklahoma City, Oklahoma, United States
|
| 32 |
NCT02192138 |
Recruiting |
Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis |
- Pleural Effusion
- Exudative Pleuritis
|
- Procedure: Therapeutic thoracentesis
- Device: Pleural catheter
- Device: Pleural manometer
|
Interventional |
Not Applicable |
- Medical University of Warsaw
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in intrapleural pressure
- Intrapleural pressure
- Volume of withdrawn pleural fluid
|
60 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02192138 |
IPU-DIMPA-WUM14(1) |
|
April 2014 |
March 2018 |
June 2018 |
July 16, 2014 |
January 24, 2018 |
|
- Medical University of Warsaw
Warsaw, Poland
|
| 33 |
NCT02147821 |
Recruiting |
Necessity of Using Pleural Drainage Tubes After IMA Harvesting During Cardiac Surgery |
- Pleural Effusions Post Coronary Artery Bypass Graft
|
- Procedure: No Pleural Chest Tube
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pleural Effusion
- Postoperative Respiratory Status
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT02147821 |
REB13-1374 |
|
August 2014 |
December 2017 |
December 2017 |
May 28, 2014 |
November 6, 2017 |
|
- Foothills Medical Center
Calgary, Alberta, Canada
|
| 34 |
NCT02119169 |
Recruiting |
Pigtail Catheter: a Less Invasive Option for Pleural Drainage of Recurrent Hepatic Hydrothorax |
|
|
Interventional |
Not Applicable |
- Sherief Abd-Elsalam
- Tanta University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in chest radiography
- Chest X-ray and any complications recorded
|
30 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02119169 |
Mohamed Sharaf-Eldin
Tanta university hospital |
HH |
March 2014 |
December 2022 |
December 2022 |
April 21, 2014 |
December 27, 2017 |
|
- Tanta university hospital
Tanta, Egypt
|
| 35 |
NCT01994499 |
Recruiting |
Randomized Study Comparing Pleural Drainage by Videothoracoscopy to Medical Drainage in Infectious Pleural Effusion |
- Infectious Pleural Effusion
|
- Device: Videothoracoscopy drainage
- Drug: Medical drainage
|
Interventional |
Not Applicable |
- University Hospital, Rouen
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT01994499 |
2013/009/HP |
VIDMED |
January 2014 |
September 2017 |
October 2017 |
November 25, 2013 |
October 10, 2016 |
|
- University Hospital
Amiens, France - University Hospital
Caen, France - UH Rouen
Rouen, France
|
| 36 |
NCT01855464 |
Recruiting |
Wedge Resection or Parietal Pleurectomy for the Treatment of Recurrent Pneumothorax (WOPP) |
- Pneumothorax
- Recurrent Pneumothorax
|
- Procedure: wedge resection
- Procedure: parietal pleurectomy
|
Interventional |
Not Applicable |
- Wuerzburg University Hospital
- German Research Foundation
- German Federal Ministry of Education and Research
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Recurrence rate of primary pneumothorax following VAT surgery
- postoperative morbidity
- postoperative pain
- (and 2 more...)
|
360 |
All |
15 Years to 40 Years (Child, Adult) |
NCT01855464 |
UKW-TCH-2013-001
German Research Foundation |
WOPP |
November 2013 |
November 2019 |
May 2020 |
May 16, 2013 |
May 3, 2017 |
|
- Charité
Berlin, Germany - Vivantes Thoraxzentrum
Berlin, Germany - Evangelische Lungenklinik Berlin
Berlin, Germany - (and 20 more...)
|
| 37 |
NCT01848860 |
Recruiting |
Absorbable Mesh Pleurodesis in Thoracoscopic Treatment of Spontaneous Pneumothorax |
- Spontaneous Pneumothorax
- Surgery
|
- Procedure: Thoracoscopic bullectomy and pleural abrasion
- Biological: Mesh coverage of the staple line
|
Interventional |
Phase 2
Phase 3 |
- National Taiwan University Hospital
- National Science Council, Taiwan
- Chang Gung Memorial Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- the rates of ipsilateral pneumothorax recurrence
- Safety of mesh coverage
- long-term safety of mesh coverage
|
204 |
All |
15 Years to 50 Years (Child, Adult) |
NCT01848860 |
201211051DIC |
|
May 2013 |
December 2018 |
December 2018 |
May 8, 2013 |
July 8, 2015 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
| 38 |
NCT00530725 |
Recruiting |
Management of Occult Pneumothoraces in Mechanically Ventilated Patients |
|
- Procedure: chest drainage
- Other: close clinical observation
|
Interventional |
Not Applicable |
- University of Calgary
- CHU de Quebec-Universite Laval
- Sunnybrook Health Sciences Centre
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Outcome Variables: In ventilated patients with small to moderate sized occult PTXs, the rate of respiratory distress will not differ between those treated with chest thoracostomy tubes and those not treated but simply observed
- Observation of small OPTXs in ventilated patients will not increases the rates of Emergency chest drainage, Death, tracheostomy, ARDS, Ventilator associated pneumonia (VAP), or the Abdominal Compartment Syndrome (ACS)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT00530725 |
OPTICC Trial |
OPTICC |
August 2006 |
December 2018 |
June 2020 |
September 17, 2007 |
October 26, 2017 |
|
- Foothills Medical Centre
Calgary, Alberta, Canada - Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada - Centre Hospitalier Affilie Universitaire de Quebec
Quebec City, Quebec, Canada - University of Sherbrooke
Sherbrooke, Canada
|
| 39 |
NCT03034421 |
Recruiting |
Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema |
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Advent of pneumothorax within 90 days following valve implantation
- Lung function before and after valve therapy
- Excercise capacity before and after valve therapy
- Dyspnoe score before and after valve therapy
|
130 |
All |
30 Years and older (Adult, Senior) |
NCT03034421 |
Protocol G1.1 - 17.04.2016 |
|
September 2016 |
November 2017 |
January 2018 |
January 27, 2017 |
January 27, 2017 |
|
- Thoraxklinik Heidelberg
Heidelberg, Germany
|
| 40 |
NCT03501524 |
Recruiting
New |
VATS Evacuation Compared to Reinsertion of Thoracostomy Tube in Persistent Traumatic Haemothorax |
|
- Device: VATS evacuation
- Device: thoracostomy tube
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Duration of hospitalization
- number of patients developed empyema
|
2 |
All |
18 Years to 60 Years (Adult) |
NCT03501524 |
17100227 |
|
July 1, 2017 |
July 30, 2018 |
July 30, 2018 |
April 18, 2018 |
April 18, 2018 |
|
- Assiut university
Assiut, Egypt
|
| 41 |
NCT03189654 |
Recruiting |
Noninvasive Ventilation Therapy for the Treatment of Pleural Effusion in Patients With Heart Failure |
- Pleural Effusion
- Heart Failure
|
- Device: Non-invasive ventilation
|
Observational |
|
- Heart and Diabetes Center North-Rhine Westfalia
- ResMed GmbH & Co KG
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Amount of pleural effusion
- nt-Pro-BNP
- Cardiac output
- NYHA class
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03189654 |
HDZNRW-KA_010_TB |
|
July 1, 2017 |
April 2018 |
December 2018 |
June 16, 2017 |
July 24, 2017 |
|
- Clinic for Cardiology, Herz- und Diabeteszentrum NRW, Ruhr-Universität Bochum
Bad Oeynhausen, Germany
|
| 42 |
NCT03093610 |
Not yet recruiting |
Evaluation of Fluid Output Threshold for Safe Chest Tube Removal - A Potential Way to Decrease Length of Stay in Hospital and to Improve Postoperative Care After Lung Surgery? |
- Pleural Effusion Recurrence
- Pulmonary Resection
- Chest Tube Management
|
- Procedure: Traditional
- Procedure: Test
|
Interventional |
Not Applicable |
- University Hospital Inselspital, Berne
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Prevention
|
- Number of recurrent pleural effusions after chest tube removal
- Pain scores (VAS-Score)
- Time Point of chest tube removal
- Patient discharge
|
304 |
All |
18 Years and older (Adult, Senior) |
NCT03093610 |
14032017 |
|
June 1, 2017 |
March 31, 2019 |
March 31, 2020 |
March 28, 2017 |
May 3, 2017 |
|
- Bern University Hospital
Bern, Switzerland
|
| 43 |
NCT02558608 |
Recruiting |
Effect of Dissecting of The Inferior Pulmonary Ligament on Postoperative Pulmonary Reexpansion and Recurrence |
|
- Procedure: DIPL
- Procedure: WR
- Procedure: thoracoscopic surgery
|
Interventional |
Phase 3 |
- Chinese Medical Association
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- recurrence rate
- pulmonary reexpansion rate
|
260 |
All |
10 Years to 50 Years (Child, Adult) |
NCT02558608 |
FPL001 |
|
June 2015 |
December 2018 |
April 2020 |
September 24, 2015 |
October 16, 2015 |
|
- Beijing Haidian Hospital
Beijing, Beijing, China
|
| 44 |
NCT03050502 |
Not yet recruiting |
The Management of Traumatic Hemothoraces |
- Hemothorax
- Thoracic Injuries
|
- Device: Chest tube drain
- Other: Expectant management
|
Interventional |
Not Applicable |
- University of Calgary
- Alberta Health Services
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The numbers of hemothoraces that require thoracic interventions.
- The days of mechanical ventilation in intensive care unit
- The days of intensive care unit stay
|
200 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT03050502 |
REB16-1056 |
HemoTxRCT |
February 2018 |
March 2020 |
December 2020 |
February 13, 2017 |
October 31, 2017 |
|
- Foothills Medical Centre, Faculty of Medicine
Calgary, Alberta, Canada
|
| 45 |
NCT02916992 |
Recruiting |
Prevalence of Spontaneous Pneumothorax in BHD |
|
- Radiation: CT scan of the thorax
- Genetic: blood sample for FLCN mutation analyses
|
Interventional |
Phase 1 |
- Hans Smit
- Prof. Dr. Jaap Swieringa stichting
- Mr. Willem Bakhuys Roozeboomstichting
- (and 2 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- presence of pathogenic FLCN mutations
- presence of lung cysts
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT02916992 |
2014-0525
50605
2014-1386
NL50605.091.14 |
|
September 2016 |
June 2017 |
July 2017 |
September 28, 2016 |
October 26, 2016 |
|
- Rijnstate
Arnhem, Gelderland, Netherlands
|
| 46 |
NCT02771184 |
Recruiting |
Computerized Lung Sound Analysis |
- Pneumothorax
- Pulmonary Fibrosis
|
- Device: Lung Sound Recording System
|
Interventional |
Not Applicable |
- Smolle-Juettner Freyja, Prof MD
- Graz University of Technology
- Medical University of Graz
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- 16-Channel Lung Sound Recordings and synchronous Airflow Recording
|
56 |
All |
18 Years and older (Adult, Senior) |
NCT02771184 |
28-088 ex 15/16 |
CLSA |
April 2016 |
July 2018 |
July 2018 |
May 13, 2016 |
February 5, 2018 |
|
- Medical University of Graz
Graz, Austria
|
| 47 |
NCT03098524 |
Recruiting |
Low Tidal MEChanical Ventilation Against NO Ventilation During Cardiopulmonary Bypass Heart Surgery |
- Respiratory Failure
- Atelectasis
- Pneumonia
- (and 4 more...)
|
- Procedure: Low tidal volume ventilation (LTV arm)
- Procedure: No ventilation (noV arm)
- Procedure: Lung recruitment manoeuver
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- All-cause mortality or early respiratory failure or Late respiratory failure or Ventilator acquired pneumonia and early pneumonia
- All-cause in-hospital mortality
- Early respiratory failure
- (and 5 more...)
|
1500 |
All |
18 Years and older (Adult, Senior) |
NCT03098524 |
2016/03 |
MECANO |
May 1, 2017 |
April 15, 2020 |
April 15, 2020 |
March 31, 2017 |
July 6, 2017 |
|
- CMC Ambroise Paré
Neuilly-sur-Seine, Ile-de-France, France
|
| 48 |
NCT03482570 |
Recruiting
New |
Activity Behaviours in Patients With Malignant Pleural Effusion |
- Malignant Pleural Effusion
|
|
Observational |
|
- The University of Hong Kong
- The University of Western Australia
- Edith Cowan University, Australia
- (and 3 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Activity Behaviours (vertical axis movement counts per min)
- Quality of life (in mm)
- Respiratory symptoms (in mm)
- Survival (in number of days)
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT03482570 |
HKU_UW_17_516 |
|
January 31, 2018 |
December 31, 2019 |
December 31, 2020 |
March 29, 2018 |
April 2, 2018 |
|
- University of Hong Kong Queen Mary Hospital
Hong Kong, Hong Kong
|
| 49 |
NCT03414905 |
Not yet recruiting |
Management of Malignant Pleural Effusions Using an Indwelling Tunneled Pleural Catheter and Non-Vacuum Collection System |
- Malignant Pleural Effusion
|
- Device: Aspira Catheter
- Procedure: Ultrasound
|
Interventional |
Phase 1 |
- Washington University School of Medicine
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Relief of dyspnea as measured using the Visual Analog Scale for Dyspnea (VAS-Dyspnea)
- Rate of infection
- Rate of spontaneous pleurodesis
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03414905 |
201708040 |
|
May 31, 2018 |
June 30, 2019 |
March 31, 2020 |
January 30, 2018 |
March 16, 2018 |
|
- Washington University School of Medicine
Saint Louis, Missouri, United States
|
| 50 |
NCT03403855 |
Not yet recruiting |
Rocket® Pleural Catheters: QOL, Feasibility and Satisfaction in Recurrent MPE Patients |
- Malignant Pleural Effusion
|
- Device: Rocket® IPC- Long External Length
- Device: Rocket® IPC- Short External Length
|
Interventional |
Not Applicable |
- Ottawa Hospital Research Institute
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patients' self-rated quality of life - change from baseline compared to 2 and 4 weeks post catheter insertion.
- Patients' self-rated quality of life on domains specific to lung cancer-change from baseline compared to 2 and 4 weeks post catheter insertion.
- Ease of use of the short versus long Rocket® pleural catheter.
- Feasibility: measured by incidence of complications (adverse events reports)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03403855 |
20170753-01H |
|
January 20, 2018 |
December 30, 2019 |
December 30, 2020 |
January 19, 2018 |
January 19, 2018 |
|
- Ottawa Hospital, General Campus
Ottawa, Ontario, Canada
|
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