| 1 |
NCT02430766 |
Recruiting |
Irreversible Electroporation(IRE) For Unresectable Lymph Node Metastases(Close to Nerve) |
|
- Procedure: Irreversible electroporation (IRE)
- Device: NanoKnife
|
Interventional |
Phase 1
Phase 2 |
- Fuda Cancer Hospital, Guangzhou
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with Adverse events
- Percentage of lesions that show no sign of recurrence 12 months after IRE
- A minimum and maximum range of voltage for safe and effective IRE
- (and 2 more...)
|
30 |
All |
Child, Adult, Senior |
NCT02430766 |
lymphnode metastases-IRE-01 |
IRE |
January 2015 |
January 2017 |
January 2020 |
April 30, 2015 |
March 29, 2016 |
|
- Biological treatment center in Fuda cancer hospital
Guangzhou, Guangdong, China
|
| 2 |
NCT03474926 |
Recruiting
New |
Prognostic Value of Lymph Node Dissection in Patients With Transitional Cell Carcinoma of the Upper Urinary Tract |
|
- Procedure: Routine Template-based lymphadenectomy
- Procedure: LND only for lymph nodes enlargement in preoperative image
|
Interventional |
Phase 2 |
- RenJi Hospital
- Peking University First Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Disease free survival
- Cancer specific survival
- Overall survival
- (and 2 more...)
|
504 |
All |
15 Years to 80 Years (Child, Adult, Senior) |
NCT03474926 |
UTUC-LND collaboration 1 |
|
February 22, 2018 |
February 22, 2023 |
February 22, 2023 |
March 23, 2018 |
March 23, 2018 |
|
- Peking University First Hospital
Beijin, Beijin, China - Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai, China
|
| 3 |
NCT02984787 |
Not yet recruiting |
3D Versus 2D Laparoscopic Total Gastrectomy With Splenic Hilum Lymph Nodes Dissection |
- Splenic Hilum Lymph Nodes Dissection
|
- Procedure: 3D Laparoscopic total gastrectomy
- Procedure: 2D Laparoscopic total gastrectomy
|
Interventional |
Phase 3 |
- Chinese PLA General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of splenic hilum lymph nodes harvested
- Early complication rate
- Operative time
- (and 7 more...)
|
480 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02984787 |
Experiment20161201 |
|
January 2017 |
December 2019 |
January 2020 |
December 7, 2016 |
December 7, 2016 |
|
- Chinese PLA General Hospital
Beijing, China
|
| 4 |
NCT03222895 |
Not yet recruiting |
Distribution of Lymph Node Metastases in Esophageal Carcinoma |
- Esophageal Neoplasms
- Lymph Node Metastases
|
|
Observational |
|
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Distribution of lymph node metastases
- Accuracy of preoperative diagnostics
- Prognostic value of different lymph node stations
- (and 5 more...)
|
5000 |
All |
18 Years and older (Adult, Senior) |
NCT03222895 |
W17_069 |
TIGER |
March 1, 2018 |
September 2019 |
September 2024 |
July 19, 2017 |
January 30, 2018 |
|
|
| 5 |
NCT03223064 |
Recruiting |
Accuracy of Lymph Node Imaging in Prostate Cancer: PSMA PET-CT and Nano-MRI |
- Prostate Cancer
- Lymph Node Metastases
|
- Diagnostic Test: Ferumoxtran-10 enhanced MRI; MRI contrast agent
- Diagnostic Test: 68Ga PSMA PET-CT
|
Interventional |
Not Applicable |
- Radboud University
- Astellas Pharma Inc
- Canisius-Wilhelmina Hospital
- Catharina Ziekenhuis Eindhoven
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Concordance between and sensitivity and specificity of PSMA PET-CT and USPIO enhanced MRI
|
40 |
Male |
Child, Adult, Senior |
NCT03223064 |
ASTELLAS/MAGNIFY |
MAGNIFY |
December 30, 2016 |
December 31, 2017 |
December 31, 2017 |
July 19, 2017 |
July 21, 2017 |
|
- Radboud University Medical Centre
Nijmegen, Gelderland, Netherlands - Catharina Ziekenhuis Eindhoven
Eindhoven, Netherlands - Canisius Wilhelmina Ziekenhuis
Nijmegen, Netherlands
|
| 6 |
NCT03200704 |
Not yet recruiting |
A Study Assessing the Safety and Utility of IC2000 and SPY Fluorescence Imaging Systems in the Identification of Lymph Nodes During Lymphatic Mapping in Subjects With Breast Cancer |
- Breast Cancer
- Lymph Node Mapping
|
- Combination Product: IC2000 and SPY-PHI
|
Interventional |
Phase 3 |
- Novadaq Technologies Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The proportion of lymph nodes identified by IC2000 and SPY-PHI will be compared to the proportion of lymph nodes identified by Isosulfan Blue.
- The proportion of subjects in which at least one lymph node identified by IC2000 and SPY-PHI will be compared to the proportion of subjects with at least one lymph node identified by Isosulfan Blue.
- The proportion of subjects with at least one lymphatic vessel identified by IC2000 and SPY-PHI will be compared to the proportion of subjects with at least one lymphatic vessel identified by Isosulfan Blue.
- (and 2 more...)
|
110 |
Female |
18 Years and older (Adult, Senior) |
NCT03200704 |
SPY LNM 01 |
FILM-B |
June 2018 |
June 2019 |
October 2019 |
June 27, 2017 |
February 6, 2018 |
|
|
| 7 |
NCT03199560 |
Recruiting |
Tilmanocept vs Sulfur Colloid in Sentinel Lymph Node Biopsy |
- Sentinel Lymph Node Biopsy
- Breast Cancer
|
- Drug: Tc 99m tilmanocept
- Drug: Tc 99m filtered sulfur colloid
|
Interventional |
Phase 4 |
- Memorial Health University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Diagnostic
|
- Number of harvested lymph nodes
|
86 |
Female |
18 Years and older (Adult, Senior) |
NCT03199560 |
2016.12.1 |
|
June 22, 2017 |
June 22, 2019 |
August 22, 2019 |
June 27, 2017 |
June 27, 2017 |
|
- Memorial Health University Medical Center
Savannah, Georgia, United States
|
| 8 |
NCT03322826 |
Recruiting |
Systematic Sampling of Lymph Nodes vs. Lymphadenectomy According to Intraoperative Frozen Pathology for Pulmonary Invasive Adenocarcinoma With Ground-glass Opacity |
|
- Procedure: systematic sampling of the lymph-node
- Procedure: lymphadenectomy
|
Interventional |
Not Applicable |
- Shanghai Pulmonary Hospital, Shanghai, China
- Changhai Hospital
- Shanghai 10th People's Hospital
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- recurrence-free survival
- Overall Survival
- Morbidity rate
- Mortality rate
|
600 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03322826 |
SHDC12015116 |
|
December 8, 2017 |
October 28, 2021 |
October 28, 2023 |
October 26, 2017 |
December 19, 2017 |
|
- Shanghai Pulmonary Hospital
Shanghai, Shanghai, China
|
| 9 |
NCT02876874 |
Recruiting |
Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage |
- Rheumatoid Arthritis
- Lymph Node Mass
- Lymphatic Vessel; Dilatation
|
- Drug: indocyanine green(ICG)
|
Observational |
|
- Shanghai University of Traditional Chinese Medicine
|
Other |
- Time Perspective: Prospective
|
- T-initial
- S-max
- T-max
- (and 10 more...)
|
21 |
All |
18 Years to 65 Years (Adult) |
NCT02876874 |
RA and lymphatic vessels |
|
December 2014 |
December 2017 |
December 2018 |
August 24, 2016 |
August 24, 2016 |
|
- Longhua Hospital, Shanghai University of TCM
Shanghai, Shanghai, China - Longhua Hospital, Shanghai University of TCM
Shanghai, China
|
| 10 |
NCT03065244 |
Recruiting |
KIDCARE (Kawasaki Disease Comparative Effectiveness Trial) |
- Mucocutaneous Lymph Node Syndrome
|
- Drug: IVIG
- Drug: Infliximab
|
Interventional |
Phase 3 |
- University of California, San Diego
- Patient-Centered Outcomes Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Cessation of fever within 24h of initiation of study treatment with no fever recurrence within next 7 days.
- Cessation of fever within 24h following completion of treatment infusion (Length of infusion is 2h for infliximab and 8-10h for second IVIG)
- Change in white blood cell count (WBC), absolute neutrophil count (ANC), and high-sensitivity C-reactive protein (hsCRP, mg/L) concentration between baseline and 24 hours and 2 weeks following study treatment.
- (and 4 more...)
|
250 |
All |
up to 17 Years (Child) |
NCT03065244 |
UCSD 170064 |
KIDCARE |
February 17, 2017 |
January 2020 |
September 2020 |
February 27, 2017 |
February 27, 2017 |
|
- University of California San Diego
La Jolla, California, United States
|
| 11 |
NCT02982148 |
Recruiting |
Methylene Blue Intradermal Injection for Sentinel Lymph Node Biopsy for Breast Cancer Patients |
- Breast Cancer Female
- Early-Stage Breast Cancer
- Sentinel Lymph Node
|
- Device: methylene blue intradermal injection
- Device: methylene blue subcutaneous injection
|
Interventional |
Phase 4 |
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- detective rate of sentinel lymph node
- detective rate of blue lymphatic
- incidence of adverse events
|
352 |
Female |
18 Years to 65 Years (Adult) |
NCT02982148 |
SLNB5010 |
|
May 2015 |
January 2017 |
January 2017 |
December 5, 2016 |
December 5, 2016 |
|
- Sun-Yat-Sen Memorial Hospital of Sun-Yat-Sen University
Guangzhou, Guangdong, China
|
| 12 |
NCT02861430 |
Recruiting |
Ex-vivo Sentinel Lymph Node in Stage I-II Colon Cancer: Kappa Analysis With Immunochemistry and Molecular Biology |
- Colon Cancer
- Lymph Node
- Sentinel Node
|
- Procedure: Immunochemistry and molecular biology on sentinel lymph node specimen
|
Observational |
|
- Centre Hospitalier Universitaire de Besancon
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Concordance between immunochemistry and molecular biology
- Disease-free survival
|
388 |
All |
18 Years and older (Adult, Senior) |
NCT02861430 |
Besancon Unmask |
UNMASK |
April 2014 |
April 2017 |
March 2020 |
August 10, 2016 |
August 10, 2016 |
|
- CHRU Besancon
Besancon, France
|
| 13 |
NCT03416803 |
Recruiting |
A Study of Individualized Radiotherapy Based on a Prediction Model of Lymph Node Metastasis in Hepatocellular Carcinoma |
- Lymph Node Metastasis
- Hepatocellular Carcinoma
- Radiotherapy
|
|
Interventional |
Not Applicable |
- Shanghai Zhongshan Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Prevention
|
|
150 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03416803 |
ZS-LNM-2017 |
|
February 2018 |
December 31, 2019 |
June 30, 2020 |
January 31, 2018 |
February 2, 2018 |
|
- 180 Fenglin Road
Shanghai, China
|
| 14 |
NCT03478449 |
Not yet recruiting
New |
The Criteria for Lymph Node Sorting for Pathological Examination in Gastric Cancer |
- Lymph Node Metastases
- Gastric Cancer
- Exanimation
|
- Procedure: lymph node sorting for pathological examination
|
Interventional |
Not Applicable |
- Tianjin Medical University Cancer Institute and Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Participant)
- Primary Purpose: Diagnostic
|
- Migration of pN stage in gastric cancer patients
|
276 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03478449 |
DJY001 |
|
May 1, 2018 |
April 30, 2020 |
June 30, 2020 |
March 27, 2018 |
March 27, 2018 |
|
|
| 15 |
NCT02166788 |
Recruiting |
Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma |
- Metastatic Melanoma to the Groin Lymph Nodes
|
- Procedure: Inguinal Lymphadenectomy
- Procedure: Ilio-inguinal Lymphadenectomy
|
Interventional |
Phase 3 |
- Australia and New Zealand Melanoma Trials Group
- Cancer Council New South Wales
- Melanoma Institute Australia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary endpoint of the study will be Disease Free Survival following lymphadenectomy, assessed after 60 months of follow-up.
- Overall Survival
- Distant Disease Free Survival
- (and 5 more...)
|
634 |
All |
15 Years and older (Child, Adult, Senior) |
NCT02166788 |
ANZMTG 01.12 |
EAGLE FM |
January 2015 |
August 2025 |
August 2030 |
June 18, 2014 |
November 9, 2017 |
|
- Calvary Public Hospital Bruce
Canberra, Australian Capital Territory, Australia - Melanoma Institute Australia - The Poche Centre
North Sydney, New South Wales, Australia - Sydney Adventist Hospital
Sydney, New South Wales, Australia - (and 11 more...)
|
| 16 |
NCT03280719 |
Recruiting |
Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions |
- Breast Neoplasms
- Radiotherapy
- Lymph Node Metastases
|
- Device: Prone Radiotherapy
- Radiation: Acceleration
- Device: Supine Radiotherapy
- Radiation: Hypofractionation
|
Interventional |
Not Applicable |
- University Ghent
- University Hospital, Ghent
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Breast retraction
- Acute toxicity - Dermatitis
- Acute toxicity - Desquamation
- (and 26 more...)
|
388 |
Female |
18 Years and older (Adult, Senior) |
NCT03280719 |
EC/2017/0256
CIV-BE-17-06-020245 |
PRO-SURF |
September 15, 2017 |
August 2022 |
August 2025 |
September 12, 2017 |
December 27, 2017 |
|
- Radiotherapy department, UZ Ghent
Ghent, Oost-Vlaanderen, Belgium
|
| 17 |
NCT02939066 |
Recruiting |
Endoscopic Ultrasound-guided Needle-based Confocal Laser Endomicroscopy for Evaluation of Malignant Lymph Nodes - a Pilot Study |
- Malignancy or Benign of Enlarged Lymph Nodes
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The nCLE interpretation criteria for the characterization of malignant lymph nodes
|
30 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02939066 |
2016SDU-QILU-22 |
|
May 2016 |
December 2017 |
|
October 19, 2016 |
February 16, 2017 |
|
- Department of Gastroenterology, Qilu Hospital, Shandong University
Jinan, Shandong, China
|
| 18 |
NCT01886066 |
Recruiting |
Accuracy of Sentinel Lymph Node Biopsy in Nodal Staging of High Risk Endometrial Cancer |
- Endometrial Cancer
- Sentinel Lymph Node
- Indocyanine Green
|
- Biological: Indocyanine Green (ICG)
|
Interventional |
Not Applicable |
- University Health Network, Toronto
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
|
60 |
Female |
18 Years and older (Adult, Senior) |
NCT01886066 |
12-0257-C |
EndoSLN |
March 2012 |
June 2018 |
June 2018 |
June 25, 2013 |
April 7, 2017 |
|
- Sunnybrook Health Sciences Center
Toronto, Ontario, Canada - University Health Network - Princess Margaret Hospital
Toronto, Ontario, Canada
|
| 19 |
NCT02711033 |
Recruiting |
Laparoscopic-assisted Total Gastrectomy Versus Open Total Gastrectomy With Splenic Hilum Lymph Nodes Dissection |
- Gastric Cancer
- Splenic Hilum Lymph Nodes Dissection
- Total Gastrectomy
|
- Procedure: Laparoscopic-assisted total gastrectomy
- Procedure: Open total gastrectomy
|
Interventional |
Phase 2 |
- Guangdong Provincial Hospital of Traditional Chinese Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Early complication rate
- Operative time
- Time of splenic hilum lymph nodes dissection
- (and 9 more...)
|
144 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02711033 |
GDPHCM-GI-01 |
|
October 2015 |
October 2018 |
April 2019 |
March 17, 2016 |
April 10, 2017 |
|
- Guangdong Province Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
|
| 20 |
NCT00964977 |
Recruiting |
Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis. |
- Oropharyngeal Cancer
- Oral Cancer
- Lymph Node Metastasis
|
- Radiation: Radiation therapy
|
Interventional |
Phase 3 |
- Johannes Gutenberg University Mainz
- Deutsche Krebshilfe e.V., Bonn (Germany)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Primary study object: overall survival
- Time to occurrence of local relapse
- Time to lymphatic metastasis
- (and 2 more...)
|
560 |
All |
18 Years and older (Adult, Senior) |
NCT00964977 |
DOESAK-pN1-108399 |
|
October 2009 |
December 2013 |
December 2018 |
August 25, 2009 |
November 16, 2012 |
|
- Universiätsklinikum Tübingen
Tübingen, Baden Württemberg, Germany - Universitätsklinikum Erlangen
Erlangen, Bayern, Germany - Universitätsklinik München
München, Bayern, Germany - (and 46 more...)
|
| 21 |
NCT03230201 |
Recruiting |
Lymph Node Dissection in High-risk UTUC(Upper Tract Urothelial Carcinoma) |
- Recurrence
- Metastasis
- Upper Tract Urothelial Carcinoma
- Lymph Node Dissection
|
- Procedure: Lymph node dissection
|
Interventional |
Not Applicable |
- Peking University First Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- overall survival
- postoperative morbidity and mortality
- recurrence-free survival
- (and 2 more...)
|
80 |
All |
Child, Adult, Senior |
NCT03230201 |
IUPU-16-UTUC-3 |
UTUC |
January 1, 2017 |
January 1, 2021 |
January 1, 2021 |
July 26, 2017 |
August 8, 2017 |
|
- Peking University First Hospital
Beijing, Beijing, China
|
| 22 |
NCT03470259 |
Not yet recruiting |
Precision Thyroid Cancer Surgery With Intraoperative Molecular Fluorescent Guided Imaging |
- Papillary Thyroid Cancer
- Lymph Node Metastases
|
- Drug: IV adminstration of EMI-137
- Device: Multispectral Fluorescence Reflectance Imaging
|
Interventional |
Phase 1 |
- University Medical Center Groningen
- UMC Utrecht
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- The feasibility of Molecular Fluorescence Guided Surgery using EMI-137
- Safety of using EMI-137 through monitoring vital signs
- Safety of using EMI-137 through monitoring injection site
- (and 6 more...)
|
32 |
All |
18 Years and older (Adult, Senior) |
NCT03470259 |
NL62817.042.17 |
TARGET |
April 2018 |
October 2019 |
April 2020 |
March 19, 2018 |
March 30, 2018 |
|
- University Medical Center Groningen
Groningen, Netherlands
|
| 23 |
NCT03452982 |
Not yet recruiting |
Sentinel Lymph Node in Early Ovarian Cancer |
|
- Other: sentinel node technique
|
Interventional |
Phase 2 |
- Instituto de Investigacion Sanitaria La Fe
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Feasibility of performing the sentinel node technique (Detection rate)
- Rate of realization of the technique
- Anatomical location of the sentinel node(s)
- (and 5 more...)
|
20 |
Female |
18 Years and older (Adult, Senior) |
NCT03452982 |
SENTOV |
SENTOV |
March 2018 |
March 2019 |
March 2019 |
March 2, 2018 |
March 2, 2018 |
|
|
| 24 |
NCT03073096 |
Recruiting |
LYMPHA: Eliminating the Burden of Lymphedema in Patients Requiring Nodal Dissection |
|
- Procedure: LVA at time of nodal dissection
|
Interventional |
Not Applicable |
- Ottawa Hospital Research Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Difference in limb volume between surgery-affected and surgery-unaffected limb at baseline, 3, 6, 9, 12 and 24 months
- Limb-lymphedema-specific Quality of life assessment at baseline, 3, 6, 9, 12 and 24 months through the LYMQOL questionnaire
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03073096 |
20170146 form 6131 |
|
June 1, 2017 |
September 1, 2018 |
September 1, 2019 |
March 8, 2017 |
September 21, 2017 |
|
- The Ottawa Hospital
Ottawa, Ontario, Canada
|
| 25 |
NCT03097575 |
Recruiting |
Bronchial NIR Image-guided Resection |
|
- Drug: ICG Intervention
- Device: Near Infrared Imaging
|
Interventional |
Phase 1
Phase 2 |
- Brigham and Women's Hospital
- Society of University Surgeons
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Incidence of treatment-emergent adverse events (safety and feasibility) of intraoperative NIR-image-guided localization of lung lesions using peritumoral ICG injection.
- Investigate whether SLNs can be identified using NIR-guidance following peritumoral ICG injection.
- Assess if NIR image-guided SLN excision enhances detection of metastatic disease and whether the presence of untreated occult metastatic disease/mutational analysis of primary tumors/secondary sites of disease including SLNs are predictors of outcome
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03097575 |
2014P001436 |
|
January 6, 2015 |
January 1, 2020 |
January 1, 2021 |
March 31, 2017 |
January 18, 2018 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States
|
| 26 |
NCT02690259 |
Recruiting |
Sentinel Lymph Node Detection in Endometrial Cancer |
|
- Procedure: Sentinel node procedure
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Detection of sentinel nodes
- Detection of Sentinel nodes
- Detection of Setinel nodes
- (and 2 more...)
|
375 |
Female |
18 Years and older (Adult, Senior) |
NCT02690259 |
RegionSkaneKKLund |
|
June 2014 |
June 2019 |
June 2021 |
February 24, 2016 |
September 5, 2017 |
|
- Department of Gynecology and Obstetrics
Lund, Sweden
|
| 27 |
NCT03442543 |
Recruiting |
Preoperative Localization of Sentinel Lymph Node in Breast Cancer Patients By Novel Computed Tomography-Lymphography Guided Technique |
|
- Device: preoperative localization of SLN detected by CTLG by either methods
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Diagnostic
|
- detection of the sentinel lymph node by the novel method & matching between the sentinel lymph node detected by the novel method and the control one
|
50 |
All |
Child, Adult, Senior |
NCT03442543 |
MD/17.03.68 |
|
July 2, 2017 |
July 1, 2018 |
March 1, 2019 |
February 22, 2018 |
February 23, 2018 |
|
- Oncology center, Mansoura University
Mansourah, Egypt
|
| 28 |
NCT02570399 |
Recruiting |
High Dose SBRT for Abdominal-Pelvic Lymph Nodal Lesions in Oligometastatic Patients |
- Lymph Node Cancer Metastatic
|
- Radiation: Oligometastatic patients with abdominal-pelvic lymph nodes
|
Interventional |
Not Applicable |
- Istituto Clinico Humanitas
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Feasibility in terms of toxicity related to radiation therapy
- Tumour response to local radiation therapy (RECIST criteria)
- Overall survival in the oligometastatic patients
- (and 2 more...)
|
39 |
All |
18 Years and older (Adult, Senior) |
NCT02570399 |
1388 |
|
April 2015 |
April 2018 |
April 2022 |
October 7, 2015 |
October 7, 2015 |
|
- Istituto Clinico Humanitas
Rozzano, Milano, Italy
|
| 29 |
NCT01134523 |
Recruiting |
Regimens Comparison for Breast Cancers of Positive Lymph Nodes |
|
- Drug: Epirubicin, CTX, Paclitaxel
- Drug: Epirubicin, Paclitaxel
|
Interventional |
Phase 3 |
- Chinese Academy of Medical Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
1000 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT01134523 |
CH-BC-006 |
|
May 2010 |
May 2018 |
May 2020 |
June 2, 2010 |
March 15, 2013 |
|
- Cancer Institute & Hospital. Chinese Academy of Medical Sciences
Beijing, China
|
| 30 |
NCT03264807 |
Recruiting |
Lymph Node 14v Dissection in Clinical Stage T3N+, T4N+ of Gastric Cancer |
|
- Procedure: D2 lymphadenectomy
- Procedure: D2 and #14v lymphadenectomy
|
Interventional |
Phase 3 |
- National Cancer Center, Korea
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Superiority verification of disease-free survival after lymphadenectomy for D2 + 14v lymph node dissection in gastric resection in patients with T3N + and T4N + stomach cancer
|
518 |
All |
19 Years and older (Adult, Senior) |
NCT03264807 |
NCC2015-0188 |
|
August 6, 2015 |
December 30, 2020 |
December 31, 2021 |
August 29, 2017 |
August 29, 2017 |
|
- The Catholic University of Korea, Incheon St. Mary'S Hospital
Incheon, Bupyeong-gu, Korea, Republic of - Dankook University Hospital
Chungcheong, Cheonan-si, Korea, Republic of - Dongnam Inst. of Radiological & Medical Sciences
Busan, Gijang-gun, Korea, Republic of - (and 7 more...)
|
| 31 |
NCT03255577 |
Recruiting |
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy For Locally Advanced Breast Cancer |
- Breast Cancer
- Locally Advanced Breast Cancer
|
- Procedure: Sentinel Lymph Node Biopsy (SLNB)
|
Interventional |
Not Applicable |
- Memorial Sloan Kettering Cancer Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The false negative rate of sentinel lymph node biopsy in patients with locally advanced breast cancer
|
100 |
Female |
18 Years and older (Adult, Senior) |
NCT03255577 |
17-384 |
|
August 17, 2017 |
August 2020 |
August 2020 |
August 21, 2017 |
December 4, 2017 |
|
- Memorial Sloan Kettering at Basking Ridge
Basking Ridge, New Jersey, United States - Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States - Memorial Sloan Kettering Commack
Commack, New York, United States - (and 3 more...)
|
| 32 |
NCT02448953 |
Recruiting |
Two-field Versus Three-field Lymphadenectomy in Thoracic Esophageal Carcinoma Without Cervical Lymph Node Involvement |
|
- Procedure: Two-field lymphadenectomy
- Procedure: Three-field lymphadenectomy
|
Interventional |
Not Applicable |
- Chinese Academy of Medical Sciences
- Beijing Cancer Hospital
- Henan Cancer Hospital
- (and 8 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Long term survival
- Disease free survival
- Locoregional recurrence
- Postoperative complications
|
786 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02448953 |
NKTRDP-2015BAI12B08-03 |
|
January 2015 |
September 2017 |
December 2019 |
May 20, 2015 |
May 20, 2015 |
|
- Cancer hospital, Chinese Academy of Medical Sciences
Beijing, Beijing, China
|
| 33 |
NCT02445456 |
Recruiting |
Feasibility of Sentinel Lymph Node Biopsy in Rectal Cancer |
|
- Drug: Sienna+ injection
- Other: MRI scan
- Procedure: Surgery to excise rectal cancer
- Device: Sentimag probe
|
Interventional |
Not Applicable |
- Oxford University Hospitals NHS Trust
- University of Leeds
- Endomagnetics Limited
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Number of participants experiencing of adverse or hypersensitivity reaction
- Number of operations where effects of tracer injection can be detected by surgeon during surgery
- Qualitative assessment of surgical difficulty due to tracer injection using 5-point visual analogue scale and content analysis of surgeon's free-text comments
- (and 5 more...)
|
40 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02445456 |
R37025/CN339 |
SentiRect |
December 2016 |
March 2019 |
June 2019 |
May 15, 2015 |
April 5, 2018 |
|
- Churchill Hospital
Oxford, United Kingdom
|
| 34 |
NCT03006588 |
Recruiting |
EUS-FNA for Retropharyngeal Lymph Node (RPLN) in Recurrent Nasopharyngeal Carcinoma (NPC) Patients |
|
- Procedure: EUS-FNA for RPLN in NPC patients
|
Interventional |
Phase 2
Phase 3 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
|
100 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03006588 |
EUS-FNA for RPLN(2016) |
|
January 2014 |
December 2018 |
December 2018 |
December 30, 2016 |
January 2, 2017 |
|
- Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
|
| 35 |
NCT02803151 |
Recruiting |
A Clinical Trial of Stereotactic Ablative Radiotherapy for Metastatic Lymphadenopathy |
- Metastasis of Malignant Neoplasm to Lymph Node
|
- Radiation: Stereotactic ablative radiotherapy
|
Interventional |
Not Applicable |
- National Taiwan University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Local control (Response Evaluation Criteria In Solid Tumors version 1.1)
- Patient reported outcome (Quality of Life questionnaire)
- Acute toxicity (Common Toxicity Criteria for Adverse Events version 4)
- (and 3 more...)
|
59 |
All |
20 Years and older (Adult, Senior) |
NCT02803151 |
201601023RINA |
|
May 2016 |
May 2019 |
May 2020 |
June 16, 2016 |
March 10, 2017 |
|
- National Taiwan University Hospital
Tapei, Taiwan
|
| 36 |
NCT03009227 |
Recruiting |
Study of Oncological Outcomes of D3 Lymph Node Dissection in Colon Cancer |
- Colonic Neoplasms Malignant
|
- Procedure: Colonic resection with D2 lymph node dissection
- Procedure: Colonic resection with D3 lymph node dissection
|
Interventional |
Not Applicable |
- Petrov Research Institute of Oncology
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Overall survival
- Disease-free survival
- Postoperative morbidity
- (and 7 more...)
|
768 |
All |
18 Years and older (Adult, Senior) |
NCT03009227 |
COL-1 |
COLD |
January 2017 |
January 2025 |
January 2025 |
January 4, 2017 |
October 11, 2017 |
|
- State Scientific Centre of Coloproctology
Moscow, Russian Federation - P. Herzen Moscow Oncology Research Institute
Moscow, Russian Federation - Rostov Research Institute of Oncology
Rostov, Russian Federation - (and 3 more...)
|
| 37 |
NCT02056886 |
Recruiting |
Medico-economic Study of Three Strategies of Sentinel Lymph Node Analysis in Operable Breast Cancer |
|
- Procedure: SLN detection +/- complementary axillary lymphadenectomy
|
Interventional |
Not Applicable |
- Institut Cancerologie de l'Ouest
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Medico-economic study : medical cost between 3 different sentinel lymph node analysis (histological analysis or molecular biology) in the management of patients treated for invasive breast carcinoma.
|
920 |
Female |
18 Years to 65 Years (Adult) |
NCT02056886 |
ICO-N-2012-08
2012-A01504-39 |
SAGE |
July 2013 |
January 2017 |
January 2022 |
February 6, 2014 |
August 31, 2016 |
|
- ICO Paul Papin
Angers, France - ICO René Gauducheau
Nantes - St Herblain, France - Institut Curie
Paris, France
|
| 38 |
NCT02908178 |
Recruiting |
Comparative Effectiveness of Sentinel Lymph Node Biopsy for Ductal Carcinoma In Situ |
|
- Procedure: Sentinel lymph node biopsy (SLNB)
|
Observational |
|
- Yale University
- Patient-Centered Outcomes Research Institute
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Side effects
- Mastectomy received
- Radiation therapy received
- (and 5 more...)
|
20000 |
Female |
67 Years to 94 Years (Senior) |
NCT02908178 |
PCORI-SW-1 |
|
January 25, 2017 |
June 2018 |
July 2018 |
September 20, 2016 |
October 24, 2017 |
|
- SEER-Medicare Dataset
Bethesda, Maryland, United States
|
| 39 |
NCT03247478 |
Recruiting |
Computed Tomography (CT) Reconstruction for Axillary Lymph Node Structure |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Sensitivity, specificity, positive-predictive value (PPV) and negative-predictive value (NPV) of Computed tomography (CT) reconstruction for axillary lymph node status after neoadjuvant chemotherapy.
- Rreceiver operating characteristic (ROC) curve analysis
|
156 |
Female |
Child, Adult, Senior |
NCT03247478 |
BCP20 |
CTREP |
August 25, 2017 |
October 31, 2019 |
June 30, 2020 |
August 11, 2017 |
August 28, 2017 |
|
- Peking University Cancer Hospital
Beijing, Beijing, China
|
| 40 |
NCT03127995 |
Recruiting |
Hypofractionated vs Standard Radiotherapy in Breast Cancer With an Indication for Regional Lymph Node Irradiation About Lymphedema Occurrence |
|
- Radiation: HYPOFRACTIONATED
- Radiation: NORMOFRACTIONATED
|
Interventional |
Not Applicable |
- UNICANCER
- National Cancer Institute, France
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Arm Lymphedema
- Functional Assessment
- Aesthetics Assessment-FIBROSIS
- (and 9 more...)
|
1012 |
Female |
18 Years to 85 Years (Adult, Senior) |
NCT03127995 |
UC-0107/1604
2016-A00702-49 |
HYPOG-01 |
September 2016 |
September 2021 |
September 2029 |
April 25, 2017 |
April 28, 2017 |
|
- Clinique de l'Europe
Amiens, France - Institut de Cancerologie de L'Ouest-Paul Papin
Angers, France - Hôpital Jean Minjoz
Besancon, France - (and 25 more...)
|
| 41 |
NCT03280134 |
Not yet recruiting |
A Prospective Validation Cohort Study of a Prediction System on nSLN Metastasis in Early Breast Cancer |
- Lymph Node Metastases
- Breast Cancer
- Predictive Cancer Model
|
- Procedure: axillary lymph node dissection (ALND)
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- disease-free survival (DFS)
- local recurrent rate
- overal survival (OS)
|
388 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT03280134 |
ZJCH-CK19B |
|
February 2018 |
December 2018 |
December 2018 |
September 12, 2017 |
November 14, 2017 |
|
- Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China
|
| 42 |
NCT02147405 |
Recruiting |
PET Imaging and Lymph Node Assessment of IRIS in People With AIDS |
- Immune Reconstitution Inflammatory Syndrome
|
|
Observational |
|
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Correlate LN inflammation (by FDG-PET) and degree of fibrosis as assessed by immunohistochemistry (IHC) with development of IRIS and degree of immune reconstitution after 1 year of ART.
- Pathogenesis studies to evaluate role of myeloid cells in periphery and LN in IRIS.
- FDG-PET measurements and correlations with viremia, biomarkers, OI, immune recovery of B cells and Tfh cells with ART.
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT02147405 |
140124
14-I-0124 |
|
May 22, 2014 |
April 1, 2019 |
April 1, 2020 |
May 26, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 43 |
NCT03381092 |
Recruiting |
Sentinel Lymph Node Biopsy in Clinically Node-negative Early Breast Cancer Patients After Neoadjuvant Chemotherapy |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Positive Rate of Axillary Sentinel Lymph Nodes.
- Detection Rate of Axillary Sentinel Lymph Nodes.
- Rate of Axillary Lymph Node Dissection.
- (and 2 more...)
|
348 |
Female |
up to 70 Years (Child, Adult, Senior) |
NCT03381092 |
BCP21 |
|
December 22, 2017 |
December 26, 2019 |
December 26, 2020 |
December 21, 2017 |
January 23, 2018 |
|
- Peking University Cancer Hospital
Beijing, Beijing, China
|
| 44 |
NCT02494063 |
Recruiting |
Sentinel Lymph Node Biopsy in Patients With Early Stages Cervical Cancer |
|
- Procedure: Sentinel lymph node biopsy
|
Observational |
|
- Charles University, Czech Republic
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Recurrence rate at the 24th month of follow-up (cervical recurrences after fertility-sparing procedures will be excluded)
- Prevalence of symptomatic pelvic lymphocele
- Prevalence of lower extremity lymphedema
- (and 9 more...)
|
350 |
Female |
18 Years to 75 Years (Adult, Senior) |
NCT02494063 |
CEEGOG CX-01
16-31643A
ENGOT-Cx 2 |
SENTIX |
June 2016 |
June 2021 |
June 2021 |
July 10, 2015 |
July 19, 2017 |
|
- Gynecologic Oncology Center in Prague
Prague, Czechia
|
| 45 |
NCT02466737 |
Recruiting |
Comparison of Axillary Sentinel Lymph Node Biopsy Versus no Axillary Surgery |
|
- Procedure: no axillary surgery versus SLNB
- Procedure: SLNB versus completion ALND
|
Interventional |
Not Applicable |
- University of Rostock
- German Cancer Aid (Deutsche Krebshilfe), funding
- German Breast Group (GBG Forschungs GmbH), data analysis
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
|
- invasive disease-free survival (IDFS) after breast-conserving surgery
|
7095 |
Female |
18 Years and older (Adult, Senior) |
NCT02466737 |
GBG 75 / ABCSG 43 |
INSEMA |
September 2015 |
September 2024 |
|
June 9, 2015 |
October 13, 2017 |
|
- BGZ Dornbirn, Gynäkologie
Dornbirn, Austria - LKH Uni-Klinikum Graz, Gynäkologie
Graz, Austria - Universitätsfrauenklinik Salzburg
Salzburg, Austria - (and 151 more...)
|
| 46 |
NCT02998619 |
Recruiting |
Radiotherapy of Pelvic Lymph Nodes in High Risk Prostate Cancer - A Retrospective Analysis |
- Prostatic Neoplasms Benign
- Radiotherapy Side Effect
- Lymph Node Disease
|
|
Observational |
|
- Kantonsspital Graubuenden
|
Other |
- Time Perspective: Retrospective
|
- Progression-free survival
- Toxicity (CTCAE v4.03)
|
60 |
Male |
18 Years to 100 Years (Adult, Senior) |
NCT02998619 |
BASEC 2016-01325 |
|
December 2016 |
June 2018 |
June 2018 |
December 20, 2016 |
December 20, 2016 |
|
- Kantonsspital Graubuenden
Chur, Switzerland
|
| 47 |
NCT02834988 |
Recruiting |
Sentinel Lymph Node Dissection (SLND) in Patients With Apparent Early Stage Endometrial Cancer |
|
- Procedure: Sentinel Lymph Node Dissection
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- SLND Positivity Rate in Study Participants
- Rate of NPV and FNPV of the SLND Procedure in Study Participants Who Undergo Partial or Full Lymphadenectomy.
- Proportion of Types of Lymph Node Metastases Described by SLND in Study Participants
- (and 2 more...)
|
1700 |
Female |
18 Years and older (Adult, Senior) |
NCT02834988 |
20151012 |
|
July 28, 2016 |
January 2020 |
June 2020 |
July 15, 2016 |
December 7, 2017 |
|
- University of Miami
Miami, Florida, United States
|
| 48 |
NCT02781259 |
Recruiting |
Selective Lymph Node Dissection Using Fluorescent Dye in Node-positive Breast Cancer |
|
- Procedure: Axillary lymph node dissection
- Drug: Indocyanine green
- Device: Imaging devices
|
Interventional |
Phase 4 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Number of metastatic lymph nodes in fluorescent positive lymph nodes and fluorescent negative lymph nodes confirmed by pathologist
- Clinicopathological factors associated with lymph node metastasis in fluorescent negative lymph nodes
|
150 |
Female |
20 Years to 70 Years (Adult, Senior) |
NCT02781259 |
2015-01-046-007 |
|
May 2016 |
February 2017 |
April 2017 |
May 24, 2016 |
September 20, 2016 |
|
- Samsung medical center
Seoul, Korea, Republic of
|
| 49 |
NCT02612012 |
Recruiting |
Axillary Radiotherapy for Early Stage Breast Cancer With Limited Positive Sentinel Lymph Nodes |
|
- Radiation: axillary radiotherapy
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Axillary recurrence
- Local-regional recurrence
- Disease free survival
- (and 2 more...)
|
475 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT02612012 |
FDRT-BC002 |
|
October 2015 |
October 2019 |
|
November 23, 2015 |
November 23, 2015 |
|
- Fudan University Shanghai Cancer Center
Shanghai, China
|
| 50 |
NCT02869152 |
Recruiting |
Sentinel Lymph Node Mapping in Rectal Cancer |
|
- Other: Endoscopic injection of 99mTc-sulfur colloid
- Other: Endoscopic injection of ICG
- Other: Endoscopic injection of Spot
- (and 3 more...)
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- 1st Phase: Detection rate of sentinel lymph node in first 6 patients
- 2nd Phase: Detection rate of refined protocol in identifying SLN
- Size of the SLN according to pathologic analysis
- (and 5 more...)
|
26 |
All |
18 Years and older (Adult, Senior) |
NCT02869152 |
19120 |
|
August 2016 |
March 2019 |
|
August 16, 2016 |
October 31, 2016 |
|
- University of Virginia
Charlottesville, Virginia, United States
|
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