| 1 |
NCT02820376 |
Recruiting |
Assessment of Differential Renal Function by CT in Living Donors |
|
- Other: Differential renal function assessment by 4D CT
|
Interventional |
Not Applicable |
- Central Hospital, Nancy, France
- Institut National de la Santé Et de la Recherche Médicale, France
- University of Lorraine
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- degree of agreement
- Intra- and inter-observer reproducibility of CT DRF measurement
- Radiation dose exposure for each technique
- (and 2 more...)
|
51 |
All |
18 Years and older (Adult, Senior) |
NCT02820376 |
2016-A00543-48
PSS 2016 / DOVISCAN - MANDRY / |
DOVISCAN |
June 2016 |
June 2018 |
January 2019 |
July 1, 2016 |
July 24, 2017 |
|
|
| 2 |
NCT03400085 |
Not yet recruiting |
Pilot Study of an mHealth Intervention for Living Donor Follow-up |
- Living Donors
- Nephrectomy
- Kidney
|
- Other: mHealth application
|
Interventional |
Not Applicable |
- Johns Hopkins University
- Texas Transplant Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- 6-month compliance to follow-up
- 1-year compliance to follow-up
- 2-year compliance to follow-up
- (and 3 more...)
|
400 |
All |
18 Years and older (Adult, Senior) |
NCT03400085 |
IRB00162212 |
mHealth |
May 2018 |
May 2022 |
May 2022 |
January 17, 2018 |
April 13, 2018 |
|
- Methodist Specialty and Transplant Hospital
San Antonio, Texas, United States
|
| 3 |
NCT02509949 |
Recruiting |
Effects of Dexmedetomidine on Delirium After Living Donor Renal Transplantation in Adult Patients |
- Postoperative Delirium After Living Donor Renal Transplantation
|
- Drug: Dexmedetomidine
- Drug: Saline
|
Interventional |
Phase 4 |
- Tao Zhang
- First Affiliated Hospital, Sun Yat-Sen University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
|
100 |
All |
18 Years to 59 Years (Adult) |
NCT02509949 |
DDRT |
|
May 2015 |
April 2018 |
|
July 28, 2015 |
April 25, 2017 |
|
- First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China
|
| 4 |
NCT02864485 |
Recruiting |
Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases |
- Colorectal Cancer
- Liver Metastases
|
- Procedure: live donor liver transplantation
|
Interventional |
Not Applicable |
- University Health Network, Toronto
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- patient survival
- disease-free survival
- patterns of cancer recurrence after liver transplantation
- (and 4 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT02864485 |
15-9382-C |
|
August 3, 2016 |
September 2023 |
December 2023 |
August 12, 2016 |
March 23, 2018 |
|
- Toronto General Hospital
Toronto, Ontario, Canada
|
| 5 |
NCT03488953 |
Recruiting
New |
Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated, Irresectable Colorectal Liver Metastases |
- Colorectal Cancer Metastatic
- Liver Metastases
|
- Procedure: Living donor liver transplantation with two-staged hepatectomy.
|
Interventional |
Not Applicable |
- Jena University Hospital
- University Hospital Tuebingen
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Overall survival three years after 2nd-stage of hepatectomy
- Disease-free survival three years after 2nd-stage of hepatectomy
- Morbidity of the recipient
- Morbidity of the donor
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03488953 |
AVG-001 |
LIVERT(W)OHEAL |
April 10, 2018 |
June 30, 2023 |
December 15, 2023 |
April 5, 2018 |
April 5, 2018 |
|
- Jena University Hospital
Jena, Germany - University Hospital Tübingen
Tübingen, Germany
|
| 6 |
NCT02830841 |
Recruiting |
Liver Protection of RIPC in Pediatric Living Donor Liver Transplantation |
- Hepatic Ischemic and Reperfusion Injury
|
- Device: remote ischemic preconditioning(RIPC)
- Device: Sham RIPC
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Transplanted liver function(AST)
- Transplanted liver function(ALT)
- Occurrence of early graft dysfunction(EGD)
- (and 7 more...)
|
200 |
All |
3 Months to 6 Years (Child) |
NCT02830841 |
Renji[2016]002k |
RIPC-PLDT |
February 2016 |
December 2017 |
December 2017 |
July 13, 2016 |
July 13, 2016 |
|
- Renji Hospital
Shanghai, Shanghai, China
|
| 7 |
NCT02342119 |
Recruiting |
Increasing Equity in Transplant Evaluation and Living Donor Kidney Transplantation |
|
- Other: Talking About Living Kidney Donation
- Other: Kidney Transplant Fast Track
|
Interventional |
Not Applicable |
- University of Pittsburgh
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Receipt of Kidney Transplant
- Time to complete transplant evaluation
- Kidney Transplant Decision Making (assessed using increasing levels of preference for a living versus deceased donor)
- (and 3 more...)
|
1289 |
All |
18 Years and older (Adult, Senior) |
NCT02342119 |
PRO13100511
5R01DK101715-04 |
|
May 2015 |
July 2019 |
July 2019 |
January 19, 2015 |
November 21, 2017 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
| 8 |
NCT03138226 |
Recruiting |
Living Donor Uterus Transplantation Between Identical Twins |
- Absolute Uterine Factor Infertility
- Cervical Cancer
|
- Procedure: uterus transplantation
|
Observational |
|
- Sahlgrenska University Hospital, Sweden
- University Hospital Tuebingen
- University of Belgrade
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Live births after uterus transplantation
|
6 |
Female |
20 Years to 40 Years (Adult) |
NCT03138226 |
Twin UTx |
UTx-twin |
January 1, 2017 |
December 31, 2020 |
December 31, 2025 |
May 3, 2017 |
May 3, 2017 |
|
- Sahlgrenska University Hospital
Gothenburg, Sweden
|
| 9 |
NCT02845154 |
Recruiting |
Intermittent Portal and Graft Purge in Living Donor Liver Transplantation |
- Hypotension
- Ischemia Reperfusion Injury
|
- Other: bolus purge
- Other: Intermittent purge
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Post-reperfusion syndrome
- Graft ischemia reperfusion injury
- Severity of post-reperfusion syndrome
- One month patient mortality
|
80 |
All |
20 Years to 60 Years (Adult) |
NCT02845154 |
LDLDPURGE |
IPLDLT |
October 2015 |
August 2017 |
November 2017 |
July 27, 2016 |
March 27, 2017 |
|
- Liver transplantation program - Gastroenterology surgical center
Mansoura, Dakahlia, Egypt - Liver transplantation project - Gastroenterology surgical center - Mansoura university
Mansoura, Dakahlia, Egypt - Gastroenterology surgical center - Mansoura university
Mansoura, Dakahlia, Egypt
|
| 10 |
NCT03363945 |
Recruiting |
Cellular Immunotherapy in Recipients of HLA-matched, Living Donor Kidney Transplants |
- Kidney Transplant Rejection
|
|
Interventional |
Phase 3 |
- Medeor Therapeutics, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Functional immune tolerance defined as
|
75 |
All |
18 Years to 65 Years (Adult) |
NCT03363945 |
MDR-101-MLK |
|
March 15, 2018 |
January 2022 |
January 2022 |
December 6, 2017 |
April 17, 2018 |
|
- University of Colorado Denver
Aurora, Colorado, United States - Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States - Ohio State University Medical Group
Columbus, Ohio, United States - (and 4 more...)
|
| 11 |
NCT03084666 |
Recruiting |
Remote Ischemic Preconditioning Living Donor Renal Transplant Protocol |
|
- Device: Zimmer ATS tourniquet system
|
Interventional |
Not Applicable |
- University of Alabama at Birmingham
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Prevention
|
- Remote Ischemic Preconditioning (RIPC)
|
150 |
All |
19 Years and older (Adult, Senior) |
NCT03084666 |
F130312023 |
|
July 2, 2014 |
June 13, 2018 |
June 30, 2019 |
March 21, 2017 |
February 6, 2018 |
|
- UAB Department of Anesthesiology and Perioperative Medicine
Birmingham, Alabama, United States
|
| 12 |
NCT03408106 |
Recruiting |
Prospective Clinical Trial of HIV+ Living Donor Kidney Donation for HIV+ Recipients |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Adverse events
- chronic kidney disease
- hypertension
- (and 2 more...)
|
20 |
All |
21 Years and older (Adult, Senior) |
NCT03408106 |
IRB00138153 |
|
August 1, 2017 |
August 1, 2022 |
December 31, 2022 |
January 23, 2018 |
January 23, 2018 |
|
- Johns Hopkins University
Baltimore, Maryland, United States
|
| 13 |
NCT03478215 |
Recruiting
New |
Mesenchymal Stromal Cells in Living Donor Kidney Transplantation |
- Renal Transplantation
- Mesenchymal Stem Cells
|
- Drug: Tacrolimus
- Drug: Mycophenolate Mofetil
- Drug: Basiliximab
|
Interventional |
Phase 2 |
- Ahmed Osama Gaber, MD
- Center for Cell and Gene Therapy, Baylor College of Medicine
- The Methodist Hospital System
- Houston Methodist Transplant & Surgery Center of Excellence
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Other
|
- Number of participants without any infusional toxicity, occurring within 24 hours of infusion.
- Number of participants without any acute rejection, graft loss, or death at 6 months post transplant.
|
24 |
All |
18 Years to 65 Years (Adult) |
NCT03478215 |
Pro00012858
U1111-1169-2289 |
|
February 2016 |
July 2018 |
July 2019 |
March 27, 2018 |
March 27, 2018 |
|
- Houston Methodist Hospital System
Houston, Texas, United States
|
| 14 |
NCT03494010 |
Not yet recruiting
New |
Hybrid Closed-Loop Insulin Delivery System in Type 1 Diabetes Candidates for a Living Donor Kidney Transplant |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Duration of use of hybrid closed-loop (HCL) system
- Kidney transplantation outcome - graft rejection
- Kidney transplantation outcome - infections
- (and 6 more...)
|
50 |
All |
18 Years to 65 Years (Adult) |
NCT03494010 |
2000022558 |
|
May 1, 2018 |
April 30, 2020 |
April 30, 2021 |
April 11, 2018 |
April 11, 2018 |
|
|
| 15 |
NCT03465397 |
Recruiting |
Individualization of the Immunological Risk Based on Selective Biomarkers in Living-donor Renal Recipients |
- Kidney Transplant Failure and Rejection
|
- Diagnostic Test: biomarkers driven immunosuppressive therapy
|
Interventional |
Phase 4 |
- ORIOL BESTARD
- Department of Health, Generalitat de Catalunya
- Hospital Universitari de Bellvitge
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- composite
- mortality
- kidney graft loss
- (and 9 more...)
|
164 |
All |
18 Years and older (Adult, Senior) |
NCT03465397 |
BIOIMMUN |
BIOIMMUN |
November 10, 2017 |
November 2020 |
November 2020 |
March 14, 2018 |
March 16, 2018 |
|
- Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Barcelona, Spain - Hospital Universitari Germans Trias I Pujol
Badalona, Spain - Fundació Puigvert
Barcelona, Spain - (and 3 more...)
|
| 16 |
NCT03292445 |
Recruiting |
Inducing Graft Tolerance in HLA Haplotype Matched Related and 3 Ag Matched Unrelated Living Donor Kidney Transplantation |
|
- Procedure: Immune tolerance after kidney transplant
- Drug: Donor blood stem cells and T cells
|
Interventional |
Early Phase 1 |
- Samuel Strober
- California Institute for Regenerative Medicine
- Stanford University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction of dependence on immunosuppressive drugs to prevent graft rejection.
- Incidence of rejection episodes requiring corticosteroid therapy
- Incidence of graft loss.
|
24 |
All |
18 Years to 60 Years (Adult) |
NCT03292445 |
40442 |
CIRM |
February 14, 2017 |
February 14, 2020 |
February 14, 2024 |
September 25, 2017 |
September 25, 2017 |
|
- Stanford University Medical Center
Palo Alto, California, United States
|
| 17 |
NCT02957552 |
Recruiting |
Safety and Tolerance of Immunomodulating Therapy With Donor-specific MSC in Pediatric Living-Donor Liver Transplantation |
- Pediatric Liver Transplantation
|
- Biological: Mesenchymal Stem Cells
|
Interventional |
Phase 1 |
- University Hospital Tuebingen
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with MYSTEP-score grade 3 and grade 2 (toxicity of MSC infusion)
- Number of participants with occurrence of any severe adverse events (SAE)
- Graft function after liver transplantation - Number of participants with abnormal liver tests
- (and 4 more...)
|
7 |
All |
8 Weeks to 18 Years (Child, Adult) |
NCT02957552 |
MYSTEP1
2014-003561-15 |
MYSTEP1 |
March 10, 2017 |
December 2018 |
December 2020 |
November 7, 2016 |
June 20, 2017 |
|
- University Children's Hospital
Tuebingen, Germany
|
| 18 |
NCT03036930 |
Recruiting |
Immunogenicity of Nonavalent HPV Vaccine Administered Prior to Living Donor Renal Transplantation in Adult Women: A Prospective, Single-Arm, Multi-Center Clinical Trial |
|
- Other: Laboratory Biomarker Analysis
- Other: Questionnaire Administration
- Biological: Recombinant Human Papillomavirus Nonavalent Vaccine
|
Interventional |
Phase 2 |
- National Cancer Institute (NCI)
|
NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- HPV vaccine-type-specific seroconversion rates among female living donor kidney transplant recipients who receive >= 1 doses of the vaccine >= 30 days prior to transplantation
- HPV vaccine-type-specific seroconversion rates
- Persistence and stability of HPV vaccine-type-specific GMT
- (and 3 more...)
|
180 |
Female |
18 Years to 49 Years (Adult) |
NCT03036930 |
NCI-2017-00116
N01-CN-2012-00035
NCI2015-06-02
NWU2015-06-02
N01CN00035
P30CA060553 |
|
June 23, 2017 |
January 1, 2020 |
February 1, 2020 |
January 31, 2017 |
April 13, 2018 |
|
- University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States - Cedars Sinai Medical Center
Los Angeles, California, United States - UCSF Medical Center-Mount Zion
San Francisco, California, United States - (and 2 more...)
|
| 19 |
NCT01165762 |
Recruiting |
Combined Blood Stem Cell and Kidney Transplant of One Haplotype Match Living Donor Pairs. |
|
|
Interventional |
Not Applicable |
- Stanford University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Long term freedom from transplant immunosuppressive drugs, safety, rate of infection, graft survival and patient survival.
|
25 |
All |
18 Years to 60 Years (Adult) |
NCT01165762 |
SU-06232010-6408
P01HL075462 |
|
July 2010 |
June 2021 |
June 2021 |
July 20, 2010 |
December 7, 2016 |
|
- Stanford University School of Medicine
Stanford, California, United States
|
| 20 |
NCT03099434 |
Recruiting |
Expanding Live Donor Kidney Transplantation Through Advocacy Training and Social Media |
- Kidney Failure
- Kidney Diseases
|
- Behavioral: Facebook App
- Behavioral: Live Donor Champion + Facebook App
|
Interventional |
Not Applicable |
- Johns Hopkins University
- University of Alabama at Birmingham
- Northwestern University
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double (Care Provider, Investigator)
- Primary Purpose: Other
|
- Live donor kidney transplantation
- Live Donor Inquiries
- knowledge of live donation
- comfort initiating conversations
|
1350 |
All |
18 Years and older (Adult, Senior) |
NCT03099434 |
RDK111966A |
ENGAGE |
April 1, 2017 |
April 2022 |
April 2022 |
April 4, 2017 |
December 7, 2017 |
|
- Northwestern University
Evanston, Illinois, United States - Johns Hopkins University
Baltimore, Maryland, United States
|
| 21 |
NCT03435510 |
Not yet recruiting |
Implementation of the Live Donor Champion Program |
|
- Behavioral: Live Donor Champion Program
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Acceptability - Implementation Outcome
- Adoption - Implementation Outcome
- Appropriateness - Implementation Outcome
- (and 9 more...)
|
210 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT03435510 |
IRB00157440 |
LDC |
April 2018 |
April 2021 |
April 2023 |
February 16, 2018 |
February 16, 2018 |
|
- Washington University in Saint Louis
Saint Louis, Missouri, United States - University of Pennsylvania
Philadelphia, Pennsylvania, United States
|
| 22 |
NCT02474199 |
Recruiting |
Donor Alloantigen Reactive Tregs (darTregs) for Calcineurin Inhibitor (CNI) Reduction |
- Liver Transplant Recipient
- Living Donor (of the Respective Liver Transplant Recipient)
|
- Biological: darTregs
- Drug: Acetaminophen
- Drug: Diphenhydramine
- (and 2 more...)
|
Interventional |
Phase 1
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Clinical Trials in Organ Transplantation in Children
|
NIH / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of >/=Grade 3 Adverse Events (AEs)
- Incidence of Study Defined Grade 3 or Higher Infections
- Incidence of Any Malignancy
- (and 5 more...)
|
18 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02474199 |
DAIT CTOTC-12 |
ARTEMIS |
September 2015 |
April 2018 |
December 2018 |
June 17, 2015 |
June 26, 2017 |
|
- University of California at San Francisco
San Francisco, California, United States - Northwestern University Comprehensive Transplant Ctr
Chicago, Illinois, United States - Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
| 23 |
NCT01786525 |
Recruiting |
House Calls and Decision Support: Improving Access to Live Donor Transplantation |
- Chronic Kidney Disease
- End-Stage Renal Disease
|
- Behavioral: House Calls
- Behavioral: Web-Based Patient-Centered Decision Support Intervention
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- The primary outcome for this study is the proportion of enrolled patients with live donor kidney transplants
- Higher proportion of enrolled patients with live donor inquires and evaluations; higher proportion of patients will be in LDKT Readiness stages 4/5 by the 12-week assessment.
|
150 |
All |
21 Years and older (Adult, Senior) |
NCT01786525 |
2012P000332
R01DK098727 |
|
June 2013 |
November 2018 |
December 2018 |
February 8, 2013 |
July 13, 2017 |
|
- Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
| 24 |
NCT03284073 |
Not yet recruiting |
First Clinical Live-Donor Uterus Transplantation Trial In Egypt |
- Primary Uterine Infertility
|
- Procedure: Uterus transplantation
|
Interventional |
Not Applicable |
- Amro M. Hetta, M.Sc.
- Al-Azhar University
- Mansoura Urology and Nephrology Center
- Talkha Central Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Surviving transplants (8-12 months)
- Spontaneous menstruation commencement
- Pregnancy rate
- Live birth rate
|
11 |
Female |
18 Years to 45 Years (Adult) |
NCT03284073 |
OG4 |
|
October 31, 2018 |
September 30, 2019 |
October 31, 2019 |
September 15, 2017 |
April 24, 2018 |
|
- Mansoura Urology and Nephrology Center
Mansoura, Al-Dakahliya, Egypt
|
| 25 |
NCT03090646 |
Recruiting |
Use of Financial Incentives to Increase Live Kidney Donor Follow-up Compliance |
- Living Donors
- Nephrectomy
- Kidney
|
- Other: Financial Incentive
|
Interventional |
Not Applicable |
- Johns Hopkins University
- The Living Legacy Foundation of Maryland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- 6-month donor follow-up compliance
- 1-year donor follow-up compliance
- 2-year donor follow-up compliance
- (and 3 more...)
|
320 |
All |
18 Years and older (Adult, Senior) |
NCT03090646 |
IRB00126158 |
|
March 22, 2017 |
April 1, 2023 |
April 1, 2023 |
March 27, 2017 |
March 15, 2018 |
|
- Johns Hopkins Hospital
Baltimore, Maryland, United States
|
| 26 |
NCT03277430 |
Recruiting |
Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study |
- Mayer Rokitansky Kuster Hauser Syndrome
- Mullerian Aplasia
- Uterus; Absence, Congenital
- (and 3 more...)
|
- Procedure: Live donor uterus transplantation
- Procedure: Deceased donor uterus transplantation
- Drug: Tacrolimus
|
Interventional |
Phase 3 |
- Institute for Clinical and Experimental Medicine
- University Hospital, Motol
- Sahlgrenska University Hospital, Sweden
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Efficacy of uterus transplantation.
- Comparison of efficacy of uterus transplantation from live donors versus deceased donors.
- Rate of adverse events after uterus transplantation
- (and 3 more...)
|
20 |
Female |
18 Years to 60 Years (Adult) |
NCT03277430 |
2044/15 (NM-15-01) |
UTxLD/DBD |
October 9, 2015 |
December 31, 2020 |
December 31, 2025 |
September 11, 2017 |
September 13, 2017 |
|
- Institute for Clinical and Experimental Medicine
Prague, Czechia
|
| 27 |
NCT02987023 |
Recruiting |
Uterus Transplantation From Live Donors With Robotic Assisted Surgery - Gothenburg II |
|
- Procedure: uterus transplantation
|
Observational |
|
- Sahlgrenska University Hospital, Sweden
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Live births after uterus transplantation
- Development of children after uterus transplantation
|
10 |
Female |
20 Years to 38 Years (Adult) |
NCT02987023 |
SahlgrenskaUTx |
UTX-robot |
November 2016 |
December 2022 |
December 2022 |
December 8, 2016 |
December 8, 2016 |
|
- Sahlgrenska University Hospital
Gothenburg, Sweden
|
| 28 |
NCT03496610 |
Not yet recruiting
New |
Surgeon Infiltration QL Block Comparison |
- Quadratus Lumborum Block
- Surgical Wound Infiltration
|
- Drug: Liposomal Bupivicaine
- Procedure: QL Block
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Opioid consumption
- Numeric pain scores as measured by the NRS 11
- Percentage of GI Complications
- Physical activity after surgery as measured by walking test
|
40 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03496610 |
Pro00087144 |
|
June 1, 2018 |
June 1, 2019 |
June 1, 2019 |
April 12, 2018 |
April 12, 2018 |
|
- Duke University
Durham, North Carolina, United States
|
| 29 |
NCT03268850 |
Recruiting |
Living Kidney Donor Lost Wages Trial |
|
- Other: Standard of Care
- Behavioral: Wage Reimbursement A
- Behavioral: Wage Reimbursement B
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Care Provider, Investigator)
- Primary Purpose: Other
|
- Effectiveness of wage reimbursement on LDKT rate
- Effect of wage reimbursement on racial disparities in LDKT
- Difference between reimbursement arms
|
735 |
All |
18 Years and older (Adult, Senior) |
NCT03268850 |
2017P000213 |
|
February 5, 2018 |
December 31, 2023 |
December 31, 2023 |
August 31, 2017 |
February 23, 2018 |
|
- BIDMC Transplant Center
Boston, Massachusetts, United States
|
| 30 |
NCT03395574 |
Recruiting |
Effect of Terlipressin on Cerebral Oxygen Saturation During Liver Transplantation |
- Terlipressin Adverse Reaction
- Liver Transplantation
|
- Drug: Terlipressin
- Drug: Normal saline
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- cerebral oxygen saturation
- resistive index of middle cerebral artery
- peak velocity, end diastolic velocity of middle cerebral arteries
- (and 7 more...)
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT03395574 |
N-113-2017 |
|
January 25, 2018 |
May 2018 |
May 2018 |
January 10, 2018 |
March 12, 2018 |
|
- Kasr Alainy Hospital , Faculty of Medicine
Cairo, Egypt
|
| 31 |
NCT02579408 |
Recruiting |
Quantifying Steatosis in Liver Transplant Donors |
- Non-alcoholic Fatty Liver Disease
- Evidence of Liver Transplantation
|
|
Observational |
|
- The University of Hong Kong
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Recipient allograft short-term outcomes
- Recipient allograft long-term outcomes
- Association of controlled attenuation parameter scores with clinical parameters of LDLT donor
|
100 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02579408 |
CAP LDLT |
|
October 2015 |
September 2018 |
March 2019 |
October 19, 2015 |
May 11, 2016 |
|
- Department of Medicine and Department of Surgery, The University of Hong Kong, Queen Mary Hospital
Hong Kong, Hong Kong
|
| 32 |
NCT02012153 |
Recruiting |
Mesenchymal Stromal Cells in Kidney Transplant Recipients |
- Kidney Transplant Rejection
|
- Biological: Mesenchymal Stromal Cells
|
Interventional |
Phase 1 |
- Mario Negri Institute for Pharmacological Research
- A.O. Ospedale Papa Giovanni XXIII
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Circulating naïve and memory T cell count (CD45RA/CD45RO) (flow cytometry analysis).
- T-cell function by ELISPOT assay in mixed lymphocyte reaction.
- Number of adverse events.
- (and 2 more...)
|
6 |
All |
18 Years and older (Adult, Senior) |
NCT02012153 |
MSC-Tx tolerance
2013-003221-29 |
|
December 2013 |
December 2022 |
March 2023 |
December 16, 2013 |
January 17, 2018 |
|
- U.O. Nefrologia e Dialisi
Bergamo, Italy
|
| 33 |
NCT01095172 |
Recruiting |
RituxiMab INDuction in Renal Transplantation |
- Function of Renal Transplant
|
- Drug: Rituximab
- Drug: Tacrolimus
- Drug: Mycophenylate mofetil
- (and 2 more...)
|
Interventional |
Phase 4 |
- Guy's and St Thomas' NHS Foundation Trust
- Astellas Pharma Europe Ltd.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Estimated GFR (calculated using the Cockcroft-Gault formula)
- Biopsy proven acute rejection (based on Banff classification)
- Allograft survival
- (and 3 more...)
|
612 |
All |
18 Years and older (Adult, Senior) |
NCT01095172 |
RituxiRT
2009-017066-23
95769119
9154 |
ReMIND |
November 2010 |
October 2019 |
October 2023 |
March 30, 2010 |
August 19, 2016 |
|
- South West Transplant Centre
Plymouth, Devon, United Kingdom - East Kent Hospitals NHS Foundation Trust
Canterbury, Kent, United Kingdom - Glasgow Renal and Transplant Unit
Glasgow, United Kingdom - (and 3 more...)
|
| 34 |
NCT02633826 |
Recruiting |
Pre-formed Alloreactivity in Renal Transplant Recipients |
- Kidney Transplantation
- Acute Graft Rejection
|
|
Observational |
|
- Martina Sester
- Saarland University
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- graft function
- Creatinine
- Cystatin C
- (and 2 more...)
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT02633826 |
Pre-formed alloreactivity |
|
November 2015 |
April 2017 |
April 2018 |
December 17, 2015 |
January 23, 2017 |
|
- Saarland University
Homburg, Saarland, Germany - Medizinische Klinik II, Aachen University
Aachen, Germany - Charité Berlin
Berlin, Germany - (and 10 more...)
|
| 35 |
NCT03006419 |
Recruiting |
Basiliximab vs Low-dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients |
- Kidney Transplant Rejection
- Kidney Transplant; Complications
|
- Drug: Basiliximab
- Drug: Thymoglobulin
|
Interventional |
Phase 4 |
- Coordinación de Investigación en Salud, Mexico
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Biopsy proven acute rejection
- Delayed graft function
- Slow graft function
- (and 5 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03006419 |
R-2016-3001-61 |
|
December 2016 |
April 2018 |
October 2018 |
December 30, 2016 |
January 26, 2017 |
|
- Umae Hospital Especialidades 14 Adolfo Ruiz Cortines
Veracruz, Mexico
|
| 36 |
NCT02252055 |
Recruiting |
The ONE Study ATDC Trial |
|
|
Interventional |
Phase 1
Phase 2 |
- Nantes University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of biopsy-confirmed acute rejection (BCAR)
- Time to first acute rejection episode
- Severity of acute rejection episodes
- (and 11 more...)
|
16 |
All |
18 Years and older (Adult, Senior) |
NCT02252055 |
RC13_0441 |
ONEatDC |
March 2015 |
June 2019 |
October 2019 |
September 29, 2014 |
June 2, 2017 |
|
- Nantes University hospital
Nantes, France
|
| 37 |
NCT00319657 |
Recruiting |
Kidney and Blood Stem Cell Transplantation That Eliminates Requirement for Immunosuppressive Drugs |
|
|
Interventional |
Phase 1 |
- Stanford University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Discontinuation of maintenance immunosuppressive drugs
|
15 |
All |
18 Years to 65 Years (Adult) |
NCT00319657 |
367
P01HL075462-02 |
|
July 2004 |
July 2021 |
July 2021 |
April 27, 2006 |
November 30, 2016 |
|
- Stanford University, School of Medicine
Stanford, California, United States
|
| 38 |
NCT02544919 |
Recruiting |
Lipids and Neurological Complications in Liver Transplantation |
- Neurological Complications
|
- Drug: SMOF lipid (SMOFLIPID) pre treatment
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- post-transplant neurological complications
- Graft functions
- survival
|
80 |
All |
20 Years to 60 Years (Adult) |
NCT02544919 |
SMOF_NEURO_1 |
LNCLT |
September 2015 |
September 2017 |
December 2017 |
September 9, 2015 |
March 27, 2017 |
|
- Liver transplantation project - Gastroenterology surgical center - Mansoura university
Mansoura, Dakahlia, Egypt
|
| 39 |
NCT01957943 |
Recruiting |
Omega 3 Lipid Emulsions and Liver Transplantation |
- Ischemia Re-perfusion Injury
|
- Dietary Supplement: SMOFLipid
- Dietary Supplement: equivalent volume of 10% glucose solution
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Supportive Care
|
- Ischemia reperfusion injury
- Liver functions
- Early graft regeneration
- Late graft regeneration
|
114 |
All |
20 Years to 60 Years (Adult) |
NCT01957943 |
LTX_SMOF_PRE_Eg |
OTLT |
May 2014 |
December 2017 |
March 2018 |
October 8, 2013 |
March 28, 2017 |
|
- Liver transplantation program - Gastroenterology surgical center - Mansoura university
Mansoura, Dakahlia, Egypt
|
| 40 |
NCT03354910 |
Not yet recruiting |
House Calls and Peer Mentorship |
- Chronic Kidney Disease
- End-Stage Renal Disease
|
- Behavioral: House Call
- Behavioral: Peer Mentorship
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
- Medical University of South Carolina
- Patient-Centered Outcomes Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Live donor kidney transplants
- Live donor evaluations
- Live donor inquiries
|
374 |
All |
21 Years and older (Adult, Senior) |
NCT03354910 |
2017P000521
PCORI 1609-36589 |
HC+PM |
April 30, 2018 |
January 31, 2021 |
January 31, 2021 |
November 28, 2017 |
March 16, 2018 |
|
|
| 41 |
NCT02711826 |
Recruiting |
Treg Therapy in Subclinical Inflammation in Kidney Transplantation |
- Kidney Transplant
- Adult Living Donor Kidney Transplant Recipients
- Renal Transplant
- Living Kidney Donor
|
- Biological: Polyclonal Regulatory T Cells
- Biological: Donor-Alloantigen-Reactive Regulatory T Cells
- Drug: Everolimus
- (and 9 more...)
|
Interventional |
Phase 1
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Clinical Trials in Organ Transplantation
|
NIH / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Timing of Banff 2A or higher acute cell-mediated rejection and/or acute antibody mediated rejection
- Incidence of Banff 2A or higher acute cell-mediated rejection and/or acute antibody mediated rejection
- Timing of study defined Grade 3 or higher infection
- (and 21 more...)
|
45 |
All |
18 Years and older (Adult, Senior) |
NCT02711826 |
DAIT CTOT-21 |
TASK |
May 2016 |
October 1, 2021 |
October 1, 2021 |
March 17, 2016 |
January 30, 2018 |
|
- University of Alabama, Birmingham
Birmingham, Alabama, United States - University of California at San Francisco
San Francisco, California, United States - University of Michigan
Ann Arbor, Michigan, United States - (and 3 more...)
|
| 42 |
NCT02700217 |
Recruiting |
Does Adding Spinal Anaesthesia to a General Anaesthetic Technique Influence Readiness for Discharge in Patients Having Hand Assisted Laparoscopic Live Donor Nephrectomy |
|
- Procedure: Bupivacaine and Diamorphine
- Procedure: Remifentanil, Propofol and Cistracurium
- Procedure: Bupivacaine and Rectus Sheath injection
|
Interventional |
Not Applicable |
- Manchester University NHS Foundation Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Assessment of readiness for discharge from hospital to determine Length of stay, after renal surgery, using a blinded Nurse assessment of patient.
- Assessment of Pain from surgery to discharge tested at intervals using an 11 point linear numerical rating scale utilised for assessment of pain.
- The total patient controlled analgesia (PCA) morphine consumption
- (and 3 more...)
|
90 |
All |
18 Years to 65 Years (Adult) |
NCT02700217 |
R04134 |
|
February 2016 |
February 2018 |
April 2018 |
March 7, 2016 |
February 16, 2017 |
|
- Central Manchester University Hospitals NHS Foundation Trust
Manchester, United Kingdom
|
| 43 |
NCT02533180 |
Recruiting |
Evaluation of Donor Specific Immune Senescence and Exhaustion as Biomarkers of Tolerance Post Liver Transplantation |
- Liver Transplant
- Liver Transplantation
|
- Biological: Immunosuppression withdrawal
|
Interventional |
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Immune Tolerance Network (ITN)
|
NIH / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of participants who achieve operational tolerance
- Proportion of participants who develop Donor-Specific AlloAbs (DSA) or de novo anti-human leukocyte antigen human leukocyte antigen (HLA) antibodies
- The incidence of acute rejection, steroid resistant rejection, and chronic rejection
- (and 15 more...)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02533180 |
DAIT ITN056ST |
OPTIMAL |
October 2015 |
October 2019 |
October 2021 |
August 26, 2015 |
January 16, 2018 |
|
- University of California, San Francisco Medical Center
San Francisco, California, United States - Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States - Massachusetts General Hospital
Boston, Massachusetts, United States - (and 4 more...)
|
| 44 |
NCT03477656 |
Recruiting
New |
Evaluation of 2 Techniques of Apheresis to Desensitize ABO Incompatible Kidney Transplant Candidates |
|
- Procedure: Large volume specific immunoadsorption
- Procedure: Double Filtration Plasmapheresis
|
Interventional |
Not Applicable |
- University Hospital, Toulouse
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Success rate
- Differential cost-efficacy ratio of support for patients receiving a live donor kidney transplant Incompatible ABO and benefiting from a desensitization procedure
- Surgical complication rate during the desensitization sessions
- (and 23 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03477656 |
RC31/16/8767 |
DADI |
April 2018 |
February 2021 |
August 2021 |
March 26, 2018 |
April 18, 2018 |
|
- University Hospital Toulouse (Hospital Rangueil)
Toulouse, France
|
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