| 101 |
NCT03155360 |
Recruiting |
Infants Colics : Towards a Migrainous Origin ? |
- Colic, Infantile
- Migraine
- Migraine Equivalents
|
- Other: Non interventional study
|
Observational |
|
- Central Hospital, Nancy, France
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Proportion of real colics according to Wessel definition
- Proportion of migrainous parents
- Proportion of Infant colics according the feeling parents
- (and 5 more...)
|
300 |
All |
60 Days to 180 Days (Child) |
NCT03155360 |
2017-A00185-48 |
COLIGRAINE |
May 18, 2017 |
November 1, 2017 |
November 1, 2017 |
May 16, 2017 |
August 9, 2017 |
|
- Dr BORSA-DORION Anne
Nancy, France
|
| 102 |
NCT02854930 |
Not yet recruiting |
Near Death Experience (NDE) and Migraine |
- Migraine
- Near Death Experience
|
|
Observational |
|
- Assistance Publique Hopitaux De Marseille
|
Other |
- Time Perspective: Prospective
|
|
100 |
All |
Child, Adult, Senior |
NCT02854930 |
2014-47 |
|
January 2017 |
January 2018 |
March 2018 |
August 4, 2016 |
August 4, 2016 |
|
- Assistance Publique Hôpitaux de Marseille Hôpital de la Timone
Marseille, France
|
| 103 |
NCT03478735 |
Recruiting
New |
Ultrasound Greater Occipital Nerve Block at C2 Level Compared to Landmark-based Greater Occipital Nerve Block |
- Occipital Neuralgia
- Cervicogenic Headache
- Migraine Without Aura
|
- Procedure: Ultrasound Guided Greater Occipital Nerve Block at C2
- Procedure: Landmark-Based Greater Occipital Nerve Block
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Numeric Rating Scale (NRS) Pain Score
- Change in number of patients with medication overuse
- Change in number of headache days per month
- Change in Headache Impact Test (HIT-6) Score
|
32 |
All |
18 Years and older (Adult, Senior) |
NCT03478735 |
17-002724 |
|
July 17, 2017 |
January 2019 |
January 2019 |
March 27, 2018 |
March 27, 2018 |
|
- Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
| 104 |
NCT03445403 |
Not yet recruiting |
Offset Analgesia as a Measure of Central Sensitization in Children |
- Chronic Pain Syndrome
- Chronic Daily Headache
- Functional Abdominal Pain Syndrome
- (and 2 more...)
|
|
Interventional |
Not Applicable |
- Boston Children’s Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Screening
|
- Response to Offset analgesia stimulus
- Response to a Controlled Stimulus
- Response to a Constant Stimulus
- (and 2 more...)
|
60 |
All |
10 Years to 17 Years (Child) |
NCT03445403 |
P00025596 |
|
April 1, 2018 |
April 1, 2019 |
June 1, 2019 |
February 26, 2018 |
March 7, 2018 |
|
|
| 105 |
NCT03472378 |
Recruiting |
Can DFN-15 Terminate Migraine With Allodynia? |
- Migraine With Aura
- Migraine Without Aura
- Allodynia
|
- Drug: DFN-15
- Other: Placebo
|
Interventional |
Phase 2 |
- Hartford Hospital
- Rami Burstein, PhD, Beth Israel Deaconess Medical Center
- Dr. Reddy's Laboratories Limited
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Headache Pain Intensity
- Allodynia
|
100 |
All |
18 Years to 64 Years (Adult) |
NCT03472378 |
HHC-2017-0224 |
|
April 1, 2018 |
August 1, 2018 |
September 1, 2018 |
March 21, 2018 |
March 23, 2018 |
|
- Hartford HealthCare Headache Center
West Hartford, Connecticut, United States
|
| 106 |
NCT03472092 |
Not yet recruiting |
Distinct Mechanisms of Cognitive Behavioral Therapy Effects in Youth With Migraine |
- Headache, Migraine
- Migraine
- Migraine Disorders
- Headache
|
- Behavioral: Cognitive Behavioral Therapy (CBT)
- Drug: Placebo
- Drug: Amitriptyline
|
Interventional |
Phase 2 |
- Children's Hospital Medical Center, Cincinnati
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Change in functional resonance imaging (fMRI)
- Change in pain modulation
|
240 |
All |
10 Years to 17 Years (Child) |
NCT03472092 |
CIN0101-CAP Imaging Study |
|
September 2018 |
December 2022 |
March 2023 |
March 21, 2018 |
March 27, 2018 |
|
- Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
|
| 107 |
NCT03471039 |
Recruiting |
PACAP27 Headache Properties in Migraine Without Aura Patients |
|
- Drug: PACAP27
- Drug: Saline
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Health Services Research
|
- Headache Scores
- Facial blood flow (flushing)
|
30 |
All |
18 Years to 60 Years (Adult) |
NCT03471039 |
H-17016232 |
|
August 30, 2017 |
December 30, 2018 |
December 30, 2018 |
March 20, 2018 |
March 20, 2018 |
|
- Danish Headache Center
Glostrup, Denmark
|
| 108 |
NCT03465826 |
Not yet recruiting |
Developing a Mobile Health Pain-Coping Skills Training Program for the Treatment of Chronic Migraine: AIM 4 |
- Chronic Migraine, Headache
|
- Behavioral: PainCOACH Pain Coping Skills Training
- Behavioral: Treatment as Usual
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- Duke University
- Hackensack University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Feasibility and Engagement
- Change in Migraine Disability
- Change in HIT-6
- (and 4 more...)
|
144 |
All |
18 Years and older (Adult, Senior) |
NCT03465826 |
18-01218 |
|
May 1, 2021 |
February 28, 2023 |
November 30, 2023 |
March 14, 2018 |
March 14, 2018 |
|
|
| 109 |
NCT03453203 |
Not yet recruiting |
Treatment of Cervical Pain in Chronic Migraine |
|
- Other: Osteopathic Manipulative Treatment Using Counterstrain
|
Interventional |
Not Applicable |
- University Hospitals Cleveland Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Treatment
|
- Treatment of Cervical Pain in Chronic Migraine
|
30 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03453203 |
UHClevelandMC1 |
|
April 29, 2018 |
December 29, 2018 |
December 29, 2018 |
March 5, 2018 |
March 7, 2018 |
|
|
| 110 |
NCT03337620 |
Recruiting |
Efficacy and Safety of Tx360® Transnasal Sphenopalatine Ganglion Block in the Treatment of Chronic Migraine |
|
|
Interventional |
Phase 3 |
- Tian Medical Inc.
- TAMM Net, Inc.
- Clinvest Research, LLC
- New England Institute for Clinical Research
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Number of Migraine Headaches During Treatment Phase
- Change in Number of Migraine Headache Days Post-Treatment
- Safety/Tolerability of TX360 Device Based on Adverse Effects
|
180 |
All |
18 Years to 65 Years (Adult) |
NCT03337620 |
16-001TI |
|
September 20, 2017 |
January 1, 2019 |
June 1, 2019 |
November 9, 2017 |
March 5, 2018 |
|
- Hartford Headache Center
East Hartford, Connecticut, United States - Waterbury Neurology
Middlebury, Connecticut, United States - Yale University
New Haven, Connecticut, United States - (and 5 more...)
|
| 111 |
NCT03280342 |
Recruiting |
Cognitive Effects of Immediate Release Topiramate vs Extended Release Topiramate in Patients With Migraine |
|
- Drug: IR-TPM (Topamax)
- Drug: XR-TPM (Trokendi XR)
|
Interventional |
Phase 2 |
- University of Minnesota - Clinical and Translational Science Institute
- Supernus Pharmaceuticals, Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Controlled Oral Word Association Test (COWA)-generative phonemic fluency
- Measures of semantic verbal fluency
- Digit Span Backward
- (and 2 more...)
|
60 |
All |
18 Years to 65 Years (Adult) |
NCT03280342 |
CETIM |
|
October 30, 2017 |
June 2018 |
June 2019 |
September 12, 2017 |
November 14, 2017 |
|
- University of Minnesota
Minneapolis, Minnesota, United States - Prism Research
Saint Paul, Minnesota, United States
|
| 112 |
NCT03228355 |
Recruiting |
Headache Inducing Effect of Cromakalim in Migraine Patients |
|
- Drug: Levcromakalim
- Drug: Saline
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Cerebral hemodynamic
- Headache
- Migraine attack
|
12 |
All |
18 Years to 60 Years (Adult) |
NCT03228355 |
Levcromakalim |
|
May 1, 2017 |
July 2018 |
July 2018 |
July 24, 2017 |
February 14, 2018 |
|
- Danish headache center
Copenhagen, Glostrup, Denmark
|
| 113 |
NCT03220113 |
Recruiting |
Treatment of Chronic Migraine Headaches. |
- Chronic Migraine Without Aura, Intractable
- Migraine With Typical Aura
- Migraine Disorders
|
- Combination Product: Dexamethasone, Lidocaine, Thiamine cohort
|
Interventional |
Phase 1
Phase 2 |
- Corona Doctors Medical Clinics, Inc.
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Assessment of the safety to the De-Novo treatment formula in study patients
- Assessment of the clinical response to the De-Novo treatment formula in study patients consisting of a lone composite measure
|
100 |
All |
10 Years to 90 Years (Child, Adult, Senior) |
NCT03220113 |
2017/05/1 |
Migraine |
July 1, 2017 |
July 1, 2018 |
July 1, 2019 |
July 18, 2017 |
April 4, 2018 |
|
- Corona Doctors Medical Clinics Inc
Corona, California, United States
|
| 114 |
NCT03099070 |
Recruiting |
Acute Stress Response in Migraine Sufferers |
|
- Behavioral: Stress
- Other: Fasting
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Headache/Medication Use
- Time to next headache attack
- Medication use
- Pain Scores
|
212 |
All |
18 Years to 65 Years (Adult) |
NCT03099070 |
2016P001834 |
|
March 8, 2017 |
May 31, 2020 |
May 31, 2020 |
April 4, 2017 |
April 4, 2017 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
| 115 |
NCT03097536 |
Recruiting |
Migraine and Homeostasis:What Can we Learn From Glucose |
|
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The difference in blood glucose on days with migraine compared to blood glucose on days without migraine
- The primary outcome is the change in pain score from the time of pain plateau to the pain score at 120 minutes as measured by a visual analogue scale.
|
30 |
All |
18 Years to 65 Years (Adult) |
NCT03097536 |
2015P000419 |
|
March 2016 |
June 2018 |
September 2018 |
March 31, 2017 |
April 5, 2017 |
|
- Beth Israel Deaconess Medial Center
Boston, Massachusetts, United States
|
| 116 |
NCT03055767 |
Recruiting |
Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population |
- Migraine Disorders
- Headache, Migraine
- Pediatrics
|
- Drug: OnabotulinumtoxinA
- Other: Placebo (Saline)
|
Interventional |
Phase 2 |
- University of California, Irvine
- American Society of Regional Anesthesia
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Pain scores (Intensity)
- Change in duration of migraine episode
- Frequency of Migraine
- (and 8 more...)
|
26 |
All |
8 Years to 17 Years (Child) |
NCT03055767 |
UCIANES09 |
|
March 1, 2017 |
December 2019 |
March 2020 |
February 16, 2017 |
March 3, 2017 |
|
- Gottschalk Medical Plaza
Irvine, California, United States - UC Irvine Medical Center
Orange, California, United States
|
| 117 |
NCT03036761 |
Recruiting |
Interest of Auriculotherapy in Prophylaxis of Migraine and Headache in Patients With Migraines |
|
- Procedure: Auriculotherapy
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of days with migraine and headache
- Number of days with migraine
- Number of days with non migrainous headache
|
90 |
Female |
18 Months to 80 Years (Child, Adult, Senior) |
NCT03036761 |
2016/58
2016-A01534-47 |
Migauric |
January 2017 |
May 2019 |
December 2019 |
January 30, 2017 |
March 1, 2017 |
|
- Hopital Foch
Suresnes, France
|
| 118 |
NCT02991430 |
Recruiting |
A Non-Invasive Neuromodulation Device for Prevention of Episodic Migraine Headache |
|
- Device: active neuromodulation for episodic migraine headache
- Device: placebo neuromodulation for episodic migraine headache
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- change in migraine headache days (MHD)
- normalized reduction in migraine headache days
- change in medication usage
- (and 7 more...)
|
120 |
All |
18 Years to 65 Years (Adult) |
NCT02991430 |
SNS-MIG-02 |
|
June 30, 2017 |
July 2018 |
September 2018 |
December 13, 2016 |
October 31, 2017 |
|
- Mayo Clinic
Scottsdale, Arizona, United States - Neurology Research Institute
West Palm Beach, Florida, United States - Diamond Headache Clinic
Chicago, Illinois, United States - (and 7 more...)
|
| 119 |
NCT02969642 |
Recruiting |
Study of Low-level Laser Therapy in the Acute Treatment of Migraine |
|
- Device: Argus Migraine Treatment device
|
Interventional |
Phase 2 |
- The San Francisco Clinical Research Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Differences between treatment groups in pain free rates at 2 hours post treatment.
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02969642 |
AP 1001 |
|
March 2016 |
May 2017 |
July 2017 |
November 21, 2016 |
December 2, 2016 |
|
- San Francisco Clinical Research Center
San Francisco, California, United States
|
| 120 |
NCT02903680 |
Recruiting |
RCT of IV Dexamethasone to Prevent Relapse in the Treatment of Migraine in a Paediatric ED |
|
- Drug: Dexamethasone group
- Drug: Placebo group
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Prevention
|
- incidence of relapse following discharge from the ED
- mean level of pain
- associated symptoms (i.e. nausea, vomiting, photophobia and sonophobia),
- (and 2 more...)
|
116 |
All |
8 Years to 18 Years (Child, Adult) |
NCT02903680 |
3662 |
|
May 2014 |
May 2019 |
June 2019 |
September 16, 2016 |
October 20, 2017 |
|
- CHU Sainte Justine
Montréal, Quebec, Canada
|
| 121 |
NCT02866084 |
Recruiting |
Neuromodulation Treatment of Vestibular Migraines |
|
|
Interventional |
Not Applicable |
- University of Miami
- Scion NeuroStim
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Dizziness Handicap Inventory
- Headache Impact Test
- Activities Balance Confidence Interval
- (and 3 more...)
|
10 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02866084 |
20160566 |
|
September 28, 2016 |
August 2018 |
August 2018 |
August 15, 2016 |
December 12, 2017 |
|
- University of Miami Miller School of Medicine
Miami, Florida, United States
|
| 122 |
NCT02824250 |
Recruiting |
Mindfulness and Migraine Research Study |
|
|
Interventional |
Not Applicable |
- California Pacific Medical Center Research Institute
- Kaiser Permanente
- Sutter Health
- National Center for Complementary and Integrative Health (NCCIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- recruitment rate
- treatment adherence
- diary completion
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02824250 |
897613
1R01AT00908101 |
M&M |
March 9, 2017 |
December 31, 2018 |
May 31, 2019 |
July 6, 2016 |
April 28, 2017 |
|
- Palo Alto Medical Foundation Research Institute
Palo Alto, California, United States
|
| 123 |
NCT02777359 |
Recruiting |
Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches |
|
- Procedure: the transcatheter closure of PFO
|
Interventional |
Phase 2 |
- First Affiliated Hospital Xi'an Jiaotong University
- Second Affiliated Hospital of Xi'an Jiaotong University
- Fourth Military Medical University
- Southwest Hospital, China
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- migraine days after randomization
|
100 |
All |
18 Years to 60 Years (Adult) |
NCT02777359 |
XJTU1AF-CRF-2015-008 |
|
January 2017 |
January 2018 |
June 2018 |
May 19, 2016 |
July 19, 2017 |
|
- First Affiliated Hospital of Xian JiaotongUniversity
Xi'an, Shaanxi, China
|
| 124 |
NCT02720211 |
Recruiting |
Spectacle Tints and Thin-Films for Migraine |
- Headache Migraine Chronic
|
- Device: Gray tinted spectacle lenses
- Device: Thin-Film spectacle lenses
|
Interventional |
Not Applicable |
- University of Utah
- Axon Optics, LLC
- Mayo Clinic
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Headache frequency
- Headache Impact
|
140 |
All |
18 Years to 60 Years (Adult) |
NCT02720211 |
IRB #86498 |
|
August 2016 |
July 2018 |
October 2018 |
March 25, 2016 |
November 17, 2017 |
|
- Mayo Clinic
Phoenix, Arizona, United States - Brigham and Women's Hospital; John R Graham Headache Center; Harvard University,
Boston, Massachusetts, United States - Headache Center of the Neuroscience Institute; Hofstra Northwell Health; Northshore University Hospital
Great Neck, New York, United States - John A Moran Eye Center; University of Utah Hospitals and Clinics
Salt Lake City, Utah, United States
|
| 125 |
NCT02706015 |
Not yet recruiting |
Cefaliv® Compared to Neosaldina® in the Treatment of Migraine Attacks |
|
- Drug: Cefaliv® & Placebo
- Drug: Neosaldina® & Placebo
|
Interventional |
Phase 3 |
- Ache Laboratorios Farmaceuticos S.A.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Evaluate the efficacy and non-inferiority of Cefaliv® compared to Neosaldina® in pain relief
- The remission of the pain after use of the investigational product, without use of a rescue medication;
- The relief of pain after use of the investigational product, without use of a rescue medication;
- (and 3 more...)
|
216 |
All |
18 Years to 66 Years (Adult, Senior) |
NCT02706015 |
ACH-CFL-03(10/14) |
|
October 2020 |
May 2021 |
July 2021 |
March 11, 2016 |
April 9, 2018 |
|
- Ache Laboratorios Farmaceuticos
Guarulhos, São Paulo, Brazil
|
| 126 |
NCT02630719 |
Recruiting |
Timolol Eye Drops in the Treatment of Acute Migraine Headache |
|
- Drug: Timolol eye drops
- Drug: Artificial tears
|
Interventional |
Not Applicable |
- University of Missouri, Kansas City
- Truman Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Timolol Eye Drops in the Treatment of Acute Migraine Headache
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02630719 |
15-152
#15-060 |
|
January 2016 |
June 2018 |
June 2018 |
December 15, 2015 |
October 26, 2017 |
|
- Truman Medical Center
Kansas City, Missouri, United States
|
| 127 |
NCT02485418 |
Recruiting |
Low- Dose Propofol Infusion as an Abortive Treatment for Migraine Headaches in Pediatric Patients |
|
|
Interventional |
Not Applicable |
- University of Texas Southwestern Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement in Headache Pain Score
- Duration of analgesia
- Total propofol dose
|
40 |
All |
7 Years to 18 Years (Child, Adult) |
NCT02485418 |
Propofol2014 |
|
June 2015 |
October 2017 |
|
June 30, 2015 |
October 27, 2016 |
|
- Children's Health Children's Medical Center Dallas
Dallas, Texas, United States
|
| 128 |
NCT02447991 |
Recruiting |
Rizatriptan for Episodic Dizziness in Vestibular Migraine |
- Vestibular Migraine
- Migrainous Vertigo
|
- Drug: Rizatriptan
- Drug: Placebo
|
Interventional |
Phase 2
Phase 3 |
- Robert W. Baloh
- University of California, Los Angeles
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Proportion of treated vestibular migraine (VM) attacks in which subjects experience a reduction in severity rating
- Treatment Satisfaction at 48 hours
|
200 |
All |
18 Years to 65 Years (Adult) |
NCT02447991 |
IRB12-001549 |
|
December 2014 |
June 2019 |
June 2019 |
May 19, 2015 |
February 13, 2018 |
|
- University of California, Los Angeles
Los Angeles, California, United States - Mayo Clinic
Rochester, Minnesota, United States
|
| 129 |
NCT02358681 |
Recruiting |
Intranasal Ketorolac Versus Intravenous Ketorolac for Treatment of Migraine Headaches in Children |
|
- Drug: Ketorolac, intranasal
- Drug: Ketorolac, intravenous
- Drug: Placebo, intravenous
- Drug: Placebo, intranasal
|
Interventional |
Phase 3 |
- Columbia University
- Migraine Research Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in pain score after analgesic administration (Faces Pain Scale - Revised (FPS-R)
- Time to achieve clinically significant reduction in pain after analgesic administration (Pain score)
|
80 |
All |
8 Years to 17 Years (Child) |
NCT02358681 |
AAAO1302 |
|
May 2015 |
December 2019 |
December 2019 |
February 9, 2015 |
April 10, 2018 |
|
- NewYork Presbyterian Morgan Stanley Children's Hospital
New York, New York, United States
|
| 130 |
NCT02351544 |
Recruiting |
Prospective, Multi-Center Evaluation of the Efficacy of Peripheral Trigger Decompression Surgery for Migraine Headaches |
|
- Drug: Botulinum Toxin Type A
- Procedure: Surgery
- Other: Daily headache diary
- (and 3 more...)
|
Interventional |
Not Applicable |
- Ohio State University
- University of Wisconsin, Madison
- Massachusetts General Hospital
- University Hospitals Cleveland Medical Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Migraine Headache Index (MHI) at 3 months
- Migraine Headache Index (MHI) at 6 months
- Migraine Headache Index (MHI) at 1 year
- (and 12 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02351544 |
2015H0024 |
|
September 2015 |
December 2019 |
December 2019 |
January 30, 2015 |
April 10, 2018 |
|
- Peled Plastic Surgery
San Francisco, California, United States - Premier Plastic Surgery of Kansas City
Olathe, Kansas, United States - Massachusetts General Hospital
Boston, Massachusetts, United States - (and 3 more...)
|
| 131 |
NCT02315833 |
Recruiting |
The Efficacy of L-cysteine in Prevention of Headache Attacks in Migraine Patients |
|
- Drug: Acetium
- Drug: Placebo
|
Interventional |
Not Applicable |
- Biohit Oyj
- The Finnish Funding Agency for Technology and Innovation (TEKES)
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of migraine attacks (NMA) per evaluation interval
- Number of migraine days (NMD) per evaluation period
|
200 |
All |
18 Years to 65 Years (Adult) |
NCT02315833 |
AC-MIGPREV-1 |
|
June 2014 |
December 2017 |
December 2017 |
December 12, 2014 |
June 23, 2017 |
|
- Terveystalo, Kamppi
Helsinki, Finland - Lääkärikeskus Aava, Helsingin Päänsärkykeskus Oy
Helsinki, Finland - Terveystalo, Jyväskylä
Jyväskylä, Finland - (and 2 more...)
|
| 132 |
NCT02259387 |
Recruiting |
Adolescents With Migraine: What's Stress Got To Do With It? |
|
|
Observational |
|
- University of Colorado, Denver
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Correlation between hair cortisol and perceived stress
- Correlation between headache frequency, perceived stress, and hair cortisol.
|
100 |
All |
13 Years to 17 Years (Child) |
NCT02259387 |
13-3128
UL1TR001082 |
Adostress |
October 2014 |
September 2017 |
October 2017 |
October 8, 2014 |
December 7, 2016 |
|
- Colorado Children's Hospital
Aurora, Colorado, United States
|
| 133 |
NCT02214550 |
Recruiting |
Chronic Pain Risk Associated With Menstrual Period Pain |
- Cystitis, Interstitial
- Dysmenorrhea
- Migraine Disorders
- (and 4 more...)
|
|
Interventional |
Phase 4 |
- NorthShore University HealthSystem Research Institute
- National Institutes of Health (NIH)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Change in participant bladder pain sensitivity from baseline.
- Change in Quantitative Sensory Testing (QST) parameters regarding pelvic hyperalgesia from baseline
- Differences in EEG recorded cortical activity among participants
|
255 |
Female |
18 Years to 45 Years (Adult) |
NCT02214550 |
EH13-094
1R01DK100368-01 |
CRAMPP |
July 2014 |
September 2019 |
September 2025 |
August 12, 2014 |
February 2, 2018 |
|
- NorthShore University Health System
Evanston, Illinois, United States
|
| 134 |
NCT02120326 |
Recruiting |
Evaluation of the Prophylactic Efficacy of tDCS in Chronic Migraine |
- Chronic Migraine as Defined by Criteria of International Headache Society (IHS)
|
- Device: Transcranial direct current stimulation of the motor cortex
- Device: simulation of Transcranial direct current stimulation of the motor cortex
|
Interventional |
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Comparison of the evolution of seizure frequency between the two groups
- Comparison of the evolution of seizure severity between the two groups
- Comparison of the evolution of crisis treatment use between the two groups
- (and 4 more...)
|
60 |
All |
18 Years to 65 Years (Adult) |
NCT02120326 |
DCIC13/48 |
Medis |
May 5, 2014 |
December 2018 |
December 2018 |
April 22, 2014 |
May 3, 2017 |
|
- Grenoble University Hospital
Grenoble, Isere, France - Hospital of Voiron
Voiron, Isere, France
|
| 135 |
NCT01942486 |
Recruiting |
Thin Film Spectacle Coatings to Reduce Light Sensitivity and Headaches in Child and Adolescent Patients With Migraine |
- Migraine Disorders
- Photophobia
|
- Device: Investigational Coating
|
Interventional |
Not Applicable |
- University of Utah
- Primary Children's Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- HIT-6 Score
- Headache Frequency as Measured Using a Self-Reporting Daily Diary
|
50 |
All |
7 Years to 18 Years (Child, Adult) |
NCT01942486 |
IRB_00065178 |
|
January 2014 |
October 2017 |
October 2017 |
September 16, 2013 |
May 3, 2017 |
|
- Moran Eye Center
Salt Lake City, Utah, United States
|
| 136 |
NCT01501045 |
Recruiting |
Effect of Transmagnetic Stimulation on Conditioned Pain Modulation (CPM) |
|
- Device: TMS system MagPro x100, Tonica Elektronik A/S, Denmark
|
Interventional |
Not Applicable |
- Rambam Health Care Campus
- German Research Foundation
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Pain scores as measured by pain numerical scale (NPS)
- Amplitude of pain-evoked potentials
- conditioned pain modulation (CPM)
|
200 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01501045 |
TMS-001 |
|
January 2011 |
July 2018 |
July 2018 |
December 29, 2011 |
October 3, 2017 |
|
- The lab of clinical neurophysiology, the faculty of medicine, Technion and Rambam Medical Center
Haifa, Israel
|
| 137 |
NCT02549898 |
Recruiting |
Investigation of Vascular Inflammation in Migraine Using Molecular Nano-imaging and Black Blood Imaging MRI |
- Migraine Headache
- Migraine Without Aura
|
- Drug: Feraheme
- Drug: Cilostazol
- Other: USPIO-MRI
- Other: BBI-MRI
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change in USPIO uptake during attacks of unilateral migraine without aura compared to baseline
- Change in arterial wall thickness during attacks of unilateral migraine without aura compared to baseline
- Change in arterial circumference as a proxy measure for vascular inflammation during attacks of unilateral migraine without aura compared to baseline
- (and 3 more...)
|
42 |
Female |
18 Years to 50 Years (Adult) |
NCT02549898 |
H-15005669 |
|
August 2015 |
June 2018 |
June 2018 |
September 15, 2015 |
January 5, 2018 |
|
- Rigshospitalet Glostrup
Glostrup, Denmark
|
| 138 |
NCT03221569 |
Recruiting |
Ketamine v. Metoclopramide/Diphenhydramine for Acute Management of Migraine in the Emergency Department |
|
- Drug: Intranasal ketamine
- Drug: Diphenhydramine
- Drug: metoclopramide
- Drug: Normal saline
|
Interventional |
Phase 4 |
- The Brooklyn Hospital Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pain scores
- Incidence of adverse events
- mean dose of rescue analgesia required
- length of stay
|
40 |
Male |
18 Years to 65 Years (Adult) |
NCT03221569 |
779354-2 |
|
February 1, 2016 |
February 1, 2018 |
February 1, 2018 |
July 18, 2017 |
July 18, 2017 |
|
- The Brooklyn Hospital Center
Brooklyn, New York, United States
|
| 139 |
NCT02945839 |
Not yet recruiting |
Improving Health Outcomes of Migraine Patients Who Present to the Emergency Department |
|
- Drug: Preventative Medication (PM)
- Behavioral: Enhanced Usual Care
- Behavioral: PMR (progressive muscle relaxation therapy)
|
Interventional |
Phase 4 |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Migraine Disability Assessment Scale (MIDAS) at 3 Months and Baseline
- Perceived Stress Scale (PSS)
- Number of days/week treated with acute medications
- Number of drug administrations/week for acute medications
|
90 |
All |
18 Years to 64 Years (Adult) |
NCT02945839 |
16-00548 |
|
April 2018 |
December 2018 |
December 2018 |
October 26, 2016 |
January 23, 2018 |
|
- New York University School of Medicine
New York, New York, United States
|
| 140 |
NCT00727974 |
Recruiting |
Genetic Analysis of Children With Cyclic Vomiting Syndrome (CVS) and Migraines |
|
|
Observational |
|
- Medical College of Wisconsin
- Children's Hospital and Health System Foundation, Wisconsin
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Identify novel genes that contribute to the risk of CVS using genomewide association analysis approach.
- Perform genotype-phenotype correlations between genetic profiles and various phenotypes of CVS (e.g. menstrual, Sato, calendar-tied) and migraine headaches (e.g. with aura, without aura, hemiplegic migraine)
|
880 |
All |
up to 21 Years (Child, Adult) |
NCT00727974 |
08/24
GC 607 |
|
January 2008 |
December 2019 |
December 2019 |
August 5, 2008 |
March 23, 2018 |
|
- Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States
|
| 141 |
NCT03434652 |
Recruiting |
Auricular Neurostimulation for Cyclic Vomiting Syndrome |
- Cyclic Vomiting Syndrome
- Abdominal Migraine
|
- Device: Percutaneous neurostimulation
|
Interventional |
Not Applicable |
- Medical College of Wisconsin
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Nausea and vomiting
- Pain
- Anxiety
- (and 4 more...)
|
50 |
All |
10 Years to 65 Years (Child, Adult) |
NCT03434652 |
1102505-4 |
|
January 31, 2018 |
June 30, 2019 |
December 31, 2019 |
February 15, 2018 |
February 16, 2018 |
|
- Children's Hospital of Wisconsin
Milwaukee, Wisconsin, United States
|
| 142 |
NCT03475784 |
Not yet recruiting
New |
Two Fluid Strategies for Prevention of Post-dural Puncture Headache |
- Post-Dural Puncture Headache
|
- Drug: Restrictive fluid therapy
- Drug: Liberal fluid therapy
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of post-dural puncture headache
- incidence of post-spinal hypotension
- Wong-Baker faces pain scale
- (and 2 more...)
|
100 |
Female |
18 Years to 40 Years (Adult) |
NCT03475784 |
N-98-2017 |
|
April 5, 2018 |
July 30, 2018 |
August 2, 2018 |
March 23, 2018 |
March 23, 2018 |
|
- Cairo University
Cairo, Egypt
|
| 143 |
NCT03464253 |
Not yet recruiting |
Prediction of Post-dural Puncture Headache in Parturients Undergoing Elective Caesarean Section |
- Postdural Puncture Headache
|
- Device: Performance of the transcranial Doppler (TCD)
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- TCD is able to predict the occurrence of PDPH in female patients undergoing spinal anesthesia for elective Caesarean Section
- verify that lumber puncture in PDPH patients leads to significant changes in cerebral blood flow supporting the theory of cerebral vasodilatation in PDPH patients.
|
90 |
Female |
18 Years to 40 Years (Adult) |
NCT03464253 |
4372/25-2-2018 |
|
April 1, 2018 |
July 1, 2018 |
October 30, 2018 |
March 13, 2018 |
March 13, 2018 |
|
|
| 144 |
NCT03385889 |
Recruiting |
Effects of Cervical Manual Therapy on Cervicogenic Headache |
- Unilateral Headache
- Musculoskeletal Neck Pain
|
- Procedure: Cervical Spine Mobilization
- Procedure: Cervical Spine Manipulation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Cervical Flexion Rotation Test (CFRT)
- Change in Joint Position Error
- Change in Balance as measured by NeuroCom Balance Master
|
75 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03385889 |
ShenandoahU(2017-2018) |
|
February 15, 2018 |
May 15, 2018 |
May 15, 2019 |
December 29, 2017 |
April 18, 2018 |
|
- Shenandoah University
Winchester, Virginia, United States
|
| 145 |
NCT03385772 |
Not yet recruiting |
The Sphenopalatine Ganglion Block for Post-dural Puncture Headache |
- Post-Dural Puncture Headache
|
- Procedure: Sphenopalatine ganglion block
|
Interventional |
Not Applicable |
- Brigham and Women's Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in VAS scores for headache at 4 hours after the sphenopalatine ganglion block.
- Time to first request of medication for symptom control after the sphenopalatine ganglion block,
- Need for blood patch
- (and 2 more...)
|
20 |
Female |
18 Years to 50 Years (Adult) |
NCT03385772 |
2017P002523 |
|
January 2018 |
December 2018 |
April 2019 |
December 28, 2017 |
December 28, 2017 |
|
|
| 146 |
NCT03347188 |
Recruiting |
A Study Comparing 1 Subcutaneous Dose Regimen of Fremanezumab Versus Placebo for the Prevention of PPTH |
|
- Drug: Fremanezumab
- Drug: Placebo
|
Interventional |
Phase 2 |
- Teva Branded Pharmaceutical Products, R&D Inc.
- Teva Pharmaceutical Industries
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- mean change in the monthly average number of headache days
- proportion of patients reaching at least 50% reduction in the monthly average number of headache days of any severity
- mean change in the number of headache days of at least moderate severity
- (and 4 more...)
|
172 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03347188 |
TV48125-CNS-20024 |
|
November 17, 2017 |
March 18, 2019 |
April 7, 2019 |
November 20, 2017 |
March 6, 2018 |
|
- Teva Investigational Site 14065
Phoenix, Arizona, United States - Teva Investigational Site 14048
Little Rock, Arkansas, United States - Teva Investigational Site 14052
Long Beach, California, United States - (and 22 more...)
|
| 147 |
NCT03225053 |
Not yet recruiting |
EFFECTS OF MIOFASCIAL RELEASE AND PERCUTANEOUS MICROELETROLYSIS IN TYPE HEADACHE |
- Trigger Point
- Tension-Type Headache
|
|
Interventional |
Not Applicable |
- Rodrigo Marcel Valentim da Silva
- Estácio Ponta Negra
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Headache impact test (HIT-6)
- Quality of life assessment (SF-36)
- Pain assessment
- (and 2 more...)
|
60 |
Female |
18 Years to 40 Years (Adult) |
NCT03225053 |
RSilva |
EMRPMITH |
August 20, 2017 |
December 20, 2017 |
January 30, 2018 |
July 21, 2017 |
July 21, 2017 |
|
|
| 148 |
NCT03171337 |
Not yet recruiting |
The Efficacy of Acupuncture and Fu's Subcutaneous Needling (FSN ) in Treating Chronic Tension-type Headache by fMRI |
- Chronic Tension-Type Headache
|
- Device: Acupuncture
- Device: Fu's Subcutaneous Needling (FSN)
- Device: Sham acupuncture
|
Interventional |
Not Applicable |
- Jiang Xumei
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- South China Normal University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Other
|
- Changes of Regional homogeneity data (ReHo) (using Kendall's coefficient of concordance as index) of Resting state fMRI of the whole brain (from the Vertex to Basicranial)
- Pain Visual Analogue Scale (VAS）
- Headache Impact Test (HIT-6)
|
45 |
All |
18 Years to 50 Years (Adult) |
NCT03171337 |
SouthSNU |
|
June 10, 2017 |
October 31, 2017 |
December 31, 2017 |
May 31, 2017 |
June 5, 2017 |
|
|
| 149 |
NCT03166358 |
Recruiting |
Yoga for Pediatric Tension-Type Headache |
|
|
Interventional |
Not Applicable |
- Matthew Morris
- Meharry Medical College
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Treatment
|
- Headache diary - changes in headache frequency over follow-up
- Headache diary - changes in headache intensity over follow-up
- Functional Disability Inventory - changes in pain-related functional disability over follow-up
- (and 8 more...)
|
40 |
All |
13 Years to 18 Years (Child, Adult) |
NCT03166358 |
15-07-410 |
|
September 1, 2015 |
August 1, 2018 |
August 1, 2018 |
May 25, 2017 |
May 25, 2017 |
|
- Meharry Medical College
Nashville, Tennessee, United States
|
| 150 |
NCT03142945 |
Recruiting |
Mechanical Diagnosis and Therapy vs Traditional Physical Therapy in the Treatment of Mechanical Headaches |
|
- Other: Traditional Physical Therapy
- Other: MDT based physical therapy
|
Interventional |
Not Applicable |
- Grand Valley State University
- Mary Free Bed Rehabilitation Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Neck Disability Index
- Numeric Pain Rating Scale
- Cervical Spine Range of Motion
|
34 |
All |
18 Years to 65 Years (Adult) |
NCT03142945 |
GrandVSU |
|
May 15, 2017 |
April 30, 2019 |
June 30, 2019 |
May 8, 2017 |
August 1, 2017 |
|
- Grand Valley State University
Grand Rapids, Michigan, United States
|
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