| 1 |
NCT02934152 |
Not yet recruiting |
Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication |
- Gastroesophageal Reflux Disease
|
- Drug: H pylori eradication
- Other: H pylori eradication timing
|
Interventional |
Phase 4 |
- National Taiwan University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Acid rebound
- Severity of acid rebound
|
400 |
All |
20 Years and older (Adult, Senior) |
NCT02934152 |
201607055MINC |
|
October 2016 |
September 2019 |
September 2019 |
October 14, 2016 |
October 19, 2016 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
| 2 |
NCT03425097 |
Recruiting |
Fexofenadine Use in Gastroesophageal Reflux Disease |
|
- Drug: Fexofenadine
- Drug: Placebo - Cap
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Mean percentage of reflux free days
- Mean number of reflux episodes per day
- Mean GERD-HRQL questionnaire score
- (and 4 more...)
|
40 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT03425097 |
IRB-44650 |
|
February 7, 2018 |
March 2019 |
May 2019 |
February 7, 2018 |
February 9, 2018 |
|
- Silicon Valley Gastroenterology 2490 Hospital Dr. Suite 211
Mountain View, California, United States
|
| 3 |
NCT02706938 |
Recruiting |
Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease |
- Gastroesophageal Reflux Disease
|
- Other: Head of bed elevation
- Other: Standard treatment
|
Interventional |
Not Applicable |
- Universidad Nacional de Colombia
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Symptom change
- Quality of life impact
- Patient preference
- Adverse events
|
124 |
All |
18 Years and older (Adult, Senior) |
NCT02706938 |
IBELGA |
IBELGA |
March 2016 |
July 2017 |
July 2017 |
March 11, 2016 |
October 27, 2016 |
|
- Clínica Fundadores
Bogotá D.C., Colombia
|
| 4 |
NCT03005080 |
Recruiting |
Pharmacogenetic Testing in Children With Persistent Gastroesophageal Reflux Disease |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of subjects who change medication due to pharmacogenomic results
- Number of subjects who have a repeat scope
|
30 |
All |
up to 18 Years (Child, Adult) |
NCT03005080 |
16-007265 |
|
December 2016 |
December 2017 |
December 2018 |
December 29, 2016 |
February 22, 2018 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
| 5 |
NCT03223116 |
Recruiting |
Radiofrequency Energy Delivery for Gastroesophageal Reflux Disease |
- Gastroesophageal Reflux Disease
|
- Procedure: Radiofrequency delivery
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from Baseline GERD-HRQL scores at 12 months
- Change from baseline esophagitis grade at 12 months
- Change from baseline esophageal acid exposure times from at 12 months
- (and 2 more...)
|
150 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03223116 |
CC2015 |
|
July 1, 2015 |
September 1, 2017 |
July 1, 2018 |
July 19, 2017 |
July 19, 2017 |
|
- Departmentof Gastroenterology Changhai Hospital
Shanghai, Shanghai, China
|
| 6 |
NCT03467438 |
Not yet recruiting |
Efficacy of Zinc L-carnosine in Maintaining Remission of Gastroesophageal Reflux Disease |
- Gastroesophageal Reflux Disease
|
- Drug: Zinc-l-carnosine
- Other: Placebo
|
Interventional |
Phase 4 |
- IRCCS Policlinico S. Matteo
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Gastroesophageal reflux disease (GERD) remission
- Quality of life
- Sustained GERD remission
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT03467438 |
GERDILOR17 |
GERDILOR |
April 1, 2018 |
April 1, 2019 |
April 1, 2019 |
March 16, 2018 |
March 16, 2018 |
|
- Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
|
| 7 |
NCT02907632 |
Recruiting |
Methoclopramide for Gastroesophageal Reflux in Premature Infants |
|
- Drug: Metoclopramide
- Drug: Placebo
|
Interventional |
Phase 4 |
- Nathalie Charpak
- Hospital Universitario San Ignacio
- Pontificia Universidad Javeriana
- Kangaroo Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Incidence of regurgitation episodes
- Episodes of apnea
- Bronchoaspiration
- (and 3 more...)
|
520 |
All |
up to 100 Days (Child) |
NCT02907632 |
2015/71 |
|
June 1, 2017 |
July 31, 2018 |
December 31, 2018 |
September 20, 2016 |
March 26, 2018 |
|
- Nathalie Charpak
Bogotá, Cundinamarca, Colombia
|
| 8 |
NCT02500264 |
Recruiting |
The Effect of Non Invasive Electrical Stimulation Therapy on Gastroesophageal Reflux Disease (GERD) Symptoms - Proof of Concept Study |
- Gastroesophageal Reflux Disease
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Symptoms severity questionnaire (heartburn and regurgitation) before and after treatment
- Esophageal acid exposure before and after treatment
|
12 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02500264 |
0293-15-RMC |
|
August 2015 |
October 2018 |
October 2018 |
July 16, 2015 |
September 20, 2017 |
|
- Rabin Medical Center
Petaẖ Tiqwa, Israel
|
| 9 |
NCT03184324 |
Recruiting |
Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 2, Therapeutic Exploratory Study) |
- Erosive Gastroesophageal Reflux Disease
|
- Drug: DWP14012
- Drug: Esomeprazole
- Drug: DWP14012 placebo
- Drug: Esomeprazole placebo
|
Interventional |
Phase 2 |
- Daewoong Pharmaceutical Co. LTD.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Ratio of subjects who were completely cured of mucosal defects by 8 weeks
- Ratio of subjects who were completely cured of mucosal defects by 4 weeks
|
208 |
All |
20 Years to 75 Years (Adult, Senior) |
NCT03184324 |
DW_DWP14012002 |
|
August 2017 |
March 2018 |
March 2018 |
June 12, 2017 |
August 23, 2017 |
|
- Hanyang University Medical Center
Sungdogu, Seoul, Korea, Republic of
|
| 10 |
NCT00260572 |
Recruiting |
Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease |
- Gastroesophageal Reflux Disease
|
- Behavioral: Questionnaires to evaluate QOL
- Behavioral: Questionnaires to evaluate heartburn and quality of life
- Behavioral: Questionnaire to evaluate satisfaction with treatment
- Behavioral: Questionnaire to evaluate presence or absence of pain
|
Observational |
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
|
2500 |
All |
18 Years and older (Adult, Senior) |
NCT00260572 |
#99-0355 |
|
April 1999 |
December 2050 |
December 2050 |
December 1, 2005 |
July 18, 2017 |
|
- UPMC Department of Cardiothoracic Surgery
Pittsburgh, Pennsylvania, United States
|
| 11 |
NCT03390634 |
Not yet recruiting |
Physiological Predictors of Clinical Outcomes After Anti-reflux Surgery |
|
- Other: Gastroesophageal reflux symptoms questionnaires
|
Observational |
|
- Guy's and St Thomas' NHS Foundation Trust
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Reflux Disease Questionnaire (RDQ) score improvement ratio after anti-reflux surgery
- Reflux Symptoms Index (RSI) threshold score after anti-reflux surgery
- Gastroesophageal Reflux Disease Health-Related Quality of Life (GORD-HRQL) threshold scores after anti-reflux surgery
- (and 2 more...)
|
350 |
All |
18 Years and older (Adult, Senior) |
NCT03390634 |
238959 |
|
March 15, 2018 |
September 15, 2018 |
September 15, 2018 |
January 4, 2018 |
January 9, 2018 |
|
|
| 12 |
NCT03341585 |
Not yet recruiting |
Influence of Expiration Lente Prolongée on Gastro-oesophageal Reflux |
|
- Other: expiration lente prolongée
|
Interventional |
Not Applicable |
- Vrije Universiteit Brussel
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
50 |
All |
up to 365 Days (Child) |
NCT03341585 |
FVG005 |
|
May 1, 2018 |
January 1, 2021 |
January 1, 2021 |
November 14, 2017 |
March 2, 2018 |
|
|
| 13 |
NCT03407456 |
Not yet recruiting |
Correlations Between Wireless pH Monitoring and Variation in Reflux Symptom Questionnaire, 7 Day Recall |
|
- Other: Gastroesophageal reflux symptoms questionnaire
|
Observational |
|
- Guy's and St Thomas' NHS Foundation Trust
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Reflux Symptom Questionnaire-7-day recall (RESQ-7) scores at 4 weeks on treatment with PPIs
- Comparison of RESQ-7 scores at 4 weeks and 8 weeks
- Overall change in RESQ-7 scores from baseline.
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03407456 |
236758 |
|
April 15, 2018 |
October 15, 2018 |
October 15, 2018 |
January 23, 2018 |
February 20, 2018 |
|
|
| 14 |
NCT03357809 |
Recruiting |
Endoscopic Resection in Gastro-Esophageal Reflux Disease |
- GERD
- Gastro Esophageal Reflux
|
- Procedure: Endoscopic mucosal resection
|
Interventional |
Not Applicable |
- Hospital St. Joseph, Marseille, France
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Rate of patients no longer requiring medical treatment at 6 months
- Improvement in quality of life
- Improvement of gastric PH
- Evaluation for morbidity
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT03357809 |
2016-A01591-50 |
RESECT-RGO |
April 10, 2017 |
April 10, 2019 |
April 10, 2023 |
November 30, 2017 |
November 30, 2017 |
|
- LAQUIERE
Marseille, France
|
| 15 |
NCT03259191 |
Recruiting |
Anti-reflux Mucosectomy (ARMS) is a Useful Therapy for Refractory Gastroesophageal Reflux Disease (RGERD) |
- Refractory Gastroesophageal Reflux Disease
|
- Procedure: anti-reflux mucosectomy
|
Interventional |
Not Applicable |
- Ruihua Shi
- Zhongda Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement of symptoms
- Complications of ARMS
|
20 |
All |
Child, Adult, Senior |
NCT03259191 |
GI of Zhongda |
|
August 20, 2017 |
November 20, 2017 |
August 31, 2020 |
August 23, 2017 |
August 23, 2017 |
|
- Zhongda Hospital Southeast University
Nanjing, Jiangsu, China
|
| 16 |
NCT02429830 |
Recruiting |
A Study of Reflux Management With the LINX® System for Gastroesophageal Reflux Disease After Laparoscopic Sleeve Gastrectomy |
- GERD
- Gastroesophageal Reflux Disease
|
|
Interventional |
Not Applicable |
- Torax Medical Incorporated
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in GERD-HRQL Score as a measure of efficacy
- Number of participants with serious complications as a measure of safety
- Change in total distal acid exposure as a measure of efficacy
- Change in PPI use as a measure of efficacy
|
30 |
All |
22 Years and older (Adult, Senior) |
NCT02429830 |
4600 |
RELIEF |
April 5, 2017 |
September 2019 |
September 2019 |
April 29, 2015 |
March 8, 2018 |
|
- Southern Arizona Centers for Minimally Invasive Surgery
Tucson, Arizona, United States - Mercy Health Northwest Arkansas
Rogers, Arkansas, United States - Surgical Specialists of Louisiana
Metairie, Louisiana, United States - (and 3 more...)
|
| 17 |
NCT02584751 |
Recruiting |
GERD and Anti-Reflux Therapy Between Able-bodied and SCI Individuals |
- Gastro Esophageal Reflux Disorder
|
- Drug: Omeprazole
- Device: 24 Hour pH Monitor
- Procedure: Pulmonary Function Examination
- (and 4 more...)
|
Interventional |
Phase 1 |
- James J. Peters Veterans Affairs Medical Center
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- DeMeester Score
- Pulmonary Function Tests
- Symptom Surveys and Questionnaires
|
110 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02584751 |
RAD-16-02 |
|
August 2016 |
August 2018 |
|
October 23, 2015 |
November 15, 2016 |
|
- James J. Peters VA Medical Center
Bronx, New York, United States
|
| 18 |
NCT01682265 |
Recruiting |
Stretta In Reflux Uncontrolled by IPP |
- Gastroesophageal Reflux Disease
|
- Other: Stretta procedure
- Other: Sham procedure
|
Interventional |
Not Applicable |
- Nantes University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Efficiency of the treatment 6 months post-procedure
- Effects on digestive symptoms
- Necessity of IPP treatment
- (and 6 more...)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT01682265 |
BRD/11/06-Q |
SIRUP |
March 26, 2012 |
October 2018 |
May 2019 |
September 10, 2012 |
January 24, 2018 |
|
- Nantes Universitary Hospital
Nantes, Loire Atlantique, France - Bordeaux Universitary Hospital
Bordeaux, France - Brest universitary hospital
Brest, France - (and 3 more...)
|
| 19 |
NCT02437682 |
Recruiting |
Translation and Validation of the PASS Test for GERD Patients With Partial Response to PPI in Chinese Population: PASS-C |
- Gastro-esophageal Reflux Disease
|
|
Observational |
|
- Chinese University of Hong Kong
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02437682 |
PASS-C |
|
January 2017 |
December 2017 |
December 2017 |
May 7, 2015 |
April 21, 2017 |
|
- Prince of Wales Hospital
Hong Kong, Hong Kong
|
| 20 |
NCT02788591 |
Recruiting |
Confocal Endomicroscopy for Non-Erosive Reflux Disease Detection |
- Non-erosive Reflux Disease
- Gastroesophageal Reflux
|
- Drug: Proton Pump Inhibitor (PPI) Therapy
- Drug: Sucralfate
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Evaluate non erosive reflux disease (NERD) Symptoms.
- Evaluate the role of probe based endomicroscopy in the diagnosis of NERD by evaluating dilated intercellular spaces, evaluation of IPCL, and quantification of fluorescein leak.
- Compare quality of life in patients with NERD.
- Compare two medications within each NERD study groups as a subgroup analysis.
|
140 |
All |
18 Years and older (Adult, Senior) |
NCT02788591 |
CENERDD |
CENERDD |
August 2015 |
December 2017 |
June 2018 |
June 2, 2016 |
July 29, 2016 |
|
- Ochsner Health System
Kenner, Louisiana, United States
|
| 21 |
NCT03014453 |
Recruiting |
Is Gastroesophageal Reflux Really a Potential Risk for the Late Complications of Bronchopulmonary Dysplasia in Extremely Premature Infants? |
- Gastroesophageal Reflux
- Bronchopulmonary Dysplasia
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- prevalence of late complications
|
100 |
All |
up to 30 Weeks (Child) |
NCT03014453 |
A333-1 |
|
January 2017 |
May 2018 |
June 2018 |
January 9, 2017 |
June 5, 2017 |
|
- Shengjing Hospital
Shenyang, Liaoning, China
|
| 22 |
NCT02806453 |
Not yet recruiting |
Effect of Magnesium Alginate on Gastroesophageal Reflux in Infants. |
|
- Dietary Supplement: thickened formula
- Dietary Supplement: Mg alginate
- Behavioral: reassurance with lifestyle changes
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Evaluation of symptom scores
|
99 |
All |
3 Months to 1 Year (Child) |
NCT02806453 |
ALNEO1 |
|
July 2016 |
July 2017 |
December 2017 |
June 20, 2016 |
June 21, 2016 |
|
- Dept Of Obstetrics and Neonatology - Section of Neonatology University of Bari Policlinico Hospital
Bari, Italy
|
| 23 |
NCT02506634 |
Recruiting |
The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Department |
|
- Drug: Esomeprazole MUPS, 20 mg
|
Observational |
|
- First Affiliated Hospital, Sun Yat-Sen University
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- the primary symptom of GERD in Chinese outpatients in Gastroenterology department
- The percentage of each symptom of GERD
- The life quality of GERD patients
- the sensitivity and specificity of either GERD Q or 4-week PPI test for diagnosis of GERD
|
300 |
All |
18 Years to 65 Years (Adult) |
NCT02506634 |
ESR-14-10521 |
|
August 2015 |
September 2017 |
September 2017 |
July 23, 2015 |
January 18, 2017 |
|
- the first affiliated hospital of SYSU
Guangzhou, Guangdong, China
|
| 24 |
NCT02486263 |
Recruiting |
Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial |
- Gastroesophageal Reflux Disease
|
|
Interventional |
Not Applicable |
- Sudarshan Jadcherla
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Ohio State University
- Nationwide Children's Hospital
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Feeding Success
- Mechanisms of Aerodigestive Safety
- Growth Outcome Measures
- (and 2 more...)
|
120 |
All |
34 Weeks to 60 Weeks (Child) |
NCT02486263 |
11-00734
R01DK068158 |
GMT |
December 2012 |
March 31, 2019 |
March 31, 2019 |
July 1, 2015 |
March 13, 2018 |
|
- The Research Institute at Nationwide Children's Hospital
Columbus, Ohio, United States
|
| 25 |
NCT02984930 |
Not yet recruiting |
Effect of Proton Pump Inhibitor and Mosapride on Acid Pocket in Gastroesophageal Reflux Disease |
- Gastroesophageal Reflux Disease
|
- Drug: Administration of study drug (esomeprazole, mosapride)
- Drug: Administration of study drug (esomeprazole, placebo tablet)
- Procedure: upper endoscopy, scintigraphy
|
Interventional |
Not Applicable |
- Gangnam Severance Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Size(cm2) of the acid pocket between PPI+placebo group and PPI+mosapride group
- Location(cm) of the acid pocket between PPI+placebo group and PPI+mosapride group
- Improvement of reflux symptom
|
30 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02984930 |
3-2016-0071 |
|
December 2016 |
July 2018 |
July 2018 |
December 7, 2016 |
December 7, 2016 |
|
|
| 26 |
NCT03306485 |
Recruiting |
Post Prandial High Resolution Impedance- Manometry |
|
- Other: Correlating the number of reflux episodes detected on 1-h post prandial esophageal high resolution manometry combined and those detected on ambulatory 24-h pH-impedance monitoring performed on PPI
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- High Resolution Impedance Manometry
- 24-h pH-impedance
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT03306485 |
69HCL17_0427 |
|
December 21, 2017 |
May 21, 2019 |
May 21, 2019 |
October 11, 2017 |
January 11, 2018 |
|
- Exploration Fonctionnelle Digestive, Hôpital Edouard Herriot, Lyon, France
Lyon, France
|
| 27 |
NCT03097887 |
Not yet recruiting |
Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures |
|
- Procedure: Omega Loop Gastric Bypass
- Device: Bilitec 2000™
- Device: V-Loc
|
Interventional |
Not Applicable |
- Medical University of Vienna
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Diagnostic
|
- Bile Reflux
- Inflammation
- Weight loss
- (and 7 more...)
|
100 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT03097887 |
1640/2016 |
|
October 1, 2018 |
July 1, 2019 |
July 1, 2020 |
March 31, 2017 |
March 27, 2018 |
|
|
| 28 |
NCT02743949 |
Recruiting |
Comparison of Vonoprazan to Esomeprazole in Participants With Symptomatic GERD Who Responded Partially to a High Dose of Proton Pump Inhibitor (PPI) |
|
- Drug: Vonoprazan
- Drug: Esomeprazole
- Drug: Esomeprazole Placebo
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percentage of Heartburn-Free 24 Hour Periods (Day and Night) During 4 Weeks of Treatment
- Percentage of Participants with ≥1 Sustained Resolution of Heartburn During the 4-Week Treatment Period
|
213 |
All |
18 Years and older (Adult, Senior) |
NCT02743949 |
Vonoprazan-2001
U1111-1172-2373
2015-001154-14
16/LO/0285 |
|
July 14, 2016 |
June 29, 2018 |
July 6, 2018 |
April 19, 2016 |
February 19, 2018 |
|
- Medif
Gozee, Belgium - SPRL Dr Yvan CALOZET
Grigomont, Belgium - UZ Leuven
Leuven, Belgium - (and 36 more...)
|
| 29 |
NCT03130543 |
Recruiting |
A Trial of Thickened Feeds to Treat Gastroesophageal Reflux in Children Admitted After Choking Spell |
- Apparent Life Threatening Event
- Gastroesophageal Reflux
- Aspiration
|
- Dietary Supplement: Rice cereal
- Dietary Supplement: Enfamil AR
|
Interventional |
Not Applicable |
- Boston Children’s Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Choking episodes
- Repeat hospital admission
- Microbiome changes
- Urine concentration
|
120 |
All |
up to 1 Year (Child) |
NCT03130543 |
IRB-P00023342 |
|
April 24, 2017 |
March 6, 2022 |
March 6, 2022 |
April 26, 2017 |
April 26, 2017 |
|
- Boston Children's Hospital
Boston, Massachusetts, United States
|
| 30 |
NCT02797756 |
Recruiting |
Impact of Gastroesophageal Reflux and Aspiration on Airway Inflammation and Microbiome in Children With Chronic Cough |
- Chronic Cough (CC)
- Gastroesophageal Reflux (GER)
|
- Procedure: Esophago-gastro-duodenoscopy (EGD) with biopsy
- Procedure: Esophageal Impedance Monitoring (EIM)
|
Observational |
|
- New York University School of Medicine
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Comparison of Reflux Finding Score (RFS) in CC/GER- group and CC/GER+ group
- Comparison of bronchoscopic secretions scoring system (BSSS) in CC/GER- group and CC/GER+ group
|
120 |
All |
up to 24 Years (Child, Adult) |
NCT02797756 |
14-01021 |
|
June 2014 |
December 2018 |
December 2018 |
June 13, 2016 |
March 6, 2018 |
|
- New York University School of Medicine
New York, New York, United States
|
| 31 |
NCT02533349 |
Recruiting |
Trial of Proton Pump Inhibitor With Prokinetics or Placebo in Patients With Laryngopharyngeal Reflux Disease |
- Laryngopharyngeal Reflux Disease
|
- Drug: Motilitone
- Drug: Pantoprazole
- Drug: Placebo
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Reflux symptom index (questionnaire)
- Reflux finding score (scoring of laryngeal stroboscopy finding score)
|
200 |
All |
20 Years to 65 Years (Adult) |
NCT02533349 |
2015-05-007-001 |
|
May 2016 |
December 2016 |
January 2017 |
August 26, 2015 |
June 1, 2016 |
|
- Samsung Medical Center
Seoul, Korea, Republic of
|
| 32 |
NCT02081404 |
Recruiting |
Diagnosis of Acid Reflux Disease Using Novel Imaging: A Prospective Study |
- Non-erosive Reflux Disease
|
- Drug: Esomeprazole
- Drug: Placebo
|
Interventional |
Not Applicable |
- Midwest Biomedical Research Foundation
- Kansas City Veteran Affairs Medical Center
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Participant)
- Primary Purpose: Diagnostic
|
- NBI endoscopy identifies changes in the distal esophagus that are specific for diagnosing patients with Non-Esophageal Reflux Disease.
|
126 |
All |
18 Years and older (Adult, Senior) |
NCT02081404 |
3155105 |
|
March 2011 |
December 2018 |
December 2018 |
March 7, 2014 |
January 18, 2018 |
|
- Department of Veterans Affairs Medical Center
Kansas City, Missouri, United States - Queen Medical Center
Nottingham, United Kingdom
|
| 33 |
NCT03463395 |
Not yet recruiting |
Efficacy of Reza Band for the Treatment of Laryngopharyngeal Reflux |
|
|
Interventional |
Not Applicable |
- Medical College of Wisconsin
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Tissue and Salivary Pepsin Levels
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT03463395 |
PRO30948 |
|
April 2018 |
November 2019 |
November 2019 |
March 13, 2018 |
March 13, 2018 |
|
|
| 34 |
NCT00367159 |
Recruiting |
Evaluation of the Efficiency of Autologous Adipocytes Graft in Endoscopic Treatment in Vesico-Renal Reflux in Children |
|
- Procedure: endoscopic treatment of vesico-renal reflux
|
Interventional |
Phase 3 |
- University Hospital, Strasbourg, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Realization of an urethrocystography
- Clinical or biological diagnosis of a pyelonephritis during the follow up (10 years)
|
14 |
All |
3 Years to 15 Years (Child) |
NCT00367159 |
3490
TC 197 |
|
January 2007 |
August 2020 |
February 2021 |
August 22, 2006 |
February 25, 2009 |
|
- Service de Chirurgie Infantile, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg
Strasbourg, France
|
| 35 |
NCT02087345 |
Recruiting |
Gastro-oesophageal Reflux in Oligosymptomatic Patients With Dental Erosion |
- Dental Erosion
- Gastroesophageal Reflux
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The % of time with pH<4 and 5.5 during 24-hour pH-impedance
- The number of acidic and weakly acidic reflux episodes during 24-hour pH-impedance
|
500 |
All |
18 Years and older (Adult, Senior) |
NCT02087345 |
BGRG-2414b |
|
March 2014 |
December 2018 |
June 2019 |
March 14, 2014 |
August 7, 2017 |
|
- Gastroenterology Group Practice
Bern, Switzerland
|
| 36 |
NCT02892357 |
Not yet recruiting |
Efficacy of Traditional Chinese Medicine Combined With Omeprazole in Patients With Non-erosive Reflux Disease |
- Non-erosive Reflux Disease
|
- Drug: Jianpi Qinghua Recipe
- Drug: omeprazole
|
Interventional |
Phase 2 |
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change of Gastroesophageal Reflux Disease Questionnaire (GERD Q)
- Change of SF-36 questionnaire
|
204 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02892357 |
Digestion-04 |
|
January 2017 |
December 2018 |
December 2018 |
September 8, 2016 |
September 20, 2016 |
|
- Dong Fang Hospital
Beijing, Beijing, China - Guang'An Men Hospital
Beijing, Beijing, China
|
| 37 |
NCT02685150 |
Recruiting |
Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease |
- Gastroesophageal Reflux Disease
- Dyspepsia
- Bile Reflux
|
- Device: Endoscopic Tri-Modal Imaging
- Drug: Omeprazole
- Other: Analysis of gastric juice
|
Interventional |
Not Applicable |
- Chinese PLA General Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Numbers of participants with abnormal endoscopic findings and positive Omeprazole tests
|
200 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02685150 |
S2015-086-02 |
|
January 2016 |
January 2018 |
January 2020 |
February 18, 2016 |
February 22, 2016 |
|
- Chinese PLA General Hospital
Beijing, China
|
| 38 |
NCT03436914 |
Not yet recruiting |
Treatment Response of Maintenance Dose of Proton Pump Inhibitor in Patients With Nonerosive Gatroesophageal Reflux Disease |
- Non-erosive Gatroesophageal Reflux Disease
|
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of PAGI-SYM score (0-2) patients after 8 weeks of PPI(Esomezol)
- The analysis of factors affecting the PAGI-SYM inculding immunolgic array and esophagus mucosal microbiota
|
62 |
All |
19 Years to 80 Years (Adult, Senior) |
NCT03436914 |
4-2017-1143 |
|
March 1, 2018 |
January 20, 2020 |
January 20, 2020 |
February 19, 2018 |
February 20, 2018 |
|
- Yonsei university College of Medicine
Seoul, Korea, Republic of
|
| 39 |
NCT03228407 |
Recruiting |
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD) |
- Gastro Esophageal Reflux
- Barrett Esophagus
- Erosive Esophagitis
|
- Procedure: Confocal endomicroscopy
- Diagnostic Test: Endoscopic biopsies
- Diagnostic Test: Mucosal impedance (MI)
|
Interventional |
Not Applicable |
- McGuire Research Institute
- Hunter Holmes McGuire VA Medical Center
|
Other / U.S. Fed |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Diagnostic
|
- Correlation between the time from intravenous injection of fluorescein to visualization of fluorescein on probe based confocal endomicroscopy (pCLE) with esophageal permeability (i.e. - epithelial barrier function).
- Compare the time from intravenous injection of fluorescein to visualization of fluorescein on probe based confocal endomicroscopy (pCLE) in patients with Barrett's esophagus and controls
- Compare the time from intravenous injection of fluorescein to visualization of fluorescein on probe based confocal endomicroscopy (pCLE) in patients with symptoms of refractory GERD and Barrett's esophagus
- (and 3 more...)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT03228407 |
2282 |
|
April 28, 2017 |
June 2018 |
June 2018 |
July 24, 2017 |
January 16, 2018 |
|
- Hunter Holmes McGuire VA Medical Center
Richmond, Virginia, United States
|
| 40 |
NCT03015610 |
Recruiting |
Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma |
- Asthma
- Gastroesophageal Reflux
|
- Drug: commercially available lansoprazole
- Drug: matched placebo
|
Interventional |
Phase 3 |
- Jason Lang, M.D., M.P.H.
- Thrasher Research Fund
- Nemours Children's Clinic
- Duke University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in Asthma Control Questionnaire (ACQ) from Screening through Week 26
- Change in GERD Symptom Assessment Questionnaire Score (GSAS) from Screening through Week 26
- Change in Asthma Symptom Utility Index (ASUI) from Screening through Week 26
- (and 4 more...)
|
110 |
All |
6 Years to 17 Years (Child) |
NCT03015610 |
Pro00079073 |
GenARA |
October 31, 2017 |
August 2020 |
August 2020 |
January 10, 2017 |
January 30, 2018 |
|
- Nemours Children's Specialty Care
Jacksonville, Florida, United States - Duke University Medical Center
Durham, North Carolina, United States
|
| 41 |
NCT02986685 |
Recruiting |
Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole |
- Refractory Reflux Esophagitis
|
- Drug: Trimebutine Maleate
- Drug: rabeprazole
|
Interventional |
Phase 4 |
- Xijing Hospital of Digestive Diseases
- Ankang City Central Hospital
- Shaanxi Provincial People's Hospital
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The change of main symptom （heartburn，acid regurgitation，non-cardiac chestpain，hoarseness，et，al）score from baseline to the end of 8 weeks
- The change of main symptom （heartburn，acid regurgitation，non-cardiac chestpain，hoarseness，et，al）score from the end of 8 weeks to the end of 12 weeks
- change of GerdQ score from baseline to the end of 8 weeks
- (and 11 more...)
|
500 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02986685 |
KY-20162096-1 |
rRE |
November 2016 |
October 2017 |
November 2017 |
December 8, 2016 |
December 8, 2016 |
|
- Xijing Hosipital of Digestive Disease
Xi`an, Shaanxi, China
|
| 42 |
NCT03418350 |
Not yet recruiting |
The Role of Laryngopharyngeal Reflux in IPF |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The supraglottic index (SGI) quantifies laryngopharyngeal reflux (LPF) and is associated with severity of pulmonary fibrosis.
|
60 |
All |
40 Years to 95 Years (Adult, Senior) |
NCT03418350 |
HS-3130 |
|
February 2018 |
December 2020 |
December 2020 |
February 1, 2018 |
February 2, 2018 |
|
- National Jewish Health
Denver, Colorado, United States
|
| 43 |
NCT02749071 |
Recruiting |
An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Reflux |
- Gastroesophageal Reflux Disease (GERD)
- Reflux, Gastroesophageal
- Gastroesophageal Reflux
- Acid Reflux
|
- Procedure: Laparoscopic implantation surgery
- Device: EndoStim stimulation for first six months of study
- Device: EndoStim stimulation from Month 6 thru end of study
- Device: Sham EndoStim stimulation for first six months of study
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Rate of device and/or procedure-related serious adverse events
- Percentage of subjects achieving pH success (pH<4 for mo more than 5.3% of time or at least 50% improvement in pH compared to baseline)
|
110 |
All |
22 Years to 75 Years (Adult, Senior) |
NCT02749071 |
CS-100 |
|
May 2016 |
March 2018 |
December 2021 |
April 22, 2016 |
January 24, 2018 |
|
- St. Joseph's Hospital and Medical Center
Phoenix, Arizona, United States - HonorHealth Research Institute
Scottsdale, Arizona, United States - University of Southern California (USC)
Los Angeles, California, United States - (and 19 more...)
|
| 44 |
NCT03068572 |
Recruiting |
Diagnostic Value of Linked Color Imaging for Minimal Change Esophagitis in Nonerosive Reflux Esophagitis and GERD |
- Gastroesophageal Reflux Disease
- Minimal Change Disease
- Non-Reflux Esophagitis
|
|
Observational |
|
- Affiliated Hospital to Academy of Military Medical Sciences
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- observation minimal change esophagitis
- Improvement observation agreement of Los Angeles classification system for GERD using LCI by comparing with that under white endoscopy
|
90 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03068572 |
307LCI-MCE |
|
January 15, 2017 |
October 30, 2017 |
December 30, 2017 |
March 3, 2017 |
September 19, 2017 |
|
- Department of gastroenterology,Affiliated Hospital to Academy of Military Medical Sciences
Beijing, Beijing, China
|
| 45 |
NCT03495219 |
Not yet recruiting
New |
Can Individuals Control Pressure in Their Esophagus. |
|
- Procedure: Esophageal Manometry
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Reduction in Reflux Symptom Index Score (RSI)
- Association of RSI to resting manometry pressure in the lower esophagus
- Can lower esophageal pressure can be increased by instruction/coaching by a physical therapist.
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03495219 |
17-003796 |
manometry |
May 1, 2018 |
July 30, 2018 |
July 30, 2018 |
April 11, 2018 |
April 11, 2018 |
|
- Mayo Clinic in Florida
Jacksonville, Florida, United States
|
| 46 |
NCT03417817 |
Not yet recruiting |
Oesophageal Acid Exposure in Healthy Subjects Over 96 Hours |
|
|
Interventional |
Not Applicable |
- Guy's and St Thomas' NHS Foundation Trust
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Acid exposure time in 4 days/96 hours
- Acid exposure time in 3 days/72 hours
- Percent total time pH < 4 for each 24-hour period
- (and 6 more...)
|
25 |
All |
18 Years to 65 Years (Adult) |
NCT03417817 |
227671 |
|
March 15, 2018 |
September 15, 2018 |
September 15, 2018 |
January 31, 2018 |
January 31, 2018 |
|
|
| 47 |
NCT03226054 |
Recruiting |
Determining Risk Factors for Successful PPI Weaning |
|
- Behavioral: Lifestyle Modifications
|
Interventional |
Not Applicable |
- Mount Carmel Health System
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Successful Weaning off a Proton Pump Inhibitor
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03226054 |
160809-6 |
|
September 1, 2016 |
August 31, 2018 |
August 31, 2019 |
July 21, 2017 |
July 21, 2017 |
|
- Mount Carmel St. Ann's Family Medicine Center
Westerville, Ohio, United States
|
| 48 |
NCT02794844 |
Recruiting |
Implementation of PPI Medication PGX Testing |
|
- Genetic: Genotype Guided Dosing
|
Interventional |
Phase 4 |
- Nemours Children's Clinic
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percent of patients agreeing to volunteer for the study
- Percent of patients reporting efficacy and toxicity data
- Percent of providers agreeing to participate in study
- (and 3 more...)
|
120 |
All |
2 Years to 17 Years (Child) |
NCT02794844 |
744230 |
PGX |
March 2016 |
January 2018 |
January 2018 |
June 9, 2016 |
June 9, 2016 |
|
- Nemours Children's Hospital
Orlando, Florida, United States
|
| 49 |
NCT02783378 |
Not yet recruiting |
48 Hours Esophagal pH-monitoring With and Without Gaviscon |
|
|
Interventional |
Not Applicable |
- Universitair Ziekenhuis Brussel
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Incidence of pathological GERD
- Effect of Gaviscon on pain in infants with GERD
- Effect of Gaviscon on parental concern for parents of infants with GERD
|
25 |
All |
up to 6 Years (Child) |
NCT02783378 |
B.U.N. 143201627026 |
|
May 2016 |
December 2016 |
May 2017 |
May 26, 2016 |
May 26, 2016 |
|
|
| 50 |
NCT00574327 |
Recruiting |
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry |
- Barrett's Esophagus
- Gastroesophageal Reflux Disease
- Esophageal Adenocarcinoma
|
|
Observational |
|
- Midwest Biomedical Research Foundation
- Kansas City Veteran Affairs Medical Center
|
Other / U.S. Fed |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- The goal of this study is to follow GERD and BE pts prospectively for development of dysplasia and adenocarcinoma, to identify factors responsible for progression of GERD to BE to dysplasia and adenocarcinoma.
- The secondary goal is to create a tissue and serum repository for future biomarker studies.
|
3000 |
All |
18 Years and older (Adult, Senior) |
NCT00574327 |
PS0035 |
|
January 2006 |
October 2019 |
January 2020 |
December 17, 2007 |
May 30, 2017 |
|
- Department of Veterans Affairs Medical Center
Kansas City, Missouri, United States
|
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