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48 studies found for:    Open Studies | "Down Syndrome"
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Rank Status Study
21 Recruiting Comparison of Bispectral Index Values in Patients With and Without Down's Syndrome
Condition: Down Syndrome
Intervention: Device: monitoring BIS in both groups
22 Recruiting Investigation of the Safety of Intranasal Glulisine in Down Syndrome
Condition: Down Syndrome
Interventions: Drug: Insulin glulisine;   Drug: Saline
23 Not yet recruiting Relationship Between Down Syndrome (DS) and Alzheimer's Disease (AD)
Conditions: Down Syndrome;   Alzheimer's Dementia
Interventions: Procedure: biospecimen collection;   Other: cognitive assessments;   Other: caregiver questionnaire;   Procedure: Florbetapir F18 imaging;   Procedure: MRI;   Procedure: Fludeoxyglucose F18 (FDG);   Procedure: Tau Pet;   Procedure: Actigraphy
24 Not yet recruiting Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome
Conditions: Down Syndrome;   Polyendocrinopathies, Autoimmune;   Respiratory Tract Infections;   Autoimmunity
Intervention: Other: Phlebotomy
25 Recruiting Safety, Tolerability and Immunogenicity of ACI-24 Vaccine in Adults With Down Syndrome
Condition: Down Syndrome
Interventions: Biological: ACI-24 low dose;   Biological: ACI-24 high dose;   Biological: Placebo
26 Recruiting A Pilot Study to Evaluate the Safety and Efficacy of the Hypoglossal Nerve Stimulator in Adolescents With Down Syndrome and Obstructive Sleep Apnea
Conditions: Sleep Apnea, Obstructive;   Down Syndrome
Intervention: Device: Inspire® Upper Airway Simulation System, Model 3024 IPG, and any subsequent iteration thereof that are approved under P130008 for the treatment of obstructive sleep apnea
27 Unknown  Frequency of Metabolic Syndrome in Down Syndrome Patients
Conditions: Metabolic Syndrome X;   Down Syndrome
28 Recruiting Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
Conditions: Down Syndrome;   Fetal Aneuploidy
29 Recruiting Non-Invasive Chromosomal Evaluation of Trisomy Study
Conditions: Aneuploidy;   Trisomy 21;   Trisomy 18;   Trisomy 13;   Down Syndrome
30 Recruiting Digital Dysmorphology Project
Condition: Down Syndrome
Intervention: Device: photographs
31 Recruiting The Human Trisome Project Biobank
Conditions: Down Syndrome;   Trisomy 21
32 Recruiting Expanded Noninvasive Genomic Medical Assessment: The Enigma Study
Conditions: Down Syndrome;   Edwards Syndrome;   Patau Syndrome;   Klinefelter Syndrome;   Turner Syndrome;   DiGeorge Syndrome;   Chromosome Deletion;   Aneuploidy
Intervention: Other: Blood sampling for Laboratory Developed Test (LDT) analysis
33 Recruiting Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies
Conditions: Down Syndrome;   Aneuploidy
Intervention: Other: Maternal blood draw of 30 to 50ml
34 Recruiting Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
Conditions: Alzheimer Disease;   Down Syndrome;   Mild Cognitive Impairment
35 Recruiting Weight Management for Adolescents With IDD
Conditions: Developmental Disabilities;   Weight Loss;   Body Weight;   Down Syndrome;   Body Weight Changes;   Intellectual Disability
Interventions: Dietary Supplement: Enhanced Stop Light Diet (eSLD);   Dietary Supplement: Conventional Diet (CD);   Behavioral: Face-to-face (FTF);   Behavioral: Technology (TECH);   Other: iPad with FaceTime
36 Recruiting Whole Blood Specimen Collection From Pregnant Subjects
Conditions: Down Syndrome;   Edwards Syndrome;   Patau Syndrome;   Klinefelter Syndrome;   Turner Syndrome;   DiGeorge Syndrome;   Perinatal Infections
Intervention: Other: Observational - no intervention
37 Recruiting Non-Invasive Screening for Fetal Aneuploidy
Conditions: Down Syndrome;   Edwards Syndrome
Intervention: Other: Maternal Blood Draw
38 Recruiting Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma
Conditions: Adult B Lymphoblastic Lymphoma;   Childhood B Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1;   Childhood B Lymphoblastic Lymphoma;   Down Syndrome;   Stage I B Lymphoblastic Lymphoma;   Stage II B Lymphoblastic Lymphoma;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Thioguanine;   Drug: Vincristine Sulfate
39 Recruiting DIR/ Floortime™ Parent Training Intervention for the Children With Developmental Disabilities
Conditions: Cerebral Palsy;   Down's Syndrome;   Delayed Development
Interventions: Behavioral: Parent training;   Behavioral: Routine care
40 Unknown  Non-Invasive Determination of Fetal Chromosome Abnormalities
Conditions: Down Syndrome (Trisomy 21);   Edward's Syndrome (Trisomy 18);   Patau Syndrome (Trisomy 13);   Klinefelter Syndrome (47, XXY);   and Other Chromosome;   Abnormalities.

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