40 studies found for:    Open Studies | "Down Syndrome"
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Rank Status Study
21 Recruiting Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies
Conditions: Down Syndrome;   Aneuploidy
Intervention: Other: Maternal blood draw of 30 to 50ml
22 Not yet recruiting Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome
Conditions: Down Syndrome;   Polyendocrinopathies, Autoimmune;   Respiratory Tract Infections;   Autoimmunity
Intervention: Other: Phlebotomy
23 Recruiting The Crnic Institute Human Trisome Project Biobank
Conditions: Down Syndrome;   Trisomy 21
Intervention:
24 Recruiting Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
Conditions: Down Syndrome;   Fetal Aneuploidy
Intervention:
25 Recruiting Diagnosis Accuracy of Noninvasive Screening by PCR Digital for Down Syndrom
Condition: Trisomy 21
Intervention: Genetic: Diagnostic
26 Recruiting Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome
Conditions: Childhood Acute Myeloid Leukemia;   Childhood Myelodysplastic Syndrome;   Cytopenia;   Down Syndrome;   Myeloid Leukemia Associated With Down Syndrome;   Myeloproliferative Neoplasm
Interventions: Drug: Asparaginase;   Drug: Asparaginase Erwinia chrysanthemi;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mitoxantrone Hydrochloride;   Drug: Thioguanine
27 Recruiting Non-Invasive Screening for Fetal Aneuploidy
Conditions: Down Syndrome;   Edwards Syndrome
Intervention: Other: Maternal Blood Draw
28 Recruiting Obstructive Sleep Apnea and Down Syndrome: Clinical Examination Issue
Condition: Obstructive Sleep Apnea
Intervention: Other: Sleep Symptom
29 Recruiting DIR/ Floortime™ Parent Training Intervention for the Children With Developmental Disabilities
Conditions: Cerebral Palsy;   Down's Syndrome;   Delayed Development
Interventions: Behavioral: Parent training;   Behavioral: Routine care
30 Recruiting Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
Conditions: Alzheimer Disease;   Down Syndrome;   Mild Cognitive Impairment
Intervention:
31 Recruiting Non-Invasive Chromosomal Evaluation of Trisomy Study
Conditions: Aneuploidy;   Trisomy 21;   Trisomy 18;   Trisomy 13;   Down Syndrome
Intervention:
32 Recruiting High Risk Multiple Gestation Study
Conditions: Trisomy 13;   Trisomy 18;   Trisomy 21;   Sex Chromosome Abnormalities
Intervention:
33 Recruiting Multiple Gestation Study
Conditions: Trisomy 13;   Trisomy 18;   Trisomy 21;   Sex Chromosome Abnormalities
Intervention:
34 Recruiting Development of Non-invasive Prenatal Test for Microdeletion and Other Genetic Syndromes Based on Cell Free DNA
Conditions: Microdeletion Syndromes;   Trisomy 21;   Trisomy 18;   Trisomy 13;   Sex Chromosome Abnormalities
Intervention:
35 Recruiting Development of Non-invasive Prenatal Screening Test for Microdeletions Based on Fetal DNA Isolated From Maternal Blood
Conditions: Trisomy 21;   Trisomy 18;   Trisomy 13;   Sex Chromosome Abnormalities;   Microdeletion Syndromes
Intervention:
36 Recruiting Expanded Noninvasive Genomic Medical Assessment: The Enigma Study
Conditions: Down Syndrome;   Edwards Syndrome;   Patau Syndrome;   Klinefelter Syndrome;   Turner Syndrome;   DiGeorge Syndrome;   Chromosome Deletion;   Aneuploidy
Intervention: Other: Blood sampling for Laboratory Developed Test (LDT) analysis
37 Recruiting Weight Management for Adolescents With IDD
Conditions: Developmental Disabilities;   Weight Loss;   Body Weight;   Down Syndrome;   Body Weight Changes;   Intellectual Disability
Interventions: Dietary Supplement: Enhanced Stop Light Diet (eSLD);   Dietary Supplement: Conventional Diet (CD);   Behavioral: Face-to-face (FTF);   Behavioral: Technology (TECH);   Other: iPad with FaceTime
38 Recruiting Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma
Conditions: Adult B Lymphoblastic Lymphoma;   Childhood B Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34;q11.2); BCR-ABL1;   Childhood B Lymphoblastic Lymphoma;   Down Syndrome;   Stage I B Lymphoblastic Lymphoma;   Stage II B Lymphoblastic Lymphoma;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Thioguanine;   Drug: Vincristine Sulfate
39 Recruiting Whole Blood Specimen Collection From Pregnant Subjects
Conditions: Down Syndrome;   Edwards Syndrome;   Patau Syndrome;   Klinefelter Syndrome;   Turner Syndrome;   DiGeorge Syndrome;   Perinatal Infections
Intervention: Other: Observational - no intervention
40 Recruiting SNP-based Microdeletion and Aneuploidy RegisTry (SMART)
Conditions: 22q11 Deletion Syndrome;   DiGeorge Syndrome;   Trisomy 21;   Trisomy 18;   Trisomy 13;   Monosomy X;   Sex Chromosome Abnormalities;   Cri-du-Chat Syndrome;   Angelman Syndrome;   Prader-Willi Syndrome;   1p36 Deletion Syndrome
Intervention:

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Study has passed its completion date and status has not been verified in more than two years.