| 1 |
NCT02925273 |
Recruiting |
Hand Grasping Techniques on Eliciting the Grasp Reflex in Patients With Dementia |
|
- Other: palmar grasp without dorsal stimulation
- Other: standard palmar grasp test with dorsal stimulation
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Grasp response
- Frontal Lobe release
- Frontal lobe release
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02925273 |
GRASP |
GRASP |
July 2016 |
December 2016 |
June 2017 |
October 5, 2016 |
October 5, 2016 |
|
- Rowan University School of Osteopathic Medicine
Stratford, New Jersey, United States
|
| 2 |
NCT03260608 |
Recruiting |
Effectiveness of a Psychoeducation and Support Protocol by Phone in the Aid of Caregivers of Patients With Dementia. |
|
|
Interventional |
Not Applicable |
- Hospital de Clinicas de Porto Alegre
- Federal University of Rio Grande do Sul
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change from baseline in the caregiver's level of burden
- Change from baseline in the caregivers's depressive symptoms
- Change from baseline in the caregivers's anxiety symptoms
- (and 3 more...)
|
148 |
Female |
18 Years and older (Adult, Senior) |
NCT03260608 |
17-0326 |
|
August 8, 2017 |
September 2018 |
January 2019 |
August 24, 2017 |
November 8, 2017 |
|
- Hospital de Clínicas de Porto Alegre
Porto Alegre, Brazil
|
| 3 |
NCT03152630 |
Recruiting |
Research on the Early and Prognosis Diagnosis of Vascular Dementia |
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Composite cardiovascular outcome
- With at least 1 cardiovascular risk factor.
|
600 |
All |
65 Years and older (Adult, Senior) |
NCT03152630 |
201512101RINA |
|
March 30, 2016 |
January 2036 |
January 2036 |
May 15, 2017 |
May 15, 2017 |
|
|
| 4 |
NCT03429686 |
Recruiting |
Digital Reminiscence for People With Dementia |
|
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Feasibility of the digital reminiscence therapy for PwD
- Acceptability of the digital reminiscence therapy for PwD
- Adherence to intervention
- (and 5 more...)
|
60 |
All |
Child, Adult, Senior |
NCT03429686 |
110-1709 |
DTR |
November 28, 2017 |
February 28, 2018 |
February 28, 2018 |
February 12, 2018 |
February 13, 2018 |
|
- University of Nottingham
Nottingham, United Kingdom
|
| 5 |
NCT02388711 |
Recruiting |
A Trial of the C-TraC Intervention for Dementia Patients |
|
- Other: C-TraC Intervention
|
Interventional |
Not Applicable |
- University of Wisconsin, Madison
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change from baseline in rehospitalizations at 14, 30 and 90-days
- Increase in patient delirium prevention/resolution
- Patient functional maintenance/recovery
- (and 2 more...)
|
1100 |
All |
65 Years and older (Adult, Senior) |
NCT02388711 |
2014-1221
2P50AG033514-06 |
|
March 2015 |
March 2019 |
March 2019 |
March 17, 2015 |
March 8, 2018 |
|
- University of Wisconsin Hospital
Madison, Wisconsin, United States
|
| 6 |
NCT02814422 |
Recruiting |
Triglyceride-rich Lipoprotein and Development of Dementia |
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Composite cardiovascular outcome
- With at least 1 cardiovascular risk factor.
|
1000 |
All |
65 Years and older (Adult, Senior) |
NCT02814422 |
201407002RIND |
|
July 2014 |
July 2017 |
July 2017 |
June 27, 2016 |
January 18, 2017 |
|
|
| 7 |
NCT02482623 |
Recruiting |
The Dementia Symptom Management at Home Program |
|
- Behavioral: Dementia Symptom Management at Home Program
|
Interventional |
Not Applicable |
- New York University
- Visiting Nurse Service of New York
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Supportive Care
|
- Person With Dementia Quality of Life
- Caregiver Quality of Life
- Person with Dementia Pain
- (and 5 more...)
|
150 |
All |
65 Years and older (Adult, Senior) |
NCT02482623 |
i14-01960 |
DSM-H |
August 1, 2017 |
March 1, 2018 |
May 31, 2018 |
June 26, 2015 |
September 13, 2017 |
|
- The New Jewish Home
New York, New York, United States - New York University College of Nursing
New York, New York, United States
|
| 8 |
NCT03167983 |
Recruiting |
Microbiome and Dementia |
|
|
Observational |
|
- Medical University of Graz
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Alpha diversity
- gut permeability
- bacterial translocation
- inflammation
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03167983 |
Demenz |
|
July 7, 2017 |
March 2018 |
December 2018 |
May 30, 2017 |
July 19, 2017 |
|
- Medical University of Graz
Graz, Austria
|
| 9 |
NCT03230071 |
Not yet recruiting |
Efficacy and Safety of TMBCZG in Mild to Moderate Vascular Dementia |
|
- Drug: TMBCZG
- Other: placebo
|
Interventional |
Phase 2 |
- Dongzhimen Hospital, Beijing
- Beijing Union pharmaceutical factory II
- Beijing Compete Medical Technology Development Co. Ltd.
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Vascular Dementia Assessment Scale-cognitive subscale(VADAS-Cog)
- Clinical Dementia Rating-Sum of Boxes (CDR-SB)
- Mini-Mental State Examination (MMSE)
- Activities of daily living (ADL)
|
160 |
All |
55 Years to 80 Years (Adult, Senior) |
NCT03230071 |
P2017-03-BDY-03-V03 |
|
August 1, 2017 |
December 30, 2019 |
June 30, 2020 |
July 26, 2017 |
July 28, 2017 |
|
- Dongzhimen Hospital ,Beijing University of Chinese Medicine
Beijing, Beijing, China
|
| 10 |
NCT03255967 |
Not yet recruiting |
Dementia Symptom Management at Home Program |
|
- Behavioral: DSM-H
- Behavioral: Standard of Care
|
Interventional |
Not Applicable |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Quality of Life-Alzheimer's Disease
- Change in Caregiver-Targeted Quality of Life Measure
|
300 |
All |
65 Years and older (Adult, Senior) |
NCT03255967 |
17-00810 |
|
March 2018 |
November 2018 |
November 2018 |
August 21, 2017 |
December 29, 2017 |
|
|
| 11 |
NCT03352791 |
Recruiting |
The Dementia Symptom Management at Home Program Hospice Edition |
|
- Behavioral: DSM-H Hospice Edition performance improvement program
- Behavioral: Usual Care
|
Interventional |
Not Applicable |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Supportive Care
|
- Reduction in pain (PAINAD)
- Reduction in Behavioral and Psychological Symptoms of Dementia (BPSD) using Neuropsychiatric Inventory Questionnaire (NPI-Q):
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT03352791 |
17-01080 |
|
January 1, 2018 |
January 2019 |
January 2020 |
November 24, 2017 |
March 30, 2018 |
|
- New York University School of Medicine
New York, New York, United States
|
| 12 |
NCT03121950 |
Recruiting |
Movement and Music Intervention for Individuals With Dementia |
- Dementia With Lewy Bodies
- Dementia
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in time to complete the Timed up and go cognitive
- Change in score on the Montreal Cognitive Assessment
|
30 |
All |
60 Years and older (Adult, Senior) |
NCT03121950 |
2016H0211 |
|
April 1, 2017 |
December 30, 2017 |
December 30, 2018 |
April 20, 2017 |
April 21, 2017 |
|
- Ohio State University
Columbus, Ohio, United States
|
| 13 |
NCT02426398 |
Recruiting |
Developing a New EEG Method for the Early Diagnosis of Dementia |
|
|
Observational |
|
- Sheffield Teaching Hospitals NHS Foundation Trust
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Significant spatiotemporal measurements from EEG
|
25 |
All |
18 Years and older (Adult, Senior) |
NCT02426398 |
STH18419 |
|
March 2015 |
December 31, 2020 |
December 31, 2020 |
April 24, 2015 |
March 29, 2018 |
|
- Sheffield Teaching Hospitals NHS Trust
Sheffield, S Yorks, United Kingdom
|
| 14 |
NCT03462485 |
Not yet recruiting |
Pilot Study of the Effects of Playing Golf on People With Dementia |
|
|
Interventional |
Not Applicable |
- University of Bedfordshire
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Quality of life
- Short Physical Performance Battery (SPPB)
- Assessment of Physical Activity in Frail Older People (APAFOP)
- (and 4 more...)
|
24 |
All |
40 Years and older (Adult, Senior) |
NCT03462485 |
IHREC820 |
|
April 30, 2018 |
August 31, 2018 |
October 31, 2018 |
March 12, 2018 |
March 27, 2018 |
|
- University of Bedfordshire
Luton, Bedfordshire, United Kingdom
|
| 15 |
NCT02908997 |
Recruiting |
MindMate: A Study of a Reminder System for People With Dementia |
|
|
Interventional |
Not Applicable |
- NHS Greater Glasgow and Clyde
- University of Glasgow
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
|
3 |
All |
18 Years and older (Adult, Senior) |
NCT02908997 |
GN16NE538 |
|
January 17, 2017 |
July 2018 |
July 2018 |
September 21, 2016 |
September 5, 2017 |
|
- NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
|
| 16 |
NCT02729311 |
Recruiting |
Paired Integrative Exercise Program for People With Dementia and Caregivers |
|
- Behavioral: Paired PLIÉ Program
|
Interventional |
Not Applicable |
- University of California, San Francisco
- Kaiser Permanente
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cognitive function (affected individual, direct assessment)
- Physical function (affected individual, direct assessment)
- Quality of life (affected individual, self-report)
- (and 11 more...)
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT02729311 |
NPSASA-15-364656 |
Paired PLIÉ |
July 1, 2016 |
December 31, 2018 |
December 31, 2018 |
April 6, 2016 |
October 31, 2017 |
|
- Kaiser Oakland
Oakland, California, United States
|
| 17 |
NCT02747745 |
Recruiting |
Theoretical Based Case Management Intervention for Dementia Family Caregivers |
|
- Behavioral: Four risk areas reflecting the great needs of FCGs of PWDs
|
Interventional |
Not Applicable |
- Chang Gung University
- Chang Gung Memorial Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Participant)
- Primary Purpose: Supportive Care
|
- The Change of FCG Quality of Life
- Yielding to FCG role (the PWD status)
|
152 |
All |
18 Years and older (Adult, Senior) |
NCT02747745 |
CMRPD1F0051 |
|
January 2016 |
December 2018 |
December 2018 |
April 22, 2016 |
April 22, 2016 |
|
- Catholic Mercy Hospital
Hukou, Hsinchu, Taiwan
|
| 18 |
NCT03378050 |
Not yet recruiting |
A Trial of a Multi-component Individualized Telephone-based Support Intervention for Adult-child Caregivers Caring for Parents With Dementia |
|
- Behavioral: HEART
- Other: Usual Care
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Caregiver Burden
- Health Related Quality of Life
- Reciprocal Filial Piety
- (and 2 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03378050 |
Yu12.17 |
|
January 2018 |
January 2020 |
September 2020 |
December 19, 2017 |
December 19, 2017 |
|
|
| 19 |
NCT02483520 |
Recruiting |
Supporting Family Caregivers With Technology for Dementia Home Care |
|
|
Interventional |
Not Applicable |
- University of Kansas Medical Center
- National Institute of Nursing Research (NINR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in behaviorally coded challenging behaviors (agitated, disruptive, resistive)
- Change in caregiver stress
- Change in caregiver burden
- (and 3 more...)
|
160 |
All |
18 Years and older (Adult, Senior) |
NCT02483520 |
STUDY00000053
R01NR014737 |
FamTechCare |
March 2014 |
January 31, 2019 |
January 31, 2019 |
June 29, 2015 |
April 3, 2018 |
|
- University of Iowa College of Nursing
Iowa City, Iowa, United States - University of Kansas Medical Center
Kansas City, Kansas, United States
|
| 20 |
NCT03413384 |
Not yet recruiting |
To Assess the Efficacy and Safety of Ceftriaxone in Patients With Mild to Moderate Parkinson's Disease Dementia |
- Parkinson's Disease Dementia
|
- Drug: Ceftriaxone
- Other: Placebo
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Compare the treatment difference in mean net change in Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) score with time course
- Changes in Unified Parkinson's Disease Rating Scale (UPDRS) score
- Changes in Judgment of Line Orientation score
- (and 6 more...)
|
106 |
All |
50 Years to 80 Years (Adult, Senior) |
NCT03413384 |
BRICEFA20170414 |
|
April 15, 2018 |
December 31, 2019 |
December 31, 2020 |
January 29, 2018 |
February 6, 2018 |
|
- Kaohsiung Medical University Hospital
Kaohsiung, Taiwan - Chung Shan Medical University Hospital
Taichung, Taiwan - Taichung Veterans General Hospital
Taichung, Taiwan - National Taiwan University Hospital
Taipei, Taiwan
|
| 21 |
NCT03402919 |
Recruiting |
Comprehensive Assessment of Neurodegeneration and Dementia |
|
|
Observational |
|
- McGill University
- Canadian Institutes of Health Research (CIHR)
- Alzheimer Society of Canada
- (and 14 more...)
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Montreal Cognitive Assessment (MoCA) score
|
2300 |
All |
50 Years to 90 Years (Adult, Senior) |
NCT03402919 |
CCNA 2015 |
COMPASS-ND |
June 2016 |
June 2021 |
June 2021 |
January 18, 2018 |
February 21, 2018 |
|
- Foothills Medical Centre
Calgary, Alberta, Canada - University of Alberta Hospital
Edmonton, Alberta, Canada - University of Northern British Columbia
Prince George, British Columbia, Canada - (and 27 more...)
|
| 22 |
NCT02727699 |
Recruiting |
A Phase II Study to Assess the Safety, Tolerability and Efficacy of Xanamem™ in Subjects With Mild Dementia Due to AD (XanADu) |
|
- Drug: Xanamem™
- Drug: Placebo (for Xanamem™)
|
Interventional |
Phase 2 |
- Actinogen Medical
- ICON Clinical Research
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- ADAS-Cog v14
- AD COMposite Scores
- RAVLT
- (and 4 more...)
|
174 |
All |
50 Years and older (Adult, Senior) |
NCT02727699 |
ACW0002 |
XanADu |
March 23, 2017 |
January 2019 |
March 2019 |
April 5, 2016 |
April 4, 2018 |
|
- National Research Institute
Los Angeles, California, United States - PCND Neuroscience Research Institute
Poway, California, United States - Northern California Research
Sacramento, California, United States - (and 19 more...)
|
| 23 |
NCT02983032 |
Not yet recruiting |
Brief Behavioural Treatment for Insomnia in Dementia Carers |
|
|
Interventional |
Not Applicable |
- NHS Greater Glasgow and Clyde
- University of Glasgow
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Sleep quality
- Sleep condition
- Anxiety
- (and 4 more...)
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT02983032 |
16/WS/0252 |
|
January 2017 |
September 2017 |
September 2017 |
December 6, 2016 |
December 12, 2016 |
|
- NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
|
| 24 |
NCT03305809 |
Recruiting |
A Study of LY3154207 in Participants With Parkinson's Disease Dementia |
- Parkinson's Disease Dementia
|
- Drug: LY3154207
- Drug: Placebo
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change from Baseline in the Continuity of Attention (CoA) Composite Score of the Cognitive Drug Research Computerized Cognition Battery (CDR-CCB)
- Change from Baseline on the Alzheimer's Disease Cooperative Study-Clinician Global Impression of Change (ADCS-CGIC) Score
- Change from Baseline on the CDR-CCB Power of Attention (PoA) Composite Score
- (and 12 more...)
|
340 |
All |
40 Years to 85 Years (Adult, Senior) |
NCT03305809 |
16261
I7S-MC-HBEH |
PRESENCE |
November 9, 2017 |
July 12, 2019 |
July 12, 2019 |
October 10, 2017 |
April 18, 2018 |
|
- University of Alabama Birmingham
Birmingham, Alabama, United States - Dignity Health Barrow Neurological Institute
Phoenix, Arizona, United States - Mayo Clinic of Scottsdale
Scottsdale, Arizona, United States - (and 87 more...)
|
| 25 |
NCT03445299 |
Not yet recruiting |
Music for Dementia-related Sleep Problems |
|
|
Interventional |
Not Applicable |
- University of Aarhus
- Danish Technical University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Sleep
- Sleep quality
- Depression
- (and 2 more...)
|
35 |
All |
60 Years and older (Adult, Senior) |
NCT03445299 |
D&S2017 |
|
February 23, 2018 |
December 1, 2018 |
December 1, 2018 |
February 26, 2018 |
February 26, 2018 |
|
- Center for Music in the Brain
Aarhus, Denmark
|
| 26 |
NCT03260920 |
Recruiting |
Intranasal Oxytocin for Frontotemporal Dementia |
|
|
Interventional |
Phase 2 |
- Lawson Health Research Institute
- Weston Foundation
- Canadian Institutes of Health Research (CIHR)
- Berry Consultants
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Neuropsychiatric Inventory (NPI) apathy/indifference domain score
- Change in emotional facial expression recognition performance
- Change in the Revised Self-Monitoring Scale score
- Change in modified Clinicians Global Impression of Change (apathy) scores
|
112 |
All |
30 Years to 80 Years (Adult, Senior) |
NCT03260920 |
FTDOXY17EF |
FOXY |
January 31, 2018 |
September 1, 2021 |
September 1, 2021 |
August 24, 2017 |
February 5, 2018 |
|
- UCLA
Los Angeles, California, United States - UCSF
San Francisco, California, United States - Johns Hopkins University
Baltimore, Maryland, United States - (and 8 more...)
|
| 27 |
NCT03116464 |
Recruiting |
Family Telemental Health Intervention for Veterans With Dementia |
- Dementia Family Caregiver Burden and Conflict
|
- Behavioral: Telemental Health Family Intervention
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Healthy Aging Brain Center Monitor (HABC Monitor):
- The Kansas Marital Conflict Scale (KMCS)
- Patient Health Questionnaire - 9 (PHQ)
- Zarit Burden Scale
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03116464 |
PPO 16-131
I21HX002256 |
|
September 18, 2017 |
April 16, 2018 |
April 15, 2019 |
April 17, 2017 |
February 26, 2018 |
|
- Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY
New York, New York, United States
|
| 28 |
NCT02914366 |
Recruiting |
Ambroxol as a Treatment for Parkinson's Disease Dementia |
- Parkinson's Disease Dementia
|
- Drug: Ambroxol
- Other: Placebo
|
Interventional |
Phase 2 |
- Lawson Health Research Institute
- Weston Foundation
- University of Western Ontario, Canada
- London Health Sciences Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog)
- Changes in the ADCS-Clinician's Global Impression of Change (CGIC)
- Changes in the Montreal Cognitive Assessment
- (and 13 more...)
|
75 |
All |
50 Years and older (Adult, Senior) |
NCT02914366 |
R15-006
105234
181033 |
|
November 2015 |
July 2018 |
December 2018 |
September 26, 2016 |
March 7, 2017 |
|
- Parkwood Institute
London, Ontario, Canada
|
| 29 |
NCT02804789 |
Recruiting |
European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS) |
|
|
Observational |
|
- University of Edinburgh
- Innovative Medicines Initiative
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in RBANS Composite score over time, units on a scale.
- Change in other Secondary Cognitive Tests score: Working Memory, over time, units on a scale.
- Change in other Secondary Cognitive Tests score: Choice Reaction Time and Set Shifting, over time, units on a scale.
- (and 3 more...)
|
6000 |
All |
50 Years and older (Adult, Senior) |
NCT02804789 |
EPAD-UoE-001 |
EPAD LCS |
May 2016 |
December 2019 |
December 2019 |
June 17, 2016 |
March 22, 2018 |
|
- CMRR du CHRU de Lille Hôpital Roger Salengro
Lille, France - CHU Gui de Chauliac Département de Neurologie
Montpellier, France - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal
Paris, France - (and 18 more...)
|
| 30 |
NCT01340001 |
Recruiting |
Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies |
- Dementia With Lewy Bodies
|
- Procedure: Electrical stimulation of the nucleus basalis of Meynert
|
Interventional |
Phase 1 |
- University Hospital, Rouen
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- free recalls of the FCSRT
- performances on different tests
|
6 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT01340001 |
2011/049/HP
2011-A00387-34 |
DEMENSTIM |
October 2012 |
October 2017 |
October 2017 |
April 21, 2011 |
December 7, 2016 |
|
- Maltête David
Rouen, France
|
| 31 |
NCT02845830 |
Not yet recruiting |
Trajectories of Quality of Life by the Elderly in Early Phase of Dementia |
|
|
Observational |
|
- Palacky University
- University Hospital Ostrava
- University Hospital Hradec Kralove
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Quality of Life - Alzheimer's Disease (QOL-AD)
- Geriatric Depression Scale by Yesavage (GDS-15)
- Mini Mental State Exam (MMSE)
- (and 2 more...)
|
580 |
All |
60 Years and older (Adult, Senior) |
NCT02845830 |
16-28628A |
|
September 2016 |
January 2020 |
July 2020 |
July 27, 2016 |
July 29, 2016 |
|
|
| 32 |
NCT03467152 |
Not yet recruiting |
Study To Evaluate the Efficacy, Safety and Tolerability of E2027 in Subjects With Dementia With Lewy Bodies |
- Dementia With Lewy Bodies
|
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mean change from baseline in the Montreal Cognitive Assessment (MoCA) total score at 12 weeks of treatment
- Mean Clinician's Interview Based Impression of Change Plus Caregiver Input (CIBIC-Plus) scale score at 12 weeks of treatment
- Mean change from baseline in the Neuropsychiatric Inventory (NPI) total score at 12 weeks of treatment
- (and 7 more...)
|
182 |
All |
50 Years to 85 Years (Adult, Senior) |
NCT03467152 |
E2027-G000-201
2017-003728-64 |
|
April 4, 2018 |
March 11, 2020 |
March 11, 2020 |
March 15, 2018 |
March 15, 2018 |
|
- MDFrist Research, LC
Chandler, Arizona, United States - Syrentis Clinical Research
Santa Ana, California, United States - Summit Research Network (Oregon) Inc.
Portland, Oregon, United States - (and 3 more...)
|
| 33 |
NCT01937013 |
Recruiting |
Impact of Emotional Mimicry and Oxytocin on Frontotemporal Dementia |
|
- Drug: Intranasal oxytocin
- Drug: Saline Nasal Mist
|
Interventional |
Phase 2 |
- Lawson Health Research Institute
- Canadian Institutes of Health Research (CIHR)
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Functional magnetic resonance imaging (fMRI) BOLD signal
- Cognitive and Emotional Task performance
|
72 |
All |
30 Years to 85 Years (Adult, Senior) |
NCT01937013 |
R-13-270
166786
103555
FTDOXY13EF |
IEMO |
September 2013 |
March 2018 |
March 2018 |
September 9, 2013 |
March 10, 2017 |
|
- Parkwood Hospital
London, Ontario, Canada
|
| 34 |
NCT03119259 |
Not yet recruiting |
iCare-AD: A Mobile Health Application for Caregivers of Patients With Dementia. |
|
- Behavioral: ABC Clinical Program
- Behavioral: HABC 2.0
|
Interventional |
Not Applicable |
- Richard Holden
- Indiana University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Behavioral and Psychological Symptoms of Dementia (BPSD) and Caregiver Distress
- Health Care Utilization
- Caregiver Depression
- (and 2 more...)
|
448 |
All |
18 Years and older (Adult, Senior) |
NCT03119259 |
1606267154 |
iCare-AD |
July 2018 |
January 1, 2023 |
July 1, 2023 |
April 18, 2017 |
August 16, 2017 |
|
- Eskenazi Health
Indianapolis, Indiana, United States - IU Health
Indianapolis, Indiana, United States
|
| 35 |
NCT03364179 |
Recruiting |
IssuEs in Palliative Care for People in Advanced and Terminal Stages of Young-onset and Late-Onset Dementia in GErmany |
- Advanced Dementia Stages
- Palliative Care
|
|
Observational |
|
- Technische Universität München
- Ludwig-Maximilians - University of Munich
- Deutsche Alzheimer Gesellschaft
- (and 2 more...)
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- patient´s quality of life in late stage dementia
- patient´s comfort of dying with dementia
- symptoms and symptom management in late-stage dementia and during the dying process
- (and 5 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT03364179 |
PALLVFKS022EPYLOGE |
EPYLOGE |
August 19, 2017 |
July 2019 |
December 2019 |
December 6, 2017 |
December 8, 2017 |
|
- Zentrum für kognitive Störungen, Psychiatrische Klinik und Poliklinik, Klinikum Rechts der Isar, TU München
München, Bayern, Germany
|
| 36 |
NCT03120741 |
Not yet recruiting |
Dementia Patient's Behavior Evaluation Using Noninvasive Ambient Sensor |
- Mild Cognitive Impairment, Dementia
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case-Control
- Time Perspective: Other
|
- The relationship between moving pattern change and dementia.
- The relationship between daily routine change and dementia.
- The relationship between sleeping time change and dementia.
|
35 |
All |
65 Years to 100 Years (Adult, Senior) |
NCT03120741 |
201608004RINB |
|
May 2017 |
August 2018 |
August 2018 |
April 19, 2017 |
April 19, 2017 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
| 37 |
NCT02621424 |
Recruiting |
Repetitive Transcranial Magnetic Stimulation for Dementia |
- Dementia
- Mild Cognitive Impairment
|
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- changes from baseline CVLT scores after treatment and 4 months later
- changes in Boston Naming after treatment and 4 months later
- changes in BDNF levels in serum and/or CSF after treatment and 4 months later
- (and 2 more...)
|
62 |
All |
55 Years to 99 Years (Adult, Senior) |
NCT02621424 |
E1889-P
RX14-009 |
rTMS for demen |
January 1, 2016 |
December 28, 2018 |
December 31, 2018 |
December 3, 2015 |
March 29, 2018 |
|
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
|
| 38 |
NCT02372773 |
Recruiting |
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects |
- Familial Frontotemporal Dementia
|
|
Observational |
|
- Mayo Clinic
- National Institute on Aging (NIA)
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
- Rate of decline in traditional measures of clinical (neuropsychological and behavioral composites) function and cortical volume on structural MRI in the symptomatic phase of familial FTD
- Rate of decline in traditional measures of clinical (neuropsychological and behavioral composites) function and cortical volume on structural MRI in the asymptomatic phase of familial FTD
- Value of novel imaging and clinical measures for characterizing asymptomatic familial FTD subjects, and factors predicting clinical rates of progression in each group.
- Genetic and biofluid factors that modify rates of clinical and neuroimaging decline in the asymptomatic and symptomatic phases of familial FTD.
|
300 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02372773 |
14-007532
U01AG045390 |
LEFFTDS |
April 2015 |
April 2019 |
April 2019 |
February 26, 2015 |
January 29, 2018 |
|
- University of California, San Francisco, Memory and Aging Center, Department of Neurology
San Francisco, California, United States - Mayo Clinic Florida
Jacksonville, Florida, United States - Harvard University
Charlestown, Massachusetts, United States - (and 5 more...)
|
| 39 |
NCT03328676 |
Recruiting |
The Effect of Cannabis on Dementia Related Agitation and Aggression |
- Agitation Related to Dementia
|
- Drug: Cannabis
- Drug: Placebo oil
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Proportion of subjects achieving a Cohen-Mansfield Agitation Inventory (CMAI) ≥ 4-point decrease during the treatment period.
|
60 |
All |
60 Years and older (Adult, Senior) |
NCT03328676 |
TO_D02_2016 |
|
December 7, 2017 |
November 2019 |
May 2020 |
November 1, 2017 |
February 23, 2018 |
|
- Laniado Hospital
Netanya, Israel
|
| 40 |
NCT02969499 |
Not yet recruiting |
Safety and Efficacy of ECT for BPSD |
|
|
Observational |
|
- University of British Columbia
- Ontario Shores Centre for Mental Health Sciences
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Change in Neuropsychiatric Inventory (NPI)
- Change in Pittsburgh Agitation Scale (PAS)
- Change in Cornell Depression Scale (CDS) before ECT, during treatment course and after treatment completion
- (and 4 more...)
|
30 |
All |
Child, Adult, Senior |
NCT02969499 |
H15-02351 |
ECTBPSD |
November 2016 |
December 2017 |
June 2018 |
November 21, 2016 |
November 21, 2016 |
|
- Vancouver General Hospital - Willow Pavilion
Vancouver, British Columbia, Canada - Ontario Shores
Whitby, Ontario, Canada
|
| 41 |
NCT02874300 |
Not yet recruiting |
Promoting Activity, Independence and Stability in Early Dementia |
- Dementia MCI (Mild Cognitive Impairment)
|
- Other: High intensity supervision arm
- Other: Moderate intensity supervision arm
|
Interventional |
Not Applicable |
- Nottingham University Hospitals NHS Trust
- National Institute for Health Research, United Kingdom
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Disability Assessment in Dementia (Gelinas and Gauthier, 1994)
- Falls (defined as 'unintentionally coming to rest on the ground or at a lower level, however caused')
|
60 |
All |
65 Years and older (Adult, Senior) |
NCT02874300 |
16HC001 |
PrAISED |
September 2016 |
March 2018 |
March 2019 |
August 22, 2016 |
August 23, 2016 |
|
|
| 42 |
NCT02937883 |
Recruiting |
Empowerment Intervention for Persons With Young Onset Dementia |
|
- Other: Empowerment intervention
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Changes in self-management abilities (Self-Management Ability Scale (SMAS))
- Changes in quality of life (Quality of life - Alzheimer Disease scale (QOL-AD))
- Changes in neuropsychiatric symptoms (Neuropsychiatric Inventory Questionnaire (NPI-Q))
- (and 4 more...)
|
100 |
All |
Child, Adult, Senior |
NCT02937883 |
733050607 |
|
September 2016 |
April 2018 |
April 2018 |
October 19, 2016 |
October 19, 2016 |
|
- Florence
Den Haag, Netherlands
|
| 43 |
NCT03303638 |
Recruiting |
Investigating the Impact of Multi-sensory Environments on Behavior During Assisted Bathing for Veterans With Dementia |
|
- Behavioral: Multi-sensory Environment
|
Interventional |
Not Applicable |
- University of Florida
- VA Office of Research and Development
|
Other / U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Behavior during assisted bathing
- Impact of MSE related to medication use
|
23 |
All |
18 Years and older (Adult, Senior) |
NCT03303638 |
IRB201700547 |
|
January 23, 2018 |
May 2018 |
December 2018 |
October 6, 2017 |
January 29, 2018 |
|
- Geriatric Research Education and Clinical Center
Gainesville, Florida, United States - Lake City VA Medical Center
Lake City, Florida, United States
|
| 44 |
NCT02864056 |
Recruiting |
The TACIT Trial: TAi ChI for People With demenTia |
|
|
Interventional |
Not Applicable |
- Bournemouth University
- Southern Health NHS Foundation Trust
- Dorset HealthCare University NHS Foundation Trust
- (and 6 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Timed Up and Go test
- Berg Balance Scale (BBS)
- Postural sway
- (and 8 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT02864056 |
TACIT001
CDF-2015-08-030
16/WS/0139 |
TACIT |
April 6, 2017 |
November 2018 |
November 2018 |
August 11, 2016 |
March 29, 2018 |
|
- Memory Assessment Service, Dorset HealthCare University Foundation Trust
Poole, Dorset, United Kingdom - Solent NHS Trust
Portsmouth, Hampshire, United Kingdom - Memory Assessment and Research Centre, Southern Health NHS Foundation Trust
Southampton, Hampshire, United Kingdom
|
| 45 |
NCT02919748 |
Recruiting |
Choral Singing For the Prevention of Dementia |
- Dementia
- Cognitive Decline
|
- Other: Choral Singing
- Other: Health Education Program
|
Interventional |
Not Applicable |
- National University, Singapore
- Agency for Science, Technology and Research
- Nanyang Technological University
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Changes in cognitive performance
- Changes in brain structure and function
- Changes in biological markers
- (and 14 more...)
|
360 |
All |
60 Years and older (Adult, Senior) |
NCT02919748 |
NUS-IRB: B-14-304 |
|
July 2015 |
December 2019 |
December 2019 |
September 29, 2016 |
April 2, 2018 |
|
- TaRA@JP
Singapore, Singapore
|
| 46 |
NCT03354819 |
Recruiting |
Effects of a Modified Mindfulness-based Cognitive Therapy for Family Caregivers of People With Dementia |
- Carer Stress Syndrome
- Dementia
|
- Behavioral: Modified MBCT
- Behavioral: SIRE on dementia
|
Interventional |
Not Applicable |
- The Hong Kong Polytechnic University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change of Perceived Stress Scale (PSS)
- Zarit Burden Scale (ZBI).
- Change of Center for Epidemiologic Studies Depression Scale (CESD)
- (and 3 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03354819 |
HSEARS20170929002 |
|
December 23, 2017 |
June 23, 2019 |
December 23, 2019 |
November 28, 2017 |
February 23, 2018 |
|
- Patrick Kor
Hong Kong, Hong Kong
|
| 47 |
NCT02945774 |
Recruiting |
Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias |
|
|
Interventional |
Not Applicable |
- Lawson Health Research Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Group differences in regional PET FEPPA ligand imaging
- Correlation between PET FEPPA ligand images and specified MR images
|
40 |
All |
30 Years to 95 Years (Adult, Senior) |
NCT02945774 |
107561 |
|
August 2016 |
February 2020 |
August 2021 |
October 26, 2016 |
February 5, 2018 |
|
- Parkwood Institute
London, Ontario, Canada
|
| 48 |
NCT02467413 |
Not yet recruiting |
BAC in Patient With Alzheimer's Disease or Vascular Dementia |
- Alzheimer's Disease
- Vascular Dementia
|
- Drug: BAC
- Other: BAC Matched Vehicle
|
Interventional |
Phase 2 |
- Charsire Biotechnology Corp.
- A2 Healthcare Taiwan Corporation
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Alzheimer's Disease Assessment Scale- Cognitive (ADAS-cog) score at Week-12 visit compared to baseline
- Change in ADAS-cog score at all post treatment visits (except Week-12 visit) compared to baseline
- Clinician's Interview Based Impression of Change-Plus Caregiver Input (CIBIC-plus) score at all post treatment visits
- (and 7 more...)
|
125 |
All |
40 Years and older (Adult, Senior) |
NCT02467413 |
BAC-01 |
|
December 1, 2017 |
December 2017 |
December 2017 |
June 10, 2015 |
July 21, 2017 |
|
- National Cheng Kung University Hospital
Tainan, Taiwan
|
| 49 |
NCT02672800 |
Recruiting |
A Psychosocial Intervention for Bereaved Spousal Caregivers of Persons With Dementia |
|
- Behavioral: the Reclaiming Yourself tool
|
Interventional |
Not Applicable |
- University of Saskatchewan
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Inventory of Daily Widowed Life (IDWL)- change at 1 and 2 months post-intervention
- Center for Epidemiologic Studies Depression Scale- Revised (CESD-R)- change at 1 and 2 months post-intervention
- Texas Revised Inventory of Grief, Present Feelings- change at 1 and 2 months post-intervention
- Semi-structured qualitative evaluation interviews
|
60 |
All |
60 Years and older (Adult, Senior) |
NCT02672800 |
15-313 |
|
March 2016 |
December 2017 |
September 2018 |
February 3, 2016 |
June 14, 2017 |
|
- University of Saskatchewan
Saskatoon, Saskatchewan, Canada
|
| 50 |
NCT03325556 |
Recruiting |
Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis |
- Dementia-related Psychosis
|
- Drug: Placebo
- Drug: Pimavanserin 34 mg
- Drug: Pimavanserin 20 mg
|
Interventional |
Phase 3 |
- ACADIA Pharmaceuticals Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time from randomization to relapse in the double-blind period
- Time from randomization to discontinuation from the double-blind period for any reason
|
356 |
All |
50 Years to 90 Years (Adult, Senior) |
NCT03325556 |
ACP-103-045
2017-002227-13 |
|
September 27, 2017 |
March 2020 |
March 2020 |
October 30, 2017 |
March 7, 2018 |
|
- ATP Clinical Research Inc.
Costa Mesa, California, United States - The Parkinson's and Movement Disorder Institute
Fountain Valley, California, United States - Neuro-Pain Medical Center
Fresno, California, United States - (and 44 more...)
|
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