| 1 |
NCT02925273 |
Recruiting |
Hand Grasping Techniques on Eliciting the Grasp Reflex in Patients With Dementia |
|
- Other: palmar grasp without dorsal stimulation
- Other: standard palmar grasp test with dorsal stimulation
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Grasp response
- Frontal Lobe release
- Frontal lobe release
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT02925273 |
GRASP |
GRASP |
July 2016 |
December 2016 |
June 2017 |
October 5, 2016 |
October 5, 2016 |
|
- Rowan University School of Osteopathic Medicine
Stratford, New Jersey, United States
|
|
| 2 |
NCT03260608 |
Recruiting |
Effectiveness of a Psychoeducation and Support Protocol by Phone in the Aid of Caregivers of Patients With Dementia. |
|
|
Interventional
|
Not Applicable |
- Hospital de Clinicas de Porto Alegre
- Federal University of Rio Grande do Sul
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change from baseline in the caregiver's level of burden
- Change from baseline in the caregivers's depressive symptoms
- Change from baseline in the caregivers's anxiety symptoms
- (and 3 more...)
|
148 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03260608 |
17-0326 |
|
August 8, 2017 |
September 2018 |
January 2019 |
August 24, 2017 |
November 8, 2017 |
|
- Hospital de Clínicas de Porto Alegre
Porto Alegre, Brazil
|
|
| 3 |
NCT03152630 |
Recruiting |
Research on the Early and Prognosis Diagnosis of Vascular Dementia |
|
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Composite cardiovascular outcome
- With at least 1 cardiovascular risk factor.
|
600 |
All |
65 Years and older (Older Adult) |
NCT03152630 |
201512101RINA |
|
March 30, 2016 |
January 2036 |
January 2036 |
May 15, 2017 |
May 15, 2017 |
|
|
|
| 4 |
NCT02388711 |
Recruiting |
A Trial of the C-TraC Intervention for Dementia Patients |
|
- Other: C-TraC Intervention
|
Interventional
|
Not Applicable |
- University of Wisconsin, Madison
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change from baseline in rehospitalizations at 14, 30 and 90-days
- Increase in patient delirium prevention/resolution
- Patient functional maintenance/recovery
- (and 2 more...)
|
1100 |
All |
65 Years and older (Older Adult) |
NCT02388711 |
2014-1221
2P50AG033514-06 |
|
March 2015 |
March 2019 |
March 2019 |
March 17, 2015 |
March 8, 2018 |
|
- University of Wisconsin Hospital
Madison, Wisconsin, United States
|
|
| 5 |
NCT03575026 |
Recruiting |
Effectiveness-Implementation Cluster RCT to Improve Community-dwelling Early Dementia Patients by Music Intervention |
|
- Behavioral: Music-with-movement
- Behavioral: Usual care
|
Interventional
|
Not Applicable |
- The Hong Kong Polytechnic University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in patients' anxiety
- Changes in patients' depression
- Changes in caregivers' stress and well-being
- (and 7 more...)
|
75 |
All |
60 Years and older (Adult, Older Adult) |
NCT03575026 |
5-ZH2P |
|
April 18, 2018 |
July 2019 |
December 2019 |
July 2, 2018 |
July 2, 2018 |
|
- School of Nursing, The Hong Kong Polytechnic University
Hong Kong, Hong Kong
|
|
| 6 |
NCT02814422 |
Recruiting |
Triglyceride-rich Lipoprotein and Development of Dementia |
|
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Composite cardiovascular outcome
- With at least 1 cardiovascular risk factor.
|
1000 |
All |
65 Years and older (Older Adult) |
NCT02814422 |
201407002RIND |
|
July 2014 |
July 2017 |
July 2017 |
June 27, 2016 |
January 18, 2017 |
|
|
|
| 7 |
NCT02482623 |
Recruiting |
The Dementia Symptom Management at Home Program |
|
- Behavioral: Dementia Symptom Management at Home Program
|
Interventional
|
Not Applicable |
- New York University
- Visiting Nurse Service of New York
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Supportive Care
|
- Person With Dementia Quality of Life
- Caregiver Quality of Life
- Person with Dementia Pain
- (and 5 more...)
|
150 |
All |
65 Years and older (Older Adult) |
NCT02482623 |
i14-01960 |
DSM-H |
August 1, 2017 |
March 1, 2018 |
May 31, 2018 |
June 26, 2015 |
September 13, 2017 |
|
- The New Jewish Home
New York, New York, United States - New York University College of Nursing
New York, New York, United States
|
|
| 8 |
NCT03620552 |
Recruiting
New |
18F-S16 PET/CT in Healthy Volunteers and Patients With Neurodegenerative Dementia |
- Neurodegenerative Dementia
|
|
Interventional
|
Early Phase 1 |
- Oriental Neurosurgery Evidence-Based-Study Team
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Semiquantitative assessment of lesions and biodistribution
- Blood pressure
- Pulse
- (and 6 more...)
|
30 |
All |
40 Years and older (Adult, Older Adult) |
NCT03620552 |
S16AD2018 |
|
August 20, 2017 |
October 20, 2018 |
February 20, 2019 |
August 8, 2018 |
August 8, 2018 |
|
- PET/CT center,Tianjin Medical University General Hospital
Tianjin, Tianjin, China
|
|
| 9 |
NCT03548142 |
Recruiting |
Advanced Dementia and End-of-life |
|
- Behavioral: provision of relevant information
|
Interventional
|
Not Applicable |
- Technische Universität München
- Bavarian State Ministry of Health and Care
- Deutsche Alzheimer Gesellschaft e.V. - German Alzheimer Association e.V.
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Patients' Perceived Involvement in Care Scale
- family caregivers´satisfaction with care
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03548142 |
palliative study |
|
July 11, 2017 |
September 2018 |
September 2018 |
June 7, 2018 |
June 7, 2018 |
|
- Center for Cognitive Disorders
Munich, Bavaria, Germany
|
|
| 10 |
NCT03255967 |
Recruiting |
Dementia Symptom Management at Home Program |
|
- Behavioral: DSM-H
- Behavioral: Standard of Care
|
Interventional
|
Not Applicable |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Quality of Life-Alzheimer's Disease
- Change in Caregiver-Targeted Quality of Life Measure
|
300 |
All |
65 Years and older (Older Adult) |
NCT03255967 |
17-00810 |
|
May 21, 2018 |
August 2021 |
August 2021 |
August 21, 2017 |
June 7, 2018 |
|
- New York University School of Medicine
New York, New York, United States
|
|
| 11 |
NCT03230071 |
Not yet recruiting |
Efficacy and Safety of TMBCZG in Mild to Moderate Vascular Dementia |
|
- Drug: TMBCZG
- Other: placebo
|
Interventional
|
Phase 2 |
- Dongzhimen Hospital, Beijing
- Beijing Union pharmaceutical factory II
- Beijing Compete Medical Technology Development Co. Ltd.
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Vascular Dementia Assessment Scale-cognitive subscale(VADAS-Cog)
- Clinical Dementia Rating-Sum of Boxes (CDR-SB)
- Mini-Mental State Examination (MMSE)
- Activities of daily living (ADL)
|
160 |
All |
55 Years to 80 Years (Adult, Older Adult) |
NCT03230071 |
P2017-03-BDY-03-V03 |
|
August 1, 2017 |
December 30, 2019 |
June 30, 2020 |
July 26, 2017 |
July 28, 2017 |
|
- Dongzhimen Hospital ,Beijing University of Chinese Medicine
Beijing, Beijing, China
|
|
| 12 |
NCT03577418 |
Not yet recruiting |
Enhancing Everyday Autonomy for People With Dementia |
|
- Behavioral: Clinician-facilitated educational intervention
- Behavioral: Enhanced usual care
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- NPI-Q
- NPI-Q, caregiver distress
|
30 |
All |
55 Years and older (Adult, Older Adult) |
NCT03577418 |
R03.JMW |
|
May 2019 |
May 2021 |
May 2021 |
July 4, 2018 |
July 11, 2018 |
|
|
|
| 13 |
NCT03352791 |
Recruiting |
The Dementia Symptom Management at Home Program Hospice Edition |
|
- Behavioral: DSM-H Hospice Edition performance improvement program
- Behavioral: Usual Care
|
Interventional
|
Not Applicable |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Supportive Care
|
- Reduction in pain (PAINAD)
- Reduction in Behavioral and Psychological Symptoms of Dementia (BPSD) using Neuropsychiatric Inventory Questionnaire (NPI-Q):
|
150 |
All |
18 Years and older (Adult, Older Adult) |
NCT03352791 |
17-01080 |
|
January 1, 2018 |
January 2019 |
January 2020 |
November 24, 2017 |
March 30, 2018 |
|
- New York University School of Medicine
New York, New York, United States
|
|
| 14 |
NCT03462485 |
Not yet recruiting |
Pilot Study of the Effects of Playing Golf on People With Dementia |
|
|
Interventional
|
Not Applicable |
- University of Bedfordshire
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Quality of life
- Short Physical Performance Battery (SPPB)
- Assessment of Physical Activity in Frail Older People (APAFOP)
- (and 4 more...)
|
24 |
All |
40 Years and older (Adult, Older Adult) |
NCT03462485 |
IHREC820 |
|
April 30, 2018 |
August 31, 2018 |
October 31, 2018 |
March 12, 2018 |
March 27, 2018 |
|
- University of Bedfordshire
Luton, Bedfordshire, United Kingdom
|
|
| 15 |
NCT02426398 |
Recruiting |
Developing a New EEG Method for the Early Diagnosis of Dementia |
|
|
Observational
|
|
- Sheffield Teaching Hospitals NHS Foundation Trust
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Significant spatiotemporal measurements from EEG
|
25 |
All |
18 Years and older (Adult, Older Adult) |
NCT02426398 |
STH18419 |
|
March 2015 |
December 31, 2020 |
December 31, 2020 |
April 24, 2015 |
March 29, 2018 |
|
- Sheffield Teaching Hospitals NHS Trust
Sheffield, S Yorks, United Kingdom
|
|
| 16 |
NCT03576170 |
Recruiting |
Investigate the Efficacy and Effectiveness of Aromatherapy for the Management of Behavioral and Psychological Symptoms of Dementia |
|
|
Interventional
|
Not Applicable |
- The Hong Kong Polytechnic University
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Chinese Version of the Cohen- Mansfield Agitation Inventory (CMAI)
- Chinese Version of the Neuropsychiatric Inventory (NPI)
- Cantonese Version of the Mini-mental State Examination (CMMSE)
- (and 2 more...)
|
120 |
All |
60 Years and older (Adult, Older Adult) |
NCT03576170 |
P17-0203-1 |
|
November 29, 2017 |
October 1, 2018 |
October 14, 2018 |
July 3, 2018 |
July 3, 2018 |
|
- The Hong Kong Polytechinic University
Hong Kong, Hong Kong
|
|
| 17 |
NCT03614962 |
Not yet recruiting
New |
Warmth and Transcutaneous Electrical Nerve Stimulation (TENS) in Improving Cognitive Functions in People With Dementia |
|
- Device: Warmth + TENS
- Device: Warmth + placebo-TENS
- Device: TENS
- (and 2 more...)
|
Interventional
|
Not Applicable |
- The Hong Kong Polytechnic University
- Prince of Wales Hospital, Shatin, Hong Kong
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) - Baseline
- The Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) - post intervention
- The Hong Kong version of Montreal Cognitive Assessment (HK-MoCA) - short term followup
- (and 9 more...)
|
150 |
All |
65 Years and older (Older Adult) |
NCT03614962 |
2018_ITF_MRP |
|
January 2, 2019 |
January 2, 2022 |
January 2, 2022 |
August 3, 2018 |
August 3, 2018 |
|
|
|
| 18 |
NCT03121950 |
Recruiting |
Movement and Music Intervention for Individuals With Dementia |
- Dementia With Lewy Bodies
- Dementia
|
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in time to complete the Timed up and go cognitive
- Change in score on the Montreal Cognitive Assessment
|
30 |
All |
60 Years and older (Adult, Older Adult) |
NCT03121950 |
2016H0211 |
|
April 1, 2017 |
December 30, 2017 |
December 30, 2018 |
April 20, 2017 |
April 21, 2017 |
|
- Ohio State University
Columbus, Ohio, United States
|
|
| 19 |
NCT02908997 |
Recruiting |
MindMate: A Study of a Reminder System for People With Dementia |
|
|
Interventional
|
Not Applicable |
- NHS Greater Glasgow and Clyde
- University of Glasgow
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
|
3 |
All |
18 Years and older (Adult, Older Adult) |
NCT02908997 |
GN16NE538 |
|
January 17, 2017 |
July 2018 |
July 2018 |
September 21, 2016 |
September 5, 2017 |
|
- NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
|
|
| 20 |
NCT02729311 |
Recruiting |
Paired Integrative Exercise Program for People With Dementia and Caregivers |
|
- Behavioral: Paired PLIÉ Program
|
Interventional
|
Not Applicable |
- University of California, San Francisco
- Kaiser Permanente
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cognitive function (affected individual, direct assessment)
- Physical function (affected individual, direct assessment)
- Quality of life (affected individual, self-report)
- (and 11 more...)
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT02729311 |
NPSASA-15-364656 |
Paired PLIÉ |
July 1, 2016 |
December 31, 2018 |
December 31, 2018 |
April 6, 2016 |
October 31, 2017 |
|
- Kaiser Oakland
Oakland, California, United States
|
|
| 21 |
NCT02747745 |
Recruiting |
Theoretical Based Case Management Intervention for Dementia Family Caregivers |
|
- Behavioral: Four risk areas reflecting the great needs of FCGs of PWDs
|
Interventional
|
Not Applicable |
- Chang Gung University
- Chang Gung Memorial Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Participant)
- Primary Purpose: Supportive Care
|
- The Change of FCG Quality of Life
- Yielding to FCG role (the PWD status)
|
152 |
All |
18 Years and older (Adult, Older Adult) |
NCT02747745 |
CMRPD1F0051 |
|
January 2016 |
December 2018 |
December 2018 |
April 22, 2016 |
April 22, 2016 |
|
- Catholic Mercy Hospital
Hukou, Hsinchu, Taiwan
|
|
| 22 |
NCT03378050 |
Not yet recruiting |
A Trial of a Multi-component Individualized Telephone-based Support Intervention for Adult-child Caregivers Caring for Parents With Dementia |
|
- Behavioral: HEART
- Other: Usual Care
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Caregiver Burden
- Health Related Quality of Life
- Reciprocal Filial Piety
- (and 2 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03378050 |
Yu12.17 |
|
January 2018 |
January 2020 |
September 2020 |
December 19, 2017 |
December 19, 2017 |
|
|
|
| 23 |
NCT02483520 |
Recruiting |
Supporting Family Caregivers With Technology for Dementia Home Care |
|
|
Interventional
|
Not Applicable |
- University of Kansas Medical Center
- National Institute of Nursing Research (NINR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in behaviorally coded challenging behaviors (agitated, disruptive, resistive)
- Change in caregiver stress
- Change in caregiver burden
- (and 3 more...)
|
160 |
All |
18 Years and older (Adult, Older Adult) |
NCT02483520 |
STUDY00000053
R01NR014737 |
FamTechCare |
March 2014 |
January 31, 2019 |
January 31, 2019 |
June 29, 2015 |
April 3, 2018 |
|
- University of Iowa College of Nursing
Iowa City, Iowa, United States - University of Kansas Medical Center
Kansas City, Kansas, United States
|
|
| 24 |
NCT03413384 |
Not yet recruiting |
To Assess the Efficacy and Safety of Ceftriaxone in Patients With Mild to Moderate Parkinson's Disease Dementia |
- Parkinson's Disease Dementia
|
- Drug: Ceftriaxone
- Other: Placebo
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Compare the treatment difference in mean net change in Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) score with time course
- Changes in Unified Parkinson's Disease Rating Scale (UPDRS) score
- Changes in Judgment of Line Orientation score
- (and 6 more...)
|
106 |
All |
50 Years to 80 Years (Adult, Older Adult) |
NCT03413384 |
BRICEFA20170414 |
|
September 15, 2018 |
December 31, 2019 |
December 31, 2020 |
January 29, 2018 |
July 11, 2018 |
|
- Kaohsiung Medical University Hospital
Kaohsiung, Taiwan - Chung Shan Medical University Hospital
Taichung, Taiwan - Taichung Veterans General Hospital
Taichung, Taiwan - National Taiwan University Hospital
Taipei, Taiwan
|
|
| 25 |
NCT03402919 |
Recruiting |
Comprehensive Assessment of Neurodegeneration and Dementia |
|
|
Observational
|
|
- McGill University
- Canadian Institutes of Health Research (CIHR)
- Alzheimer Society of Canada
- (and 14 more...)
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Montreal Cognitive Assessment (MoCA) score
|
2300 |
All |
50 Years to 90 Years (Adult, Older Adult) |
NCT03402919 |
CCNA 2015 |
COMPASS-ND |
June 2016 |
June 2021 |
June 2021 |
January 18, 2018 |
February 21, 2018 |
|
- Foothills Medical Centre
Calgary, Alberta, Canada - University of Alberta Hospital
Edmonton, Alberta, Canada - University of Northern British Columbia
Prince George, British Columbia, Canada - (and 27 more...)
|
|
| 26 |
NCT02983032 |
Not yet recruiting |
Brief Behavioural Treatment for Insomnia in Dementia Carers |
|
|
Interventional
|
Not Applicable |
- NHS Greater Glasgow and Clyde
- University of Glasgow
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Sleep quality
- Sleep condition
- Anxiety
- (and 4 more...)
|
15 |
All |
18 Years and older (Adult, Older Adult) |
NCT02983032 |
16/WS/0252 |
|
January 2017 |
September 2017 |
September 2017 |
December 6, 2016 |
December 12, 2016 |
|
- NHS Greater Glasgow and Clyde
Glasgow, United Kingdom
|
|
| 27 |
NCT02727699 |
Recruiting |
A Phase II Study to Assess the Safety, Tolerability and Efficacy of Xanamem™ in Subjects With Mild Dementia Due to AD (XanADu) |
|
- Drug: Xanamem™
- Drug: Placebo (for Xanamem™)
|
Interventional
|
Phase 2 |
- Actinogen Medical
- ICON Clinical Research
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- ADAS-Cog v14
- AD COMposite Scores
- RAVLT
- (and 4 more...)
|
174 |
All |
50 Years and older (Adult, Older Adult) |
NCT02727699 |
ACW0002 |
XanADu |
March 23, 2017 |
January 2019 |
March 2019 |
April 5, 2016 |
June 25, 2018 |
|
- Tucson Neuroscience Research, LLC
Tucson, Arizona, United States - National Research Institute
Los Angeles, California, United States - PCND Neuroscience Research Institute
Poway, California, United States - (and 24 more...)
|
|
| 28 |
NCT03305809 |
Recruiting |
A Study of LY3154207 in Participants With Parkinson's Disease Dementia |
- Parkinson's Disease Dementia
|
- Drug: LY3154207
- Drug: Placebo
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change from Baseline in the Continuity of Attention (CoA) Composite Score of the Cognitive Drug Research Computerized Cognition Battery (CDR-CCB)
- Change from Baseline on the Alzheimer's Disease Cooperative Study-Clinician Global Impression of Change (ADCS-CGIC) Score
- Change from Baseline on the CDR-CCB Power of Attention (PoA) Composite Score
- (and 12 more...)
|
340 |
All |
40 Years to 85 Years (Adult, Older Adult) |
NCT03305809 |
16261
I7S-MC-HBEH |
PRESENCE |
November 9, 2017 |
July 12, 2019 |
July 12, 2019 |
October 10, 2017 |
August 13, 2018 |
|
- University of Alabama Birmingham
Birmingham, Alabama, United States - Dignity Health Barrow Neurological Institute
Phoenix, Arizona, United States - Mayo Clinic of Scottsdale
Scottsdale, Arizona, United States - (and 86 more...)
|
|
| 29 |
NCT03584568 |
Not yet recruiting |
Reappraising Intergeneration Relationships in Dementia Caregiving |
|
- Behavioral: Perspective Taking Reappraisal
- Other: Basic Skill Building
|
Interventional
|
Not Applicable |
- The Hong Kong Polytechnic University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Center for Epidemiological Studies-Depression Search Results Center for Epidemiological Studies Depression
- Change in Ryff's Psychological Well-being
- Change in Revised Memory and Problem Checklist
- Change in MacArther Social Support Scales
|
154 |
All |
20 Years to 60 Years (Adult) |
NCT03584568 |
GRFPTR2018 |
|
August 12, 2018 |
July 8, 2021 |
July 8, 2021 |
July 12, 2018 |
July 12, 2018 |
|
|
|
| 30 |
NCT03597360 |
Not yet recruiting
New |
Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia: A Pilot Study |
|
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Alzheimer Disease Functional Assessment and Change Scale (ADFACS)
- Severe Impairment Battery (SIB)
- Cohen-Mansfield Agitation Index (CMAI)
|
3 |
All |
70 Years to 90 Years (Older Adult) |
NCT03597360 |
Baycrest REB # 18-02 |
LDIR-CT-AD |
August 2018 |
April 2019 |
June 2019 |
July 24, 2018 |
July 24, 2018 |
|
- Baycrest Health Sciences
Toronto, Ontario, Canada
|
|
| 31 |
NCT03260920 |
Recruiting |
Intranasal Oxytocin for Frontotemporal Dementia |
|
|
Interventional
|
Phase 2 |
- Lawson Health Research Institute
- The Weston A. Price Foundation
- Canadian Institutes of Health Research (CIHR)
- Berry Consultants
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Neuropsychiatric Inventory (NPI) apathy/indifference domain score
- Change in emotional facial expression recognition performance
- Change in the Revised Self-Monitoring Scale score
- Change in modified Clinicians Global Impression of Change (apathy) scores
|
112 |
All |
30 Years to 80 Years (Adult, Older Adult) |
NCT03260920 |
FTDOXY17EF |
FOXY |
January 31, 2018 |
September 1, 2021 |
September 1, 2021 |
August 24, 2017 |
June 28, 2018 |
|
- UCLA
Los Angeles, California, United States - UCSF
San Francisco, California, United States - Johns Hopkins University
Baltimore, Maryland, United States - (and 8 more...)
|
|
| 32 |
NCT03116464 |
Recruiting |
Family Telemental Health Intervention for Veterans With Dementia |
- Dementia Family Caregiver Burden and Conflict
|
- Behavioral: Telemental Health Family Intervention
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Healthy Aging Brain Center Monitor (HABC Monitor):
- The Kansas Marital Conflict Scale (KMCS)
- Patient Health Questionnaire - 9 (PHQ)
- Zarit Burden Scale
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT03116464 |
PPO 16-131
I21HX002256 |
|
September 18, 2017 |
April 16, 2019 |
April 15, 2020 |
April 17, 2017 |
April 23, 2018 |
|
- Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY
New York, New York, United States
|
|
| 33 |
NCT03445299 |
Recruiting |
Music for Dementia-related Sleep Problems |
|
|
Interventional
|
Not Applicable |
- University of Aarhus
- Danish Technical University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Sleep
- Sleep quality
- Depression
- (and 2 more...)
|
35 |
All |
60 Years and older (Adult, Older Adult) |
NCT03445299 |
D&S2017 |
|
February 26, 2018 |
December 1, 2018 |
December 1, 2018 |
February 26, 2018 |
May 7, 2018 |
|
- Center for Music in the Brain
Aarhus, Denmark
|
|
| 34 |
NCT02914366 |
Recruiting |
Ambroxol as a Treatment for Parkinson's Disease Dementia |
- Parkinson's Disease Dementia
|
- Drug: Ambroxol
- Other: Placebo
|
Interventional
|
Phase 2 |
- Lawson Health Research Institute
- The Weston A. Price Foundation
- University of Western Ontario, Canada
- London Health Sciences Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog)
- Changes in the ADCS-Clinician's Global Impression of Change (CGIC)
- Changes in the Montreal Cognitive Assessment
- (and 13 more...)
|
75 |
All |
50 Years and older (Adult, Older Adult) |
NCT02914366 |
R15-006
105234
181033 |
|
November 2015 |
July 2018 |
December 2018 |
September 26, 2016 |
March 7, 2017 |
|
- Parkwood Institute
London, Ontario, Canada
|
|
| 35 |
NCT02804789 |
Recruiting |
European Prevention of Alzheimer's Dementia (EPAD) Longitudinal Cohort Study (LCS) |
|
|
Observational
|
|
- University of Edinburgh
- Innovative Medicines Initiative
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in RBANS Composite score over time, units on a scale.
- Change in other Secondary Cognitive Tests score: Working Memory, over time, units on a scale.
- Change in other Secondary Cognitive Tests score: Choice Reaction Time and Set Shifting, over time, units on a scale.
- (and 3 more...)
|
6000 |
All |
50 Years and older (Adult, Older Adult) |
NCT02804789 |
EPAD-UoE-001 |
EPAD LCS |
May 2016 |
December 2019 |
December 2019 |
June 17, 2016 |
March 22, 2018 |
|
- CMRR du CHRU de Lille Hôpital Roger Salengro
Lille, France - CHU Gui de Chauliac Département de Neurologie
Montpellier, France - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal
Paris, France - (and 18 more...)
|
|
| 36 |
NCT03592862 |
Recruiting
New |
A Study to Assess Safety, Tolerability, and Efficacy of HTL0018318 in Patients With Dementia With Lewy Bodies |
- Dementia With Lewy Bodies
|
- Drug: HTL0018318
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Heptares Therapeutics Limited
- Sosei
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Incidence and severity of treatment related adverse events
- Change in systolic, diastolic blood pressure and heart rate
- Change from baseline in measures of cognitive impairment
- Change from baseline in measures of psychosis (i.e. hallucinations and delusions)
|
172 |
All |
50 Years to 85 Years (Adult, Older Adult) |
NCT03592862 |
HTL0018318-203 |
DLB |
August 2018 |
July 2020 |
January 2021 |
July 19, 2018 |
August 15, 2018 |
|
- Nishitaga Hospital
Sendai, Japan - Kagawa Prefectural Central Hospital
Takamatsu, Japan - Kurumi Clinic
Tokyo, Japan
|
|
| 37 |
NCT03467152 |
Recruiting |
Study To Evaluate the Efficacy, Safety and Tolerability of E2027 in Participants With Dementia With Lewy Bodies |
- Dementia With Lewy Bodies
|
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mean Change from Baseline in the Montreal Cognitive Assessment (MoCA) Total Score at 12 Weeks of Treatment
- Mean Clinician's Interview Based Impression of Change Plus Caregiver Input (CIBIC-Plus) Scale Score at 12 Weeks of Treatment
- Mean Change from Baseline in the Neuropsychiatric Inventory (NPI) Total Score at 12 Weeks of Treatment
- (and 7 more...)
|
182 |
All |
50 Years to 85 Years (Adult, Older Adult) |
NCT03467152 |
E2027-G000-201
2017-003728-64 |
|
May 4, 2018 |
March 11, 2020 |
March 11, 2020 |
March 15, 2018 |
July 16, 2018 |
|
- Brain and Spine Center
Chandler, Arizona, United States - Parkinsons and Movement Disorders Institute
Fountain Valley, California, United States - Syrentis Clinical Research
Santa Ana, California, United States - (and 19 more...)
|
|
| 38 |
NCT02845830 |
Not yet recruiting |
Trajectories of Quality of Life by the Elderly in Early Phase of Dementia |
|
|
Observational
|
|
- Palacky University
- University Hospital Ostrava
- University Hospital Hradec Kralove
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Quality of Life - Alzheimer's Disease (QOL-AD)
- Geriatric Depression Scale by Yesavage (GDS-15)
- Mini Mental State Exam (MMSE)
- (and 2 more...)
|
580 |
All |
60 Years and older (Adult, Older Adult) |
NCT02845830 |
16-28628A |
|
September 2016 |
January 2020 |
July 2020 |
July 27, 2016 |
July 29, 2016 |
|
|
|
| 39 |
NCT03119259 |
Not yet recruiting |
iCare-AD: A Mobile Health Application for Caregivers of Patients With Dementia. |
|
- Behavioral: ABC Clinical Program
- Behavioral: HABC 2.0
|
Interventional
|
Not Applicable |
- Richard Holden
- Indiana University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Behavioral and Psychological Symptoms of Dementia (BPSD) and Caregiver Distress
- Health Care Utilization
- Caregiver Depression
- (and 2 more...)
|
448 |
All |
18 Years and older (Adult, Older Adult) |
NCT03119259 |
1606267154 |
iCare-AD |
July 2018 |
January 1, 2023 |
July 1, 2023 |
April 18, 2017 |
August 16, 2017 |
|
- Eskenazi Health
Indianapolis, Indiana, United States - IU Health
Indianapolis, Indiana, United States
|
|
| 40 |
NCT03120741 |
Not yet recruiting |
Dementia Patient's Behavior Evaluation Using Noninvasive Ambient Sensor |
- Mild Cognitive Impairment, Dementia
|
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case-Control
- Time Perspective: Other
|
- The relationship between moving pattern change and dementia.
- The relationship between daily routine change and dementia.
- The relationship between sleeping time change and dementia.
|
35 |
All |
65 Years to 100 Years (Older Adult) |
NCT03120741 |
201608004RINB |
|
May 2017 |
August 2018 |
August 2018 |
April 19, 2017 |
April 19, 2017 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
|
| 41 |
NCT03364179 |
Recruiting |
IssuEs in Palliative Care for People in Advanced and Terminal Stages of Young-onset and Late-Onset Dementia in GErmany |
- Advanced Dementia Stages
- Palliative Care
|
|
Observational
|
|
- Technische Universität München
- Ludwig-Maximilians - University of Munich
- Deutsche Alzheimer Gesellschaft
- (and 2 more...)
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- patient´s quality of life in late stage dementia
- patient´s comfort of dying with dementia
- symptoms and symptom management in late-stage dementia and during the dying process
- (and 5 more...)
|
300 |
All |
18 Years and older (Adult, Older Adult) |
NCT03364179 |
PALLVFKS022EPYLOGE |
EPYLOGE |
August 19, 2017 |
July 2019 |
December 2019 |
December 6, 2017 |
December 8, 2017 |
|
- Zentrum für kognitive Störungen, Psychiatrische Klinik und Poliklinik, Klinikum Rechts der Isar, TU München
München, Bayern, Germany
|
|
| 42 |
NCT02969499 |
Recruiting |
Safety and Efficacy of ECT for BPSD |
|
|
Observational
|
|
- University of British Columbia
- Ontario Shores Centre for Mental Health Sciences
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Change in Neuropsychiatric Inventory (NPI)
- Change in Pittsburgh Agitation Scale (PAS)
- Change in Cornell Depression Scale (CDS) before ECT, during treatment course and after treatment completion
- (and 4 more...)
|
30 |
All |
Child, Adult, Older Adult |
NCT02969499 |
H15-02351 |
ECTBPSD |
November 2016 |
June 2019 |
December 2019 |
November 21, 2016 |
May 21, 2018 |
|
- Mount Saint Joseph's Hospital
Vancouver, British Columbia, Canada - Vancouver General Hospital - Willow Pavilion
Vancouver, British Columbia, Canada - Ontario Shores
Whitby, Ontario, Canada
|
|
| 43 |
NCT03328676 |
Recruiting |
The Effect of Cannabis on Dementia Related Agitation and Aggression |
- Agitation Related to Dementia
|
- Drug: Cannabis
- Drug: Placebo oil
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Proportion of subjects achieving a Cohen-Mansfield Agitation Inventory (CMAI) ≥ 4-point decrease during the treatment period.
|
60 |
All |
60 Years and older (Adult, Older Adult) |
NCT03328676 |
TO_D02_2016 |
|
December 7, 2017 |
November 2019 |
May 2020 |
November 1, 2017 |
February 23, 2018 |
|
- Laniado Hospital
Netanya, Israel
|
|
| 44 |
NCT02372773 |
Recruiting |
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects |
- Familial Frontotemporal Dementia
|
|
Observational
|
|
- Mayo Clinic
- National Institute on Aging (NIA)
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
- Rate of decline in traditional measures of clinical (neuropsychological and behavioral composites) function and cortical volume on structural MRI in the symptomatic phase of familial FTD
- Rate of decline in traditional measures of clinical (neuropsychological and behavioral composites) function and cortical volume on structural MRI in the asymptomatic phase of familial FTD
- Value of novel imaging and clinical measures for characterizing asymptomatic familial FTD subjects, and factors predicting clinical rates of progression in each group.
- Genetic and biofluid factors that modify rates of clinical and neuroimaging decline in the asymptomatic and symptomatic phases of familial FTD.
|
300 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02372773 |
14-007532
U01AG045390 |
LEFFTDS |
April 2015 |
April 2019 |
April 2019 |
February 26, 2015 |
January 29, 2018 |
|
- University of California, San Francisco, Memory and Aging Center, Department of Neurology
San Francisco, California, United States - Mayo Clinic Florida
Jacksonville, Florida, United States - Harvard University
Charlestown, Massachusetts, United States - (and 5 more...)
|
|
| 45 |
NCT02621424 |
Recruiting |
Repetitive Transcranial Magnetic Stimulation for Dementia |
- Dementia
- Mild Cognitive Impairment
|
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- changes from baseline CVLT scores after treatment and 4 months later
- changes in Boston Naming after treatment and 4 months later
- changes in BDNF levels in serum and/or CSF after treatment and 4 months later
- (and 2 more...)
|
62 |
All |
55 Years to 99 Years (Adult, Older Adult) |
NCT02621424 |
E1889-P
RX14-009 |
rTMS for demen |
January 1, 2016 |
December 28, 2018 |
December 31, 2018 |
December 3, 2015 |
March 29, 2018 |
|
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
|
|
| 46 |
NCT02874300 |
Not yet recruiting |
Promoting Activity, Independence and Stability in Early Dementia |
- Dementia MCI (Mild Cognitive Impairment)
|
- Other: High intensity supervision arm
- Other: Moderate intensity supervision arm
|
Interventional
|
Not Applicable |
- Nottingham University Hospitals NHS Trust
- National Institute for Health Research, United Kingdom
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Disability Assessment in Dementia (Gelinas and Gauthier, 1994)
- Falls (defined as 'unintentionally coming to rest on the ground or at a lower level, however caused')
|
60 |
All |
65 Years and older (Older Adult) |
NCT02874300 |
16HC001 |
PrAISED |
September 2016 |
March 2018 |
March 2019 |
August 22, 2016 |
August 23, 2016 |
|
|
|
| 47 |
NCT03608553 |
Recruiting
New |
A Study to Evaluate the Safety and Feasibility of Temporary Blood Brain Barrier Disruption Using MR Guided FUS in Patients With Parkinson's Disease Dementia |
- Parkinsons Disease With Dementia
|
- Device: MR Guided Focused Ultrasound
|
Interventional
|
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with treatment related Adverse Events as assessed by patient examination and MR imaging
|
10 |
All |
60 Years to 75 Years (Adult, Older Adult) |
NCT03608553 |
PD008 |
|
October 7, 2018 |
December 31, 2019 |
December 31, 2020 |
August 1, 2018 |
August 1, 2018 |
|
- HM Hospitales Puerta del Sur - CINAC
Móstoles, Madrid, Spain
|
|
| 48 |
NCT03303638 |
Recruiting |
Investigating the Impact of Multi-sensory Environments on Behavior During Assisted Bathing for Veterans With Dementia |
|
- Behavioral: Multi-sensory Environment
|
Interventional
|
Not Applicable |
- University of Florida
- US Department of Veterans Affairs
|
Other / U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Behavior during assisted bathing
- Impact of MSE related to medication use
|
23 |
All |
18 Years and older (Adult, Older Adult) |
NCT03303638 |
IRB201700547 |
|
January 23, 2018 |
August 2019 |
October 2019 |
October 6, 2017 |
August 17, 2018 |
|
- Geriatric Research Education and Clinical Center
Gainesville, Florida, United States - Lake City VA Medical Center
Lake City, Florida, United States
|
|
| 49 |
NCT02945774 |
Recruiting |
Molecular Neuroimaging of Neuroinflammation in Neurodegenerative Dementias |
|
|
Interventional
|
Not Applicable |
- Lawson Health Research Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Group differences in regional PET FEPPA ligand imaging
- Correlation between PET FEPPA ligand images and specified MR images
|
40 |
All |
30 Years to 95 Years (Adult, Older Adult) |
NCT02945774 |
107561 |
|
August 2016 |
February 2020 |
August 2021 |
October 26, 2016 |
February 5, 2018 |
|
- Parkwood Institute
London, Ontario, Canada
|
|
| 50 |
NCT03325556 |
Recruiting |
Relapse Prevention Study of Pimavanserin in Dementia-related Psychosis |
- Dementia-related Psychosis
|
- Drug: Placebo
- Drug: Pimavanserin 34 mg
- Drug: Pimavanserin 20 mg
|
Interventional
|
Phase 3 |
- ACADIA Pharmaceuticals Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time from randomization to relapse in the double-blind period
- Time from randomization to discontinuation from the double-blind period for any reason
|
356 |
All |
50 Years to 90 Years (Adult, Older Adult) |
NCT03325556 |
ACP-103-045
2017-002227-13 |
|
September 27, 2017 |
March 2020 |
March 2020 |
October 30, 2017 |
July 26, 2018 |
|
- ATP Clinical Research Inc.
Costa Mesa, California, United States - The Parkinson's and Movement Disorder Institute
Fountain Valley, California, United States - Neuro-Pain Medical Center
Fresno, California, United States - (and 90 more...)
|
|
| 51 |
NCT02919748 |
Recruiting |
Choral Singing For the Prevention of Dementia |
- Dementia
- Cognitive Decline
|
- Other: Choral Singing
- Other: Health Education Program
|
Interventional
|
Not Applicable |
- National University, Singapore
- Agency for Science, Technology and Research
- Nanyang Technological University
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Changes in cognitive performance
- Changes in brain structure and function
- Changes in biological markers
- (and 14 more...)
|
360 |
All |
60 Years and older (Adult, Older Adult) |
NCT02919748 |
NUS-IRB: B-14-304 |
|
July 2015 |
December 2019 |
December 2019 |
September 29, 2016 |
April 2, 2018 |
|
- TaRA@JP
Singapore, Singapore
|
|
| 52 |
NCT03593070 |
Not yet recruiting
New |
Dementia Caregiver Chronic Grief Management: A Live Online Video Intervention |
- Chronic Grief
- Dementia Family Caregivers
|
- Behavioral: Chronic Grief Management Intervention-Video
|
Interventional
|
Not Applicable |
- Rush University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Caregiver Chronic Grief
- Change in Depressive symptoms
- Change in Anxiety symptoms
- (and 3 more...)
|
144 |
All |
21 Years and older (Adult, Older Adult) |
NCT03593070 |
1R01AG056393-01A1 |
CGMI-V |
August 2018 |
July 2021 |
July 2021 |
July 19, 2018 |
July 19, 2018 |
|
|
|
| 53 |
NCT03354819 |
Recruiting |
Effects of a Modified Mindfulness-based Cognitive Therapy for Family Caregivers of People With Dementia |
- Carer Stress Syndrome
- Dementia
|
- Behavioral: Modified MBCT
- Behavioral: SIRE on dementia
|
Interventional
|
Not Applicable |
- The Hong Kong Polytechnic University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change of Perceived Stress Scale (PSS)
- Zarit Burden Scale (ZBI).
- Change of Center for Epidemiologic Studies Depression Scale (CESD)
- (and 3 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03354819 |
HSEARS20170929002 |
|
December 23, 2017 |
June 23, 2019 |
December 23, 2019 |
November 28, 2017 |
February 23, 2018 |
|
- Patrick Kor
Hong Kong, Hong Kong
|
|
| 54 |
NCT03451760 |
Not yet recruiting |
Feru-guard for Behavioral Symptoms in Dementia |
- Behavioral and Psychiatric Symptoms of Dementia
|
- Drug: Feru-guard 100M
- Other: Feru-guard 100M Placebo
|
Interventional
|
Phase 2 |
- Glovia Co., Ltd.
- Oregon Health and Science University
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline Neuropsychiatric Inventory Questionnaire at 12 weeks
- Change from Baseline Neuropsychiatric Inventory Questionnaire subscale of caregiver distress at 12 weeks
- Change from Baseline Zarit Burden Interview Screening Version at 12 weeks
- Change from Baseline Short Form Health Survey 12-Item at 12 weeks
|
70 |
All |
55 Years and older (Adult, Older Adult) |
NCT03451760 |
17966 |
|
September 2018 |
December 2019 |
December 2019 |
March 2, 2018 |
August 3, 2018 |
|
|
|
| 55 |
NCT02467413 |
Not yet recruiting |
BAC in Patient With Alzheimer's Disease or Vascular Dementia |
- Alzheimer's Disease
- Vascular Dementia
|
- Drug: BAC
- Other: BAC Matched Vehicle
|
Interventional
|
Phase 2 |
- Charsire Biotechnology Corp.
- A2 Healthcare Taiwan Corporation
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Alzheimer's Disease Assessment Scale- Cognitive (ADAS-cog) score at Week-12 visit compared to baseline
- Change in ADAS-cog score at all post treatment visits (except Week-12 visit) compared to baseline
- Clinician's Interview Based Impression of Change-Plus Caregiver Input (CIBIC-plus) score at all post treatment visits
- (and 7 more...)
|
125 |
All |
40 Years and older (Adult, Older Adult) |
NCT02467413 |
BAC-01 |
|
December 1, 2019 |
June 2021 |
December 2021 |
June 10, 2015 |
July 18, 2018 |
|
- National Cheng Kung University Hospital
Tainan, Taiwan
|
|
| 56 |
NCT03481933 |
Not yet recruiting |
Evaluation of a Transcranial Stimulation With Direct Current on Language Disorders in Semantic Dementia |
|
- Device: Transcranial stimulation
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Significant improvement of semantic performances on the experimental 'semantic matching test'
- Significant modulation of semantic performances on the 'semantic matching test'
- significant modulation of cortical metabolism and functional connectivity
- Detection of a potential outcome difference between left-excitatory and right-inhibitory tDCS
|
80 |
All |
18 Years and older (Adult, Older Adult) |
NCT03481933 |
P160937J |
STIM-SD |
March 2018 |
August 2021 |
August 2021 |
March 29, 2018 |
March 29, 2018 |
|
- Département de Neurologie - Centre des maladies neurologiques, cognitives et comportementales
Paris, France - Hôpital de la Pitié-Salpétrière
Paris, France
|
|
| 57 |
NCT03550131 |
Not yet recruiting |
Innovations in Dementia Empowerment and Action |
- Alzheimer Disease
- Dementia
|
- Behavioral: Innovations in Dementia Empowerment and Action (IDEA)
- Behavioral: Reducing Disabilities in Alzheimer's Disease (RDAD)
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change in Physical Activity of Care Recipient
- Change in Physical Activity of Caregiver
- Change in Physical Functioning of Care Recipient
- (and 7 more...)
|
225 |
All |
50 Years and older (Adult, Older Adult) |
NCT03550131 |
STUDY00003076 |
IDEA |
September 1, 2018 |
December 31, 2020 |
May 31, 2022 |
June 8, 2018 |
June 14, 2018 |
|
|
|
| 58 |
NCT03548584 |
Recruiting |
A Trial to Evaluate the Safety, Efficacy, and Tolerability of Brexpiprazole in Treating Agitation Associated With Dementia of the Alzheimer's Type |
- Agitaton Associated With Alzheimer's Dementia
- Alzheimer Dementia
|
- Drug: Brexpiprazole
- Other: Placebo
|
Interventional
|
Phase 3 |
- Otsuka Pharmaceutical Development & Commercialization, Inc.
- H. Lundbeck A/S
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cohen-Mansfield Agitation Inventory (CMAI) total score
- Clinical Global Impression Severity of Illness (CGI-S) score
|
225 |
All |
55 Years to 90 Years (Adult, Older Adult) |
NCT03548584 |
331-14-213 |
|
May 16, 2018 |
November 2020 |
December 2020 |
June 7, 2018 |
June 7, 2018 |
|
- ATP Clinical Research Inc.
Costa Mesa, California, United States - Neurology Center of North Orange County
Fullerton, California, United States - Arocha Research Center
Coral Gables, Florida, United States - (and 5 more...)
|
|
| 59 |
NCT02886494 |
Recruiting |
A Study to Evaluate Efficacy and Safety of BAC in Patient With Alzheimer's Disease or Vascular Dementia |
- Alzheimer's Disease or Vascular Dementia
|
- Drug: BAC
- Drug: Matched placebo
|
Interventional
|
Phase 2 |
- Charsire Biotechnology Corp.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in Alzheimer Disease Assessment Scale-cognitive (ADAS-cog) score at Week 12 visit compared to baseline
- Change in ADAS-cog score at all post treatment visits (except Week 12 visit) compared to baseline
- Clinician's Interview Based Impression of Change-Plus Caregiver Input (CIBIC-plus) score at all post treatment visits
- (and 4 more...)
|
60 |
All |
40 Years and older (Adult, Older Adult) |
NCT02886494 |
BAC-02 |
|
December 2016 |
November 2018 |
November 2019 |
September 1, 2016 |
March 9, 2018 |
|
- Clinical Research Consortium
Tempe, Arizona, United States - Woodland International Research Group
Little Rock, Arkansas, United States - Woodland Research Northwest, LLC
Rogers, Arkansas, United States - (and 7 more...)
|
|
| 60 |
NCT03491774 |
Not yet recruiting |
Montessori Intervention for Individuals With Dementia: A Feasibility Study From Pakistan |
- Dementia
- Memory Impairment
|
- Behavioral: Montessori Intervention
|
Interventional
|
Not Applicable |
- Pakistan Institute of Living and Learning
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Feasibility of undertaking a trial of the intervention, as determined by:
- Therapy logs
- Montreal Cognitive Examination:
- (and 2 more...)
|
24 |
All |
60 Years and older (Adult, Older Adult) |
NCT03491774 |
PILL-Montessori Dementia |
|
April 20, 2018 |
December 1, 2018 |
December 1, 2018 |
April 9, 2018 |
April 9, 2018 |
|
- Darul Skoun (Older Adult care home)
Karachi, Sindh, Pakistan
|
|
| 61 |
NCT03035851 |
Recruiting |
Aerobic Exercise for Older Adults at Increased Risk of Alzheimer's Disease and Related Dementias |
- Alzheimer Disease
- Dementia
|
- Behavioral: Aerobic exercise
- Behavioral: Stretch and Strength
|
Interventional
|
Not Applicable |
- University of Calgary
- Canadian Institutes of Health Research (CIHR)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Other
|
- Change in Cognition Assessed by Neuropsychological Test Battery
- Change in Cerebral Blood Flow Assessed by Transcranial Doppler Ultrasound
- Change in Maximal Oxygen Uptake (VO2max) Assessed by Metabolic Cart
- (and 5 more...)
|
264 |
All |
50 Years to 80 Years (Adult, Older Adult) |
NCT03035851 |
REB 16-1199 |
BIMII |
January 2017 |
June 2020 |
January 2021 |
January 30, 2017 |
January 16, 2018 |
|
- University of Calgary
Calgary, Alberta, Canada
|
|
| 62 |
NCT02617056 |
Recruiting |
Objective Assessment of Behavioral Associations of Patients With Dementia |
- Dementia
- Psychomotor Agitation
|
|
Observational
|
|
- VA Office of Research and Development
- University of Massachusetts, Worcester
|
U.S. Fed / Other |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
- Electrodermal activity
- Association of behaviors with electrodermal activity
|
60 |
All |
Child, Adult, Older Adult |
NCT02617056 |
N1932-P
RX001932-01 |
|
January 1, 2016 |
December 29, 2019 |
December 29, 2019 |
November 30, 2015 |
March 5, 2018 |
|
- Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA
Bedford, Massachusetts, United States
|
|
| 63 |
NCT02774720 |
Recruiting |
Centre- Versus Home-based Exercise for MCI and Early Dementia |
- Mild Cognitive Impairment
- Dementia
|
- Behavioral: Centre-based exercise
- Behavioral: Home-based exercise
|
Interventional
|
Not Applicable |
- University of Waterloo
- Alzheimer's Association
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Achievement of Physical Activity
- Change in physical activity
- Cost-effectiveness
|
60 |
All |
50 Years and older (Adult, Older Adult) |
NCT02774720 |
20687 |
CHIME |
September 2016 |
November 2018 |
November 2018 |
May 17, 2016 |
June 7, 2017 |
|
- Sunnybrook Research Institute
Toronto, Ontario, Canada - University of Waterloo
Waterloo, Ontario, Canada
|
|
| 64 |
NCT01903421 |
Recruiting |
Inhalational Anesthesia and Precipitation of Dementia: is There a Link? |
- Alzheimer's Disease
- Dementia
|
- Drug: Spinal anesthesia group: bupivacaine 10-15mg
- Drug: General anesthesia group: induction propofol 1.5-2mg/kg and fentanyl 1-3g/kg, maintained with isoflurane or sevoflurane
- Genetic: Blood test
- (and 2 more...)
|
Interventional
|
Not Applicable |
- University Health Network, Toronto
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Assessing the incidence of early dementia
|
500 |
All |
65 Years and older (Older Adult) |
NCT01903421 |
13-6122-A |
|
March 2014 |
December 2018 |
June 2019 |
July 19, 2013 |
January 30, 2018 |
|
- Toronto General Hospital, University Health Network
Toronto, Ontario, Canada - William Osler Health Centre
Toronto, Ontario, Canada - Pauls Stradins Clinical University Hospital
Riga, Latvia
|
|
| 65 |
NCT03033875 |
Recruiting |
Testing Tele-Savvy, an On-line Psychoeducation Program for Dementia Family Caregivers |
- Alzheimer Disease
- Dementia
|
- Behavioral: Tele-Savvy
- Behavioral: Healthy Living Education Program
|
Interventional
|
Not Applicable |
- Emory University
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change in Cornell Scale for Depression in Dementia (CSDD) Score
- Change in Alzheimer's Disease Related Quality of Life (ADRQL) Score
- Change in Perceived Stress Scale (PSS) Score
- (and 10 more...)
|
75 |
All |
18 Years and older (Adult, Older Adult) |
NCT03033875 |
IRB00092812
1R01AG054079-01 |
|
May 18, 2017 |
November 30, 2020 |
November 30, 2020 |
January 27, 2017 |
June 25, 2018 |
|
- Emory University
Atlanta, Georgia, United States
|
|
| 66 |
NCT01330160 |
Recruiting |
Study of Factors Influencing Post-stroke Dementia |
- Cerebrovascular Disorders
- Dementia
|
|
Observational
|
|
- University Hospital, Lille
- Ministry of Health, France
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- dementia occurrence
- dementia occurrence and cognitive impairment
- dementia occurence and cognitive impairment
- cognitive impairment
|
1100 |
All |
40 Years to 95 Years (Adult, Older Adult) |
NCT01330160 |
2008_42/0907
2008/API1901
2009-A00141-56 |
strokdem |
February 27, 2010 |
December 2023 |
December 2023 |
April 6, 2011 |
April 24, 2018 |
|
- Amiens University Hospital
Amiens, France - Caen University Hospital
Caen, France - Lille University Hospital
Lille, France - Rouen University Hospital
Rouen, France
|
|
| 67 |
NCT03293537 |
Recruiting |
Dementia Associated Apathy. |
|
- Diagnostic Test: Skin conductance and Heart rate measurement
|
Interventional
|
Not Applicable |
- Zurich University of Applied Sciences
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Skin conductance
- Heart rate
|
133 |
All |
Child, Adult, Older Adult |
NCT03293537 |
Biomarker and Apathy |
|
October 30, 2017 |
December 31, 2018 |
July 31, 2019 |
September 26, 2017 |
July 16, 2018 |
|
- Zurich University of applied Sciences
Winterthur, Thurgau, Switzerland
|
|
| 68 |
NCT02733939 |
Recruiting |
Technologies to Reduce Caregiver Burden for Informal Caregivers of People With Dementia |
|
- Device: Home monitoring kit
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change from baseline in time spent in informal care at month 3
- Change from baseline in time spent in informal care at month 12
- Change from baseline in Quality of Life of the person with dementia at month 3
- (and 11 more...)
|
320 |
All |
Child, Adult, Older Adult |
NCT02733939 |
2014-4913 |
TECH@HOME |
March 2016 |
December 2018 |
December 2018 |
April 12, 2016 |
February 8, 2018 |
|
- Memory Clinic, Hospital of Ängelholm
Ängelholm, Skåne, Sweden
|
|
| 69 |
NCT03244917 |
Recruiting |
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias |
- Dementia
- Infection, Bacterial
|
|
Interventional
|
Not Applicable |
- Hebrew Rehabilitation Center, Boston
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Total antimicrobial use
- Antimicrobial use when minimal criteria are absent
- Burdensome interventions
- Advance care planning
|
480 |
All |
21 Years and older (Adult, Older Adult) |
NCT03244917 |
TRAIN-AD |
TRAIN-AD |
October 15, 2017 |
August 2020 |
March 2021 |
August 10, 2017 |
November 14, 2017 |
|
- Hebrew SeniorLife
Boston, Massachusetts, United States
|
|
| 70 |
NCT03393520 |
Recruiting |
Assessment of the Efficacy, Safety, and Tolerability of AVP-786 (Deudextromethorphan Hydrobromide [d6 DM]/Quinidine Sulfate [Q]) for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type |
- Agitation in Patients With Dementia of the Alzheimer's Type
|
- Drug: Placebo
- Drug: AVP-786
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline to Week 12 in the Cohen-Mansfield Agitation Inventory (CMAI) Composite Score
- Change from Baseline to Week 12 in the Modified Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change for Agitation (mADCS-CGIC-Agitation) Score
- Change from Baseline to Week 12 in the Neuropsychiatric Inventory (NPI) Agitation/Aggression Domain Score
- (and 11 more...)
|
412 |
All |
50 Years to 90 Years (Adult, Older Adult) |
NCT03393520 |
17-AVP-786-305
2017-001339-38 |
|
October 13, 2017 |
March 2020 |
March 2020 |
January 8, 2018 |
May 24, 2018 |
|
- Australian Alzheimer's Research Foundation
Nedlands, Australia - Neuro Trials Victoria Pty Ltd
Noble Park, Australia - Semmelweis Egyetem
Budapest, Hungary - (and 6 more...)
|
|
| 71 |
NCT03088956 |
Recruiting |
Cognitive, Behavioral, and Functional Change in Behavioral Variant Frontotemporal Dementia (bvFTD) |
- Frontotemporal Dementia
- Behavioral Variant Frontotemporal Dementia
|
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Annualized rate of change in International Shopping List Test (ISLT) - Immediate Recall
- Annualized rate of change in Detection Test
- Annualized rate of change in Identification Test
- (and 57 more...)
|
70 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03088956 |
992FD001 |
FORWARD |
January 19, 2018 |
February 27, 2019 |
March 27, 2019 |
March 24, 2017 |
June 6, 2018 |
|
- Research Site
Birmingham, Alabama, United States - Research Site
Los Angeles, California, United States - Research Site
San Francisco, California, United States - (and 13 more...)
|
|
| 72 |
NCT03620981 |
Recruiting
New |
Brexpiprazole for the Treatment of Patients With Agitation Associated With Dementia of the Alzheimer's Type |
- Agitation Associated With Dementia of the Alzheimer's Type
|
- Drug: Brexpiprazole
- Drug: Placebo
|
Interventional
|
Phase 2
Phase 3 |
- Otsuka Pharmaceutical Co., Ltd.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mean change from baseline in Cohen-Manfield Agitation Incentory(CMAI) score at 10 weeks
- Mean change from baseline in CMAI score at 10 weeks
- Mean change from baseline in Clinical Global Impression of Severity (CGI-S) score at 10 weeks
|
407 |
All |
55 Years to 89 Years (Adult, Older Adult) |
NCT03620981 |
331-102-00088 |
|
August 2018 |
November 2021 |
November 2021 |
August 8, 2018 |
August 8, 2018 |
|
- Yoyogi Mental Clinic
Tokyo, Japan
|
|
| 73 |
NCT02817906 |
Recruiting |
ITI-007 for the Treatment of Agitation in Patients With Dementia, Including Alzheimer's Disease |
- Agitation in Dementia, Including Alzheimer's Disease
|
- Drug: ITI-007
- Drug: Placebo
|
Interventional
|
Phase 3 |
- Intra-Cellular Therapies, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cohen-Mansfield Agitation Inventory - Community Version (CMAI-C)
- Clinical Global Impression Scale for Severity of Illness (CGI-S)
|
360 |
All |
55 Years and older (Adult, Older Adult) |
NCT02817906 |
ITI-007-201 |
|
June 2016 |
August 2018 |
August 2018 |
June 29, 2016 |
November 13, 2017 |
|
- Sun City, Arizona, United States
- Little Rock, Arkansas, United States
- Rogers, Arkansas, United States
- (and 23 more...)
|
|
| 74 |
NCT02862210 |
Recruiting |
Low-Dose Lithium for the Treatment of Behavioral Symptoms in Frontotemporal Dementia |
- Frontotemporal Dementia (FTD)
|
- Drug: Lithium Carbonate
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Columbia University
- Alzheimer’s Drug Discovery Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Reduction in agitation and aggression as measured by the Neuropsychiatric Inventory Scale (NPI)
- Proportion of responders in the lithium and placebo groups
|
60 |
All |
40 Years to 85 Years (Adult, Older Adult) |
NCT02862210 |
NYSPI 7310 |
Lithium |
January 27, 2017 |
September 2019 |
March 2020 |
August 10, 2016 |
April 19, 2017 |
|
- Johns Hopkins University
Baltimore, Maryland, United States - Columbia University Medical Center
New York, New York, United States
|
|
| 75 |
NCT03430401 |
Not yet recruiting |
Computer-based Cognitive Rehabilitation Program for Older People With Mild Cognitive Impairment and Mild Dementia |
- Mild Cognitive Impairment
- Mild Dementia
|
- Behavioral: Perceptual-based memory encoding
- Behavioral: Semantic-based memory encoding
- Behavioral: Cognitive stimulation
|
Interventional
|
Not Applicable |
- University of Western Sydney
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Disability Assessment for Dementia - Change from baseline after the intervention
- Lawton and Brody Instrumental Activities of Daily Living Scale - Change from baseline after the intervention
- Color Trails Test - Change from baseline after the intervention
- (and 2 more...)
|
60 |
All |
65 Years and older (Older Adult) |
NCT03430401 |
UWesternSydney |
|
August 1, 2018 |
July 31, 2019 |
May 1, 2020 |
February 12, 2018 |
February 12, 2018 |
|
- Western Sydney University
Penrith, New South Wales, Australia
|
|
| 76 |
NCT03030027 |
Recruiting |
Connecting Through Caregiving: Reappraising Intergeneration Relationships |
|
- Behavioral: Connecting Through Caregiving
- Other: Basic Skills Building
|
Interventional
|
Not Applicable |
- The Hong Kong Polytechnic University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Center for Epidemiologic Studies Depressive Scale (CESD)
- Change in Zarit Burden Interview (ZBI)
|
80 |
Female |
18 Years to 65 Years (Adult, Older Adult) |
NCT03030027 |
AFC2016 |
CTC |
January 9, 2017 |
December 31, 2020 |
December 31, 2020 |
January 24, 2017 |
June 29, 2018 |
|
- Institute of Active Ageing
Kowloon, Hong Kong
|
|
| 77 |
NCT03507192 |
Recruiting |
Effects of Muscle Relaxation on Cognitive Function in Patients With Mild Cognitive Impairment and Early Stage Dementia. |
- Patients With Mild Cognitive Impairment or Early Alzheimer's Dementia Older Than 50 Years
|
- Device: Muscle relaxation using full body massage machine
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- cortical thickiness in 3D MRI and functional connectivity in functional MRI
|
60 |
All |
50 Years to 90 Years (Adult, Older Adult) |
NCT03507192 |
2017-05-135 |
|
September 25, 2017 |
September 25, 2018 |
September 25, 2018 |
April 24, 2018 |
April 24, 2018 |
|
- Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine
Seoul, Korea, Republic of
|
|
| 78 |
NCT03496675 |
Recruiting |
Music Interventions for Dementia and Depression in Elderly Care |
|
- Behavioral: Group Music Therapy
- Behavioral: Recreational Choir Singing
- Other: Standard care
|
Interventional
|
Not Applicable |
- Uni Research
- University of Melbourne
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Montgomery-Åsberg Depression Rating Scale (MADRS)
- Clinical Dementia Rating (CDR)
- Neuropsychiatric Inventory - Questionnaire (NPI-Q): severity
- (and 9 more...)
|
1000 |
All |
65 Years and older (Older Adult) |
NCT03496675 |
MIDDEL |
MIDDEL |
July 18, 2018 |
April 1, 2020 |
October 1, 2024 |
April 12, 2018 |
July 24, 2018 |
|
- The University of Melbourne
Melbourne, Victoria, Australia
|
|
| 79 |
NCT02446132 |
Recruiting |
Long Term, Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type |
- Agitation in Patients With Dementia of the Alzheimer's Type
|
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of Participants with any Treatment-Emergent Adverse Event
- Number of Participants with any Treatment-Emergent Serious Adverse Event
- Number of Participants with any abnormal, clinically significant Clinical Laboratory Value
- (and 20 more...)
|
700 |
All |
50 Years to 90 Years (Adult, Older Adult) |
NCT02446132 |
15-AVP-786-303 |
|
December 2015 |
March 2021 |
March 2021 |
May 18, 2015 |
May 24, 2018 |
|
- Brain and Spine Center
Chandler, Arizona, United States - Banner Alzheimer's Institute
Phoenix, Arizona, United States - NoesisPharma, LLC
Phoenix, Arizona, United States - (and 152 more...)
|
|
| 80 |
NCT02442765 |
Recruiting |
Efficacy, Safety and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type |
- Agitation in Patients With Dementia of the Alzheimer's Type
|
- Drug: AVP-786
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline to Week 12 in the Cohen-Mansfield Agitation Inventory (CMAI) Composite Score
- Change from Baseline to Week 12 in the Modified Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (mADCS-CGIC)-Agitation (Global Clinical Status of Agitation on mADCS-CGIC Scale) Score
- Change from Baseline to Week 12 in the Neuropsychiatric Inventory (NPI) Agitation/Aggression Domain Score
- (and 13 more...)
|
380 |
All |
50 Years to 90 Years (Adult, Older Adult) |
NCT02442765 |
15-AVP-786-301 |
|
September 2015 |
April 2019 |
April 2019 |
May 13, 2015 |
May 24, 2018 |
|
- NoesisPharma, LLC
Phoenix, Arizona, United States - University of California, Irvine
Irvine, California, United States - Collaborative Neuroscience Network, LLC
Long Beach, California, United States - (and 80 more...)
|
|
| 81 |
NCT03507504 |
Not yet recruiting |
REspectful CAring for the AGitated Elderly |
|
|
Observational
|
|
- Fondazione Europea di Ricerca Biomedica Ferb Onlus
- Mediolanum Cardio Research
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- change of BPSD
- quality of life of patients
- quality of life of caregivers
- cost-effectiveness of SCU-B
|
500 |
All |
Child, Adult, Older Adult |
NCT03507504 |
H2020 Proposal, number: 779237 |
RECAGE |
May 1, 2018 |
December 31, 2021 |
December 31, 2021 |
April 25, 2018 |
April 25, 2018 |
|
- Centre Hospitalier Universitaire St Pierre
Bruxelles, Belgium - Assistance Publique - Hopitaux de Paris
Paris, France - Zentralinstitut für Seelische Gesundheit
Mannheim, Baden-Wurttenberg, Germany - (and 9 more...)
|
|
| 82 |
NCT02442778 |
Recruiting |
Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type |
- Agitation in Patients With Dementia of the Alzheimer's Type
|
- Drug: AVP-786
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline to Week 12 in the Cohen-Mansfield Agitation Inventory (CMAI) Composite Score
- Change from Baseline to Week 12 in the Modified Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (mADCS-CGIC)-Agitation (Global Clinical Status of Agitation on mADCS-CGIC Scale) Score
- Change from Baseline to Week 12 in the Neuropsychiatric Inventory (NPI) Agitation/Aggression Domain Score
- (and 13 more...)
|
470 |
All |
50 Years to 90 Years (Adult, Older Adult) |
NCT02442778 |
15-AVP-786-302 |
|
September 2015 |
December 2019 |
December 2019 |
May 13, 2015 |
May 24, 2018 |
|
- Brain and Spine Center
Chandler, Arizona, United States - Banner Alzheimer's Institute
Phoenix, Arizona, United States - Health Initiatives Research
Fayetteville, Arkansas, United States - (and 71 more...)
|
|
| 83 |
NCT03591822 |
Not yet recruiting
New |
Pilot Study of a Robot-assisted Intervention for the Management of Care-induced Pain in Dementia |
- Moderate to Severe Dementia
|
- Behavioral: A : Systemic evaluation of the pain and mediation with the PARO therapeutic robot
- Behavioral: B : Systemic evaluation of the pain
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
- The Paul Bennetot Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- ALGOPLUS scale
- PACSLAC-F score
- Simple verbal scale (SVS)
- (and 7 more...)
|
80 |
All |
60 Years and older (Adult, Older Adult) |
NCT03591822 |
K170608J |
PARADOL |
July 2018 |
September 2019 |
January 2020 |
July 19, 2018 |
July 19, 2018 |
|
- Résidence Mutualiste " L'adret "
Bellegarde En Forez, France - Résidence Mutualiste " Les Tilleuls "
La Grand Croix, France - Hôpital Broca
Paris, France - (and 2 more...)
|
|
| 84 |
NCT03031184 |
Recruiting |
Study of Mirtazapine or Carbamazepine for Agitation in Dementia |
|
- Drug: Carbamazepine
- Drug: Mirtazapine
- Other: Placebo
|
Interventional
|
Phase 3 |
- University of Sussex
- Norwich Clinical Trials Unit
- University of East Anglia
- (and 8 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cohen Mansfield Agitation Inventory (CMAI) score (Long Form, 29 questions)
|
471 |
All |
18 Years and older (Adult, Older Adult) |
NCT03031184 |
15/SC/0606 |
SYMBAD |
January 2017 |
December 2018 |
August 2019 |
January 25, 2017 |
June 7, 2018 |
|
- Sube Banerjee
Brighton, Sussex, United Kingdom
|
|
| 85 |
NCT03631069 |
Not yet recruiting
New |
Detecting Dementia in the Retina |
- Dementia Alzheimers
- Dementia
- Dementia, Vascular
- Dementia Senile
|
|
Observational
|
|
- Moorfields Eye Hospital NHS Foundation Trust
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Retinal nerve fiber layer thickness
- Ganglion cell layer thickness
- Macular volume
|
200000 |
All |
40 Years and older (Adult, Older Adult) |
NCT03631069 |
KEAP1004 |
|
August 2018 |
August 2019 |
August 2019 |
August 15, 2018 |
August 15, 2018 |
|
- Moorfields Eye Hospital NHS Foundation Trust
London, United Kingdom
|
|
| 86 |
NCT03132272 |
Recruiting |
Immunoadsorption for Treatment of Alzheimer's Disease |
|
- Device: Immunoadsorption with Globaffin
|
Interventional
|
Not Applicable |
- University Medicine Greifswald
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in cerebral blood flow, estimated by Arterial Spin Labeling MRI
- Cognition (changes/improvement/impairment)
- Vascular effects
- (and 2 more...)
|
15 |
All |
55 Years to 85 Years (Adult, Older Adult) |
NCT03132272 |
201503IMAD
CIV-16-02-014668 |
IMAD |
June 2016 |
July 2018 |
July 2018 |
April 27, 2017 |
April 27, 2017 |
|
- University Medicine Greifswald
Greifswald, Mecklenburg-Vorpommern, Germany
|
|
| 87 |
NCT03636204 |
Not yet recruiting
New |
A First in Human Study in Healthy Volunteers and in Participants With Frontotemporal Dementia With Granulin Mutation |
- Healthy
- Frontotemporal Dementia
|
- Biological: AL001
- Other: Placebo
|
Interventional
|
Phase 1 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Evaluation of safety and tolerability of AL001 measured by number of subjects with adverse events and Dose Limiting Adverse Event (DLAEs)
- Pharmacokinetics (PK) of AL001
- Maximum plasma concentration (Cmax) for AL001
- Area under the curve concentration (AUC) for AL001
|
60 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03636204 |
AL001-1 |
|
September 15, 2018 |
March 30, 2020 |
September 30, 2020 |
August 17, 2018 |
August 17, 2018 |
|
- Study site
Orlando, Florida, United States
|
|
| 88 |
NCT03282877 |
Recruiting |
iCST Web-application for People With Dementia |
- Mild Dementia
- Moderate Dementia
|
- Behavioral: iCST web-application
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in cognition (person with dementia)
- Change in quality of life (person with dementia)
- Change in general health outcome (carer)
- (and 5 more...)
|
60 |
All |
21 Years and older (Adult, Older Adult) |
NCT03282877 |
iCST web-application |
|
May 1, 2018 |
February 2019 |
February 2019 |
September 14, 2017 |
May 9, 2018 |
|
- Nottinghamshire Healthcare NHS Trust
Nottingham, United Kingdom
|
|
| 89 |
NCT03360019 |
Not yet recruiting |
Accurate WiFi-Based Localization of Dementia Patients For Caregiver Support: |
- Dementia, Vascular
- Alzheimer Dementia
- Lewy Body Dementia With Behavioral Disturbance
|
- Device: Activlink insole
- Other: Activlink Phone Application
|
Interventional
|
Not Applicable |
- University of Florida
- National Institute on Aging (NIA)
- Aster Labs, Inc
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Caregiver Activity Survey
- Zarit Caregiver Burden scale
- AD Quality of Life Scale
|
204 |
All |
21 Years to 85 Years (Adult, Older Adult) |
NCT03360019 |
IRB201702352 -N
2R44AG046944-02 |
|
September 2018 |
January 2019 |
January 2020 |
December 2, 2017 |
August 9, 2018 |
|
- Oak Hammock Senior Living Center
Gainesville, Florida, United States - Unversity of Florida
Gainesville, Florida, United States
|
|
| 90 |
NCT03578861 |
Recruiting |
Dementia Specific Respite Care Concept. |
- Mobility
- Dementia
- Counseling
- Respite Care
|
- Other: Dementia related mobility and counseling
|
Interventional
|
Not Applicable |
- German Center for Neurodegenerative Diseases (DZNE)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Short Physical Performance Battery (SPPB)
- Nurses' Observation Scale for Geriatric Patients (NOSGER)
- Nurses' Observation Scale for Geriatric Patients (MMST)
- (and 4 more...)
|
30 |
All |
65 Years to 99 Years (Older Adult) |
NCT03578861 |
WI025 |
DESKK |
October 20, 2017 |
September 20, 2018 |
November 1, 2018 |
July 6, 2018 |
July 6, 2018 |
|
|
|
| 91 |
NCT03091855 |
Recruiting |
PLUG Dementia Trial |
- Atrial Fibrillation
- Dementia
- Cognitive Decline
|
|
Observational
|
|
- Intermountain Health Care, Inc.
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Dementia Incidence
- Change in cognitive decline
|
80 |
All |
65 Years and older (Older Adult) |
NCT03091855 |
1050344 |
PLUG |
April 3, 2017 |
April 2019 |
October 2019 |
March 27, 2017 |
April 17, 2018 |
|
- Intermountain Heart Institute
Murray, Utah, United States
|
|
| 92 |
NCT03075007 |
Recruiting |
Brain Vascular Disease in Aging and Dementia |
- Alzheimer Disease
- White Matter Hyperintensities
- Dementia
- Aging
|
- Radiation: Florbetaben F18
- Procedure: Transcranial Doppler
|
Observational
|
|
- Columbia University
- National Institute on Aging (NIA)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- PET amyloid Standard Uptake Value ratio (SUVr) values
- Transcranial Doppler (TCD) dynamic autoregulatory dysfunction
|
20 |
All |
60 Years and older (Adult, Older Adult) |
NCT03075007 |
AAAR1423
2R56AG034189-06A1 |
|
May 23, 2017 |
November 2019 |
November 2019 |
March 9, 2017 |
June 6, 2017 |
|
- Columbia University Medical Center
New York, New York, United States
|
|
| 93 |
NCT02368132 |
Recruiting |
Delivery Models of Caregiver Support and Education |
|
- Behavioral: Group Delivered TEP
- Behavioral: Individual Delivered TEP
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Caregiver Perceived Burden with Zarit Burden Interview
- Caregiver Distress in Response to Dementia-Related Symptoms with Revised Memory and Behavior Problems Checklist
- Caregiver Overall Mental Functioning with the 12 Item Short Form Health Survey (SF12)
|
405 |
All |
18 Years and older (Adult, Older Adult) |
NCT02368132 |
IIR 14-080
01548 |
|
May 13, 2016 |
May 31, 2020 |
May 31, 2020 |
February 20, 2015 |
April 13, 2018 |
|
- VA Western New York Healthcare System, Buffalo, NY
Buffalo, New York, United States - Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
Philadelphia, Pennsylvania, United States
|
|
| 94 |
NCT02781220 |
Recruiting |
Implications for Management of PET Amyloid Classification Technology in the Imaging Dementia(IDEAS) Trial |
- Mild Cognitive Impairment
- Dementia
- Alzheimer's Disease
|
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Percentage of change in care practices after amyloid PET scan
- Percentage of change in drug management options after amyloid PET
- Change in % likelihood of Alzheimer's disease (AD) diagnosis after amyloid PET scan
- (and 12 more...)
|
100 |
All |
65 Years and older (Older Adult) |
NCT02781220 |
IMPACT-2 |
IMPACT2 |
July 2016 |
July 2018 |
July 2019 |
May 24, 2016 |
July 11, 2017 |
|
- Center for Alzheimer's Care, Imaging & Research
Salt Lake City, Utah, United States
|
|
| 95 |
NCT03422250 |
Recruiting |
Non-invasive Stimulation of Brain Networks and Cognition in Alzheimer's Disease and Frontotemporal Dementia |
- Alzheimer Disease
- Frontotemporal Dementia, Behavioral Variant
|
- Device: transcranial direct current stimulation (tDCS)
|
Interventional
|
Not Applicable |
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline in clinical disease severity
- Change from baseline in behavioral symptom severity
- Change from baseline in functional connectivity
- (and 7 more...)
|
60 |
All |
50 Years to 85 Years (Adult, Older Adult) |
NCT03422250 |
GR-2011-02349787 |
NetCogBs |
June 19, 2015 |
November 3, 2018 |
November 3, 2018 |
February 5, 2018 |
August 8, 2018 |
|
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Brescia, Italy
|
|
| 96 |
NCT02956694 |
Recruiting |
Intervention to Improve Shared Decision Making Among Seniors With Dementia, Their Caregivers and Healthcare Providers |
- Dementia
- Professional-Patient Relations
- Professional-Family Relations
- Aging
|
- Behavioral: Training of clinicians + tools
- Other: Usual care
|
Interventional
|
Not Applicable |
- Anik Giguère
- Ministère de l’Économie, de l’Innovation et de l’Exportation du Québec
- SOVAR
- Laval University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Health Services Research
|
- Change in healthcare empowerment of patients (able patient)
- Change in healthcare empowerment of caregivers
- Patient decisional comfort (able patient)
- (and 6 more...)
|
162 |
All |
66 Years and older (Older Adult) |
NCT02956694 |
2014-2015-PSVT2-31404 |
|
October 2016 |
January 2018 |
April 2018 |
November 7, 2016 |
November 7, 2016 |
|
- Réseau de Recherche Axée sur les Pratiques de Première Ligne Université Laval (RRAPPL-UL)
Quebec, Canada
|
|
| 97 |
NCT03284112 |
Not yet recruiting |
Old SCHOOL Hip-Hop: Improve Alzheimer's Disease Knowledge |
|
- Behavioral: Old SCHOOL Hip-Hop
- Behavioral: My Pyramid in Egypt
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in Dementia Symptom and Response Knowledge Assessment Score
|
6000 |
All |
9 Years and older (Child, Adult, Older Adult) |
NCT03284112 |
AAAR5473 |
|
December 2018 |
July 2022 |
July 2022 |
September 15, 2017 |
January 26, 2018 |
|
- Columbia University Medical Center
New York, New York, United States
|
|
| 98 |
NCT03536975 |
Recruiting |
Identify the Benefits CAREGIVERSPRO-MMD Platform Use Based on the Information and Communications Technology, Dedicated to the Support and Assistance of Dyads Living With Neurocognitive Diseases and Their Primary Caregivers |
- Cognitive Impairment, Mild
- Dementia, Mild
|
|
Interventional
|
Not Applicable |
- University Hospital, Rouen
- Centre Hospitalier Intercommunal Elbeuf-Louviers / Val de Reuil
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Burden of primary caregivers
- Quality of life of patients
- Quality of life of caregivers
- (and 9 more...)
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT03536975 |
2016/369/HP |
CAREGIVERSPRO |
December 1, 2017 |
December 31, 2018 |
December 31, 2018 |
May 25, 2018 |
May 25, 2018 |
|
- Centre Hospitalier Intercommunal Elbeuf Louviers
Elbeuf, France - Rouen University Hospital
Rouen, France
|
|
| 99 |
NCT03459118 |
Recruiting |
Dissemination and Implementation of Function Focused Care for Assisted Living |
|
- Behavioral: Function Focused Care
|
Interventional
|
Not Applicable |
- University of Maryland
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Other
|
- Pain Verbal Descriptor Scale
- PAINAD
- Cornell Scale for Depression in Dementia
- (and 6 more...)
|
320 |
All |
Child, Adult, Older Adult |
NCT03459118 |
122345
1R01NR015982-01A1 |
|
September 1, 2017 |
December 30, 2018 |
December 30, 2018 |
March 8, 2018 |
March 9, 2018 |
|
- University of Maryland
Baltimore, Maryland, United States - Penn State University
State College, Pennsylvania, United States
|
|
| 100 |
NCT03040713 |
Recruiting |
Flortaucipir PET Imaging in Subjects With FTD |
|
- Drug: 18F-AV-1451
- Drug: 18F-AV-45
|
Interventional
|
Phase 1 |
- Avid Radiopharmaceuticals
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- 18F-AV-1451 tracer uptake measured by regional SUVr
|
25 |
All |
18 Years and older (Adult, Older Adult) |
NCT03040713 |
18F-AV-1451-A19 |
|
April 11, 2017 |
December 2018 |
December 2018 |
February 2, 2017 |
January 9, 2018 |
|
- Movement Disorder Center, UCSD
La Jolla, California, United States - Memory and Aging Center, UCSF
San Francisco, California, United States - UT Southwestern Medical Center
Dallas, Texas, United States
|
|
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