| 1 |
NCT02787083 |
Recruiting |
A Pilot Study of the Effects of Mirabegron on Symptoms in Patients With Interstitial Cystitis |
|
- Drug: Mirabegron
- Drug: Placebo
|
Interventional |
Phase 3 |
- Philadelphia Urosurgical Associates
- Astellas Pharma Global Development, Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Interstitial Cystitis Symptom Improvement
- Incontinence Measure
- Impact on Quality of life
- (and 3 more...)
|
60 |
Female |
18 Years to 95 Years (Adult, Senior) |
NCT02787083 |
MYRB-15G02 |
MirabegronIC |
August 2016 |
December 2018 |
December 2018 |
June 1, 2016 |
January 19, 2018 |
|
- Philadelphia Urosurgical Associates
Philadelphia, Pennsylvania, United States
|
| 2 |
NCT03104361 |
Not yet recruiting |
Platelet-Rich Plasma (PRP) Injection in Treatment of Interstitial Cystitis |
|
- Biological: Platelet-Rich Plasma
|
Interventional |
Phase 1 |
- Buddhist Tzu Chi General Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- O'Leary-Sant Symptom Score
- Visual analog score (VAS) for pain
- Functional bladder capacity (FBC)
- Voiding frequency
|
30 |
All |
20 Years and older (Adult, Senior) |
NCT03104361 |
TCGH10548A |
|
April 2017 |
June 2018 |
July 2018 |
April 7, 2017 |
April 7, 2017 |
|
- Buddhist Tzu Chi General Hospital
Hualien, Taiwan
|
| 3 |
NCT02331472 |
Recruiting |
The Efficacy of Urine Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome (Pilot Study) |
- Chronic Interstitial Cystitis
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Difference of RNA expression of the urine biomarker between the interstitial cystitis and control groups
- Difference of RNA expression of the urine biomarker between Hunner ulcer interstitial cystitis and non-ulcer interstitial cystitis groups
- Difference of RNA expression of the urine biomarker in interstitial cystitis according to pain score on the visual analogue scale
|
75 |
All |
20 Years and older (Adult, Senior) |
NCT02331472 |
2014-1220 |
|
January 2015 |
December 2017 |
December 2017 |
January 6, 2015 |
July 11, 2017 |
|
- Asan Medical Center
Seoul, Korea, Republic of
|
| 4 |
NCT03290261 |
Recruiting |
Hypnosis as a Therapeutic Tool in Patients With Reccurent Cystitis |
|
|
Interventional |
Not Applicable |
- Centre Hospitalier Universitaire de Nice
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Score at HAD Scale
- Score at Pain evaluation scale
- Evolution of HAD scale score
- (and 5 more...)
|
15 |
Female |
18 Years and older (Adult, Senior) |
NCT03290261 |
16-PP-10 |
HYPNOCYST |
August 8, 2017 |
August 8, 2019 |
August 8, 2019 |
September 21, 2017 |
January 16, 2018 |
|
- Hôpital Archet
Nice, France
|
| 5 |
NCT03468530 |
Recruiting |
Therapeutic Effects of Endoscopic Ablation of Hunner Lesions in Interstitial Cystitis/ Bladder Pain Syndrome Patients |
|
- Procedure: Transurethral ablation
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- change in recurrence-free survival time after ablation treatment
- changes in mean number of daytime frequency episodes
- changes in mean number of nocturia episodes
- (and 6 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT03468530 |
2017-08-005 |
|
August 1, 2012 |
July 31, 2018 |
July 31, 2019 |
March 16, 2018 |
March 16, 2018 |
|
- Samsung Medical Center, Sungkyunkwan University School of Medicine
Seoul, Korea, Republic of
|
| 6 |
NCT03129126 |
Not yet recruiting |
The Safety, Tolerability and Efficacy of LP-10 With Placebo in Subjects With Refractory Moderate to Severe Hemorrhagic Cystitis |
|
|
Interventional |
Phase 2 |
- Lipella Pharmaceuticals, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Patient Reported Mean episodes of visible blood
- Urine Dipstick Mean episodes of Visible Blood
- Mean urine hemoglobin concentration
- (and 10 more...)
|
18 |
All |
18 Years and older (Adult, Senior) |
NCT03129126 |
Safety and Efficacy of LP-10 1 |
|
December 2017 |
December 2018 |
February 2019 |
April 26, 2017 |
April 26, 2017 |
|
|
| 7 |
NCT03463499 |
Recruiting |
The Efficacy and Safety of Intravesical Hyaluronic Acid and Chondroitin Sulfate After Transurethral Resection of Hunner Lesion in Interstitial Cystitis/Bladder Pain Syndrome Patients |
|
- Drug: Hyaluronic Acid and Chondroitin Sulfate
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- change in recurrence rate in Hyaluronic Acid and Chondroitin Sulfate instillation group after transurethral resection treatment
- changes in mean number of daytime frequency episodes
- changes in mean number of nocturia episodes
- (and 6 more...)
|
62 |
All |
20 Years and older (Adult, Senior) |
NCT03463499 |
2017-08-106 |
|
September 22, 2017 |
September 30, 2019 |
January 1, 2022 |
March 13, 2018 |
March 13, 2018 |
|
- Samsung Medical Center, Sungkyunkwan University School of Medicine
Seoul, Korea, Republic of
|
| 8 |
NCT03003845 |
Not yet recruiting |
S1P1 Receptor Subtype (S1PR1) Axis in Patients With Interstitial Cystitis (IC) Pain |
|
- Other: Questionnaires
- Other: Collection of Blood samples
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Change From Baseline in Pain Scores on the Visual Analog Scale at 6 months
|
50 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT03003845 |
27338 |
S1P1 |
September 1, 2018 |
September 1, 2019 |
November 1, 2019 |
December 28, 2016 |
April 9, 2018 |
|
|
| 9 |
NCT02150811 |
Recruiting |
Observational Study of Hunner's Ulcer in Patient With Interstitial Cystitis/Bladder Pain Syndrome |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change of distribution pattern of Hunner's ulcer
|
30 |
All |
20 Years and older (Adult, Senior) |
NCT02150811 |
20131119 |
|
March 2014 |
December 2017 |
December 2017 |
May 30, 2014 |
July 7, 2017 |
|
- Asan Medical Center
Seoul, Korea, Republic of
|
| 10 |
NCT01985880 |
Recruiting |
The Efficacy of Biomarker in Patient With Interstitial Cystitis/Painful Bladder Syndrome |
|
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- To compare of expression of the biomarker such as APF, HB-EGF, MCP-1 among the Hunner's ulcer interstitial cystitis and non-ulcer interstitial cystitis and control groups
- To compare of changes voiding parameters after bladder biopsy between Hunner' ulcer group and non-ulcer group
- TO compare of change of scores of questionnaires such as O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q), Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF), Visual Analogue Scale (Pain) between Hunner's ulcer group and non-ulcer group
|
30 |
All |
20 Years and older (Adult, Senior) |
NCT01985880 |
2013-0616 |
|
November 2013 |
November 2018 |
December 2018 |
November 15, 2013 |
January 16, 2018 |
|
- Asan Medical Center
Seoul, Korea, Republic of - Asan medical center Institutional review board
Seoul, Korea, Republic of
|
| 11 |
NCT01659723 |
Recruiting |
Radiation Induced Cystitis Treated With Hyperbaric Oxygen - A Randomized Controlled Trial |
|
|
Interventional |
Phase 2
Phase 3 |
- Göteborg University
- Sahlgrenska University Hospital, Sweden
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- EPIC (Expanded Prostate cancer Index Composite)
- Microscopic assessment
- RTOG (Radiation Toxicity Grade by Radiation Therapy Oncology Group)
- (and 2 more...)
|
80 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01659723 |
RICH-ART 2012-001381-15
2012-001381-15 |
RICH-ART |
August 2012 |
December 2017 |
December 2017 |
August 8, 2012 |
February 2, 2017 |
|
- Rigshospitalet Copenhagen
Copenhagen, Denmark - Haukeland Universitetssykehus
Bergen, Norway - Shalgrenska University Hospial
Gothenburg, Sweden - (and 3 more...)
|
| 12 |
NCT01813565 |
Recruiting |
The Efficacy of Additional Intravesical Instillation of Hyaluronic Acid/Chondroitin Sulfate to Transurethral Resection of Bladder Ulcer in Patients With Interstitial Cystitis/Bladder Pain Syndrome. |
|
- Drug: Hyaluronic acid/chondroitin sulfate
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change of pain scores on the Visual Analogue Scale
- Duration of symptom improvement
- Changes of frequency and urgency on voiding diary
- (and 6 more...)
|
32 |
All |
20 Years and older (Adult, Senior) |
NCT01813565 |
20130135 |
|
March 2013 |
March 2013 |
November 2018 |
March 19, 2013 |
January 16, 2018 |
|
- Asan medical center
Seoul, Korea, Republic of
|
| 13 |
NCT01393223 |
Recruiting |
Evaluation of Intravesical LP08 in Patients With Interstitial Cystitis/Painful Bladder Syndrome |
|
- Drug: LP-08 80mg
- Drug: Normal Saline Placebo
- Drug: LP-08 20mg
|
Interventional |
Phase 2 |
- Lipella Pharmaceuticals, Inc.
- William Beaumont Hospitals
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Safety
- Efficacy Voids Per Day (VPD)
- Efficacy Global Response Assessment (GRA)
- (and 3 more...)
|
36 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01393223 |
PhaseII LP-08 IC/BPS |
|
April 2015 |
April 2018 |
June 2018 |
July 13, 2011 |
September 12, 2017 |
|
- William Beaumont Hospitals
Royal Oak, Michigan, United States
|
| 14 |
NCT03008382 |
Recruiting |
Interstitial Cystitis: Examination of the Central Autonomic Network |
- Interstitial Cystitis/Painful Bladder Syndrome
- Myofascial Pelvic Pain
|
- Drug: Metoprolol Tartrate Oral Tablet
- Drug: Placebo Oral Tablet
|
Interventional |
Phase 4 |
- Medical College of Wisconsin
- NorthShore University HealthSystem
- Case Western Reserve University
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Correlation between the change in Autonomic Nervous System Responsiveness (ANS-R) and the change in the connectivity between prefrontal cortex (PFC) and periaqueductal gray (PAG)
|
180 |
Female |
18 Years to 80 Years (Adult, Senior) |
NCT03008382 |
PRO25031 |
ICECAN |
March 1, 2017 |
July 2020 |
July 2022 |
January 2, 2017 |
January 29, 2018 |
|
- NorthShore University HealthSystem
Evanston, Illinois, United States - Case Western Reserve University
Cleveland, Ohio, United States - Medical College of Wisconsin
Milwaukee, Wisconsin, United States
|
| 15 |
NCT03425396 |
Recruiting |
Oral Omadacycline vs. Oral Nitrofurantoin for the Treatment of Cystitis |
- Uncomplicated Urinary Tract Infection
- Cystitis
|
- Drug: Omadacycline; po tablets
- Drug: Nitrofurantoin, po capsules
|
Interventional |
Phase 2 |
- Paratek Pharmaceuticals Inc
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Investigator's assessment of clinical response at Post Treatment Evaluation (PTE) based on microbiological response.
- Investigator's assessment of clinical response at Post Treatment Evaluation (PTE) based on subject's report of UTI signs and symptoms.
- Investigator's assessment of clinical response at Post Treatment Evaluation (PTE) based on subject's report of health and adverse events.
|
200 |
Female |
18 Years and older (Adult, Senior) |
NCT03425396 |
PTK0796-UUTI-17201 |
|
December 28, 2017 |
March 2019 |
March 2019 |
February 7, 2018 |
March 29, 2018 |
|
- Site 106
Chula Vista, California, United States - Site 101
La Mesa, California, United States - Site 109
Los Angeles, California, United States - (and 12 more...)
|
| 16 |
NCT01311479 |
Recruiting |
Osteopathic Manipulation for Female Interstitial Cystitis Patients With Sacroiliac Joint Dysfunction |
- Interstitial Cystitis
- Sacroiliac Joint Somatic Dysfunction
|
- Procedure: Osteopathic Manipulation Therapy
|
Interventional |
Not Applicable |
- Pelvic and Sexual Health Institute
- Interstitial Cystitis Association
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement in Scores of Validated questionnaires pertaining to Interstitial Cystitis problems and symptoms
|
40 |
Female |
18 Years and older (Adult, Senior) |
NCT01311479 |
OMT-09 |
|
November 2009 |
October 2017 |
October 2018 |
March 9, 2011 |
April 14, 2014 |
|
- Pelvic and Sexual Health Institute
Philadelphia, Pennsylvania, United States
|
| 17 |
NCT03282318 |
Recruiting |
A Study to Investigate Efficacy, Safety, Pharmacodynamics and Pharmacokinetics of ASP6294 in the Treatment of Female Subjects With Bladder Pain Syndrome/Interstitial Cystitis |
- Bladder Pain Syndrome
- Interstitial Cystitis
|
- Drug: ASP6294
- Drug: Placebo
|
Interventional |
Phase 2 |
- Astellas Pharma Europe B.V.
- Astellas Pharma Inc
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in average mean daily pain (MDP) at Visit 6/Week 12
- Change from baseline in average worst daily pain (WDP) at Visit 6/Week 12
- Change from baseline in mean voiding frequency at Visit 6/Week 12
- (and 11 more...)
|
163 |
Female |
18 Years and older (Adult, Senior) |
NCT03282318 |
6294-CL-0101
2016-004138-12 |
SERENITY |
September 28, 2017 |
May 2019 |
May 2019 |
September 13, 2017 |
April 18, 2018 |
|
- Site BE32001
Leuven, Belgium - Site BE32002
Edegem, Czechia - Site CZ42001
Kromeriz, Czechia - (and 39 more...)
|
| 18 |
NCT02868775 |
Recruiting |
A Study to Determine the Role of Toll-like Receptor-4 Expression in Patients With Interstitial Cystitis/Bladder Pain Syndrome |
- Cystitis, Interstitial
- Painful Bladder Syndrome
|
- Procedure: cystoscopy, bladder hydrodistention and bladder biopsy
|
Observational |
|
- Philadelphia Urosurgical Associates
- Drexel University College of Medicine
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Toll-like Receptor 4 protein analysis
- Toll-like Receptor 4 mRNA expression in bladder biopsy
- Toll-like Receptor 4 distribution and localization evaluation
- (and 5 more...)
|
60 |
Female |
18 Years to 90 Years (Adult, Senior) |
NCT02868775 |
TLR4001 |
|
September 2016 |
June 2017 |
October 2017 |
August 16, 2016 |
January 6, 2017 |
|
- Hahnemann Urogynecology
Philadelphia, Pennsylvania, United States
|
| 19 |
NCT03463915 |
Not yet recruiting |
Efficacy Study of Bladder Instillation and Gabapentin on Interstitial Cystitis/Bladder Pain Syndrome. |
- Interstitial Cystitis
- Bladder Pain Syndrome
|
- Drug: Gabapentin Pill
- Drug: Placebo oral capsule
|
Interventional |
Phase 3 |
- Olivia Cardenas-Trowers, M.D.
- University of Louisville
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in treatment response as measured by the total score on the O'Leary-Sant questionnaire
- Pelvic pain and urgency/frequency (PUF) questionnaire
- Overactive bladder questionnaire (OAB-q)
- (and 5 more...)
|
80 |
Female |
18 Years and older (Adult, Senior) |
NCT03463915 |
18.0209 |
|
June 2018 |
June 2019 |
June 2019 |
March 13, 2018 |
April 11, 2018 |
|
|
| 20 |
NCT02517996 |
Recruiting |
Use of Preemptive Pudendal Nerve Block Prior to Hydrodistention for the Treatment of Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) |
- Interstitial Cystitis
- Painful Bladder Syndrome
|
- Drug: Lidocaine
- Drug: Placebo
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Visual Analog Scale (VAS)
- Change in IC Symptom Index Questionnaire with Preemptive Pudendal Nerve Block Compared to Saline
- Change in Problem Index (O'Leary Sant) with Preemptive Pudendal Nerve Block Compared to Saline
- (and 4 more...)
|
60 |
Female |
18 Years and older (Adult, Senior) |
NCT02517996 |
IRB00034476 |
|
February 2015 |
February 2018 |
February 2018 |
August 7, 2015 |
April 25, 2017 |
|
- Greater Baltimore Medical Center
Baltimore, Maryland, United States - Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States
|
| 21 |
NCT02591199 |
Recruiting |
Engage 24: Evaluation of the Safety and Effectiveness of URG101 in Subjects With Interstitial Cystitis/Bladder Pain Syndrome |
- Interstitial Cystitis
- Bladder Pain Syndrome
|
- Drug: URG101
- Drug: Placebo
- Drug: Lidocaine
- Drug: Heparin
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in bladder pain differences from baseline as determined by using the Visual Analog Scale (VAS)
- Change in urgency from baseline using the VAS
- The relationship of plasma lidocaine concentrations at 1 hour after study drug administration to bladder pain and urgency
- Safety and tolerability of study medication (Adverse events)
|
348 |
All |
18 Years and older (Adult, Senior) |
NCT02591199 |
URG101-105 |
|
September 2015 |
December 2017 |
December 2017 |
October 29, 2015 |
May 4, 2017 |
|
- IC Study, LLC
Escondido, California, United States - University of California San Diego
San Diego, California, United States - Scripps Clinic
San Diego, California, United States - (and 8 more...)
|
| 22 |
NCT03023241 |
Recruiting |
Diagnosis of Bladder Pain Syndrome / Interstitial Cystitis |
- Bladder Pain Syndrome
- Interstitial Cystitis
- Overactive Bladder
|
|
Interventional |
Not Applicable |
- Cantonal Hospital, Frauenfeld
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Identification of new diagnostic markers for BPS/IC
- Identification of molecular details that lead to BPS/IC (pathogenesis).
|
300 |
Female |
18 Years to 90 Years (Adult, Senior) |
NCT03023241 |
9900.013 BPS/IC study
KEKTGOV2010/01 |
|
December 2004 |
December 2019 |
December 2019 |
January 18, 2017 |
February 7, 2018 |
|
- Cantonal Hospital Frauenfeld
Frauenfeld, Thurgau, Switzerland
|
| 23 |
NCT00389142 |
Recruiting |
Genetic Studies in Interstitial Cystitis (IC) |
- Interstitial Cystitis
- Painful Bladder Syndrome
- Chronic Pelvic Pain Syndrome
|
|
Observational |
|
- Boston Children’s Hospital
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
|
500 |
All |
up to 100 Years (Child, Adult, Senior) |
NCT00389142 |
04-11-160
91208 |
|
January 15, 2006 |
December 31, 2020 |
December 31, 2021 |
October 18, 2006 |
August 1, 2017 |
|
- Children's Hospital
Boston, Massachusetts, United States
|
| 24 |
NCT02870738 |
Recruiting |
Bladder Directed vs. Pelvic Floor Therapy in IC/BPS |
- Cystitis, Interstitial
- Painful Bladder Syndrome
|
- Procedure: Pelvic Floor Physical Therapy
- Drug: Bladder Instillations
|
Interventional |
Phase 2 |
- William Beaumont Hospitals
- Baylor College of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Markedly/Moderately Improved on Global Response Assessments
- Change in symptoms
|
128 |
Female |
18 Years to 85 Years (Adult, Senior) |
NCT02870738 |
2016-253 |
|
April 21, 2017 |
August 2019 |
August 2020 |
August 17, 2016 |
March 6, 2018 |
|
- William Beaumont Hospital
Royal Oak, Michigan, United States
|
| 25 |
NCT03076762 |
Recruiting |
Comparative Study Suburothelial and Trigonal Botulinum Toxin A Injection in Treatment of Interstitial Cystitis |
|
- Drug: intravesical onabotulinumtoxinA injection
|
Interventional |
Phase 2 |
- Buddhist Tzu Chi General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Reduction of bladder pain visual analog scale (VAS)
- Interstitial cystitis symptom index (ICSI)
- Functional bladder capacity
- (and 4 more...)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT03076762 |
BuddhistTCGH2003-01 |
|
March 2015 |
August 2017 |
August 2017 |
March 10, 2017 |
April 7, 2017 |
|
- Buddhist Tzu Chi General Hospital
Hualien, Taiwan
|
| 26 |
NCT03493997 |
Recruiting
New |
Multicentre International STudy for the Prevention With Ialuril® of Radio-induced Cystitis (MISTIC) |
|
- Combination Product: Radiotherapy+IAluril®+Ialuril Soft Gels®
- Radiation: Radiotherapy only
|
Interventional |
Phase 2 |
- Study Group for Urogenital Diseases, Italy
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Rate of patients
- comparative analysis of score between the two groups through ICIQ
- comparative analysis of score between the two groups through EPIC
- (and 2 more...)
|
100 |
Male |
18 Years and older (Adult, Senior) |
NCT03493997 |
MISTIC |
MISTIC |
April 4, 2017 |
December 31, 2018 |
December 31, 2019 |
April 11, 2018 |
April 18, 2018 |
|
- Ospedali Careggi
Firenze, Italy - Università "Vita-Salute" San Raffaele
Milano, Italy - University of Palermo, Italy
Palermo, Italy - (and 4 more...)
|
| 27 |
NCT02747420 |
Recruiting |
PTNS Versus Sham Efficacy in Treatment of BPS |
- Interstitial Cystitis Bladder Pain Syndromes
|
- Device: NURO TM
- Device: Sham
|
Interventional |
Not Applicable |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Patient Global Impression of Improvement (PG-I)
- Visual Analog Scale (VAS)
- O'Leary-Sant Pain Scores
- (and 2 more...)
|
100 |
Female |
18 Years and older (Adult, Senior) |
NCT02747420 |
15-01447 |
|
June 2016 |
June 2018 |
June 2018 |
April 21, 2016 |
February 8, 2018 |
|
- New York University School of Medicine
New York, New York, United States
|
| 28 |
NCT03379389 |
Not yet recruiting |
Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis |
|
- Drug: Methenamine + Methylthioninium
- Drug: Methenamine + Methylthioninium + Acriflavine + Atropa belladona
- Drug: Antibiotics
|
Interventional |
Phase 4 |
- Fundação Educacional Serra dos Órgãos
- Laboratório Gross S.A.
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Urination regularity
- Total UTISA score
- UTISA question # 9
- (and 7 more...)
|
284 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03379389 |
AUCR-01-05-17 |
|
March 31, 2018 |
May 1, 2019 |
May 1, 2020 |
December 20, 2017 |
March 14, 2018 |
|
|
| 29 |
NCT03032003 |
Not yet recruiting |
Prophylactic Use of Cranberries in Recurrent Bacterial Cystitis in Women |
- Recurrent Urinary Tract Infections in Women
|
- Other: Cysticlean
- Other: Placebo
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Effectiveness of the use of Cranberries in the prevention of the recurrent UTIs is women.
|
160 |
Female |
18 Years to 85 Years (Adult, Senior) |
NCT03032003 |
Cranberries1 |
|
February 15, 2017 |
March 31, 2018 |
May 31, 2018 |
January 26, 2017 |
January 26, 2017 |
|
|
| 30 |
NCT02814864 |
Not yet recruiting |
Trial Evaluating the Efficacy of Systemic Mesenchymal Stromal Cell (MSC) Injections for the Treatment of Severe and Chronic Radiotherapy-induced Abdomino-pelvic Complications (Pelvic Radiation Disease, PRD) Refractory to Standard Therapy |
- Pelvic Radiation Therapy
- Radiation-induced Hemorrhagic Cystitis
|
- Other: Mesenchymal Stromal Cell (MSC) injections
|
Interventional |
Phase 2 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Decrease of one grade on the LENT SOMA
- The effect of treatment on analgesic drug consumption (analgesic, opiates).
- The effect of treatment on quality of life with SF36 questionnaire
- (and 3 more...)
|
12 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02814864 |
P130935
2014-001462-99 |
PRISME |
April 2017 |
May 2017 |
January 2018 |
June 28, 2016 |
March 22, 2017 |
|
- Hématologie et thérapie cellulaire, Hôpital Saint Antoine
Paris, France
|
| 31 |
NCT02555059 |
Recruiting |
Special Drug Use Investigation of Ciproxan Injection in Pediatrics |
- Cystitis / Pyelonephritis / Cystic Fibrosis / Anthrax
|
- Drug: Cipro (Ciprofloxacin, BAYQ3939)
|
Observational |
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of musculoskeletal adverse events.
- Existence of Bacillus anthracis or Escherichia coli or Pseudomonas aeruginosa in urine(Y/N)
- Number of participants with adverse events as measure of safety and tolerability
- (and 2 more...)
|
45 |
All |
up to 14 Years (Child) |
NCT02555059 |
18235 |
|
July 15, 2016 |
September 30, 2018 |
September 30, 2018 |
September 21, 2015 |
April 3, 2018 |
|
- Multiple Locations, Japan
|
| 32 |
NCT02898220 |
Recruiting |
Trans-MAPP II Study of Urologic Chronic Pelvin Pain |
- Interstitial Cystitis
- Chronic Prostatitis
|
|
Observational |
|
- University of Pennsylvania
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Colorado, Denver
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Pain Severity Score
- Urinary Severity Score
|
72 |
All |
18 Years and older (Adult, Senior) |
NCT02898220 |
825428
U01DK082316 |
|
September 2016 |
December 2018 |
December 2018 |
September 13, 2016 |
September 13, 2016 |
|
- University of California, Los Angeles (UCLA)
Los Angeles, California, United States - Northwestern University
Chicago, Illinois, United States - University of Iowa
Iowa city, Iowa, United States - (and 3 more...)
|
| 33 |
NCT02514265 |
Recruiting |
Trans-MAPP Symptom Patterns Study (SPS) |
- Interstitial Cystitis
- Chronic Prostatitis
|
|
Observational |
|
- University of Pennsylvania
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Colorado, Denver
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Pain Severity Score
- Urinary Severity Score
|
640 |
All |
18 Years and older (Adult, Senior) |
NCT02514265 |
822352
5U01DK082316-02 |
MAPP II SPS |
July 1, 2015 |
January 2019 |
June 2019 |
August 3, 2015 |
February 27, 2018 |
|
- University of California Los Angeles/University of Southern California
Los Angeles, California, United States - Northwestern University
Chicago, Illinois, United States - University of Iowa
Iowa City, Iowa, United States - (and 3 more...)
|
| 34 |
NCT02781103 |
Recruiting |
Guided Imagery and Transcranial Direct Current Stimulation (tDCS) in Women With Chronic Pelvic Pain |
- Cystitis, Interstitial
- Pelvic Pain
|
- Other: Guided imagery plus active tDCS
- Other: Guided imagery plus Sham tDCS
|
Interventional |
Not Applicable |
- Kenneth M Peters, MD
- William Beaumont Hospitals
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change in alpha wave frequency on EEG
- Change in pain levels on a 0-10 (no pain to most severe pain) Visual Analog Scale (VAS)
|
20 |
Female |
18 Years to 64 Years (Adult) |
NCT02781103 |
2016-117 |
|
September 2016 |
August 2019 |
August 2020 |
May 24, 2016 |
March 9, 2018 |
|
- Beaumont Hospital-Royal Oak
Royal Oak, Michigan, United States
|
| 35 |
NCT03275623 |
Not yet recruiting |
Management of Sub-Clinical Bacteriuria in Pregnancy |
- Cystitis
- Cystitis;Puerperium
- Pyelonephritis
|
- Drug: Antibiotic
- Other: Standard Prenatal Care
|
Interventional |
Phase 4 |
- The University of Texas Health Science Center, Houston
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants who have cystitis
- Number of participants who have pyelonephritis
|
50 |
Female |
18 Years and older (Adult, Senior) |
NCT03275623 |
HSC-MS-17-0294 |
|
September 15, 2017 |
July 15, 2018 |
July 15, 2018 |
September 7, 2017 |
September 7, 2017 |
|
- The University of Texas Health Science Center at Houston
Houston, Texas, United States
|
| 36 |
NCT03143920 |
Recruiting |
Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder |
- Chronic Interstitial Cystitis
- Painful Bladder Syndrome
- Recurrent Urinary Tract Infection
|
- Combination Product: Hyperbaric Oxygen Therapy-
|
Interventional |
Early Phase 1 |
- University of California, San Diego
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- HBOT acceptance
- HBOT adherence
- Pre and post treatment symptom survey for the chronic interstitial cystitis study group.
- (and 3 more...)
|
40 |
Female |
35 Years to 70 Years (Adult, Senior) |
NCT03143920 |
HBOTurology.2017 |
HBOTCICrUTI |
October 25, 2017 |
June 1, 2020 |
October 30, 2020 |
May 8, 2017 |
October 26, 2017 |
|
- Hillcrest Hosptial
San Diego, California, United States
|
| 37 |
NCT03480477 |
Not yet recruiting
New |
Adverse Childhood Experiences in Urogynecologic Patients |
- Pelvic Floor Disorders
- Interstitial Cystitis
- Urinary Incontinence
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Prevalence
- Describe the frequency and ACE types/domains
|
600 |
Female |
18 Years and older (Adult, Senior) |
NCT03480477 |
18-010 |
ACE-UP |
April 9, 2018 |
June 1, 2019 |
June 1, 2019 |
March 29, 2018 |
April 9, 2018 |
|
|
| 38 |
NCT03042273 |
Recruiting |
High Strength Cranberry Supplementation for Prevention of Recurrent Urinary Tract Infection |
|
- Dietary Supplement: High Strength Cranberry
- Dietary Supplement: Placebo
|
Interventional |
Not Applicable |
- Swisse Wellness Pty Ltd
- Commonwealth Scientific and Industrial Research Organisation, Australia
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
|
300 |
Female |
18 Years to 65 Years (Adult) |
NCT03042273 |
PAC-001 |
|
May 15, 2017 |
November 2018 |
June 2019 |
February 3, 2017 |
February 28, 2018 |
|
- Holdsworth House Medical Centre
Sydney, New South Wales, Australia - Holdsworth House Medical Centre
Brisbane, Queensland, Australia - CSIRO Nutrition and Health Research Clinic
Adelaide, South Australia, Australia
|
| 39 |
NCT03362697 |
Not yet recruiting |
Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women |
- Urinary Tract Infection in Pregnancy
|
- Dietary Supplement: Probiotics
- Drug: Antibiotics
|
Interventional |
Not Applicable |
- Innovacion y Desarrollo de Estrategias en Salud
- BioGaia AB
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Clinical and/or Bacteriological cure
- Recurrence rate
- Time to relapse
- (and 4 more...)
|
150 |
Female |
18 Years to 40 Years (Adult) |
NCT03362697 |
CSUB 0139 |
UTIPregnant |
December 15, 2017 |
August 30, 2018 |
September 30, 2018 |
December 5, 2017 |
December 18, 2017 |
|
- Hospital General Dr. Manuel Gea Gonzalez
Mexico city, Tlalpan, Mexico
|
| 40 |
NCT01738464 |
Recruiting |
Microbiomes of Pelvic Pain |
- Interstitial Cystitis
- Chronic Prostatitis
- Chronic Pelvic Pain Syndrome
- (and 3 more...)
|
|
Observational |
|
- Northwestern University
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Genotype Anaerobic Bacterial populations between Control patients and patients diagnosed with Interstitial Cystitis or Chronic Prostatitis/Chronic Pelvic Pain Syndrome, Lower Urinary Tract Symptoms, Overactive Bladder, and Major Depression
- Separate serum from blood specimen given by Control patients and patients diagnosed with Interstitial Cystitis or Chronic Prostatitis/Chronic Pelvic Pain Syndrome, Lower Urinary Tract Symptoms, Overactive Bladder, and Major Depression
- Collect urine specimen from Control patients and patients diagnosed with Interstitial Cystitis or Chronic Prostatitis/Chronic Pelvic Pain Syndrome, Lower Urinary Tract Symptoms, Overactive Bladder, and Major Depression
|
300 |
All |
18 Years to 60 Years (Adult) |
NCT01738464 |
STU00055668
1R01DK103769-01A1 |
|
June 2012 |
March 7, 2019 |
March 8, 2019 |
November 30, 2012 |
February 27, 2018 |
|
- Northwestern University
Chicago, Illinois, United States
|
| 41 |
NCT02214550 |
Recruiting |
Chronic Pain Risk Associated With Menstrual Period Pain |
- Cystitis, Interstitial
- Dysmenorrhea
- Migraine Disorders
- (and 4 more...)
|
|
Interventional |
Phase 4 |
- NorthShore University HealthSystem Research Institute
- National Institutes of Health (NIH)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Change in participant bladder pain sensitivity from baseline.
- Change in Quantitative Sensory Testing (QST) parameters regarding pelvic hyperalgesia from baseline
- Differences in EEG recorded cortical activity among participants
|
255 |
Female |
18 Years to 45 Years (Adult) |
NCT02214550 |
EH13-094
1R01DK100368-01 |
CRAMPP |
July 2014 |
September 2019 |
September 2025 |
August 12, 2014 |
February 2, 2018 |
|
- NorthShore University Health System
Evanston, Illinois, United States
|
| 42 |
NCT03108079 |
Recruiting |
Bladder Morphology Using 2 Different Catheter Designs |
- Urologic Injuries
- Urologic Diseases
- Bladder Infection
- (and 9 more...)
|
- Device: Cystosure Urinary Access System
- Device: Foley Catheter
|
Interventional |
Not Applicable |
- The Pelvic Floor Institute
- Cystosure
- Innovative Research Inc.
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Bladder shape after emptying
|
3 |
Female |
21 Years to 70 Years (Adult, Senior) |
NCT03108079 |
03082017 |
|
April 2017 |
May 2017 |
June 2017 |
April 11, 2017 |
April 12, 2017 |
|
- The Pelvic Floor Institute
Tampa, Florida, United States
|
| 43 |
NCT00499317 |
Recruiting |
Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) |
- Chronic Prostatitis (CP)
- Chronic Pelvic Pain Syndrome (CPPS)
- Painful Bladder Syndrome (PBS)
- (and 2 more...)
|
|
Observational |
|
- Boston Children’s Hospital
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
|
500 |
Male |
Child, Adult, Senior |
NCT00499317 |
04-11-160M
91208 |
CP/CPPS |
January 15, 2007 |
December 31, 2020 |
December 31, 2021 |
July 11, 2007 |
August 1, 2017 |
|
- Children's Hospital, Boston
Boston, Massachusetts, United States
|
| 44 |
NCT02832258 |
Recruiting |
Urinary Tract Infection Due to Beta-lactamase-producing Enterobacteriaceae in Children |
|
|
Observational |
|
- Fouad Madhi
- Centre Hospitalier Intercommunal Creteil
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- First and second lines used antibiotic therapies
- Resistance patterns of ESBL types in the isolates
- Clinical characteristics (fewer, clinical sepsis) of E-ESBL UTI in children
- (and 9 more...)
|
800 |
All |
up to 18 Years (Child, Adult) |
NCT02832258 |
PYELOBLSE |
PYELOBLSE |
March 2014 |
March 2018 |
March 2019 |
July 14, 2016 |
July 31, 2017 |
|
- Antoine Beclère Hospital
Clamart, Ile-de France, France - Jean Verdier Hospital
Bondy, Ile-de-France, France - André Mignot Hospital
Le Chesnay, Ile-de-France, France - (and 22 more...)
|
| 45 |
NCT01953523 |
Recruiting |
Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions |
- Neurodegenerative Diseases
- Osteoarthritis
- Erectile Dysfunction
- (and 3 more...)
|
- Procedure: Administration of autologous adipose derived SVF
|
Interventional |
Not Applicable |
- Elliot Lander
- Cell Surgical Network Inc.
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with adverse events
- Changes in the Oswestry Disability Index
- Changes in the Neck Disability Index
- (and 9 more...)
|
3000 |
All |
16 Years and older (Child, Adult, Senior) |
NCT01953523 |
CSN111 |
|
March 2012 |
March 2018 |
March 2018 |
October 1, 2013 |
June 15, 2016 |
|
- California Stem Cell Treatment Center
Rancho Mirage, California, United States
|
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