| 1 |
NCT02824744 |
Not yet recruiting |
Comparison Between 2l vs 3l in HFNC During the Initial Management of Severe Bronchiolitis in Infants |
|
- Device: treatment by 2l/min/kg in High Flow Nasal cannula (HFNC)
- Device: treatment by 3l/min/kg in High Flow Nasal cannula (HFNC)
|
Interventional |
Phase 3 |
- University Hospital, Montpellier
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of failure in both arms
- assessment of heart rate in both arm
- Assessment of the discomfort in both arms with the score of EDIN
- (and 2 more...)
|
270 |
All |
up to 6 Months (Child) |
NCT02824744 |
9719 |
TRAMONTANE2 |
October 2016 |
October 2017 |
October 2017 |
July 7, 2016 |
July 7, 2016 |
|
- University hospital of Montpellier
Montpellier, France
|
| 2 |
NCT03015051 |
Recruiting |
High Flow Nasal Cannula vs Low Flow Oxygen Therapy in Bronchiolitis |
|
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Hours of oxygen therapy
- Number of subject admitted in intensive care unit
- Number of patients needing intubation
- (and 2 more...)
|
130 |
All |
up to 6 Months (Child) |
NCT03015051 |
High flow RCT |
|
January 2017 |
January 2018 |
January 2018 |
January 9, 2017 |
January 16, 2017 |
|
- Ospedale Maggiore
Bologna, Emilia Romagna, Italy - Ospedale Morgagni-Pierantoni
Forlì, Emilia Romagna, Italy - Ospedale Ravenna AUSL Romagna
Ravenna, Emilia Romagna, Italy - (and 12 more...)
|
| 3 |
NCT02947204 |
Recruiting |
Oxygen Saturation Monitoring in Bronchiolitis |
|
- Other: Intermittent oxygen monitoring
- Other: Continuous oxygen monitoring
|
Interventional |
Not Applicable |
- The Hospital for Sick Children
- Canadian Institutes of Health Research (CIHR)
- Children's Hospital of Eastern Ontario
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Supportive Care
|
- Length of hospital stay from randomization on the inpatient unit to discharge from hospital
- Duration of oxygen supplementation from randomization to discontinuation of supplementation
- Number of medical interventions performed from time of randomization to hospital discharge
- (and 10 more...)
|
210 |
All |
up to 24 Months (Child) |
NCT02947204 |
1000054699 |
|
November 2016 |
November 2018 |
November 2018 |
October 27, 2016 |
October 18, 2017 |
|
- McMaster Children's Hospital
Hamilton, Ontario, Canada - Trillium Health Partners (Credit Valley Site)
Mississauga, Ontario, Canada - Lakeridge Health Oshawa
Oshawa, Ontario, Canada - (and 3 more...)
|
| 4 |
NCT02890797 |
Not yet recruiting |
Assessment of Thoracic Echography for Pleuroparenchymatous Anomaly Diagnosis Complicating Bronchiolitis: BronchioIUS |
|
|
Interventional |
Not Applicable |
- University Hospital, Toulouse
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Presence of parenchymatous opacity
- Radiological anomaly
- Parenchymatous retractable (or non retractable) opacity
|
143 |
All |
up to 2 Years (Child) |
NCT02890797 |
RC31/15/7858 |
BronchioIUS |
March 2018 |
April 2019 |
April 2019 |
September 7, 2016 |
March 7, 2018 |
|
- Hôpital des Enfants, Unité de pneumo-allergologie pédiatrique
Toulouse, France
|
| 5 |
NCT03354325 |
Recruiting |
The Bronchiolitis Follow-up Intervention Trial |
|
- Behavioral: Scheduled PCP follow-up
- Behavioral: As needed PCP follow-up
|
Interventional |
Not Applicable |
- University of Utah
- Stanford University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Parental anxiety
- Time from hospital discharge to cough resolution
- Time from hospital discharge to child reported back to normal
- (and 11 more...)
|
294 |
All |
up to 2 Years (Child) |
NCT03354325 |
82296 |
BeneFIT |
January 1, 2018 |
May 10, 2019 |
June 20, 2019 |
November 27, 2017 |
April 12, 2018 |
|
- Packard El Camino Hospital
Mountain View, California, United States - Lucile Packard Children's Hospital
Palo Alto, California, United States - Intermountain Riverton Hospital
Riverton, Utah, United States - Primary Children's Hospital
Salt Lake City, Utah, United States
|
| 6 |
NCT02856165 |
Recruiting |
High-flow Nasal Oxygen Therapy in Hospitalized Infant With Moderate-to-severe Bronchiolitis |
|
- Device: High-flow nasal canula oxygen therapy
- Device: Low-flow oxygen therapy with standard nasal canula
|
Interventional |
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- patient in treatment failure in each group (control or HFN) requiring non-invasive (or endotracheal) ventilation and ventilation-support free days
- Transfer to pediatrics intensive care unit (PICU)
- Length of stay in paediatric general ward unit
- (and 3 more...)
|
276 |
All |
up to 6 Months (Child) |
NCT02856165 |
P150931 |
BRONCHOPTI |
October 2016 |
March 2018 |
April 2018 |
August 4, 2016 |
March 1, 2017 |
|
- AP-HP, Bicêtre Hospital
Le Kremlin Bicêtre, France
|
| 7 |
NCT02737280 |
Recruiting |
High Flow Nasal Cannula Use in Infants With Bronchiolitis |
|
- Device: Airvo (TM, Fisher & Paykel Healthcare) - High flow oxygen therapy
- Device: MedKit Finland - Usual oxygen therapy
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of patients with treatment failure
- Respiratory rate measured by the study physician/nurse
- Oxygen saturation (%)
- (and 3 more...)
|
160 |
All |
up to 6 Months (Child) |
NCT02737280 |
EETTMK2015 |
|
March 2016 |
March 2019 |
March 2020 |
April 13, 2016 |
October 25, 2017 |
|
- Central Hospital Jyväskylä
Jyväskylä, Finland - Oulu Unversity Hospital
Oulu, Finland - Seinäjoki Central Hospital
Seinäjoki, Finland - Tampere University Hospital
Tampere, Finland
|
| 8 |
NCT03361371 |
Not yet recruiting |
Suctioning of NOse Therapy Versus Usual Home Care in Bronchiolitis |
|
- Device: Battery operated nasal aspirator
|
Interventional |
Not Applicable |
- The Hospital for Sick Children
- The Physicians' Services Incorporated Foundation
- Children's Hospital of Eastern Ontario
- London Health Sciences Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Treatment failure as measured by questionnaire administered on day 7
- Unscheduled, i.e. family-initiated return medical visit for bronchiolitis as measured by questionnaire administered on day 7
- Emergency Department re-visit as measured by questionnaire administered on day 7
- (and 4 more...)
|
412 |
All |
up to 12 Months (Child) |
NCT03361371 |
1000059068 |
SNOT |
February 1, 2018 |
April 30, 2021 |
April 30, 2022 |
December 4, 2017 |
December 7, 2017 |
|
|
| 9 |
NCT02913040 |
Recruiting |
High Flow in Infants With Bronchiolitis |
|
- Other: High Flow Nasal Cannula
- Other: Low Flow Nasal Prongs
|
Interventional |
Not Applicable |
- Princess Amalia Children's Clinic
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- PEWS (Pediatric Early Warning Score) (in points 0-28)
- Comfort (in points 0-10)
- ability to feed (yes or no)
- (and 2 more...)
|
118 |
All |
up to 24 Months (Child) |
NCT02913040 |
High Flow in Bronchiolitis |
|
December 1, 2016 |
April 1, 2018 |
May 1, 2018 |
September 23, 2016 |
January 4, 2018 |
|
- Isala Klinieken
Zwolle, Overijssel, Netherlands - Amphia
Breda, Netherlands - Deventer Ziekenhuis
Deventer, Netherlands - (and 4 more...)
|
| 10 |
NCT02984046 |
Recruiting |
Acute Bronchiolitis and Severity Markers: Interest in Protein CC16 |
|
|
Interventional |
Not Applicable |
- University Hospital, Clermont-Ferrand
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Serum CC16 rate
- Urinary CC16 rate
- SP-D rates
- sRAGE rates
|
200 |
All |
up to 1 Year (Child) |
NCT02984046 |
CHU-0294
2015-A01587-42 |
CC16 |
November 2015 |
August 2018 |
January 2019 |
December 6, 2016 |
December 6, 2016 |
|
- CHU Clermont-Ferrand
Clermont-Ferrand, France
|
| 11 |
NCT03492307 |
Not yet recruiting
New |
Weight-based Flow Rates for Children With Bronchiolitis on High-Flow Nasal Cannula: A Pilot Randomized Control Trial |
|
- Other: Weight-Based Flow for High Flow Nasal Cannula (HFNC) (2L/kg/minute)
- Other: Standard Flow for HFNC (Maximum 8L/minute)
|
Interventional |
Not Applicable |
- Boston Children’s Hospital
- South Shore Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Treatment failure
- Length of Stay
|
120 |
All |
up to 2 Years (Child) |
NCT03492307 |
IRB-P00028533 |
|
May 1, 2018 |
April 30, 2019 |
April 30, 2019 |
April 10, 2018 |
April 10, 2018 |
|
|
| 12 |
NCT03053388 |
Recruiting |
Evaluation of the Efficacy Safety and Tolerability of Nitric Oxide Given Intermittently Via Inhalation to Subjects With Bronchiolitis |
|
- Drug: Nitric Oxide
- Other: Supportive treatment
|
Interventional |
Phase 3 |
- Advanced Inhalation Therapies Ltd
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Hospital Length of Stay (LOS)
- Clinical score of ≤5 (Modified Tal score).
- Oxygen saturation (SaO2) ≥92% in room air (without oxygen supplementation) sustained for at least 2 hours
- Adverse events and NO-related adverse events including methemoglobinemia and nitrogen dioxide levels.
|
120 |
All |
up to 12 Months (Child) |
NCT03053388 |
AIT_CP_BRONC02.01 |
|
March 5, 2017 |
April 19, 2018 |
June 19, 2018 |
February 15, 2017 |
February 15, 2018 |
|
- Haemek Medical Center
Afula, Israel - Barzili Medical Center
Ashkelon, Israel - Soroka Medical Center
Beer Sheva, Israel - (and 7 more...)
|
| 13 |
NCT03037801 |
Recruiting |
Intrapulmonary Percussive Ventilation for Children With Bronchiolitis on Non-Invasive Ventilation Support |
|
- Device: Intrapulmonary Percussive Ventilation (Percussionaire Corp, Sandpoint, Idaho)
|
Interventional |
Not Applicable |
- Soroka University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Length of PICU Stay
- Need for Invasive Ventilation Support
- S/F ratio
- Prevention of lung atelectasis
|
50 |
All |
up to 2 Years (Child) |
NCT03037801 |
SOR-0074-16 CTIL |
|
March 1, 2017 |
May 2018 |
July 2018 |
January 31, 2017 |
June 2, 2017 |
|
- Soroka Medical Center
Beer Sheva, Israel
|
| 14 |
NCT02708147 |
Not yet recruiting |
Impact of Respiratory Physiotherapy in Children With Bronchiolitis in the First Two Years of Life |
|
- Other: Physiotheraphy + Conventional treatment
- Other: Conventional treatment
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Computerized lung sounds
- Wang severity scale
|
52 |
All |
up to 2 Years (Child) |
NCT02708147 |
PhDPT/VeronicaAbreu/2016 |
|
October 2017 |
March 2018 |
March 2018 |
March 15, 2016 |
July 5, 2017 |
|
|
| 15 |
NCT02760719 |
Recruiting |
The Effectiveness of Nebulized Hypertonic Saline Solution for Acute Bronchiolitis |
|
- Drug: nebulized 3% hypertonic solution
|
Interventional |
Phase 2 |
- University Medical Centre Ljubljana
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Fit to discharge time
- Duration of hospitalisation
- Duration of hypoxia
- (and 7 more...)
|
100 |
All |
1 Month to 24 Months (Child) |
NCT02760719 |
22k/12/12 |
NHSAB |
December 2015 |
December 2017 |
December 2017 |
May 4, 2016 |
May 18, 2016 |
|
- Department of infectious disease, University Medical Centre, Ljubljana
Ljubljana, Slovenia
|
| 16 |
NCT02093715 |
Recruiting |
FeNO and Cytokines in Respiratory Syncytial Virus (RSV) and Non RSV Bronchiolitis in Relation to Future Asthma |
|
|
Observational |
|
- Tel-Aviv Sourasky Medical Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Physician diagnosed asthma
- Fractional exhaled Nitric Oxide (FENO) level
|
400 |
All |
up to 2 Years (Child) |
NCT02093715 |
TASMC-13-YS-07-075-CTIL |
|
July 2007 |
August 2020 |
|
March 21, 2014 |
September 3, 2014 |
|
- Sourasky Medical Center
Tel-Aviv, Israel
|
| 17 |
NCT03280732 |
Recruiting |
Use of Lung Ultrasound in Children With Acute Bronchiolitis |
|
|
Interventional |
Not Applicable |
- Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- LUS vs CXR in diagnosing pulmonary complications in bronchiolitis
- Sonographer inter-observer agreement
- LUS and severity of bronchiolitis
|
150 |
All |
up to 24 Months (Child) |
NCT03280732 |
13/2016/O/Sper |
|
February 2016 |
April 2018 |
September 2018 |
September 12, 2017 |
January 17, 2018 |
|
- Pediatric Emergency Unit, S. Orsola-Malpighi Hospital
Bologna, BO, Italy
|
| 18 |
NCT02219334 |
Recruiting |
Comparing Nasal Suction Devices in Children With Bronchiolitis: A Pilot Study |
|
|
Interventional |
Not Applicable |
- Baylor College of Medicine
- Texas Children's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percentage of (NoseFrida) patients discharged home before the current mean length of stay of 25.7 hours.
- Number of participants with serious and non-serious adverse events
|
150 |
All |
2 Months to 2 Years (Child) |
NCT02219334 |
H-33659 |
|
September 2014 |
May 2018 |
May 2018 |
August 18, 2014 |
July 7, 2017 |
|
- Texas Children's Hospital
Houston, Texas, United States
|
| 19 |
NCT03364218 |
Not yet recruiting |
"Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use: A Randomized Controlled Trial" Inpatient Hospital Use: A Randomized Controlled Trial" |
|
- Drug: N acetyl cysteine nebulized
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Symptoms compared to the standard supportive care: using the bronchiolitis scoring system.
- Reduce duration spend on non-invasive ventilation
- Decrease PICU/hospital stay.
|
106 |
All |
up to 2 Years (Child) |
NCT03364218 |
IRB# 2314 |
|
December 2017 |
May 2020 |
May 2020 |
December 6, 2017 |
December 6, 2017 |
|
|
| 20 |
NCT03298217 |
Recruiting |
Peak Tidal Inspiratory Flow in Infants With Moderate to Severe Acute Viral Bronchiolitis |
|
- Device: Measurement of the peak tidal inspiratory flow (PTIF)
|
Interventional |
Not Applicable |
- University Hospital, Montpellier
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Measurement of peak or peak inspiration flow (PTIF=peak tidal inspiratory flow)
- Proportion of patients with a spontaneous PTIF higher than 2 L/kg/min
- Correlation between PTIF and Silverman score
- (and 4 more...)
|
50 |
All |
up to 6 Months (Child) |
NCT03298217 |
UF9868 |
DEBIB |
November 6, 2017 |
April 1, 2018 |
July 1, 2018 |
October 2, 2017 |
November 7, 2017 |
|
- Uhmontpellier
Montpellier, France
|
| 21 |
NCT03252119 |
Recruiting |
High Flow Oxygen Therapy vs Standard Care in Infants With Viral Bronchiolitis |
|
- Device: High flow humidified oxygen therapy
|
Interventional |
Not Applicable |
- Chris Hani Baragwanath Academic Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effect of high flow humidified oxygen therapy on work of breathing
- Effect of high flow humidified oxygen therapy on blood oxygen saturations
- Effect of high flow humidified oxygen therapy on heart rate
- (and 2 more...)
|
130 |
All |
1 Month to 2 Years (Child) |
NCT03252119 |
M170234 |
|
June 1, 2017 |
August 2019 |
April 2020 |
August 17, 2017 |
August 17, 2017 |
|
- Chris Hani Baragwanath Academic Hospital
Johannesburg, Gauteng, South Africa
|
| 22 |
NCT02458274 |
Recruiting |
Microparticles and Bronchiolitis Obliterans Syndrome |
|
- Other: Dosage of Microparticles (MPs) in broncho-alveolar lavage fluid (BALF)
|
Observational |
|
- University Hospital, Strasbourg, France
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Correlation between total concentration of MPs in broncho-alveolar lavage fluid (BALF) and occurrence of bronchiolitis obliterans syndrome at three year post lung transplantation
- Total concentration MPs and characterization of cellular origin of MPs in BALF and in plasma of patients at three year post lung transplantation.
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02458274 |
5254 |
MIBO |
July 2014 |
January 2019 |
January 2019 |
June 1, 2015 |
June 1, 2015 |
|
- CHU Strasbourg
Strasbourg, France
|
| 23 |
NCT02618213 |
Recruiting |
Comparison of High Flow Oxygenation Therapy and CPAP in Children With Bronchiolitis. |
- Respiratory Syncytial Virus Bronchiolitis
|
- Device: Optiflow Junior
- Device: Continous Positive Airway Pressure
|
Interventional |
Phase 4 |
- Hospital of South West Denmark
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- respiration rate
- PCo2
- Modified asthma score (MWAS)
- (and 4 more...)
|
48 |
All |
up to 24 Months (Child) |
NCT02618213 |
S-20150007 |
|
December 2015 |
June 2018 |
June 2018 |
December 1, 2015 |
August 24, 2017 |
|
- Signe Vahlkvist
Kolding, Denmark
|
| 24 |
NCT03436225 |
Not yet recruiting |
Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy. |
- Bronchiolitis; Respiratory Syncytial Virus
|
- Drug: Dexamethasone orally.
- Drug: Dexamethasone parenteral.
- Drug: Inhaled nebulized Budesonide.
- Drug: Inhaled nebulized salbutamol.
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Resolution of respiratory distress.
- Reduction of mean duration of symptoms.
- Reduction of duration of oxygen therapy.
- Reduction of average Length of hospital stay.
|
80 |
All |
3 Months to 2 Years (Child) |
NCT03436225 |
Steroid in bronchiolitis. |
|
February 2018 |
February 2019 |
March 2019 |
February 16, 2018 |
February 20, 2018 |
|
|
| 25 |
NCT03072849 |
Recruiting |
Early Detection and Management of Bronchiolitis Obliterans Syndrome Following Pediatric Hematopoietic Stem Cell Transplantation |
- Bronchiolitis Obliterans Syndrome
|
- Procedure: Pulmonary function testing
- Drug: FAM Therapy
|
Observational |
|
- Ann & Robert H Lurie Children's Hospital of Chicago
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Lung function
- Survival
- Risk factor assessment
|
40 |
All |
6 Years to 18 Years (Child, Adult) |
NCT03072849 |
SCT 1214 BOS |
|
April 2015 |
April 2017 |
April 2019 |
March 7, 2017 |
March 7, 2017 |
|
- Ann & Robert H Lurie Children's Hospital of Chicago
Chicago, Illinois, United States
|
| 26 |
NCT03346850 |
Not yet recruiting |
Comparison Between Gastric and Post Pyloric Tube Feedings in Children With Bronchiolitis Requiring High Flow Nasal Cannula |
- Enteral Feeding in Bronchiolitis
|
- Device: Nasogastric tube (NGT) feeding
- Device: Nasoduodenal tube (NDT) feeding
|
Interventional |
Not Applicable |
- The University of Texas Health Science Center, Houston
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Other
|
- Length of high flow nasal cannula (HFNC) therapy
- Number of emesis
- Peak respiratory support in liters per minute
- (and 3 more...)
|
250 |
All |
up to 12 Months (Child) |
NCT03346850 |
HSC-MS-17-0725 |
|
December 1, 2018 |
December 1, 2018 |
December 1, 2018 |
November 17, 2017 |
November 17, 2017 |
|
- The University of Texas Health Science Center at Houston
Houston, Texas, United States
|
| 27 |
NCT02977585 |
Recruiting |
Helmet Continuous Positive Airway Pressure Support for Severe Bronchiolitis in PICUs |
- Critically Ill Severe Bronchiolitis
|
|
Interventional |
Not Applicable |
- Bambino Gesù Hospital and Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- incidence of intubation following Helmet CPAP treatment
- incidence of pneumothorax following Helmet CPAP treatment
- length of stay
|
488 |
All |
38 Weeks to 18 Months (Child) |
NCT02977585 |
1239_OPBG_2016 |
|
November 2016 |
May 2017 |
May 2018 |
November 30, 2016 |
November 30, 2016 |
|
- Bambino Gesù Children's Hospital
Rome, Lazio, Italy
|
| 28 |
NCT03095495 |
Not yet recruiting |
High Flow Nasal Cannula Therapy in Bronchiolitis : Early vs Rescue |
- Bronchiolitis
- Respiratory Syncytial Virus (RSV)
|
- Device: Heated Humidified High Flow Nasal Cannula
- Device: Standard Therapy (Low Flow Nasal Cannula)
|
Interventional |
Not Applicable |
- Hamad Medical Corporation
- Sidra Medical and Research Center
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- The rate of Pediatric Intensive Care Unit (PICU) admissions
- Mean length of stay (LOS)
- Bronchiolitis Severity Score (BSS)
- (and 3 more...)
|
350 |
All |
up to 3 Months (Child) |
NCT03095495 |
16036/16 |
|
January 2018 |
May 2020 |
June 2020 |
March 29, 2017 |
August 11, 2017 |
|
|
| 29 |
NCT03288857 |
Recruiting |
Comparison of the Bulb Aspirator to a Nasal Oral Aspirator in the Treatment of Bronchiolitis |
|
|
Interventional |
Not Applicable |
- University of Texas at Austin
- Dell Children’s Medical Center of Central Texas
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Unscheduled bronchiolitis return visits
- Oral intake
- Respiratory relief
- (and 2 more...)
|
440 |
All |
1 Month to 24 Months (Child) |
NCT03288857 |
2017-06-0086 |
|
November 22, 2017 |
June 2019 |
June 2019 |
September 20, 2017 |
November 29, 2017 |
|
- Dell Children's Medical Center of Central Texas
Austin, Texas, United States
|
| 30 |
NCT02911935 |
Recruiting |
Azithromycin to Prevent Wheezing Following Severe RSV Bronchiolitis-II |
- Respiratory Syncytial Virus, Bronchiolitis
|
- Drug: Oral azithromycin
- Drug: Placebo
|
Interventional |
Phase 2
Phase 3 |
- Washington University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The occurrence of a third episode of post-RSV wheezing
- Physician diagnosis of asthma
- Days with respiratory symptoms (wheezing, cough, or shortness of breath), or albuterol use
- (and 4 more...)
|
188 |
All |
1 Month to 18 Months (Child) |
NCT02911935 |
201603018 |
APW-RSV-II |
November 2016 |
April 2021 |
September 2021 |
September 22, 2016 |
May 17, 2017 |
|
- Department of Pediatrics, Washington University School of Medicine; and St. Louis Children's Hospital
Saint Louis, Missouri, United States
|
| 31 |
NCT01273207 |
Recruiting |
Extension Study (Extended Access) of Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans |
- Bronchiolitis Obliterans
- Constructive Bronchiolitis
- Graft Versus Host Disease
|
- Drug: Inhaled Cyclosporine Solution
|
Interventional |
Phase 2 |
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Primary endpoints include the toxicity profile (adverse events) and efficacy of extended use CIS for BO/BOS
- Secondary endpoints include improvement in chest CT images, results of peripheral blood and bronchoalveolar cytokine arrays, and functional capacity measurements
- Toxicity profile (adverse events)
|
78 |
All |
10 Years to 80 Years (Child, Adult, Senior) |
NCT01273207 |
110064
11-H-0064 |
|
February 1, 2011 |
June 30, 2025 |
June 30, 2025 |
January 10, 2011 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 32 |
NCT03315741 |
Recruiting |
The Safety and Tolerability of Pirfenidone for BOS After HCT |
- Bronchiolitis Obliterans
- Graft Vs Host Disease
|
- Drug: Pirfenidone 267 MG [Esbriet]
|
Interventional |
Phase 1 |
- Stanford University
- Genentech, Inc.
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The number of participants that do not require a reduction in drug dose for more than 21 days due to adverse events.
- The number of participants that permanently discontinue drug due to adverse events.
- The number of participants that temporarily discontinue drug due to adverse events.
- (and 12 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03315741 |
VAR0158
IRB-43319 |
STOP-BOS |
March 1, 2018 |
January 31, 2020 |
March 31, 2020 |
October 20, 2017 |
March 20, 2018 |
|
- Stanford University School of Medicine
Palo Alto, California, United States
|
| 33 |
NCT02109237 |
Recruiting |
Sleep Disorders in Bronchiolitis Obliterans Syndrome 2&3 |
- Bronchiolitis Obliterans
- Sleep Disordered Breathing Central
|
- Procedure: Assessment of sleep disorders and treatment if required
|
Interventional |
Not Applicable |
- The Prince Charles Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- To Measure Prevalence of sleep disorders in Bronchiolitis Obliterans 2&3 patients
- Quality of life assessment using Rand SF36 standard survey
|
75 |
All |
18 Years and older (Adult, Senior) |
NCT02109237 |
HREC/13/QPCH/217 |
|
May 2014 |
September 2018 |
September 2019 |
April 9, 2014 |
May 3, 2017 |
|
- The Prince Charles Hospital
Brisbane, Queensland, Australia
|
| 34 |
NCT03062917 |
Recruiting |
Nasal and Bronchial Absorption Sampling in RSV Bronchiolitis |
- Bronchiolitis
- Bronchiolitis, Viral
- RSV Infection
- Respiratory Failure
|
- Diagnostic Test: Nasal and Bronchial Sampling
|
Interventional |
Not Applicable |
- Imperial College Healthcare NHS Trust
- Pulmocide Ltd
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Tolerability
- Accuracy
- Sensitivity, specificity, quantitation Utility for RSV-A vs RSV-B using Viral load by qPCR
- (and 2 more...)
|
80 |
All |
up to 2 Years (Child) |
NCT03062917 |
15/WM/0343 |
RSV-SAM |
October 2, 2015 |
April 30, 2017 |
April 30, 2017 |
February 24, 2017 |
February 24, 2017 |
|
- Imperial College NHS Healthcare Trust
London, United Kingdom
|
| 35 |
NCT02669251 |
Recruiting |
AZD9668, an Oral Neutrophil Elastase Inhibitor, in Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation |
- Chronic Graft vs Host Disease
- Chronic Graft-Versus-Host-Disease
- Bronchiolitis Obliterans Syndrome
|
|
Interventional |
Phase 1
Phase 2 |
- National Cancer Institute (NCI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Optimal biologic dose (OBD) based on maximal NE inhibition measured in sputum
- To determine the clinical efficacy of AZD9668 at the OBD in patients with BOS after SCT
- determine the safety of AZD9668
- (and 6 more...)
|
34 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02669251 |
160060
16-C-0060 |
|
January 29, 2016 |
September 30, 2018 |
September 30, 2019 |
February 1, 2016 |
February 14, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 36 |
NCT03283007 |
Not yet recruiting |
Nintedanib in Lung Transplant Recipients With Bronchiolitis Obliterans Syndrome Grade 1-2 |
- Lung-transplant Recipients
|
- Drug: Nintedanib
- Drug: Placebo
|
Interventional |
Phase 3 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Nintedanib efficacy in the reduction of the rate of decline of FEV1 (forced expiratory volume in 1 sec) in BOS post-LTx at a dose of 150 mg twice daily (bid) compared to placebo over 6 months
- Nintedanib efficacy on exercise tolerance in LTx recipients
- Nintedanib efficacy on quality of life improvement in LTx recipients
- (and 5 more...)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT03283007 |
AOR16076 - P160907 |
INFINITx-BOS |
April 2018 |
April 2021 |
November 2021 |
September 14, 2017 |
September 14, 2017 |
|
|
| 37 |
NCT02262299 |
Recruiting |
European Trial of Pirfenidone in BOS, A European Multi-center Study |
- Disorder Related to Lung Transplantation
- CLAD, Bronchiolitis Obliterans
|
- Drug: Pirfenidone
- Drug: Placebo
|
Interventional |
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- To evaluate the effect of Pirfenidone on the change in FEV1 in liters over 6 months in lung transplant recipients with bronchiolitis obliterans syndrome.
- - Categorical percentage change in FEV1
- - Change in Forced Vital Capacity (FVC)
- (and 9 more...)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT02262299 |
RH-HJE-2014-09 |
EPOS |
May 2015 |
October 2018 |
October 2019 |
October 13, 2014 |
December 12, 2016 |
|
- University Hospital Gasthuisberg, Katholike Universiteit Leuven
Leuven, Belgium - Rigshospitalet, Copenhagen University Hospital
Copenhagen, Denmark - University Hospital Essen, Department of Pneumonology
Essen, Germany - (and 8 more...)
|
| 38 |
NCT03035097 |
Recruiting |
Deployment-Related Lung Disease Research Database and Biorepository |
|
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Other
|
- collect symptom and exposure data
|
500 |
All |
18 Years and older (Adult, Senior) |
NCT03035097 |
HS-2689 |
|
February 2013 |
February 2019 |
February 2019 |
January 27, 2017 |
April 20, 2018 |
|
- National Jewish Health
Denver, Colorado, United States
|
| 39 |
NCT00177918 |
Recruiting |
Prospective Evaluations of Infectious Complication in Lung Transplant Recipients |
- Disorder Related to Lung Transplantation
- Bronchiolitis Obliterans
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- long term outcome after lung transplantation
|
600 |
All |
18 Years and older (Adult, Senior) |
NCT00177918 |
IRB # 0212095 |
|
August 2006 |
December 2025 |
December 2025 |
September 15, 2005 |
June 12, 2017 |
|
- University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
|
| 40 |
NCT03237364 |
Recruiting |
Iraq- Afghanistan War Lung Injury Using 19F MRI (DIAL1001006) |
- Constrictive Bronchiolitis
- Iraq-Afganistan War Lung Injury Syndrome
|
- Diagnostic Test: Perfluorinated Gas/Oxygen Mixture
|
Interventional |
Early Phase 1 |
- Hal C Charles
- Duke University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Lung Ventilatory Heterogeneity defined by parametric imaging with 19F perfluorinated gas/oxygen mixtures
|
10 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT03237364 |
Pro00076112 |
|
August 19, 2017 |
October 10, 2018 |
October 10, 2018 |
August 2, 2017 |
April 19, 2018 |
|
- Duke Image Analysis Laboratory
Durham, North Carolina, United States
|
| 41 |
NCT02543073 |
Recruiting |
MSC for Treatment of Interstitial Lung Disease After Allo-HSCT |
- Lung Diseases, Interstitial
- Hematopoietic Stem Cell Transplantation
- Bronchiolitis Obliterans
|
- Biological: MSCs
- Drug: AZM
- Drug: Glucocorticoid
|
Interventional |
Phase 1
Phase 2 |
- Nanfang Hospital of Southern Medical University
- Sun Yat-sen University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Response rate of ILD
- Overall Survival
|
60 |
All |
18 Years to 65 Years (Adult) |
NCT02543073 |
MSC-ILD-2015 |
|
September 2014 |
December 2017 |
June 2018 |
September 7, 2015 |
May 10, 2017 |
|
- Department of Hematology,Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
|
| 42 |
NCT02962505 |
Recruiting |
Continuous Regional Analysis Device for Neonate Lung |
- Infant Respiratory Distress Syndrome
- Acute Bronchiolitis
- Acute Respiratory Distress Syndrome
|
|
Observational |
|
- University of Schleswig-Holstein
- Middlesex University London
- University College, London
- (and 8 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in aggregate measure of ventilation homogeneity (coefficient of variation and global inhomogeneity index of regional tidal volume) by > 10% compared with baseline
- Change in right-to-left and/or anteroposterior ventilation distribution by >10% compared with baseline
- Time and duration of right-to-left or left-to-right ventilation ratio >2:1
- (and 13 more...)
|
200 |
All |
up to 7 Years (Child) |
NCT02962505 |
668259 |
CRADL |
November 2016 |
December 2018 |
December 2019 |
November 11, 2016 |
February 14, 2018 |
|
- Archbishop Makarios III Hospital
Nicosia, Cyprus - Oulu University Hospital
Oulu, Finland - Papageorgiou Hospital
Thessaloníki, Greece - (and 2 more...)
|
| 43 |
NCT02657837 |
Recruiting |
Measures of Respiratory Health (MRH) |
- Cystic Fibrosis
- Asthma
- Sickle Cell Anemia
- Bronchiolitis Obliterans
|
|
Observational |
|
- The Hospital for Sick Children
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of patients with an abnormal Lung Clearance Index (>7.5).
- . Proportion of patients with an abnormal pulmonary function tests based on spirometry.
|
300 |
All |
30 Months to 30 Years (Child, Adult) |
NCT02657837 |
1000051399 |
MRH |
January 2016 |
December 2018 |
December 2018 |
January 18, 2016 |
October 14, 2016 |
|
- The Hospital for Sick Children
Toronto, Ontario, Canada
|
| 44 |
NCT02858531 |
Recruiting |
Predictive Tracking of Patient Flow in the Emergency Services During the Virus Winter Epidemics |
- Disease Outbreaks
- Child
- Elderly
- (and 2 more...)
|
|
Observational |
|
- Centre Hospitalier Universitaire de Saint Etienne
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- build a predictive tool
- Difference between the estimated date and the effective date of the activity peak on the average length of stay of patients in the hospital of Saint Etienne
- Difference between the estimated date and the effective date of the activity peak on the average length of stay of patients in the other hospitals
- (and 2 more...)
|
760000 |
All |
1 Month and older (Child, Adult, Senior) |
NCT02858531 |
1508191
1969303 v 0 |
PREDAFLU |
September 2016 |
October 2019 |
October 2019 |
August 8, 2016 |
June 27, 2017 |
|
- CHU de Grenoble (adult emergency service)
Grenoble, France - CHU de Grenoble (pediatric service)
Grenoble, France - CHU de Lyon (adult emergency service)
Lyon, France - (and 8 more...)
|
| 45 |
NCT03199976 |
Recruiting |
Efficacy of Intermittent Tiotropium in Early Childhood Wheezing |
- Wheezy Bronchitis
- Asthmatic Bronchitis
- Wheezing
- Obstruction Airway
|
- Drug: Tiotropium Bromide
- Drug: Fluticasone Propionate
- Drug: Salbutamol
|
Interventional |
Phase 4 |
- Helsinki University Central Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Episode-free days
- Unscheduled physician visits
- Rescue medication
- Adverse events
|
195 |
All |
6 Months to 35 Months (Child) |
NCT03199976 |
TFS01
2015-002985-22 |
|
April 20, 2016 |
December 31, 2020 |
December 31, 2022 |
June 27, 2017 |
June 27, 2017 |
|
- Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland
Helsinki, Finland
|
| 46 |
NCT02032381 |
Recruiting |
Prospective Study of Belated Pulmonary Complications Occurring in Children Treated With Allogeneic Hematopoietic Stem Cells. |
- Bone Marrow Transplant Infection
- Bronchiolitis Obliterans
- Chronic Respiratory Insufficiency
- (and 2 more...)
|
- Other: late pulmonary complications occurring in children treated with allogeneic hematopoietic stem cells.
|
Interventional |
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Presence of belated non-infectious pulmonary complications
- Presence of risk factors for belated non-infectious pulmonary complications
- Survival three years
- Severity of respiratory disease
|
500 |
All |
up to 18 Years (Child, Adult) |
NCT02032381 |
P120137
2013-A00966-39 |
RESPPEDHEM |
January 2014 |
January 2019 |
January 2019 |
January 10, 2014 |
October 12, 2016 |
|
- Houdouin véronique
Paris, France
|
| 47 |
NCT03392363 |
Recruiting |
Diagnosing Respiratory Disease in Children Using Cough Sounds 2 |
- Pneumonia
- Bronchiolitis
- Asthma Exacerbation
- (and 5 more...)
|
- Device: Recordings of Infants and Children's Cough Sounds
|
Observational |
|
- ResApp Health Limited
- Massachusetts General Hospital
- The Cleveland Clinic
- (and 2 more...)
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Diagnosis of pneumonia
- Diagnosis of other childhood respiratory diseases
|
1667 |
All |
up to 12 Years (Child) |
NCT03392363 |
17001 |
SMARTCOUGH-C-2 |
January 5, 2018 |
May 2018 |
June 2018 |
January 5, 2018 |
January 25, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Cleveland Clinic Children's
Cleveland, Ohio, United States - Texas Children's Hospital
Houston, Texas, United States
|
| 48 |
NCT03499938 |
Not yet recruiting
New |
Structured Light Plethysmography in Obstructive Airways Disease |
- Pediatric Respiratory Diseases
|
- Device: Structured Light Plethysmography
|
Observational |
|
- Guy's and St Thomas' NHS Foundation Trust
- Pneumacare Ltd
- University of Cambridge
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Clinical severity of breathing distress measured by modified pulmonary index score (mPIS)
- Regional SLP tidal breathing parameters (relative contribution)
- Regional SLP tidal breathing parameters (phase)
|
60 |
All |
1 Month to 12 Years (Child) |
NCT03499938 |
237151 |
|
May 2018 |
February 2019 |
February 2019 |
April 17, 2018 |
April 17, 2018 |
|
- Evelina London Children´s Hospital
London, United Kingdom
|
| 49 |
NCT02631720 |
Recruiting |
CLAD Phenotype Specific Risk Factors and Mechanisms |
- Lung Transplant
- Post Lung Transplantation
|
- Procedure: Blood Draw
- Procedure: Bronchoscopy
|
Observational |
|
- National Institute of Allergy and Infectious Diseases (NIAID)
- Clinical Trials in Organ Transplantation
|
NIH / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Time from transplant to Restrictive Chronic Lung Allograft Dysfunction (RCLAD) or Bronchiolitis Obliterans Syndrome (BOS).
- Chemokine/cytokine Quantification of Type 1 and Type 17 immune profile proteins
- Longitudinal Quality of life (QOL) trajectory
- (and 3 more...)
|
800 |
All |
18 Years and older (Adult, Senior) |
NCT02631720 |
DAIT CTOT-20 |
|
December 2015 |
October 2020 |
October 2020 |
December 16, 2015 |
December 26, 2017 |
|
- University of California, Los Angeles
Los Angeles, California, United States - Johns Hopkins University
Baltimore, Maryland, United States - Duke University
Durham, North Carolina, United States - (and 2 more...)
|
| 50 |
NCT02936505 |
Recruiting |
Clinical Study Evaluating Two Treatment Protocols for Immunosuppressive Drugs. Looking at 3-year Incidence of CLAD. |
- Lung Transplantation
- Allografts
|
- Drug: Cyclosporine
- Drug: Mycophenolate mofetil (MMF)
- Drug: Rabbit Anti thymocyte globulin
- (and 2 more...)
|
Interventional |
Not Applicable |
- Vastra Gotaland Region
- Oslo University Hospital
- Helsinki University Central Hospital
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of patients with incidence of CLAD
- Glomerular Filtration Rate
- Primary graft dysfunction
- (and 21 more...)
|
242 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02936505 |
Version 3.0
154-16
2015-004137-27 |
ScanCLAD |
October 2016 |
October 2021 |
December 2022 |
October 18, 2016 |
November 29, 2017 |
|
- Rigshospitalet
Copenhagen, Denmark - Helsinki University Hospital
Helsinki, Finland - Oslo University Hospital
Oslo, Norway - (and 2 more...)
|
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