| 1 |
NCT03443531 |
Not yet recruiting |
Effects of Traditional Chinese Medicine on Bronchiectasis Patients |
|
- Drug: Bufei Huatan granule
- Drug: Yifei Qinghua granule
- Drug: Placebo Bufei Huatan granule
- Drug: Placebo Yifei Qinghua granule
|
Interventional |
Phase 3 |
- Henan University of Traditional Chinese Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The frequency of bronchiectasis exacerbation
- The time to the first bronchiectasis exacerbation
- Changes in Forced expiratory volume in one second
|
216 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03443531 |
TCM for Bronchiectasis |
|
March 2018 |
September 2020 |
December 2020 |
February 23, 2018 |
February 23, 2018 |
|
|
| 2 |
NCT02550821 |
Recruiting |
Comparison of Physical Activity Level Between Patients With Bronchiectasis and Healthy Subjects |
|
- Device: Triaxial accelerometer
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
|
- Number of steps on accelerometer
- Energy expenditure on activity monitor
- Exercise capacity using 6-minute walk test and incremental shuttle walk test
- (and 4 more...)
|
70 |
All |
18 Years to 65 Years (Adult) |
NCT02550821 |
GO 15/313 |
|
September 2015 |
August 2016 |
August 2016 |
September 16, 2015 |
August 16, 2016 |
|
- Aslihan Cakmak
Ankara, Turkey
|
| 3 |
NCT02163642 |
Recruiting |
Role of Innate Immunity in Non-Cystic Fibrosis Bronchiectasis |
|
|
Observational |
|
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- Sociedad Española de Neumología y Cirugía Torácica
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change from baseline in sputum mucin levels at 12 months
- Change from baseline in sputum mucin levels at 3 months
- Change from baseline in sputum mucin levels at 6 months
- Change from baseline in sputum mucin levels at 9 months
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT02163642 |
IIBSP-BRO-2013-154 |
|
April 2014 |
April 2018 |
April 2018 |
June 13, 2014 |
September 8, 2016 |
|
- Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
|
| 4 |
NCT03262064 |
Not yet recruiting |
Different Phenotypes of Bronchiectasis |
|
- Combination Product: Pulmonary function tests,Bronchiectasis severity index score
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- ( Severity of Bronchiectasis will be measured according to BSI scoring system and FACED scoring system
- management of bronchectasis according to severity index
|
100 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03262064 |
DPOB |
|
October 1, 2017 |
September 1, 2018 |
March 2020 |
August 25, 2017 |
September 12, 2017 |
|
- Assiut University Hospital
Assiut, Egypt
|
| 5 |
NCT02823587 |
Recruiting |
Pulmonary Rehabilitation in Non-Cystic Fibrosis Bronchiectasis |
|
- Other: Pulmonary Rehabilitation
- Other: Control
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Mucociliary transport in vivo
- Mucociliary transport in vitro
- Quality of Life in Bronchiectasis
- (and 13 more...)
|
60 |
All |
18 Years to 60 Years (Adult) |
NCT02823587 |
USP 2016-1 |
|
July 2016 |
July 2018 |
December 2019 |
July 6, 2016 |
August 21, 2017 |
|
- Ribeirão Preto Medical School
Ribeirão Preto, São Paulo, Brazil
|
| 6 |
NCT02731482 |
Recruiting |
Short-and Long-term Effects of a Home-based Rehabilitation Program in Patients With Bronchiectasis |
|
- Other: Training Group
- Other: Control Group
|
Interventional |
Not Applicable |
- University of Nove de Julho
- University of Sao Paulo
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Distance, in meters, performed in the Incremental Shuttle Walk Test
- Time, in seconds, performed in the Endurance Shuttle Walk Test
- Number of steps performed in the Incremental Step Test
- (and 3 more...)
|
48 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02731482 |
Bronchiectasis Rehabilitation |
|
June 2016 |
December 2019 |
December 2019 |
April 7, 2016 |
March 21, 2017 |
|
- Universidade Nove de Julho
São Paulo, Brazil
|
| 7 |
NCT02179983 |
Recruiting |
Tayside Rehabilitation in Bronchiectasis Exacerbations (TRIBE) : a Randomized Controlled Trial |
|
- Procedure: Pulmonary rehabilitation
|
Interventional |
Not Applicable |
- Dr James D Chalmers
- NHS Tayside
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- 6 minute walk distance
- Time to next exacerbation
- Quality of life
- (and 3 more...)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02179983 |
NHSTayside |
TRIBE |
June 2014 |
December 2018 |
December 2018 |
July 2, 2014 |
March 20, 2018 |
|
- Clinical Research Centre, University of Dundee
Dundee, United Kingdom
|
| 8 |
NCT02625246 |
Recruiting |
Safety and Potential Efficacy of Human Mesenchymal Stem Cells in Non‐Cystic Fibrosis Bronchiectasis |
|
|
Interventional |
Phase 1 |
- Marilyn Glassberg
- University of Miami
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Participant with treatment emergent serious adverse events
- Difference in Colony Forming Units (CFUs) in semiquantitative culture of sputum
- rate of decline of lung function
- (and 3 more...)
|
6 |
All |
30 Years to 87 Years (Adult, Senior) |
NCT02625246 |
20150627 |
CELEB |
December 2015 |
June 2018 |
December 2020 |
December 9, 2015 |
December 7, 2017 |
|
- University of Miami Hospitals & Clinics
Miami, Florida, United States
|
| 9 |
NCT02804971 |
Recruiting |
Cardiovascular Comorbidities and Bronchiectasis |
|
|
Observational |
|
- Centre Hospitalier Intercommunal Creteil
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Frequency of the cardiovascular comorbidities
- Frequency of aging-related abnormalities (higher aortic pulse-wave velocity, lower bone mineral density, lower squelettal muscle mass index) and shorter telomere length in patients.
- Correlation between the severity of the disease (BSI score) and cardiovascular comorbidities.
- Correlation between biological markers of aging and inflammation.
|
200 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT02804971 |
BRONCOCA |
BRONCOCA |
September 2016 |
November 2019 |
May 2020 |
June 17, 2016 |
August 1, 2017 |
|
- Chi Creteil
Créteil, France
|
| 10 |
NCT01761214 |
Recruiting |
Bacteriology and Inflammation in Bronchiectasis |
|
- Drug: Fluroquinolones
- Drug: Beta-lactamase inhibitor
|
Interventional |
Not Applicable |
- Guangzhou Institute of Respiratory Disease
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Sputum microbiology
- Sputum sol phase inflammatory indices
- 24-hour sputum volume
- (and 6 more...)
|
80 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01761214 |
SKLRD-2013-GWJ |
BISER |
September 2012 |
December 2017 |
December 2017 |
January 4, 2013 |
August 10, 2016 |
|
- State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical College
Guangzhou, Guangdong, China
|
| 11 |
NCT02047773 |
Recruiting |
Bacterial Load Guided Therapy for Severe Bronchiectasis Exacerbations |
|
- Other: Duration
- Drug: Colomycin
- Drug: Meropenem
|
Interventional |
Phase 4 |
- University of Edinburgh
- NHS Lothian
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to next exacerbation
- Proportion of patients that stopped antibiotics early
- Clinical recovery at days 14 and 21
- (and 2 more...)
|
90 |
All |
18 Years and older (Adult, Senior) |
NCT02047773 |
BLTBrIVStudy |
BLTBrIV |
January 2014 |
November 2018 |
November 2018 |
January 28, 2014 |
July 21, 2017 |
|
- Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
|
| 12 |
NCT02564731 |
Recruiting |
Prognosis of Bronchiectasis in Children--A Multicenter Prospective Cohort Study |
|
|
Observational |
|
- Baoping XU
- Wuhan women and children's health care center
- Children's Hospital of Chongqing Medical University
- (and 12 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change from baseline in lung function on the spirometry
|
300 |
All |
up to 18 Years (Child, Adult) |
NCT02564731 |
BCHlung003 |
|
June 2016 |
March 2022 |
March 2022 |
October 1, 2015 |
January 9, 2017 |
|
- Beijing Children'S Hospital
Beijing, Beijing, China
|
| 13 |
NCT03013452 |
Recruiting |
Oscillating PEP vs Autogenic Drainage in People With Bronchiectasis |
|
- Device: oPEP
- Behavioral: Autogenic drainage
|
Interventional |
Not Applicable |
- Carmel Medical Center
- Rambam Health Care Campus
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in LCI
- Total score on QOL- B questionnaire
- Score on respiratory domain of QOL-B questionnaire
- (and 2 more...)
|
50 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03013452 |
CMC-16-0087-CTIL |
oPEP-vs-AD |
March 9, 2017 |
October 30, 2018 |
December 31, 2018 |
January 6, 2017 |
July 21, 2017 |
|
- Carmel Medical Center
Haifa, Israel - Pulmonology Institute, Carmel Medical Center
Haifa, Israel
|
| 14 |
NCT02555865 |
Recruiting |
Aetiology of Children With Bronchiectasis in China |
|
|
Observational |
|
- Beijing Children's Hospital
- Wuhan women and children's health care center
- Children's Hospital of Chongqing Medical University
- (and 10 more...)
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Number of participants with differential causes of bronchiectasis by reviewing the medical records or undergoing the standard diagnostic process
|
300 |
All |
up to 18 Years (Child, Adult) |
NCT02555865 |
BCHlung002 |
|
June 2016 |
March 2022 |
March 2022 |
September 22, 2015 |
January 9, 2017 |
|
- Beijing Children'S Hospital
Beijing, Beijing, China
|
| 15 |
NCT02574143 |
Recruiting |
The PROspective German NOn-CF bronchiectaSIS Patient Registry |
|
|
Observational |
|
- Hannover Medical School
- CAPNETZ Stiftung
- German Center for Lung Research
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Number of participants with non-CF bronchiectasis (NCFB) across all different levels of health care regarding the current management of NCFB in Germany
- Prevalence of non-CF bronchiectasis (NCFB) etiologies (composite outcome measures) across all different levels of health care
|
750 |
All |
18 Years and older (Adult, Senior) |
NCT02574143 |
PROGNOSIS |
PROGNOSIS |
July 2015 |
June 2018 |
July 2018 |
October 12, 2015 |
May 3, 2016 |
|
- Helios Klinikum Emil von Behring - Lungenklinik Heckeshorn
Berlin, Germany - Augusta-Kranken-Anstalt Bochum -Klinik für Pneumologie, Beatmungsmedizin und Infektiologie
Bochum, Germany - Fachkrankenhaus Coswig
Coswig, Germany - (and 16 more...)
|
| 16 |
NCT02722642 |
Recruiting |
Autologous Bronchial Basal Cells Transplantation for Treatment of Bronchiectasis |
|
- Biological: Bronchial basal cells
|
Interventional |
Phase 1
Phase 2 |
- Regend Therapeutics
- Southwest Hospital, China
- Tongji University
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- CT imaging of dilated bronchi
- 6-minute walk distance test
- MRC chronic dyspnea scale
- (and 14 more...)
|
20 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02722642 |
201602301 |
|
March 2016 |
January 2019 |
January 2019 |
March 30, 2016 |
October 28, 2016 |
|
- First Affiliated Hospital of the Third Military University, PLA (Southwest Hospital)
Chongqing, Chongqing, China
|
| 17 |
NCT02468271 |
Recruiting |
Clinimetric Properties of Outcome Measures in Bronchiectasis in the UK |
|
|
Observational |
|
- Queen's University, Belfast
- Belfast Health and Social Care Trust
- South Eastern Health and Social Care Trust
- (and 7 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Lung clearance index
- Spirometry
- St Georges Respiratory Questionnaire (SGRQ)
- (and 4 more...)
|
100 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT02468271 |
MR/L011263/1 |
|
October 2015 |
May 31, 2018 |
July 31, 2019 |
June 10, 2015 |
April 25, 2018 |
|
- Papworth Hospital, NHS Foundation Trust
Cambridge, England, United Kingdom - Royal Brompton and Harefield Trust
London, England, United Kingdom - University Hospital Southampton, NHS Foundation Trust
Southampton, England, United Kingdom - (and 4 more...)
|
| 18 |
NCT02509091 |
Recruiting |
Therapy of Bronchoalveolar Lavage and Local Amikacin Injection in Patients With Acute Exacerbation of Bronchiectasis |
|
- Drug: Bronchoalveolar Lavage and Local Amikacin Injection
|
Interventional |
Phase 4 |
- Shanghai Pulmonary Hospital, Shanghai, China
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement of Sputum volume and properties
- changes in lung function (including Forced expiratory volume in one second (FEV1) ,forced vital capacity(FVC) and forced vital capacity rate of one second(FEV1/FVC))
- Dyspnea score according by Modified Medical Research Center(MMRC)
- (and 2 more...)
|
100 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02509091 |
20150616 |
|
December 2014 |
June 2016 |
December 2016 |
July 27, 2015 |
May 16, 2016 |
|
- Shanghai Pulmonary Hospital
Shanghai, Shanghai, China
|
| 19 |
NCT03147651 |
Recruiting |
Exercise Capacity in Patients With Cystic Fibrosis vs. Non-cystic Fibrosis Bronchiectasis |
|
|
Observational |
|
- Rambam Health Care Campus
|
Other |
- Observational Model: Cohort
- Time Perspective: Other
|
- Oxygen Uptake (VO2)
- Spirometry
- Oxygen saturation
- (and 2 more...)
|
119 |
All |
7 Years and older (Child, Adult, Senior) |
NCT03147651 |
0048-15-RMB-CTIL |
|
October 2015 |
September 2017 |
December 2017 |
May 10, 2017 |
May 10, 2017 |
|
- RAMBAM Health Care Campus
Haifa, Israel
|
| 20 |
NCT02657473 |
Recruiting |
Inhaled Nebulized Tobramycin in Non-cystic Fibrosis Bronchiectasis |
|
- Drug: tobramycin inhalation solution
- Drug: Saline 0.9% inhalation solution
|
Interventional |
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
|
52 |
All |
18 Years and older (Adult, Senior) |
NCT02657473 |
54939 |
BATTLE |
August 2016 |
August 2021 |
August 2021 |
January 15, 2016 |
September 8, 2017 |
|
- North West Clinics
Alkmaar, Noord-Holland, Netherlands
|
| 21 |
NCT03218917 |
Recruiting |
Assessment of INS1007 in Subjects With Non-Cystic Fibrosis Bronchiectasis |
- Non-Cystic Fibrosis Bronchiectasis
|
- Drug: INS1007 10 mg oral tablet
- Drug: INS1007 25 mg oral tablet
- Drug: Placebo Oral Tablet
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time to first pulmonary exacerbation
- Rate of pulmonary exacerbations
- Change from Baseline in the Respiratory Symptoms Domain Score of the Quality of Life (QOL) Bronchiectasis questionnaire
- (and 2 more...)
|
240 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT03218917 |
INS1007-201
2017-002533-32 |
|
December 1, 2017 |
June 2020 |
June 2020 |
July 17, 2017 |
February 6, 2018 |
|
- NewportNativeMD
Newport Beach, California, United States
|
| 22 |
NCT03428334 |
Recruiting |
Roflumilast in Non-CF Bronchiectasis Study |
- Non-cystic Fibrosis Bronchiectasis
|
|
Interventional |
Phase 2 |
- The University of Hong Kong
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT03428334 |
ROF2017_v1 |
|
February 2018 |
August 31, 2019 |
August 31, 2019 |
February 9, 2018 |
February 9, 2018 |
|
- Queen Mary Hospital
Hong Kong, Hong Kong
|
| 23 |
NCT03460704 |
Recruiting |
Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium (PROMIS-2) |
- Non Cystic Fibrosis Bronchiectasis
|
- Drug: Colistimethate sodium
- Drug: Saline Solution
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Annualized Pulmonary Exacerbation rate
- Annualised number of pulmonary exacerbation-free days
- Time to first pulmonary exacerbation
- (and 6 more...)
|
374 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT03460704 |
Z7224L02 |
|
January 29, 2018 |
March 2021 |
March 2021 |
March 9, 2018 |
April 5, 2018 |
|
- EMED Centrum Usług Medycznych
Rzeszów, Poland
|
| 24 |
NCT02712983 |
Recruiting |
Dose-finding Study to Assess the Efficacy, Safety and Tolerability of Tobramycin Inhalation Powder in Patients With Non-Cystic Fibrosis Bronchiectasis and Pulmonary P. Aeruginosa Infection |
- Non-cystic Fibrosis Bronchiectasis
|
- Drug: TIP
- Drug: TIP and placebo
- Drug: Placebo
|
Interventional |
Phase 2 |
- Novartis Pharmaceuticals
- Queen's University Belfast, UK
- University Hospital Antwerp, BE
- (and 8 more...)
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- P. aeruginosa density in sputum
- Frequency of pulmonary exacerbations
- Time to first use of antipseudomonal antibiotics
- (and 9 more...)
|
180 |
All |
18 Years and older (Adult, Senior) |
NCT02712983 |
CTBM100G2202 |
iBEST-1 |
February 8, 2017 |
January 17, 2019 |
January 17, 2019 |
March 18, 2016 |
March 21, 2018 |
|
- Novartis Investigative Site
Bruxelles, Belgium - Novartis Investigative Site
Leuven, Belgium - Novartis Investigative Site
Bayonne, Bayonne Cedex, France - (and 44 more...)
|
| 25 |
NCT03093974 |
Recruiting |
Trial in Non-cystic Fibrosis Bronchiectasis Patients With Chronic Lung Infections Treated With Colistimethate Sodium |
- Non Cystic Fibrosis Bronchiectasis
|
- Drug: Colistimethate Sodium
- Drug: Saline Solution
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Time to first pulmonary exacerbation
- Exacerbation rate
- Quality of life (SGRQ)
- (and 2 more...)
|
264 |
All |
18 Years and older (Adult, Senior) |
NCT03093974 |
Z7224L01 |
PROMIS-I |
June 1, 2017 |
April 2019 |
April 2019 |
March 28, 2017 |
January 10, 2018 |
|
- Hôpital Erasme
Bruxelles, Belgium - Az Delta Pneumology
Roeselare, Belgium - Pneumologische Praxis am Schloss Charlottenburg
Berlin, Germany - (and 38 more...)
|
| 26 |
NCT03376204 |
Recruiting |
Pain Mechanisms in Patients With Bronchiectasis |
- Bronchiectasis
- Respiratory Disease
|
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Referred pain area
- Number of body areas affected by referred pain
- Pain intensity after supra threshold pain stimulus (STPS)
- (and 17 more...)
|
44 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT03376204 |
PI17/0290 |
|
September 29, 2017 |
October 31, 2019 |
November 30, 2019 |
December 18, 2017 |
December 18, 2017 |
|
- Universidad San Jorge
Villanueva de Gállego, Zaragoza, Spain
|
| 27 |
NCT02315547 |
Recruiting |
Sputum Microbiota and the Association With Clinical Parameters in Steady-state, Acute Exacerbation and Convalescence of Bronchiectasis |
|
|
Interventional |
Not Applicable |
- Guangzhou Institute of Respiratory Disease
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- relative abundance, diversity and richness of microbiota taxa
- Serum inflammatory indices
- Sputum sol phase inflammatory biomarkers
- (and 8 more...)
|
120 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02315547 |
GIRD-20141208-GWJ |
BISER-2 |
January 2015 |
November 2017 |
December 2017 |
December 12, 2014 |
August 10, 2016 |
|
- Guangzhou Institute of Respiratory Disease
Guangzhou, Guangdong, China
|
| 28 |
NCT02765295 |
Recruiting |
Efficacy and Safety of Hydrogen Inhalation on Bronchiectasis: A Randomized, Multi-center, Double-blind Study |
- Bronchiectasis
- Acute Exacerbation of Bronchiectasis
- Oxidative Stress
|
- Device: medical ultrasonic hydrogen/oxygen nebulizer (MUNHO)
- Device: Medical molecular mesh oxygen generator
|
Interventional |
Not Applicable |
- Guangzhou Institute of Respiratory Disease
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Frequency of bronchiectasis exacerbations (BEs) within 12 months
- Changes in sputum oxidant (hydrogen peroxide, reactive oxygen species) levels at month 6 and 12 as compared with baseline
- Time to the first bronchiectasis exacerbations (BEs) within 12 months
- (and 6 more...)
|
120 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02765295 |
GWJ-2015-H2 |
HYBRID |
June 1, 2016 |
December 2018 |
December 2018 |
May 6, 2016 |
December 4, 2017 |
|
- First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China - The Second Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China - West China Hospital Affiliateyd to Sichuan Universit
Chengdu, China - (and 2 more...)
|
| 29 |
NCT02779478 |
Recruiting |
Evaluation Of The Lung Microbiome In NTM Bronchiectasis |
- Nontuberculous Mycobacteria
- Bronchiectasis
|
|
Observational |
|
- New York University School of Medicine
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Evaluation of airway microbiome in subjects with active pulmonary NTM disease and compare with controls
- Eating Assessment Tool (EAT-10) to evaluate the prevalence of laryngopharyngeal reflux and dysphagia/aspiration in subjects with active pulmonary NTM disease compared with controls
- Laryngoscopy to calculate the Reflux finding score (RFS, a validated quantitative measurement of impact of laryngopharyngeal reflux on the upper airway in adults
- Reflux Symptom Index evaluate the prevalence of laryngopharyngeal reflux and dysphagia/aspiration in subjects with active pulmonary NTM disease compared with controls
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT02779478 |
14-01400 |
|
April 2016 |
August 2018 |
August 2018 |
May 20, 2016 |
November 22, 2017 |
|
- New York University School of Medicine
New York, New York, United States
|
| 30 |
NCT02514226 |
Recruiting |
Evaluation of Periodontal Treatment in Patients With Bronchiectasis |
- Bronchiectasis
- Periodontal Disease
|
- Procedure: supragingival treatment
- Procedure: periodontal treatment
- Procedure: periodontal treatment and photodynamic therapy
- Other: dental hygiene orientation
|
Interventional |
Not Applicable |
- University of Nove de Julho
- InCor Heart Institute
- University of Sao Paulo
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP #2015/20535-1)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Microbiological evaluation
- Halitosis measurements
|
90 |
All |
35 Years and older (Adult, Senior) |
NCT02514226 |
44769315.0.0000.5511 |
|
August 2015 |
December 2017 |
October 2018 |
August 3, 2015 |
February 28, 2017 |
|
- InCor Heart Institute
Sao Paulo, São Paulo, Brazil
|
| 31 |
NCT01270074 |
Recruiting |
Prevention of Bronchiectasis in Infants With Cystic Fibrosis |
- Cystic Fibrosis
- Bronchiectasis
|
- Drug: Azithromycin
- Drug: Placebo control
|
Interventional |
Phase 3 |
- Queensland Children's Medical Research Institute
- Telethon Kids Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Proportion of children with radiologically-defined bronchiectasis
- extent and severity of bronchiectasis
- CF-related quality of life
- (and 7 more...)
|
130 |
All |
6 Weeks to 6 Months (Child) |
NCT01270074 |
AZI001
STICK10K0 |
COMBATCF |
April 2012 |
May 2020 |
December 2020 |
January 5, 2011 |
April 29, 2016 |
|
- Sydney Children's Hospital
Sydney, New South Wales, Australia - Westmead Children's Hospital
Sydney, New South Wales, Australia - Mater Children's Hospital
Brisbane, Queensland, Australia - (and 7 more...)
|
| 32 |
NCT03467035 |
Recruiting |
Role of NLRP3 Inflammasone and Hypoxia in the Severity of Osteoporosis in Patients With Bronchiectasis |
- Bronchiectasis Adult
- Osteoporosis, Osteopenia
|
|
Observational |
|
- Chun-Hua Wang, MD
- Chang Gung Memorial Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
80 |
All |
20 Years and older (Adult, Senior) |
NCT03467035 |
201701317A3 |
|
December 21, 2017 |
December 31, 2018 |
June 30, 2019 |
March 15, 2018 |
March 15, 2018 |
|
- Chang Gung Memorial Hospital
Taipei, Taiwan
|
| 33 |
NCT03177889 |
Not yet recruiting |
Lung Dispersing, Turbid Descending and Gut Clearing Decoction for Bronchiectasis |
- Bronchiectasis Adult
- Traditional Chinese Medicine
- Quality of Life
- Exacerbation
|
- Combination Product: Traditional Chinese Medicine (TCM)
|
Interventional |
Not Applicable |
- Guangzhou Institute of Respiratory Disease
- Guangdong Provincial Hospital of Traditional Chinese Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in Bronchiectasis Health Questionnaire scores at month 6 compared with baseline
- the frequency of bronchiectasis exacerbation
- the time to the first bronchiectasis exacerbation
- (and 4 more...)
|
80 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03177889 |
GWJ-TCM-2017 |
LUNG-CLEAR |
July 31, 2018 |
August 31, 2019 |
December 31, 2019 |
June 6, 2017 |
June 7, 2017 |
|
|
| 34 |
NCT01822834 |
Recruiting |
Bronchiectasis Research Registry |
- Non-CF Bronchiectasis
- Nontuberculosis Mycobacteria (NTM)
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Patient Recruitment and Data analysis
|
5000 |
All |
18 Years to 120 Years (Adult, Senior) |
NCT01822834 |
BRR |
|
January 2008 |
December 2050 |
|
April 2, 2013 |
July 26, 2016 |
|
- COPD Foundation
Washington, District of Columbia, United States
|
| 35 |
NCT00943514 |
Recruiting |
Natural History of Bronchiectasis |
- Bronchiectasis
- Cystic Fibrosis
- Autoimmune Disease
- Common Variable Immunodeficiency
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Document the presence of underlying associated conditions such as: Variant cystic fibrosis, Primary ciliary dyskinesia, Common variable immunodeficiency, Allergic bronchopulmonary mycosis, Autoimmune dx, Autoimmune dx, alpha-1 antitrypsin defici...
- Assessment of genetic, systemic immune, and/or epithelial surface defense mechanisms involved in airway infection susceptibility and/or in the development of bronchiectasis through the:a)Collection and storage of blood and sputumb)Use and ...
|
900 |
All |
5 Years and older (Child, Adult, Senior) |
NCT00943514 |
090172
09-H-0172 |
|
July 20, 2009 |
|
|
July 22, 2009 |
April 25, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 36 |
NCT02279329 |
Recruiting |
Longitudinal Study of Helium-3 and Xenon-129 Magnetic Resonance Imaging |
|
- Other: Hyperpolarized Helium MRI
|
Interventional |
Not Applicable |
- Dr. Grace Parraga
- London Health Sciences Centre
- Western University, Canada
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Ventilation Defect Percent (VDP)
- Apparent Diffusion Coefficients (ADC)
- Six Minute Walk Distance (6MWD)
- (and 2 more...)
|
200 |
All |
50 Years to 85 Years (Adult, Senior) |
NCT02279329 |
ROB0018 |
|
May 2009 |
March 2018 |
March 2018 |
October 31, 2014 |
May 9, 2017 |
|
- Robarts Research Insitute; The University of Western Ontario; London Health Sciences Centre
London, Ontario, Canada
|
| 37 |
NCT02906826 |
Recruiting |
Adherence to Airway Clearance. Novel Approaches to Improving Adherence |
- Cystic Fibrosis
- Bronchiectasis
|
|
Interventional |
Not Applicable |
- University of British Columbia
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
|
- Adherence to therapy
- Pulmonary function
|
20 |
All |
6 Years to 12 Years (Child) |
NCT02906826 |
UBColumbia |
|
August 2016 |
May 2017 |
September 2017 |
September 20, 2016 |
September 20, 2016 |
|
- University of British Columbia
Vancouver, British Columbia, Canada
|
| 38 |
NCT03147443 |
Recruiting |
Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials |
- Bronchiectasis
- Quality of Life
- Traditional Chinese Medicine
- (and 3 more...)
|
- Drug: Individualized Decoction
- Drug: placebo
- Drug: Tested drug minus heat-clearing herbs
|
Interventional |
Phase 4 |
- Shanghai University of Traditional Chinese Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Patient Self-Rated Symptom Score
- 24 h Sputum Volume
|
36 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03147443 |
haiyinhuang |
|
March 1, 2017 |
November 1, 2018 |
December 31, 2019 |
May 10, 2017 |
May 10, 2017 |
|
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine
Shanghai, Shanghai, China
|
| 39 |
NCT03153800 |
Recruiting |
Autologous Bronchial Basal Cells Transplantation for Treatment of CRD Including COPD, BE and PF |
- Chronic Respiratory Disease
|
- Biological: bronchial basal cells
|
Interventional |
Early Phase 1 |
- Regend Therapeutics
- The First Affiliated Hospital of Soochow University
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Forced expiratory volume in one second (FEV1)
- Diffusion capacity of CO (DLCO)
- The ratio of forced expiratory volume in the first one second to the forced vital capacity (FEV1/FVC)
- (and 7 more...)
|
30 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03153800 |
2017042 |
|
April 5, 2017 |
April 4, 2019 |
October 4, 2019 |
May 15, 2017 |
May 15, 2017 |
|
- The First Affiliated Hopsital of Soochow University
Suzhou, Jiang Su, China
|
| 40 |
NCT02527486 |
Recruiting |
Seoul National University Airway Registry |
- Chronic Obstructive Pulmonary Disease (COPD)
- Asthma
- Asthma With Chronic Obstructive Pulmonary Disease
- (and 3 more...)
|
|
Observational |
|
- Seoul National University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Death (time to death)
- post-bronchodilator FEV1 change rates
|
800 |
All |
20 Years to 90 Years (Adult, Senior) |
NCT02527486 |
AW_registry |
|
September 2011 |
December 2021 |
December 2031 |
August 19, 2015 |
August 19, 2015 |
|
- Seoul National University Bundang Hospital
Seongnam, Gyeonggi-Do, Korea, Republic of - Seoul National University Hospital
Seoul, Korea, Republic of - Seoul Metropolitan Government-Seoul National University Boramae Medical Center
Seoul, Korea, Republic of
|
| 41 |
NCT03320382 |
Recruiting |
Multiple Breath Washout, a Clinimetric Dataset |
- Cystic Fibrosis
- Primary Ciliary Dyskinesia
- Bronchiectasis
- (and 3 more...)
|
- Device: Multiple breath washout testing
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Lung Clearance Index
- Spirometry
- Disease specific Quality of life questionnaire
- Review of clinically indicated tests
|
530 |
All |
2 Years and older (Child, Adult, Senior) |
NCT03320382 |
17/NI/0046 |
|
May 5, 2017 |
March 2021 |
March 2022 |
October 25, 2017 |
October 25, 2017 |
|
- Royal Brompton Hospital
London, United Kingdom
|
| 42 |
NCT02859194 |
Recruiting |
The Effect of Lt to Rt Shunt Using Veno-veno-arterial Extracorporeal Membrane Oxygenation (ECMO) on Coronary Oxygenation in Lung Transplantation Patients |
- Interstitial Pulmonary Fibrosis ARDS
- COPD (Chronic Obstructive Pulmonary Disease)
- Bronchiectasis
- (and 3 more...)
|
- Procedure: Veno-veno-arterial ECMO
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- arterial blood oxygen partial pressure (PaO2)
- venous blood oxygen partial pressure (PvO2)
|
10 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT02859194 |
4-2016-0124 |
|
March 2016 |
December 2016 |
December 2016 |
August 8, 2016 |
August 8, 2016 |
|
- Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine
Seoul, Korea, Republic of
|
| 43 |
NCT03120481 |
Recruiting |
Controls for Respiratory Diseases |
- Chronic Obstructive Pulmonary Disease
- Asthma
- Idiopathic Pulmonary Fibrosis
- (and 3 more...)
|
|
Observational |
|
- Seoul National University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Mortality
- Hospitalization
- Respiratory hospitalization
- Respiratory diseases diagnosis
|
1572 |
All |
19 Years to 90 Years (Adult, Senior) |
NCT03120481 |
2016-3435 |
|
April 10, 2017 |
February 28, 2037 |
February 28, 2037 |
April 19, 2017 |
April 19, 2017 |
|
- Seoul National University Healthcare System Gangnam Center
Seoul, Korea, Republic of
|
| 44 |
NCT03455686 |
Not yet recruiting |
Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease |
- Asthma
- Chronic Obstructive Pulmonary Disease
- Bronchiectasis
- (and 5 more...)
|
- Other: Hyperpolarized 129Xe MRI
|
Interventional |
Not Applicable |
- McMaster University
- St. Joseph's Healthcare Hamilton
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Ventilation Defect Percent (VDP)
- Apparent Diffusion Coefficient (ADC)
- Signal-to-noise ratio (SNR)
|
60 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT03455686 |
FIRH_Xe0001 |
|
March 2018 |
March 2023 |
March 2023 |
March 6, 2018 |
March 6, 2018 |
|
- Firestone Institute for Respiratory Health, St. Joseph's Healthcare
Hamilton, Ontario, Canada
|
| 45 |
NCT02913365 |
Recruiting |
Etiologies, Investigations and Outcomes of Patients Presenting With Hemoptysis |
- Hemoptysis
- Haemoptysis
- Lung Disease
- (and 17 more...)
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Etiologies of hemoptysis
- Sensitivity of chest X-ray, chest CT-scan and CT-angiography, bronchoscopy, ventilation-perfusion with single-photon emission computed tomography and pulmonary angiography.
- All-cause mortality at 2 years
- (and 6 more...)
|
1000 |
All |
18 Years and older (Adult, Senior) |
NCT02913365 |
12-099 |
|
October 2012 |
June 2017 |
June 2017 |
September 23, 2016 |
September 23, 2016 |
|
- Centre Hospitalier Universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
|
| 46 |
NCT02748798 |
Not yet recruiting |
Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders |
- Lung Transplant
- Lung Resection
- Lung Cancer
- (and 16 more...)
|
- Drug: HP 3He
- Drug: HP 129Xe
- Drug: PFP
- (and 4 more...)
|
Interventional |
Early Phase 1 |
- Thunder Bay Regional Research Institute
- Thunder Bay Regional Health Sciences Centre
- St. Joseph's Care Group
- Lakehead University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Signal to Noise Ratio
- Correlation with PFTs
|
160 |
All |
18 Years and older (Adult, Senior) |
NCT02748798 |
RP-312-07112014 |
|
December 2017 |
July 2019 |
December 2019 |
April 22, 2016 |
October 18, 2017 |
|
- Thunder Bay Regional RI
Thunder Bay, Ontario, Canada
|
| 47 |
NCT00001223 |
Recruiting |
Studying Patients With Cystic Fibrosis and Other Pulmonary and Pancreatic Disorders |
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
99999999 |
All |
4 Years and older (Child, Adult, Senior) |
NCT00001223 |
870029
87-DK-0029 |
|
February 18, 1987 |
|
|
November 4, 1999 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 48 |
NCT02803242 |
Recruiting |
COPD Patient-Powered Research Network |
- Chronic Obstructive Pulmonary Disorder
- Chronic Obstructive Lung Disease
- Emphysema
- Chronic Bronchitis
|
- Other: Patient Reported Outcomes
|
Observational |
|
- COPD Foundation
- Kaiser Foundation Hospitals, Center for Health Research
|
Other |
- Observational Model: Cohort
|
- Patient Reported Outcome Measurement Information System-29 (PROMIS-29)
- COPD Assessment Test (CAT)
- Modified Medical Research Council (MMRC) Dyspnea Scale
- Charlson Comorbidity Index (CCI)
|
75000 |
All |
18 Years and older (Adult, Senior) |
NCT02803242 |
COPDPPRN |
COPD PPRN |
August 2014 |
January 2025 |
January 2030 |
June 16, 2016 |
June 17, 2016 |
|
- COPD Foundation
Washington, District of Columbia, United States
|
| 49 |
NCT02878447 |
Recruiting |
The Utility of Radiotherapy in the Management of Haemoptysis Secondary to Aspergillomata and Structural Lung Diseases |
|
- Radiation: External beam radiotherapy
|
Interventional |
Not Applicable |
- University of Stellenbosch
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Composite end-point of time to recurrent life-threatening haemoptysis, or death
- Six minute walk test
- Time to massive haemoptysis (>200mL per day)
- (and 5 more...)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02878447 |
M15/09/033 |
|
June 2016 |
March 2018 |
March 2019 |
August 25, 2016 |
October 26, 2017 |
|
- University of Stellenbosch
Cape Town, Western Cape, South Africa
|
| 50 |
NCT03494894 |
Recruiting
New |
Bacteriological Link Between Upper and Lower Airways in Cystic Fibrosis and Primary Ciliary Dyskinesia |
- Cystic Fibrosis
- Primary Ciliary Dyskinesia
|
- Other: Analysis with sequencing of the genotype of the bacteria
|
Interventional |
Not Applicable |
- Centre Hospitalier Intercommunal Creteil
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Presence of bacterial colonization of the upper and lower airway
- bacteriological concordance
- bacteria genotype
- bacteriological concordance in children and adult
|
120 |
All |
6 Years and older (Child, Adult, Senior) |
NCT03494894 |
BAVASI |
BAVASI |
June 1, 2017 |
June 1, 2018 |
December 2018 |
April 11, 2018 |
April 11, 2018 |
|
- Centre Hospitalier Intercommunal de Créteil
Créteil, France
|
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