| 1 |
NCT03196739 |
Recruiting |
Feasibility of Virtual Reality Games Using Head-mounted Display on Patients With Brain Disorders |
- Upper Extremity Dysfunction
- Brain Diseases
|
- Device: Virtual rehabilitation
|
Interventional |
Not Applicable |
- Seoul National University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Device Feasibility
|
- Change of Action Research Arm Test
- Change of Box and Block Test
- Change of Modified Barthel Index
- (and 3 more...)
|
12 |
All |
18 Years and older (Adult, Senior) |
NCT03196739 |
VRfeasibility1.2 |
|
June 20, 2017 |
April 30, 2018 |
May 30, 2018 |
June 23, 2017 |
March 9, 2018 |
|
- Korea Workers' Compensation & Welfare Service Incheon Hospital
Incheon, Korea, Republic of - Seoul National University Hospital
Seoul, Korea, Republic of
|
| 2 |
NCT00645645 |
Recruiting |
A Study of the Genetic Analysis of Brain Disorders |
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
6000 |
All |
Child, Adult, Senior |
NCT00645645 |
980249
98-HG-0249 |
|
October 2, 1998 |
|
|
March 28, 2008 |
April 25, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States - Baylor College of Medicine
Houston, Texas, United States - Children's Hospital of the University of Heidelberg, Germany
Heidelberg, Germany
|
| 3 |
NCT03338270 |
Recruiting |
Clinical Validation Study of Multi-EPI Mix |
|
|
Observational |
|
- Karolinska University Hospital
- GE Healthcare
|
Other / Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Diagnostic potential
- Lesion location determination
- Lesion classification
- (and 9 more...)
|
100 |
All |
Child, Adult, Senior |
NCT03338270 |
Neuroradiology Karolinska Uni. |
|
December 1, 2017 |
March 2018 |
October 2018 |
November 9, 2017 |
December 19, 2017 |
|
- Karolinska University Hospital
Stockholm, Sweden
|
| 4 |
NCT03023566 |
Recruiting |
Intra-individual Open-label, Single Center Study to Compare Unenhanced MRI With Dotarem Enhanced MRI |
|
|
Observational |
|
- Phoenix Children's Hospital
- Guerbet
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Overall lesion visualization and characterization
- Efficacy of enhanced MRI compared to unenhanced MRI
- Assessment of adverse events (AEs)
|
250 |
All |
up to 18 Years (Child, Adult) |
NCT03023566 |
PCH IRB#16-102 |
|
February 9, 2017 |
February 8, 2018 |
February 8, 2018 |
January 18, 2017 |
March 15, 2017 |
|
- Phoenix Children's Hospital
Phoenix, Arizona, United States
|
| 5 |
NCT02435810 |
Recruiting |
Inflammatory and Infectious Diseases of the Nervous System |
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- This is a natural history study of individual cases
|
500 |
All |
2 Years and older (Child, Adult, Senior) |
NCT02435810 |
150125
15-N-0125 |
|
May 1, 2015 |
November 29, 2025 |
November 29, 2060 |
May 6, 2015 |
March 21, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 6 |
NCT02889939 |
Recruiting |
High-intensity Training in an Enriched Environment in Late Phase After Stroke |
|
- Other: Training + Enriched environment
- Other: Control
|
Interventional |
Phase 2 |
- Göteborg University
- Wallström och Sjöbloms stiftelse
- Peter Erikssons minnesfond
- Back to Life
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Modified Motor Assessment Scale score according to Uppsala from baseline to after intervention/control and from baseline to 6 months follow up.
- Change in Six minute walking test from baseline to after intervention/control and from baseline to 6 months follow up.
- Change in 10 m walk test from baseline to after intervention/control and from baseline to 6 months follow up.
- (and 11 more...)
|
41 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02889939 |
EEHITStroke |
|
September 2012 |
July 2015 |
March 2017 |
September 7, 2016 |
September 7, 2016 |
|
- Sahlgrenska University Hospital
Gothenburg, Sweden
|
| 7 |
NCT03027869 |
Recruiting |
Normal Brain Imaging Database for Brain Disorder Studies |
|
- Device: transcranial direct current stimulation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- functional connectivity
- Stroop task performance
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03027869 |
B2016:074 |
Normal_tDCS |
June 28, 2017 |
December 2018 |
December 2019 |
January 23, 2017 |
July 6, 2017 |
|
- University of Manitoba
Winnipeg, Manitoba, Canada
|
| 8 |
NCT00305305 |
Recruiting |
Brain Development Research Program |
- Brain Disorders
- Aicardi Syndrome
|
|
Observational |
|
- University of California, San Francisco
- University of Washington
- California Institute of Technology
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
2000 |
All |
Child, Adult, Senior |
NCT00305305 |
UCSF-PCRC #2206 |
|
August 2003 |
January 2018 |
January 2018 |
March 21, 2006 |
January 11, 2017 |
|
- University of California, San francisco
San Francisco, California, United States
|
| 9 |
NCT00697411 |
Recruiting |
Study of Selected X-Linked Disorders: Aicardi Syndrome |
- Aicardi Syndrome
- Brain Disorders
|
|
Observational |
|
- Baylor College of Medicine
- Aicardi Syndrome Foundation
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
|
300 |
All |
Child, Adult, Senior |
NCT00697411 |
BCM Aicardi H12791 |
|
October 2002 |
January 2020 |
January 2020 |
June 13, 2008 |
January 9, 2018 |
|
- Baylor College of Medicine
Houston, Texas, United States
|
| 10 |
NCT02106065 |
Recruiting |
VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers |
- Dementia
- Caregivers
- Neurodegenerative Diseases
- Brain Diseases
|
- Behavioral: Education and Skill-Building Rehabilitation (ESBR)
- Other: Supplemental Education Materials
|
Interventional |
Phase 1 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- change in caregiver quality of life
- change in caregiver depressive symptoms
- change in community tenure (care recipient)
- (and 2 more...)
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT02106065 |
E1240-W
5IK2RX001240-02 |
VA CARES |
February 21, 2014 |
September 30, 2020 |
September 30, 2020 |
April 7, 2014 |
December 26, 2017 |
|
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
|
| 11 |
NCT03253354 |
Recruiting |
Neurostimulation for Dysphagia in Parkinson's Disease |
- Dysphagia
- Parkinson Disease
- Swallowing Disorder.Other Specified
- Brain Diseases
|
- Device: repetitive magnetic stimulation
|
Interventional |
Not Applicable |
- University of Manchester
- Salford Royal NHS Foundation Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Videofluoroscopy
- Brain excitability
|
66 |
All |
18 Years and older (Adult, Senior) |
NCT03253354 |
IRAS: 200591 |
|
August 1, 2017 |
July 31, 2018 |
December 31, 2018 |
August 17, 2017 |
August 17, 2017 |
|
- Salford Royal Hospital
Salford, Manchester, United Kingdom
|
| 12 |
NCT00237315 |
Recruiting |
Longitudinal Study of Urea Cycle Disorders |
- Brain Diseases, Metabolic, Inborn
- Amino Acid Metabolism, Inborn Errors
- Urea Cycle Disorders
|
|
Observational |
|
- Andrea Gropman
- National Center for Research Resources (NCRR)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- (and 2 more...)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Prevalence of specific morbid indicators of disease severity
- Relationship between various biomarkers and disease severity and progression
- Safety and efficacy of currently used and new UCD therapies
|
1100 |
All |
Child, Adult, Senior |
NCT00237315 |
RDCRN 5101
U54RR019453
U54HD061221 |
|
February 2006 |
July 2019 |
December 2019 |
October 12, 2005 |
November 1, 2017 |
|
- University of California, Los Angeles
Los Angeles, California, United States - University of California San Francisco
San Francisco, California, United States - Stanford University Medical Center
Stanford, California, United States - (and 13 more...)
|
| 13 |
NCT02055248 |
Recruiting |
Study on Moebius Syndrome and Congenital Facial Weakness Disorders |
- Brain Disorders
- Birth Defects
- Craniofacial Differences
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- National Eye Institute (NEI)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- (and 3 more...)
|
NIH / Other |
- Time Perspective: Retrospective
|
- Characterize the phenotype of Moebius syndrome and other congenital facial weakness disorders to determine the prevalence of associated malformations and inform subsequent genetic studies.
- Obtain imaging studies to explore cranial nerve structure and associated brain/brainstem and white matter tract anomalies and associate with the neurocognitive and behavioral phenotype of the patients.
|
700 |
All |
2 Years to 80 Years (Child, Adult, Senior) |
NCT02055248 |
140055
14-HG-0055 |
|
February 4, 2014 |
September 5, 2022 |
September 5, 2022 |
February 5, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 14 |
NCT02637817 |
Recruiting |
MRI-based Biomarkers for Predicting Punctate White Matter Lesions in Neonates |
- Brain Diseases
- Amblyopia
- Brain Damage, Chronic
- Cerebral Palsy
|
|
Observational |
|
- First Affiliated Hospital Xi'an Jiaotong University
- Shenzhen Children's Hospital
- General Hospital of Ningxia Medical University
- (and 8 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Cerebral Palsy
- Amblyopia or movement disorder
|
600 |
All |
up to 28 Days (Child) |
NCT02637817 |
2016YFC0100300 |
PWML |
January 2016 |
June 2019 |
|
December 22, 2015 |
August 10, 2016 |
|
- First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
|
| 15 |
NCT03414333 |
Recruiting |
To Determine the Effect of GLP1 on Cognitive Function, Brain Glucose Metabolism and Neuroplasticity. |
- Glucose Metabolism Disorders
- Obesity
- Degenerative Brain Disorder
|
- Procedure: RYGB
- Drug: GLP-1
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- sustained Weight Loss
- glycemic Control
|
50 |
All |
18 Years to 60 Years (Adult) |
NCT03414333 |
PRA 2016 |
|
June 29, 2016 |
June 2018 |
December 2020 |
January 29, 2018 |
January 29, 2018 |
|
- Dept.Clinical and Experimental Medicine.Section of Diabetes.
Pisa, Italy
|
| 16 |
NCT03390192 |
Recruiting |
Noninvasive Dual-mode Stimulation Therapy for Neurorehabilitation in Stroke |
|
- Device: Dual-mode stimulation
- Device: Single sham stimulation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Fugl-Meyer Assessment score
|
60 |
All |
19 Years and older (Adult, Senior) |
NCT03390192 |
2013-06-002-009 |
|
January 13, 2015 |
January 13, 2020 |
January 13, 2020 |
January 4, 2018 |
January 4, 2018 |
|
- Samsung Medical Center
Seoul, Korea, Republic of
|
| 17 |
NCT03233100 |
Recruiting |
FMT Treating Constipation Patients With Depression and/or Anxiety Symptoms - Clinical Efficacy and Potential Mechanisms |
- Constipation - Functional
- Depressive Symptoms
- Anxiety Symptoms
- Gut-Brain Disorders
|
|
Interventional |
Not Applicable |
- Jianfeng Gong
- Jinling Hospital, China
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- CSBMs per week
- HAMA
- HAMD
- (and 4 more...)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03233100 |
STC-D-A-2017-FMT |
|
July 30, 2017 |
December 31, 2018 |
December 31, 2018 |
July 28, 2017 |
July 28, 2017 |
|
- Department of Generay Surgery, Jinling hosptal, Medical School of Nanjing University
Nanjing, Jiangsu, China
|
| 18 |
NCT03071861 |
Recruiting |
Mild Encephalopathy in the Newborn Treated With Darbepoetin |
- Neonatal Encephalopathy
- Hypoxic-Ischemic Encephalopathy Mild
|
- Drug: Darbepoetin Alfa
- Drug: Normal Saline
|
Interventional |
Phase 2 |
- University of New Mexico
- University of Utah
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Neurodevelopmental outcome
- Percent of infants with adverse events
- Percent of infants with seizures
- (and 5 more...)
|
40 |
All |
up to 24 Hours (Child) |
NCT03071861 |
MEND 16-330 |
MEND |
December 1, 2017 |
October 31, 2019 |
October 31, 2020 |
March 7, 2017 |
January 9, 2018 |
|
- UNM Children's Hospital
Albuquerque, New Mexico, United States - University of Utah
Salt Lake City, Utah, United States
|
| 19 |
NCT03122808 |
Recruiting |
Uterine Activity in Moderate-Severe Neonatal Encephalopathy: A Case Control Study |
|
- Diagnostic Test: Uterine Activity Analysis
- Diagnostic Test: Partogram Analysis
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Retrospective
|
- Rest interval duration
- Rest interval as a percentage of contraction-rest interval cycle
|
300 |
All |
Child, Adult, Senior |
NCT03122808 |
REC-2015-009 |
|
September 1, 2016 |
January 2018 |
July 2018 |
April 21, 2017 |
April 24, 2017 |
|
- The Rotunda Hospital
Dublin, Co. Dublin, Ireland
|
| 20 |
NCT02812433 |
Recruiting |
Sildenafil Administration to Treat Neonatal Encephalopathy |
|
- Drug: Sildenafil
- Drug: Ora-Blend
|
Interventional |
Phase 1 |
- McGill University Health Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Serious adverse events
- Plasmatic concentrations of sildenafil and N-desmethyl sildenafil
|
80 |
All |
up to 48 Hours (Child) |
NCT02812433 |
15-364-MUHC |
SANE |
July 2016 |
June 2022 |
June 2022 |
June 24, 2016 |
August 30, 2017 |
|
- Montreal Children's Hospital
Montreal, Quebec, Canada
|
| 21 |
NCT02544100 |
Recruiting |
Neonatal Neurologic Intensive Care Network of China |
- Neonatal Encephalopathy
- Suspected Neonatal Encephalopathy
|
- Other: Database Entry/Biospecimen Collection
|
Observational |
|
- Children's Hospital of Fudan University
- Xiamen Children's Hospital, Fujian of China
- Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
- (and 6 more...)
|
Other |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Number of Blood Samples
- Number of Urine Samples
- Number of Electronic Medical Records
- (and 3 more...)
|
2000 |
All |
up to 28 Days (Child) |
NCT02544100 |
CHFudanU_NNICU5 |
|
September 2015 |
December 2020 |
December 2020 |
September 9, 2015 |
October 18, 2017 |
|
- Children Hospital of Fudan University
Shanghai, Shanghai, China
|
| 22 |
NCT01694953 |
Recruiting |
The Natural History Study of Mitochondrial NeuroGastroIntestinal Encephalopathy (MNGIE) |
- Mitochondrial NeuroGastroIntestinal Encephalopathy (MNGIE)
|
|
Observational |
|
- Columbia University
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Timed Water Swallow
- Degree of Neuropathy
|
10 |
All |
5 Years and older (Child, Adult, Senior) |
NCT01694953 |
AAAI5453
1U54NS078059 |
NAHIM |
February 2013 |
June 2020 |
June 2020 |
September 27, 2012 |
August 9, 2016 |
|
- Columbia University
New York City, New York, United States
|
| 23 |
NCT01846663 |
Recruiting |
Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy |
|
- Drug: Placebo
- Drug: Rifaximin
|
Interventional |
Phase 4 |
- Valeant Pharmaceuticals International, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time to first Hepatic Encephalopathy(HE) breakthrough episode
- Time to first HE-related hospitalization
- All Cause Mortality
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT01846663 |
RFHE4043 |
|
April 3, 2013 |
May 2021 |
June 2021 |
May 3, 2013 |
April 27, 2017 |
|
- The University of Alabama at Birmingham
Birmingham, Alabama, United States - Banner Research
Phoenix, Arizona, United States - University Of Arizona Liver Research Institute
Tucson, Arizona, United States - (and 25 more...)
|
| 24 |
NCT03448770 |
Recruiting |
To Compare Efficacy and Safety of Lactulose Versus Polyethylene Glycol for Treatment of Overt Hepatic Encephalopathy in Cirrhotics. |
|
- Drug: PEG- 17 gm sachet
- Drug: Lactulose : 20-30gm
|
Interventional |
Not Applicable |
- Institute of Liver and Biliary Sciences, India
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Complete reversal of hepatic encephalopathy in both groups.
- Improvement in hepatic encephalopathy by two grades in both groups
- Length of Intensive Care Unit stay in both groups
- (and 2 more...)
|
110 |
All |
18 Years to 65 Years (Adult) |
NCT03448770 |
ILBS-cirrhosis-14 |
|
August 1, 2017 |
July 31, 2018 |
July 31, 2018 |
February 28, 2018 |
February 28, 2018 |
|
- Institute of liver and Biliary Sciences
New Delhi, Delhi, India
|
| 25 |
NCT03439982 |
Recruiting |
Fecal Transplant for Hepatic Encephalopathy |
|
|
Interventional |
Phase 1
Phase 2 |
- University of Alberta
- Rebiotix Inc.
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to HE breakthrough
- ICT
- Stroop
- (and 2 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03439982 |
Pro00060782 |
|
April 12, 2016 |
April 12, 2021 |
April 12, 2022 |
February 20, 2018 |
February 20, 2018 |
|
- University of Alberta Hospital
Edmonton, Alberta, Canada
|
| 26 |
NCT03420482 |
Recruiting |
Fecal Microbiota Transplant as Treatment of Hepatic Encephalopathy |
|
- Drug: Fecal Microbiota Transplant (FMT) oral capsules
- Drug: Placebo oral capsule
|
Interventional |
Phase 2 |
- Massachusetts General Hospital
- Center for Microbiome Informatics and Therapeutics
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Psychometric Hepatic Encephalopathy Score (PHES)
- Adverse events
- Stroop Test
- (and 3 more...)
|
30 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03420482 |
2017P002296 |
|
April 1, 2018 |
March 31, 2019 |
December 31, 2020 |
February 2, 2018 |
March 30, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
| 27 |
NCT03372499 |
Recruiting |
Diet Management on Hepatic Encephalopathy of Patients With Variceal Bleeding After Intrahepatic Portosystemic Shunt Creation |
|
- Dietary Supplement: diet management strategy for encephalopathy
|
Interventional |
Not Applicable |
- Li Yang
- West China Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Incidence of Hepatic Encephalopathy
- Liver Transplantation-free Survival Rate
- Incidence of Stent Dysfunction
- (and 3 more...)
|
86 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03372499 |
DM-PTHE |
DM-PTHE |
October 1, 2017 |
November 2018 |
December 2018 |
December 13, 2017 |
December 13, 2017 |
|
- West China Hospital, Sichuan University
Chengdu, Sichuan, China
|
| 28 |
NCT03306498 |
Not yet recruiting |
Plasma Free Amino Acids in Patients With Hepatic Encephalopathy |
|
- Drug: Aminoleban (8% amino acids infusion)
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Amino acid profile in hepatic encephalopathy
- Relation between amino acids and nutrition
- IV Amino acids infusion effect
|
100 |
All |
18 Years to 65 Years (Adult) |
NCT03306498 |
amino acids in liver cirrhosis |
|
December 15, 2017 |
December 15, 2018 |
February 15, 2019 |
October 11, 2017 |
October 11, 2017 |
|
|
| 29 |
NCT03115697 |
Recruiting |
High Volume Plasmapheresis for Refractory Hepatic Encephalopathy in Liver Intensive Care Unit. |
- Refractory Hepatic Encephalopathy
|
- Drug: Lactulose
- Drug: Rifaximin
- Biological: Plasmapheresis
|
Interventional |
Not Applicable |
- Institute of Liver and Biliary Sciences, India
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Resolution in Hepatic Encephalopathy by 2 grades in both groups
- Improvement in Hepatic Encephalopathy in both groups
- Number of days of mechanical ventilation in both groups
- (and 3 more...)
|
120 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03115697 |
ILBS-HE-01 |
|
April 7, 2018 |
April 15, 2019 |
April 15, 2019 |
April 14, 2017 |
April 10, 2018 |
|
- Institute of Liver and Biliary Sciences
New Delhi, Delhi, India
|
| 30 |
NCT03100513 |
Recruiting |
PEG (Polyethylene Glycol)Versus Lactulose For Treatment Of Overt Hepatic Encephalopathy |
|
- Drug: Lactulose
- Drug: Polyethylene Glycol
|
Interventional |
Phase 4 |
- Sherief Abd-Elsalam
- Tanta University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- 1 or more in HE grade improvement at 24 hours
- Time to HE resolution
- Overall length of stay
|
100 |
All |
Child, Adult, Senior |
NCT03100513 |
Hanan Soliman |
|
March 11, 2017 |
October 2019 |
December 2019 |
April 4, 2017 |
April 27, 2017 |
|
- Tropical medicine dept.-Tanta university hospital
Cairo, Egypt
|
| 31 |
NCT03077217 |
Not yet recruiting |
Low-dose Rifaximin in the Treatment of Covert Hepatic Encephalopathy |
- Covert Hepatic Encephalopathy
|
|
Interventional |
Phase 4 |
- Shanghai Changzheng Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Percentage of patients showing covert hepatic encephalopathy reversal
- health-related quality of life improvement
|
120 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03077217 |
CZH0010 |
|
May 1, 2017 |
December 31, 2017 |
March 31, 2018 |
March 10, 2017 |
March 10, 2017 |
|
|
| 32 |
NCT02464124 |
Recruiting |
Nitazoxanide Plus Lactulose Versus Lactulose Alone Treatment of Hepatic Encephalopathy |
|
- Drug: Nitazoxanide
- Drug: Lactulose
|
Interventional |
Phase 2
Phase 3 |
- Sherief Abd-Elsalam
- Tanta University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Number of patients with total reversal of hepatic encephalopathy
|
120 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02464124 |
Hepatic encephalopathy |
|
January 2016 |
December 2017 |
December 2017 |
June 8, 2015 |
August 21, 2017 |
|
- Tanta university - faculty of medicine
Tanta, Elgharbia, Egypt
|
| 33 |
NCT02255617 |
Recruiting |
Fecal Microbiota Transplantation (FMT) in the Management of Hepatic Encephalopathy (HE): a Pilot Study |
|
- Biological: Fecal Microbiota Transplant
|
Interventional |
Phase 1
Phase 2 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to hepatic encephalopathy breakthrough
|
10 |
All |
18 Years to 65 Years (Adult) |
NCT02255617 |
47057 |
|
July 2014 |
December 2017 |
December 2018 |
October 2, 2014 |
January 13, 2017 |
|
- University of Alberta Hospital
Edmonton, Alberta, Canada
|
| 34 |
NCT03414021 |
Recruiting |
Interest of the SPECT-CT Scan SUVspect in the New Generation of Gamma-cameras With Semiconductor |
- Thyroid Diseases
- Heart Diseases
- Bone Diseases
- (and 2 more...)
|
- Diagnostic Test: SPECT-CT Scan
|
Observational |
|
- Lille Catholic University
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- SUVspect
- Matrix size
- duration of image acquisition
|
250 |
All |
18 Years and older (Adult, Senior) |
NCT03414021 |
OBS-0030 |
GAMMA-CAM |
January 31, 2018 |
January 30, 2023 |
January 30, 2023 |
January 29, 2018 |
January 29, 2018 |
|
- Humanitep
Lomme, Hauts De France, France - Hopital Privé Le Bois
Lille, Hauts-de-France, France
|
| 35 |
NCT03295786 |
Recruiting |
Clinical Study to Test the Safety of CDNF by Brain Infusion in Patients With Parkinson's Disease |
- Parkinson Disease
- Movement Disorders
- Neurodegenerative Diseases
- (and 2 more...)
|
- Drug: Cerebral Dopamine Neurotrophic Factor
- Device: Renishaw Drug Delivery System
|
Interventional |
Phase 1
Phase 2 |
- Herantis Pharma Plc.
- Renishaw plc.
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Adverse events (AEs)
- Electrocardiogram (ECG)
- Beck Depression Inventory (BDI) score
- (and 16 more...)
|
18 |
All |
35 Years to 75 Years (Adult, Senior) |
NCT03295786 |
HP-CD-CL-2002
2015-004175-73 |
|
September 26, 2017 |
August 2019 |
November 2019 |
September 28, 2017 |
April 11, 2018 |
|
- Helsinki University Hospital
Helsinki, Finland - Skåne University Hospital
Lund, Sweden - Karolinska University Hospital, Huddinge
Stockholm, Sweden
|
| 36 |
NCT02080286 |
Recruiting |
Transcranial Stimulation (tDCS) and Prism Adaptation in Spatial Neglect Rehabilitation |
- Spatial Neglect
- Stroke
- Cerebrovascular Disorders
- (and 2 more...)
|
- Behavioral: Prism Adaptation
- Device: Anodal tDCS
- Device: Sham tDCS
|
Interventional |
Not Applicable |
- University of Oxford
- National Institute for Health Research, United Kingdom
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Behavioural Inattention Test (BIT)
- Neglect Test Battery
- Changes in brain imaging data
|
40 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02080286 |
12/sc/0556 |
|
February 2014 |
May 2018 |
December 2019 |
March 6, 2014 |
October 11, 2017 |
|
- FMRIB Centre, John Radcliffe Hospital, University of Oxford
Oxford, United Kingdom
|
| 37 |
NCT02931682 |
Recruiting |
Observational Study of Males With Creatine Transporter Deficiency |
- Creatine Deficiency, X-linked
|
|
Observational |
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Clinical Global Impression Scale
- Mullen Scales of Early Learning
- Electroencephalogram
|
50 |
Male |
6 Months to 65 Years (Child, Adult) |
NCT02931682 |
LUM-001-C-01 |
Vigilan |
October 2016 |
September 2020 |
February 2021 |
October 13, 2016 |
April 5, 2018 |
|
- University of California San Diego
La Jolla, California, United States - Rush University Medical Center
Chicago, Illinois, United States - National Institutes of Health Clinical Center
Bethesda, Maryland, United States - (and 6 more...)
|
| 38 |
NCT03166215 |
Recruiting |
Study of TAK-935 as an Adjunctive Therapy in Participants With Developmental and/or Epileptic Encephalopathies |
- Developmental and/or Epileptic Encephalopathies
|
- Drug: TAK-935
- Drug: Placebo
|
Interventional |
Phase 1
Phase 2 |
- Takeda
- Ovid Therapeutics Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percentage of Participants with at least One Treatment-Emergent Adverse Event (TEAE), as Reported by the Participants or Participants' Caregivers or Observed by the Investigator, After TAK-935 Treatment
- Oral Clearance (CL/F) and Intercompartmental Clearance (Q) for TAK-935
- Apparent Volume of Distribution (Vz/F) of Central Compartment (Vc) and Peripheral Compartment (Vp) for TAK-935
- (and 6 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT03166215 |
TAK-935-2001
U1111-1192-7890 |
|
June 13, 2017 |
July 31, 2018 |
December 31, 2018 |
May 25, 2017 |
April 12, 2018 |
|
- Xenoscience
Phoenix, Arizona, United States - Medsol Clinical Research Center
Port Charlotte, Florida, United States - University of South Florida
Tampa, Florida, United States - (and 8 more...)
|
| 39 |
NCT03024827 |
Recruiting |
Cannabidiol in Children With Refractory Epileptic Encephalopathy |
|
|
Interventional |
Phase 1 |
- University of Saskatchewan
- University of Alberta
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Heart Rate
- Blood Pressure
- Weight
- (and 19 more...)
|
30 |
All |
1 Year to 10 Years (Child) |
NCT03024827 |
CARE-E-01 |
CARE-E |
April 26, 2017 |
September 2018 |
December 2018 |
January 19, 2017 |
February 5, 2018 |
|
- University of Alberta
Edmonton, Alberta, Canada - University of British Columbia
Vancouver, British Columbia, Canada - University of Manitoba
Winnipeg, Manitoba, Canada - (and 2 more...)
|
| 40 |
NCT02831010 |
Recruiting |
A Multi-Center Cohort Study of Risk Factors and Outcomes of Encephalopathy of Prematurity in China |
|
|
Observational |
|
- Children's Hospital of Fudan University
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- developmental quotient (DQ) on the Gesell Developmental Schedules
- brain injury showed on MRI
- morbidity of encephalopathy of prematurity
- (and 2 more...)
|
1500 |
All |
up to 28 Days (Child) |
NCT02831010 |
EKYYEOPMC |
|
April 2014 |
December 2018 |
December 2018 |
July 13, 2016 |
September 20, 2017 |
|
- The First People's Hospital of Hefei
Hefei, Anhui, China - Xiamen Women's and Children's Health Centre
Xiamen, Fujian, China - People's Hospital of Zhangzhou
Zhangzhou, Fujian, China - (and 11 more...)
|
| 41 |
NCT01536327 |
Recruiting |
Biomarker for Metachromatic Leukodystrophy Disease |
- Leukodystrophy, Metachromatic
- Hereditary Central Nervous System Demyelinating Diseases
- Brain Diseases, Metabolic, Inborn
- (and 2 more...)
|
|
Observational |
|
- University of Rostock
- Centogene AG Rostock
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Development of a new MS-based biomarker for the early and sensitive diagnosis of Metachromatic Leukodystrophy disease from plasma and saliva
- Testing for clinical robustness, specificity and long-term stability of the biomarker
|
80 |
All |
Child, Adult, Senior |
NCT01536327 |
BMLE11/2011 |
BioMeta |
September 2011 |
September 2018 |
October 2018 |
February 22, 2012 |
May 4, 2017 |
|
- Pediatric practice
Oran, Algeria - University of Rostock, Albrecht-Kossel-Institute for Neuroregeneration
Rostock, Germany - NIRMAN, University of Mumbai
Mumbai, India
|
| 42 |
NCT03409770 |
Not yet recruiting |
Cooling in Mild Encephalopathy |
- Neonatal Encephalopathy
- Hypothermia Neonatal
- Magnetic Resonance Spectroscopy
|
- Other: Therapeutic hypothermia
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Thalamic N-acetyl aspartate level
- Brain injury on conventional MR imaging
- Hospital stay
- (and 2 more...)
|
220 |
All |
up to 6 Hours (Child) |
NCT03409770 |
241031 |
COMET |
April 2018 |
March 2020 |
April 2020 |
January 24, 2018 |
January 24, 2018 |
|
- Medway NHS Foundation Trust
Gillingham, United Kingdom - Imperial College Healthcare NHS Trust
London, United Kingdom - The Newcastle Upon Tyne NHS Foundation Trust
Newcastle, United Kingdom
|
| 43 |
NCT03380013 |
Recruiting |
OMT to Improve Feeding After Hypothermia |
- Neonatal Encephalopathy
- Feeding; Difficult, Newborn
|
- Procedure: Osteopathic Manipulative Treatment (OMT)
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Total hospital length of stay
- Number of days until full oral feeding is achieved
- Patterns of somatic dysfunction
|
12 |
All |
37 Weeks and older (Child, Adult, Senior) |
NCT03380013 |
IRB 1134889-1 |
|
October 24, 2017 |
April 2018 |
April 2018 |
December 20, 2017 |
December 20, 2017 |
|
- Maine Medical Center
Portland, Maine, United States
|
| 44 |
NCT02822027 |
Recruiting |
Intravenous Immunoglobin Transfusion in Preterm Infants With Encephalopathy of Prematurity |
|
- Drug: human gamma globulin
- Drug: non-human gamma globulin
|
Interventional |
Not Applicable |
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- structural changes of brain injury
- functional changes of brain injury
|
20 |
All |
up to 6 Hours (Child) |
NCT02822027 |
IVIG for encephalopathy |
|
June 2016 |
July 2018 |
|
July 4, 2016 |
July 4, 2016 |
|
- Department of Pediatrics,Daping Hospital
Chongqing, Chongqing, China
|
| 45 |
NCT02603991 |
Recruiting |
Prospective Cohort Study on the Efficacy of Vagus Nerve Stimulation for Children and Adolescents With Epilepsy(PVNS-CAE) |
|
- Procedure: PINS Vagus Nerve Stimulator
- Drug: Levetiracetam
|
Observational |
|
- Beijing Pins Medical Co., Ltd
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The change of the score in Quality of Life in Children with Epilepsy
- Respondent rate
- seizure free rate
- complication
|
1 |
All |
4 Years to 18 Years (Child, Adult) |
NCT02603991 |
PINS-015 |
|
June 2016 |
January 2017 |
October 2017 |
November 13, 2015 |
October 13, 2016 |
|
- Beijing Tiantan Hospital
Beijing, Beijing, China
|
| 46 |
NCT02550054 |
Recruiting |
Erythropoietin in Premature Infants to Prevent Encephalopathy |
|
- Drug: Epo
- Drug: Normal saline
|
Interventional |
Phase 2 |
- Children's Hospital of Fudan University
- Xiamen Children's Hospital, Fujian of China
- Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
- (and 4 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Neurodevelopment(Bayley Scores)
- Neurological Evaluation(GMFM-88 Scores)
- Brain Structural Alterations(MRI)
- (and 9 more...)
|
312 |
All |
up to 48 Hours (Child) |
NCT02550054 |
CHFudanU_NNICU4 |
|
September 2015 |
December 2018 |
December 2018 |
September 15, 2015 |
January 26, 2018 |
|
- Children Hospital of Fudan University
Shanghai, Shanghai, China
|
| 47 |
NCT02451618 |
Recruiting |
Novel Epidermal Recording and Detection of Seizures |
- Seizures
- Encephalopathy
- Asphyxiated Newborn
|
|
Observational |
|
- Sharp HealthCare
- The Gerber Foundation
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Seizure detection
- EEG characterization
- Skin integrity from standard EEG vs study electrodes
- Hair removal from standard EEG vs study electrodes
|
60 |
All |
Child, Adult, Senior |
NCT02451618 |
Epidermal Electronics |
NERDS |
May 2015 |
November 2017 |
November 2018 |
May 22, 2015 |
November 10, 2016 |
|
- Sharp Mary Birch Hospital for Women and Newborns
San Diego, California, United States
|
| 48 |
NCT02387385 |
Recruiting |
Hypothermia for Encephalopathy in Low and Middle-Income Countries Trial |
|
- Device: Whole body cooling (Tecotherm)
|
Interventional |
Not Applicable |
- Thayyil, Sudhin
- Madras Medical College
- Manipal Hospital, India
- (and 7 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Composite outcome of Death or moderate or severe neurodisability
- Mortality from any cause
- Major intracranial haemorrhage
- (and 16 more...)
|
408 |
All |
up to 6 Hours (Child) |
NCT02387385 |
15HH |
HELIX |
August 2015 |
April 2019 |
April 2019 |
March 13, 2015 |
April 5, 2018 |
|
- Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh - Institute of Obstetrics and Gynaecology
Chennai, TamilNadu, India - Indira Gandhi Institute of Child Health
Bangalore, India - (and 6 more...)
|
| 49 |
NCT02418039 |
Recruiting |
High Protein Diet Versus Normal Protein Diet in Treating Patients With Minimal Hepatic Encephalopathy |
|
- Dietary Supplement: High protein diet
- Dietary Supplement: Normal protein
|
Interventional |
Not Applicable |
- Coordinación de Investigación en Salud, Mexico
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Reversal of minimal hepatic encephalopathy (number of patients who reverts the minimal hepatic encephalopathy after dietary intervention)
- Nutritional Status
|
80 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02418039 |
R-2014-785-007 |
|
March 10, 2017 |
August 2019 |
December 2019 |
April 16, 2015 |
April 12, 2017 |
|
- Instituto Mexicano del Seguro Social
Mexico, Distrito Federal, Mexico
|
| 50 |
NCT02156232 |
Recruiting |
Embolization of Large Spontaneous Portosystemic Shunts for the Prevention of Post-TIPS Refractory Hepatic Encephalopathy |
|
- Procedure: TIPS
- Procedure: embolization
|
Interventional |
Not Applicable |
- Fourth Military Medical University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- number and severiy of participants with HE, espcially the refractory HE
- number of participants with variceal rebleeding
- number of participants with shunt dysfunction
- (and 2 more...)
|
40 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02156232 |
TIPS-SPSS |
|
June 2014 |
December 2017 |
December 2017 |
June 5, 2014 |
July 7, 2017 |
|
- Xijing Hospital of Digestive Diseases, Fourth Military Medical University
Xi'an, Shaanxi, China
|
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