| 1 |
NCT02890134 |
Recruiting |
Molecular Reclassification to Find Clinically Useful Biomarkers for Systemic Autoimmune Diseases: Inception Cohort |
- Systemic Autoimmune Diseases
|
|
Observational
|
|
- Fundación Pública Andaluza Progreso y Salud
- UCB Biopharma S.P.R.L.
- Atrys Health, SA.
- (and 27 more...)
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Gene expression in total blood
- Flow cytometry analysis to determine cell proportions in the total blood mixture in all individuals.
- Genotyping
- (and 5 more...)
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT02890134 |
PRECISESADS INCP (RB 15.007) |
PRECISESADSI |
June 2015 |
January 2019 |
January 2019 |
September 7, 2016 |
December 12, 2016 |
|
- Université catholique de Louvain - Cliniques Universitaires Saint-Luc (UCL)
Brussels, Belgium - UZ Leuven - KU Leuven, Department of Rheumatology (KU LEUVEN)
Leuven, Belgium - CHRU de Brest
Brest, France - (and 7 more...)
|
|
| 2 |
NCT03140137 |
Recruiting |
Immune Checkpoint Inhibitors and Pre-existing Autoimmune Diseases |
- Autoimmune Diseases
- Advanced Cancer
|
- Drug: Checkpoint inhibitor therapy
|
Observational
|
|
- University Hospital, Brest
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Autoimmune disease flare
- Other immune/inflammatory complications
|
50 |
All |
18 Years and older (Adult, Older Adult) |
NCT03140137 |
CHECKAUTO |
|
January 23, 2017 |
January 23, 2018 |
January 23, 2018 |
May 4, 2017 |
October 4, 2017 |
|
- CH d'AIX
AIX en PROVENCE, France - CHU de DIJON
Dijon, France - CHD Vendée
La Roche-sur-Yon, France - (and 2 more...)
|
|
| 3 |
NCT03444805 |
Not yet recruiting |
EBMT ADWP Prospective Non-interventional Study: Post-AHSCT Management in SSC Patients (NISSC-2) |
|
- Procedure: Autologous HSCT
|
Observational
|
|
- European Group for Blood and Marrow Transplantation
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Progression free survival (PFS),
- Treatment related toxicity
- 100 days Treatment Related Mortality (100d TRM)
- (and 8 more...)
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03444805 |
ADWP 8410025 |
NISSC-2 |
June 1, 2018 |
December 31, 2019 |
March 30, 2020 |
February 23, 2018 |
May 1, 2018 |
|
- Badoglio Manuela- EBMT Paris Office
Paris, France
|
|
| 4 |
NCT02704338 |
Not yet recruiting |
Safety and Efficacy Study of Regulatory T Cells in Treating Autoimmune Hepatitis |
|
- Biological: Regulatory T cells
|
Interventional
|
Phase 1
Phase 2 |
- Nanjing Medical University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Biochemical remission(serum levels of alanine aminotransferase, aspartate aminotransferase and Total bilirubin within normal ranges)
- immunology remission(=serum levels of T cell subsets, immune globulin, and complement within normal ranges) and lack of other side effects.
- Incidence of biochemical remission 2 times increase of serum levels of alanine aminotransferase, aspartate aminotransferase and Total bilirubin.
- (and 2 more...)
|
30 |
All |
10 Years to 70 Years (Child, Adult, Older Adult) |
NCT02704338 |
NJLT002 |
Treg |
April 2016 |
March 2018 |
October 2018 |
March 10, 2016 |
March 10, 2016 |
|
|
|
| 5 |
NCT03266172 |
Recruiting |
A Study to Compare the Pharmacokinetics of GSK2982772 Following Administration of Different Modified Release (MR) Formulations in Capsule Relative to an Immediate Release (IR) Tablet Formulation and to Investigate the Pharmacokinetics of a Selected MR Formulation in Capsule Following Repeat Doses |
|
- Drug: GSK2982772 Modified Release (MR)
- Drug: GSK2982772 Immediate Release (IR)
|
Interventional
|
Phase 1 |
- GlaxoSmithKline
- Quotient Clinical
|
Industry / Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Area under the curve from time zero to infinity (AUC[0-inf]) of GSK2982772 for MR formulation in a capsule (120 mg) in Part A
- AUC(0-inf) of GSK2982772 for IR formulation (120 mg) in Part A
- Area under the curve from time zero to the last measurable concentration (AUC[0-t]) of GSK2982772 for MR formulation in a capsule (120 mg) in Part A
- (and 50 more...)
|
26 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03266172 |
205017 |
|
September 27, 2017 |
October 31, 2018 |
October 31, 2018 |
August 30, 2017 |
January 23, 2018 |
|
- GSK Investigational Site
Nottingham, United Kingdom
|
|
| 6 |
NCT03180190 |
Not yet recruiting |
Genetic Variants in Egyptian Patients Receiving HCQ(Hydroxychloroquine) |
|
- Drug: Hydroxychloroquine Oral Tablet
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- HCQ toxicity in Egyptian patients
- genetic variant
|
50 |
All |
18 Years to 60 Years (Adult) |
NCT03180190 |
Hydroxychloroquine |
HCQ |
June 28, 2017 |
June 28, 2018 |
July 28, 2018 |
June 8, 2017 |
June 9, 2017 |
|
|
|
| 7 |
NCT02458196 |
Recruiting |
Study of Treatment Response on IgG4 Related Disease (IgG4RD) |
|
- Drug: Prednisone
- Drug: Prednisone and Mycophenolate mofetil
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Complete and partial response rate at 3, 6, 9 and 12 months.
- Disease response at 3, 6, 9 and 12 months.
- Number of participants with adverse effect
|
60 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02458196 |
IgG4-02 |
|
April 2015 |
June 2017 |
June 2018 |
June 1, 2015 |
January 24, 2017 |
|
- Peking Union Medical College Hospital
Beijing, Beijing, China
|
|
| 8 |
NCT01665196 |
Recruiting |
18F-FDG PET/CT for IgG4-Related Disease |
|
|
Interventional
|
Early Phase 1 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Visual analysis of organ involvement and treatment response of the IgG4-RD patients.
- Semiquantitative measurement of lesion metabolism and treatment response of the IgG4-RD patients.
|
100 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT01665196 |
IgG4RD-PET |
|
September 2012 |
December 2017 |
December 2017 |
August 15, 2012 |
April 7, 2017 |
|
- Peking Union Medical College Hospital
Beijing, Beijing, China
|
|
| 9 |
NCT02822807 |
Recruiting |
Q Fever and Auto-immunity |
|
- Biological: Blood sampling
|
Interventional
|
Not Applicable |
- Assistance Publique Hopitaux De Marseille
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Occurrence of a complication, linked to the rate of autoantibodies.
- Rate of anti- cardiolipin antibodies
- Rate of anti- phagosome autoantibodies
|
300 |
All |
18 Years and older (Adult, Older Adult) |
NCT02822807 |
2013-31
2013-A00963-42 |
Q Fever |
July 2013 |
July 2018 |
January 2019 |
July 4, 2016 |
July 4, 2016 |
|
- Assistance Publique - Hôpitaux de Marseille
Marseille Cedex 05, France
|
|
| 10 |
NCT02899377 |
Recruiting |
A PH I Pilot Imaging Study to Evaluate Molecular Imaging Methods in HVs and pSS Pts |
|
- Radiation: 18F-FDG PET/CT Imaging
- Radiation: 11C-MET PET/CT Imaging
- Procedure: MRI Imaging with intravenous contrast with gadoterate meglumine
- Procedure: Minor Salivary gland (labial) biopsy
|
Interventional
|
Phase 1 |
- GlaxoSmithKline
- Quintiles, Inc.
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Standardized uptake volume (SUV) for 18^F FDG
- Tissue-to-reference ratio for 18^F FDG
- Total inflammatory volume (TIV) for 18^F FDG
- (and 9 more...)
|
24 |
All |
30 Years and older (Adult, Older Adult) |
NCT02899377 |
203818 |
|
November 18, 2016 |
June 19, 2018 |
June 19, 2018 |
September 14, 2016 |
June 19, 2018 |
|
- GSK Investigational Site
Cambridge, United Kingdom - GSK Investigational Site
Cambridge, United Kingdom - GSK Investigational Site
London, United Kingdom - (and 2 more...)
|
|
| 11 |
NCT02862301 |
Recruiting |
Epigenetic Evaluation of HAT/HDAC Activity in PBMC From Patients With Clinically Isolated Syndrome |
- Demyelinating Autoimmune Diseases, CNS
|
|
Interventional
|
Not Applicable |
- Centre Hospitalier Universitaire de Besancon
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- HDAC/ HAT enzymatic activity (ratio)
|
50 |
All |
18 Years to 60 Years (Adult) |
NCT02862301 |
API/2015/64 |
EPIC |
April 2016 |
April 2019 |
July 2019 |
August 11, 2016 |
August 11, 2016 |
|
- University Hospital
Besançon, France
|
|
| 12 |
NCT00716066 |
Recruiting |
Carmustine, Etoposide, Cytarabine, Melphalan, and Antithymocyte Globulin Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Autoimmune Neurologic Disease That Did Not Respond to Previous Therapy |
|
- Biological: Anti-Thymocyte Globulin
- Procedure: Autologous Hematopoietic Stem Cell Transplantation
- Drug: Carmustine
- (and 7 more...)
|
Interventional
|
Phase 2 |
- Fred Hutchinson Cancer Research Center
- National Cancer Institute (NCI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of grades 4-5 regimen-related toxicity as assessed by the Regimen Related Toxicity Scale
- Disease responses as assessed by clinical, laboratory and radiologic evaluation
- Engraftment kinetics
- (and 3 more...)
|
40 |
All |
up to 70 Years (Child, Adult, Older Adult) |
NCT00716066 |
2260.00
NCI-2010-00403
P30CA015704 |
|
June 2008 |
December 1, 2018 |
December 1, 2021 |
July 16, 2008 |
January 18, 2018 |
|
- Colorado Blood Cancer Institute
Denver, Colorado, United States - Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, United States - Swedish Medical Center-First Hill
Seattle, Washington, United States
|
|
| 13 |
NCT02715323 |
Recruiting |
Exploring Immune Cell Signatures in Autoimmunity and Dry Eye Syndrome |
- Autoimmunity
- Dry Eye Syndrome
|
- Other: Cross-sectional study
|
Observational
|
|
- Singapore National Eye Centre
- SingHealth Translational Immunology and Inflammation Centre
- TTSH Eye Clinic
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Dry Eye Symptoms (SPEED Questionnaire)
- Non-invasive Tear Break-up Time (NIKBUT)
- Conjunctival Redness Grading with Oculus Keratograph 5M
- (and 4 more...)
|
160 |
All |
21 Years to 99 Years (Adult, Older Adult) |
NCT02715323 |
R1295/101/2015 (SERI-STIIC-3)
2016/2048 |
|
May 2016 |
December 2019 |
December 2019 |
March 22, 2016 |
April 18, 2018 |
|
- Cynthia Boo
Singapore, Singapore
|
|
| 14 |
NCT02671188 |
Not yet recruiting |
A Study to Evaluate the Safety, Mode of Action and Clinical Efficacy of GSK3050002 in Subjects With Psoriatic Arthritis |
|
- Drug: GSK3050002
- Drug: Placebo
|
Interventional
|
Phase 1 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of subjects with Adverse Events (AE)
- Number of subjects with Serious Adverse Events
- Composite of clinical laboratory assessments as a measure of safety and tolerability.
- (and 15 more...)
|
18 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02671188 |
200928 |
|
June 1, 2018 |
August 9, 2019 |
August 9, 2019 |
February 2, 2016 |
July 14, 2017 |
|
- GSK Investigational Site
Oxford, United Kingdom
|
|
| 15 |
NCT03370627 |
Recruiting |
Effect of Anti-CD303 Antibodies in Autoimmune Diseases |
|
- Biological: Monoclonal anti-cd303 antibody
|
Interventional
|
Not Applicable |
- University Hospital, Lille
- Laboratoire français de Fractionnement et de Biotechnologies
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- in vitro determination of the level of type I interferons by immunoenzymatic ELISA method.
- in vitro determination of the level of type I interferons by immunoassay ELISA (by type of MIA)
- in vitro determination of the level of type I interferons by ELISA immunoassay method in patients treated or not with immunosuppressive or immunomodulatory treatment.
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT03370627 |
2017_23
2017_A02244-49 |
ANTI-CD303 |
December 20, 2017 |
January 2020 |
January 2020 |
December 12, 2017 |
May 8, 2018 |
|
- Hôpital Claude Huriez, CHU
Lille, France
|
|
| 16 |
NCT02525835 |
Not yet recruiting |
Tissue Sodium in Autoimmune Disease |
- Systemic Lupus Erythematosus
|
- Dietary Supplement: Low Dietary Sodium
- Dietary Supplement: High Dietary Sodium
|
Interventional
|
Not Applicable |
- Vanderbilt University
- Vanderbilt University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- sodium concentration in skin
- SLEDAI
- blood pressure
|
21 |
All |
18 Years and older (Adult, Older Adult) |
NCT02525835 |
150713 |
|
December 1, 2018 |
August 2020 |
August 2020 |
August 17, 2015 |
January 25, 2018 |
|
- Vanderbilt University
Nashville, Tennessee, United States
|
|
| 17 |
NCT03276923 |
Recruiting |
Maternal Autoimmune Disease Research Alliance (MADRA) Registry |
- Autoimmune Diseases
- Pregnancy Related
- Systemic Lupus Erythematosus
- (and 4 more...)
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Risk factors associated with poor pregnancy outcomes as measured by the MADRA-DAP questionnaire.
|
1000 |
Female |
Child, Adult, Older Adult |
NCT03276923 |
Pro00084014 |
MADRA |
January 1, 2018 |
January 1, 2027 |
January 1, 2027 |
September 8, 2017 |
February 2, 2018 |
|
- Duke University
Durham, North Carolina, United States
|
|
| 18 |
NCT01733082 |
Recruiting |
The Mycophenolate Pregnancy Registry |
- Heart Transplantation, Kidney Transplantation, Liver Transplantation, Autoimmune Diseases
|
|
Observational
|
|
- Genentech, Inc.
- Accord Healthcare, Inc.
- Sandoz
- (and 8 more...)
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Maternal outcomes: Incidence of pregnancy complications
- Fetal outcomes: Incidence of congenital disorders
- Time/duration of mycophenolate exposure
- (and 4 more...)
|
500 |
Female |
Child, Adult, Older Adult |
NCT01733082 |
ML22679 |
|
November 2012 |
March 2021 |
March 2021 |
November 26, 2012 |
November 2, 2016 |
|
- Cambridge, Massachusetts, United States
|
|
| 19 |
NCT03122431 |
Recruiting |
Relevance of Monitoring Blood and Salivar Levels of Drugs Used in Rheumatic Autoimmune Diseases |
- Systemic Lupus Erythematosus (SLE)
- Juvenile SLE
- Cutaneous Lupus
|
- Drug: Thalidomide
- Drug: Hydroxychloroquine reduced
- Drug: Hydroxychloroquine high
|
Interventional
|
Phase 4 |
- University of Sao Paulo General Hospital
- Fundação de Amparo à Pesquisa do Estado de São Paulo
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Serum levels of thalidomide
- Serum levels of hydroxycloroquine - HCQ reduced
- Serum levels of hydroxycloroquine - HCQ high
|
296 |
All |
5 Years to 64 Years (Child, Adult) |
NCT03122431 |
HPLC-Rheumatic diseases |
|
June 5, 2017 |
June 1, 2020 |
June 5, 2022 |
April 20, 2017 |
April 19, 2018 |
|
- Hospital das Clinicas da Faculdade de Medicina da USP
São Paulo, Brazil
|
|
| 20 |
NCT03193177 |
Recruiting |
Safety and Clinical Efficiency of the 21-day Fasting-like Diet in Patients With Metabolic and Autoimmune Diseases |
- Fasting
- Chronic Disease
- Autoimmune Diseases
- (and 6 more...)
|
- Other: the 21-day fasting-like diet
|
Interventional
|
Phase 1
Phase 2 |
- Tsinghua University
- Nanshan Branch of Qilu Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Number of participants with treatment-related adverse events as assessed by CTCAE v4.0.
- Evaluation of the therapeutic effects on metabolic disorder-associated diseases by the examination of metabolic biomarkers.
- Functional changes in the peripheral blood lymphocytes pre and post fasting-like diet as accesse by flow cytometry and RNA-seq.
- Compositional changes in intestinal microflora pre and post fasting-like diet as accesse by RNA-seq.
|
50 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03193177 |
THUMED-BG-170612 |
|
June 20, 2017 |
August 31, 2018 |
December 31, 2018 |
June 20, 2017 |
June 28, 2017 |
|
- Nanshan Branch of Qilu Hospital
Longkou, Shandong, China
|
|
| 21 |
NCT02985190 |
Recruiting |
A Study of Azacitidine in Myelodysplastic Syndrome (MDS) Associated to Systemic Auto-immune and Inflammatory Disorders |
- MDS
- Systemic Autoimmune Diseases
|
|
Interventional
|
Phase 2 |
- Groupe Francophone des Myelodysplasies
- Celgene
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Overall response rate of Myelodysplastic syndrome and systemic autoimmune and inflammatory diseases (SAID)
- Number of participants with treament-related adverse events as assessed by CTCAE v4.0
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT02985190 |
GFM-AZA-SAID
2016-000918-30 |
|
January 26, 2017 |
October 2020 |
October 2021 |
December 7, 2016 |
July 14, 2017 |
|
- CHU Amiens
Amiens cedex 01, France - CHU d'Angers
Angers cedex 9, France - Centre hospitalier Victor Dupouy
Argenteuil, France - (and 52 more...)
|
|
| 22 |
NCT02912442 |
Not yet recruiting |
Thyroid Autoimmunity and Reproductive Failure in Danish Women |
- Thyroid
- Infertility
- Autoantibodies
- (and 2 more...)
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
1200 |
Female |
Child, Adult, Older Adult |
NCT02912442 |
THY-FER-IMM |
|
December 2016 |
December 2019 |
December 2020 |
September 23, 2016 |
September 23, 2016 |
|
- Rigshospitalet
Copenhagen, Denmark
|
|
| 23 |
NCT03490539 |
Recruiting |
Disease-Modifying Treatments for Myasthenia Gravis |
- Neurological Disorder
- Autoimmune Diseases
|
- Drug: Mycophenolate Mofetil
- Drug: Azathioprine
|
Observational
|
|
- Duke University
- Beth Israel Deaconess Medical Center
- Patient-Centered Outcomes Research Institute
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in Patient-Reported Myasthenia Gravis Quality of Life, 15, revised ( MG-QOL15r)
- Change in composite outcome of clinical improvement and adverse effects
- Change in Myasthenia gravis composite (MGC) scores
- (and 5 more...)
|
220 |
All |
18 Years and older (Adult, Older Adult) |
NCT03490539 |
Pro00087883 |
PROMISE-MG |
May 7, 2018 |
November 1, 2020 |
November 1, 2020 |
April 6, 2018 |
June 5, 2018 |
|
- St. Elizabeth's Medical Center
Brighton, Massachusetts, United States - University at Buffalo, SUNY
Buffalo, New York, United States
|
|
| 24 |
NCT02502539 |
Recruiting |
Cellular and Molecular Adaptations to Exercise-induced Inflammatory Response in Children With Autoimmune Diseases |
- Juvenile Idiopathic Arthritis
|
- Procedure: Controlled physical activity
|
Interventional
|
Not Applicable |
- University Hospital, Clermont-Ferrand
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Percent change
- pain (VAS)
- locomotors function (CHAQ)
- (and 4 more...)
|
20 |
All |
8 Years to 12 Years (Child) |
NCT02502539 |
CHU-0234
2015-A00607-42 |
AJI-APA |
July 2015 |
October 2016 |
January 2017 |
July 20, 2015 |
July 26, 2016 |
|
- CHU de Clermont-Ferrand
Clermont-Ferrand, France
|
|
| 25 |
NCT03280797 |
Recruiting |
Feasibility of a Cytokine Expression Profile in Immune Cells as an Orientation Tool in Therapeutic Decisions for Auto-inflammatory and Auto-immune Diseases |
|
|
Interventional
|
Not Applicable |
- Centre Hospitalier Universitaire de Nīmes
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Dosage of cytokines between groups
- Creation of biobank
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03280797 |
LOCAL/2016/TAT01 |
IL-MAI |
November 24, 2017 |
June 2018 |
June 2018 |
September 13, 2017 |
December 15, 2017 |
|
- CHU de Montpellier
Montpellier, France - CHU Nimes
Nîmes, France
|
|
| 26 |
NCT03183869 |
Recruiting |
Fecal Microbial Transplantation in Relapsing Multiple Sclerosis Patients |
- Autoimmune Diseases
- Relapsing Multiple Sclerosis
|
|
Interventional
|
Phase 2 |
- Lawson Health Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effect of fecal microbial transplantation in peripheral blood cytokines within Relapsing Multiple Sclerosis patients
- Evaluate effect of fecal microbial transplantation in gut microbiome
- Evaluate effect of fecal microbial transplantation in gut permeability
- (and 2 more...)
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03183869 |
MS-FMT-001 |
|
August 24, 2017 |
December 2018 |
December 2018 |
June 12, 2017 |
November 24, 2017 |
|
- London Health Sciences Centre, University Hospital
London, Ontario, Canada
|
|
| 27 |
NCT02102594 |
Recruiting |
Therapy of Antibody-mediated Autoimmune Diseases by Bortezomib (TAVAB) |
- Myasthenia Gravis
- Systemic Lupus Erythematosus
- Rheumatoid Arthritis
|
|
Interventional
|
Phase 2 |
- Charite University, Berlin, Germany
- Prof. Dr. med. Falk Hiepe (Charité, Internal Medicine / Rheumathology)
- NeuroCure Clinical Research Center, Charite, Berlin
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- change in disease specific antibody titers after application of Bortezomib
- Change in disease specific antibody titer after Bortezomib application
- Change in quality of life (Qol score)
- (and 6 more...)
|
18 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02102594 |
TAVAB
2013-005362-19 |
TAVAB |
October 2014 |
December 2018 |
December 2018 |
April 3, 2014 |
February 2, 2018 |
|
- Charite - Universitätsmedizin Berlin, NeuroCure Clinical Research Center
Berlin, Germany - Charité - Universitätsmedizin Berlin, Internal Medicine / Rheumathology
Berlin, Germany
|
|
| 28 |
NCT03129308 |
Recruiting |
Prevalence of Cutaneous Autoimmune Phenomena in HIV Infected Patients |
- HIV Infections
- Autoimmune Diseases Affecting Skin
|
- Diagnostic Test: Blood Sampling
|
Observational
|
|
- Medical University of Vienna
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- prevalence of auto-antibodies against BPAG1/2
- prevalence of auto-antibodies against other cutaneous antigens
|
900 |
All |
18 Years and older (Adult, Older Adult) |
NCT03129308 |
1103/2017 |
|
April 3, 2017 |
September 2018 |
December 2018 |
April 26, 2017 |
March 22, 2018 |
|
- Medical University of Vienna, Department of Dermatology
Vienna, Austria
|
|
| 29 |
NCT02103361 |
Recruiting |
Stelara Pregnancy Exposure Registry OTIS Autoimmune Diseases in Pregnancy Project |
- Psoriasis
- Pregnancy
- Psoriatic Arthritis
- Crohn Disease
|
|
Observational
|
|
- University of California, San Diego
- The Organization of Teratology Information Specialists
- Janssen Biotech, Inc.
|
Other / Industry |
- Observational Model: Case-Only
- Time Perspective: Other
|
- Major structural malformations
- Minor Congenital Structural Malformations
|
100 |
Female |
Child, Adult, Older Adult |
NCT02103361 |
CNTO1275PSO4037 |
|
November 2013 |
November 2018 |
July 2020 |
April 3, 2014 |
March 27, 2017 |
|
- University of California, San Diego
La Jolla, California, United States
|
|
| 30 |
NCT01797224 |
Recruiting |
OTIS Autoimmune Diseases in Pregnancy Project |
- Crohn's Disease
- Rheumatoid Arthritis
- Ankylosing Spondylitis
- Psoriatic Arthritis
|
|
Observational
|
|
- University of California, San Diego
- The Organization of Teratology Information Specialists
- UCB Pharma
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Major malformations
- Minor malformations
- Pregnancy Outcome
- Infant follow-up
|
300 |
Female |
Child, Adult, Older Adult |
NCT01797224 |
RA0023 |
|
March 2012 |
December 2019 |
December 2022 |
February 22, 2013 |
March 24, 2017 |
|
- University of California, San Diego
San Diego, California, United States
|
|
| 31 |
NCT02257866 |
Recruiting |
Studies of the Natural History, Pathogenesis, and Outcome of Idiopathic Systemic Vasculitis |
- Autoimmune Disease
- Vascular Disease
|
|
Observational
|
|
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Other
|
- To study the pathogenesis of patients affected with idiopathic systemic vasculitis, including clinical, radiographic, immunological, and genetic characteristics of the disease
- Screening for other NIAMS clinical trials- To evaluate patients referred for suspected vasculitis and provide an additional medical opinion on diagnosis and make recommendations for treatment
- To develop long term clinical and laboratory outcome parameters of multiorgan involvement in patients with GPA, MPA, EGPA, PAN, TAK, and GCA- Evaluation of blood, body fluid, tissue, and imaging biomarkers during disease flares and quiescence
|
500 |
All |
5 Years and older (Child, Adult, Older Adult) |
NCT02257866 |
140200
14-AR-0200 |
|
October 4, 2014 |
September 1, 2018 |
September 1, 2018 |
October 7, 2014 |
April 23, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 32 |
NCT02421276 |
Recruiting |
Depressed AIRE Gene Expression Causes Immune Cell Dysfunction & Autoimmunity in Down Syndrome |
- Down Syndrome
- Polyendocrinopathies, Autoimmune
- Respiratory Tract Infections
- Autoimmunity
|
|
Interventional
|
Not Applicable |
- University of Colorado, Denver
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- AIRE Gene expression in Macrophage Subpopulations
- White blood cell Subpopulation Numbers
|
50 |
All |
up to 22 Years (Child, Adult) |
NCT02421276 |
14-2300 |
|
October 19, 2015 |
August 2018 |
September 2018 |
April 20, 2015 |
June 12, 2018 |
|
- University of Colorado, Denver
Denver, Colorado, United States
|
|
| 33 |
NCT03530995 |
Recruiting
New |
Drug-drug Interaction Study Between KD025, Itraconazole, Rifampicin and Rabeprazole in Healthy Volunteers |
- Drug Drug Interaction
- Autoimmune Diseases
- Fibrotic Disease
|
- Drug: KD025
- Drug: Itraconazole
- Drug: Rabeprazole
- Drug: Rifampicin
|
Interventional
|
Phase 1 |
- Kadmon Corporation, LLC
- Quotient Sciences Ltd.
|
Industry / Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in KD025 PK parameter Cmax when administered with itraconazole
- Change in KD025 parameter AUC when administered with itraconazole
- Change in KD025 PK parameter Cmax when administered with rabeprazole
- (and 11 more...)
|
40 |
Male |
18 Years to 55 Years (Adult) |
NCT03530995 |
KD025-107 |
|
April 28, 2018 |
July 16, 2018 |
July 20, 2018 |
May 21, 2018 |
May 21, 2018 |
|
- Quotient Sciences Ltd
Ruddington, Nottingham, United Kingdom
|
|
| 34 |
NCT02972801 |
Recruiting |
Testicular Tissue Cryopreservation for Fertility Preservation |
- Cancer
- Autoimmune Disorders
|
- Procedure: Testicular biopsy
|
Interventional
|
Not Applicable |
- University of Pittsburgh
- Children's Research Institute
- Children’s Hospital of Orange County
- (and 3 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Presence of spermatogonial stem cells in the testicular tissue as determined by histology.
|
250 |
Male |
Child, Adult, Older Adult |
NCT02972801 |
PRO09120485 |
|
January 2010 |
January 2021 |
January 2021 |
November 23, 2016 |
January 4, 2018 |
|
- Magee-Womens Hospital
Pittsburgh, Pennsylvania, United States
|
|
| 35 |
NCT03377218 |
Recruiting |
Potential Preventive Effect of Selenium on Iodine-induced Thyroid Autoimmunity During Pregnancy |
- Pregnancy
- Thyroid Autoimmune Disease
- Iodine Deficiency
- Selenium Deficiency
|
- Dietary Supplement: Iodine
- Dietary Supplement: Iodine + Selenium
|
Interventional
|
Not Applicable |
- Riga Stradins University
- Latvian Biomedical Research and Study Centre
- Riga Maternity hospital
- Latvian Institute of Organic Synthesis
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- UIC
- Change in anti-TPO Ab
- TSH
- fT4
|
300 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03377218 |
RigaStradinsU_Iodine3 |
|
January 5, 2018 |
December 2018 |
January 2019 |
December 19, 2017 |
April 19, 2018 |
|
- Riga Maternity hospital
Riga, Latvia
|
|
| 36 |
NCT03370861 |
Recruiting |
How Microbes and Metabolism May Predict Melanoma Treatment Outcomes |
|
- Biological: Immunotherapy
|
Observational
|
|
- Washington University School of Medicine
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Immune-related Adverse Events (irAEs)
- Overall Survival
|
125 |
All |
18 Years and older (Adult, Older Adult) |
NCT03370861 |
MINING |
MINING |
November 8, 2017 |
December 31, 2020 |
December 31, 2020 |
December 12, 2017 |
December 12, 2017 |
|
- Barnes-Jewish Hosptial
Saint Louis, Missouri, United States
|
|
| 37 |
NCT01611636 |
Recruiting |
Clinical Characteristics of Allergy, Autoimmune and Rheumatic Diseases: A Ten Year Retrospective Study |
- Allergy
- Autoimmune Diseases
- Rheumatic Diseases
|
|
Observational
|
|
- Far Eastern Memorial Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Incidence of target diseases
|
200000 |
All |
Child, Adult, Older Adult |
NCT01611636 |
100165-E |
|
January 2012 |
January 2022 |
January 2022 |
June 5, 2012 |
August 19, 2015 |
|
- Far Eastern Memorial Hospital
New Taipei City, Taiwan
|
|
| 38 |
NCT01758250 |
Recruiting |
Microvascular and Fibrosis Imaging Study |
- Autoimmune Diseases
- Sickle Cell Disease
- Chronic Graft Versus Host Disease
|
- Other: Acoustic Radiation Force Impulse (ARFI)
- Other: Laser Doppler Flowmetry (LDF)
- Other: Laser Doppler Perfusion Imaging (LDI)
- (and 3 more...)
|
Observational
|
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Microvascular density in oral mucosa and skin
- Microvascular Perfusion in oral mucosa and skin
|
220 |
All |
18 Years and older (Adult, Older Adult) |
NCT01758250 |
Pro00039256 |
|
February 2013 |
January 2019 |
December 2019 |
January 1, 2013 |
April 5, 2018 |
|
- Duke University Medical Center
Durham, North Carolina, United States
|
|
| 39 |
NCT00513591 |
Recruiting |
Duke Autoimmunity in Pregnancy Registry |
- Pregnancy
- Systemic Lupus Erythematosus
- Cutaneous Lupus
- (and 3 more...)
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
1000 |
Female |
18 Years and older (Adult, Older Adult) |
NCT00513591 |
Pro00000756 |
DAP Registry |
August 2007 |
June 2018 |
June 2018 |
August 8, 2007 |
June 16, 2017 |
|
- Duke University Medical Center
Durham, North Carolina, United States
|
|
| 40 |
NCT03540485 |
Not yet recruiting
New |
Safety and Efficacy of Melatonin in Patients With Multiple Progressive Primary Sclerosis |
- Sclerosis, Multiple
- Autoimmune Diseases of the Nervous System
- Nervous System Diseases
- Autoimmune Diseases
|
- Drug: Melatonin
- Other: Placebo
|
Interventional
|
Phase 1
Phase 2 |
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Rates of neurological impairment
- Rates of disability
- Number of participants with treatment-related adverse events
- (and 6 more...)
|
40 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03540485 |
MELATOMS-1
2018-001779-18 |
|
July 2018 |
July 2020 |
December 2020 |
May 30, 2018 |
May 30, 2018 |
|
- Virgen Macarena Hospital
Seville, Spain
|
|
| 41 |
NCT02775500 |
Recruiting |
Apremilast Pregnancy Exposure Registry |
- Psoriatic Arthritis
- Psoriasis
|
|
Observational
|
|
- University of California, San Diego
- Celgene
- The Organization of Teratology Information Specialists
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The number of major structural malformations identified in the children of study participants
- A pattern of major malformations identified in the children of study participants
- Pattern of minor structural malformations identified by study physical exam in the children of study participants
- (and 7 more...)
|
300 |
Female |
Child, Adult, Older Adult |
NCT02775500 |
141041 |
|
November 2014 |
February 2021 |
July 2021 |
May 17, 2016 |
March 27, 2017 |
|
- University of California, San Diego
La Jolla, California, United States
|
|
| 42 |
NCT02586831 |
Not yet recruiting |
Diabetes Islet Preservation Immune Treatment |
- Diabetes Mellitus, Type 1
- Hypoglycemia
- Autoimmune Diseases
- Diabetes Mellitus
|
- Drug: Anti-Thymocyte Globulin (ATG)
- Drug: Placebo
- Drug: Pegylated GCSF
- (and 3 more...)
|
Interventional
|
Phase 1
Phase 2 |
- Camillo Ricordi and Jay Skyler
- Diabetes Research Institute Foundation
- University of Miami
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Stimulated C-peptide AUC from a 4-hour MMTT
|
42 |
All |
18 Years to 35 Years (Adult) |
NCT02586831 |
20150856 |
DIPIT |
October 2018 |
December 2019 |
December 2021 |
October 26, 2015 |
April 5, 2018 |
|
- Diabetes Research Institute, University of Miami Miller School of Medicine
Miami, Florida, United States
|
|
| 43 |
NCT03498729 |
Recruiting |
Autoimmunity in the Pathogenesis of AF |
|
- Other: Peripheral Blood Sample
|
Observational
|
|
- Mayo Clinic
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
240 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03498729 |
16-005678
1K01HL135288-01 |
|
March 5, 2018 |
December 31, 2021 |
December 31, 2021 |
April 17, 2018 |
April 17, 2018 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
|
| 44 |
NCT02824393 |
Recruiting |
Experimental Autologous Mesenchymal Stem Cell Therapy in Treatment of Chronic Autoimmune Urticaria |
- Urticaria
- Autoimmune Diseases
- Immune System Diseases
- Skin Diseases
|
- Biological: Autologous mesenchymal stem cell
|
Interventional
|
Early Phase 1 |
- Celal Bayar University
- The Scientific and Technological Research Council of Turkey
- Acıbadem Labcell
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from baseline in weekly urticaria activity scores.
- Follow-up of the mesenchymal stem cell treatment-related side effects according to World Health Organisation (WHO) Toxicity Grading Scale for Determining The Severity of Adverse Events.
- The changes in the ratios of peripheral blood cluster of differentiation 4 (CD4) T cell subsets.
- (and 2 more...)
|
20 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02824393 |
TUBITAK-1001-215S612 |
|
March 3, 2017 |
July 15, 2018 |
June 15, 2019 |
July 6, 2016 |
June 7, 2017 |
|
- Celal Bayar University, Medical School
Manisa, Turkey
|
|
| 45 |
NCT03186794 |
Recruiting |
Aerobic Exercise in Women With Systemic Lupus Erythematosus |
- Systemic Lupus Erythematosus
- Lupus
- Autoimmune Disease
- Rheumatic Disease
|
- Other: Treadmill exercise training
|
Interventional
|
Phase 1 |
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- The primary outcome measure for our trial will be the time taken to attain the anaerobic threshold, which is a performance marker of fatigability that is unaffected by patient motivation or perception.
- Exercise training induced changes in muscle oxygenation and cardiac function and changes in questionnaire responses.
|
30 |
Female |
21 Years to 80 Years (Adult, Older Adult) |
NCT03186794 |
170111
17-CC-0111 |
|
February 22, 2018 |
December 31, 2022 |
December 31, 2022 |
June 14, 2017 |
June 5, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
| 46 |
NCT03198351 |
Recruiting |
An Observational Study on Teriflunomide-exposed Pregnancies |
|
- Drug: Teriflunomide (HMR1726)
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Rate of major structural defects in live born infants
- Proportion of major structural defects in all pregnancies
- Specific pattern of 3 or more minor structural defects in live born infants receiving the exam
- (and 4 more...)
|
325 |
Female |
16 Years and older (Child, Adult, Older Adult) |
NCT03198351 |
OBS13499
U1111-1183-8711 |
|
April 25, 2013 |
February 1, 2022 |
February 1, 2022 |
June 26, 2017 |
April 2, 2018 |
|
- Investigator
San Diego, California, United States
|
|
| 47 |
NCT01087125 |
Recruiting |
Abatacept Pregnancy Exposure Registry |
|
|
Observational
|
|
- Bristol-Myers Squibb
- University of California, San Diego
- The Organization of Teratology Information Specialists
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Major structural birth defects of newborns
- 3 or more minor structural defects
- Spontaneous abortion
- (and 4 more...)
|
240 |
Female |
Child, Adult, Older Adult |
NCT01087125 |
IM101-121 |
|
September 30, 2006 |
December 31, 2019 |
December 31, 2019 |
March 16, 2010 |
March 29, 2018 |
|
- Bristol-Myers Squibb
Princeton, New Jersey, United States
|
|
| 48 |
NCT00001979 |
Recruiting |
Immune System Related Kidney Disease |
- Glomerulonephritis
- Lupus Nephritis
- Membranous Glomerulonephritis
- (and 2 more...)
|
|
Observational
|
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Other
|
- Study of characterization of the clinical and laboratory features of these disorders and studies of natural history, as well as evaluation of responses to standard treatment.
|
99999999 |
All |
Child, Adult, Older Adult |
NCT00001979 |
920156
92-DK-0156 |
|
April 14, 1992 |
|
|
January 21, 2000 |
June 18, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 49 |
NCT00943514 |
Recruiting |
Natural History of Bronchiectasis |
- Bronchiectasis
- Cystic Fibrosis
- Autoimmune Disease
- Common Variable Immunodeficiency
|
|
Observational
|
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Document the presence of underlying associated conditions such as: Variant cystic fibrosis, Primary ciliary dyskinesia, Common variable immunodeficiency, Allergic bronchopulmonary mycosis, Autoimmune dx, Autoimmune dx, alpha-1 antitrypsin defici...
- Assessment of genetic, systemic immune, and/or epithelial surface defense mechanisms involved in airway infection susceptibility and/or in the development of bronchiectasis through the:a)Collection and storage of blood and sputumb)Use and ...
|
900 |
All |
5 Years and older (Child, Adult, Older Adult) |
NCT00943514 |
090172
09-H-0172 |
|
July 20, 2009 |
|
|
July 22, 2009 |
May 23, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 50 |
NCT00001265 |
Recruiting |
Study and Treatment of Inflammatory Muscle Diseases |
- Autoimmune Disease
- Dermatomyositis
- Inclusion Body Myositis
- (and 2 more...)
|
|
Observational
|
|
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
99999999 |
All |
16 Years and older (Child, Adult, Older Adult) |
NCT00001265 |
910196
91-AR-0196 |
|
August 8, 1991 |
|
|
November 4, 1999 |
May 21, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
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