| 1 |
NCT02896621 |
Recruiting |
Effect of Antihypertensive Agents on Diastolic Function in Patients With Sleep Apnea |
|
- Drug: Chlorthalidone plus amiloride
- Drug: Amlodipine
|
Interventional |
Phase 3 |
- Hospital de Clinicas de Porto Alegre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- E/A ratio
- Daytime sleepiness
|
53 |
All |
40 Years to 70 Years (Adult, Senior) |
NCT02896621 |
45007115.0.0000.5327
GPPG: 150274 |
DOSA-2 |
April 2015 |
April 2017 |
April 2017 |
September 12, 2016 |
September 12, 2016 |
|
- Hospital de Clinicas de Porto Alegre
Porto Alegre, RS, Brazil
|
| 2 |
NCT02710539 |
Not yet recruiting |
Once-daily Fixed Combination of Three Antihypertensive Drugs |
|
- Drug: perindopril, indapamide , amlodipine
- Drug: Tripliam (perindopril, indapamide, amlodipine)
|
Interventional |
Phase 4 |
- University of Roma La Sapienza
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Number of patients who reach target blood pressure
|
100 |
All |
Child, Adult, Senior |
NCT02710539 |
124/D/2016 |
ONE&ONLY |
April 2016 |
March 2019 |
March 2020 |
March 16, 2016 |
March 16, 2016 |
|
- University La Sapienza
Rome, Italy
|
| 3 |
NCT03479554 |
Not yet recruiting
New |
China Antihypertensive Trial in Acute Ischemic Stroke II |
|
- Other: Early antihypertensive treatment
- Other: Delayed antihypertensive treatment
|
Interventional |
Phase 3 |
- Tulane University
- Beijing Tiantan Hospital
- Soochow University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Composite outcome of death and major disability
- Recurrent stroke
- Modified Rankin Scale
- (and 4 more...)
|
4776 |
All |
40 Years and older (Adult, Senior) |
NCT03479554 |
1109725 |
CATIS-2 |
March 2018 |
June 2021 |
December 2021 |
March 27, 2018 |
March 27, 2018 |
|
- Beijing Tiantan Hospital
Beijing, Beijing, China
|
| 4 |
NCT03301025 |
Recruiting |
Pregabalin Effects on Hypotensive Anesthesia During Spine Surgery. |
|
- Drug: Pregabalin
- Drug: placebo
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Nitroglycerin consumption
- Estimated blood loss
- The number of transfused blood unites
- (and 10 more...)
|
106 |
All |
18 Years to 55 Years (Adult) |
NCT03301025 |
R/17.07.107 |
|
January 8, 2018 |
March 30, 2018 |
April 30, 2018 |
October 4, 2017 |
April 10, 2018 |
|
- Delta Hospital
Mansourah,, Dakahlia, Egypt - Mansoura University Hospital
Mansourah, Dakahlia, Egypt
|
| 5 |
NCT02672787 |
Recruiting |
A ED-based Intervention to Improve Antihypertensive Adherence |
- Hypertensive Emergency
- Hypertension
- Blood Pressure
|
- Behavioral: ED-based behavioral intervention
- Behavioral: ED usual care plus education
|
Interventional |
Not Applicable |
- Vanderbilt University
- National Heart, Lung, and Blood Institute (NHLBI)
- Vanderbilt University Medical Center
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- 1-month Blood Pressure
- 1-month Change in Adherence Measured by Assay
- 1-month Change in Adherence Measured by Patient-report
- (and 3 more...)
|
350 |
All |
21 Years to 85 Years (Adult, Senior) |
NCT02672787 |
151384
K23HL125670 |
|
February 2016 |
July 2018 |
July 2019 |
February 3, 2016 |
January 2, 2018 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
| 6 |
NCT02710552 |
Not yet recruiting |
Low-dose Combination of Three Antihypertensive Drugs |
|
- Drug: Tripliam (perindopril, indapamide, amlodipine)
- Drug: Reaptan (perindopril, amlodipine)
|
Interventional |
Phase 4 |
- University of Roma La Sapienza
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Number of patients who reach target blood pressure
|
100 |
All |
Child, Adult, Senior |
NCT02710552 |
123/D/2016 |
3D |
April 2016 |
March 2019 |
March 2020 |
March 16, 2016 |
March 17, 2016 |
|
- Sapienza University
Rome, Italy
|
| 7 |
NCT03501563 |
Recruiting
New |
Effects of Hypotensive Anesthesia on Thiol Disulphide Balance |
|
|
Observational |
|
- Recep Tayyip Erdogan University Training and Research Hospital
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Thiol / Disulfide Balance
|
80 |
All |
18 Years to 60 Years (Adult) |
NCT03501563 |
2018/63 |
|
April 5, 2018 |
September 30, 2018 |
December 30, 2018 |
April 18, 2018 |
April 19, 2018 |
|
- Recep Tayyip Erdogan University Training and Research Hospital
Rize, Turkey
|
| 8 |
NCT02893553 |
Recruiting |
The Effects of Normalizing Blood Pressure on Cerebral Blood Flow in Hypotensive Individuals With Spinal Cord Injury |
- Spinal Cord Injury
- Autonomic Dysreflexia
- Baroreceptor Integrity
- (and 7 more...)
|
- Drug: Midodrine Hydrochloride
- Drug: Pyridostigmine Bromide
- Drug: Mirabegron
- Other: Placebo
|
Interventional |
Phase 2 |
- James J. Peters Veterans Affairs Medical Center
- Kessler Foundation
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Systolic Blood Pressure
- Cerebral Blood Flow
|
50 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02893553 |
WEC-16-015 |
|
December 2016 |
December 2019 |
December 2019 |
September 8, 2016 |
January 23, 2018 |
|
- Kessler Foundation Research Center
West Orange, New Jersey, United States - James J Peters VAMC
Bronx, New York, United States
|
| 9 |
NCT03207100 |
Not yet recruiting |
Analgesia-first Minimal Sedation for Spontaneous Intracerebral Hemorrhage Early Antihypertensive Treatment |
- Early Systolic Blood Pressure Control Rate
- Hematoma Growth
- Blood Pressure Variability
- (and 2 more...)
|
- Combination Product: Analgesia-first minimal sedation
- Combination Product: Antihypertensive treatment
|
Interventional |
Not Applicable |
- Hong Yang
- Xuanwu Hospital, Beijing
- Qilu Hospital of Shandong University
- (and 13 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Systolic BP control rate at 1h post-treatment initiation
- Hematoma growth at 24 h
- BP variability
- (and 5 more...)
|
330 |
All |
18 Years and older (Adult, Senior) |
NCT03207100 |
201704004 |
|
March 1, 2018 |
February 1, 2019 |
August 1, 2019 |
July 2, 2017 |
February 28, 2018 |
|
- Xuanwu Hospital Capital Medical University
Beijing, Beijing, China - Xinqiao Hospital of Army Medical University
Chongqing, Chongqing, China - Nanfang Hospital
Guangzhou, Guangdong, China - (and 11 more...)
|
| 10 |
NCT03293147 |
Not yet recruiting |
OUTREACH: Urine Analysis and Antihypertensive Treatment |
- Hypertension
- Adherence, Medication
|
- Other: HPLC-MS/MS-guided intervention
- Other: Standard care
|
Interventional |
Not Applicable |
- University of Manchester
- British Heart Foundation
- Manchester Academic Health Science Centre
- Omron Healthcare Co., Ltd.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in Clinic systolic blood pressure
- Change in clinic systolic blood pressure
- Change in clinic diastolic blood pressure
- (and 4 more...)
|
321 |
All |
18 Years and older (Adult, Senior) |
NCT03293147 |
R120993 |
OUTREACH |
September 2018 |
December 2019 |
October 2020 |
September 26, 2017 |
September 29, 2017 |
|
- Manchester Royal Infirmary
Manchester, Greater Manchester, United Kingdom - Ninewells Hospital
Dundee, Scotland, United Kingdom - Western General Hospital
Edinburgh, Scotland, United Kingdom - (and 5 more...)
|
| 11 |
NCT03292393 |
Not yet recruiting |
Social Norms and Antihypertensive Medication Adherence |
- Hypertension
- Medication Adherence
|
- Behavioral: Financial reward
- Behavioral: Social norms
- Device: Home Blood Pressure Monitoring
- Device: Medication adherence assessment
|
Interventional |
Not Applicable |
- Florida International University
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Health Services Research
|
- Self Assessed Medication Adherence
- Self Assessed Diastolic Blood pressure (mm Hg)
- Automatic measure of Medication Adherence
- (and 3 more...)
|
40 |
All |
35 Years to 65 Years (Adult) |
NCT03292393 |
IRB-15-0196 |
|
September 2018 |
September 2019 |
March 2020 |
September 25, 2017 |
January 30, 2018 |
|
|
| 12 |
NCT03327909 |
Not yet recruiting |
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis |
- ESRD
- Hemodialysis Complication
- Blood Pressure
|
- Behavioral: TAKE vs. HOLD
|
Interventional |
Not Applicable |
- Stanford University
- Satellite Healthcare
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Intradialytic Hypotension
- Poorly controlled pre-dialysis blood pressure
- Dialysis Tolerability
|
500 |
All |
18 Years and older (Adult, Senior) |
NCT03327909 |
TAKE-HOLD |
TAKE-HOLD |
January 2018 |
January 2019 |
February 2019 |
November 1, 2017 |
November 1, 2017 |
|
|
| 13 |
NCT01912677 |
Recruiting |
Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy |
- Hypertension in Pregnancy
- Preeclampsia
|
- Drug: Nifedipine
- Drug: Labetalol
- Drug: Methyldopa
|
Interventional |
Phase 4 |
- Gynuity Health Projects
- Government Medical College, Nagpur
- Daga Memorial Women's Hospital, Nagpur, India
- (and 2 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Successful outcome
- number of hourly BP's in severe range
|
894 |
Female |
18 Years to 50 Years (Adult) |
NCT01912677 |
4000 |
|
April 2015 |
September 2017 |
September 2017 |
July 31, 2013 |
July 11, 2017 |
|
- Daga Women's Hospital
Nagpur, Maharashtra, India - Government Medical College
Nagpur, Maharashtra, India
|
| 14 |
NCT03217825 |
Recruiting |
Antihypertensive Effect of Different Doses of Rostafuroxin in Comparison With Losartan |
|
- Drug: Rostafuroxin
- Drug: Losartan
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Systolic Blood Pressure
- Diastolic blood pressure
- Trough-to-peak ratio on Systolic Blood Pressure
- Number of participants with adverse events
|
280 |
All |
25 Years to 60 Years (Adult) |
NCT03217825 |
CVT-CV-001 |
|
December 2015 |
December 2017 |
December 2017 |
July 14, 2017 |
July 14, 2017 |
|
- Cvie Therapeutics Limited
Taipei, Taiwan
|
| 15 |
NCT02890836 |
Recruiting |
Blood Pressure, Antihypertensive Treatment and Preeclampsia in Pregnant Wom-en With Pre-existing Diabetes |
|
- Drug: Antihypertensiva, mainly Metyldopa
|
Observational |
|
- Rigshospitalet, Denmark
- Odense University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Confirmed hypertension
- White coat hypertension
- Preeclampsia
- (and 6 more...)
|
500 |
Female |
18 Years and older (Adult, Senior) |
NCT02890836 |
H-15019186 |
|
February 2016 |
October 2020 |
February 2021 |
September 7, 2016 |
February 8, 2018 |
|
- Center for Pregnant Women with Diabetes
Copenhagen, Kbh Ø, Denmark
|
| 16 |
NCT02433678 |
Recruiting |
An Investigation Into The Anti-hypertensive And Potential Anti-inflammatory Actions Of Dapagliflozin |
|
- Drug: dapagliflozin
- Drug: Placebo
|
Interventional |
Phase 4 |
- University at Buffalo
- Kaleida Health
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- difference in the percent change in fasting NFκB activation (DNA binding activity) in MNC before and after dapagliflozin use
- changes in expression of inflammatory mediators
|
52 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT02433678 |
1972 |
|
November 2015 |
March 2018 |
May 2018 |
May 5, 2015 |
November 16, 2016 |
|
- ECMC Ambulatory Center, 3rd Floor
Buffalo, New York, United States
|
| 17 |
NCT03478293 |
Recruiting
New |
iStent Inject in OAG Subjects on 2 Pre-op Topical Ocular Hypotensive Medications |
- Primary Open Angle Glaucoma (POAG)
|
- Device: iStent inject surgery
|
Interventional |
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- IOP reduction at 12 and 24 months on same number or fewer medications
|
125 |
All |
18 Years and older (Adult, Senior) |
NCT03478293 |
GCF-045 |
|
February 27, 2018 |
June 30, 2021 |
September 30, 2021 |
March 27, 2018 |
March 27, 2018 |
|
- Department of Ophthalmology - UNIFESP/ Hospital São Paulo
São Paulo, Brazil
|
| 18 |
NCT03497351 |
Recruiting
New |
Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries |
|
- Drug: Nicardipine
- Drug: Urapidil
|
Interventional |
Not Applicable |
- Chinese PLA General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Diagnostic
|
|
80 |
All |
18 Years to 65 Years (Adult) |
NCT03497351 |
PLAGHAOC004 |
|
May 1, 2017 |
December 31, 2018 |
December 31, 2018 |
April 13, 2018 |
April 13, 2018 |
|
- Chinese PLA General Hospital
Beijing, Haidian, China
|
| 19 |
NCT03374553 |
Recruiting |
MINIject 636 in Patients With Open Angle Glaucoma Uncontrolled by Topical Hypotensive Medications |
|
- Device: MINIject 636 implant
|
Interventional |
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction in medicated diurnal IOP
|
25 |
All |
18 Years and older (Adult, Senior) |
NCT03374553 |
ISM05 |
|
November 25, 2017 |
November 1, 2018 |
June 30, 2020 |
December 15, 2017 |
December 15, 2017 |
|
- Maxivision Eye Hospital
Hyderabad, Telangana, India - Clinica de ojos Orillac-Calvo
Panama city, Panama
|
| 20 |
NCT03179163 |
Recruiting |
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans |
|
- Drug: Captopril Pill
- Drug: Enalapril Pill
- Drug: Hydrochlorothiazide
|
Interventional |
Phase 1
Phase 2 |
- Penn State University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- laser Doppler blood flow
- Systolic Blood Pressure
- Diastolic Blood Pressure
|
70 |
All |
40 Years to 65 Years (Adult) |
NCT03179163 |
STUDY3224
5R01HL093238
120058 |
H2SPharm |
July 20, 2016 |
August 31, 2020 |
August 31, 2020 |
June 7, 2017 |
June 7, 2017 |
|
- Pennsylvania State University
University Park, Pennsylvania, United States
|
| 21 |
NCT02853045 |
Recruiting |
Comparison of Blood Pressure Control Achieved in Antihypertensive or Generic Drugs in Moderate to Severe Hypertensive Patients |
|
- Drug: period with drug (trade name) then period with generic
- Drug: period with generic then period with drug (trade name)
|
Interventional |
Phase 4 |
- Centre Hospitalier Universitaire de Saint Etienne
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Measure of systolic blood pressure
- number of side effects
|
34 |
All |
18 Years and older (Adult, Senior) |
NCT02853045 |
1408032
2014-001404-22 |
PRINGEN |
June 11, 2015 |
April 2019 |
April 2019 |
August 2, 2016 |
July 19, 2017 |
|
- CH d'ANNONAY
Annonay, France - CH de FEURS
Feurs, France - CH de FIRMINY
Firminy, France - (and 5 more...)
|
| 22 |
NCT03453268 |
Not yet recruiting |
Impact of the Reduction in Antihypertensive Treatment on Total Mortality in Frail Subjects With Low Systolic Blood Pressure: Study in Subjects Over 80 Years Living in Nursing Homes |
|
- Other: STEP DOWN strategy
- Other: Control
|
Interventional |
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- All-cause mortality
- Blood pressure analysis
- Cause of deaths
- (and 6 more...)
|
1100 |
All |
80 Years and older (Senior) |
NCT03453268 |
P160602J
2017-A01646-47 |
RETREAT-FRAIL |
April 1, 2018 |
April 1, 2022 |
April 1, 2022 |
March 5, 2018 |
March 5, 2018 |
|
- Gériatrie - CHRU de Nancy
Nancy, France
|
| 23 |
NCT01198496 |
Recruiting |
Recurrent Stroke Prevention Clinical Outcome Study |
- Hypertension
- Stroke
- Blood Pressure
|
- Drug: Losartan, Losartan and HCTZ, Amlodipine , Spironolactone
|
Interventional |
Phase 4 |
- Biomedis International Ltd.
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- the prevention of recurrent stroke.
- The incidence of events other than stroke
|
5000 |
All |
50 Years to 85 Years (Adult, Senior) |
NCT01198496 |
RESPECT 1
UMIN000002851 |
RESPECTS |
October 2010 |
December 2017 |
December 2019 |
September 10, 2010 |
July 31, 2012 |
|
- Jichi Medical Univercity
Shimotsuke, Tochigi, Japan
|
| 24 |
NCT02893358 |
Not yet recruiting |
Antihypertensive Treatment in Masked Hypertension for Target Organ Protection |
|
- Drug: Allisartan Isoproxil
- Drug: Placebo
|
Interventional |
Phase 4 |
- Yan Li
- Shanghai Institute of Hypertension
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Improvement rate of target organ damage (left ventricular hypertrophy, large arterial stiffness and microalbuminuria)
- 24h ambulatory blood pressure
- electrocardiogram
- (and 3 more...)
|
300 |
All |
30 Years to 70 Years (Adult, Senior) |
NCT02893358 |
ANTI-MASK20160830 |
ANTI-MASK |
November 2016 |
November 2018 |
|
September 8, 2016 |
September 8, 2016 |
|
- Ruijin Hospital
Shanghai, Shanghai, China
|
| 25 |
NCT03242785 |
Recruiting |
Impact of Self-monitoring of Blood Pressure and Self-titration of Medication in the Control of Hypertension (ADAMPA) |
- Hypertension
- Adjustment
- Adherence, Medication
|
- Other: Self-monitoring/Self-titration
|
Interventional |
Not Applicable |
- Fundación para la Investigación del Hospital Clínico de Valencia
- Spanish Clinical Research Network - CAIBER
- Carlos III Health Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Mean systolic blood pressure (SBP).
- Mean systolic blood pressure at 6 and 24 months
- Mean diastolic blood pressure (DBP) at 6 and 24 months
- (and 5 more...)
|
458 |
All |
40 Years and older (Adult, Senior) |
NCT03242785 |
ADAMPA
2016-003986-25 |
ADAMPA |
July 21, 2017 |
December 2018 |
December 2019 |
August 8, 2017 |
August 8, 2017 |
|
- Departamento de Salud Valencia Clínico Malvarrosa
Valencia, Spain
|
| 26 |
NCT03476616 |
Not yet recruiting
New |
Antihypertensive Pharmacological Therapy With Mineralocorticoid Receptor Antagonists in Obese Hypertensive Patients |
|
- Drug: Eplerenone (-based therapy) arm
- Drug: Valsartan (-based therapy) arm
|
Interventional |
Phase 4 |
- Hippocration General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Difference in change of ABPM from baseline, in the eplerenone arm versus the valsartan arm as monotherapy at 8 weeks, as combined dual treatment with amlodipine at 16 weeks and as combined triple treatment with amlodipine and indapamide at 24 weeks.
- Difference in change of office BP from baseline, in the eplerenone arm versus the valsartan arm as monotherapy at 8 weeks, as combined dual treatment with amlodipine at 16 weeks and as combined triple treatment with amlodipine and indapamide at 24 weeks.
|
330 |
All |
30 Years to 75 Years (Adult, Senior) |
NCT03476616 |
|
HEVRO |
May 1, 2018 |
June 1, 2020 |
June 1, 2020 |
March 26, 2018 |
March 27, 2018 |
|
- Hypertension Unit, First Cardiology Clinic, Hippocration General Hospital, University of Athens, Athens, Greece
Athens, Greece
|
| 27 |
NCT03401580 |
Not yet recruiting |
Efficacy of Fixed-doses of Antihypertensive and Statin Drugs |
|
- Drug: Viena II 160/10
- Drug: Viena II 190/10
- Drug: Viena II 160/12
- Drug: Viena II 190/12
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Reduction of systemic blood pressure measured between the first visit and last visit
- Percentage of reduction of LDL-c between the first visit and the last visit.
- Incidence and severity of adverse events recorded during the study
|
276 |
All |
18 Years to 65 Years (Adult) |
NCT03401580 |
EMS0317 |
|
January 2019 |
July 2019 |
September 2019 |
January 17, 2018 |
January 17, 2018 |
|
|
| 28 |
NCT02868502 |
Not yet recruiting |
Different Glaucoma Treatments Effect on Intraocular Pressure Fluctuation With Postural Change in Eyes With Open-angle Glaucoma |
|
- Device: Goldmann tonometer
- Device: Pneumatonometer
- Device: Tonopen XL
- Device: ICare rebound tonometer
|
Observational |
|
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Measurements of Intra Ocular Pressure Fluctuation with Postural Change in Eyes with Open-angle Glaucoma and Ocular Hypertension, compared to healthy subjects
|
150 |
All |
18 Years to 95 Years (Adult, Senior) |
NCT02868502 |
MMC-0026-16 |
|
September 2016 |
August 2017 |
August 2017 |
August 16, 2016 |
August 16, 2016 |
|
|
| 29 |
NCT02531490 |
Recruiting |
Early Vascular Adjustments During Hypertensive Pregnancy |
- Hypertension, Pregnancy-Induced
- Pre-Eclampsia
|
- Drug: Labetalol
- Drug: Nifedipine
- Drug: Methyldopa
|
Interventional |
Phase 4 |
- Maastricht University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- number of patients with severe gestational hypertension
- number of patients with preeclampsia
- the pattern of change of the hemodynamic profile, measured by the ratio of mean arterial pressure and heart rate.
- (and 11 more...)
|
368 |
Female |
18 Years to 50 Years (Adult) |
NCT02531490 |
METC152017 |
EVA |
January 1, 2015 |
February 2020 |
April 2020 |
August 24, 2015 |
April 10, 2018 |
|
- Maastricht UMC
Maastricht, Netherlands
|
| 30 |
NCT03292900 |
Not yet recruiting |
Association Between Genetic Algorithm to Predict Hypertension Therapy and Response to Treatment |
|
|
Observational |
|
- Geneticure, LLC
- Fairview Health Services
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Level of Blood Pressure Control
- Number of medications needed to obtain blood pressure control
- Time to blood pressure control
- (and 4 more...)
|
2000 |
All |
30 Years to 80 Years (Adult, Senior) |
NCT03292900 |
Geneticure600 |
|
March 1, 2018 |
January 31, 2019 |
February 28, 2019 |
September 26, 2017 |
February 19, 2018 |
|
- Fairview Clinic - New Brighton
New Brighton, Minnesota, United States
|
| 31 |
NCT02016768 |
Recruiting |
Decompressive Cervical Surgery and Hypertension |
- Myelopathy, Compressive
- Hypertension
|
- Procedure: decompressive cervical surgery
|
Observational |
|
- Peking University First Hospital
- Peking University
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change from baseline in the systolic blood pressure(SBP) measured by 24-hour Ambulatory Blood Pressure Monitoring(ABPM) on 1st month and 3th month post-operation.
|
50 |
All |
18 Years to 84 Years (Adult, Senior) |
NCT02016768 |
PUCRP201304 |
|
January 2014 |
December 2016 |
December 2016 |
December 20, 2013 |
October 3, 2016 |
|
- Hong LIu
Beijing, Beijing, China
|
| 32 |
NCT03431077 |
Recruiting |
A Study of LJPC‑501 in Pediatric Patients With Hypotension |
- Catecholamine-resistant Hypotension (CRH)
- Distributive Shock
- High Output Shock
- Sepsis
|
|
Interventional |
Phase 2 |
- La Jolla Pharmaceutical Company
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effect of LJPC-501 on mean arterial pressure (MAP)
- Effect of LJPC-501 on sum norepinephrine (NE) equivalent dose
- Effect of LJPC-501 on the incidence of treatment-emergent adverse events
- (and 10 more...)
|
30 |
All |
2 Years to 17 Years (Child) |
NCT03431077 |
LJ501-CRH02 |
|
February 12, 2018 |
June 30, 2019 |
July 31, 2019 |
February 13, 2018 |
February 13, 2018 |
|
- Investigational Site
Charlotte, North Carolina, United States
|
| 33 |
NCT03156634 |
Recruiting |
A Pilot Study of the Impact of the Patient Activated Learning System (PALS) on Knowledge Acquisition, Recall, and Decision Making |
|
|
Interventional |
Not Applicable |
- Weill Medical College of Cornell University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Knowledge acquisition
- Recall
- User experience
- Decision making
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT03156634 |
1610017672 |
|
April 15, 2017 |
December 31, 2017 |
December 31, 2018 |
May 17, 2017 |
May 17, 2017 |
|
- Weill Cornell Internal Medicine Associates
New York, New York, United States
|
| 34 |
NCT02752217 |
Recruiting |
Effectiveness of Inspiratory Muscle Training With Slow Breathing in Elderly With ISH |
|
- Other: Inspiratory Muscle Training
- Other: Control
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change from baseline in Maximal inspiratory pressure (MIP)
- Lung capacity
- Exercise capacity
- (and 2 more...)
|
32 |
All |
60 Years to 80 Years (Adult, Senior) |
NCT02752217 |
HE 581469 |
|
March 2016 |
July 2018 |
September 2018 |
April 26, 2016 |
April 26, 2016 |
|
- Faculty of Associated Medical Sciences
Na Muang, Khon Kaen, Thailand
|
| 35 |
NCT03503773 |
Not yet recruiting
New |
The TARGET BP OFF-MED Trial |
- Hypertension
- Hypertension,Essential
|
- Drug: Alcohol
- Other: Sham control
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in Systolic Ambulatory Blood Pressure
- Changes in Ambulatory Blood Pressure
- Changes in Office Blood Pressure
- Responders to target Blood Pressure
|
400 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03503773 |
CR0014 |
|
May 2018 |
June 2019 |
September 2021 |
April 20, 2018 |
April 20, 2018 |
|
|
| 36 |
NCT02922023 |
Recruiting |
Management of Uncontrolled Hypertension (HTN) |
|
- Device: Ambulatory blood pressure monitor (ABPM)
- Other: Chronotherapy
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in blood pressure
- Amount of subjects from each group that achieved blood pressure goal
|
25 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT02922023 |
IRB201601421 |
|
January 2017 |
August 2018 |
November 2018 |
October 3, 2016 |
September 25, 2017 |
|
- University of Florida
Gainesville, Florida, United States
|
| 37 |
NCT03231293 |
Recruiting |
Fimasartan Blood Pressure Lowering After Acute Stroke |
- Hypertension
- Ischemic Stroke
- Transient Ischemic Attack
|
|
Observational |
|
- Boryung Pharmaceutical Co., Ltd
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Blood pressure control rate(<140/90 mmHg)
- Blood pressure changes
- mRS changes
- (and 7 more...)
|
1032 |
All |
19 Years and older (Adult, Senior) |
NCT03231293 |
BR-FMS-OS-401 |
FABULOUS |
July 28, 2016 |
May 30, 2018 |
December 30, 2019 |
July 27, 2017 |
July 27, 2017 |
|
- Severance Hospital
Seodaemun-gu, Seoul, Korea, Republic of
|
| 38 |
NCT02299414 |
Recruiting |
Chronic Hypertension and Pregnancy (CHAP) Project |
|
- Drug: Anti-hypertensive therapy
- Other: No anti-hypertensive therapy (unless BP is severe)
|
Interventional |
Phase 4 |
- University of Alabama at Birmingham
- Columbia University
- Drexel University College of Medicine
- (and 52 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Composite adverse perinatal outcome
- Small for Gestational Age
- Composite of maternal death or severe cardiovascular morbidity
- (and 2 more...)
|
4700 |
Female |
12 Years and older (Child, Adult, Senior) |
NCT02299414 |
1U01HL119242-01
U01HL119242-01 |
CHAP |
September 2016 |
December 2019 |
May 2020 |
November 24, 2014 |
March 16, 2018 |
|
- University of Alabama at Birmingham, Clinical Coordinating Center
Birmingham, Alabama, United States - University of Alabama at Birmingham, Data Coordinating Center
Birmingham, Alabama, United States - University of California, San Diego
San Diego, California, United States - (and 57 more...)
|
| 39 |
NCT02913794 |
Recruiting |
Fimasartan and Rosuvastatin for Hypertension and Dyslipidemia Control |
- Cardiovascular Diseases
- Hyperlipidemias
|
|
Observational |
|
- Boryung Pharmaceutical Co., Ltd
|
Industry |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- Co-relation between blood pressure and dyslipidemia
|
1056 |
All |
19 Years and older (Adult, Senior) |
NCT02913794 |
BR-FMS-OS-402 |
FIMARO |
October 11, 2016 |
March 30, 2018 |
March 30, 2018 |
September 26, 2016 |
July 26, 2017 |
|
- Severance Hospital
Seoul, Korea, Republic of
|
| 40 |
NCT03294070 |
Not yet recruiting |
Fimasartan Plus Amlodipine on Hemodynamic Parameters and Arterial Stiffness in Patients With Hypertension |
|
- Combination Product: Fimasartan plus amlodipine besylate
|
Interventional |
Phase 4 |
- Centro Universitario de Ciencias de la Salud, Mexico
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction of pulse wave velocity
- Central Aortic Pressure
- Central Pulse Pressure
- Rising Index
|
53 |
All |
18 Years to 65 Years (Adult) |
NCT03294070 |
INTEC-1 |
|
September 2017 |
March 2018 |
August 2018 |
September 26, 2017 |
September 26, 2017 |
|
|
| 41 |
NCT02439749 |
Recruiting |
SPYRAL HTN-OFF MED Study |
- Hypertension
- Vascular Diseases
- Cardiovascular Diseases
|
- Device: Symplicity Spyral™ multi-electrode renal denervation system
- Procedure: Sham Procedure
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Acute and chronic safety by evaluating incidence of Major Adverse Events
- Change in systolic blood pressure as measured by 24-hour Ambulatory Blood Pressure Monitoring (ABPM)
- Change in office systolic blood pressure
- (and 3 more...)
|
170 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT02439749 |
SPYRAL HTN-OFF MED |
|
June 2015 |
July 2018 |
July 2021 |
May 12, 2015 |
April 13, 2018 |
|
- Kaiser Permanente LA Medical Center
Los Angeles, California, United States - Stanford Hospital and Clinics
Stanford, California, United States - Baptist Medical Center Jacksonville
Jacksonville, Florida, United States - (and 26 more...)
|
| 42 |
NCT03231982 |
Recruiting |
Study to Confirm the Efficacy and Safety of Fixed-dose Combinations of Amlodipine and Candesartan |
|
- Drug: Group I
- Drug: Group II
|
Interventional |
Phase 4 |
- CJ HealthCare Corporation
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in sitting Systolic Blood Pressure(siSBP) from baseline after 8 weeks of treatment
- Change in siSBP from baseline after 4 weeks of treatment
- Change in siDBP from baseline after 4 and 8 weeks of treatment
- Proportion of subjects with siDBP < 90 mmHg and siSBP <140 mmHg after 8 weeks of treatment
|
210 |
All |
19 Years to 75 Years (Adult, Senior) |
NCT03231982 |
CJ_CCA_401 |
MACH |
April 17, 2017 |
October 31, 2018 |
December 31, 2018 |
July 27, 2017 |
July 27, 2017 |
|
- Yonsei University Severance Cardiovascular Hospital
Seoul, Korea, Republic of
|
| 43 |
NCT02449811 |
Recruiting |
RAS Peptide Profiles in Patients With Arterial Hypertension |
|
- Drug: Perindopril
- Drug: Olmesartan
- Drug: Amlodipine
- Drug: Hydrochlorothiazide
|
Observational |
|
- University Hospital Inselspital, Berne
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- RAS peptide profiles
- Composite measure of Non-invasive hemodynamic parameters
- Plasma renin activity and aldosterone concentration
- Antihypertensive drug concentrations
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT02449811 |
EKNZ 2015-081 |
|
April 2015 |
November 2017 |
February 2018 |
May 20, 2015 |
November 6, 2017 |
|
- University Hospital
Basel, Switzerland
|
| 44 |
NCT03284853 |
Recruiting |
Safety and Efficacy Study of PG324 (Netarsudil/Latanoprost 0.02% / 0.005%) Ophthalmic Solution Compared to GANFORT® Ophthalmic Solution in Open Angle Glaucoma or Ocular Hypertension |
- Open Angle Glaucoma
- Ocular Hypertension
|
- Drug: Netarsudil/Latanoprost 0.02%/0.005%
- Drug: GANFORT®
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Mean diurnal Intraocular Pressure by Goldmann Applanation Tonometry
- Assessment of anterior segment tissues by slit lamp biomicroscopy
- Assessment of posterior segment tissues by dilated ophthalmoscopy
- (and 4 more...)
|
472 |
All |
18 Years and older (Adult, Senior) |
NCT03284853 |
PG324-CS303 |
|
September 5, 2017 |
April 2019 |
April 2019 |
September 15, 2017 |
April 17, 2018 |
|
- State Hospital - University Medical Center Academical Department of Ophthalmology
Graz, Austria - Albertgasse 39/10+11
Vienna, Austria - UZ Leuven Sint Rafael
Leuven, Belgium - (and 44 more...)
|
| 45 |
NCT03310580 |
Recruiting |
Study of Netarsudil Ophthalmic Solution in Japanese/Japanese-American Subjects With Open-angle Glaucoma or Ocular Hypertension |
- Primary Open Angle Glaucoma or Ocular Hypertension
|
- Drug: Netarsudil Ophthalmic Solution 0.02%
- Drug: Netarsudil Ophthalmic Solution 0.04%
- Drug: Netarsudil Ophthalmic Solution Placebo
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Mean diurnal IOP within a treatment by Goldman Applanation
- Mean diurnal IOP at Days 8 and 15
- Mean change from baseline in mean diurnal IOP at each post-treatment visit
- (and 5 more...)
|
180 |
All |
18 Years and older (Adult, Senior) |
NCT03310580 |
AR-13324-CS205 |
|
November 15, 2017 |
October 2018 |
October 2018 |
October 16, 2017 |
April 19, 2018 |
|
- Arizona Eye Center
Chandler, Arizona, United States - Arizona Glaucoma Specialists
Phoenix, Arizona, United States - Havana Research Institute
Burbank, California, United States - (and 33 more...)
|
| 46 |
NCT02163044 |
Recruiting |
The Hellenic Postprandial Lipemia Study (HPLS) |
- Coronary Heart Disease
- Dyslipidemia
|
|
Observational |
|
- Hellenic College of Treatment of Atherosclerosis
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Change in CRP levels
- Change in exaggerated postprandial lipemia
- Change in Lipotest meal values
- Number of major adverse cardiovascular events
|
1200 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02163044 |
2014-HPLS-IIS |
HPLS |
September 2014 |
June 2018 |
June 2018 |
June 13, 2014 |
March 7, 2018 |
|
- Onassion Cardiology Hospital
Athens, Greece
|
| 47 |
NCT03348878 |
Not yet recruiting |
Descriptive Study of Drug Compliance in Uncontrolled Hypertensive Patients |
- Uncontrolled Hypertension
|
- Other: assessment of drug compliance
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- individual pattern of drug compliance
- Percentage of Prescribed Dosing Days with Correct Intake
- Percentage of Prescribed Dose Taken
- (and 2 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03348878 |
69HCL17_0325 |
THERMO-HTA |
November 2017 |
August 2020 |
August 2020 |
November 21, 2017 |
November 21, 2017 |
|
|
| 48 |
NCT02963181 |
Recruiting |
Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension |
- Hypotension, Orthostatic
- Hypertension
- Autonomic Nervous System Diseases
|
- Drug: Yohimbine
- Drug: Melatonin
|
Interventional |
Early Phase 1 |
- Lawson Health Research Institute
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Investigation into the integrity of post-ganglionic sympathetic nerves in idiopathic NOH
- Effects of melatonin on supine hypertension in persons with neurogenic orthostatic hypotension
- Effects of melatonin on supine hypertension in patients with neurogenic orthostatic hypotension
- (and 6 more...)
|
60 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02963181 |
010788 |
|
March 1, 2018 |
August 2019 |
August 2019 |
November 15, 2016 |
March 9, 2018 |
|
- University Hospital
London, Ontario, Canada
|
| 49 |
NCT03249285 |
Recruiting |
Pharmacogenomics of Hypertension Personalized Medicine (PGX-HT) |
|
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- SBP (Systolic blood pressure) and DBP (Diastolic blood pressure) response
- Profiles implementation
|
300 |
All |
25 Years to 60 Years (Adult) |
NCT03249285 |
udraCT NUMBER: 2015-001888-39 |
PGX-HT |
March 2016 |
March 2018 |
November 2018 |
August 15, 2017 |
August 15, 2017 |
|
- Azienda Sanitaria 6
Livorno, Italy - San Raffaele Hospital
Milan, Italy - Azienda Ospedaliero - Universitaria S. Maria della Misericordia
Udine, Italy
|
| 50 |
NCT02472028 |
Recruiting |
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals |
- Cerebrovascular Disorders
|
- Other: blood pressure lowering algorithm
- Other: usual strategy
|
Interventional |
Phase 4 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- The main criterion is based on the quantitative assessment of White Matter Lesions (WML) volumes at the beginning and at the end of the study for each patient and each arm of the trial. The WML volume from the final MRI is compared to that of the initial
- Imaging criteria : changes in the number of large or confluent WML
- Imaging criteria : changes in the volume of WML depending on their location (periventricular and deep white matter)
- (and 8 more...)
|
820 |
All |
60 Years to 88 Years (Adult, Senior) |
NCT02472028 |
P100153
2014 A00265-42 |
LEOPOLD |
September 2015 |
January 2019 |
January 2019 |
June 15, 2015 |
July 1, 2016 |
|
- Memory for Research and Resources Center / Neuroscience pole
Bordeaux, Pellegrin Hospital Group, France - Memory Resources Centre and South of Ile de France Search - Broca Hospital
Paris, France
|
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