43672 studies found for:    "Physiological Effects of Drugs"
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Rank Status Study
1 Active, not recruiting Immunogenicity, Safety, Tolerability of a Plant-made H5 Virus-like-particle (VLP) Influenza Vaccine.
Conditions: Virus Diseases;   RNA Virus Infections;   Respiratory Tract Diseases;   Respiratory Tract Infections
Interventions: Biological: Low dose of H5 VLP vaccine + Alhydrogel;   Biological: Med dose of H5 VLP vaccine + Alhydrogel;   Biological: High dose of H5 VLP vaccine + Alhydrogel;   Biological: Low dose of H5 VLP vaccine + GLA-SE;   Biological: High dose of H5 VLP vaccine + GLA-SE;   Biological: Placebo comparator: Placebo
2 Completed The Effect of Caffeine in Elderly Citizen Following Eight Hour Abstinence From Caffeine Containing Drinks & Foods
Conditions: Healthy;   Elderly
Intervention: Drug: Caffeine
3 Unknown  KEEPS Cognitive and Affective Study
Conditions: Perimenopause;   Coronary Disease;   Estrogen Replacement Therapy;   Hormone Replacement Therapy
Interventions: Drug: oral conjugated equine estrogens;   Drug: transdermal estradiol;   Drug: micronized progesterone;   Other: Placebo
4 Completed Comparing Subsartorial Saphenous Nerve Blocks With and Without Dexamethasone for Anterior Cruciate Ligament Reconstruction
Conditions: Anterior Cruciate Ligament Reconstruction;   Regional Anesthesia, Saphenous Nerve Block
Interventions: Drug: Bupivacaine Only;   Drug: Bupivacaine with 1 mg of Dexamethasone;   Drug: Bupivacaine with 4 mg of Dexamethasone
5 Recruiting Phase I Study of a Dendritic Cell Vaccine for Patients With Either Newly Diagnosed or Recurrent Glioblastoma
Conditions: Glioblastoma;   Glioblastoma Multiforme;   Glioma;   Astrocytoma;   Brain Tumor
Interventions: Biological: Dendritic cell vaccination, in addition to standard temozolomide chemotherapy and involved field radiation therapy;   Biological: Dendritic cell vaccination, with optional bevacizumab treatment for patients previously treated with bevacizumab
6 Recruiting The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach
Conditions: Granulomatosis With Polyangiitis;   Wegener Granulomatosis;   Vasculitis
Interventions: Drug: 5 mg prednisone;   Drug: 0 mg prednisone
7 Completed Combined Intracameral Lidocaine for Manual Small Incision Cataract Surgery Under Topical Anesthesia
Condition: Cataract
Interventions: Procedure: MSICS under topical anesthesia with intracameral lidocaine;   Procedure: MSICS under topical anesthesia with intracameral balanced salt solution.
8 Recruiting A Study of Brentuximab Vedotin in Patients With Relapsed or Refractory Hodgkin Lymphoma
Condition: Hodgkin Lymphoma
Intervention: Drug: Brentuximab vedotin
9 Completed New Individualized Therapy Trial for Metastatic Colorectal Cancer
Conditions: Colorectal Neoplasm;   Colorectal Cancer
Interventions: Drug: Imatinib mesylate followed by a combination of imatinib mesylate & panitumumab;   Drug: Standard-of-care treatment with panitumumab
10 Completed
Has Results
A Study to Assess the Safety, Tolerability and Glucose-Lowering Efficacy of MK-0893 in Participants With Type 2 Diabetes Mellitus (MK-0893-005)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: MK-0893;   Drug: Metformin;   Drug: Placebo
11 Recruiting Intra-Peritoneal Local Anaesthesia After Cytoreductive Surgery
Condition: Pain
Interventions: Drug: Ropivacaine;   Drug: Saline
12 Completed Local Infiltration Analgesia After Abdominal Hysterectomy
Condition: Pain
Interventions: Drug: ropivacaine, ketorelac and epinephrine;   Drug: Placebo
13 Completed Caffeine for Motor Manifestations of Parkinson's Disease
Condition: Parkinson's Disease
Intervention: Drug: Caffeine alkaloid
14 Completed Effect of Magnesium on the Recovery Time of Neuromuscular Blockade With Sugammadex
Condition: Neuromuscular Blockade
Interventions: Drug: Magnesium Sulfate;   Drug: Saline
15 Completed Study to Evaluate the Safety and Efficacy of the Addition of MK-3102 Compared With the Addition of Sitagliptin in Subjects With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-3102-026)
Condition: Type 2 Diabetes
Interventions: Drug: MK-3102;   Drug: Sitagliptin;   Drug: Placebo to MK-3102;   Drug: Placebo to Sitagliptin;   Drug: Open-label Metformin;   Drug: Open-label Glimepiride
16 Active, not recruiting An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker Analysis
Condition: Oestrogen Receptor Positive Advanced Breast Cancer
Interventions: Drug: RAD001;   Drug: Exemestane
17 Active, not recruiting Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013)
Conditions: Paroxysmal Nocturnal Hemoglobinuria;   Hemoglobinuria;   Hemoglobinuria, Paroxysmal;   Proteinuria;   Urination Disorders;   Thrombosis;   Bone Marrow Failure;   Aplastic Anemia,;   Anemia, Hemolytic
Interventions: Drug: Levamisole+cyclosporin A+Glucocorticoids;   Drug: cyclosporin A+Glucocorticoids;   Drug: Glucocorticoids
18 Completed Pregabalin for the Treatment of Pain After Posterior Spinal Fusions
Condition: Lumbar Spinal Fusions
Interventions: Drug: Pregabalin 150 mg;   Drug: Placebo
19 Completed A Study to Determine the Efficacy and Safety of Halobetasol Propionate Lotion 0.05% in Subjects With Plaque Psoriasis
Conditions: Psoriasis;   Plaque Psoriasis
Interventions: Drug: Halobetasol Propionate Lotion 0.05%;   Drug: Placebo
20 Recruiting Liraglutide as add-on to Insulin in Type 1 Diabetes
Conditions: Diabetes;   Diabetes Mellitus, Type 1
Interventions: Drug: Liraglutide;   Drug: Placebo

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Indicates status has not been verified in more than two years