53225 studies found for:    "Physiological Effects of Drugs"
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1 Active, not recruiting Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013)
Conditions: Paroxysmal Nocturnal Hemoglobinuria;   Hemoglobinuria;   Hemoglobinuria, Paroxysmal;   Proteinuria;   Urination Disorders;   Thrombosis;   Bone Marrow Failure;   Aplastic Anemia,;   Anemia, Hemolytic
Interventions: Drug: Levamisole+cyclosporin A+Glucocorticoids;   Drug: cyclosporin A+Glucocorticoids;   Drug: Glucocorticoids
2 Completed Liraglutide as add-on to Insulin in Type 1 Diabetes
Conditions: Diabetes;   Diabetes Mellitus, Type 1
Interventions: Drug: Liraglutide;   Drug: Placebo
3 Completed Pregabalin for the Treatment of Pain After Posterior Spinal Fusions
Condition: Lumbar Spinal Fusions
Interventions: Drug: Pregabalin 150 mg;   Drug: Placebo
4 Completed A Study to Determine the Efficacy and Safety of Halobetasol Propionate Lotion 0.05% in Subjects With Plaque Psoriasis
Conditions: Psoriasis;   Plaque Psoriasis
Interventions: Drug: Halobetasol Propionate Lotion 0.05%;   Drug: Placebo
5 Recruiting A Study of Vitamin C in the Treatment of Liver Cancer to Determine if it is Safe and Effective
Conditions: Metastatic Hepatocellular Carcinoma;   Advanced Liver Cancer
Interventions: Drug: Ascorbic Acid + Sorafenib;   Drug: Sorafenib alone
6 Active, not recruiting An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker Analysis
Condition: Oestrogen Receptor Positive Advanced Breast Cancer
Interventions: Drug: RAD001;   Drug: Exemestane
7 Recruiting Potentiation of Quetiapine Treatment With Lithium or Aripiprazole in Bipolar 1 Nonresponders Patients
Condition: Bipolar I Disorder
Interventions: Drug: Lithium;   Drug: Aripiprazole
8 Active, not recruiting Safety, Tolerability and Immunogenicity of a Plant-made H7 Virus-like Particle (VLP) Influenza Vaccine in Adults.
Conditions: Virus Diseases;   RNA Virus Infections;   Respiratory Tract Diseases;   Respiratory Tract Infections
Interventions: Biological: Low dose of H7 VLP vaccine + Alhydrogel;   Biological: Med dose of H7 VLP vaccine + Alhydrogel;   Biological: High dose of H7 VLP vaccine + Alhydrogel;   Biological: High dose of H7 VLP vaccine;   Biological: Placebo
9 Recruiting Combination Chemotherapy or 90-Yttrium Ibritumomab Tiuxetan and Combination Chemotherapy Before Stem Cell Transplant in Treating Patients With Relapsed Diffuse Large B-cell Non-Hodgkin Lymphoma
Conditions: Recurrent Diffuse Large B-Cell Lymphoma;   Refractory Diffuse Large B-Cell Lymphoma
Interventions: Radiation: Yttrium Y 90 Ibritumomab tiuxetan;   Drug: Carmustine;   Drug: Etoposide;   Drug: Cytarabine;   Drug: Melphalan;   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Biological: Rituximab;   Procedure: Peripheral Blood Stem Cell Transplantation;   Other: Laboratory Biomarker Analysis
10 Completed A Comparison of PR Oxycodone/Naloxone and PR Oxycodone After Cardiac Surgery
Conditions: Postoperative Pain;   Opioid Related Disorders
Interventions: Drug: Oxycodone;   Drug: Prolonged-release oxycodone/naloxone
11 Completed
Has Results
Modulation of Breast Cancer Risk Biomarkers by High Dose Vitamin D
Condition: Breast Cancer
Intervention: Drug: vitamin D3
12 Completed The Safety and Tolerability of Budesonide Foam in Subjects With Active Ulcerative Proctitis or Proctosigmoiditis
Conditions: Proctitis;   Proctosigmoiditis
Intervention: Drug: Budesonide Foam
13 Completed Study in Infants With Infantile Hemangioma to Compare Propranolol Gel to Placebo
Condition: Infantile Hemangioma
Interventions: Drug: propranolol gel;   Drug: Placebo
14 Enrolling by invitation Effect of Alendronate on Bone in People With Chronic Spinal Cord Injury Previously Treated With Teriparatide
Conditions: Spinal Cord Injury;   Bone Loss;   Osteoporosis
Interventions: Drug: Alendronate;   Dietary Supplement: Calcium;   Dietary Supplement: Vitamin D
15 Recruiting Resveratrol and First-degree Relatives of Type 2 Diabetic Patients
Condition: Pre-diabetes
Interventions: Dietary Supplement: placebo;   Dietary Supplement: resveratrol
16 Completed University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)
Conditions: Nonalcoholic Steatohepatitis;   Nonalcoholic Fatty Liver Disease;   Type 2 Diabetes Mellitus
Interventions: Drug: Pioglitazone;   Drug: Placebo
17 Recruiting Oral Testosterone for the Treatment of Hypogonadism in Males
Condition: Hypogonadism
Intervention: Drug: TSX-002
18 Active, not recruiting Study of Vorinostat (MK-0683) an HDAC Inhibitor, or Placebo in Combination With Bortezomib in Patients With Multiple Myeloma (MK-0683-088 AMN)
Condition: Multiple Myeloma
Interventions: Drug: vorinostat;   Drug: bortezomib;   Drug: placebo to vorinostat
19 Completed
Has Results
A Study to Assess the Safety, Tolerability and Glucose-Lowering Efficacy of MK-0893 in Participants With Type 2 Diabetes Mellitus (MK-0893-005)
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: MK-0893;   Drug: Metformin;   Drug: Placebo
20 Active, not recruiting Immunogenicity, Safety, Tolerability of a Plant-made H5 Virus-like-particle (VLP) Influenza Vaccine.
Conditions: Virus Diseases;   RNA Virus Infections;   Respiratory Tract Diseases;   Respiratory Tract Infections
Interventions: Biological: Low dose of H5 VLP vaccine + Alhydrogel;   Biological: Med dose of H5 VLP vaccine + Alhydrogel;   Biological: High dose of H5 VLP vaccine + Alhydrogel;   Biological: Low dose of H5 VLP vaccine + GLA-SE;   Biological: High dose of H5 VLP vaccine + GLA-SE;   Biological: Placebo comparator: Placebo

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Indicates status has not been verified in more than two years