Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
615 studies found for:    "Narcotic Antagonists"
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Rank Status Study
1 Completed The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism
Condition: Opiate Addiction
Interventions: Drug: Naltrexone;   Drug: Clonidine;   Drug: Lorazepam
2 Completed An Open-Label Evaluation of the Independent Effects of Coadministration of a High-Fat Meal and Naltrexone Blockade on the Pharmacokinetic Profile of Dilaudid OROS (Hydromorphone HCI) 16mg
Condition: Analgesia
Intervention: Drug: Hydromorphone HCL 16mg; Dilaudid SR 16mg; Naltrexone (opioid antagonist) 50mg.
3 Completed Methylnaltrexone for Opioid-induced Constipation in Cancer Patients
Conditions: Neoplasms;   Constipation;   Opioid-Related Disorders
Intervention: Drug: Methylnaltrexone bromide
4 Active, not recruiting Cardiovascular Outcomes Study of Naltrexone SR/Bupropion SR in Overweight and Obese Subjects With Cardiovascular Risk Factors (The Light Study)
Conditions: Obesity;   Overweight
Interventions: Drug: NB32;   Drug: PBO;   Behavioral: Weight Management Program
5 Recruiting Comparison of Two Naloxone Infusion Rates on the Postoperative Recovery of Patients Undergoing Spine Fusion Surgery
Conditions: Pain, Postoperative;   Postoperative Nausea and Vomiting;   Scoliosis
Intervention: Drug: Naloxone
6 Terminated Opioid Agonist and Antagonist Effects on Opioid Dependence
Condition: Opioid-Related Disorders
Interventions: Drug: Methadone;   Drug: Full opioid agonist;   Drug: Partial opioid agonist;   Drug: Opioid antagonist
7 Unknown  Buprenorphine's Dose Response Curve
Condition: Opioid-related Disorders
Interventions: Drug: Buprenorphine;   Drug: Morphine;   Drug: Placebo
8 Completed Naloxone and Intravenous Methylnaltrexone Effects on Bladder Function
Condition: Healthy Males
Interventions: Drug: Naloxone;   Drug: IV Methylnaltrexone (MNTX);   Drug: Placebo
9 Terminated Naltrexone in Borderline Personality Disorder
Condition: Borderline Personality Disorder
Intervention: Drug: Naltrexone
10 Active, not recruiting Investigation of Naltrexone for Pathological Gambling
Condition: Pathological Gambling
Interventions: Drug: Naltrexone;   Other: Placebo
11 Terminated Naltrexone Implants as Relapse Prevention
Condition: Opioid Dependency
Intervention: Drug: Implantation of naltrexone implants
12 Recruiting Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients
Condition: Opioid Use, Unspecified With Other Opioid-induced Disorder
Intervention: Drug: Methylnaltrexone
13 Completed An Open-Label Evaluation of the Dose Proportionality of OROS� Hydromorphone HCL Tablets 8mg, 16mg, 32mg, 64mg
Condition: Analgesia
Intervention: Drug: OROS® Hydromorphone HCL; OROS® Dilaudid; Dilaudid SR (slow release); Naltrexone (an opioid antagonist).
14 Withdrawn HIV Risk Reduction and Drug Abuse Treatment in Iran
Conditions: Opiate Dependence;   HIV Infections
Interventions: Drug: Buprenorphine/Subutex;   Drug: Naltrexone;   Behavioral: Drug counseling
15 Completed Opioids and Esophageal Function
Conditions: Pharyngeal Dysfunction;   Esophageal Dysfunction
Intervention: Drug: methylnaltrexone
16 Completed Effectiveness of Alcohol Interventions Among Tuberculosis (TB) Patients in Tomsk Oblast, Russia
Conditions: Tuberculosis;   Alcohol Use Disorders
Interventions: Behavioral: Brief Counseling Intervention (BCI);   Drug: Naltrexone;   Other: BCI + Naltrexone;   Behavioral: Treatment as Usual
17 Recruiting Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
Condition: Cannabis Dependence
Intervention: Drug: Long-acting injectable naltrexone
18 Completed Medications Development for the Treatment of Cannabis Related Disorders
Conditions: Nicotine Withdrawal;   Marijuana Dependence;   Cannabis Dependence;   Nicotine Dependence;   Cannabis Abuse
Interventions: Drug: Placebo Aprepitant;   Drug: Active Aprepitant
19 Completed A Study to Assess How the Body Processes a Strong Painkiller When it is Given Alongside a Drug That Counteracts the Side Effects of Strong Painkillers in a Fasted and Fed State.
Condition: Pain
Interventions: Drug: 4 mg 12 hourly capsule - strong pain killer fasted;   Drug: 4 mg 12 hourly capsule - strong pain killer fed;   Drug: 12 hourly capsule strong painkiller with antagonist fasted);   Drug: 4 mg 12 hourly capsule strong painkiller with antagonist fed
20 Completed ALK33-001: A Study of RDC-0313 Administered to Healthy Adults
Condition: Alcohol Dependence
Interventions: Drug: RDC-0313;   Drug: Placebo

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Indicates status has not been verified in more than two years