326 studies found for:    "Alkylating Agents" | updated in the last 30 days
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Rank Status Study
1 Recruiting Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma
Condition: Newly Diagnosed Ewing Sarcoma
Interventions: Drug: Cyclophosphamide;   Device: Doxorubicin;   Drug: Vincristine;   Device: Ifosfamide;   Drug: Etoposide;   Procedure: Surgery;   Radiation: Radiation Therapy*;   Drug: Temozolomide;   Drug: Irinotecan
2 Recruiting Auto Transplant for High Risk or Relapsed Solid or CNS Tumors
Conditions: Ewing's Family Tumors;   Renal Tumors;   Hepatoblastoma;   Rhabdomyosarcoma;   Soft Tissue Sarcoma;   Primary Malignant Brain Neoplasms;   Retinoblastoma;   Medulloblastoma;   Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET);   Atypical Teratoid/Rhabdoid Tumor (AT/RT);   CNS Tumors;   Germ Cell Tumors
Interventions: Drug: Ifosfamide;   Drug: Etoposide;   Drug: Mesna;   Biological: G-CSF;   Drug: Busulfan;   Drug: Melphalan;   Drug: Thiotepa;   Biological: Autologous stem cell infusion;   Radiation: Radiation;   Drug: Carboplatin;   Drug: Paclitaxel;   Procedure: Leukapheresis
3 Recruiting Multimodal Molecular Targeted Therapy to Treat Relapsed or Refractory High-risk Neuroblastoma
Condition: Neuroblastoma Recurrent
Interventions: Drug: Dasatinib;   Drug: Rapamycin;   Drug: Irinotecan;   Drug: Temozolomide
4 Recruiting Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway
Conditions: Histologically Confirmed Medulloblastoma;   Activation of the Sonic Hedgehog (SHH) Pathway
Interventions: Drug: vismodegib;   Drug: Temozolomide
5 Not yet recruiting Efficacy and Safety of Bendamustine Plus Rituximab in Chronic Lympocytic Leukemia
Condition: Chronic Lymphocytic Leukemia
Intervention: Drug: Bendamustine + Rituximab
6 Not yet recruiting Prospective Pilot Trial to Assess a Multimodal Molecular Targeted Therapy in Children, Adolescent and Young Adults With Relapsed or Refractory High-grade Pineoblastoma
Condition: Pineoblastoma
Interventions: Drug: Temozolomide;   Drug: Irinotecan;   Drug: Dasatinib;   Drug: Rapamycin
7 Recruiting Cyclophosphamide for Hematopoietic Stem Cell Mobilization in Patients With a Hematologic Malignancy
Condition: Hematologic Malignancies
Intervention: Drug: Cyclophosphamide
8 Terminated Evaluating Cell Damage in Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, or Fanconi Anemia; in Patients Who Were Exposed to Alkylating Agents; and in Healthy Volunteers
Conditions: Leukemia;   Myelodysplastic Syndromes
Interventions: Genetic: cytogenetic analysis;   Genetic: fluorescence in situ hybridization;   Other: flow cytometry;   Procedure: biopsy
9 Not yet recruiting A Safety and Feasibility Study of AGS-003-LNG for the Treatment of Stage 3 Non Small Cell Lung Cancer
Condition: Non-small Cell Lung Cancer (NSCLC)
Interventions: Biological: AGS-003-LNG;   Drug: Carboplatin;   Drug: Abraxane;   Drug: Alimta;   Drug: Cisplatin;   Drug: Taxol;   Radiation: Radiation Therapy
10 Recruiting Trial Comparing Trabectedin to the Best Supportive Care in Patients With Sarcoma
Condition: Soft Tissue Sarcoma
Interventions: Drug: Trabectedin;   Drug: Dexamethasone
11 Recruiting Nimotuzumab in Combination With Radio-chemotherapy for the Treatment of Brainstem Tumor in Children
Condition: Childhood Brain Stem Neoplasm
Interventions: Drug: Nimotuzumab;   Drug: Temozolomide
12 Active, not recruiting IDA+BUCY vs BUCY Conditioning Regimen for Low-risk and Intermediate-risk AML Undergoing Auto-HSCT
Conditions: Autologous Hematopoietic Stem Cell Transplantation;   Acute Myeloid Leukemia;   Conditioning
Interventions: Drug: Idarubicin(IDA);   Drug: Busulfan (BU);   Drug: Cyclophosphamide (CY)
13 Not yet recruiting Study of Ibrutinib in Combination With Rituximab-CHOP in Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma
Condition: Epstein-Barr Virus-positive Diffuse Large B-cell Lymphoma
Interventions: Drug: Ibrutinib;   Drug: Rituximab;   Drug: Cyclophosphamide;   Drug: Doxorubicin;   Drug: vincristine;   Drug: Prednisolone
14 Recruiting ALL SCTped FORUM - Pharmacogenomic Study (add-on Study)
Condition: Acute Lymphoblastic Leukemia
Interventions: Genetic: Pharmacogenomics;   Other: Busulfan plasma level measurements
15 Active, not recruiting BuCY vs TBICY Conditioning Regimen for Standard-risk ALL Undergoing Allo-HSCT
Conditions: Allogeneic Hematopoietic Stem Cell Transplantation;   Busulfan;   Total Body Irradiation;   Acute Lymphocytic Leukemia
Interventions: Drug: Busulfan (BU);   Drug: Cyclophosphamide (CY);   Radiation: Total Body Irradiation (TBI)
16 Recruiting Autologous Hematopoietic Stem Cell Transplantation as Adjuvant Treatment for Triple Negative Breast Cancer Patients
Conditions: Triple-Negative Invasive Breast Carcinoma;   Recurrence
Interventions: Drug: Carmustine;   Drug: Cyclophosphamide;   Drug: Carboplatin;   Procedure: Autologous Hematopoietic Stem Cell Transplantation
17 Not yet recruiting Pharmacokinetic Study of Propylene Glycol-Free Melphalan HCl for Myeloablative Conditioning in Multiple Myeloma Patients Undergoing Autologous Transplantation
Condition: Multiple Myeloma
Intervention: Drug: Melphalan HCl for injection (propylene glycol free)
18 Not yet recruiting Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer).
Condition: Brain Neoplasms
Interventions: Drug: Nivolumab;   Drug: Temozolomide;   Radiation: Radiotherapy;   Other: Nivolumab Placebo
19 Recruiting Phase II Trial GA101 Inbrutinib B CLL
Condition: Leukemia, Lymphocytic, Chronic, B-Cell
Interventions: Drug: GA101;   Drug: Ibrutinib;   Drug: Cyclophosphamide;   Drug: Fludarabine
20 Not yet recruiting Study of Capecitabine and Cyclophosphamide Administered as a Single Pill in Patients With Advanced Breast Cancer
Condition: Breast Cancer Metastatic
Intervention: Drug: Fixed-dose combination of capecitabine and cyclophosphamide SAR439281

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Indicates status has not been verified in more than two years