412 studies found for:    "Alkylating Agents" | Studies updated in the last 30 days
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Rank Status Study
1 Not yet recruiting Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer
Conditions: Cancer;   Toxicity Due to Chemotherapy;   Sarcoma;   Osteosarcoma;   Lymphoma;   Ewing Sarcoma
Intervention: Drug: Triptorelin (GnRHa) + Chemotherapy
2 Recruiting Ovarian Reserve After Cancer: Longitudinal Effects
Conditions: Effects of Chemotherapy;   Premature Ovarian Failure
Intervention:
3 Recruiting Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma
Condition: Newly Diagnosed Ewing Sarcoma
Interventions: Drug: Cyclophosphamide;   Device: Doxorubicin;   Drug: Vincristine;   Device: Ifosfamide;   Drug: Etoposide;   Procedure: Surgery;   Radiation: Radiation Therapy*;   Drug: Temozolomide;   Drug: Irinotecan
4 Recruiting Denintuzumab Mafodotin (SGN-CD19A) Combined With RCHOP or RCHP Versus RCHOP Alone in Diffuse Large B-Cell Lymphoma or Follicular Lymphoma
Conditions: Diffuse, Large B-Cell, Lymphoma;   Follicular Lymphoma, Grade 3b;   Transformed Lymphoma / DLBCL
Interventions: Drug: denintuzumab mafodotin;   Drug: rituximab;   Drug: cyclophosphamide;   Drug: doxorubicin;   Drug: vincristine;   Drug: prednisone
5 Recruiting Auto Transplant for High Risk or Relapsed Solid or CNS Tumors
Conditions: Ewing's Family Tumors;   Renal Tumors;   Hepatoblastoma;   Rhabdomyosarcoma;   Soft Tissue Sarcoma;   Primary Malignant Brain Neoplasms;   Retinoblastoma;   Medulloblastoma;   Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET);   Atypical Teratoid/Rhabdoid Tumor (AT/RT);   CNS Tumors;   Germ Cell Tumors
Interventions: Drug: Ifosfamide;   Drug: Etoposide;   Drug: Mesna;   Biological: G-CSF;   Drug: Busulfan;   Drug: Melphalan;   Drug: Thiotepa;   Biological: Autologous stem cell infusion;   Radiation: Radiation;   Drug: Carboplatin;   Drug: Paclitaxel;   Procedure: Leukapheresis
6 Recruiting Cyclophosphamide for Hematopoietic Stem Cell Mobilization in Patients With a Hematologic Malignancy
Condition: Hematologic Malignancies
Intervention: Drug: Cyclophosphamide
7 Active, not recruiting A Phase II Study of Ibrutinib Plus FCR in Previously Untreated, Younger Patients With Chronic Lymphocytic Leukemia
Conditions: Chronic Lymphocytic Leukemia;   Leukemia
Interventions: Drug: Ibrutinib;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: Rituximab
8 Not yet recruiting Trial To Test Safety And Efficacy Of Vaccination For Incurable HPV 16-Related Oropharyngeal, Cervical And Anal Cancer
Conditions: Cancer of Head and Neck;   Cancer of Cervix;   Cancer of Anus
Interventions: Drug: DPX-E7 vaccine;   Drug: Cyclophosphamide
9 Active, not recruiting Combination Of Lapatinib With Carboplatin, Paclitaxel and Trastuzumab In Metastatic Breast Cancer
Condition: Neoplasms, Breast
Interventions: Drug: lapatinib;   Drug: carboplatin;   Drug: trastuzumab;   Drug: paclitaxel
10 Recruiting Assessing Fertility Potential in Female Cancer Survivors
Condition: Effects of Chemotherapy
Intervention:
11 Not yet recruiting Low Dose Total Skin Electron Beam Treatment (TSEBT) Followed by Maintenance Valchlor for Patients With Mycosis Fungoides
Conditions: Mycosis Fungoides;   Cutaneous T-cell Lymphoma
Intervention: Radiation: Total skin electron beam therapy
12 Recruiting Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment
Conditions: Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Interventions: Drug: Rituximab;   Drug: Nelarabine;   Drug: PEG-Asparaginase;   Procedure: Cranial irradiation;   Drug: Imatinib;   Drug: Idarubicin;   Drug: Dexamethasone;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: Vincristine;   Drug: Mercaptopurine;   Drug: VP16;   Drug: Daunorubicin (DNR);   Drug: Methotrexate;   Procedure: Stem cell transplantation;   Drug: Cytarabine;   Drug: Vindesine;   Drug: Adriamycin;   Drug: Prednisolone
13 Not yet recruiting Feasibility Study on LITT for Newly Diagnosed Glioblastoma
Condition: Glioblastoma
Intervention: Device: NeuroBlate System
14 Recruiting Haploidentical (Half-matched) Related Donor Stem Cell Transplantation Using Killer Immunoglobulin-like Receptors in Addition to Normal Selection Factors to Determine the Best Donor
Conditions: Leukemia;   Hematologic Malignancy
Interventions: Drug: melphalan;   Drug: fludarabine;   Drug: thiotepa;   Drug: Cyclophosphamide;   Drug: Mesna;   Drug: Mycophenolate Mofetil;   Drug: Filgrastim;   Drug: Tacrolimus
15 Recruiting A Randomised Phase II Open-label Study With a Phase Ib Safety lead-in Cohort of ONCOS-102, an Immune-priming GM-CSF Coding Oncolytic Adenovirus, and Pemetrexed/Cisplatin in Patients With Unresectable Malignant Pleural Mesothelioma
Condition: To Determine Safety, Tolerability and Efficacy of ONCOS-102 in Combination With Chemotherapy
Interventions: Biological: ONCOS-102;   Drug: Pemetrexed/cisplatin;   Drug: Cyclophosphamide
16 Recruiting Chidamide Combined With Cyclophosphamide、Prednisone、Thalidomide in Treatment of Fragile Patients With Relapse/Refratory Peripheral T Cell Lymphoma
Condition: Relapse/Refratory Peripheral T Cell Lymphoma
Intervention: Drug: C-CPT
17 Recruiting Trial of Adjuvant Chemotherapy in Breast Cancer Patients With Pathological Partial Response to Neoadjuvant Chemotherapy
Conditions: Invasive Ductal Breast Cancer;   Tubular Breast Cancer;   Mucinous Breast Cancer;   Inflammatory Breast Cancer
Interventions: Drug: Paclitaxel;   Drug: Cisplatin;   Drug: Epirubicin;   Drug: Cyclophosphamide;   Drug: 5-fluoruracil
18 Not yet recruiting Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute Lymphocytic Leukemia
Conditions: Leukemia;   Acute Lymphoblastic Leukemia
Interventions: Drug: Cyclophosphamide;   Drug: MESNA;   Drug: Dexamethasone;   Drug: Ofatumumab;   Drug: Methotrexate;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Cytarabine;   Drug: Rituximab;   Drug: Pegfilgrastim;   Drug: G-CSF;   Drug: Leucovorin;   Drug: Blinatumomab;   Drug: 6-Mercaptopurine;   Drug: Prednisone;   Behavioral: Phone Calls
19 Recruiting Anti-GPC3 CAR T for Recurrent or Refractory Lung Squamous Cell Carcinoma
Condition: Lung Squamous Cell Carcinoma
Interventions: Genetic: CAR-GPC3 T Cells;   Drug: Fludarabine;   Drug: Cyclophosphamide
20 Not yet recruiting Cyclophosphamide Versus Anti-thymocyte Globulin for GVHD Prophylaxis After RIC Allo-SCT
Condition: Graft vs Host Disease
Interventions: Drug: Cyclophosphamide;   Drug: Anti-Thymocyte Globulin;   Drug: Conditioning regimen

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Indicates status has not been verified in more than two years