| 1 |
NCT02007226 |
Recruiting |
Coronary Artery Calcification Score and Risk Factors for Coronary Artery Disease in Persons With Spinal Cord Injury |
|
|
Observational |
|
- James J. Peters Veterans Affairs Medical Center
|
U.S. Fed |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Coronary heart disease risk factors
- Postprandial lipemic response to a high fat meal(1.3 gm/kg body weight)
|
100 |
All |
45 Years to 75 Years (Adult, Senior) |
NCT02007226 |
BAU-11-075 |
CAC |
February 2012 |
December 2021 |
December 2022 |
December 10, 2013 |
September 1, 2017 |
|
- Kessler Institute for Rehabilitation
West Orange, New Jersey, United States - James J Peters VA Medical Center
The Bronx, New York, United States
|
| 2 |
NCT00001853 |
Recruiting |
Diabetes and Heart Disease Risk in Blacks |
- Cardiovascular
- Diabetes
- Obesity
- Hypertension
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Diabetes and Heart Disease Risk
|
1132 |
All |
18 Years to 65 Years (Adult) |
NCT00001853 |
990002
99-DK-0002 |
|
October 9, 1998 |
|
|
November 4, 1999 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 3 |
NCT02268513 |
Recruiting |
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Social Network Study |
|
|
Observational |
|
- Northwestern University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of MASALA participants with high kin density
|
900 |
All |
40 Years and older (Adult, Senior) |
NCT02268513 |
STU00083722
R01HL120725 |
|
September 2014 |
December 2017 |
February 2018 |
October 20, 2014 |
January 16, 2017 |
|
- University of California at San Francisco
San Francisco, California, United States - Northwestern University
Chicago, Illinois, United States
|
| 4 |
NCT03221114 |
Not yet recruiting |
Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular Disease |
- Uncontrolled Hypertension
- Cardiovascular Risk Factor
|
- Behavioral: Positive Psychological Intervention
|
Interventional |
Not Applicable |
- University of Illinois at Urbana-Champaign
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline Ambulatory Blood Pressure at 8- and 12-weeks
- Center for Epidemiological Studies Depression Scale (CESD): Change from Baseline Depressive Symptoms at 8- and 12-weeks
- Life Orientation Test-Revised (LOT-R): Change from Baseline Dispositional Optimism at 8- and 12-weeks
- (and 2 more...)
|
126 |
All |
18 Years and older (Adult, Senior) |
NCT03221114 |
1K01HL130712-01A1 |
|
September 2017 |
September 2020 |
July 2021 |
July 18, 2017 |
July 18, 2017 |
|
|
| 5 |
NCT02127671 |
Recruiting |
Intervention Trial to Decrease Cardiovascular Risk in Persons With Serious Mental Illness |
- Cardiovascular Risk Factors
- Serious Mental Illness
|
- Other: IDEAL intervention
- Other: Control
|
Interventional |
Not Applicable |
- Johns Hopkins University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- global Framingham Risk Score
- weight
- BMI
- (and 12 more...)
|
250 |
All |
18 Years and older (Adult, Senior) |
NCT02127671 |
NA_00072197
R01HL112299 |
IDEAL |
December 2013 |
November 2018 |
November 2018 |
May 1, 2014 |
February 6, 2018 |
|
- Johns Hopkins ProHealth Clinical Research Facility
Woodlawn, Maryland, United States
|
| 6 |
NCT02950818 |
Recruiting |
A Partnership to Translate an Evidence-based Intervention (Take Heart) for Vulnerable Older Adults With Heart Disease |
|
|
Interventional |
Not Applicable |
- University of Michigan
- National Institute on Aging (NIA)
- Detroit Medical Center
- Detroit Area Agency on Aging
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Hospitalizations
- Emergency Department Visits
- Health-related quality of life
- Cardiac symptom experience
|
376 |
All |
50 Years and older (Adult, Senior) |
NCT02950818 |
HUM00092196
1R01AG047203-01A1 |
|
December 2016 |
December 2020 |
March 2021 |
November 1, 2016 |
March 19, 2018 |
|
- University of Michigan, School of Public Health
Ann Arbor, Michigan, United States
|
| 7 |
NCT03012022 |
Recruiting |
Cleveland Heart and Metabolic Prevention Study |
- Heart Failure Risk Factors in Healthy Individuals
|
|
Observational |
|
- The Cleveland Clinic
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Correlation between metabolic and/or nitrative stress markers and predefined clinical endpoints
- Determination of sub-clinical myocardial dysfunction by echocardiogram
- Correlation between functional capacity, as measured by DASI questionnaire, and markers of metabolic and nitrative stress
- (and 3 more...)
|
2000 |
All |
18 Years and older (Adult, Senior) |
NCT03012022 |
10-727
1R01HL103931 |
CHAMPS |
November 2010 |
December 2019 |
December 2019 |
January 6, 2017 |
January 26, 2018 |
|
- Cleveland Clinic
Cleveland, Ohio, United States
|
| 8 |
NCT02055209 |
Recruiting |
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST) |
- Hypertension
- Cardiovascular Disease
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
- To develop a novel genomic science resource for defining the functional significance and human biology consequences of ancestry-related genomic variation in AA.
|
2019 |
All |
21 Years to 65 Years (Adult) |
NCT02055209 |
140048
14-HG-0048 |
|
February 4, 2014 |
June 4, 2018 |
June 4, 2018 |
February 5, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 9 |
NCT03437798 |
Recruiting |
Genomic Determinants and Shared Genetic Pathways of Periodontal Disease |
- Periodontal Diseases
- Diabetes
- Osteoporosis
- Cardiovascular Risk Factor
|
|
Observational |
|
- Tufts University
- Brigham and Women's Hospital
- National Institute of Dental and Craniofacial Research (NIDCR)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Other
|
- Validity of self-reported periodontal disease
- Correlation of CDC-AAP periodontal condition questions vs. periodontal disease diagnosis
|
360 |
Female |
45 Years to 100 Years (Adult, Senior) |
NCT03437798 |
HH1804
1K23DE026804-01 |
|
January 30, 2018 |
May 31, 2022 |
August 31, 2022 |
February 19, 2018 |
February 19, 2018 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States
|
| 10 |
NCT02697422 |
Recruiting |
Veteran Peer Coaches Optimizing and Advancing Cardiac Health |
- Cardiovascular Disease (CVD)
- Hypertension
- Hyperlipemia
- Obesity
|
- Other: Community-based peer health coach intervention
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Reduction in systolic blood pressure
- Reduction in Framingham Cardiovascular risk score
- Tobacco use
- (and 5 more...)
|
400 |
All |
up to 75 Years (Child, Adult, Senior) |
NCT02697422 |
IIR 14-063 |
Vet-COACH |
May 30, 2017 |
August 31, 2020 |
February 28, 2021 |
March 3, 2016 |
April 18, 2018 |
|
- VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, United States
|
| 11 |
NCT01809288 |
Recruiting |
Identifying Risk for Diabetes and Heart Disease in Women |
- Obesity
- Insulin Resistance
- Triglycerides
- Diabetes
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Determine if there are differences in African, African-American and white women in the relationship between triglyceride levels, (a frequently used screening test for diabetes and heart disease) glucose tolerance status and insulin resistance.
|
360 |
Female |
25 Years to 65 Years (Adult) |
NCT01809288 |
130090
13-DK-0090 |
|
March 9, 2013 |
April 30, 2022 |
April 30, 2022 |
March 12, 2013 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 12 |
NCT02124109 |
Recruiting |
The Genetic Basis of Acquired Heart Disease in Africa |
- Rheumatic Heart Disease
- Rheumatic Fever
- Endomyocardial Fibrosis
- Acquired Heart Disease
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Conduct genome wide association studies of case-control series for Rheumatic Heart Disease and Endomyocardial fibrosis cases in sub-Saharan Africa
|
2000 |
All |
up to 100 Years (Child, Adult, Senior) |
NCT02124109 |
999914098
14-HG-N098 |
|
April 25, 2014 |
December 1, 2020 |
December 1, 2020 |
April 28, 2014 |
January 23, 2018 |
|
- University of Lagos
Lagos, Nigeria - Mulago Hospital
Kampala, Uganda
|
| 13 |
NCT02021669 |
Recruiting |
Omega-3 for Depression and Other Cardiac Risk Factors - 2 |
|
- Drug: Omega-3 supplement
- Drug: Placebo
|
Interventional |
Phase 2 |
- Washington University School of Medicine
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Beck Depression Inventory - 2 (BDI-2)
- Hamilton Depression Rating Scale (HAMD-17)
- Heart Rate Variability (HRV)
- Interleukin-6 (IL-6)
|
150 |
All |
30 Years to 75 Years (Adult, Senior) |
NCT02021669 |
201309002
R01HL117805 |
Omega-3(2) |
April 2014 |
June 30, 2018 |
December 2018 |
December 27, 2013 |
March 2, 2018 |
|
- Washington University Medical Center
Saint Louis, Missouri, United States
|
| 14 |
NCT03068390 |
Recruiting |
Rural Intervention for Caregivers' Heart Health |
- Cardiovascular Risk Factor
|
- Behavioral: RICHH Intervention
- Behavioral: Usual care
|
Interventional |
Not Applicable |
- Debra Moser
- National Institute of Nursing Research (NINR)
- University of Kentucky
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Change in Lipid Profile Derived from point-of-care testing
- Change in Body Mass Index (kg/m2) calculated from height and weight
- Change in Blood Pressure in mmHg
- (and 4 more...)
|
280 |
All |
21 Years and older (Adult, Senior) |
NCT03068390 |
1R01NR016824 |
RICHH |
February 24, 2017 |
August 21, 2021 |
August 21, 2021 |
March 1, 2017 |
March 1, 2017 |
|
- University of Kentucky
Lexington, Kentucky, United States
|
| 15 |
NCT03196024 |
Recruiting |
Corazon de la Familia (Heart of the Family) |
- Risk Reduction Behavior
- Diabetes Mellitus, Type 2
- Cardiovascular Diseases
|
- Behavioral: Family-focused intervention arm
- Behavioral: Individual-focused intervention arm
|
Interventional |
Not Applicable |
- University of Kentucky
- National Institute of Nursing Research (NINR)
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in body mass index (BMI)
- Change in blood pressure
- Change in lipid profile
- (and 5 more...)
|
440 |
All |
18 Years and older (Adult, Senior) |
NCT03196024 |
1R01NR016262-01A1 |
|
October 5, 2017 |
July 31, 2021 |
July 31, 2021 |
June 22, 2017 |
November 7, 2017 |
|
- University of Kentucky
Lexington, Kentucky, United States
|
| 16 |
NCT02115724 |
Recruiting |
Nitric Oxide Bioavailability and Early Life Stress (NO-Stress) |
|
- Dietary Supplement: Antioxidant cocktail
- Other: Biopsy
- Other: Placebo
- Drug: NMD; 0.4mg sub-lingual nitroglycerin spray
|
Interventional |
Not Applicable |
- Augusta University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Acute Change in Flow mediated dilation
- Acute Change in Biomarkers of oxidative stress
- Acute Change in Arterial Stiffness
- Acute change in Flow mediated dilation
|
340 |
All |
18 Years to 40 Years (Adult) |
NCT02115724 |
NO-Stress Pro00001887
5P01HL069999 |
NO-Stress |
April 2014 |
April 2019 |
April 2020 |
April 16, 2014 |
November 9, 2017 |
|
- Georgia Prevention Institute , Georgia Regents University
Augusta, Georgia, United States
|
| 17 |
NCT02252081 |
Recruiting |
Metformin in Kidney Disease |
- Chronic Kidney Disease
- Cardiovascular Disease
- Metabolic Syndrome
|
- Drug: metformin
- Drug: Placebo
|
Interventional |
Phase 2 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- leptin to adiponectin ratio (LAR)
- estimated glomerular filtration rate (eGFR)
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT02252081 |
ENDA-014-13F
1I01CX000982-01A1 |
|
October 1, 2014 |
December 31, 2019 |
December 31, 2019 |
September 29, 2014 |
January 19, 2018 |
|
- Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, Tennessee, United States
|
| 18 |
NCT01143454 |
Recruiting |
Characterization of Patients With Uncommon Presentations and/or Uncommon Diseases Associated With the Cardiovascular System |
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
100099 |
All |
2 Years to 100 Years (Child, Adult, Senior) |
NCT01143454 |
100126
10-H-0126 |
|
May 14, 2010 |
|
|
June 14, 2010 |
April 4, 2018 |
|
- Suburban Hospital
Bethesda, Maryland, United States - National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 19 |
NCT02230891 |
Recruiting |
Biomarker Guided Therapies in Stage A/B Heart Failure |
- Hypertension
- Diabetes
- Cardiovascular Disease
|
- Drug: Carvedilol
- Drug: Spironolactone
|
Interventional |
Phase 2 |
- VA Office of Research and Development
- Baylor College of Medicine
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Cardiac Strain
- Change in biomarkers
- arterial stiffness
|
210 |
All |
40 Years to 85 Years (Adult, Senior) |
NCT02230891 |
CLNB-009-13F |
|
October 1, 2014 |
December 31, 2018 |
December 31, 2018 |
September 3, 2014 |
January 4, 2018 |
|
- Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States
|
| 20 |
NCT03423238 |
Recruiting |
Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE) |
- Obesity
- Weight Loss
- CHD - Coronary Heart Disease
|
- Other: Exercise
- Other: Meeting with Dietitian
- Behavioral: Health Education
- (and 4 more...)
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Study Feasibilty
- Compliance
- Change in Body weight
- (and 9 more...)
|
40 |
All |
50 Years to 80 Years (Adult, Senior) |
NCT03423238 |
IRB00046110
1R56HL134989-01A1 |
TOPCARE |
March 21, 2018 |
August 31, 2019 |
August 31, 2019 |
February 6, 2018 |
March 22, 2018 |
|
- Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
|
| 21 |
NCT02991534 |
Recruiting |
Cardiovascular Risk Screening and Risk Reduction in Women Vets |
- Cardiovascular Diseases
- Hypertension
- Hyperlipidemias
- (and 5 more...)
|
- Behavioral: CV Toolkit Components
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Referrals to Health Promotion and Disease Prevention Services
- Altarum Consumer Engagement (ACE)
- PROMIS Global Health
- (and 3 more...)
|
260 |
Female |
18 Years and older (Adult, Senior) |
NCT02991534 |
QUX 16-007 |
|
November 15, 2016 |
November 30, 2018 |
September 30, 2020 |
December 13, 2016 |
December 15, 2017 |
|
- VA Greater Los Angeles Healthcare System, Sepulveda, CA
Sepulveda, California, United States - VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States - VA Connecticut Healthcare System West Haven Campus, West Haven, CT
West Haven, Connecticut, United States
|
| 22 |
NCT02853149 |
Recruiting |
A Lifestyle Intervention Targeting Enhanced Health and Function for Persons With Chronic SCI in Caregiver/Care-Receiver Relationships: Effects of Caregiver Co-Treatment |
- Spinal Cord Injury
- Cardiovascular Diseases
- Obesity
|
- Behavioral: Spinal Cord Injury (SCI)
- Behavioral: Caregiver Intervention(CCC)
- Behavioral: Caregiver Control (CC)
|
Interventional |
Not Applicable |
- University of Miami
- National Institute on Disability, Independent Living, and Rehabilitation Research
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in Fitness indicators as measured by Body Mass index (BMI)
- Change from baseline in Cardioendocrine and Global Cardiovascular risk by surrogate blood measures of the Homeostasis Model Assessment -Insulin Resistance (HOMA 2-IR) in SCI individuals and caregivers
- Change from baseline in Cardioendocrine and Global Cardiovascular risk by surrogate blood measures of the Total Cholesterol(TC): High Density high-density lipoprotein(HDL) ratio in SCI individuals and caregivers
- (and 4 more...)
|
120 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02853149 |
20151065 |
DRPP |
June 26, 2016 |
September 30, 2020 |
September 30, 2021 |
August 2, 2016 |
January 12, 2018 |
|
- Craig Hospital
Englewood, Colorado, United States - University of Miami- The Miami Project to Cure Paralysis
Miami, Florida, United States
|
| 23 |
NCT02641496 |
Recruiting |
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD |
- Obstructive Sleep Apnea
- PTSD
- Posttraumatic Stress Disorder
|
- Behavioral: CBT-OSA
- Behavioral: Sleep Education
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Time in hours of "mask-on" CPAP usage per night
- Functional Outcomes of Sleep Questionnaire (FOSQ)
- California Verbal Learning Test, Second Edition (CVLT-II)
- PTSD Checklist for DSM-5 (PCL-5)
|
144 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02641496 |
D1799-R |
|
January 1, 2017 |
December 31, 2020 |
December 31, 2021 |
December 29, 2015 |
March 2, 2018 |
|
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
|
| 24 |
NCT02626442 |
Recruiting |
Exercise and Brain Health |
- Stroke
- Cardiovascular Risk Factors
- Transient Ischemic Attack (TIA)
|
|
Interventional |
Not Applicable |
- Baltimore VA Medical Center
- University of Maryland
|
U.S. Fed / Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from Baseline in executive function
- Change from baseline in cortical thickness
- Change from baseline in EEG
- Change from baseline in hippocampal volume
|
300 |
All |
18 Years to 95 Years (Adult, Senior) |
NCT02626442 |
BaltimoreVAMC |
EBH |
July 2013 |
January 2020 |
January 2025 |
December 10, 2015 |
November 1, 2016 |
|
- Baltimore VA Medical Center
Baltimore, Maryland, United States
|
| 25 |
NCT02188381 |
Recruiting |
The Role of Gut Microbiota in Hypertension |
|
- Other: Stool Sample and Blood Sample
|
Observational |
|
- University of Florida
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Characterize gut microbiota composition at phylum level
- Characterize gut microbiota composition at genus level
- Reduction in BP is associated with changes in gut microbiota composition in RH subjects.
|
398 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02188381 |
IRB201400233-N
1R01HL132448-01 |
|
July 2014 |
December 2018 |
December 2018 |
July 11, 2014 |
April 5, 2018 |
|
- Cardiovascular Clinic at UF Health
Gainesville, Florida, United States
|
| 26 |
NCT01778569 |
Recruiting |
The Psoriasis, Atherosclerosis, and Cardiometabolic Disease Initiative (PACI) |
- Metabolic Disease
- Cardiovascular Disease
- Inflammation
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Our primary outcome of interest is vascular inflammation measured by standard uptake values from PET-CT imaging with FDG.
|
1200 |
All |
18 Years and older (Adult, Senior) |
NCT01778569 |
130065
13-H-0065 |
|
January 26, 2013 |
June 30, 2022 |
December 31, 2030 |
January 29, 2013 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 27 |
NCT03220204 |
Recruiting |
Researching Emotions And Cardiac Health: Phase III |
- Congestive Heart Failure
- Emotions
- Patient Compliance
|
- Behavioral: PP-based health behavior intervention
- Behavioral: MI-based educational control condition
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Feasibility of the PP-based health behavior intervention
- Changes in PANAS Scores (primary psychological outcome)
- Changes in LOT-R Scores
- (and 11 more...)
|
75 |
All |
18 Years and older (Adult, Senior) |
NCT03220204 |
5K23HL123607-03 |
REACH III |
September 1, 2017 |
November 1, 2019 |
November 1, 2019 |
July 18, 2017 |
October 4, 2017 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
| 28 |
NCT02791685 |
Recruiting |
Smartphone Delivered In-home Cardiopulmonary Rehabilitation |
- Cardiovascular Disease
- Coronary Artery Disease
|
- Behavioral: MULTIFIT Cardiac Rehabilitation
- Behavioral: Movn Pulmonary Rehabilitation
- Behavioral: Standard of Care Cardiac Rehabilitation
|
Interventional |
Not Applicable |
- Emory University
- Atlanta VA Medical Center
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Functional Capacity assessed by the Six Minute Walk Test (6MWT)
- Change in Measure of Exercise Intensity (MET)
- Change in Weight
- (and 19 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02791685 |
IRB00085938 |
|
May 2016 |
December 2019 |
December 2020 |
June 7, 2016 |
January 11, 2018 |
|
- Atlanta VA Medical Center
Atlanta, Georgia, United States
|
| 29 |
NCT03288207 |
Not yet recruiting |
Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments |
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Steps per day as measured by the PA (physical activity) device
|
180 |
Female |
18 Years to 75 Years (Adult, Senior) |
NCT03288207 |
170162
17-H-0162 |
|
April 25, 2018 |
December 31, 2020 |
December 31, 2020 |
September 20, 2017 |
April 20, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
| 30 |
NCT02956590 |
Not yet recruiting |
Dyslipidemia of Obesity Intervention in Teens |
|
- Drug: Pitavastatin
- Drug: Placebo
|
Interventional |
Phase 3 |
- New England Research Institutes
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- the effect of pitavastatin versus placebo on vascular measures in at least 354 obese adolescents with combined dyslipidemia of obesity (CDO)
- the effect of pitavastatin versus placebo on vascular measures in obese adolescents with combined dyslipidemia of obesity (CDO)
- the effect of pitavastatin versus placebo on vascular measures in at least 354 obese adolescents with combined dyslipidemia of obesity
- (and 10 more...)
|
354 |
All |
10 Years to 17 Years (Child) |
NCT02956590 |
PHN DO-IT |
DO-IT |
January 2017 |
June 2020 |
July 2020 |
November 7, 2016 |
March 23, 2018 |
|
|
| 31 |
NCT02133885 |
Recruiting |
Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients |
|
- Drug: Minocycline Group
- Other: Placebo Group
|
Interventional |
Phase 1
Phase 2 |
- University of Florida
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Reduction of ambulatory blood pressure
|
101 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02133885 |
IRB201500594-N
RO1HL3361028
2013-00102 Study 2
R01HL132448-01 |
|
December 2016 |
May 2018 |
May 2018 |
May 8, 2014 |
April 5, 2018 |
|
- UF Health Cardiovascular Clinic
Gainesville, Florida, United States
|
| 32 |
NCT02970123 |
Recruiting |
Sit Less, Interact, Move More (SLIMM) Intervention for Sedentary Behavior in Chronic Kidney Disease (CKD) |
|
- Behavioral: Sit Less, Interact, Move More (SLIMM)
|
Interventional |
Not Applicable |
- Srinvasan Beddhu
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Utah
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in Sedentary Activity Duration
- Change in Casual Walking Duration
- Change in Waist Circumference
- (and 2 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02970123 |
IRB_00093477
1R21DK106574-01A1 |
SLIMM |
December 2016 |
September 2018 |
September 2018 |
November 21, 2016 |
January 23, 2017 |
|
- University of Utah
Salt Lake City, Utah, United States
|
| 33 |
NCT02133872 |
Recruiting |
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients |
|
- Drug: Minocycline 100mg Group
- Drug: Minocycline 200mg Group
|
Interventional |
Phase 1 |
- University of Florida
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction in High Blood Pressure
- Renal function changes
|
175 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02133872 |
2013-00102 Study 1-N
RO1HL3361028 |
|
October 2014 |
August 2018 |
August 2018 |
May 8, 2014 |
April 5, 2018 |
|
- UF Health Cardiovascular Clinic
Gainesville, Florida, United States
|
| 34 |
NCT02548767 |
Recruiting |
Adverse Metabolic Effects of Dietary Sugar |
- Chronic Disease of Cardiovascular System
- Type 2 Diabetes
- Obesity
|
- Other: high fructose corn syrup
- Other: aspartame
- Other: Energy-balanced diet
- Other: Ad libitum diet
|
Interventional |
Not Applicable |
- University of California, Davis
- Touro University, California
- University of Southern California
- (and 2 more...)
|
Other / U.S. Fed / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Basic Science
|
- Change of de novo lipogenesis: palmitate tracer-to-tracee ratios by gas chromatography-mass spectrometry.
- Change of endogenous glucose production measured by standard dilution techniques
- Change of whole body insulin sensitivity
- (and 3 more...)
|
72 |
All |
18 Years to 40 Years (Adult) |
NCT02548767 |
499106
1R01HL121324 |
|
February 2016 |
June 2019 |
June 2020 |
September 14, 2015 |
July 14, 2017 |
|
- University of California, Davis
Davis, California, United States - Clinical Research Center
Sacramento, California, United States - Touro University California Translational Research Clinic and Student Health Clinic
Vallejo, California, United States
|
| 35 |
NCT02455336 |
Recruiting |
Fenofibrate Treatment in SCI |
- Spinal Cord Injury
- Dyslipidemia
|
- Drug: Fenofibrate
- Other: No intervention
|
Interventional |
Phase 2
Phase 3 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Triglyceride concentration (mg/dl)
|
30 |
All |
21 Years to 69 Years (Adult, Senior) |
NCT02455336 |
B1925-P |
|
May 18, 2015 |
June 1, 2018 |
June 1, 2018 |
May 27, 2015 |
January 30, 2018 |
|
- Kessler Institute for Rehabilitation
West Orange, New Jersey, United States - James J. Peters VA Medical Center, Bronx, NY
Bronx, New York, United States
|
| 36 |
NCT02501746 |
Recruiting |
Bridging Income Generation With Group Integrated Care |
- Cardiovascular Disease
- Diabetes
|
- Other: Usual Clinical Care
- Other: Group Medical Visits
- Other: Microfinance Groups
|
Interventional |
Not Applicable |
- Icahn School of Medicine at Mount Sinai
- Moi University College of Health Sciences
- Brown University
- (and 3 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change in Systolic Blood Pressure
- Change in cardiovascular disease (CVD) risk Score
|
3600 |
All |
35 Years and older (Adult, Senior) |
NCT02501746 |
GCO 14-0233
1R01HL125487 |
BIGPIC |
February 6, 2017 |
September 2019 |
September 2020 |
July 17, 2015 |
April 11, 2018 |
|
- Moi University College of Health Sciences
Eldoret, Kenya
|
| 37 |
NCT03129048 |
Recruiting |
Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults |
- Cognition
- Obese Older Adults
- Mediterranean Diet
|
|
Interventional |
Not Applicable |
- University of Illinois at Chicago
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- Attention
- Executive Function
- Memory
|
180 |
All |
55 Years to 85 Years (Adult, Senior) |
NCT03129048 |
2016-0258 |
|
September 1, 2016 |
April 1, 2020 |
March 1, 2021 |
April 26, 2017 |
April 26, 2017 |
|
- University Of Illinois at Chicago
Chicago, Illinois, United States
|
| 38 |
NCT02339025 |
Not yet recruiting |
DoD-NCI TRICARE Feasibility Study |
|
|
Observational |
|
- National Cancer Institute (NCI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- Participation rates
- Data linkage
- Cross-sectional biomarker study
|
1000 |
All |
35 Years to 74 Years (Adult, Senior) |
NCT02339025 |
999915062
15-C-N062 |
|
January 14, 2015 |
September 22, 2020 |
September 20, 2021 |
January 15, 2015 |
February 14, 2018 |
|
- Walter Reed National Medical Center
Bethesda, Maryland, United States
|
| 39 |
NCT03465917 |
Recruiting |
Physiological Study of the Efficacy and Mechanistic Effects of Alcohol Renal Denervation |
|
- Combination Product: Renal Denervation
|
Interventional |
Early Phase 1 |
- University of Texas Southwestern Medical Center
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Renal sympathetic activity
- Blood pressure
- Muscle sympathetic activity
- (and 2 more...)
|
5 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03465917 |
STU 112014-023 |
|
March 1, 2018 |
February 2019 |
February 2019 |
March 14, 2018 |
March 14, 2018 |
|
- The Institute for Exercise and Environmental Medicine
Dallas, Texas, United States
|
| 40 |
NCT01877551 |
Recruiting |
Tauroursodeoxycholic Acid for Protease-inhibitor Associated Insulin Resistance |
- HIV Related Insulin Resistance
- Protease Inhibitor Related Insulin Resistance
- Endoplasmic Reticulum Stress
|
- Drug: Tauroursodeoxycholic acid
- Other: Placebo tablet
|
Interventional |
Not Applicable |
- Washington University School of Medicine
- National Institutes of Health (NIH)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Insulin sensitivity
- Endoplasmic reticulum stress
- Thyroid hormone deiodinase expression in muscle
- (and 3 more...)
|
48 |
All |
18 Years to 65 Years (Adult) |
NCT01877551 |
201306105
R01DK096982 |
|
September 2013 |
July 2018 |
July 2018 |
June 13, 2013 |
May 23, 2016 |
|
- Washington University School of Medicine
St. Louis, Missouri, United States
|
| 41 |
NCT03170375 |
Not yet recruiting |
Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome |
|
- Behavioral: Performance of WHEELS-I in promoting DASH/SRD adoption
- Behavioral: Effects of a 2-week DASH/SRD intervention vs. control diet on HFpEF functional cardiovascular risk factors
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Carotid-femoral pulse wave velocity
- Left ventricular mass index
- Ventricular stiffness
- (and 3 more...)
|
130 |
All |
45 Years and older (Adult, Senior) |
NCT03170375 |
CARA-009-16F
9050 |
|
June 4, 2018 |
December 30, 2022 |
December 30, 2022 |
May 31, 2017 |
February 26, 2018 |
|
- VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, Michigan, United States
|
| 42 |
NCT02162550 |
Recruiting |
Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus |
|
- Drug: Bydureon
- Drug: placebo
|
Interventional |
Phase 4 |
- Phoenix VA Health Care System
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in carotid plaque volume
- Change in reactive hyperemic index
- Change in carotid plaque composition
|
148 |
All |
21 Years to 75 Years (Adult, Senior) |
NCT02162550 |
1026 |
|
June 2014 |
June 2018 |
June 2018 |
June 12, 2014 |
February 10, 2017 |
|
- Phoenix VA Health Care System
Phoenix, Arizona, United States
|
| 43 |
NCT03120416 |
Recruiting |
Resistance Exercise Training in Chronic Kidney Disease |
|
- Behavioral: Resistance exercise training
|
Interventional |
Not Applicable |
- University of Illinois at Chicago
- National Institutes of Health (NIH)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Endothelial function
- Vascular function
- Carotid artery stiffness
- (and 6 more...)
|
32 |
All |
21 Years and older (Adult, Senior) |
NCT03120416 |
2016-0421
K23DK094829 |
|
January 25, 2017 |
July 31, 2018 |
July 31, 2018 |
April 19, 2017 |
April 19, 2017 |
|
- University of Illinois at Chicago
Chicago, Illinois, United States
|
| 44 |
NCT03256890 |
Recruiting |
Mindfulness-Based Blood Pressure Reduction: Stage 2a RCT |
- Hypertension
- Prehypertension
|
- Behavioral: MB-BP Intervention
- Other: Enhanced Usual Care Control
|
Interventional |
Not Applicable |
- Brown University
- National Institutes of Health (NIH)
- National Center for Complementary and Integrative Health (NCCIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Systolic blood pressure
- Sustained Attention to Response Task (SART)
- Mindful Attention Awareness Scale (MAAS)
- (and 12 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03256890 |
1412001171
1UH2AT009145 |
MB-BP |
June 13, 2017 |
June 30, 2020 |
June 30, 2020 |
August 22, 2017 |
October 31, 2017 |
|
- Brown University School of Public Health
Providence, Rhode Island, United States
|
| 45 |
NCT02568930 |
Recruiting |
SUSTAIN-IT: Sustaining Quality of Life of the Aged: Heart Transplant or Mechanical Support? |
|
|
Observational |
|
- Northwestern University
- National Institute on Aging (NIA)
|
Other / NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Non-inferior change in patient HRQOL
- Non-inferior change in caregiver HRQOL
- Risk factors related to poorer patient overall HRQOL
- (and 3 more...)
|
800 |
All |
60 Years to 80 Years (Adult, Senior) |
NCT02568930 |
STU00200851
1R01AG047416 |
SUSTAIN-IT |
July 2015 |
December 2019 |
March 2020 |
October 6, 2015 |
November 29, 2017 |
|
- University of Alabama at Birmingham (UAB)
Birmingham, Alabama, United States - Florida Hospital
Orlando, Florida, United States - Northwestern University
Chicago, Illinois, United States - (and 10 more...)
|
| 46 |
NCT03255746 |
Not yet recruiting |
HELP-HY: Health Education and sLeep Program in HYpertension |
- Prehypertension
- Hypertension
|
- Behavioral: Sleep Enhancement
- Behavioral: Health Education
|
Interventional |
Not Applicable |
- Mayo Clinic
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- change in 24-hour mean arterial pressure
- changes in 24-hour heart rate
- changes in baroreflex sensitivity
- (and 8 more...)
|
94 |
All |
18 Years to 65 Years (Adult) |
NCT03255746 |
17-004044
R01HL134808 |
|
April 1, 2018 |
June 30, 2022 |
June 30, 2022 |
August 21, 2017 |
March 5, 2018 |
|
- Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
| 47 |
NCT03417388 |
Recruiting |
Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD |
|
- Drug: High dose potent statin
- Drug: Evolocumab
- Drug: ACE-I (lisinopril) or ARB (losartan)
- (and 3 more...)
|
Interventional |
Phase 4 |
- University of Florida
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- All Cause Death incidents reported between the two groups
- Non-fatal myocardial infarction (MI) incidents reported between the two groups
- Stroke/TIA incidents reported between the two groups
- (and 2 more...)
|
4422 |
Female |
18 Years to 100 Years (Adult, Senior) |
NCT03417388 |
IRB201701142 -A
PR161603 |
WARRIOR |
February 9, 2018 |
December 30, 2021 |
December 30, 2022 |
January 31, 2018 |
February 14, 2018 |
|
- Family Medicine at Eastside Community Practice
Gainesville, Florida, United States - Family Medicine at Hampton Oaks Medical Plaza (Adults and Peds)
Gainesville, Florida, United States - Internal Medicine at Tower Hill
Gainesville, Florida, United States - (and 8 more...)
|
| 48 |
NCT03491202 |
Recruiting
New |
The Genetic Basis for Atrial Fibrillation |
|
|
Observational |
|
- Jesse Brown VA Medical Center
|
U.S. Fed |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Symptoms related to atrial fibrillation (chest pain, dyspnea, palpitations)
- heart rate
|
600 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT03491202 |
977544 |
|
May 25, 2017 |
May 2022 |
May 2022 |
April 9, 2018 |
April 9, 2018 |
|
- Jesse Brown VA Medical Center
Chicago, Illinois, United States
|
| 49 |
NCT01836354 |
Recruiting |
Discharge Educational Strategies for Reduction of Vascular Events |
- Intracerebral Infarcts
- Ischemic Stroke
- Hemorrhagic Strokes
- TIA's
|
- Behavioral: DESERVE education
|
Interventional |
Not Applicable |
- New York University School of Medicine
- Columbia University
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Blood Pressure
- Secondary Incident
|
800 |
All |
18 Years and older (Adult, Senior) |
NCT01836354 |
14-00718 |
DESERVE |
August 2012 |
December 2018 |
December 2018 |
April 19, 2013 |
March 6, 2018 |
|
- NYU Langone Medical Center
New York, New York, United States - Icahn School of Medicine at Mount Sinai
New York, New York, United States - Columbia University
New York, New York, United States
|
| 50 |
NCT02373241 |
Recruiting |
Preventing Sickle Cell Kidney Disease |
- Anemia, Sickle Cell
- Sickle Cell Disease
- Kidney Disease
- (and 2 more...)
|
|
Interventional |
Phase 2 |
- University of Alabama at Birmingham
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Feasibility as measured by the number of patients that accept enrollment, remain adherent to losartan, and remain adherent to study procedures.
- Feasibility as measured by number of patients with adverse events to losartan.
- To prospectively evaluate the incidence of hypertension (clinic and ambulatory) in patients with SCD and number of patients with abnormal blood pressure biomarkers.
- Feasibility as measured by the number of patients with improvement in nocturnal blood pressure while receiving losartan.
|
40 |
All |
5 Years to 25 Years (Child, Adult) |
NCT02373241 |
F141107009
1K23HL127100-01 |
|
April 2015 |
April 2020 |
April 2020 |
February 26, 2015 |
May 1, 2017 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States
|
Create an RSS feed from your search for:
Download the search results for: