1 |
NCT03051139 |
Not yet recruiting |
A Strategy to Improve Implementation of LTVV for Patients w/ ARDS |
- Acute Respiratory Distress Syndrome
|
- Behavioral: Multi-component LTVV implementation strategy
|
Interventional |
Not Applicable |
- Northwestern University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- LTVV rate
- Difference in proportions of patients receiving LTVV between intervention and usual care groups during pre-trial period
- Difference in proportions of patients receiving LTVV between intervention and usual care groups during trial period
- (and 16 more...)
|
264 |
All |
18 Years and older (Adult, Senior) |
NCT03051139 |
STU00202855 K23HL118139 |
|
March 2017 |
December 2017 |
October 2019 |
February 13, 2017 |
February 23, 2017 |
|
- Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States
|
2 |
NCT00006496 |
Recruiting |
Molecular Epidemiology of ARDS |
- Acute Respiratory Distress Syndrome
- Lung Diseases
|
|
Observational |
|
- Massachusetts General Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
4000 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00006496 |
937 R01HL060710 |
|
February 2000 |
August 2019 |
December 2019 |
November 17, 2000 |
March 27, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
3 |
NCT03096314 |
Recruiting |
Vitamin D to Improve Outcomes by Leveraging Early Treatment |
- Acute Respiratory Distress Syndrome
- Vitamin D Deficiency
- Critical Illness
|
- Drug: Vitamin D3
- Drug: Placebo
|
Interventional |
Phase 3 |
- Massachusetts General Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- All-cause, all-location mortality to day 90
- Hospital length of stay among survivors to day 90
- Healthcare facility length of stay among survivors to day 90
- (and 13 more...)
|
3000 |
All |
18 Years and older (Adult, Senior) |
NCT03096314 |
PETAL02VIOLET 1U01HL123009 |
VIOLET |
April 27, 2017 |
December 2020 |
June 2021 |
March 30, 2017 |
May 19, 2017 |
|
- UCSF Fresno
Fresno, California, United States - Ronald Reagan UCLA Medical Center
Los Angeles, California, United States - UC Davis Medical Center
Sacramento, California, United States - (and 44 more...)
|
4 |
NCT02582957 |
Recruiting |
Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome |
- Acute Respiratory Distress Syndrome
|
|
Interventional |
Not Applicable |
- University of Minnesota - Clinical and Translational Science Institute
- United States Department of Defense
- University of Colorado, Denver
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Ventilator-free days (VFDs)
- All-cause mortality
- ICU-free days
- (and 3 more...)
|
916 |
All |
18 Years to 89 Years (Adult, Senior) |
NCT02582957 |
W81XWH-15-1-0504 |
SiVent |
April 2016 |
January 2020 |
January 2020 |
October 21, 2015 |
November 30, 2017 |
|
- UCSF Fresno Community Regional Medical Center
Fresno, California, United States - University of Southern California (LA County)
Los Angeles, California, United States - Stanford University
Palo Alto, California, United States - (and 7 more...)
|
5 |
NCT02978885 |
Recruiting |
Imaging of periOP Lung Injury |
- Acute Lung Injury
- Chronic Obstructive Pulmonary Disease (COPD)
|
- Radiation: SPECT-CT imaging
- Drug: AxV-128/Tc
|
Interventional |
Phase 2 |
- Columbia University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Correlation of AxV-128/Tc uptake and fibrinogen
- Correlation of AxV-128/Tc uptake and C-Reactive Protein (CRP)
- Correlation of AxV-128/Tc uptake and White Blood Cell (WBC) count
- (and 5 more...)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02978885 |
AAAR0395 1R01HL131960-01 |
|
October 2017 |
July 2018 |
July 2019 |
December 1, 2016 |
September 20, 2017 |
|
- Columbia University Medical Center
New York, New York, United States
|
6 |
NCT01780155 |
Recruiting |
Genes Associated With Bronchopulmonary Dysplasia and Retinopathy of Prematurity |
- Bronchopulmonary Dysplasia
- Retinopathy of Prematurity
- Prematurity
- Pulmonary Disease
|
|
Observational |
|
- National Institute of Environmental Health Sciences (NIEHS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Bronchopulmonary dysplasia; retinopathy of prematurity
|
3600 |
All |
Child, Adult, Senior |
NCT01780155 |
999913031 13-E-N031 |
|
January 29, 2013 |
July 15, 2018 |
July 15, 2018 |
January 30, 2013 |
January 10, 2018 |
|
- NIEHS, Research Triangle Park
Research Triangle Park, North Carolina, United States - Clinica Y Maternidad
Suizo, Argentina
|
7 |
NCT00183482 |
Recruiting |
Family Cognitive Behavioral Therapy for Preventing Depression in Children |
|
- Behavioral: Family Cognitive Behavioral Therapy (CBT)
- Behavioral: Depression Education
|
Interventional |
Not Applicable |
- Vanderbilt University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Depression, anxiety, and disruptive behavior problems in children; measured at baseline and Week 12
- Depression in parents; measured at baseline and Week 12
- Parenting skills of parents; measured at baseline and Week 12
- (and 2 more...)
|
750 |
All |
10 Years and older (Child, Adult, Senior) |
NCT00183482 |
R01MH069940 DDTR B4-ARD |
|
August 1, 2010 |
December 31, 2015 |
December 31, 2017 |
September 16, 2005 |
April 12, 2017 |
|
- Vanderbilt University
Nashville, Tennessee, United States
|
8 |
NCT02488174 |
Recruiting |
Prevention of Severe Acute Respiratory Failure in Patients With PROOFCheck |
- Respiratory Failure
- Multiple Organ Failure
|
|
Interventional |
Not Applicable |
- Albert Einstein College of Medicine, Inc.
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Hospital Mortality
- Hospital Length of Stay
- Organ Failure
- (and 2 more...)
|
3459 |
All |
18 Years and older (Adult, Senior) |
NCT02488174 |
UH2HL125119 |
PROOFcheck |
August 2015 |
January 2019 |
July 2019 |
July 2, 2015 |
January 12, 2018 |
|
- Mayo Clinic
Jacksonville, Florida, United States - Mayo Clinic
Rochester, Minnesota, United States - Montefiore Medical Center
Bronx, New York, United States
|
9 |
NCT03431493 |
Recruiting |
Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure |
- Respiratory Insufficiency
- Depression
- Rehabilitation
- Critical Care
|
- Behavioral: Behavioral Activation - Rehabilitation
|
Interventional |
Not Applicable |
- Johns Hopkins University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Feasibility measure per participant
- Total feasibility measure
- Feasibility measure/Assess loss to follow-up
- (and 14 more...)
|
54 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT03431493 |
IRB00143231 K23HL138206 |
BEHAB |
March 2, 2018 |
June 2021 |
June 2021 |
February 13, 2018 |
April 20, 2018 |
|
- Johns Hopkins University
Baltimore, Maryland, United States
|
10 |
NCT02363686 |
Recruiting |
Aspiration in Acute Respiratory Failure Survivors |
|
- Procedure: FEES
- Procedure: BSE
|
Interventional |
Not Applicable |
- University of Colorado, Denver
- National Heart, Lung, and Blood Institute (NHLBI)
- Boston University
- National Institute of Nursing Research (NINR)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- To develop a BSE-based non-invasive clinical prediction rule (CPR) that will accurately and efficiently diagnose aspiration in ARF survivors.
- ICU and hospital length of stay, and length of stay after extubation
- Duration of mechanical ventilation
- (and 5 more...)
|
350 |
All |
18 Years and older (Adult, Senior) |
NCT02363686 |
12-0184 5K24HL089223 1R21NR015886-01 |
|
February 2012 |
May 2019 |
May 2019 |
February 16, 2015 |
May 4, 2017 |
|
- University of Colorado Hospital
Aurora, Colorado, United States - Yale University
New Haven, Connecticut, United States - Boston University Medical Center
Boston, Massachusetts, United States
|
11 |
NCT01937884 |
Recruiting |
Supplemental Parenteral Nutrition in Pediatric Respiratory Failure |
- Acute Respiratory Failure With Hypoxia
- Malnutrition
|
- Drug: Parenteral Nutrition
|
Interventional |
Phase 2 |
- University of Arizona
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- modified Prognostic Inflammatory and Nutritional Index (PINI)
- Percentage of daily goal calories achieved
- Organ failure free days
- (and 4 more...)
|
80 |
All |
1 Month to 16 Years (Child) |
NCT01937884 |
13-0374 5K12HD047349-09 |
SuPPeR |
August 2013 |
August 2018 |
August 2018 |
September 10, 2013 |
March 22, 2018 |
|
- University of Arizona Medical Center
Tucson, Arizona, United States
|
12 |
NCT02451228 |
Recruiting |
Indomethacin PK and PD Therapy in Pregnancy |
- Premature Labor
- Pregnancy
- Premature Birth
|
|
Observational |
|
- The University of Texas Medical Branch, Galveston
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Delivery <34 weeks gestation
- Preterm delivery <37, 32, and 28 weeks gestation
- Prolongation of pregnancy by 48 hours after enrollment (for sPTL)
- (and 20 more...)
|
300 |
Female |
18 Years and older (Adult, Senior) |
NCT02451228 |
15-0067 1R01HD083003-01 |
|
May 2015 |
May 2019 |
May 2019 |
May 21, 2015 |
March 1, 2018 |
|
- University of Alabama
Birmingham, Alabama, United States - University of Mississippi Medical Center
Jackson, Mississippi, United States - Columbia University
New York, New York, United States - (and 3 more...)
|
13 |
NCT01376778 |
Recruiting |
A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) |
- Congenital Cytomegalovirus Infection
- Maternal Cytomegalovirus Infection
|
- Drug: CMV hyperimmune globulin
- Other: Placebo
|
Interventional |
Phase 3 |
- The George Washington University Biostatistics Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Composite Outcome
- Gestational hypertension
- Preeclampsia
- (and 25 more...)
|
800 |
Female |
Child, Adult, Senior |
NCT01376778 |
HD36801-CMV U10HD036801 U10HD027869 U10HD027915 U10HD034116 U10HD034208 U10HD040500 U10HD040485 U10HD040544 U10HD040545 U10HD040560 U10HD040512 U10HD053097 U10HD068282 U10HD068258 U10HD068268 |
CMV |
April 2012 |
May 2018 |
December 2018 |
June 20, 2011 |
July 21, 2017 |
|
- University of Alabama - Birmingham
Birmingham, Alabama, United States - Stanford University
Stanford, California, United States - University of Colorado Denver
Aurora, Colorado, United States - (and 13 more...)
|
14 |
NCT01977547 |
Recruiting |
Age of Blood in Children in Pediatric Intensive Care Units |
|
- Biological: Short storage RBC age
|
Interventional |
Phase 3 |
- Washington University School of Medicine
- National Heart, Lung, and Blood Institute (NHLBI)
- Canadian Institutes of Health Research (CIHR)
- Ministere de la Sante et des Services Sociaux
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- New or Progressive Multiple Organ Dysfunction Syndrome (NPMODS)
- Organ dysfunction
- PELOD-2 score
- (and 7 more...)
|
1538 |
All |
up to 15 Years (Child) |
NCT01977547 |
201302030 1U01HL116383-01 MOP 126113 |
ABC PICU |
January 2014 |
May 2018 |
August 2018 |
November 6, 2013 |
April 6, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Diamond Children's Medical Center
Tucson, Arizona, United States - Children's Hospital Los Angeles
Los Angeles, California, United States - (and 39 more...)
|
15 |
NCT03364491 |
Recruiting |
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean |
- Obstetrical Complications
- Hemorrhage
- Labor and Delivery
|
- Drug: Tranexamic Acid
- Drug: Placebo
|
Interventional |
Phase 3 |
- The George Washington University Biostatistics Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Maternal death or transfusion of packed red blood cells
- Estimated blood loss
- Composite of surgical or radiological interventions to control bleeding and related complications, or maternal death
- (and 18 more...)
|
11000 |
Female |
18 Years and older (Adult, Senior) |
NCT03364491 |
HD36801-TXA U10HD036801 |
TXA |
March 12, 2018 |
December 2020 |
December 2020 |
December 6, 2017 |
April 20, 2018 |
|
- University of Alabama - Birmingham
Birmingham, Alabama, United States - Northwestern University-Prentice Hospital
Chicago, Illinois, United States - Columbia University
New York, New York, United States - (and 9 more...)
|
16 |
NCT02637427 |
Recruiting |
Does Plasma Reduce Bleeding in Patients Undergoing Invasive Procedures |
- Blood Coagulation Disorders
- Hemorrhage
|
- Biological: Fresh frozen plasma transfusion
|
Interventional |
Phase 3 |
- Rutgers, The State University of New Jersey
- University of Pittsburgh
- Johns Hopkins University
- (and 2 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Hemoglobin Level
- Trial Feasibility (Rates of eligible and enrolled study subjects)
- Red Blood Cell Transfusion
- (and 9 more...)
|
110 |
All |
21 Years and older (Adult, Senior) |
NCT02637427 |
Pro20150001801 1R34HL125804-01A1 |
|
January 2016 |
April 2019 |
May 2019 |
December 22, 2015 |
May 23, 2017 |
|
- Johns Hopkins University, The Johns Hopkins Hospital
Baltimore, Maryland, United States - Robert Wood Johnson University Hospital
New Brunswick, New Jersey, United States
|