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Rank Status Study
1 Recruiting Study of Gene Therapy Using a Lentiviral Vector to Treat X-linked Chronic Granulomatous Disease
Condition: Granulomatous Disease, Chronic, X-linked
Intervention: Biological: Lentiviral G1XCGD Gene Therapy
2 Withdrawn Lentiviral Gene Therapy for X-Linked Chronic Granulomatous Disease (X-CGD)
Condition: Granulomatous Disease, Chronic, X-linked, Variant
Intervention: Genetic: pCCLchimGp91s lentiviral vector transduced CD34+ cells infusion
3 Recruiting Gene Therapy for X-linked Chronic Granulomatous Disease
Condition: X-Linked Chronic Granulomatous Disease
Intervention: Genetic: X vivo gene therapy
4 Recruiting Gene Therapy for X-linked Chronic Granulomatous Disease (X-CGD)
Condition: X-Linked Chronic Granulomatous Disease
Intervention: Genetic: X vivo gene therapy
5 Terminated Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
Conditions: Immunologic Deficiency Syndromes;   Chediak-Higashi Syndrome;   Common Variable Immunodeficiency;   Graft Versus Host Disease;   X-Linked Lymphoproliferative Syndrome;   Familial Erythrophagocytic Lymphohistiocytosis;   Hemophagocytic Lymphohistiocytosis;   X-linked Agammaglobulinemia;   Wiskott-Aldrich Syndrome;   Chronic Granulomatous Disease;   X-linked Hyper IgM Syndrome;   Severe Combined Immunodeficiency;   Leukocyte Adhesion Deficiency Syndrome;   Virus-Associated Hemophagocytic Syndrome
Interventions: Drug: anti-thymocyte globulin;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: etoposide;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: prednisone;   Procedure: Allogeneic Bone Marrow Transplantation
6 Completed Gene Therapy for X-linked Chronic Granulomatous Disease (CGD) in Children
Condition: Chronic Granulomatous Disease
Intervention: Genetic: retroviral SF71-gp91phox transduced CD34+ cells
7 Recruiting Immune Disorder HSCT Protocol
Conditions: Immune Deficiency Disorders:;   Severe Combined Immunodeficiency;   Chronic Granulomatous Disease;   X-linked Agammaglobulinemia;   Wiskott-Aldrich Syndrome;   Hyper-IgM;   DiGeorge Syndrome;   Chediak-Higashi Syndrome;   Common Variable Immune Deficiency;   Immune Dysregulatory Disorder:;   Hemophagocytic Lymphohistiocytosis;   IPEX;   Autoimmune Lymphoproliferative Syndrome;   X-linked Lymphoproliferative Syndrome
Intervention: Drug: Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
8 Recruiting High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease
Condition: X-Linked Chronic Granulomatious Disease
Interventions: Drug: Campath;   Drug: Busulfan;   Other: allogeneic peripheral blood allograft infusion;   Drug: cyclophosphamide
9 Terminated
Has Results
Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells
Conditions: Stem Cell Transplantation;   Bone Marrow Transplantation;   Peripheral Blood Stem Cell Transplantation;   Allogeneic Transplantation,;   Genetic Diseases;   Thalassemia;   Pediatrics;   Diamond-Blackfan Anemia;   Combined Immune Deficiency;   Wiskott-Aldrich Syndrome;   Chronic Granulomatous Disease;   X-linked Lymphoproliferative Disease;   Metabolic Diseases
Interventions: Drug: Cyclophosphamide Dose Level 1;   Drug: Cyclophosphamide Dose Level 2;   Drug: Cyclophosphamide Dose Level 3;   Drug: Cyclophosphamide Dose Level 4
10 Recruiting Gene Therapy for X-CGD
Condition: X-linked Chronic Granulomatous Disease
Intervention: Genetic: ex-vivo gene-therapy
11 Unknown  Gene Therapy for Chronic Granulomatous Disease
Condition: Granulomatous Disease, Chronic
Intervention: Drug: retroviral SF71-gp91phox transduced CD34+ cells
12 Recruiting Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies
Conditions: SCID;   Omenn's Syndrome;   Reticular Dysgenesis;   Wiskott-Aldrich Syndrome;   Bare Lymphocyte Syndrome;   Common Variable Immunodeficiency;   Chronic Granulomatous Disease;   CD40 Ligand Deficiency;   Hyper IgM Syndrome;   X-linked Lymphoproliferative Disease;   Hemophagocytic Lymphohistiocytosis;   Griscelli Syndrome;   Chediak-Higashi Syndrome;   Langerhan's Cell Histiocytosis
Interventions: Drug: Alemtuzumab 0.3 mg;   Drug: Cyclophosphamide;   Drug: Busulfan;   Biological: Stem Cell Transplantation;   Drug: Fludarabine phosphate 40 mg;   Drug: Melphalan;   Drug: Alemtuzumab 0.2 mg;   Drug: Fludarabine phosphate 30 mg;   Drug: MESNA
13 Terminated Gene Therapy for Chronic Granulomatous Disease
Condition: Chronic Granulomatous Disease
Intervention: Drug: Phagocyte Oxidase Subunit Transduced CD34 Hematopoietic Stem Cells
14 Recruiting Patients Treated for Chronic Granulomatous Disease (CGD) Since 1995
Condition: Granulomatous Disease, Chronic
15 Unknown  Chronic Granulomatous Disease Study in China
Condition: Granulomatous Disease, Chronic
16 Completed Gene Therapy for Chronic Granulomatous Diseases - Long-term Follow-up
Conditions: Chronic Granulomatous Disease;   Communicable Disease
Interventions: Drug: Gene Therapy Method for CGD;   Device: Isolex 300i Magnetic Cell Selector
17 Completed Treatment of Chronic Granulomatous Disease With Allogeneic Stem Cell Transplantation Versus Standard of Care
Condition: Chronic Granulomatous Disease
Intervention: Drug: T-Cell Depleted & CD34+Select/w/StemCell Enriched Product
18 Active, not recruiting Gene Therapy for Chronic Granulomatous Disease in Korea
Condition: Chronic Granulomatous Disease
Intervention: Drug: VM106
19 Terminated Assessment of the Biochemical Response to Interferon-Gamma in Subjects With Specific Gene Mutation in Chronic Granulomatous Disease
Conditions: IFN-Gamma Therapy;   CGD Gene Mutation;   CGD Response to IFNg;   Chronic Granulomatous Disease;   Immunodeficiency Disease
Intervention: Drug: IFN-gamma
20 Completed Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous Disease
Condition: Chronic Granulomatous Disease
Interventions: Device: Nexell Isolex with T-cell Depletion;   Device: Baxter isolex 300i

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Indicates status has not been verified in more than two years