| 1 |
NCT03781635 |
Recruiting |
Comparison of BIS Index Variations: Bolus Versus Infusion Ketamine, and Impact on the Anesthesia Gas Consumption |
- Bolus Versus Infusion Ketamine, Anesthesia Gas Consumption
|
- Drug: bolus of intravenous ketamine
- Drug: continuous infusion of intravenous ketamine
|
Interventional
|
Phase 4 |
- Ciusss de L'Est de l'Île de Montréal
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Evaluation of the increase of the BIS index (absolute value between 0 to 100) after each intravenous ketamine bolus
- Area under the curve of BIS values from T0=incision until end of the anesthesia, value without unit (area under curve)
- Time for BIS to return within 10% of the baseline values (in minutes)
- (and 11 more...)
|
50 |
All |
18 Years and older (Adult, Older Adult) |
NCT03781635 |
2018-1482 |
KETABIS |
September 25, 2018 |
July 2019 |
December 2019 |
December 20, 2018 |
December 20, 2018 |
|
- Hopital Maisonneuve Rosemont, CIUSSS de l'Est de l'Ile de Montreal
Montréal-Est, Quebec, Canada
|
|
| 2 |
NCT02935595 |
Active, not recruiting |
Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients |
- Treatment Resistant Depression
|
|
Interventional
|
Phase 2 |
- The University of Texas Health Science Center, Houston
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Cortical Excitability in DLPFC using TMS-EEG
- Reduction in severity of depressive symptoms will be measured using the Montgomery-Asberg Depression Rating Scale (MADRS)
- Safety as indicated by number of adverse events
|
20 |
All |
18 Years to 60 Years (Adult) |
NCT02935595 |
HSC-MS-16-0705 |
ketamine |
September 2016 |
September 2019 |
September 2019 |
October 17, 2016 |
May 4, 2018 |
|
- Harris County Psychiatric Center
Houston, Texas, United States
|
|
| 3 |
NCT03525912 |
Recruiting |
Neuropsychiatric and Cardiovascular Side Effects in Ketamine Analgesic Infusions |
- Pain, Postoperative
- Ketamine Adverse Reaction
|
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Delirium
- Agitation
- Sedation
|
240 |
All |
18 Years and older (Adult, Older Adult) |
NCT03525912 |
UdeA1002 |
|
July 1, 2017 |
July 31, 2018 |
August 30, 2018 |
May 16, 2018 |
May 16, 2018 |
|
- hospital universitario San Vicente Fundacion
Medellin, Antioquia, Colombia
|
|
| 4 |
NCT03450499 |
Recruiting |
Analgesia Effects of Intravenous Ketamine After Spinal Anesthesia for Non-elective Cesarean Section |
- Non Elective Cesarean Section and Ketamine Analgesia
|
- Drug: Ketamine
- Drug: Placebo
|
Interventional
|
Phase 4 |
- B.P. Koirala Institute of Health Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Total opioid requirement postoperatively
- Postoperative numerator rating scores(NRS)up to 24 hrs . postoperative )
- Time to first perception of pain
- Incidence of side effects
|
80 |
Female |
18 Years to 35 Years (Adult) |
NCT03450499 |
IRC/1089/017 |
|
April 1, 2018 |
March 2019 |
April 2019 |
March 1, 2018 |
September 19, 2018 |
|
- BP Koirala Institute of Health Sciences (BPKIHS)
Dharān Bāzār, Koshi, Nepal
|
|
| 5 |
NCT03502551 |
Not yet recruiting |
ED Treatment of Suicidal Patients With Ketamine Infusion |
|
|
Interventional
|
Phase 2 |
- University of California, Davis
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Suicidal ideation at 24 hours post-infusion
- Incidence of Discharge to Outpatient vs. Inpatient Facilities
- Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
- (and 4 more...)
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT03502551 |
1197884 |
|
February 1, 2019 |
April 30, 2019 |
June 30, 2019 |
April 18, 2018 |
January 15, 2019 |
|
- University of California Davis Medical Center
Sacramento, California, United States
|
|
| 6 |
NCT03146806 |
Recruiting |
Intranasal (NAS) Ketamine for Cancer Pain |
|
- Drug: Intranasal ketamine
|
Interventional
|
Phase 1
Phase 2 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Bioavailability of intranasal (NAS) ketamine
- Peak concentration (Cmax) of intranasal (NAS) ketamine
- Elimination of intranasal (NAS) ketamine
- (and 20 more...)
|
25 |
All |
18 Years and older (Adult, Older Adult) |
NCT03146806 |
IRB00086610 |
|
July 25, 2017 |
June 1, 2019 |
October 1, 2019 |
May 10, 2017 |
November 20, 2018 |
|
- Winship Cancer Institute
Atlanta, Georgia, United States
|
|
| 7 |
NCT03272698 |
Recruiting |
ECT With Ketamine Anesthesia vs High Intensity Ketamine With ECT Rescue for Treatment-Resistant Depression |
- Treatment Resistant Depression
- Ketamine
|
- Drug: Ketamine
- Procedure: ECT
|
Interventional
|
Phase 4 |
- University of Saskatchewan
- Royal University Hospital Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Number of treatments required to reach disease remission
- Rate of rescue ECT in the HIKER arm
- Suicidal ideation
- (and 3 more...)
|
62 |
All |
18 Years and older (Adult, Older Adult) |
NCT03272698 |
123456 |
|
September 1, 2017 |
June 30, 2019 |
June 30, 2019 |
September 5, 2017 |
April 3, 2018 |
|
- Royal University Hospital
Saskatoon, Saskatchewan, Canada
|
|
| 8 |
NCT03338205 |
Not yet recruiting |
The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus |
|
|
Interventional
|
Phase 3 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Efficacy of ketamine in status asthmaticus by assessing change in clinical asthma score (CAS)
|
20 |
All |
2 Years to 18 Years (Child, Adult) |
NCT03338205 |
51152 |
|
July 2018 |
July 2019 |
January 2020 |
November 9, 2017 |
November 9, 2017 |
|
|
|
| 9 |
NCT03362073 |
Recruiting |
Continuous IntraVenous Infusion of Ketamine in Terminally Ill Cancer Patients |
- Ketamine
- Refractory Cancer Pain
|
|
Interventional
|
Phase 2 |
- Pusan National University Yangsan Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Overall response rate
- Change of pain intensity
- Rescue analgesics for breakthrough pain
- (and 5 more...)
|
26 |
All |
18 Years and older (Adult, Older Adult) |
NCT03362073 |
CIVIK |
CIVIK |
June 1, 2018 |
December 31, 2019 |
December 31, 2019 |
December 5, 2017 |
September 3, 2018 |
|
- Pusan National University Yangsan Hospital
Yangsan, Gyeongsangnam-do, Korea, Republic of
|
|
| 10 |
NCT02183272 |
Unknown † |
Emergency Ketamine Treatment of Suicidal Ideation |
- Depression
- Suicidal Ideation
- Suicidal Impulses
|
- Drug: Intranasal Ketamine
- Drug: Intranasal Saline Placebo
|
Interventional
|
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Ketamine effect on Suicidal Ideation and Depression.
- Assessment of Role of Mu Opioid Receptor
|
60 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02183272 |
Ketamine IIT |
|
August 2016 |
November 2017 |
July 2018 |
July 8, 2014 |
August 5, 2016 |
|
- University of Cincinnati
Cincinnati, Ohio, United States
|
|
| 11 |
NCT03357055 |
Not yet recruiting |
Ketamine Reduces Tourniquet Pain In Patients Undergoing Lower Limb Surgery Under Spinal Anaesthesia |
|
- Drug: Ketamine
- Drug: Normal saline
|
Interventional
|
Phase 4 |
- Dr Foo Li Lian
- University of Malaya
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in pain scores among patients in ketamine group vs patients in saline group, for patients undergoing lower limb surgery under spinal anaesthesia.
- Change in blood pressure in ketamine group vs saline group, for patients undergoing lower limb surgery under spinal anaesthesia.
|
60 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03357055 |
NMRR-17-2459-34013. |
|
December 13, 2017 |
March 2018 |
March 2018 |
November 29, 2017 |
December 13, 2017 |
|
|
|
| 12 |
NCT03525821 |
Recruiting |
Intranasal Ketamine and Fracture Reduction in Pediatric Emergencies (KETAPED) |
|
- Drug: Ketamine Hydrochloride
|
Interventional
|
Phase 3 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- effectiveness evaluation of ketamine by measure the change of pain control
- evaluation of the degree of sedation
- evaluation of tolerance
- (and 3 more...)
|
60 |
All |
4 Years to 17 Years (Child) |
NCT03525821 |
17-HPNCL-01 |
KETAPED |
July 5, 2018 |
June 2019 |
January 2020 |
May 16, 2018 |
July 30, 2018 |
|
- Hôpitaux pédiatriques de Nice CHU-Lenval
Nice, France
|
|
| 13 |
NCT02094898 |
Completed
Has Results |
Ketamine for Depression and Suicide Risk |
|
|
Interventional
|
Phase 2 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- MADRS Total Score at Baseline and Last Acute Phase Observation
- MADRS Total Score, Percent Change From Baseline at Last Acute Phase Observation
- MADRS Factor 1 Score at Baseline and Last Acute Phase Observation
- (and 11 more...)
|
12 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02094898 |
13-005152 |
Ketamine |
September 2014 |
July 2016 |
August 2016 |
March 24, 2014 |
August 11, 2017 |
August 11, 2017 |
- Mayo Clinic
Rochester, Minnesota, United States
|
|
| 14 |
NCT03053947 |
Recruiting |
Pain Free Laceration Repairs Using Intra-nasal Ketamine |
|
- Drug: Intranasal Ketamine
|
Interventional
|
Phase 2 |
- Evelyne D.Trottier
- St. Justine's Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Optimal doses of intranasal ketamine for adequate procedural sedation as assessed by the PERC/PECARN consensus criteria for procedural sedation in children during their laceration repair.
- Pain before, during and after the procedure assessed with the Faces pain scale Revised for children older than 4 year-old and with the Face Legs Activity Cry Consolability (FLACC) score for children younger than 4 year-old.
- Anxiety before, during and after the procedure assessed with the Procedure behavioural rating revised scale.
- (and 3 more...)
|
40 |
All |
1 Year to 12 Years (Child) |
NCT03053947 |
2017-1149 |
|
February 16, 2017 |
June 2019 |
June 2020 |
February 15, 2017 |
May 8, 2018 |
|
- Sickkids
Toronto, Ontario, Canada - St. Justine's Hospital
Montreal, Quebec, Canada
|
|
| 15 |
NCT02397356 |
Withdrawn |
Inhaled Nebulised S(+)-Ketamine for Postoperative Analgesia |
|
- Drug: Ketamine first AB
- Drug: Placebo first BA
|
Interventional
|
Phase 4 |
- Tampere University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Potential of S(+)-ketamine as an analgesic in the nebulised form
- Duration of analgesia
- Duration of need for PACU care
|
0 |
Male |
18 Years to 65 Years (Adult, Older Adult) |
NCT02397356 |
R14066M
2014-000837-22 |
|
August 2018 |
December 2020 |
December 2020 |
March 24, 2015 |
August 28, 2018 |
|
- Tampere University Hospital
Tampere, Finland
|
|
| 16 |
NCT03086148 |
Recruiting |
Ketamine and Postoperative Depressive Symptom |
- Ketamine; Depressive Symptom; Neurosurgery; Perioperative Period
|
- Drug: Ketamine
- Drug: Normal saline
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Perioperative depression symptom (PDS)
- The remission rate of perioperative depression symptom (PDS)
- Perioperative anxiety symptom
- (and 7 more...)
|
80 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03086148 |
2017-03-16 |
|
July 5, 2017 |
December 2018 |
February 2019 |
March 22, 2017 |
April 12, 2018 |
|
- Beijing TianTan Hospital
Beijing, China
|
|
| 17 |
NCT03553758 |
Recruiting |
EEG Studies of Ketamine General Anesthesia |
|
|
Interventional
|
Phase 2
Phase 3 |
- Massachusetts General Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- EEG power at ketamine-included loss of responsiveness
|
15 |
All |
18 Years to 45 Years (Adult) |
NCT03553758 |
2018P000417 |
|
November 1, 2018 |
November 2019 |
November 2019 |
June 12, 2018 |
January 8, 2019 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 18 |
NCT01669642 |
Completed
Has Results |
Study to Find the Dose of Rapidly Administered Ketamine for Brief Painful Procedures in Children |
|
|
Interventional
|
Not Applicable |
- Washington University School of Medicine
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- to Find the Median Effective Dose (ED50) and ED95 of Rapidly Administered Ketamine
- ED95
- Vomiting
- Number of Participants With Wisconsin Sedation Scale Score of 2 or Less at 1 Minute After First Dose of Ketamine
|
111 |
All |
2 Years to 17 Years (Child) |
NCT01669642 |
201112017 |
|
April 2012 |
August 2014 |
August 2014 |
August 21, 2012 |
March 12, 2018 |
March 12, 2018 |
- St Louis Children's hospital, Washington university
Saint Louis, Missouri, United States
|
|
| 19 |
NCT03067974 |
Terminated |
Intranasal Ketamine for Pediatric Procedural Sedation: a Feasibility Study |
- Failed Moderate Sedation During Procedure
- Ketamine Adverse Reaction
|
- Drug: Ketamine Hcl 100Mg/Ml Inj
|
Interventional
|
Early Phase 1 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Successful procedural sedation
|
10 |
All |
2 Years to 7 Years (Child) |
NCT03067974 |
1705414419 |
|
September 21, 2017 |
January 22, 2019 |
January 22, 2019 |
March 1, 2017 |
January 28, 2019 |
|
- Banner Univsersity Medical Center Tucson
Tucson, Arizona, United States
|
|
| 20 |
NCT02544607 |
Completed |
Ketamine for Depression: An MRI Study |
- Depression
- Anxious Depression
- Major Depressive Disorder
|
|
Interventional
|
Phase 4 |
- Massachusetts General Hospital
- Brain & Behavior Research Foundation
- National Institutes of Health (NIH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change in Hamilton Depression Rating Scale (HDRS) from Baseline/Minute 0 to 4 hours post-infusion.
|
25 |
All |
18 Years to 64 Years (Adult) |
NCT02544607 |
2015P001912 |
|
March 2016 |
December 29, 2017 |
December 29, 2017 |
September 9, 2015 |
March 21, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 21 |
NCT01945047 |
Completed |
Action of Ketamine in Treatment-Resistant Depression |
- Treatment-resistant Depression
|
- Drug: Ketamine
- Drug: Midazolam
|
Interventional
|
Phase 2
Phase 3 |
- University of Ottawa
- Canadian Institutes of Health Research (CIHR)
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Efficacy of Ketamine over Midazolam in double blind study for efficacy of relief for Major Depressive Disorder
- Ketamine for use in relief of Major Depressive Disorder over repeated administration
- To determine the role of genetic polymorphisms in the participants response to ketamine infusion
|
46 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01945047 |
REB2012023 |
|
May 2013 |
December 2017 |
December 2017 |
September 18, 2013 |
June 25, 2018 |
|
- Institute of Mental Health Research, Royal Ottawa Hospital
Ottawa, Ontario, Canada
|
|
| 22 |
NCT01988922 |
Completed
Has Results |
CYP2B6 Polymorphisms in Ketamine |
|
|
Interventional
|
Not Applicable |
- Washington University School of Medicine
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- The Effects of CYP2B6 Genetic Variants on Ketamine Metabolism and Clearance by CYP2B6*6 Hetero or Homozygote Genotype.
|
30 |
All |
18 Years to 50 Years (Adult) |
NCT01988922 |
201307034 |
|
November 2013 |
May 2016 |
May 2017 |
November 20, 2013 |
May 18, 2018 |
May 18, 2018 |
- Washington University School of Medicine
Saint Louis, Missouri, United States
|
|
| 23 |
NCT03666390 |
Recruiting |
Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide |
- Major Depressive Disorder
|
- Drug: Ketamine
- Drug: Midazolam
|
Interventional
|
Not Applicable |
- Taipei Veterans General Hospital, Taiwan
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Reduction rate of suicide symptom
- Reduction rate of depression symptom
|
48 |
All |
20 Years to 65 Years (Adult, Older Adult) |
NCT03666390 |
107-2314-B-075-063-MY3 |
|
September 10, 2018 |
December 31, 2021 |
December 31, 2021 |
September 11, 2018 |
September 19, 2018 |
|
- Taipei Veterans General Hospital
Taipei, Taiwan
|
|
| 24 |
NCT03336541 |
Completed |
Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression |
- Perinatal Depression
- Ketamine
- Cesarean Delivery
- Postpartum Depression
|
- Drug: Ketamine
- Drug: Placebo
|
Interventional
|
Phase 4 |
- Peking University First Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- The score of postpartum depression at 48 hous after childbirth.
- Time of first breast feeding.
- The proportion of neonates with breast feeding.
- (and 6 more...)
|
64 |
Female |
18 Years to 45 Years (Adult) |
NCT03336541 |
2017[36] |
|
November 23, 2017 |
May 14, 2018 |
June 25, 2018 |
November 8, 2017 |
August 7, 2018 |
|
- Department of Anesthesiology and Critical Care Medicine, Peking University First Hospital
Beijing, Beijing, China
|
|
| 25 |
NCT02916927 |
Completed |
Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department |
|
- Drug: Ketamine IV Infusion
- Drug: Ketamine IV push
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Side effects
- Side effect severity
- How bothersome are the side effects?
- Reduction in pain
|
56 |
All |
18 Years and older (Adult, Older Adult) |
NCT02916927 |
00002 |
|
September 2016 |
April 2017 |
April 2017 |
September 28, 2016 |
May 5, 2017 |
|
- Alameda Health System, Highland Hospital
Oakland, California, United States
|
|
| 26 |
NCT02016664 |
Completed |
Plasma Concentration of Ketamine and Norketamine . |
|
|
Interventional
|
Not Applicable |
- Lawson Health Research Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Plasma level of oral ketamine and norketamine at two different doses.
- Mean Pain Score
|
12 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02016664 |
OKPCS |
|
April 2014 |
December 2015 |
December 2015 |
December 20, 2013 |
March 1, 2016 |
|
- St.Joseph's Health Care, Western University
London, Ontario, Canada
|
|
| 27 |
NCT03742557 |
Recruiting |
Evaluation of Schemes of Administration of Intravenous Ketamine in Depression |
- Treatment Resistant Depression
|
- Drug: Ketamine 50 MG/ML Injectable Solution, 0.5 mg/kg IV
|
Interventional
|
Phase 3 |
- National Institute of Neurology and Neurosurgery, Mexico
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Depression Severity Hamilton Depression Rating Scale
- Glutamate
- GABA
- Depression Severity Montgomery-Asberg Depression Rating Scale)
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03742557 |
74/18 |
|
October 1, 2018 |
January 1, 2020 |
January 1, 2020 |
November 15, 2018 |
November 15, 2018 |
|
- Instituto Nacional de Neurología y Neurocirugía (National Institute of Neurology and Neurosurgery)
Mexico City, Tlalpan, Mexico
|
|
| 28 |
NCT03502421 |
Withdrawn |
Ketamine Sickle Cell Disease |
|
|
Interventional
|
Phase 3 |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Total opioid Use in milligrams morphine equivalents
- Pain scores measured on the Visual Analog Scale 0 - 10
- Cost of pharmacotherapy
- (and 2 more...)
|
0 |
All |
18 Years and older (Adult, Older Adult) |
NCT03502421 |
Pro00033576 |
SCD |
September 1, 2018 |
September 1, 2019 |
November 1, 2019 |
April 18, 2018 |
September 26, 2018 |
|
|
|
| 29 |
NCT03434366 |
Recruiting |
Intranasal Ketamine With Dexmedetomidine for the Treatment of Children With Autism Spectrum Disorder |
|
- Drug: ketamine and dexmedetomidine
- Drug: ketamine
- Drug: Saline
|
Interventional
|
Phase 2 |
- Guangzhou Women and Children's Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Autism Diagnostic Interview Revised (ADI-R)
- Autism Diagnostic Observation Schedule (ADOS)
- autism behavior checklist (ABC)
- (and 2 more...)
|
50 |
All |
2 Years to 15 Years (Child) |
NCT03434366 |
intranasal ketamine |
|
January 20, 2018 |
May 30, 2019 |
June 30, 2019 |
February 15, 2018 |
July 11, 2018 |
|
- Guangzhou Women and Children Medical Center
Guangzhou, Guangdong, China
|
|
| 30 |
NCT02501941 |
Completed |
Spreading Depolarization and Ketamine Suppression |
- Cortical Spreading Depolarization
- Cortical Spreading Depression
- Subarachoid Hemorrhage
- Traumatic Brain Injury
|
|
Interventional
|
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in frequency of Cortical Spreading depression with use of ketamine
- Change in frequency of Cortical Spreading depolarization with stimulation to patient
- Change in frequency of Cortical Spreading depolarization with varying doses of ketamine
- (and 5 more...)
|
10 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02501941 |
15-056 |
SAKS |
July 2015 |
January 1, 2017 |
May 1, 2017 |
July 17, 2015 |
October 25, 2017 |
|
- University of New Mexico
Albuquerque, New Mexico, United States
|
|
| 31 |
NCT02418702 |
Unknown † |
A Study to Decrease Suicidal Thinking Using Ketamine |
|
- Drug: 0.2 mg/kg ketamine
- Other: placebo
|
Interventional
|
Phase 3 |
- United States Naval Medical Center, San Diego
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in baseline in depressive symptoms measured by Beck Scale for Suicide ideation (BSS), Beck Hopelessness Scale (BHS), and Beck Depression Index (BDI)
- Reduction in suicidal thinking measured by BSS, BHS, and BDI
|
40 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02418702 |
NMCSD.2014.0031 |
|
December 2016 |
June 2017 |
June 2018 |
April 16, 2015 |
August 22, 2016 |
|
- Naval Medical Center San Diego
San Diego, California, United States
|
|
| 32 |
NCT03375671 |
Recruiting |
Rapid Agitation Control With Ketamine in the Emergency Department |
- Violent Aggressive Behavior
- Ketamine
|
- Drug: Ketalar
- Drug: Midazolam injection
- Drug: Haloperidol
|
Interventional
|
Phase 2 |
- David Barbic
- St Paul's Emergency Department Research Fund
- Centre for Health Evaluation and Outcome Sciences (CHÉOS)
- University of British Columbia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time from first IM medication administration to adequate sedation which is defined as RASS less than or equal to -1.
- Percentage participants with adverse events in each arm
- Percentage of participants in each arm requiring rescue medications between 5 and 30 minutes (at 5 minutes interval) after study medication(s) administration by count.
- (and 6 more...)
|
184 |
All |
19 Years to 60 Years (Adult) |
NCT03375671 |
H17-00571 |
RACKED |
May 29, 2018 |
April 1, 2019 |
April 1, 2020 |
December 18, 2017 |
July 18, 2018 |
|
- St. Paul's Hospital Emergency Department
Vancouver, British Columbia, Canada
|
|
| 33 |
NCT02303847 |
Unknown † |
Ultra-low Dose Oral Ketamine for Chronic Pain in the Primary Care Setting |
|
|
Interventional
|
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pain improvement (Brief Pain Inventory (BPI) Mean Pain Severity Scale)
- Function improvement (BPI Mean Interference Scale)
- Reduction in opioid use (self-reported average opioid dose)
|
32 |
All |
18 Years and older (Adult, Older Adult) |
NCT02303847 |
20141809 |
Ketamine |
November 2014 |
June 2015 |
June 2015 |
December 1, 2014 |
May 27, 2015 |
|
- Pioneer Family Practice
Lacey, Washington, United States
|
|
| 34 |
NCT03296345 |
Recruiting |
Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis |
- Sickle Cell Disease
- Vaso-Occlusive Crisis
|
|
Interventional
|
Phase 2 |
- Children's Hospital & Research Center Oakland
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]
- Effect of low-dose ketamine on opiate usage in the ED
- Effect of low-dose ketamine on pain scores in the ED
- (and 2 more...)
|
90 |
All |
8 Years to 25 Years (Child, Adult) |
NCT03296345 |
2010-010 |
AKTSS |
June 2016 |
January 2017 |
December 2018 |
September 28, 2017 |
September 28, 2017 |
|
- UCSF Benioff Children's Hospital and Research Center Oakland
Oakland, California, United States
|
|
| 35 |
NCT02669043 |
Terminated
Has Results |
Physiological and Cognitive Biomarkers for Ketamine's Antidepressant Effects |
|
|
Interventional
|
Not Applicable |
- Massachusetts General Hospital
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Hamilton Depression Rating Scale (HDRS, HAM-D)
|
8 |
All |
18 Years to 64 Years (Adult) |
NCT02669043 |
2015P002397
K23MH107776 |
|
July 2016 |
February 2017 |
February 2017 |
January 29, 2016 |
April 23, 2018 |
February 28, 2017 |
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 36 |
NCT02422303 |
Terminated
Has Results |
Effects of Low Dose Ketamine Given at Induction of Anesthesia on Postoperative Mood in Patients With Depressive Symptoms |
- Depression
- Major Depressive Disorder
|
|
Interventional
|
Not Applicable |
- The University of Texas Health Science Center at San Antonio
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Depression Score Using Goldberg Depression Screening Test
|
12 |
Female |
18 Years to 65 Years (Adult, Older Adult) |
NCT02422303 |
HSC20150248H |
|
December 2015 |
September 2016 |
September 2016 |
April 21, 2015 |
February 15, 2018 |
February 15, 2018 |
- University Hospital
San Antonio, Texas, United States
|
|
| 37 |
NCT03781817 |
Not yet recruiting |
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures |
- Trauma
- Fractures, Closed
- Children, Only
- (and 2 more...)
|
- Drug: Intravenous Ketamine
- Drug: Intranasal Ketamine
|
Interventional
|
Phase 4 |
- University of Alabama at Birmingham
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Achieved adequate sedation as evidenced by Modified Ramsay Sedation score.
- Percentage of adequately sedated participants successfully completing the procedure without requiring rescue medications.
- Proportions of patients with non-serious adverse events.
- (and 2 more...)
|
66 |
All |
1 Year to 18 Years (Child, Adult) |
NCT03781817 |
IRB-300002731 |
|
June 1, 2019 |
January 1, 2020 |
January 1, 2021 |
December 20, 2018 |
December 21, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States
|
|
| 38 |
NCT01868802 |
Unknown † |
Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican Population |
- Depressive Disorder,
- Treatment-Resistant Depression
|
- Drug: Ketamine
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Paul J. Lamothe
- American British Cowdray Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Changes in baseline HDRS Score
- Daily change in HDRS post-ketamine infusion.
- Baseline blood pressure (BP).
- Changes from baseline in blood pressure (BP)
|
60 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01868802 |
ABC KET-DRT-01-2013 |
|
September 2013 |
May 2016 |
|
June 5, 2013 |
March 17, 2015 |
|
- ABC Neurological Center
Mexico City, DF, Mexico
|
|
| 39 |
NCT02587130 |
Recruiting |
Ketamine and Refractory Painful Care in a Palliative Unit |
- Intractable Pain
- Intensive Care
- Pressure Ulcer
- Pain Management
|
|
Interventional
|
Phase 4 |
- Lille Catholic University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from Baseline in Pain Score on the Visual Analog Scale or Algoplus after subcutaneous bolus of Ketamine
- Number of secondary side effects after administration of a sub-cutaneous ketamine's bolus
- Ketamine dosage administered in sub-cutaneous bolus before painful caring
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT02587130 |
RC-P0041 |
KETAREF |
May 2016 |
November 2019 |
November 2019 |
October 27, 2015 |
November 21, 2018 |
|
|
|
| 40 |
NCT02836288 |
Completed |
Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for Cancer |
|
- Drug: Ketamine
- Other: Placebo
|
Interventional
|
Early Phase 1 |
- Scott A. Irwin, MD, PhD
- Icahn School of Medicine at Mount Sinai
- Cedars-Sinai Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Proportion of patients pre-screened that were potentially eligible for study participation.
- Proportion of patients that were potentially eligible who were approached.
- Proportion of approached patients that decline study participation and why.
- (and 7 more...)
|
4 |
All |
18 Years and older (Adult, Older Adult) |
NCT02836288 |
IIT2015-23-IRWIN-KETTREAT |
|
December 20, 2016 |
May 29, 2018 |
May 29, 2018 |
July 19, 2016 |
November 6, 2018 |
|
- Cedars-Sinai Medical Center
Los Angeles, California, United States
|
|
| 41 |
NCT03473431 |
Not yet recruiting |
Effect of Ketamine in Depressive Symptoms of Elderly Patients With Visual Impairment. |
- Depression in Old Age
- Ketamine
|
- Drug: Ketamine
- Other: control
|
Interventional
|
Not Applicable |
- Instituto Mexicano del Seguro Social
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Depressive symptoms
- Depression rate
|
90 |
All |
60 Years and older (Adult, Older Adult) |
NCT03473431 |
IMexicanoSS |
|
March 30, 2018 |
June 30, 2018 |
July 30, 2018 |
March 22, 2018 |
March 22, 2018 |
|
|
|
| 42 |
NCT02219867 |
Unknown † |
Ketamine Infusions for Major Depression Disorder |
- Depressive Disorder, Major
|
|
Interventional
|
Not Applicable |
- Sheba Medical Center
- Tel Aviv University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Montgomery Asberg Rating scale - MADRS
- Side effects monitoring
|
10 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02219867 |
Sheba- Ketamine |
Ketamie |
August 2014 |
January 2016 |
August 2017 |
August 19, 2014 |
August 29, 2014 |
|
- Sheba MC
Ramat Gan, Israel
|
|
| 43 |
NCT03631875 |
Recruiting |
Co-induction Ketamine-propofol: Effects on Laryngeal Mask Airway Insertion Conditions in Children |
- Anesthesia Intubation Complication
|
|
Interventional
|
Phase 4 |
- University Hospital, Mahdia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- laryngale masque conditions insertion
- hemodynamic conditions
- heart rate
|
120 |
All |
1 Year to 8 Years (Child) |
NCT03631875 |
Ketco1 |
|
June 1, 2018 |
September 30, 2018 |
October 30, 2018 |
August 15, 2018 |
August 15, 2018 |
|
- Mahdia University Hospital
Mahdia, Tunisia
|
|
| 44 |
NCT03499886 |
Recruiting |
Low-Dose Intravenous Ketamine Bolus Versus Conventional Technique |
|
- Drug: Ketamine Hydrochloride 50Mg/1mL Solution for Injection
- Drug: Ketamine Hcl 50Mg/Ml Inj
|
Interventional
|
Phase 2
Phase 3 |
- Isfahan University of Medical Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
198 |
All |
6 Months to 17 Years (Child) |
NCT03499886 |
195027 |
|
January 17, 2017 |
April 28, 2018 |
May 14, 2018 |
April 17, 2018 |
April 17, 2018 |
|
- Al-Zahra University Hospital
Isfahan, Iran, Islamic Republic of - Mehdi Nasr Isfahani
Isfahan, Iran, Islamic Republic of
|
|
| 45 |
NCT01371110 |
Terminated
Has Results |
Intravenous Ketamine in the Treatment of Obsessive-Compulsive Disorder |
- Obsessive Compulsive Disorder
|
- Drug: Ketamine
- Drug: Midazolam
|
Interventional
|
Phase 1
Phase 2 |
- Wayne Goodman MD
- Icahn School of Medicine at Mount Sinai
- Baylor College of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in Yale-Brown Obsessive Compulsive Scale (Y-BOCCS) Rating OCD Symptom Severity From Baseline to 24-hours After Ketamine Administration
- Percentage of Patients Who Meet Response and Remission
|
3 |
All |
21 Years to 65 Years (Adult, Older Adult) |
NCT01371110 |
GCO 11-1113
HSM#11-01536 |
IVKetamine |
June 2012 |
June 2015 |
June 2015 |
June 10, 2011 |
January 18, 2018 |
October 2, 2017 |
- Clinical Research Centers at Icahn School of Medicine at Mount Sinai
New York, New York, United States
|
|
| 46 |
NCT02442739 |
Withdrawn |
Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck Cancers |
- Head and Neck Cancer
- Pancreatic Cancer
- Depression
|
- Drug: Ketamine
- Other: Placebo
|
Interventional
|
Early Phase 1 |
- Cedars-Sinai Medical Center
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Proportion of patients pre-screened that were potentially eligible for study participation.
- Proportion of patients that were potentially eligible who were approached.
- Proportion of approached patients that decline study participation and why.
- (and 7 more...)
|
0 |
All |
18 Years and older (Adult, Older Adult) |
NCT02442739 |
IIT2015-22-IRWIN-KETPREVE
1R21CA197023-01A1 |
|
August 15, 2016 |
November 3, 2017 |
November 3, 2017 |
May 13, 2015 |
November 6, 2018 |
|
- Cedars-Sinai Medical Center
Los Angeles, California, United States
|
|
| 47 |
NCT03256162 |
Completed |
Ketamine as an Adjunctive Therapy for Major Depression |
- Major Depressive Episode
- Unipolar Depression
- Bipolar Depression
|
- Drug: Ketamine
- Drug: Midazolam
|
Interventional
|
Phase 1 |
- St Patrick's Hospital, Ireland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- The Hamilton Rating Scale for Depression-24 item version (HRSD-24)
- The Quick Inventory of Depressive Symptoms, self-report version (QIDS-SR16)
- The Clinician-Administered Dissociative States Scale (CADSS)
- (and 4 more...)
|
25 |
All |
18 Years and older (Adult, Older Adult) |
NCT03256162 |
01/17
2016-004764-18 |
KARMA-dep |
September 7, 2017 |
September 21, 2018 |
September 21, 2018 |
August 21, 2017 |
November 27, 2018 |
|
- St Patrick's University Hospital
Dublin, Ireland
|
|
| 48 |
NCT02636218 |
Recruiting |
Ketamine Infusion in Neurologic Deficit |
|
- Drug: Ketamine
- Drug: 0.9% NaCl
|
Interventional
|
Phase 2
Phase 3 |
- Dr. Andrew Baker
- Defence Research and Development Canada
- St. Michael's Hospital, Toronto
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Changes in physiologic parameters as specified below
- Biologic samples
- Neurocognitive test Montreal Cognitive Assessment Scale (MoCA)
- (and 6 more...)
|
50 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02636218 |
KTM-3007 |
KIND |
January 2016 |
December 2018 |
February 2019 |
December 21, 2015 |
April 17, 2018 |
|
- St Michael's Hospital
Toronto, Ontario, Canada
|
|
| 49 |
NCT03788694 |
Recruiting |
Intranasal Ketamine for Suicidal Ideation in Veterans |
|
|
Interventional
|
Early Phase 1 |
- Bronx Veterans Medical Research Foundation, Inc
- Icahn School of Medicine at Mount Sinai
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Beck Scale for Suicidal Ideation (BSSI)
- Montgomery-Asberg Depression Rating Scale (MADRS)
- The Quick Inventory of Depressive Symptomatology, Self-Report (QIDS-SR)
|
15 |
All |
21 Years to 70 Years (Adult, Older Adult) |
NCT03788694 |
GOO-17-048 |
|
January 1, 2019 |
January 2020 |
April 2020 |
December 27, 2018 |
December 31, 2018 |
|
- James J. Peters VA Medical Center
Bronx, New York, United States
|
|
| 50 |
NCT03156504 |
Enrolling by invitation |
The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic Unipolar Major Depression and Bipolar I or II Depression. |
- Major Depression
- Bipolar I Disorder
- Bipolar II Disorder
- Unipolar Depression
|
- Drug: Ketamine Hydrochloride
|
Interventional
|
Phase 1 |
- Mayo Clinic
- National Network of Depression Centers
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in MÅDRS total score.
|
100 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03156504 |
16-009737 |
Bio-K |
June 1, 2017 |
December 2019 |
January 2020 |
May 17, 2017 |
March 5, 2018 |
|
- Johns Hopkins Hospital
Baltimore, Maryland, United States - University of Michigan
Ann Arbor, Michigan, United States - Mayo Clinic
Rochester, Minnesota, United States - University of Cincinnati Medical Center
Cincinnati, Ohio, United States
|
|
| 51 |
NCT02256358 |
Completed
Has Results |
Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation |
|
- Drug: Midazolam
- Drug: Ketamine
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
|
68 |
All |
2 Years to 6 Years (Child) |
NCT02256358 |
2012-127 |
|
January 2013 |
January 2014 |
January 2014 |
October 3, 2014 |
October 20, 2014 |
October 9, 2014 |
|
|
| 52 |
NCT02241278 |
Completed |
Preoperative Ketamine Has no Preemptive Analgesic Effect in Patients Undergoing Colon Surgery. |
|
|
Interventional
|
Phase 4 |
- Hospital Arquitecto Marcide
- Complexo Hospitalario Universitario de A Coruña
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Visual Analog Scale (VAS) score
- morphine consumption
|
48 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02241278 |
MK334037 |
|
September 2001 |
June 2002 |
June 2002 |
September 16, 2014 |
September 16, 2014 |
|
- Hospital Arquitecto Marcide
Ferrol, A Coruna, Spain
|
|
| 53 |
NCT01740492 |
Completed |
Low Dose Ketamine for Management of Acute Severe Pain in the Emergency Department |
|
- Drug: Ketamine 0.15mg/kg
- Drug: Ketamine 0.3mg/kg
- Other: Placebo
|
Interventional
|
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in reported pain score at 15 minutes, 30 minutes, and hourly for 6 hrs or until discharge
- Safety--Determine the incidence of adverse events associated with ketamine and morphine, versus morphine alone at 5 minutes, 30 minutes, and hourly up to 6 hours.
|
75 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01740492 |
298021 |
|
September 2012 |
June 2014 |
June 2014 |
December 4, 2012 |
November 2, 2015 |
|
- Rhode Island Hospital
Providence, Rhode Island, United States
|
|
| 54 |
NCT03511833 |
Not yet recruiting |
Comparison of Treatment by IN Ketamine to IV Morphine in Acute Pain |
|
- Drug: Morphine
- Drug: Ketamine
|
Interventional
|
Phase 3 |
- Tel-Aviv Sourasky Medical Center
- Medical Corps, Israel Defense Force
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Effectiveness of intranasal ketamine in decreasing pain intensity [patient assessed - VAS pain score] [ Time Frame: 2 hour post administration
- • adverse effects [Opiate Related Symptom Distress Scale] [ Time Frame: 2 hour post administration ]
- • patient satisfaction [Interview] [ Time Frame: 2 hours post administration ]
|
120 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03511833 |
TASMC-18-PH-0459-17-CTIL |
|
September 1, 2018 |
August 31, 2019 |
February 28, 2020 |
April 30, 2018 |
April 30, 2018 |
|
- Tel Aviv Sourasky Medical Center, department of Emergency Medicine
Tel Aviv, Israel
|
|
| 55 |
NCT03633058 |
Recruiting |
A Study to Evaluate Ketamine for the Treatment of Rett Syndrome |
|
|
Interventional
|
Phase 2 |
- Rett Syndrome Research Trust
- Vanderbilt University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Dose-Limiting Adverse Events
- Clinical Global Impression of Improvement
- Motor Behavioral Assessment
- (and 6 more...)
|
48 |
Female |
6 Years to 12 Years (Child) |
NCT03633058 |
Ket-101-RSRT |
|
February 2019 |
October 2019 |
December 2019 |
August 16, 2018 |
February 5, 2019 |
|
- University of Alabama Birmingham School of Medicine
Birmingham, Alabama, United States - Children's Hospital Colorado
Aurora, Colorado, United States - Center for Rare Neurological Diseases
Norcross, Georgia, United States - (and 4 more...)
|
|
| 56 |
NCT02402868 |
Completed |
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children |
|
- Drug: Ketamine and saline
|
Interventional
|
Phase 3 |
- Lawson Health Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- University of Michigan Sedation Score
- Onset of sedation
- Duration of sedation
- (and 13 more...)
|
17 |
All |
5 Years to 17 Years (Child) |
NCT02402868 |
106549 |
|
January 2016 |
January 2018 |
February 2018 |
March 30, 2015 |
August 14, 2018 |
|
- Children's Hospital, London Health Sciences Centre
London, Ontario, Canada
|
|
| 57 |
NCT02920528 |
Active, not recruiting |
Subdissociative Dose Ketamine for Treatment of Acute Pain in Subjects With Chronic Pain |
|
- Drug: Ketamine
- Drug: Placebo
|
Interventional
|
Phase 3 |
- Los Angeles Biomedical Research Institute
- Air Force Research Laboratory
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Compare pain relief between the 3 treatment groups as measured by the VAS. A decrease of at least 20mm on the VAS will be considered "significant" pain relief
- Compare total dosage of IV hydromorphone needed as rescue therapy to achieved adequate pain relief
- Assess the risk for complications of sub-dissociative dose ketamine
|
106 |
All |
18 Years and older (Adult, Older Adult) |
NCT02920528 |
30612-01 |
|
May 1, 2017 |
June 22, 2018 |
October 2018 |
September 30, 2016 |
July 6, 2018 |
|
- Emergency Department, Harbor-UCLA Medical Center
Torrance, California, United States
|
|
| 58 |
NCT02801292 |
Unknown † |
Ketamine as an Adjuvant Therapy for Acute Vaso Occlusive Crisis in Pediatric Patients With Sickle Cell Disease |
|
|
Interventional
|
Phase 3 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
20 |
All |
3 Years to 17 Years (Child) |
NCT02801292 |
917282 |
KSickle |
July 2016 |
July 2018 |
July 2018 |
June 15, 2016 |
June 15, 2016 |
|
|
|
| 59 |
NCT02422290 |
Completed |
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD) |
- Obsessive-Compulsive Disorder
|
|
Interventional
|
Phase 1
Phase 2 |
- New York State Psychiatric Institute
- New York Presbyterian Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive Compulsive Scale, Child version (CYBOCS)
- Clinical Global Impressions Scale (CGI-S)
- OCD Visual Analogue Scale (OCD-VAS)
- Yale-Brown Obsessive Compulsive Challenge Scale (YBOCCS)
|
5 |
All |
14 Years to 22 Years (Child, Adult) |
NCT02422290 |
#7023 |
|
March 2015 |
January 1, 2018 |
January 1, 2018 |
April 21, 2015 |
August 20, 2018 |
|
- New York State Psychiatric Institute/Columbia University
New York, New York, United States
|
|
| 60 |
NCT03644719 |
Completed |
Effectiveness of a Brief Cognitive and Behavioral Skills Program on Stage Transitions for Chronic Ketamine Abusers |
|
- Behavioral: Cognitive behavioral skills training
|
Interventional
|
Not Applicable |
- National Taiwan University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Motivation to change
- Knowledge about ketamine
|
409 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03644719 |
Chronic Ketamine Abusers |
|
August 19, 2014 |
March 19, 2017 |
March 19, 2017 |
August 23, 2018 |
August 23, 2018 |
|
|
|
| 61 |
NCT02892916 |
Recruiting |
Ketamine and Postoperative Cognitive Dysfunction |
- Post Operative Cognitive Dysfunction
|
- Drug: Ketamine
- Drug: Placebo
|
Interventional
|
Phase 3 |
- Assistance Publique - Hôpitaux de Paris
- Ministry of Health, France
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Early postoperative delirium
- Postoperative cognitive dysfunction (POCD)
- Depression
- (and 12 more...)
|
900 |
All |
60 Years and older (Adult, Older Adult) |
NCT02892916 |
P150910
2016-000691-16
PHRC-15-15-0534 |
POCK |
March 20, 2017 |
July 2019 |
July 2019 |
September 8, 2016 |
August 13, 2018 |
|
- AP-HP - Hôpital Saint-Antoine
Paris, Île-de-France, France
|
|
| 62 |
NCT03415191 |
Completed |
The Pre-Emptive Administration Of Ketamine for Controlling Post-thoracotomy Pain |
|
- Drug: Ketamine
- Drug: Normal Saline
|
Interventional
|
Not Applicable |
- University of Campania "Luigi Vanvitelli"
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change From Baseline in Pain Scores on the Visual Analog Scale at 48 hours
- Change From Baseline in c-Reactive Protein (CRP) serum levels at 48 hours
- Change From Baseline in morphine consumption at 48 hours
- Indicence of clinical adverse effect in the entire post operative course
|
75 |
All |
18 Years and older (Adult, Older Adult) |
NCT03415191 |
513/12 |
|
January 5, 2012 |
December 21, 2014 |
February 1, 2015 |
January 30, 2018 |
January 30, 2018 |
|
- Alfonso Fiorelli
Naples, Italy
|
|
| 63 |
NCT01892189 |
Completed
Has Results |
Effects of TAK-063 on Preventing Ketamine-Induced Brain Activity Changes as Well as Psychotic-Like Symptoms in Healthy Male Adults |
- Ketamine-Induced Brain Activity Changes
- Psychotic-like Symptoms
|
- Drug: Ketamine
- Drug: TAK-063
- Drug: TAK-063 Placebo
|
Interventional
|
Phase 1 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Ketamine-Induced Brain Activity in Regions of Interest During Resting State
- Cmax: Maximum Observed Plasma Concentration for TAK-063 and TAK-063 Metabolite (M-I)
- Tmax: Time to Reach Cmax for TAK-063 and TAK-063 M-I
- (and 5 more...)
|
27 |
Male |
18 Years to 45 Years (Adult) |
NCT01892189 |
TAK-063_102
U1111-1141-2177 |
|
August 2013 |
August 2014 |
August 2014 |
July 4, 2013 |
January 12, 2017 |
January 12, 2017 |
- The Brain Institute, University of Utah
Salt Lake City, Utah, United States
|
|
| 64 |
NCT02752724 |
Completed |
Ketamine Anesthesia for Improvement of Depression in ECT |
- Major Depressive Disorder
|
- Drug: Ketamine
- Drug: Methohexital
|
Interventional
|
Not Applicable |
- VA Puget Sound Health Care System
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Depression Patient Health Questionnaire 9 (PHQ9) Scoring
- Soluble Amino Acid Metabolomic Biomarkers
- ECT Seizure Duration
- Change in Montreal Cognitive Assessment (MoCA) Scoring
|
52 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT02752724 |
00850 |
KAID |
March 2016 |
April 2017 |
April 30, 2018 |
April 27, 2016 |
June 5, 2018 |
|
- VA Puget Sound Health Care System
Seattle, Washington, United States
|
|
| 65 |
NCT02661061 |
Terminated |
Ketamine for Relapse Prevention in Recurrent Depressive Disorder |
- Depression
- Relapse
- Recurrent Depressive Disorder
- Major Depressive Disorder
|
- Drug: Ketamine
- Drug: Midazolam
|
Interventional
|
Phase 1 |
- St Patrick's Hospital, Ireland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Process outcomes
- Relapse of recurrent depressive disorder: 24-item Hamilton Rating Scale for Depression scores
- Tolerability of infusion regime; performance on assessments for psychomimetic effects, physical health measures, and cognitive assessments
|
9 |
All |
18 Years and older (Adult, Older Adult) |
NCT02661061 |
20/15
2015-002020-37 |
KINDRED |
December 2015 |
May 23, 2018 |
May 23, 2018 |
January 22, 2016 |
August 2, 2018 |
|
- St Patrick's University Hospital
Dublin, Ireland
|
|
| 66 |
NCT03049930 |
Recruiting |
Intraoperative Low-dose Ketamine Infusion as the Main Analgesic in Burn Patients |
|
- Drug: Ketamine
- Drug: Sodium chloride
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Intraoperative fentanyl
- Time to the first narcotic
|
46 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03049930 |
209459 |
|
February 27, 2018 |
August 2020 |
August 2020 |
February 10, 2017 |
March 7, 2018 |
|
- Loyola University Medical Center
Maywood, Illinois, United States
|
|
| 67 |
NCT02860117 |
Recruiting |
Ketamine Continuous Infusion on Opioid Consumption and Pain Management in Severe Burned Patients |
|
- Drug: Ketamine continuous infusion
- Drug: Placebo
|
Interventional
|
Phase 3 |
- University of Sao Paulo General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Opioid consumption
- Side effects questionnaire
|
50 |
All |
18 Years to 60 Years (Adult) |
NCT02860117 |
1551628 |
ccimb |
May 2016 |
January 2019 |
May 2019 |
August 9, 2016 |
July 4, 2018 |
|
- Hospital das Clínicas da FMUSP
Sao Paulo, SP, Brazil
|
|
| 68 |
NCT02659085 |
Active, not recruiting |
Ketamine as an Alternative Treatment to ECT in Major Depressive Disorder |
- Depressive Disorder, Major
|
- Drug: Ketamine IV Infusion
- Procedure: ECT
|
Interventional
|
Phase 2
Phase 3 |
- Pouya Movahed Rad
- Region Skane
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of patients in remission in each treatment arm assessed by Montgomery-Asberg Depression Rating Scale (MADRS)
- Time to remission compared between the two treatments.
- Time to response compared between the two treatments.
- (and 5 more...)
|
200 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT02659085 |
2011-001520-37 |
|
February 2015 |
December 2018 |
December 2018 |
January 20, 2016 |
December 19, 2018 |
|
- Department of Psychiatry
Lund, Sweden
|
|
| 69 |
NCT00797264 |
Completed |
Ketamine Associated With Morphine PCA After Total Hip Arthroplasty |
- Arthroplasty, Replacement, Hip
|
- Drug: Ketamine-Morphine
- Drug: Morphine
- Drug: Postoperative PCA of Ketamine and morphine
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Morphine consumption in PACU and in hospitalisation room
- Postoperative Visual Analogic Score of pain
- Postoperative Measure of mechanical hyperalgesia by Von Frey filament device
- Postoperative measure Ketamine and Nor-Ketamine blood levels
|
18 |
All |
18 Years and older (Adult, Older Adult) |
NCT00797264 |
P060402 |
KETAMINE |
November 2008 |
October 2010 |
October 2010 |
November 25, 2008 |
April 11, 2013 |
|
- Service d'anesthesie-reanimation - Hôpital Bicêtre
Le Kremlin Bicêtre, France
|
|
| 70 |
NCT03448068 |
Recruiting |
Perioperative Ketamine for Pain With Gastric Bypass |
- Laparoscopic Gastric Bypass Surgery
- Ketamine
|
- Drug: Ketamine
- Drug: Standard therapy
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Total Cumulative Perioperative Opioid Dose
- Mean Pain Score
- Number of Subjects Who Needed Anti-emetics During Hospitalization
- (and 5 more...)
|
34 |
All |
18 Years to 69 Years (Adult, Older Adult) |
NCT03448068 |
17-000301 |
|
April 16, 2018 |
February 2021 |
December 2021 |
February 27, 2018 |
April 18, 2018 |
|
- Mayo Clinic in Arizona
Phoenix, Arizona, United States
|
|
| 71 |
NCT02154438 |
Unknown † |
The Effect of Ketamine Infusion on Lumbar Surgery |
|
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pain Scores on the Visual Analog Scale
- Leeds assessment of neuropathic symptoms and signs (LANSS) score
- neuropathic pain scale (NPS) score
- (and 2 more...)
|
56 |
All |
20 Years to 70 Years (Adult, Older Adult) |
NCT02154438 |
3-2014-0062 |
|
May 2014 |
April 2015 |
April 2015 |
June 3, 2014 |
June 3, 2014 |
|
- Gangnam Severance Hospital
Seoul, Korea, Republic of
|
|
| 72 |
NCT02284204 |
Completed |
Sevoflurane Associated With Oral Midazolam and Ketamine for Dental Sedation |
|
- Drug: Midazolam, Ketamine and Sevoflurane
- Drug: Midazolam and Ketamine
|
Interventional
|
Phase 2 |
- Universidade Federal de Goias
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- adverse events
- Behavioral Control
|
27 |
All |
4 Years to 6 Years (Child) |
NCT02284204 |
MKSevadversos |
|
January 2012 |
August 2014 |
November 2014 |
November 5, 2014 |
January 11, 2017 |
|
- Faculty of Dentistry
Goiania, Goias, Brazil
|
|
| 73 |
NCT02962999 |
Completed |
Effect Of Ketamine Infusion In Patients With COPD Applied One Lung Ventilation |
- Chronic Obstructive Pulmonary Disease Mild
- Chronic Obstructive Pulmonary Disease Moderate
- Chronic Obstructive Pulmonary Disease Severe
- (and 2 more...)
|
- Drug: Ketamine
- Drug: Saline
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Prevention
|
- Change of Peak airway pressure (mmHg)
- Change of arteriel P02
- Change of Shunt fraction
- (and 2 more...)
|
30 |
All |
40 Years to 80 Years (Adult, Older Adult) |
NCT02962999 |
KCOPD1 |
|
January 2017 |
March 2018 |
March 2018 |
November 15, 2016 |
May 30, 2018 |
|
- Cukurova University
Adana, Turkey - Cukurova University Faculty of Medicine Research Hospital
Adana, Turkey
|
|
| 74 |
NCT01816958 |
Completed |
Neuromodulation to Facilitate the Effect of Ketamine |
- Depression
- Chronic Pain
- Substance Abuse
|
- Other: co-administration of TMS and infused ketamine
|
Observational
|
|
- The Neuroscience Center, LLC
|
Other |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- Global Assessment of Function in DSM-4R
|
35 |
All |
18 Years and older (Adult, Older Adult) |
NCT01816958 |
12_1293 |
TMS/ketamine |
January 2011 |
November 2012 |
November 2012 |
March 22, 2013 |
March 22, 2013 |
|
- The Neuroscience Center
Deerfield, Illinois, United States
|
|
| 75 |
NCT02341963 |
Recruiting |
A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery |
- Acute Pain Management
- Analgesic, Nonopioid
- Amputation of Lower Extremity, All Causes
|
|
Interventional
|
Phase 1 |
- Rush University Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of Adverse Events
- Acute Postoperative Pain (NRS (numerical rating scale, 0=no pain, 10=worst imaginable pain) score)
- Chronic Postoperative Pain (SF-MPQ scale for phantom limb and stump pain;Defense and Veterans Pain Rating Scale (DVPRS)
- (and 2 more...)
|
10 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02341963 |
ORA#: 14071504 |
|
January 2015 |
December 2018 |
January 2019 |
January 19, 2015 |
May 21, 2018 |
|
- Rush University Medical Center
Chicago, Illinois, United States
|
|
| 76 |
NCT03290495 |
Completed |
Ketamine Effect on Isoflurane Anesthesia |
|
- Drug: ketamine
- Drug: saline
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- recovery time
- gamma wave activity
- processed EEG parameters
|
30 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03290495 |
isoflurane ketamine gamma |
|
September 30, 2017 |
November 15, 2017 |
November 25, 2017 |
September 25, 2017 |
November 28, 2017 |
|
- Minia University Hospital (main hospital)-kornish elnil st.
Al Minyā, Minya, Egypt
|
|
| 77 |
NCT03233035 |
Recruiting |
Ketamine Intra Nasal Traumatology |
|
- Drug: Ketamine
- Drug: Placebos
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Pain resolution
- Intolerance to treatement and adverse events
- Pain resolution time
- (and 2 more...)
|
1000 |
All |
18 Years to 60 Years (Adult) |
NCT03233035 |
Ket-Int-Nas-TR |
Ket |
October 1, 2016 |
January 1, 2018 |
December 1, 2018 |
July 28, 2017 |
July 28, 2017 |
|
- Nouira Samir
Monastir, Emergency Department Monastir, Tunisia 5000, Tunisia - Emergency department of university hospital Fattouma Bourguiba of Monastir
Monastir, Tunisia
|
|
| 78 |
NCT02909465 |
Completed |
Reducing Ketamine-Induced Agitation, by Midazolam or Haloperidol Premedication After Adult Procedural Sedation |
- Ketamine Induced Agitation
|
- Drug: Midazolam
- Drug: Haloperidol
- Drug: placebo
- Drug: Ketamine
|
Interventional
|
Phase 4 |
- Tehran University of Medical Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- agitation
- level of sedation
- clinician's satisfaction
|
185 |
All |
18 Years and older (Adult, Older Adult) |
NCT02909465 |
TehranUMS-ketamine |
|
July 2016 |
April 2017 |
July 2017 |
September 21, 2016 |
November 7, 2017 |
|
- Sina Hospital
Tehran, Iran, Islamic Republic of
|
|
| 79 |
NCT03545503 |
Recruiting |
Evaluating the Hemodynamic Effects of Ketamine Versus Etomidate During Rapid Sequence Intubation |
|
- Drug: Etomidate
- Drug: Ketamine
|
Interventional
|
Phase 4 |
- South East Area Health Education Center, Wilmington, NC
- New Hanover Regional Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Hemodynamic effect as measured by systolic blood pressure before and after RSI
|
400 |
All |
18 Years and older (Adult, Older Adult) |
NCT03545503 |
1712-4 |
Ket-RSI |
January 1, 2018 |
January 2019 |
January 2019 |
June 4, 2018 |
June 4, 2018 |
|
- New Hanover Regional Medical Center
Wilmington, North Carolina, United States
|
|
| 80 |
NCT00961194 |
Completed |
Oral Ketamine Administration in Patients With Peripheral Neuropathic Pain |
|
|
Interventional
|
Phase 2 |
- University Hospital, Toulouse
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Evaluation of pain intensity using a 10 cm visual analogue scale (VAS) (0 = no pain; 10 = worst possible pain) before and after 7 days of oral administration of one of the three doses of ketamine or placebo.
- Pain intensity will be evaluated by measuring thermal sensibility. A thermode will be used to determine the heat and cold pain thresholds (thermotest) and by measuring hyperalgesia
|
22 |
All |
30 Years to 90 Years (Adult, Older Adult) |
NCT00961194 |
0730102
AOL 2007 |
KETACLUD |
March 2009 |
September 2013 |
March 2014 |
August 18, 2009 |
December 2, 2014 |
|
- Service de Neurochirurgie
Toulouse, France
|
|
| 81 |
NCT02611921 |
Completed |
Study of Intranasal Ketamine for Social Impairment in Autism Spectrum Disorder |
|
- Drug: Ketamine
- Drug: Placebo
|
Interventional
|
Phase 1 |
- Children's Hospital Medical Center, Cincinnati
- Roivant Sciences, Inc.
- Cures Within Reach
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Social Withdrawal subscale score of the Aberrant Behavior Checklist (ABC)
- Change in the Clinician-rated CGI Improvement scale (CGI-I)
|
21 |
All |
12 Years to 30 Years (Child, Adult) |
NCT02611921 |
2015-2494 |
|
December 22, 2015 |
May 7, 2018 |
May 7, 2018 |
November 23, 2015 |
October 12, 2018 |
|
- Cincinnati Childrens Hospital Medical Center
Cincinnati, Ohio, United States
|
|
| 82 |
NCT03679390 |
Not yet recruiting |
The Electroencephalogram and Clinical Effect of Ketamine |
- Electroencephalogram
- Consciousness, Loss of
|
|
Interventional
|
Not Applicable |
- National Taiwan University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- Ketamine increase the dissociation energy in EEG
|
300 |
All |
10 Years and older (Child, Adult, Older Adult) |
NCT03679390 |
201605031RINC |
|
November 1, 2018 |
November 1, 2019 |
December 31, 2020 |
September 20, 2018 |
September 20, 2018 |
|
|
|
| 83 |
NCT01135758 |
Terminated |
Study of Depression-Ketamine-Brain Function |
|
|
Interventional
|
Phase 2 |
- Markus KOSEL
- University Hospital, Geneva
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Difference of the MADRS score at baseline and after ketamine injection
|
10 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01135758 |
CE09-144/Psy 09-22 |
|
June 2010 |
June 2015 |
September 2015 |
June 3, 2010 |
December 7, 2015 |
|
- Service de Psychiatrie Adulte, Programme dépression
Geneva, Switzerland
|
|
| 84 |
NCT03305055 |
Terminated |
RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain |
- Acute Pain
- Wound Care
- Posttraumatic Stress Disorder
|
- Drug: ketamine
- Drug: Fentanyl
|
Interventional
|
Phase 4 |
- Johns Hopkins University
- United States Department of Defense
- Congressionally Directed Medical Research Programs
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mean Wound Care Pain
- Trajectory of Mean Wound Care Session Pain (A.; B.)
- Opiate Sparing Effect
- (and 2 more...)
|
4 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03305055 |
IRB00089761
NTI-NTRR15-13 |
|
December 16, 2017 |
March 28, 2018 |
April 21, 2018 |
October 9, 2017 |
December 3, 2018 |
|
- Johns Hopkins Burn Center
Baltimore, Maryland, United States
|
|
| 85 |
NCT03554915 |
Suspended |
Ketamine Versus Midazolam for Prehospital Agitation |
|
- Other: Ketamine-based protocol
- Other: Midazolam-based protocol
|
Observational
|
|
- Minneapolis Medical Research Foundation
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Time from injection of drug to adequate sedation, defined as a score of +1 or less on the AMSS
- Number of participants intubated
- Number of participants experiencing hypersalivation
- (and 4 more...)
|
420 |
All |
18 Years and older (Adult, Older Adult) |
NCT03554915 |
HSR #17-4306 |
|
August 1, 2017 |
August 31, 2018 |
August 31, 2018 |
June 13, 2018 |
July 11, 2018 |
|
- Hennepin County Medical Center
Minneapolis, Minnesota, United States
|
|
| 86 |
NCT01582945 |
Completed
Has Results |
Ketamine Infusion for Treatment-resistant Major Depressive Disorder |
- Major Depressive Disorder
|
|
Interventional
|
Not Applicable |
- Massachusetts General Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Response to Ketamine as Measured by Hamilton Depression Rating Scale -28 Items (HAMD28)
|
14 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01582945 |
2010-P-002800 |
|
April 2012 |
September 2014 |
December 2014 |
April 23, 2012 |
April 20, 2017 |
April 20, 2017 |
- Depression Clinical and Research Program - MGH
Boston, Massachusetts, United States
|
|
| 87 |
NCT02234011 |
Terminated
Has Results |
A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Drug: Ketamine
- Drug: Placebo
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Observing if Ketamine May Cause a Decrease in OCD Symptoms
|
1 |
All |
18 Years to 55 Years (Adult) |
NCT02234011 |
2014P001140 |
|
September 2014 |
January 2016 |
January 2016 |
September 9, 2014 |
May 12, 2017 |
May 12, 2017 |
- McLean Hospital
Belmont, Massachusetts, United States
|
|
| 88 |
NCT03658330 |
Completed |
Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder |
- Major Depressive Disorder
- Alcohol Use Disorder
|
- Drug: Ketamine + Naltrexone
|
Interventional
|
Phase 2 |
- VA Connecticut Healthcare System
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Response in symptoms of depression as measured by the Montgomery-Asberg Depression Rating Scale (MADRS)
- Obsessive Compulsive Drinking Scale (OCDS)
|
5 |
All |
21 Years to 65 Years (Adult, Older Adult) |
NCT03658330 |
GY0004 |
|
May 2016 |
October 2016 |
June 2018 |
September 5, 2018 |
September 7, 2018 |
|
|
|
| 89 |
NCT03469089 |
Active, not recruiting |
Touchscreen-based Cognitive Tests in Healthy Volunteers |
- Cognitive Symptom
- Schizophrenia
|
- Drug: Ketamine 0.58
- Drug: Ketamine 0.31
- Drug: Modafinil
- (and 2 more...)
|
Interventional
|
Phase 1 |
- University of Eastern Finland
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Ketamine-induced cognitive deficits
- Effect of modafinil on ketamine-induced cognitive deficits
|
16 |
Male |
20 Years to 40 Years (Adult) |
NCT03469089 |
REVISE28347
2017-004455-22 |
|
March 12, 2018 |
May 16, 2018 |
December 31, 2019 |
March 19, 2018 |
October 16, 2018 |
|
- University of Eastern Finland, Clinical Research Centre, Brain Research Unit
Kuopio, Finland
|
|
| 90 |
NCT02425202 |
Completed |
Ketamine Infusion for Pediatric Patients With Obstructive Sleep Apnea Syndrome (OSAS) After Tonsillectomy |
- Obstructive Sleep Apnea Syndrome
|
- Drug: Ketamine
- Other: Saline infusion
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Measurement of post-operative opioid requirements after tonsillectomy in obstructive sleep apnea (OSA) patients
- Documentation of respiratory morbidity after tonsillectomy in OSA patients
|
36 |
All |
1 Year to 17 Years (Child) |
NCT02425202 |
B2013:163 |
KOSATA |
December 2014 |
May 3, 2018 |
May 3, 2018 |
April 23, 2015 |
October 15, 2018 |
|
- Health Sciences Center
Winnipeg, Manitoba, Canada
|
|
| 91 |
NCT02233452 |
Completed |
Methadone and Ketamine for Neuropathic Pain Treatment |
|
- Drug: Methadone
- Drug: Ketamine
- Drug: Methadone plus Ketamine
|
Interventional
|
Phase 4 |
- Universidade Federal de Santa Maria
- Santa Casa de Misericórdia de Belo Horizonte
- Hospital de Clinicas de Porto Alegre
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The primary outcome was pain intensity as assessed by visual analogical scale (VAS) scores
- The secondary outcomes were the presence of burning and/or shooting pain, allodynia and side effects.
|
37 |
All |
22 Years to 77 Years (Adult, Older Adult) |
NCT02233452 |
Methadone plus ketamine |
|
January 2012 |
August 2012 |
August 2012 |
September 8, 2014 |
September 8, 2014 |
|
- University Hospital in Santa Maria
Santa Maria, Rio Grande do Sul, Brazil
|
|
| 92 |
NCT02083926 |
Unknown † |
Ketamine Infusion for Social Anxiety Disorder |
|
- Drug: Ketamine
- Drug: Saline
|
Interventional
|
Early Phase 1 |
- Yale University
- Patterson Trust Awards Program in Clinical Research
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Visual Analog Scale (VAS) of Anxiety States
- Anxiety Severity
- Depression Severity
- (and 9 more...)
|
18 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02083926 |
1310012947 |
|
March 2014 |
March 2018 |
March 2018 |
March 11, 2014 |
July 12, 2016 |
|
- Connecticut Mental Health Center
New Haven, Connecticut, United States
|
|
| 93 |
NCT02543385 |
Withdrawn |
S Ketamine Use in Total Abdominal Hysterectomy |
- Total Abdominal Hysterectomy
|
|
Interventional
|
Not Applicable |
- KK Women's and Children's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
|
|
0 |
Female |
21 Years and older (Adult, Older Adult) |
NCT02543385 |
2008/905/D |
SKET |
June 2014 |
June 2015 |
June 2015 |
September 7, 2015 |
September 7, 2015 |
|
|
|
| 94 |
NCT02414932 |
Completed |
Ketamine for Depression Relapse Prevention Following ECT |
|
- Drug: Ketamine
- Drug: Midazolam
|
Interventional
|
Early Phase 1 |
- St Patrick's Hospital, Ireland
- Health Research Board, Ireland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Recruitment rate
- Depression relapse rate
|
6 |
All |
18 Years and older (Adult, Older Adult) |
NCT02414932 |
SPUH 05/14
2014-004262-14 |
KEEP-WELL |
April 2015 |
April 7, 2017 |
April 7, 2017 |
April 13, 2015 |
June 14, 2017 |
|
- St Patrick's University Hospital
Dublin, Ireland
|
|
| 95 |
NCT02697071 |
Completed |
Ketamine for Acute Migraine in the Emergency Department |
|
- Drug: Ketamine
- Drug: Normal Saline
|
Interventional
|
Not Applicable |
- Carilion Clinic
- Virginia Polytechnic Institute and State University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Achievement of pain response after ketamine dose.
- Proportion of patients needing rescue treatment
|
96 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02697071 |
1921 |
|
February 2016 |
March 2017 |
March 2017 |
March 3, 2016 |
June 8, 2017 |
|
- Carilion Roanoke Memorial Emergency Department
Roanoke, Virginia, United States
|
|
| 96 |
NCT01349231 |
Completed
Has Results |
Ketamine Infusion for Obsessive-Compulsive Disorder |
- Obsessive-compulsive Disorder
|
|
Interventional
|
Phase 2 |
- Yale University
- National Alliance for Research on Schizophrenia and Depression
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- OCD Severity
- Depression Symptoms
|
10 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01349231 |
0901004660 |
|
February 2009 |
December 2011 |
December 2011 |
May 6, 2011 |
June 9, 2014 |
June 9, 2014 |
- Connecticut Mental Health Center/ YNHH
New Haven, Connecticut, United States
|
|
| 97 |
NCT02848963 |
Completed |
Comparison of Ketamine-propofol Combinations |
- Agitation
- Postoperative Pain
|
- Drug: Ketamine-propofol mixture
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- PAED(Paediatric Anaesthesia Emergence Delirium) Scores Evaluation
- Anaesthesia depth assessed using the Bispectral Index (BIS)
- Extubation time
- FLACC(Face, leg movement, activity, craying, consolability)
|
75 |
All |
3 Years to 12 Years (Child) |
NCT02848963 |
Ketamine-Propofol |
|
July 2016 |
February 2017 |
February 2017 |
July 29, 2016 |
April 20, 2017 |
|
- Cukurova University
Adana, Sarıçam, Turkey
|
|
| 98 |
NCT02602743 |
Completed |
Propofol-Ketamine vs Remifentanyl-Ketamine for Sedation in Pediatric Patients Undergoing Colonoscopy |
- Delayed Emergence From Anesthesia
|
- Drug: Remifentanyl
- Drug: Propofol
- Drug: Ketamine
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Ketamine, remifentanyl, propofol consumption
- Blood pressure
- Hypoxia
- Heart rate
|
70 |
All |
2 Years to 16 Years (Child) |
NCT02602743 |
PRK01 |
|
August 2016 |
January 2017 |
January 2017 |
November 11, 2015 |
February 6, 2017 |
|
- Cukurova University Faculty of Medicine Research Hospital
Adana, Turkey
|
|
| 99 |
NCT03053830 |
Recruiting |
Open Label Ketamine Treatment for Major Depressive Disorder in Veterans |
- Major Depressive Disorder
|
|
Interventional
|
Phase 2 |
- VA Connecticut Healthcare System
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Montgomery-Asberg Depression Rating Scale (MADRS)
- Change in Quick Inventory of Depressive Symptomatology-Self Report (QUIDS-SR)
- Change in Hamilton Anxiety Rating Scale (HAM-A)
- (and 8 more...)
|
25 |
All |
21 Years to 75 Years (Adult, Older Adult) |
NCT03053830 |
MR0012 |
Ket-MDD |
January 31, 2017 |
January 30, 2020 |
January 30, 2020 |
February 15, 2017 |
June 5, 2018 |
|
- VA Healthcare System
West Haven, Connecticut, United States
|
|
| 100 |
NCT03088384 |
Completed |
Ketamine Infusion Therapy for PTSD in Combat Veterans |
- Stress Disorders, Post-Traumatic
|
|
Observational
|
|
- Klarisana Physician Services PLLC
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Participant score on the PTSD Checklist - 5 (PCL-5) after a series of six ketamine infusions.
- Participant score on the Patient Health Questionnaire - 9 (PHQ-9) after a series of six ketamine infusions.
- Participant score on the Drug Abuse Screening Test (DAST-10) after a series of six ketamine infusions.
- Participant score on the Alcohol Use Disorders Identification Test (AUDIT) after a series of six ketamine infusions.
|
30 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03088384 |
KRP001 |
|
November 28, 2016 |
September 27, 2018 |
September 29, 2018 |
March 23, 2017 |
October 2, 2018 |
|
- Klarisana
San Antonio, Texas, United States
|
|
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