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33 studies found for:    "familial hemophagocytic lymphohistiocytosis"
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Study Details
Participant Details
Rank Status Study
1 Active, not recruiting Administration of Donor T Cells With the Caspase-9 Suicide Gene
Conditions: Acute Lymphoblastic Leukemia;   Myelodysplastic Syndrome;   Acute Myeloid Leukemia;   Chronic Myelogenous Leukemia;   Non Hodgkin Lymphoma;   Hemophagocytic Lymphohistiocytosis;   Familial Hemophagocytic Lymphohistiocytosis;   Hemophagocytic Syndrome;   Epstein Barr Virus Infection;   X-linked Lymphoproliferative Disease
Interventions: Biological: iCaspase9-transduced T cells;   Drug: AP1903
2 Recruiting T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts
Conditions: Acute Lymphoblastic Leukemia;   Non Hodgkins Lymphoma;   Myelodysplastic Syndrome;   Acute Myeloid Leukemia;   Chronic Myelogenous Leukemia;   Hemophagocytic Lymphohistiocytosis (HLH);   Familial Hemophagocytic Lymphohistiocytosis (FLH);   Viral-associated Hemophagocytic Syndrome (VAHS);   X-linked Lymphoproliferative Disease (XLP)
Interventions: Drug: Ara-C;   Drug: Cyclophosphamide;   Biological: Campath-1H;   Radiation: Total Body Irradiation;   Procedure: Stem Cell Infusion
3 Recruiting Tocilizumab and Hemophagocytic Lymphohistiocytosis (HLH)
Condition: Hemophagocytic Lymphohistiocytosis
Intervention: Drug: tocilizumab
4 Completed Hybrid Immunotherapy for Hemophagocytic LymphoHistiocytosis
Condition: Hemophagocytic Lymphohistiocytosis
Interventions: Drug: ATG, rabbit;   Drug: Etoposide;   Drug: Methotrexate;   Drug: hydrocortisone;   Drug: Dexamethasone
5 Recruiting L-DEP Regimen as a Salvage Therapy for Refractory Epstein Barr Virus-induced Hemophagocytic Lymphohistiocytosis
Condition: Hemophagocytic Lymphohistiocytosis
Interventions: Drug: Pegaspargase;   Drug: doxorubicin;   Drug: etoposide;   Drug: methylprednisolone
6 Terminated Pilot Study of Etoposide-based Therapy and Hematopoietic Cell Transplantation for Hemophagocytic Lymphohistiocytosis
Condition: Hemophagocytic Lymphohistiocytosis
Intervention: Drug: IST and/or alloHCT
7 Completed The Prognostic and Diagnostic Value of Ferritin in Critically Ill Patients With Special Focus on Underlying Hemophagocytic Lymphohistiocytosis
Condition: Hemophagocytic Lymphohistiocytosis
8 Active, not recruiting Treatment Protocol for Hemophagocytic Lymphohistiocytosis 2004
Condition: Hemophagocytic Lymphohistiocytosis
Interventions: Drug: Dexamethasone;   Drug: Etoposide;   Drug: Cyclosporin;   Procedure: Intrathecal therapy;   Procedure: Stem cell transplant
9 Unknown  Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders
Conditions: Chediak-Higashi Syndrome;   Graft Versus Host Disease;   X-Linked Lymphoproliferative Syndrome;   Familial Erythrophagocytic Lymphohistiocytosis;   Hemophagocytic Lymphohistiocytosis;   Virus-Associated Hemophagocytic Syndrome
Interventions: Drug: anti-thymocyte globulin;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: etoposide;   Drug: filgrastim;   Drug: methotrexate;   Procedure: allogeneic hematopoietic stem cell transplantation
10 Terminated Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies
Conditions: Immunologic Deficiency Syndromes;   Chediak-Higashi Syndrome;   Common Variable Immunodeficiency;   Graft Versus Host Disease;   X-Linked Lymphoproliferative Syndrome;   Familial Erythrophagocytic Lymphohistiocytosis;   Hemophagocytic Lymphohistiocytosis;   X-linked Agammaglobulinemia;   Wiskott-Aldrich Syndrome;   Chronic Granulomatous Disease;   X-linked Hyper IgM Syndrome;   Severe Combined Immunodeficiency;   Leukocyte Adhesion Deficiency Syndrome;   Virus-Associated Hemophagocytic Syndrome
Interventions: Drug: anti-thymocyte globulin;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: etoposide;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: prednisone;   Procedure: Allogeneic Bone Marrow Transplantation
11 Recruiting L-DEP as an Initial Treatment for EBV-HLH
Condition: Hemophagocytic Lymphohistiocytosis
Interventions: Drug: Pegaspargase;   Drug: doxorubicin hydrochloride liposome injection;   Drug: etoposide;   Drug: methylprednisolone;   Drug: Etoposide;   Drug: dexamethasone
12 Unknown  Trial of DA-EPOCH Regimen for NHL With HLH
Condition: NHL With Hemophagocytic Lymphohistiocytosis
Intervention: Drug: DA-EPOCH
13 Unknown  Combination Chemotherapy Followed By Donor Stem Cell Transplant in Treating Patients With Hemophagocytic Lymphohistiocytosis
Condition: Nonneoplastic Condition
Interventions: Biological: anti-thymocyte globulin;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: dexamethasone;   Drug: etoposide;   Drug: methotrexate;   Drug: mycophenolate mofetil;   Drug: therapeutic hydrocortisone;   Other: laboratory biomarker analysis;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: biopsy
14 Active, not recruiting Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)
Conditions: Hemophagocytic Lymphohistiocytosis;   Chronic Active Epstein-Barr Virus Infection;   Chronic Granulomatous Disease;   HIGM-1;   Leukocyte Adhesion Deficiency;   IPEX
Intervention: Biological: Hematopoietic Stem Cell Transplant
15 Recruiting CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease
Conditions: Bone Marrow Failure Syndrome;   Severe Aplastic Anemia;   Severe Congenital Neutropenia;   Amegakaryocytic Thrombocytopenia;   Diamond-Blackfan Anemia;   Schwachman Diamond Syndrome;   Primary Immunodeficiency Syndromes;   Acquired Immunodeficiency Syndromes;   Histiocytic Syndrome;   Familial Hemophagocytic Lymphocytosis;   Lymphohistiocytosis;   Macrophage Activation Syndrome;   Langerhans Cell Histiocytosis (LCH);   Hemoglobinopathies;   Sickle Cell Disease;   Sickle Cell-beta-thalassemia
Intervention: Biological: CD34 Stem Cell Selection Therapy
16 Recruiting Long-term Follow-up of HLH Patients Who Received Treatment With NI-0501, an Anti-interferon Gamma Monoclonal Antibody
Condition: Hemophagocytic Lymphohistiocytosis
Intervention: Drug: NI-0501
17 Recruiting Treatment of Familiar Lymphohistiocytosis
Condition: Hemophagocytic Lymphohistiocytosis (HLH)
Interventions: Drug: Alemtuzumab;   Drug: Methyl Prednisolone (MP);   Drug: Cyclosporin A (CSA)
18 Completed Secondary Adult's Hemophagocytic Lymphohistiocytosis and Innate Immunity
Condition: Hemophagocytic Lymphohisticytosis
Intervention: Other: blood sample
19 Recruiting Splenectomy as a Treatment for Patient With Relapsed Haemophagocytic Lymphohistiocytosis of Unknown Etiology
Condition: Hemophagocytic Lymphohistiocytosis
Intervention: Procedure: splenectomy
20 Recruiting Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases
Conditions: Primary Immune Deficiency Disorders;   Hemophagocytic Lymphohistiocytosis;   Inherited Bone Marrow Failure Syndrome;   Hemoglobinopathies;   Metabolic Disorders
Intervention: Biological: BPX-501 and AP1903

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