| 1 |
NCT02122328 |
Recruiting |
Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome |
- Twin Twin Transfusion Syndrome
|
- Procedure: Sequential laser photocoagulation of communicating vessels.
- Procedure: Selective laser photocoagulation of communicating vessels
|
Interventional |
Not Applicable |
- University of Southern California
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To compare donor intrauterine survival (alive at birth) for those undergoing SQLPCV vs. SLPCV.
- Surgical complications
|
542 |
Female |
16 Years to 55 Years (Child, Adult) |
NCT02122328 |
HS-09-00680 |
|
June 2010 |
February 2019 |
February 2020 |
April 24, 2014 |
March 13, 2017 |
|
- Huntington Memorial Hospital
Pasadena, California, United States
|
| 2 |
NCT03449823 |
Recruiting |
Renal Artery Dopplers in Twin Twin Transfusion Syndrome |
- Twin Twin Transfusion Syndrome
|
- Diagnostic Test: Doppler ultrasound of fetal renal artery
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Fetal renal artery Doppler PSV for twin A
- Fetal renal artery Doppler RI for twin A
- Fetal renal artery Doppler PI for twin A
- (and 9 more...)
|
24 |
Female |
Child, Adult, Senior |
NCT03449823 |
AAAQ9660 |
|
September 9, 2016 |
June 30, 2018 |
June 30, 2018 |
February 28, 2018 |
February 28, 2018 |
|
- Columbia University Medical Center
New York, New York, United States
|
| 3 |
NCT01622049 |
Completed |
Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome |
- Twin Twin Transfusion Syndrome
|
- Device: Selective Laser Photocoagulation of Communicating Vessels
|
Observational |
|
- University of South Florida
|
Other |
|
- The primary study objective is to evaluate neonatal/infant survival 6 months after birth.
- The secondary study objective is to evaluate the effects of surgery on postnatal neurological morbidity. For the purposes of this clinical trial, neurological morbidity includes any of the following conditions diagnosed within 6 months of birth
|
77 |
Female |
18 Years to 55 Years (Adult) |
NCT01622049 |
#105118 |
TTTS |
October 2006 |
February 2009 |
February 2009 |
June 18, 2012 |
March 14, 2013 |
|
- University of South Florida
Tampa, Florida, United States
|
| 4 |
NCT00345852 |
Unknown † |
Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome |
- Twin to Twin Transfusion Syndrome
|
- Procedure: Fetoscopic Selective Laser Photocoagulation
|
Interventional |
Not Applicable |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Children's Hospital Medical Center, Cincinnati
|
NIH / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Survival of donor twin at 30 days after birth and no treatment failure
- Survival of recipient twin at 30 days after birth and no treatment failure
- Survival times of each twin in utero or after birth (which may be censored at 30 days after birth)
- (and 5 more...)
|
150 |
Female |
18 Years and older (Adult, Senior) |
NCT00345852 |
R01HD041149 |
|
March 2002 |
|
May 2007 |
June 29, 2006 |
June 29, 2007 |
|
- University of California-San Francisco
San Francisco, California, United States - Evanston Northwestern Healthcare
Evanston, Illinois, United States - New York University School of Medicine
New York, New York, United States - (and 9 more...)
|
| 5 |
NCT02506049 |
Enrolling by invitation |
Laser Photocoagulation in Twin to Twin Transfusion Syndrome |
- Twin to Twin Transfusion Syndrome
|
- Device: S-LPC:Selective Laser Photocoagulation
|
Interventional |
Not Applicable |
- University of Tennessee
- Regional Medical Center, Regional One Health
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Laser ablation of placental anastomoses for treatment of severe TTTS and establishment of normalized blood flow between the fetal twins.
|
100 |
Female |
16 Weeks to 27 Weeks (Child) |
NCT02506049 |
10-00755-HUD |
TTTS |
April 2010 |
March 2020 |
March 2022 |
July 22, 2015 |
October 26, 2017 |
|
- Regional One Health, Regional Medical Center, Rout Center for Women and Children
Memphis, Tennessee, United States - University of Tennessee Health Science Center, OB-GYN
Memphis, Tennessee, United States
|
| 6 |
NCT02249624 |
Active, not recruiting |
The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome |
|
|
Observational |
|
- Catherine Cibulskis, MD
- St. Louis University
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Composite outcome of neurodevelopmental impairment - final
- Developmental delay - 4 months
- Developmental delay - 8 months
- (and 2 more...)
|
60 |
All |
up to 3 Years (Child) |
NCT02249624 |
23854 |
|
September 2014 |
September 2020 |
September 2020 |
September 25, 2014 |
January 9, 2018 |
|
- Cardinal Glennon Children's Medical Center
Saint Louis, Missouri, United States
|
| 7 |
NCT02611856 |
Active, not recruiting |
Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin Syndrome |
- Twin to Twin Transfusion Syndrome
|
|
Observational |
|
- Assistance Publique - Hôpitaux de Paris
- Société Française d’Hypentension Artérielle
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Composite measure of the cardiac function
- Composite measure of the renal function
- Composite measure of the glycoregulation
|
179 |
All |
4 Years to 8 Years (Child) |
NCT02611856 |
CRC05069 |
STT |
April 3, 2007 |
June 30, 2022 |
December 31, 2022 |
November 23, 2015 |
December 8, 2017 |
|
- Hôpital Robert Debré
Paris, France
|
| 8 |
NCT03151915 |
Completed |
Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome |
|
|
Observational |
|
- Michael Tchirikov MD, PhD
- Martin-Luther-Universität Halle-Wittenberg
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- postoperative neonatal survival
- Gestational Age at delivery
- Long term neonatal survival
- (and 3 more...)
|
100 |
Female |
17 Years to 45 Years (Child, Adult) |
NCT03151915 |
NeoTTTS-1 |
|
January 1, 2017 |
December 1, 2017 |
December 31, 2017 |
May 12, 2017 |
January 25, 2018 |
|
- Martin-Luther Universität Halle-Wittenberg
Halle, Germany
|
| 9 |
NCT01334489 |
Recruiting |
The Trial of Pessary After Laser for TTTS |
|
- Device: Arabin Cervical Pessary
|
Interventional |
Not Applicable |
- Hospital Universitari Vall d'Hebron Research Institute
- Maternal-Infantil Vall d´Hebron Hospital
- Universitaire Ziekenhuizen Leuven
- Universitätsklinikum Hamburg-Eppendorf
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Delivery before 32 weeks
- Birth weight
- Fetal or neonatal death
- (and 10 more...)
|
352 |
Female |
18 Years and older (Adult, Senior) |
NCT01334489 |
PECEP_LASER Trial |
PECEPLASER |
December 2012 |
December 2017 |
June 2018 |
April 13, 2011 |
March 31, 2017 |
|
- UZ Leuven. Campus Gasthuisberg
Leuven, Belgium - University Medical Center Eppendorf
Hamburg, Germany - Hospital Universitari Vall d'Hebron
Barcelona, Spain
|
| 10 |
NCT03171909 |
Recruiting |
Austrian Registry on the Outcome of Monochorionic Pregnancies |
- Twin Dichorionic Diamniotic Placenta
- Twin Monochorionic Monoamniotic Placenta
- Twin-To-Twin Transfusion Syndrome
- Twin Pregnancy With Antenatal Problem
|
|
Observational |
|
- Medical University of Graz
- Medical University of Vienna
- Medical University Innsbruck
- (and 11 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- occurrence of specific complications
- gestational age at delivery
- birth weight
- (and 6 more...)
|
1000 |
Female |
18 Years to 50 Years (Adult) |
NCT03171909 |
1497/2016 |
MonoReg |
May 1, 2017 |
January 2025 |
January 2025 |
May 31, 2017 |
May 31, 2017 |
|
- Medical University of Graz
Graz, Styria, Austria - Brothers of Saint John of God Eisenstadt
Eisenstadt, Austria - Medical University Innsbruck
Innsbruck, Austria - (and 10 more...)
|
| 11 |
NCT01220011 |
Recruiting |
Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery |
- Blood and Blood Disorders
- Anemia, Neonatal
- Hematologic Disease
- Infant, Newborn, Diseases
|
- Procedure: Fetoscopic laser surgery
|
Interventional |
Phase 4 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- survival and neurological morbidity at the age of 6 months for each foetus randomized
|
142 |
Female |
18 Years and older (Adult, Senior) |
NCT01220011 |
K090601
ID RCB : 2010-A00026-33 |
TTTS1 |
April 2011 |
June 2018 |
July 2018 |
October 13, 2010 |
December 21, 2016 |
|
- Children's Hospital Colorado and Colorado Fetal Care Center
Aurora, Colorado, United States - University of MD /Department of Obstetrics, Gynecology & Reproductive Sciences
Baltimore, Maryland, United States - Fetal Care Center of Cincinnati, Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States - (and 8 more...)
|
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