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57 studies found for:    "Severe Combined Immunodeficiency" OR "adenosine deaminase deficiency"
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Study Details
Participant Details
Identifiers
Dates
Rank Status Study
1 Recruiting Autologous Cryopreserved CD34+ Hematopoietic Cells Transduced With EFS-ADA Lentivirus for ADA SCID
Condition: Severe Combined Immunodeficiency Due to ADA Deficiency
Intervention: Biological: Infusion of autologous cryopreserved EFS-ADA LV CD34+ cells
2 Not yet recruiting Safety and Early Efficacy Study of TBX-1400 in Patients With Severe Combined Immunodeficiencies
Condition: Severe Combined Immunodeficiency
Intervention: Biological: TBX-1400
3 Completed Transplantation of Hematopoietic Cells in Children With Severe Combined Immunodeficiency Syndrome
Condition: Severe Combined Immunodeficiency
Interventions: Procedure: Stem cell transplant;   Drug: Filgrastim, Alemtuzumab;   Device: Miltenyi CliniMACS
4 Completed Gene Therapy ADA Deficiency
Condition: Adenosine Deaminase Deficiency
Intervention: Biological: Intravenous infusion of transduced cells
5 Recruiting Generalized Neonatal Screening of Severe Combined Immunodeficiencies
Condition: Severe Combined Immunodeficiency, Atypical
Intervention: Biological: SCID screening
6 Unknown  Clinical Characteristics and Genetic Profiles of Severe Combined Immunodeficiency in China
Condition: Severe Combined Immunodeficiency
Intervention: Genetic: gene sequencing
7 Completed
Has Results
MND-ADA Transduction of CD34+ Cells From Children With ADA-SCID
Condition: Severe Combined Immunodeficiency
Intervention: Biological: ADA gene transfer
8 Completed Stem Cell Gene Therapy to Treat X-Linked Severe Combined Immunodeficiency (XSCID)
Condition: Severe Combined Immunodeficiency
Intervention: Drug: Gene-Transduced Autologous CD34+ Stem Cells
9 Active, not recruiting Gene Therapy for X-linked Severe Combined Immunodeficiency
Condition: X-linked Severe Combined Immunodeficiency
Intervention: Other: Gene transfer
10 Not yet recruiting Neonatal Screening of Severe Combined Immunodeficiencies
Conditions: Severe Combined Immunodeficiency;   Neonatal Screening
Intervention:
11 Recruiting Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants
Condition: Severe Combined Immunodeficiency Disease, X-linked
Interventions: Genetic: CL20-4i-EF/a-hyc-OPT;   Drug: Busulfan
12 Completed Gene Therapy for ADA-SCID
Condition: Severe Combined Immunodeficiency Syndrome
Intervention: Genetic: gene transduced PBL and/or gene transduced HSC
13 Completed Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector
Conditions: Adenosine Deaminase Deficiency;   ADA-SCID
Intervention: Genetic: Lentiviral Gene Transfer
14 Completed Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study
Condition: Severe Combined Immunodeficiency
Interventions: Drug: ADA PBSC;   Drug: ADA Umbilical Cord Blood Cells;   Drug: Transduced Lymphocytes
15 Active, not recruiting Autologous Transplant of EFS-ADA Modified Bone Marrow Cells for ADA-Deficient Severe Combined Immunodeficiency (SCID)
Condition: ADA-SCID
Intervention: Genetic: EFS-ADA transduced CD34+ cells from the bone marrow
16 Recruiting Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector
Condition: Severe Combined Immunodeficiency
Intervention: Biological: Gene transfer
17 Active, not recruiting Gene Therapy for X-linked Severe Combined Immunodeficiency (SCID-X1)
Condition: X-linked Severe Combined Immunodeficiency
Intervention: Genetic: Single infusion of autologous CD34+ cells transduced with the self-inactivating (SIN) gammaretroviral vector pSRS11.EFS.IL2RG.pre
18 Active, not recruiting Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant
Conditions: Immune System Disorder;   Severe Combined Immunodeficiency
Interventions: Drug: cyclosporine;   Drug: mycophenolate mofetil;   Radiation: total-body irradiation;   Procedure: allogeneic bone marrow transplantation;   Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation;   Other: laboratory biomarker analysis
19 Terminated
Has Results
Hematopoietic Stem Cell Transplantation (HSCT) for Children With SCID Utilizing Alemtuzumab, Plerixafor & Filgrastim
Condition: Severe Combined Immunodeficiency
Interventions: Drug: Transplant Conditioning with Mobilization Only;   Drug: Transplant Conditioning with Mobilization and Alemtuzumab
20 Withdrawn Quality of Life and Neuropsychiatric Sequelae in Patients Treated With Gene Therapy for ADA-SCID and in Their Parents
Condition: ADA-SCID
Intervention:

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Study has passed its completion date and status has not been verified in more than two years.