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"Porphyria" (39 records)
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1 | NCT02180412 | Recruiting | Controlled Trial of Panhematin in Treatment of Acute Attacks of Porphyria |
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Interventional | Phase 2 |
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Other |
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40 | All | 18 Years to 100 Years (Adult, Senior) | NCT02180412 | 10-203 RDCRN-7203 FD-R-03720 |
April 2014 | August 31, 2020 | August 31, 2020 | July 2, 2014 | August 22, 2017 |
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2 | NCT02076763 | Completed | Observational Study of Acute Intermittent Porphyria Patients |
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Observational |
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Industry / Other |
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9 | All | 18 Years to 65 Years (Adult) | NCT02076763 | DIG-API-2011-01 261506 AIPGene |
August 2011 | July 2013 | February 2014 | March 4, 2014 | March 12, 2014 |
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3 | NCT02452372 | Completed | A Phase 1 Study of Givosiran (ALN-AS1) in Patients With Acute Intermittent Porphyria (AIP) |
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Interventional | Phase 1 |
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Industry |
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40 | All | 18 Years to 65 Years (Adult) | NCT02452372 | ALN-AS1-001 | May 2015 | September 2017 | September 2017 | May 22, 2015 | February 12, 2018 |
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4 | NCT02949830 | Active, not recruiting | A Study to Evaluate Long-term Safety and Clinical Activity of Givosiran (ALN-AS1) in Patient With Acute Intermittent Porphyria (AIP) |
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Interventional | Phase 1 Phase 2 |
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Industry |
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17 | All | 18 Years and older (Adult, Senior) | NCT02949830 | ALN-AS1-002 | October 2016 | May 2020 | August 2020 | October 31, 2016 | January 29, 2018 |
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5 | NCT02082860 | Completed | Phase I Gene Therapy Clinical Trial Using the Vector rAAV2/5-PBGD for the Treatment of Acute Intermittent Porphyria |
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Interventional | Phase 1 |
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Industry / Other |
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8 | All | 18 Years to 64 Years (Adult) | NCT02082860 | AAVPBGD-AIP-001 2011-005590-23 |
November 2012 | July 2014 | November 2014 | March 10, 2014 | December 18, 2014 |
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6 | NCT01561157 | Recruiting | Longitudinal Study of the Porphyrias |
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Observational |
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Other |
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800 | All | Child, Adult, Senior | NCT01561157 | GCO 10-1102 | November 2010 | September 2019 | December 2019 | March 22, 2012 | February 15, 2018 |
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7 | NCT01573754 | Recruiting | Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda |
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Interventional | Phase 2 |
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Other |
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100 | All | 18 Years to 100 Years (Adult, Senior) | NCT01573754 | FDA-2604 R01FD002604 |
April 2003 | August 2020 | August 2022 | April 9, 2012 | February 28, 2018 |
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8 | NCT01617642 | Not yet recruiting | Dental Health, Diet, Inflammation and Biomarkers in Patients With Acute Intermittent Porphyria(AIP) |
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Observational |
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Other |
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150 | All | 18 Years and older (Adult, Senior) | NCT01617642 | 2011/2197/REK ID/7462 SFP 1068-12 |
July 2012 | August 2017 | December 2021 | June 12, 2012 | June 12, 2012 |
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9 | NCT00599326 | Completed Has Results |
Pilot Trial of Deferasirox in the Treatment of Porphyria Cutanea Tarda |
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Interventional | Phase 3 |
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Other / Industry |
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10 | All | 18 Years and older (Adult, Senior) | NCT00599326 | CICL670A US17 IRB File Number 062007-047 |
January 2008 | April 2010 | April 2010 | January 23, 2008 | February 10, 2014 | February 10, 2014 |
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10 | NCT02240784 | Recruiting | EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP) |
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Observational |
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Industry |
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300 | All | 18 Years and older (Adult, Senior) | NCT02240784 | ALN-AS1-NT-001 | August 2014 | December 2020 | December 2020 | September 16, 2014 | December 20, 2017 |
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11 | NCT00213772 | Completed | Risk Factors of Porphyria Cutanea Tarda (PCT) |
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Observational |
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Other |
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280 | All | Child, Adult, Senior | NCT00213772 | 2030 | May 1999 | September 21, 2005 | September 21, 2005 | ||||||||
12 | NCT02935400 | Enrolling by invitation | Acute Porphyria Biomarkers for Disease Activity |
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Observational |
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Other |
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50 | All | 18 Years and older (Adult, Senior) | NCT02935400 | 14-0001 | January 2014 | December 2020 | December 2020 | October 17, 2016 | January 25, 2018 |
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13 | NCT02922413 | Recruiting | Panhematin for Prevention of Acute Attacks of Porphyria |
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Interventional | Phase 2 |
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Other |
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20 | All | 18 Years and older (Adult, Senior) | NCT02922413 | 14-0188 | August 2015 | September 2019 | September 2020 | October 4, 2016 | January 25, 2018 |
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14 | NCT01284946 | Unknown † | Safety and Efficacy of Oral Deferasirox in Patients With Porphyria Cutanea Tarda |
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Interventional | Phase 2 |
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Other |
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45 | All | 18 Years and older (Adult, Senior) | NCT01284946 | AEFD2010-01 | January 2011 | December 2012 | December 2012 | January 27, 2011 | January 27, 2011 |
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15 | NCT00004788 | Completed | Study of Nutritional Factors in Porphyria |
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Observational |
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NIH / Other |
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30 | All | Child, Adult, Senior | NCT00004788 | 199/11886 UTMB-328 |
May 1988 | February 25, 2000 | June 24, 2005 | ||||||||
16 | NCT00004331 | Unknown † | Studies in Porphyria I: Characterization of Enzyme Defects |
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Observational |
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NIH / Other |
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25 | All | Child, Adult, Senior | NCT00004331 | 199/11888 UTMB-399 |
November 1992 | October 19, 1999 | June 24, 2005 |
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17 | NCT00004396 | Completed | Studies in Porphyria III: Heme and Tin Mesoporphyrin in Acute Porphyrias |
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Interventional | Phase 2 |
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NIH / Other |
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32 | All | 18 Years and older (Adult, Senior) | NCT00004396 | 199/13185 UTMB-96-476 UTMB-96-318 UTMB-FDR000710 UTMB-FDR001459 |
September 1997 | October 19, 1999 | June 24, 2005 |
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18 | NCT00004330 | Completed | Studies in Porphyria IV: Gonadotropin-Releasing Hormone (GnRH) Analogues for Prevention of Cyclic Attacks |
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Interventional | Not Applicable |
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NIH / Other |
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Female | 18 Years to 55 Years (Adult) | NCT00004330 | 199/11885 UTMB-445 UTMB-312 |
March 1987 | October 19, 1999 | June 24, 2005 |
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19 | NCT00004789 | Completed | Phase I/II Study of Heme Arginate and Tin Mesoporphyrin for Acute Porphyria |
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Interventional | Phase 1 Phase 2 |
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NIH / Other |
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59 | All | 18 Years and older (Adult, Senior) | NCT00004789 | 199/11887 UTMB-398 |
July 1993 | February 25, 2000 | June 24, 2005 | ||||||
20 | NCT00004398 | Completed | Phase I Study of Heme Arginate With or Without Tin Mesoporphyrin in Patients With Acute Attacks of Porphyria |
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Interventional | Phase 1 |
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NIH / Other |
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24 | All | 18 Years and older (Adult, Senior) | NCT00004398 | 199/13191 UTMB-97-118 UTMB-FDR001459 |
January 1998 | May 2000 | October 19, 1999 | June 24, 2005 | |||||
21 | NCT00004397 | Completed | Phase I Study of Tin Mesoporphyrin in Patients on Long Term Heme Therapy for Prevention of Acute Attacks of Porphyria |
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Interventional | Phase 1 |
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NIH / Other |
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20 | All | 18 Years and older (Adult, Senior) | NCT00004397 | 199/13187 UTMB-97-117 UTMB-FDR001459 |
January 1998 | May 2000 | October 19, 1999 | June 24, 2005 | |||||
22 | NCT03118674 | Recruiting | Harvoni Treatment Porphyria Cutanea Tarda |
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Interventional | Phase 2 |
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Other / Industry / NIH |
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49 | All | 18 Years and older (Adult, Senior) | NCT03118674 | IRB00043341 U54DK083909 |
August 10, 2017 | August 30, 2022 | August 30, 2022 | April 18, 2017 | February 20, 2018 |
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23 | NCT01568554 | Recruiting | Clinical Diagnosis of Acute Porphyria |
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Observational |
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Other / NIH |
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600 | All | 15 Years and older (Child, Adult, Senior) | NCT01568554 | PC7204 1U54DK083909 |
December 2011 | December 2018 | December 2018 | April 2, 2012 | September 24, 2013 |
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24 | NCT00005103 | Completed | Study of the Pathogenesis of Porphyria Cutanea Tarda |
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Observational |
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NIH / Other |
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120 | All | Child, Adult, Senior | NCT00005103 | 199/14875 UTMB-433 UTMB-95-173 |
November 2000 | April 7, 2000 | June 24, 2005 |
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25 | NCT00418795 | Completed | Porphozym in the Treatment of Acute Attacks in AIP |
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Interventional | Phase 2 Phase 3 |
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Industry |
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36 | All | 18 Years and older (Adult, Senior) | NCT00418795 | rhPBGD-02 | June 11, 2003 | June 20, 2006 | June 20, 2006 | January 5, 2007 | March 9, 2018 |
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26 | NCT01422915 | Completed Has Results |
Sorbent Therapy of the Cutaneous Porphyrias |
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Interventional | Phase 2 Phase 3 |
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Other |
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4 | All | 22 Years to 60 Years (Adult) | NCT01422915 | 2010P002253 | EPP | May 2011 | March 2012 | March 2012 | August 25, 2011 | April 25, 2017 | April 25, 2017 |
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27 | NCT01880983 | Active, not recruiting | Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC)) |
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Observational |
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Other |
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150 | All | 7 Years and older (Child, Adult, Senior) | NCT01880983 | 7202 | November 2011 | December 2018 | December 2018 | June 19, 2013 | January 17, 2018 |
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28 | NCT03338816 | Recruiting | ENVISION: A Study to Evaluate the Efficacy and Safety of Givosiran (ALN-AS1) in Patients With Acute Hepatic Porphyrias (AHP) |
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Interventional | Phase 3 |
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Industry |
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74 | All | 12 Years and older (Child, Adult, Senior) | NCT03338816 | ALN-AS1-003 | November 1, 2017 | March 2019 | September 2021 | November 9, 2017 | February 28, 2018 |
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29 | NCT00006057 | Completed | Diagnostic and Screening Study of Genetic Disorders |
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Observational |
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NIH / Other |
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50 | All | Child, Adult, Senior | NCT00006057 | 199/15151 MTS-GCO-88-459 |
December 1999 | July 6, 2000 | June 24, 2005 |
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30 | NCT02943213 | Completed Has Results |
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride |
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Interventional | Phase 1 |
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Industry |
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20 | All | 18 Years to 65 Years (Adult) | NCT02943213 | CT-004 PXL231486 |
November 2016 | December 2016 | December 2016 | October 24, 2016 | November 14, 2017 | October 13, 2017 |
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31 | NCT01550705 | Terminated Has Results |
Effect of Isoniazid on Protoporphyrin Levels in Erythropoietic Protoporphyria |
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Interventional | Not Applicable |
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Other / NIH |
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11 | All | 18 Years and older (Adult, Senior) | NCT01550705 | UTINH U54DK083909 |
INHEPP | March 2012 | December 2015 | December 2015 | March 12, 2012 | January 16, 2017 | January 16, 2017 |
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32 | NCT01688895 | Recruiting | Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact |
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Observational |
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Other / NIH |
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150 | All | Child, Adult, Senior | NCT01688895 | GCO 08-0959-04 HSM12-00307 U54DK083909 |
July 2012 | September 2019 | December 2019 | September 20, 2012 | February 15, 2018 |
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33 | NCT00004940 | Completed | Phase III Study of L-Cysteine in Patients With Erythropoietic Protoporphyria |
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Interventional | Phase 3 |
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Other |
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50 | All | 18 Years to 65 Years (Adult) | NCT00004940 | 199/13376 BWH-FDR000996-DR |
May 1996 | September 2001 | February 25, 2000 | March 25, 2015 | |||||
34 | NCT00004831 | Completed | Study of Cysteine Hydrochloride for Erythropoietic Protoporphyria |
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Interventional | Not Applicable |
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U.S. Fed / Other |
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20 | All | 18 Years to 65 Years (Adult) | NCT00004831 | 199/13413 BWH-FDR000996-EF SLRH-CU-FDR000996-EF |
October 1996 | July 1998 | February 25, 2000 | March 25, 2015 | |||||
35 | NCT02979249 | Recruiting | Oral Iron for Erythropoietic Protoporphyrias |
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Interventional | Not Applicable |
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Other / NIH |
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20 | All | 18 Years and older (Adult, Senior) | NCT02979249 | GCO 08-0959-1001 U54DK083909 |
EPP | December 2016 | August 2019 | August 2019 | December 1, 2016 | February 2, 2018 |
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36 | NCT01605136 | Unknown † | Phase III Confirmatory Study in Erythropoietic Protoporphyria |
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Interventional | Phase 3 |
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Industry |
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93 | All | 18 Years and older (Adult, Senior) | NCT01605136 | CUV039 | May 2012 | April 2013 | April 2013 | May 24, 2012 | March 22, 2013 |
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37 | NCT01097044 | Completed | Phase II Confirmatory Study in Erythropoietic Protoporphyria (EPP) |
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Interventional | Phase 2 |
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Industry |
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77 | All | 18 Years and older (Adult, Senior) | NCT01097044 | CUV030 | April 2010 | April 2011 | April 2011 | April 1, 2010 | March 25, 2013 |
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38 | NCT00979745 | Completed | Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP) |
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Interventional | Phase 3 |
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Industry |
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70 | All | 18 Years to 70 Years (Adult, Senior) | NCT00979745 | CUV029 | September 2009 | May 2011 | May 2011 | September 18, 2009 | August 4, 2011 |
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39 | NCT00206869 | Unknown † | Does Exercise and Heat Increase the Lightsensibility in Patients With Erythropoietic Protoporphyria |
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Interventional | Not Applicable |
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Other |
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All | 14 Years to 70 Years (Child, Adult, Senior) | NCT00206869 | KF 01-169/02 | January 2003 | September 21, 2005 | October 11, 2006 |
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† Study has passed its completion date and status has not been verified in more than two years.