| 1 |
NCT01454570 |
Unknown † |
The ReWalk Exoskeletal Walking System for Persons With Paraplegia |
|
|
Observational |
|
- James J. Peters Veterans Affairs Medical Center
|
U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Percent change from baseline
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT01454570 |
JJPVAMC: SPU-09-11
Protocol#: SPU-09-11 |
VA_ReWalk |
February 2011 |
April 2015 |
November 2015 |
October 19, 2011 |
April 10, 2015 |
|
- James J. Peters Veterans Affairs Medical Center; Center of Excellence for the Major Consequences of SCI.
Bronx, New York, United States
|
| 2 |
NCT02042508 |
Unknown † |
Evaluation of a Hybrid Prototype Strategy (Electrostimulation of Lower Limb Muscles Associated With Voluntary Strengthening of the Upper Limbs) in Reconditioning to Effort in Patients With Chronic Paraplegia. |
|
- Other: strengthening
- Other: hybrid training programme
|
Interventional |
Not Applicable |
- Centre Hospitalier Universitaire Dijon
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Maximal oxygen consumption (VO2max) measured during an incremental maximum effort test
|
10 |
All |
18 Years to 45 Years (Adult) |
NCT02042508 |
CASILLAS PARI 2011 |
|
|
February 2016 |
|
January 23, 2014 |
January 23, 2014 |
|
- CHU de Dijon
Dijon, France
|
| 3 |
NCT02604186 |
Completed |
Effects of Botulinum Toxin Injections in Patients With Hereditary Spastic Paraplegia |
- Hereditary Spastic Paraplegia
|
- Other: Botulinum Toxin Injections
- Other: Placebo Injections
|
Interventional |
Phase 2
Phase 3 |
- University of Campinas, Brazil
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Cristália Produtos Químicos Farmacêuticos Ltda.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline in 10 meter maximum gate velocity
- Change from baseline in Spastic Paraplegia Rating Scale (SPRS),
- Change from baseline in Ashworth spasticity scale of adductors and triceps surae muscles
- (and 5 more...)
|
55 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02604186 |
CAAE: 48177315.9.1001.5404 |
SPASTOX |
March 9, 2016 |
March 15, 2017 |
March 15, 2017 |
November 13, 2015 |
November 7, 2017 |
|
- Univeristy of Campinas Hospital
Campinas, SP, Brazil
|
| 4 |
NCT02314208 |
Completed |
Therapeutic Metabolic Intervention in Patients With Spastic Paraplegia SPG5 |
- Spastic Paraplegia, Hereditary
|
- Drug: Xenbilox
- Dietary Supplement: Resveratrol
- Drug: Tahor
|
Interventional |
Phase 2 |
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change of 27-hydroxycholesterol blood level after 2 months of treatment for each treatment
- Modification of the serum acid profile after a 2-month treatment measured in blood and urine samples
- Change of 25-hydroxycholesterol blood level after 2 months of treatment for each treatment
- (and 2 more...)
|
12 |
All |
18 Years and older (Adult, Senior) |
NCT02314208 |
C14-04 |
SPA-M |
January 2015 |
September 27, 2017 |
January 1, 2018 |
December 11, 2014 |
April 3, 2018 |
|
- Pitié-Salpêtrière Hospital
Paris, France
|
| 5 |
NCT00140829 |
Unknown † |
SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias |
- Cerebellar Ataxias
- Spastic Paraplegias
|
|
Observational |
|
- Institut National de la Santé Et de la Recherche Médicale, France
- Institut des Maladies Rares
- National Research Agency, France
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
|
6000 |
All |
2 Years to 70 Years (Child, Adult, Senior) |
NCT00140829 |
RBM01-29
DGS2005/003 |
Spatax |
July 2003 |
|
December 2012 |
September 1, 2005 |
March 27, 2012 |
|
- CHU Mustapha
Algiers, Algeria - Université Libre de Bruxelles - Hôpital Erasme
Brussels, Belgium - The Panum Institute
Copenhagen, Denmark - (and 24 more...)
|
| 6 |
NCT03001531 |
Completed |
Safety and Tolerance of Local Heat Application in the Paralyzed Area of Patients With Complete Paraplegia |
|
- Device: HydroSun
- Device: Hilotherm
|
Interventional |
Not Applicable |
- Swiss Paraplegic Centre Nottwil
- University Hospital, Basel, Switzerland
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- presence of burn injury
- blood perfusion
- skin surface temperature
- skin redness
|
15 |
All |
18 Years to 65 Years (Adult) |
NCT03001531 |
2014-05 |
DecuHeat |
September 2016 |
June 2017 |
August 2017 |
December 23, 2016 |
August 29, 2017 |
|
- Swiss Paraplegic Centre
Nottwil, Switzerland
|
| 7 |
NCT02859428 |
Recruiting |
Disease Natural History and Biomarkers of SPG3A, SPG4A, and SPG31 |
- Hereditary Spastic Paraplegia
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Spastic Paraplegia Rating Scale (SPRS)
- SF-36
|
300 |
All |
7 Years to 80 Years (Child, Adult, Senior) |
NCT02859428 |
160158
16-N-0158 |
|
August 6, 2016 |
August 20, 2020 |
September 30, 2020 |
August 9, 2016 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
| 8 |
NCT00627107 |
Completed |
A Study Testing Safety and Tolerance of the ReWalk Exoskeleton Suit |
|
- Device: ReWalk - a motorized exoskeleton suit
|
Interventional |
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Observation and subject feedback
- subject tolerance
|
6 |
All |
18 Years to 55 Years (Adult) |
NCT00627107 |
RW-002 |
RW |
February 2008 |
January 2009 |
January 2009 |
February 29, 2008 |
November 30, 2010 |
|
- Sheba Medical Center, Neurological Rehabilitation Department
Tel-Hashomer, Israel
|
| 9 |
NCT00429013 |
Terminated |
Pressure Ulcer Formation Prevention in Paraplegics Using Computer and Sensory Substitution Via the Tongue. |
|
- Device: Tongue Display Unit
|
Interventional |
Phase 2 |
- University Hospital, Grenoble
- Centre Medico Universitaire Daniel Douady (CMUDD)
- TIMC-IMAG
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Difference of adapted movement (in term of pressure) between the A and B groups.
- Qualitative and quantitative knowledge evaluation
- Qualitative medical device evaluation
- Adverse event collection
|
12 |
All |
18 Years and older (Adult, Senior) |
NCT00429013 |
DCIC-05-44 |
|
September 2006 |
January 2009 |
March 2009 |
January 30, 2007 |
September 15, 2016 |
|
- University Hospital of Grenoble
Grenoble, Cedex 09, France
|
| 10 |
NCT00023075 |
Completed |
Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis |
- Primary Lateral Sclerosis
- Hereditary Spastic Paraplegia
- Amyotrophic Lateral Sclerosis
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
55 |
All |
Child, Adult, Senior |
NCT00023075 |
010241
01-N-0241 |
|
August 2001 |
|
August 2003 |
August 23, 2001 |
March 4, 2008 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
| 11 |
NCT03405558 |
Recruiting |
Performance Developement of Patients With Paraplegia During First Rehabilitation |
|
|
Observational |
|
- Swiss Paraplegic Centre Nottwil
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
30 |
All |
18 Years to 65 Years (Adult) |
NCT03405558 |
2017-01 |
|
January 1, 2018 |
December 31, 2019 |
December 31, 2019 |
January 23, 2018 |
January 23, 2018 |
|
- Swiss Paraplegic Centre
Nottwil, Lucerne, Switzerland
|
| 12 |
NCT01251549 |
Completed |
Safety and Performance Evaluation of ReWalk Reciprocating Gait Orthosis (RGO) |
- Paraplegia
- Spinal Cord Injuries (SCI)
|
- Device: ReWalk - a motorized exoskeleton suit
|
Interventional |
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
|
32 |
All |
18 Years to 55 Years (Adult) |
NCT01251549 |
RW003 ver. 4 |
|
March 2009 |
March 2013 |
March 2013 |
December 2, 2010 |
October 5, 2016 |
|
- Albert Einstein Medical Center, Moss Rehabilitation Center
Elkins Park, Pennsylvania, United States - Ospedale Valduce di Como, Centro Villa Beretta Italy
Como, Italy
|
| 13 |
NCT00785278 |
Unknown † |
Adjusting Wheelchair Set-Up to Minimize Shoulder Joint Forces During Propulsion |
- Paraplegia
- Upper Limb Pain
|
|
Observational |
|
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Peak shoulder joint forces
- Propulsion Speed
- Horizontal and Vertical Axle Placement
|
9 |
All |
18 Years to 65 Years (Adult) |
NCT00785278 |
R-619-08 |
|
July 2008 |
October 2009 |
July 2010 |
November 5, 2008 |
November 5, 2008 |
|
- Kessler Medical Rehabilitation Research and Education Center
West Orange, New Jersey, United States
|
| 14 |
NCT01537978 |
Completed |
Use of Interactive Gaming for Enhanced Function After Spinal Cord Injury |
- Paraplegia and Tetraplegia
|
- Other: Video gaming for enhanced function after spinal cord injury.
|
Interventional |
Phase 1 |
- VA Palo Alto Health Care System
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Increased Electromyographic actvity of upper the upper arm with video gaming.
- Increased heart rate with Video gaming
|
21 |
All |
18 Years and older (Adult, Senior) |
NCT01537978 |
18834 |
|
February 2012 |
October 2012 |
October 2012 |
February 23, 2012 |
December 10, 2014 |
|
- Va Palo Alto Health Care System
Palo Alto, California, United States
|
| 15 |
NCT03206190 |
Recruiting |
The Pre-SPG4 Study |
- Hereditary Spastic Paraplegia
- Hereditary, Spastic Paraplegia, Autosomal Dominant
|
- Other: SPRS Score and clinical signs
- Behavioral: Cognition Testing using CANTAB
- Diagnostic Test: Lumbar Puncture and blood draw
- (and 4 more...)
|
Interventional |
Not Applicable |
- University Hospital Tuebingen
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Diagnostic
|
- Identification of a change of recognizable signs or symptoms
- Subclinical progression (10m walking time)
- Subclinical progression (5-stair climbing test time)
- (and 13 more...)
|
200 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03206190 |
pre-SPG4 |
|
June 12, 2017 |
May 2027 |
May 2029 |
July 2, 2017 |
July 5, 2017 |
|
- University Hospital Tübingen, Center for Neurology
Tübingen, Germany
|
| 16 |
NCT01739023 |
Completed |
Safety of Autologous Human Schwann Cells (ahSC) in Subjects With Subacute SCI |
- Spinal Cord Injury
- Paraplegia
|
- Biological: Autologous Human Schwann Cells
|
Interventional |
Phase 1 |
- W. Dalton Dietrich
- The Miami Project to Cure Paralysis
- University of Miami
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- International Standards of Neurological Classification for Spinal Cord Injury
- MRI of spinal cord
- Neuropathic pain
- (and 11 more...)
|
9 |
All |
18 Years to 60 Years (Adult) |
NCT01739023 |
20081061 |
|
November 2012 |
August 2016 |
August 2016 |
November 30, 2012 |
September 26, 2017 |
|
- University of Miami Miller School of Medicine
Miami, Florida, United States
|
| 17 |
NCT01203150 |
Completed |
Effects of Exercise in People With Paraplegia |
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Global cardiovascular disease risk score
- Body composition
- Cardiovascular Endurance
- Muscular strength
|
32 |
All |
18 Years to 65 Years (Adult) |
NCT01203150 |
TMP-MN-006 |
|
October 2008 |
September 2012 |
September 2012 |
September 16, 2010 |
March 24, 2015 |
|
- The Miami Project to Cure Paralysis
Miami, Florida, United States
|
| 18 |
NCT03386799 |
Not yet recruiting |
Evaluation of a Power Assistance Device for Wheelchair-DUO |
|
|
Observational |
|
- University Hospital, Lille
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- ESAT questionnaire
- Success rate during the indoor test (wheelchair skill program)
- Time to perform the wheelchair skill program
- (and 3 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03386799 |
2016_75
2017-A02670-53 |
EVALDUO |
February 2018 |
June 2019 |
June 2019 |
December 29, 2017 |
December 29, 2017 |
|
|
| 19 |
NCT03434314 |
Not yet recruiting |
Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging |
- Aortic Aneurysm, Thoracoabdominal
|
- Procedure: Minimally-Invasive Segmental Artery Coil-Embolization
|
Interventional |
Not Applicable |
- University of Leipzig
- European Commission
- German Research Foundation
- (and 7 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary objective is to greatly reduce incidence of ischaemic spinal cord injury and mortality.
- substantial spinal cord injury
- spinal cord injury according to the modified Tarlov scale from TAAA repair to one year
- (and 8 more...)
|
500 |
All |
18 Years and older (Adult, Senior) |
NCT03434314 |
1.0
733203
ET 127/2-1 |
PAPA-ARTiS |
April 2018 |
October 2020 |
September 2021 |
February 15, 2018 |
February 15, 2018 |
|
- Medizinische Universität Innsbruck
Innsbruck, Austria - Herzzentrum Hietzing
Vienna, Austria - University Hospital of Bordeaux
Bordeaux, France - (and 26 more...)
|
| 20 |
NCT00108043 |
Completed |
Orthostatic Tolerance During FES (Functional Electrical Stimulation)-Walking in Paraplegia |
|
- Procedure: FES-evoked functional upright gait
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change of systolic blood pressure during three FES-evoked stepping conditions
- Cardiovascular and Metabolic Responses
- Autonomic Responses
- (and 3 more...)
|
10 |
Male |
18 Years to 55 Years (Adult) |
NCT00108043 |
NHMRC 302013 |
|
March 2004 |
|
December 2006 |
April 13, 2005 |
December 3, 2015 |
|
- Rehabilitation Research Centre, University of Sydney
Sydney, New South Wales, Australia
|
| 21 |
NCT02357914 |
Recruiting |
Freehand Ultrasound to Evaluate Scapular Kinematics in People With Paraplegia |
- Spinal Cord Injuries
- Shoulder Impingement Syndrome
|
|
Observational |
|
- Shirley Ryan AbilityLab
- Northwestern Memorial Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Scapulothoracic joint range of motion, maximum, and minimum position
- Shoulder pathology score
- Wheelchair User's Shoulder Pain Index
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT02357914 |
FUS_81377 |
FUS |
April 2015 |
October 2017 |
November 2017 |
February 6, 2015 |
December 8, 2016 |
|
- Rehabilitation Institute of Chicago
Chicago, Illinois, United States
|
| 22 |
NCT03026816 |
Recruiting |
Epidural Stimulation After Neurologic Damage |
- Spinal Cord Injuries
- Paraplegia, Complete
|
- Device: Epidural Spinal Cord Stimulation
|
Interventional |
Not Applicable |
- University of Minnesota - Clinical and Translational Science Institute
- Minnesota Office of Higher Education
- Minneapolis VA Health Care System
- (and 2 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Volitional Response Index Magnitude
- Change in Blood pressure (Systolic and Diastolic)
- Cerebrovascular Assessment Change
- (and 3 more...)
|
100 |
All |
22 Years and older (Adult, Senior) |
NCT03026816 |
16-4115 |
E-STAND |
August 7, 2017 |
January 2022 |
January 2023 |
January 20, 2017 |
February 19, 2018 |
|
- Hennepin County Medical Center
Minneapolis, Minnesota, United States
|
| 23 |
NCT00838838 |
Completed |
Efficacy of Nebido on Bone Mineral Density (BMD) in Hypogonadal Paraplegic Patients With Confirmed Osteoporosis |
- Hypogonadism
- Paraplegia
- Bone Density
- Osteoporosis
|
- Drug: Testosterone Undeconate (Nebido-R, BAY86-5037)
|
Observational |
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Bone mineral density (CT lumbar spine)
|
26 |
Male |
18 Years and older (Adult, Senior) |
NCT00838838 |
13900
NE0501 |
|
September 2005 |
May 2009 |
May 2009 |
February 6, 2009 |
April 14, 2010 |
|
|
| 24 |
NCT03104088 |
Recruiting |
Studying Cognition in SPG4 |
- Cognitive Impairment
- Hereditary Spastic Paraplegia
|
- Diagnostic Test: CANTAB
- Diagnostic Test: MOCA
|
Observational |
|
- University Hospital Tuebingen
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Identifying cognitive affected domains by using CANTAB
|
50 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03104088 |
Cognition_SPG4 |
|
May 10, 2017 |
March 2018 |
March 2018 |
April 7, 2017 |
May 11, 2017 |
|
- University Hospital Tübingen, Center for Neurology
Tubingen, Germany
|
| 25 |
NCT01208584 |
Completed |
Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions |
- Paraplegia, Spinal
- Myelomeningocele
|
|
Observational |
|
- University Hospital, Basel, Switzerland
- Heidelberg University
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
22 |
All |
18 Years and older (Adult, Senior) |
NCT01208584 |
306/09 |
|
August 2008 |
October 2013 |
October 2013 |
September 24, 2010 |
March 11, 2015 |
|
- University Hospital, Basle (only study site!)
Basle, Switzerland
|
| 26 |
NCT02227407 |
Unknown † |
Reciprocating Gait Orthoses for Paraplegia Patients |
- Myelomeningocele
- Spinal Cord Injury
- Spinal Muscular Atrophy
|
- Device: RGOs(reciprocating gait orthoses)
|
Interventional |
Not Applicable |
- National Taiwan University Hospital
- National Science Council, Taiwan
|
Other |
- Intervention Model: Single Group Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- the difference of joint kinetic data in able-bodied subjects and RGO users
- the difference of gait parameter in able-bodied subjects and RGO users
- the difference of joint kinematic data in able-bodies subjects and RGO users
|
8 |
All |
Child, Adult, Senior |
NCT02227407 |
201305047RINC
200703061R |
UPGO |
August 2013 |
December 2015 |
January 2016 |
August 28, 2014 |
August 28, 2014 |
|
- Rehabilitation Engineering Research Center
Taipei, Taiwan
|
| 27 |
NCT00136630 |
Unknown † |
Natural History, Genetic Bases and Phenotype-genotype Correlations in Autosomal Dominant Spinocerebellar Degenerations |
- Spinocerebellar Ataxias
- Spastic Paraplegias
|
|
Observational |
|
- Institut National de la Santé Et de la Recherche Médicale, France
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
|
225 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00136630 |
RBM01-59 _ AOM03059 |
|
May 2005 |
|
December 2012 |
August 29, 2005 |
January 31, 2012 |
|
- Hôpital Pellegrin
Bordeaux, France - CHU de Grenoble
Grenoble, France - Hôpital Neurologique Pierre Wertheimer
Lyon, France - (and 5 more...)
|
| 28 |
NCT02314221 |
Recruiting |
Exoskeletal-assisted Walking to Improve Mobility, Bowel Function and Cardio-Metabolic Profiles in Persons With SCI |
- Spinal Cord Injury
- Paraplegia
- Tetraplegia
|
- Device: Exoskeletal-assisted walking (ReWalk, Ekso)
|
Interventional |
Not Applicable |
- James J. Peters Veterans Affairs Medical Center
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- 10meter Walk Test
- 6min Walk Test
- Timed-Up-and-Go Test (TUG)
- (and 3 more...)
|
64 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02314221 |
SPU-14-031 |
EAWSCI |
February 2015 |
July 2018 |
January 2019 |
December 11, 2014 |
August 22, 2017 |
|
- Univerity of Maryland rehabilitation and Orthopaedic Institute (UMROI)
Baltimore, Maryland, United States - Kessler Foundation Research Center (KFRC)
West Orange, New Jersey, United States - James J Peteres VA Medical Center
The Bronx, New York, United States
|
| 29 |
NCT01569360 |
Withdrawn |
Study of the Impact of the Use of a Corset on the Respiratory Function of Patients With Spinal Cord Injury |
- Spinal Cord Injury
- Tetraplegia
- Paraplegia
|
|
Interventional |
Phase 3 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Vital capacity in the upright and supine position
- Maximal respiratory pressures
- Blood gases
- (and 4 more...)
|
0 |
All |
18 Years and older (Adult, Senior) |
NCT01569360 |
P091121 |
Garchoise |
March 2012 |
March 2013 |
March 2013 |
April 3, 2012 |
December 19, 2013 |
|
|
| 30 |
NCT01740128 |
Completed
Has Results |
Multimodal Exercises to Improve Leg Function After Spinal Cord Injury |
- Spinal Cord Injuries
- Paraplegia
- Paraparesis
|
- Device: Robotic body weight supported treadmill training
- Other: Harness-supported multimodal balance training
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Motor Evoked Potential (MEP) Amplitude in the Tibialis Anterior Muscle at the End of Training.
- Change From Baseline in ISNCSCI Lower Extremity Motor Score.
- Change From Baseline in Berg Balance Scale Sitting With Back Unsupported Score.
- (and 8 more...)
|
21 |
All |
21 Years to 65 Years (Adult) |
NCT01740128 |
B0881-W
5IK2RX000881-03
01407
SPU-11-077 |
|
January 1, 2013 |
November 30, 2016 |
October 23, 2017 |
December 4, 2012 |
February 26, 2018 |
February 26, 2018 |
- James J. Peters VA Medical Center, Bronx, NY
Bronx, New York, United States
|
| 31 |
NCT02602639 |
Enrolling by invitation |
Functional Electrical Stimulation With Rowing as Exercise After Spinal Cord Injury |
- Spinal Cord Injury
- Paraplegia
- Tetraplegia
|
- Device: Functional electrical stimulation rowing (Odstock 4 channel neuromuscular stimulator with Concept 2 Rower)
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Peak VO2 (volume oxygen) output during exercise
- Body composition
- Leg EMG (electromyogram) while rowing
|
6 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02602639 |
H2014:174 |
FES |
October 2015 |
December 2018 |
September 2019 |
November 11, 2015 |
February 5, 2018 |
|
- University of Manitoba
Winnipeg, Manitoba, Canada
|
| 32 |
NCT01923662 |
Recruiting |
A Neuroprosthesis for Prolonged Standing After SCI Using Multi-Contact Peripheral Nerve Electrodes |
- Spinal Cord Injury
- Paralysis
- Tetraplegia
- Paraplegia
|
- Device: IST-16 (16-Channel implanted stimulator-telemeter
|
Interventional |
Not Applicable |
- VA Office of Research and Development
- National Institutes of Health (NIH)
|
U.S. Fed / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Standing performance in terms of elapsed standing time will be compared across stimulation paradigms for each subject.
- Body weight distribution on the arms and legs will be compared across stimulation paradigms for each subject.
|
10 |
All |
21 Years and older (Adult, Senior) |
NCT01923662 |
B1039-R |
|
April 11, 2013 |
April 10, 2019 |
April 10, 2019 |
August 15, 2013 |
March 30, 2018 |
|
- Louis Stokes VA Medical Center, Cleveland, OH
Cleveland, Ohio, United States
|
| 33 |
NCT01474148 |
Recruiting |
A Neuroprosthesis for Seated Posture and Balance |
- Spinal Cord Injury
- Paralysis
- Tetraplegia
- Paraplegia
|
- Device: IRS-8 (8-Channel implanted stimulator-telemeter)
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effect of Trunk stimulation on control seated posture, respiration, seated interface pressures, reach ability, seated stability & personal mobility.
- Design a simple position controller
|
10 |
All |
21 Years and older (Adult, Senior) |
NCT01474148 |
A1204-R
IRB#07101-H36 |
Trunk Protocol |
July 1, 2011 |
January 31, 2019 |
January 31, 2019 |
November 18, 2011 |
March 29, 2018 |
|
- Louis Stokes VA Medical Center, Cleveland, OH
Cleveland, Ohio, United States
|
| 34 |
NCT02354625 |
Recruiting |
The Safety of ahSC in Chronic SCI With Rehabilitation |
- Spinal Cord Injury
- Paraplegia
- Quadriplegia
- Tetraplegia
|
- Biological: Autologous human Schwann cells
|
Interventional |
Phase 1 |
- W. Dalton Dietrich
- The Miami Project to Cure Paralysis
- University of Miami
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- International Standards of Neurological Classification of Spinal Cord Injury
- Magnetic Resonance Imaging of spinal cord
- Neuropathic Pain Symptoms Inventory
- (and 25 more...)
|
10 |
All |
18 Years to 65 Years (Adult) |
NCT02354625 |
20140846 |
|
January 2015 |
January 2019 |
January 2019 |
February 3, 2015 |
February 20, 2018 |
|
- University of Miami
Miami, Florida, United States
|
| 35 |
NCT01498991 |
Completed |
Spinal Cord Injury Leg Rehabilitation |
- Spinal Cord Injury
- Paraplegia
- Quadriplegia
- Tetraplegia
|
|
Interventional |
Phase 1
Phase 2 |
- Oregon Health and Science University
- Shepherd Center, Atlanta GA
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Gait Velocity
- Vibration Threshold Test
- Modified Ashworth Scale
- (and 5 more...)
|
17 |
All |
18 Years to 65 Years (Adult) |
NCT01498991 |
IRB00007762
R01NS061304-22 |
AMES |
November 2011 |
November 2016 |
November 2016 |
December 26, 2011 |
November 28, 2016 |
|
- Shepherd Center, Crawford Research Center
Atlanta, Georgia, United States - Oregon Health and Science University
Portland, Oregon, United States
|
| 36 |
NCT02600910 |
Recruiting |
Natural History of Shoulder Pathology in Manual Wheelchair Users |
- Paraplegia
- Spinal Cord Injuries
- Shoulder Pain
- Tendinopathy
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Participant completion of MRI and Field measurements after 3 to 5 years follow-up.
- Development of the Conceptual Model of Preclinical Natural History of Shoulder Health Decline.
|
75 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02600910 |
15-004974 |
NHSSI |
November 2015 |
December 2019 |
December 2020 |
November 9, 2015 |
February 23, 2017 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
| 37 |
NCT02188277 |
Completed |
Treatment With Xeomin Versus Botox in Children With Spastic Equine and Equinovarus Foot Deformation in Pediatric Cerebral Palsy |
- Cerebral Palsy
- Spastic Paraplegia and Hemiparesis
- Equine and Equinovarus Foot Deformation
|
|
Interventional |
Phase 2 |
- Merz Pharmaceuticals GmbH
- LLC Merz Pharma, Russia
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes from baseline in the degree of spasticity in gastrocnemius according to modified Ashworth scale (AS)
- Changes from baseline in patient percentage in groups by the degree of gastrocnemius spasticity according to modified Ashworth scale
- Percentage of decrease in M-response magnitude and area recorded from the lateral and medial gastrocnemius heads, from baseline values
- (and 4 more...)
|
64 |
All |
2 Years to 12 Years (Child) |
NCT02188277 |
MRZ-R-201212_01001_N_2 |
XEBEC |
July 2014 |
December 2016 |
December 2016 |
July 11, 2014 |
January 26, 2017 |
|
- State Budget Institution of Health in Moscow "Scientific and Practical Center of Pediatric psychoneurology Moscow Health Department"
Moscow, Russian Federation - Federal State Autonomous Institution "Scientific Center of Children's Health" of the Ministry of Health of the Russian Federation
Moscow, Russian Federation - Federal State Budget Educational Institution of Higher Professional Learning "Stavropol State Medical University" of the Ministry of Health of the Russian Federation
Stavropol, Russian Federation
|
| 38 |
NCT03114345 |
Not yet recruiting |
Correlation Between Pressure Differences and Micro-vascularization Changes in Bedridden Paraplegic Patient |
- Pressure Ulcer
- Bedsore
- Spinal Cord Injury
- Paraplegia
|
- Other: Measurement of interface pressure
- Other: Measurement of micro-vascularization related parameters
|
Interventional |
Not Applicable |
- University Hospital, Montpellier
- Hill-Rom
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Measure of the pressure intensity in one area
- Measure of the hemoglobin quantity in the same area
- Measure of other micro-vascularization related parameters (such as the oxygen saturation and the blood flow) recorded at the same area.
|
50 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT03114345 |
9830 |
VASCIP |
October 2017 |
October 2019 |
October 2019 |
April 14, 2017 |
October 17, 2017 |
|
- University Regional Hospital Lapeyronie
Montpellier, Languedoc-Roussillon, France
|
| 39 |
NCT02412046 |
Recruiting |
Quantification of the Pressure Threshold Related to Tissue Injury in Bedriden Paraplegics |
- Pressure Ulcer
- Bedsore
- Spinal Cord Injury
- Paraplegia
|
|
Interventional |
Not Applicable |
- University Hospital, Montpellier
- Hill-Rom
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- The interface pressure will be continuously assessed using a mapping device (XSensor) during 3 hours.
- The microvascularization changes underneath the compressed skin and the inflammatory response of the muscle cells.
|
48 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02412046 |
95022 |
|
October 2015 |
October 2018 |
October 2018 |
April 8, 2015 |
August 4, 2016 |
|
- CHU Montpellier
Montpellier, France
|
| 40 |
NCT00385918 |
Completed
Has Results |
Robotically Assisted Treadmill Training in Spinal Cord Injury (SCI) |
- Paraplegia
- Quadriplegia
- Spinal Cord Injury
- Tetraplegia
|
- Device: Lokomat Training
- Other: Home stretching then Lokomat training
|
Interventional |
Not Applicable |
- VA Office of Research and Development
- University of Maryland
- Kernan Orthopaedics and Rehabilitation Hospital
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Cardiovascular Fitness as Determined by Lokomat Peak VO2 Assessments
- Cardiovascular Fitness as Determined by Arm Cycle Ergometry VO2 Peak Assessments.
- Body Mass
- (and 6 more...)
|
18 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00385918 |
B4027
B40271
HP-00042597 |
|
October 2006 |
June 2011 |
June 2011 |
October 11, 2006 |
May 14, 2014 |
May 14, 2014 |
- VA Maryland Health Care System, Baltimore
Baltimore, Maryland, United States - University of Maryland Rehabilitation and Orthopaedic Institute
Baltimore, Maryland, United States
|
| 41 |
NCT00221767 |
Completed |
Medico-economical Impact of the Brindley Neurosurgical Technique in France |
- Spinal Cord Injuries
- Neurogenic Bladder Disorder
- Paraplegia
- Quadriplegia
|
- Device: Brindley technique (bladder system)
|
Interventional |
Not Applicable |
- University Hospital, Bordeaux
- Ministry of Health, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Proportion of patients showing a complete voluntary (including electrostimulation) micturition
- Bladder capacity (cystometry)
- costs
- (and 6 more...)
|
53 |
All |
18 Years and older (Adult, Senior) |
NCT00221767 |
9415-04
2004-001 |
BRINDLEY |
June 2005 |
March 2010 |
March 2010 |
September 22, 2005 |
June 14, 2012 |
|
- Neurochirurgie A - Hôpital Pellegrin , Place Amélie Raba-Léon
Bordeaux Cedex, France
|
| 42 |
NCT02852278 |
Enrolling by invitation |
A Patient Centric Motor Neuron Disease Activities of Daily Living Scale |
- Amyotrophic Lateral Sclerosis
- Progressive Muscular Atrophy
- Primary Lateral Sclerosis
- Hereditary Spastic Paraplegia
|
|
Observational |
|
- University of South Florida
- National Institutes of Health (NIH)
- University of Kansas
- University of Miami
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
356 |
All |
18 Years and older (Adult, Senior) |
NCT02852278 |
CReATe 8003
U01TR001263 |
|
December 2016 |
June 12, 2019 |
June 12, 2019 |
August 2, 2016 |
March 2, 2018 |
|
|
| 43 |
NCT00623389 |
Recruiting |
Evaluation of an Advanced Lower Extremity Neuroprostheses |
- Spinal Cord Injuries
- Stroke
- Paralysis
- (and 2 more...)
|
- Device: IST-16 (16-channel implanted stimulator-telemeter)
|
Interventional |
Not Applicable |
- Case Western Reserve University
- National Institutes of Health (NIH)
- VA Office of Research and Development
|
Other / NIH / U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Standing, walking and balance performance
- Standing duration, reachable workspace, and ability to perform other functional activities of daily living
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT00623389 |
EB-001889
NS-040547 |
LE-IST |
May 2005 |
January 2019 |
June 2019 |
February 26, 2008 |
January 25, 2018 |
|
- Louis Stokes Cleveland VA Medical Center
Cleveland, Ohio, United States - MetroHealth System
Cleveland, Ohio, United States
|
| 44 |
NCT01909154 |
Completed |
Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia |
|
- Biological: Mesenchymal stromal cell therapy
|
Interventional |
Phase 1 |
- Puerta de Hierro University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
12 |
All |
18 Years to 60 Years (Adult) |
NCT01909154 |
CME-LEM1
2010-023285-46 |
CME-LEM1 |
March 2013 |
April 2014 |
March 2015 |
July 26, 2013 |
June 18, 2015 |
|
- Hospital Puerta de Hierro
Majadahonda, Madrid, Spain
|
| 45 |
NCT01568658 |
Recruiting |
Genetic and Physical Study of Childhood Nerve and Muscle Disorders |
- Muscular Dystrophies
- Muscle Myopathies
- Hereditary Spastic Paraplegias
- (and 2 more...)
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
|
5650 |
All |
Child, Adult, Senior |
NCT01568658 |
120095
12-N-0095 |
|
March 14, 2012 |
|
|
April 2, 2012 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 46 |
NCT03399968 |
Recruiting |
Extracorporeal Shockwave Therapy (ESWT) to Improve Function in Chronic ASIA-A Patients |
|
- Device: ESWT
- Device: Placebo ESWT
|
Interventional |
Not Applicable |
- AUVA Trauma Center Meidling
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Motor function
- Sensitivity and Motor function
- Spasticity
- (and 3 more...)
|
25 |
All |
18 Years and older (Adult, Senior) |
NCT03399968 |
ESWT_SCI/1.9-2014 |
|
March 26, 2015 |
December 31, 2018 |
May 31, 2019 |
January 17, 2018 |
January 23, 2018 |
|
- AUVA Rehabilitation Center Weisser Hof
Klosterneuburg, Lower Austria, Austria - AUVA Rehabilitation Center Tobelbad
Haselsdorf, Styria, Austria
|
| 47 |
NCT03204773 |
Not yet recruiting |
Studying Non-motor Symptoms in SPG4 |
|
- Diagnostic Test: EuroQol five dimensions questionaire (EQ-5D)
- Diagnostic Test: Modified Fatigue Impact Scale (MFI)
- Diagnostic Test: Brief Pain Inventory (BPI)
- (and 2 more...)
|
Observational |
|
- University Hospital Tuebingen
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Identification of relevant non-motor symptoms in SPG4
|
600 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03204773 |
NMS in SPG4 |
|
December 2017 |
July 2019 |
August 2019 |
July 2, 2017 |
October 27, 2017 |
|
- University Hospital Tübingen, Center for Neurology
Tübingen, Germany
|
| 48 |
NCT02700178 |
Recruiting |
Biofeedback for Wheelchair Users |
|
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- change in risk of shoulder impingement
- change in wrist posture
|
15 |
All |
18 Years to 60 Years (Adult) |
NCT02700178 |
15-008240 |
|
April 2016 |
September 2018 |
September 2018 |
March 7, 2016 |
January 23, 2018 |
|
- Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
| 49 |
NCT03495986 |
Not yet recruiting
New |
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement |
- Spinal Cord Injuries
- Metabolic Syndrome
- Dietary Modification
- (and 2 more...)
|
- Device: Functional Electrical Stimulation Leg Cycle Ergometry
- Behavioral: Diet
|
Interventional |
Not Applicable |
- Milton S. Hershey Medical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percent Body fat
- Fat Mass and Fat-Free Mass
- Insulin Sensitivity (Si)
- (and 5 more...)
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT03495986 |
6996
R01HD091278-01 |
SCIENCE |
April 2018 |
April 2022 |
July 2022 |
April 12, 2018 |
April 12, 2018 |
|
- Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
|
| 50 |
NCT00957762 |
Unknown † |
Body Composition Assessment in Spinal Cord Injury |
- Diabetes Mellitus
- Body Composition
- Tetraplegia
- (and 2 more...)
|
|
Observational |
|
- Hunter Holmes Mcguire Veteran Affairs Medical Center
|
U.S. Fed |
- Time Perspective: Prospective
|
- To compare different methods of body composition analyses with the gold standard 4-compartment monitoring to determine accuracy and validity of those alternative, but less labor-intensive techniques.
- To assess the relationship between % body fat, visceral fat, and markers of the metabolic syndrome, including Plasminogen Activator Inhibitor-1 (PAI-1), Thrombin-Activatable Fibrinolysis Inhibitor (TAFI), and high-sensitivity C-Reactive Protein (hsCRP)
- To develop body composition regression equations that can be easily utilized in a clinical setting to estimate risk for the metabolic syndrome in persons with SCI.
- To cross-validate the derived regression equations against the gold standard 4-compartment model in an independent group of persons with SCI.
|
170 |
All |
18 Years to 65 Years (Adult) |
NCT00957762 |
B6232I
HM12090 |
|
August 2009 |
September 2012 |
October 2012 |
August 12, 2009 |
August 12, 2009 |
|
- Hunter Holmes McGuire Spinal Cord Injury Research Lab
Richmond, Virginia, United States
|
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