| 1 |
NCT03502148 |
Not yet recruiting
New |
Study of Safety, Tolerability and Anti-Tumor Effects of PRV111 in Subjects With Oral Squamous Cell Carcinoma |
- Oral Squamous Cell Carcinoma
|
- Drug: PRV111 (Cisplatin Transmucosal System)
|
Interventional |
Phase 1
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Determination of a safe and efficacious dose of PRV111
- Evaluate tumor volume shrinkage
- Evaluate histological response
- Evaluate systemic, tumor and lymph node (if available) platinum levels following PRV111 administration
|
31 |
All |
18 Years and older (Adult, Senior) |
NCT03502148 |
CLN-001 |
PRV111 |
April 30, 2018 |
October 30, 2019 |
December 31, 2019 |
April 18, 2018 |
April 18, 2018 |
|
- Baylor College of Medicine
Houston, Texas, United States
|
| 2 |
NCT01334320 |
Recruiting |
Survival Benefit of Elective Neck Dissection in T1,2N0M0 Oral Squamous Cell Carcinoma |
- Oral Squamous Cell Carcinoma
|
- Procedure: elective neck dissection
|
Interventional |
Not Applicable |
- Sun Yat-sen University
- First Affiliated Hospital, Sun Yat-Sen University
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Whether elective neck dissection (END) has equal or higher survival rate to the wait and watch policy
- Does END have the equal or lower recurrence rate to the wait and watch policy
- quality of life
|
448 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT01334320 |
2010018 |
|
April 2011 |
December 2015 |
December 2021 |
April 13, 2011 |
April 10, 2015 |
|
- Hospital of Stomatology, Sun Yat-sen University
Guangzhou, Guangdong, China - Cancer Center, Sun Yat-Sen University Cancer Center
Guangzhou, Guangdong, China - The First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China - Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, China
|
| 3 |
NCT01987934 |
Unknown † |
Comparison of Morphometric Assessment Using Methyl Green Pyronin and AgNOR Staining of Oral Squamous Cell Carcinoma |
- Oral Squamous Cell Carcinoma
- Oral Epithelial Dysplasia
|
|
Observational |
|
- Academy of Interdisciplinary Dental Education and Research
- Post Graduate Medical Institute, Lahore, Pakistan
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Mean values of diameter, area and number of nuclei and nucleoli.
- Association of grading of OSCC in relation to morphometric parameters
|
60 |
All |
Child, Adult, Senior |
NCT01987934 |
AIDER-1301-AR |
OSCC |
June 2013 |
November 2013 |
December 2013 |
November 20, 2013 |
November 20, 2013 |
|
- Post Graduate Medical Institute
Lahore, Punjab, Pakistan
|
| 4 |
NCT02739204 |
Unknown † |
Concurrent Radiotherapy and/or Cisplatin With or Without Celecoxib in Patients With Primary Oral Squamous Cell Carcinoma |
- Oral Squamous Cell Carcinoma
|
|
Interventional |
Phase 2 |
- China Medical University Hospital
- Ministry of Health and Welfare, Taiwan
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Relapse-free recurrence
- Relapse-free survival
|
270 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT02739204 |
CMUH102-REC1-071 |
|
November 2013 |
December 2016 |
December 2017 |
April 15, 2016 |
April 15, 2016 |
|
- Department of Otolaryngology
Taichung, Taiwan
|
| 5 |
NCT01587573 |
Recruiting |
Developing an In-vitro Diagnostic Risk-Stratification Test for Oral Cancer |
- Oral Squamous Cell Carcinoma
|
- Other: saliva collection prior to clinically driven oral biopsy
|
Observational |
|
|
Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Test specificity at 90% sensitivity
- Validation of individual mRNA and protein markers
- Validation of a pre-specified multi marker model
|
370 |
All |
18 Years and older (Adult, Senior) |
NCT01587573 |
PeriRx-1 |
|
April 2012 |
September 2018 |
December 2018 |
April 30, 2012 |
April 12, 2018 |
|
- University of Illinois at Chicago
Chicago, Illinois, United States - University of Michigan
Ann Arbor, Michigan, United States - Department of Surgery, Michigan Sate University
East Lansing, Michigan, United States - (and 2 more...)
|
| 6 |
NCT03085147 |
Recruiting |
A Dye for the Detection of Cancer of the Tongue and Mouth |
- Oral Squamous Cell Carcinoma (OSCC)
|
|
Interventional |
Phase 1
Phase 2 |
- Memorial Sloan Kettering Cancer Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- escalating levels of toxicity (CTCAE v 4.0)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03085147 |
15-336 |
|
March 15, 2017 |
March 2019 |
March 2019 |
March 21, 2017 |
March 23, 2018 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 7 |
NCT03345966 |
Not yet recruiting |
Assessment of Bmi-1 on Protein and Molecular Levels in Oral Dysplasia and Squamous Cell Carcinoma: A Diagnostic Study |
- Oral Squamous Cell Carcinoma
|
- Diagnostic Test: Bmi-1 antibody
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- oral squamous cell carcinoma
|
18 |
All |
Child, Adult, Senior |
NCT03345966 |
CEBD-CU-2017-11-01 |
|
December 1, 2017 |
December 2018 |
November 2019 |
November 17, 2017 |
November 17, 2017 |
|
- Asmaa M. Abou Gabal
Cairo, Egypt
|
| 8 |
NCT03109457 |
Not yet recruiting |
Hepatitis C Virus Detection in Oral Squamous Cell Carcinoma |
|
- Other: oral squamous cell carcinoma
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Hep C cAg by Immunohistochemistry
|
40 |
All |
Child, Adult, Senior |
NCT03109457 |
CEBD-CU-2017-04-01 |
|
September 2017 |
February 2018 |
April 2018 |
April 12, 2017 |
April 13, 2017 |
|
|
| 9 |
NCT02852343 |
Active, not recruiting |
One-step Nucleic Acid Amplification for Detecting Lymph Node Metastasis of Head and Neck Squamous Cell Carcinoma |
- cN0 Oral Squamous Cell Carcinomas
|
|
Observational |
|
- Rennes University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- number of CK19 mRNA copies/µL of diluted lymph node lysate
|
26 |
All |
18 Years and older (Adult, Senior) |
NCT02852343 |
35RC14_9878 |
OSNA-ORL |
December 2014 |
December 2016 |
December 2017 |
August 2, 2016 |
April 25, 2017 |
|
- Centre hospitalier universitaire de Rennes
Rennes, France
|
| 10 |
NCT02009852 |
Unknown † |
The Role of microRNA-29b in the Oral Squamous Cell Carcinoma |
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case-Only
|
|
100 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT02009852 |
201309076RIN |
microRNA-29b |
January 2014 |
December 2014 |
|
December 12, 2013 |
December 12, 2013 |
|
- National Taiwan University Hospital research Ethics Committee
Taipei, Taiwan
|
| 11 |
NCT02306967 |
Active, not recruiting |
Fluorescent Visualization in Early Oral Cancer |
- Oral Squamous Cell Carcinoma or Severe Dysplasia
|
- Procedure: resection of oral cancer
|
Interventional |
Not Applicable |
- University of Calgary
- Terry Fox Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- disease specific survival
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02306967 |
UCENT004 |
|
September 2011 |
October 2017 |
December 2017 |
December 3, 2014 |
October 26, 2017 |
|
- Foothills Hospital
Calgary, Alberta, Canada
|
| 12 |
NCT01542931 |
Completed |
TPF Induction Chemotherapy for Locally Advanced and Resectable Oral Squamous Cell Carcinoma |
- Stage III Oral Cavity Squamous Cell Carcinoma
- Stage IVA Oral Cavity Squamous Cell Carcinoma
|
- Drug: TPF induction chemotherapy
|
Interventional |
Phase 2
Phase 3 |
- Shanghai Jiao Tong University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Survival rate
- local control
- Number of participants with adverse events
|
256 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT01542931 |
TPF for resectable OSCC
2007BAI18B03 |
|
January 2008 |
December 2015 |
December 31, 2015 |
March 2, 2012 |
August 21, 2017 |
|
- Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai, China
|
| 13 |
NCT00933387 |
Completed |
A Study of Neoadjuvant Bio-C/T Followed by Concurrent Bio-R/T in High-risk Locally Advanced Oral Squamous Cell Carcinoma |
|
- Drug: Cetuximab,Paclitaxel,Cisplatin
|
Interventional |
Phase 2 |
- National Health Research Institutes, Taiwan
- China Medical University Hospital
- National Cheng-Kung University Hospital
- (and 3 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary endpoint is the overall response rate after completion of the assigned treatment.
- Secondary endpoints include the response rate after neoadjuvant therapy, progression-free survival, overall survival, biomarker prediction, and toxicity.
|
47 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT00933387 |
T1309
EMR62202-845 |
|
September 2009 |
July 2011 |
November 2013 |
July 7, 2009 |
May 4, 2016 |
|
- National Health Research of Institutes, Taiwan Cooperative Oncology Group
Tainan, Taiwan
|
| 14 |
NCT03292822 |
Not yet recruiting |
Effects of (Licochalcone A) and Paclitaxel on Human Oral Squamous Cell Carcinoma Cell Line |
|
- Dietary Supplement: Licochalcone A
- Drug: Paclitaxel
|
Interventional |
Early Phase 1 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
|
18 |
All |
Child, Adult, Senior |
NCT03292822 |
CEBD-CU-2017-09-26 |
|
November 1, 2017 |
September 1, 2018 |
April 1, 2019 |
September 26, 2017 |
September 26, 2017 |
|
- Cairo University
Cairo, Egypt
|
| 15 |
NCT02743832 |
Recruiting |
A Study on Tumor Budding Guiding Individualized Surgical Planning of Early-stage Oral Squamous Cell Carcinoma. |
|
- Procedure: Resection for primary lesion and cervical lymph node dissection
- Procedure: Resection for primary lesion
|
Interventional |
Not Applicable |
- Jinsong Hou
- First Affiliated Hospital, Sun Yat-Sen University
- Second Affiliated Hospital, Sun Yat-Sen University
- Sun Yat-sen University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Five-year survival rate
- Recurrence rate
- Quality Of Life
- Disease-free survival
|
524 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT02743832 |
HouJ-2015018 |
|
July 2015 |
June 2020 |
June 2025 |
April 19, 2016 |
April 21, 2016 |
|
- Guanghua School of Stomatolagy, Hospital of Stomatolagy Sun Yat-sen University
Guangzhou, Guangdong, China
|
| 16 |
NCT02290145 |
Recruiting |
Cyclin D1 Based TPF Induction Chemotherapy for Oral Squamous Cell Carcinoma Patients at Clinical N2 Stage |
- Mouth Neoplasms
- Carcinoma, Squamous Cell
|
- Drug: TPF group
- Procedure: surgery group
- Radiation: Post-operative radiotherapy
|
Interventional |
Phase 2 |
- Shanghai Jiao Tong University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- overall survival rate as a measure by the numbers of living patients
- disease free survival as a measure by the number of patients without recurrence or death
- local recurrence free survival as a measure by the number of patients without recurrence
- distant metastasis free survival as a measure by the number of patients without metastasis
|
48 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02290145 |
CDSCAN |
|
December 2016 |
December 2018 |
December 2019 |
November 13, 2014 |
August 21, 2017 |
|
- Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai, China
|
| 17 |
NCT01946230 |
Unknown † |
The Study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma |
- Oral Potentially Malignant Disorder
- Oral Cancer
- Malignant Disorder
- p62/SQSTM1
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Time Perspective: Prospective
|
- The study of p62/SQSTM1 as a Malignant Transformation Marker for Oral Potentially Malignant Disorders and a Prognostic Marker for Oral Squamous Cell Carcinoma
|
2000 |
All |
20 Years to 90 Years (Adult, Senior) |
NCT01946230 |
201306005RINC |
p62/SQSTM1 |
June 2014 |
August 2014 |
|
September 19, 2013 |
April 28, 2014 |
|
|
| 18 |
NCT03026361 |
Completed |
Molecular Mechanisms of the Development of Precancerous and Cancerous Lesions of the Oral Cavity |
- Oral Lichen Planus
- Oral Squamous Cell Carcinoma
|
- Genetic: global proteomic profiling
|
Observational |
|
- University of Zagreb
- University of Rijeka
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Global proteomic profiling of oral lichen planus and oral squamous cell carcinoma
- evaluation of the Insulin-like growth factor receptor 2 (IGF2R) and IGF2 role in oral lichen planus
|
71 |
All |
30 Years to 70 Years (Adult, Senior) |
NCT03026361 |
06509824642532 |
|
January 2010 |
December 2014 |
December 2014 |
January 20, 2017 |
January 20, 2017 |
|
- School of Dental Medicine, University of Zagreb
Zagreb, Croatia
|
| 19 |
NCT03418454 |
Recruiting |
The Oral Microbiome as a Prognostic Tool in Oral Malignant and Premalignant Lesions and in Medication Related Osteonecrosis of the Jaw |
- Oral Squamous Cell Carcinoma
- Medication Related Osteonecrosis of the Jaw
- Oral Epithelial Dysplasia
|
- Diagnostic Test: Buccal mucosa samples for Extraction of BACTERIAL DNA
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Microbiome characterization day 1 of the study
- Microbiome characterization month 3 of the study
- Microbiome characterization month 6 of the study
- (and 2 more...)
|
150 |
All |
20 Years to 90 Years (Adult, Senior) |
NCT03418454 |
BRZ 0062-17 CTIL |
|
December 14, 2017 |
December 31, 2021 |
December 31, 2021 |
February 1, 2018 |
March 9, 2018 |
|
- Barzilai medical Center
Ashkelon, Israel
|
| 20 |
NCT00173849 |
Unknown † |
The Role of SDF-1/CXCR4 in Metastasis of Oral Squamous Cell Carcinoma |
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Allocation: Random Sample
- Observational Model: Natural History
- Time Perspective: Longitudinal
- Time Perspective: Retrospective/Prospective
|
|
100 |
All |
30 Years to 75 Years (Adult, Senior) |
NCT00173849 |
9461700656 |
|
January 2006 |
|
July 2006 |
September 15, 2005 |
September 15, 2005 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
| 21 |
NCT03385720 |
Active, not recruiting |
Submandibular Gland Preservation in Neck Dissection |
- Neck Dislocation
- Oral Cancer
|
- Procedure: modified neck dissection
- Procedure: traditional neck dissection
|
Interventional |
Not Applicable |
- Guang-Yan Yu
- Jia-Zeng Su
- Peking University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- 5-year survival rate
- 3-year survival rate
- 5-year regional recurrence rate
- (and 2 more...)
|
200 |
All |
Child, Adult, Senior |
NCT03385720 |
sujiazeng |
|
December 5, 2017 |
December 2020 |
December 2030 |
December 28, 2017 |
December 28, 2017 |
|
- Peking University School of Stomatology
Beijing, Beijing, China
|
| 22 |
NCT02323672 |
Completed |
Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions |
- Precancerous Conditions
- Oral Cancer
|
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- salivary levels of chemerin in patients with oral premalignant and malignant lesions.
- serum levels of chemerin in patients with oral premalignant and malignant lesions.
- serum levels of MMP-9 in patients with oral premalignant and malignant lesions.
- salivary levels of MMP-9 in patients with oral premalignant and malignant lesions.
|
45 |
All |
40 Years to 50 Years (Adult) |
NCT02323672 |
chemerin_MMP-9_Oral_cancer |
|
February 2014 |
September 2014 |
October 2014 |
December 23, 2014 |
February 10, 2017 |
|
|
| 23 |
NCT02285543 |
Active, not recruiting |
A Phase II Trial of TPF Induction Chemotherapy in cN2 OSCC Patients |
- Mouth Neoplasms
- Carcinoma, Squamous Cell
|
- Drug: TPF induction chemotherapy
- Procedure: surgery
- Radiation: radiotherapy
|
Interventional |
Phase 2 |
- Shanghai Jiao Tong University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- overall survival rate as a measure by the numbers of living patients overall Survival rate
- disease free survival as a measure by the number of patients without recurrence or death
- local recurrence free survival as a measure by the number of patients without recurrence
- distant metastasis free survival as a measure by the number of patients without metastasis
|
101 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02285543 |
TOPIC |
|
December 2016 |
December 2020 |
December 2021 |
November 7, 2014 |
August 21, 2017 |
|
- Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai, China
|
| 24 |
NCT00693550 |
Completed |
Contact Allergies to Dental Metal as a Possible Risk Factor for Oral Cancer |
|
|
Observational |
|
- Mayo Clinic
- National Cancer Institute (NCI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Relationship between intraoral metal contact allergy and epithelial carcinogenesis
- Prevalence of metal contact allergy comparison to study control data
|
115 |
All |
18 Years and older (Adult, Senior) |
NCT00693550 |
497-00
P30CA015083
CDR0000589036 |
|
August 2000 |
January 2009 |
January 2009 |
June 9, 2008 |
June 8, 2011 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
| 25 |
NCT02285530 |
Recruiting |
GDF15 Based TPF Induction Chemotherapy for OSCC Patients |
- Mouth Neoplasms
- Carcinoma, Squamous Cell
|
- Drug: TPF induction chemotherapy
- Procedure: surgery group
- Radiation: Post-operative radiotherapy
|
Interventional |
Phase 2 |
- Shanghai Jiao Tong University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- overall survival rate as a measure by the numbers of living patients
- disease free survival as a measure by the number of patients without recurrence or death
- local recurrence free survival as a measure by the number of patients without recurrence
- distant metastasis free survival as a measure by the number of patients without metastasis
|
72 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02285530 |
GOSCAN |
|
December 2016 |
December 2020 |
December 2021 |
November 7, 2014 |
August 21, 2017 |
|
- Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai, China
|
| 26 |
NCT01465776 |
Completed |
Freeze-Dried Black Raspberries in Treating Patients With Oral Squamous Cell Cancer Undergoing Surgery |
- Squamous Cell Carcinoma of Mouth
|
- Other: laboratory biomarker analysis
- Other: preventative dietary intervention
|
Interventional |
Not Applicable |
- Amit Agrawal
- Ohio State University Comprehensive Cancer Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Relationship between the length of short-term LBR administration to human oral cancer patients and the modulation, in oral cavity tissues, of LBR-responsive genes
- Evaluate effects of lyophilized freeze-dried black raspberries (LBR) administration in humans on cell proliferation, apoptosis, and angiogenesis in oral cavity tissues using various established biomarkers.
- Assess feasibility of administering lyophilized freeze-dried black raspberries in oral troche form to pre-surgical patients diagnosed with squamous cell carcinoma of the oral cavity.
|
38 |
All |
18 Years and older (Adult, Senior) |
NCT01465776 |
OSU-0497
NCI-2011-02684 |
|
January 10, 2005 |
February 16, 2010 |
February 16, 2010 |
November 7, 2011 |
March 6, 2018 |
|
- Ohio State University Medical Center
Columbus, Ohio, United States
|
| 27 |
NCT00009841 |
Completed |
Gene Therapy in Treating Patients With Advanced Head and Neck Cancer |
|
- Biological: EGFR antisense DNA
- Biological: growth factor antagonist therapy
- Drug: DC-cholesterol liposome
|
Interventional |
Phase 1 |
- University of Pittsburgh
- National Cancer Institute (NCI)
|
Other / NIH |
- Primary Purpose: Treatment
|
|
13 |
All |
18 Years to 120 Years (Adult, Senior) |
NCT00009841 |
PCI-98025
CDR0000068414
PCI-IRB-980771
NCI-G00-1904 |
|
March 1999 |
March 2002 |
March 2002 |
April 2, 2004 |
February 12, 2016 |
|
- University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania, United States
|
| 28 |
NCT00571883 |
Unknown † |
Neck Surgery in Treating Patients With Early-Stage Oral Cancer |
|
- Other: questionnaire administration
- Procedure: psychosocial assessment and care
- Procedure: quality-of-life assessment
- (and 2 more...)
|
Interventional |
Not Applicable |
- The Facial Surgery Research Foundation
- National Cancer Institute (NCI)
|
Other |
- Allocation: Randomized
- Primary Purpose: Treatment
|
- Overall survival
- Disease-free survival
- Local and regional recurrence
- (and 5 more...)
|
652 |
All |
16 Years to 120 Years (Child, Adult, Senior) |
NCT00571883 |
CDR0000577728
FSRF-SEND-001
EU-20794 |
|
January 2007 |
December 2015 |
|
December 12, 2007 |
December 14, 2015 |
|
- Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust
Birmingham, England, United Kingdom - Cumberland Infirmary
Carlisle, England, United Kingdom - Queen Alexandra Hospital
Cosham, England, United Kingdom - (and 24 more...)
|
| 29 |
NCT02748707 |
Recruiting |
Effect of COX-2 and EGFR Suppression on Molecular Markers of Angiogenesis and Proliferation in Squamous Cell Carcinoma of Oral Cavity - Prospective Randomized Study |
- Oral Squamous Cell Carcinoma
- Carcinoma of Buccal Mucosa
- Tongue Cancers
- Head and Neck Cancers
|
- Drug: Arm1
- Drug: Arm 2
- Drug: Arm 3
- Other: Arm 4
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in expression of selected biomarkers in tissue samples, assessed by immunohistochemistry (IHC) and PCR
- Clinical and radiological Change in tumor size and appearance
|
64 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02748707 |
830 |
ERLO-XIB |
August 2015 |
August 2018 |
August 2020 |
April 22, 2016 |
November 9, 2016 |
|
- Tata Memorial Center (TMC)
Mumbai, Maharashtra, India
|
| 30 |
NCT01772706 |
Recruiting |
Laser Mucite ORL : Effectiveness of Laser Therapy for Mucositis Induced by a Radio-chemotherapy in Head and Neck Cancer |
- Oral Squamous Cell Carcinoma
- Squamous Cell Carcinoma of Oropharynx
- Squamous Cell Carcinoma of Hypopharynx
- Oral Mucositis
|
- Procedure: low level laser therapy
- Procedure: placebo (laser low level energy nonfunctional)
|
Interventional |
Phase 3 |
- Institut Cancerologie de l'Ouest
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To evaluate the efficacy of preventive and curative low energy laser induced mucositis in patients receiving concomitant chemotherapy and radiotherapy for squamous cell carcinoma of the head and neck with stage III-IV
- To evaluate the pain by a numerical analog, in its the nature and the dosage of analgesics consumed.
- To assess the nutritional status by body weight follow-up and the capability of swallowing various foods, and biologically the serum albumin, prealbumin, and optionally a measure of body fat (impedance, skinfolds)
- (and 3 more...)
|
100 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT01772706 |
CPP400
2008-003681-26 |
LaserMucite |
October 2008 |
March 2019 |
|
January 21, 2013 |
January 21, 2013 |
|
- Institut de Cancerologie de l'Ouest Paul Papin
Angers, France - Centre Guillaume le Conquérant
Le Havre, France - Hôpital La Pitié Salpêtrière
Paris, France - (and 3 more...)
|
| 31 |
NCT00835341 |
Completed
Has Results |
Methylation of p16 CpG Island And Malignant Transformation of Oral Epithelial Dysplasia |
- Oral Epithelial Dysplasia, Mild or Moderate Grade
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The Number of Participants With Both Clinical and Histological Evidence of Malignant Transformation of Oral Epithelial Dysplasia
- Cancer-free Survival Time for Patients With Oral Epithelial Dysplasia
|
93 |
All |
Child, Adult, Senior |
NCT00835341 |
CPDHS-434 |
|
March 2005 |
October 2008 |
October 2008 |
February 3, 2009 |
June 1, 2015 |
February 23, 2010 |
- Department of Oral Medicine, Peking University School and Hospital of Stomatology
Beijing, China
|
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