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52 studies found for:    "Lynch syndrome"
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Rank Status Study
21 Terminated Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome
Conditions: Endometrial Cancer;   Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)
Interventions: Device: levonorgestrel-releasing intrauterine system;   Other: questionnaire administration;   Procedure: observation
22 Recruiting Survivorship in Lynch Syndrome Families
Condition: Colorectal Cancer
Interventions: Behavioral: Telephone Interview;   Behavioral: Questionnaire
23 Completed Uncertain Genetic Test Results for Lynch Syndrome
Condition: HNPCC
24 Not yet recruiting Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair or Microsatellite Instability
Conditions: Colon Adenocarcinoma;   DNA Repair Disorder;   Lynch Syndrome;   Microsatellite Instability;   Stage IIIA Colon Cancer;   Stage IIIB Colon Cancer;   Stage IIIC Colon Cancer
Interventions: Drug: Atezolizumab;   Drug: Fluorouracil;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin;   Other: Quality-of-Life Assessment
25 Enrolling by invitation Identifying Patients With Hereditary and Familial Colorectal Cancer by Using an Online Risk Tool
Conditions: Colorectal Cancer;   Lynch Syndrome;   Familial Colorectal Cancer
Intervention: Other: Offering an online risk assessment questionnaire
26 Suspended Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, or Hypermutated Brain Tumors
Conditions: Diffuse Intrinsic Pontine Glioma;   Lynch Syndrome;   Malignant Glioma;   Mismatch Repair Gene Inactivation;   Recurrent Childhood Brain Neoplasm;   Refractory Brain Neoplasm
Interventions: Procedure: Diffusion Tensor Imaging;   Procedure: Diffusion Weighted Imaging;   Procedure: Dynamic Contrast-Enhanced Magnetic Resonance Imaging;   Procedure: Dynamic Susceptibility Contrast-Enhanced Magnetic Resonance Imaging;   Other: Laboratory Biomarker Analysis;   Procedure: Magnetic Resonance Spectroscopic Imaging;   Biological: Pembrolizumab;   Procedure: Perfusion Magnetic Resonance Imaging
27 Recruiting Cancer Research Repository for Individuals With Cancer Diagnosis and High Risk Individuals.
Conditions: Pancreatic Cancer;   Thyroid Cancer;   Lung Cancer;   Esophageal Cancer;   Thymus Cancer;   Colon Cancer;   Rectal Cancer;   GIST;   Anal Cancer;   Bile Duct Cancer;   Duodenal Cancer;   Gallbladder Cancer;   Gastric Cancer;   Liver Cancer;   Small Intestine Cancer;   Peritoneal Surface Malignancies;   Familial Adenomatous Polyposis;   Lynch Syndrome;   Bladder Cancer;   Kidney Cancer;   Penile Cancer;   Prostate Cancer;   Testicular Cancer;   Ureter Cancer;   Urethral Cancer;   Hypopharyngeal Cancer;   Laryngeal Cancer;   Lip Cancer;   Oral Cavity Cancer;   Nasopharyngeal Cancer;   Oropharyngeal Cancer;   Paranasal Sinus Cancer;   Nasal Cavity Cancer;   Salivary Gland Cancer;   Skin Cancer;   CNS Tumor;   CNS Cancer;   Mesothelioma
28 Not yet recruiting Biomarkers in Samples From Patients With Endometrial Cancer
Conditions: Lynch Syndrome;   Recurrent Uterine Corpus Carcinoma;   Stage I Uterine Corpus Cancer;   Stage II Uterine Corpus Cancer;   Stage III Uterine Corpus Cancer;   Stage IV Uterine Corpus Cancer
Intervention: Other: Laboratory Biomarker Analysis
29 Recruiting Hereditary Colorectal and Associated Tumor Registry Study
Conditions: Lynch Syndrome;   FAP;   Hereditary Diffuse Gastric Cancer;   Juvenile Polyposis Syndrome;   Peutz-Jeghers Syndrome
Intervention: Other: Research Registry
30 Completed Telemedicine vs. Face-to-Face Cancer Genetic Counseling
Conditions: Hereditary Breast and Ovarian Cancer Syndrome;   Lynch Syndrome
Interventions: Other: Telemedicine;   Other: Face-to-Face
31 Active, not recruiting Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Bevacizumab in Treating Patients Who Have Undergone Surgery for Stage II Colon Cancer
Conditions: Colon Mucinous Adenocarcinoma;   Colon Signet Ring Cell Adenocarcinoma;   Lynch Syndrome;   Stage IIA Colon Cancer;   Stage IIB Colon Cancer;   Stage IIC Colon Cancer
Interventions: Biological: Bevacizumab;   Drug: Fluorouracil;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Oxaliplatin
32 Completed Psychosocial Aspects of Genetic Testing for Hereditary Nonpolyposis Colon Cancer
Conditions: HNPCC;   Hereditary Nonpolyposis Colon Cancer
33 Not yet recruiting Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome
Condition: Colorectal Neoplasms, Hereditary Nonpolyposis
Interventions: Drug: Mesalamine 1600 mg QD;   Drug: Mesalamine 3200 mg QD;   Drug: Placebo
34 Completed Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance
Condition: Colorectal Neoplasms, Hereditary Nonpolyposis
Intervention: Procedure: Narrow Band Imaging
35 Active, not recruiting Dendritic Cell Vaccination in Patients With Lynch Syndrome or Colorectal Cancer With MSI
Condition: Colorectal Cancer
Intervention: Biological: DC vaccination
36 Completed
Has Results
Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer
Conditions: Colorectal Cancer;   Hereditary Non-polyposis Colon Cancer
Interventions: Other: counseling intervention;   Other: CD-ROM intervention
37 Unknown  Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer
Conditions: Colorectal Cancer;   Hereditary Nonpolyposis Colorectal Cancer;   Precancerous Condition
Interventions: Other: study of socioeconomic and demographic variables;   Procedure: evaluation of cancer risk factors;   Procedure: study of high risk factors
38 Recruiting The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)
Conditions: Bladder Cancer;   Colorectal Cancer;   Endometrial Cancer;   Kidney Cancer;   Skin Cancer;   Uterus Cancer
Intervention: Behavioral: Health and Diet Questionnaire
39 Completed Screening for Gynecologic Cancers in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Patients
Condition: Colon Cancer
Intervention: Behavioral: Questionnaire
40 Unknown  Implementation of a New Strategy to Identify HNPCC Patients
Conditions: Colorectal Neoplasms;   Hereditary Nonpolyposis Colorectal Cancer
Interventions: Behavioral: Education for professionals;   Behavioral: Distribution of educational materials;   Behavioral: Feedback for professionals;   Behavioral: Reminders for professionals

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Indicates status has not been verified in more than two years