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43 studies found for:    "Li Fraumeni syndrome"
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Study Details
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Dates
Rank Status Study
1 Recruiting Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Intervention:
2 Active, not recruiting Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Interventions: Other: Whole body MRI;   Other: Psychological questionnaires
3 Recruiting Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition Syndromes
Condition: Li-Fraumeni Syndrome
Intervention: Device: Whole Body MRI
4 Active, not recruiting A Pilot Study of Metformin in Patients With a Diagnosis of Li-Fraumeni Syndrome
Condition: Li-Fraumeni Syndrome
Intervention: Drug: Metformin
5 Recruiting LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)
Condition: Li Fraumeni Syndrome
Intervention: Other: whole body MRI
6 Recruiting Clinical and Genetic Studies of Li-Fraumeni Syndrome
Conditions: Li-Fraumeni Syndrome;   Neoplasms;   Tp53 Mutations
Intervention:
7 Unknown  p53 Gene Therapy for Head and Neck Malignant Tumors in Advanced Stage
Condition: Neoplasms
Interventions: Drug: chemotherapy plus p53;   Drug: chemotherapy;   Radiation: radiotherapy
8 Active, not recruiting Biomarker Monitoring in TP53 Mutation Carriers
Conditions: Li-Fraumeni Syndrome;   Hereditary Cancer Syndromes;   TP53 Gene Germline Mutation Carrier
Intervention:
9 Unknown  rAd-p53 Gene Therapy for Advanced Oral and Maxillofacial Malignant Tumors
Condition: Advanced Oral and Maxillofacial Malignant Tumors
Interventions: Drug: p53 gene with surgery;   Procedure: surgery;   Drug: p53 with chemotherapy;   Drug: p53 gene therapy
10 Unknown  Surgery Combined With rAd-p53 Gene in Treatment Advanced Non-small-cell Carcinoma
Condition: Non-small Cell Lung Cancer
Interventions: Drug: Surgery combined with rAd-p53 gene therapy;   Procedure: Surgery
11 Not yet recruiting Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural Effusion
Condition: Malignant Pleural Effusion
Interventions: Drug: rAdp53;   Drug: Cisplatin;   Drug: rAdp53 plus cisplatin
12 Unknown  rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors
Condition: Advanced Malignant Thyroid Tumors
Interventions: Drug: rAd-p53 gene;   Procedure: surgery;   Drug: p53 gene therapy;   Radiation: p53 gene therapy with radioactive iodine
13 Not yet recruiting p53 Gene Therapy in Treatment of Diabetes Concurrent With Hepatocellular Carcinoma
Conditions: HCC;   Diabetes
Interventions: Drug: p53 gene therapy;   Drug: Trans-catheter embolization
14 Not yet recruiting P53 Gene Combined With Radio- and Chemo-therapy in Treatment of Unresectable Locally Advanced Head and Neck Cancer
Condition: Advanced Head and Neck Cancer
Interventions: Drug: rAd-p53;   Radiation: radiation;   Drug: Cisplatin
15 Recruiting Trans-catheter Arterial Embolization Combined With p53 Gene Therapy for Treatment of Advanced Hepatocellular Carcinoma
Condition: Advanced Hepatocellular Carcinoma (HCC)
Interventions: Drug: TAE plus P53 gene;   Other: TAE
16 Recruiting Trans-catheter Chemo-embolization Combined With rAd-p53 Gene Injection in Treatment of Advanced Hepatocellular Carcinoma
Condition: Advanced Adult Hepatocellular Carcinoma
Interventions: Drug: TACE plus rAd-p53 artery injection;   Drug: TACE
17 Recruiting Study to Determine and Evaluate a Safe and Tolerated Dose of HDM201 in Patients With Selected Advanced Tumors That Are TP53wt
Condition: Advanced Solid and Hematological TP53wt Tumors
Interventions: Drug: HDM201;   Drug: ancillary treatment
18 Not yet recruiting p53 Gene in Treatment of Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, and Primary Peritoneal Cancer
Conditions: Ovarian Epithelial Cancer;   Fallopian Tube Cancer;   Primary Peritoneal Cancer
Interventions: Drug: p53 gene;   Drug: Cisplatin;   Drug: Paclitaxel
19 Recruiting A Study Evaluating Venetoclax in Subjects With Chronic Lymphocytic Leukemia Whose Cancer Has Come Back or Who Had No Response to Previous Cancer Treatments Including Subjects Missing Part of Their Chromosome 17, or TP53 Gene Mutation; or Who Received Prior Treatment With a B-Cell Receptor Inhibitor
Condition: Chronic Lymphocytic Leukemia (CLL)
Intervention: Drug: Venetoclax
20 Completed Biomarker (p53 Gene) Analysis and Combination Chemotherapy Followed by Radiation Therapy and Surgery in Treating Women With Large Operable or Locally Advanced or Inflammatory Breast Cancer
Condition: Breast Cancer
Interventions: Biological: filgrastim;   Drug: cyclophosphamide;   Drug: docetaxel;   Drug: epirubicin hydrochloride;   Drug: fluorouracil;   Genetic: microarray analysis;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis;   Procedure: biopsy;   Procedure: conventional surgery;   Procedure: neoadjuvant therapy;   Radiation: radiation therapy

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Study has passed its completion date and status has not been verified in more than two years.