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43 studies found for:    "Li Fraumeni syndrome"
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Rank Status Study
21 Completed A Study of MK-1775 in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004)
Condition: Ovarian Cancer
Interventions: Drug: MK-1775;   Drug: Placebo;   Drug: paclitaxel;   Drug: carboplatin
22 Terminated Wild Type p53 Adenovirus for Oral Premalignancies
Condition: Mouth Cancer
Intervention: Genetic: INGN 201
23 Completed Gene Therapy in Treating Patients With Recurrent Malignant Gliomas
Condition: Brain and Central Nervous System Tumors
Interventions: Biological: Ad5CMV-p53 gene;   Procedure: conventional surgery
24 Recruiting Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients
Conditions: Polycythemia Vera;   Essential Thrombocythemia
Intervention: Procedure: Blood specimen
25 Completed Genetic Polymorphisms Associated With Cigarette Smoking and Risk of Graves’ Disease
Condition: Graves' Disease
Intervention:
26 Unknown  Gene Therapy in Treating Patients With Advanced Recurrent or Persistent Ovarian Cancer or Primary Peritoneal Cancer
Conditions: Ovarian Cancer;   Peritoneal Cavity Cancer
Intervention: Biological: Ad5CMV-p53 gene
27 Recruiting Phase II Study of Combined Temozolomide and SGT-53 for Treatment of Recurrent Glioblastoma
Condition: GLIOBLASTOMA
Interventions: Genetic: SGT-53;   Drug: Temozolomide
28 Recruiting Study of Combined SGT-53 Plus Gemcitabine/Nab-Paclitaxel for Metastatic Pancreatic Cancer
Condition: Metastatic Pancreatic Cancer
Interventions: Genetic: SGT-53;   Drug: nab-paclitaxel;   Drug: Gemcitabine
29 Recruiting p53 and Response to Preoperative Radiotherapy for T2 and T3
Condition: Rectal Cancer
Intervention: Radiation: preoperative short course radiation
30 Unknown  Duct Endoscopy in Assessing Cellular Atypia in the Breast Duct Fluid of Women With a Genetic Risk for Breast Cancer
Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis;   Genetic: proteomic profiling;   Other: cytology specimen collection procedure;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis;   Procedure: breast duct lavage
31 Recruiting ALRN-6924 in Patients With Advanced Solid Tumors or Lymphomas
Conditions: Solid Tumor;   Lymphoma;   Peripheral T-Cell Lymphoma
Intervention: Drug: ALRN-6924
32 Completed Chemotherapy Followed By Vaccine Therapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer
Condition: Lung Cancer
Interventions: Biological: Autologous dendritic cell-adenovirus p53 vaccine;   Drug: Carboplatin;   Drug: Etoposide
33 Completed Gene Therapy in Preventing Cancer in Patients With Premalignant Carcinoma of the Oral Cavity or Pharynx
Conditions: Lip and Oral Cavity Cancer;   Oropharyngeal Cancer;   Stage 0 Lip and Oral Cavity Cancer;   Stage 0 Oropharyngeal Cancer;   Tongue Cancer
Interventions: Biological: Ad5CMV-p53 gene;   Other: laboratory biomarker analysis
34 Active, not recruiting
Has Results
To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic Acid
Condition: Small Cell Lung Cancer
Interventions: Drug: Paclitaxel;   Biological: Drug: Ad.p53-DC vaccines;   Drug: All -trans Retinoic Acid (ATRA)
35 Completed P53 in Differentiated Thyroid Cancer
Condition: Thyroid Neoplasms
Intervention:
36 Recruiting Trial of Adoptive T Cell Therapy With Activated P53 Specific T Cells for Treatment of Advanced Colorectal Cancer
Condition: Colorectal Carcinoma
Intervention: Biological: re-activated T cells
37 Withdrawn Aezea® (Cenersen) and Chemotherapy for AML Subjects ≥ 55 Years of Age With No Response to Frontline Induction Course
Condition: Acute Myelogenous Leukemia
Interventions: Drug: cenersen;   Drug: placebo;   Drug: idarubicin, cytarabine
38 Completed QUILT-2.008: Study of ALT-801 With Cisplatin in Patients With Metastatic Melanoma
Condition: Metastatic Melanoma
Interventions: Drug: Cisplatin;   Biological: ALT-801
39 Completed
Has Results
Safety and Efficacy Study of ALT-801 to Treat Progressive Metastatic Malignancies
Condition: Progressive Metastatic Malignancies
Intervention: Biological: ALT-801
40 Active, not recruiting Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
Conditions: Familial Ovarian Cancer;   Familial Breast Cancer;   BRCA1-associate Malignancies;   BRCA2-associated Malignancies
Intervention:

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Study has passed its completion date and status has not been verified in more than two years.