| 1 |
NCT02582853 |
Unknown † |
sCD163 as a Potential Biomarker in Guillain- Barré Syndrome |
|
- Procedure: Lumbar puncture
- Procedure: Blood Sample
|
Observational |
|
|
Other |
|
- Concentration of sCD163 in patients with GBS
- Concentration of sCD163 in patients with GBS after treatment
|
60 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT02582853 |
GBS CD163
1-10-72-256-15
1-16-02-522-15 |
GBS |
September 2015 |
November 2016 |
January 2018 |
October 21, 2015 |
October 22, 2015 |
|
- The Department of Neurology, Aarhus University Hospital
Aarhus C, Denmark
|
| 2 |
NCT02780570 |
Completed |
Small Volume Plasma Exchange (SVPE) for Guillain-Barré Syndrome (GBS) Patients |
|
- Procedure: Small Volume Plasma Exchange
|
Interventional |
Phase 2 |
- International Centre for Diarrhoeal Disease Research, Bangladesh
- GBS-CIDP Foundation International
- National Institute of Neuroscience, Dhaka, Bangladesh
- Erasmus Medical Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants in whom up to eight liters of plasma could be removed
- Number of participants who complete forty sessions of SVPE
- Number of patients developing severe sepsis or septic shock due to CLABSI in SVPE treated GBS patients
- (and 10 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT02780570 |
PR-15086 |
|
January 1, 2016 |
December 31, 2016 |
December 31, 2016 |
May 23, 2016 |
July 27, 2017 |
|
- National Institute of Neuroscience
Dhaka, Bangladesh
|
| 3 |
NCT01306578 |
Completed |
Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS) |
|
- Drug: IVIG
- Procedure: Plasma Exchange
|
Interventional |
Not Applicable |
- Mansoura University Children Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Duration of mechanical ventilation
- PICU stay
- Ability to walk
|
41 |
All |
1 Month to 18 Months (Child) |
NCT01306578 |
MUCH-GBS |
|
January 2007 |
December 2009 |
February 2010 |
March 2, 2011 |
March 2, 2011 |
|
- Mansoura University Children Hospital
Mansoura, Dakahlia, Egypt
|
| 4 |
NCT02342184 |
Completed |
Efficacy and Safety Study of GB-0998 for Guillain-Barré Syndrome |
|
|
Interventional |
Phase 3 |
- Japan Blood Products Organization
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of patients with more than 1 grade improvement in Hughes Functional Grade (FG)
- days required for 1 grade improvement of FG
- days required for 2 grade improvement of FG
- (and 10 more...)
|
21 |
All |
16 Years and older (Child, Adult, Senior) |
NCT02342184 |
B211-13 |
|
August 2014 |
September 2015 |
September 2015 |
January 19, 2015 |
February 4, 2016 |
|
- Department of Neurology, Saitama Medical Center, Saitama Medical University
Kawagoe, Saitama, Japan
|
| 5 |
NCT00173199 |
Unknown † |
The Changes of Cytokines in Guillain Barré Syndrome: the Correlation With Clinical Manifestations and Skin Innervation |
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Defined Population
- Primary Purpose: Screening
- Time Perspective: Cross-Sectional
- Time Perspective: Prospective
|
|
150 |
All |
Child, Adult, Senior |
NCT00173199 |
9461700526 |
|
June 2005 |
|
|
September 15, 2005 |
December 1, 2005 |
|
- Department of Anatomy and Cell Biology, National Taiwan University College of Medicine
Taipei, Taiwan
|
| 6 |
NCT01582763 |
Recruiting |
International Guillain-Barré Syndrome Outcome Study |
- Guillain-Barré Syndrome
- Miller Fisher Syndrome
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Guillain-Barre Syndrome(GBS) disability score and Medical Research Council(MRC) sumscore
- Overall Neuropathy Limitations Scale (ONLS)
- Fatigue Severity Scale (FSS)
- (and 2 more...)
|
4000 |
All |
Child, Adult, Senior |
NCT01582763 |
MEC-2011-477
3290 |
IGOS |
May 2012 |
June 2017 |
January 2019 |
April 23, 2012 |
January 5, 2017 |
|
- Barrows Neurological Institute
Phoenix, Arizona, United States - UC Irvine Health
Orange, California, United States - Yale University School of medicine
New Haven, Connecticut, United States - (and 125 more...)
|
| 7 |
NCT00056810 |
Completed |
Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-aminopyridine |
|
- Drug: 4-aminopyridine (4-AP)
|
Interventional |
Phase 2 |
- FDA Office of Orphan Products Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double
|
- American Spinal Injury Association (ASIA) Motor Score at 8 weeks and 19 weeks
- Functional Independence Measure (FIM) Motor scale at 8 weeks and 19 weeks
- The following are all at 8 weeks and 19 weeks: Hand Dynamometer
- (and 11 more...)
|
30 |
All |
19 Years to 75 Years (Adult, Senior) |
NCT00056810 |
2129 |
|
September 2002 |
|
May 2005 |
March 25, 2003 |
March 25, 2015 |
|
- Rehabilitation Institute of Michigan at Detroit Medical Center
Detroit, Michigan, United States
|
| 8 |
NCT02459808 |
Withdrawn |
Gastrointestinal Transit Time in Patients With Guillain-Barré Syndrome |
- Guillain-Barre Syndrome
- Constipation
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Gastrointestinal transit time (GITT) [in days]
- Association between heart rate variability (HRV) and GITT
|
0 |
All |
18 Years to 79 Years (Adult, Senior) |
NCT02459808 |
GBSTransitTimeAarhus |
|
May 2015 |
May 2018 |
|
June 2, 2015 |
January 23, 2018 |
|
- Aarhus University Hospital
Aarhus C, Denmark
|
| 9 |
NCT02221271 |
Completed |
Phase III Clinical Trial of NPB-01 in Patients With Guillain-Barré Syndrome |
|
|
Interventional |
Phase 3 |
- Nihon Pharmaceutical Co., Ltd
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- proportion of patients with more than 1grade improvement in the Hughes functional grading scale(FG) relative to baseline at 4weeks.
- days required for 1 grade improvement of the Hughes functional grading scale(FG)
- days required for 2 grade improvement of the Hughes functional grading scale(FG)
- (and 9 more...)
|
22 |
All |
18 Years and older (Adult, Senior) |
NCT02221271 |
NPB-01-13/C-01 |
|
October 2014 |
August 2015 |
August 2015 |
August 20, 2014 |
April 12, 2017 |
|
- Nihon Pharmaceutical Co., Ltd
Osaka, Japan
|
| 10 |
NCT00575653 |
Completed |
Safety Study of GBS Following Menactra Meningococcal Vaccination |
|
|
Observational |
|
- Harvard Pilgrim Health Care
- Aetna, Inc.
- HealthCore, Inc.
- (and 3 more...)
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Guillain-Barré syndrome (GBS), verified through neurologist review of medical records
- Clinical presentation and severity of GBS
|
6000000 |
All |
11 Years to 21 Years (Child, Adult) |
NCT00575653 |
PH000274A |
|
March 2005 |
December 31, 2009 |
December 31, 2010 |
December 18, 2007 |
March 16, 2017 |
|
- HealthCore, Inc.
Wilmington, Delaware, United States - Kaiser Permanente Center for Health Research Hawaii
Honolulu, Hawaii, United States - Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care
Boston, Massachusetts, United States - (and 3 more...)
|
| 11 |
NCT00004833 |
Terminated |
Randomized Study of Plasmapheresis or Human Immunoglobulin Infusion in Childhood Guillain-Barre Syndrome |
|
|
Interventional |
Not Applicable |
- Emory University
- FDA Office of Orphan Products Development
|
Other |
- Allocation: Randomized
- Primary Purpose: Treatment
|
|
170 |
All |
up to 17 Years (Child) |
NCT00004833 |
199/13444
EUSM-076-97
EUSM-FDR001265 |
|
July 1995 |
|
November 2002 |
February 25, 2000 |
April 7, 2015 |
|
|
| 12 |
NCT00167622 |
Completed |
Early Mechanical Ventilation for Guillain Barré Syndrome |
- Guillain Barré Syndrome
- Acute Respiratory Failure
|
- Procedure: mechanical ventilation
- Procedure: physiotherapy and oxygen if needed
|
Interventional |
Phase 2 |
- University of Versailles
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Rate of hospital acquired pneumonia from randomization to study day 90
- Time on a ventilator
- Intensive care unit lenght of stay
- (and 2 more...)
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT00167622 |
P050103
PS050103 |
|
April 2005 |
January 2009 |
February 2009 |
September 14, 2005 |
July 20, 2016 |
|
- Raymond Poincaré Hospital
Garches, France
|
| 13 |
NCT02883270 |
Completed |
Effects of Robotic-assisted Gait Training In Non-Ambulatory Patients After Guillain-Barré Syndrome |
|
- Device: Robot-assisted Gait Training
- Other: conventional rehabilitation
|
Interventional |
Not Applicable |
- Junwei Hao
- Tianjin Medical University General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
24 |
All |
18 Years to 65 Years (Adult) |
NCT02883270 |
IRB2016-039-01 |
|
August 2014 |
August 2016 |
August 2016 |
August 30, 2016 |
September 2, 2016 |
|
- Tianjin Medical University General Hospital
TianJin, Tianjin, China
|
| 14 |
NCT01024088 |
Completed |
Prospective Study on Swallowing/Breathing Interactions in Severe Guillain Barre Syndrome. |
- Tetraplegia
- Respiratory Failure
|
|
Observational |
|
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Time Perspective: Prospective
|
- Correlation between respiratory failure and bulbar dysfunction during ICU stay
- Number of aspiration pneumonia
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT01024088 |
P061016 -CRC 06040 |
DGVSB |
March 2008 |
July 2012 |
July 2012 |
December 2, 2009 |
September 16, 2014 |
|
- hôpital Raymond Poincaré
Garches, France
|
| 15 |
NCT02029378 |
Unknown † |
Inhibition of Complement Activation (Eculizumab) in Guillain-Barre Syndrome Study |
|
|
Interventional |
Phase 2 |
- NHS Greater Glasgow and Clyde
- University of Glasgow
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Determine the incidence of AE/SAEs after treatment with eculizumab and IVIg compared to placebo controls
- Improvement of one or more grade in functional outcome (on the 6 point GBS disability scale) at 4 weeks
- Ability to walk unaided (GBS disability score 2) at 8 weeks
- (and 9 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02029378 |
GN12NE462 |
ICA-GBS |
September 2014 |
October 2015 |
March 2016 |
January 7, 2014 |
September 23, 2014 |
|
- Southern General Hospital
Glasgow, United Kingdom
|
| 16 |
NCT01005524 |
Completed |
Brain Computer Interface for Communication in ICU: a Feasibility Study |
- Tetraplegia
- Guillain-Barre Syndrome
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
12 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01005524 |
ANR-TecSan-2009
AFM2009 |
RoBIK-1 |
January 2010 |
March 2012 |
May 2012 |
November 2, 2009 |
May 23, 2012 |
|
- Service de reanimation, Hopital Raymond Poincare
Garches, France
|
| 17 |
NCT01370200 |
Completed |
Regional Citrate Anticoagulation in Plasma Exchange Treatment |
- Focal Segmental Glomerulosclerosis
- Guillain-Barre Syndrome
|
- Procedure: plasma exchange treatment
|
Interventional |
Not Applicable |
- University Medical Centre Ljubljana
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The efficacy of plasma exchange, measuring immunoglobulins type G before and after the procedure, using 4% and 15% citrate as anticoagulants
- The percentage of patients in whom there is a 50% reduction of immunoglobulins after plasma exchange using 4% and 15% citrate as anticoagulants
- Using 15% citrate as an anticoagulant during plasma exchange treatment is as safe as using 4% citrate as anticoagulant during plasma exchange treatment.
|
140 |
All |
18 Years and older (Adult, Senior) |
NCT01370200 |
111/09/09 |
|
April 2011 |
December 2014 |
December 2014 |
June 9, 2011 |
May 27, 2015 |
|
- Center for acute and complicated dialysis, Clinical department of nephrology, UMC Ljubljana
Ljubljana, Slovenia
|
| 18 |
NCT01655394 |
Unknown † |
Change of Nerve Conduction Properties in IVIg Dependent Neuropathies |
- Guillain-Barre Syndrome
- CIDP
- Multifocal Motor Neuropathy
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT01655394 |
01607831337 |
|
October 2012 |
December 2014 |
June 2016 |
August 1, 2012 |
December 12, 2014 |
|
- University of Cologne
Cologne, Germany
|
| 19 |
NCT03268304 |
Not yet recruiting |
Feasibility of Two New Software Modules for the Rehabilitation of Patients With Neuromuscular Upper Limb Impairments |
- Stroke
- Parkinson Disease
- Traumatic Brain Injury
- Guillain-Barre Syndrome
|
- Other: VR-based training including AO and MI
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- cARAT
- dARAT
- SUS
- (and 4 more...)
|
75 |
All |
18 Years and older (Adult, Senior) |
NCT03268304 |
KAYO |
|
November 2017 |
June 2018 |
August 2018 |
August 31, 2017 |
September 26, 2017 |
|
|
| 20 |
NCT02722070 |
Not yet recruiting |
Processing Integration in Neurological Patients Using fMRI |
- Acute Inflammatory Demyelinating Polyradiculoneuropathy
- Stroke
- Anosognosia
- (and 2 more...)
|
- Device: 3 Tesla Siemens Skyra MRI scanner
|
Observational |
|
- Hadassah Medical Organization
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD) signal
|
150 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02722070 |
0657-15-HMO-CTIL |
|
March 2016 |
March 2020 |
March 2025 |
March 29, 2016 |
March 29, 2016 |
|
|
| 21 |
NCT02493725 |
Completed |
JET-GBS - Japanese Eculizumab Trial for GBS |
|
- Drug: Eculizumab
- Drug: Placebo
|
Interventional |
Phase 2 |
- Chiba University
- Japan Agency for Medical Research and Development
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- [Safety] Expressed frequency and severity of incidence of AE/SAEs after treatment with investigational product.
- [Efficacy] Proportion of subjects who reach a score of FG2 or lower on the Hughes functional grading scale at week 4（Response Rate）
- Proportion of subjects with improvement of one or more scores on the functional grading scale at each visit
- (and 15 more...)
|
34 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02493725 |
100069 |
|
July 2015 |
May 2016 |
October 2016 |
July 9, 2015 |
October 11, 2017 |
|
- Nagoya University Hospital
Nagoya, Aichi, Japan - Hokkaido University Hospital
Sapporo, Hokkaido, Japan - Kobe City Medical Center General Hospital
Kobe, Hyogo, Japan - (and 10 more...)
|
| 22 |
NCT01469858 |
Unknown † |
Perception and Multisensory Integration in Neurological Patients Using fMRI |
- Acute Inflammatory Demyelinating Polyradiculoneuropathy
- Myasthenia Gravis
- Stroke
- (and 2 more...)
|
- Device: Siemens magnetom avanto1.5 Tesla, Siemens magnetom trio A Tim system 3 Tesla
|
Interventional |
Not Applicable |
- Hadassah Medical Organization
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- assessing hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD)signal
|
30 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01469858 |
044811HMO |
|
November 2011 |
November 2013 |
November 2015 |
November 10, 2011 |
November 10, 2011 |
|
- Hadassah Medical Organization
Jerusalem, Israel
|
| 23 |
NCT03206541 |
Recruiting |
Neurologic Manifestations of the Arbovirus Infection in Colombia |
- Encephalitis
- Myelitis
- Guillain-Barre Syndrome
- (and 5 more...)
|
|
Observational |
|
- Johns Hopkins University
- Universidad del Valle, Colombia
- ZikaPLAN
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Neurological outcomes in arbovirus infections
- Viral genotype
- Immune response
|
150 |
All |
8 Years and older (Child, Adult, Senior) |
NCT03206541 |
IRB00093149 |
|
January 1, 2016 |
December 2018 |
December 2018 |
July 2, 2017 |
July 2, 2017 |
|
- Clinica Leon XIII
Medellín, Antioquia, Colombia - Neuroclinica
Medellín, Antioquia, Colombia - Clinica La Misericordia Internacional
Barranquilla, Atlantico, Colombia - (and 5 more...)
|
| 24 |
NCT00271791 |
Completed |
Prednisone Treatment for Vestibular Neuronitis |
- Vestibular Diseases
- Vestibular Neuronitis
|
|
Interventional |
Phase 2 |
- Carmel Medical Center
- Clalit Health Services, Haifa and West Galilee
- Hillel Yaffe Medical Center
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Clinical: The presence of static and dynamic nystagmus, positional and positioning nystagmus, and disequilibrium on bedside examination.
- Functional: Scores on the Dizziness Handicap Inventory questionnaires.
- Laboratory: Caloric lateralization and directional preponderance on electro-oculography (EOG).
|
17 |
All |
18 Years and older (Adult, Senior) |
NCT00271791 |
42352
20050277 |
|
September 2005 |
|
May 2007 |
January 4, 2006 |
November 6, 2007 |
|
- Unit of Otolaryngology Head and Neck Surgery, Hillel Yaffe Medical Center
Hadera, Israel - Department of Otolaryngology Head and Neck Surgery, Rambam Medical Center
Haifa, Israel - Department of Otolaryngology Head and Neck Surgery, Carmel Medical Center
Haifa, Israel - Otoneurolgy Unit, Lin Medical Center, Clalit Health Services
Haifa, Israel
|
| 25 |
NCT00411216 |
Completed
Has Results |
Recovery of Visual Acuity in People With Vestibular Deficits |
- Vestibular Neuronitis
- Vestibular Neuronitis, Bilateral
- Vestibular Schwannoma
|
- Other: Control exercises
- Other: gaze stabilization exercises
|
Interventional |
Not Applicable |
- Emory University
- National Institute on Deafness and Other Communication Disorders (NIDCD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change in Visual Acuity During Head Movement From Baseline to Discharge
- Subjective Complaints: (All Pre- and Post-intervention):
- Disability Scale
- (and 5 more...)
|
23 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00411216 |
IRB00000336
R01DC003196 |
|
August 2000 |
December 2004 |
December 2004 |
December 13, 2006 |
August 7, 2015 |
July 21, 2014 |
- Center for Rehabilitation Medicine, Emory University
Atlanta, Georgia, United States
|
| 26 |
NCT02422875 |
Enrolling by invitation |
Comparative Autoantibody and Immunologic Cell Marker Study |
- Autoimmune Diseases
- Lupus Erythematosus, Systemic
- Communicable Diseases
|
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Distribution of autoreactive B cells within bone marrow
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02422875 |
IRB00058515 |
|
August 2012 |
June 2020 |
June 2020 |
April 21, 2015 |
August 2, 2017 |
|
- Emory University Hospital (CIN/ACTSI)
Atlanta, Georgia, United States - Emory University Winship Cancer Institute
Atlanta, Georgia, United States
|
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