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129 studies found for:    "Familial hypercholesterolemia"
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Rank Status Study
21 Recruiting A Gene Therapy Study for Homozygous Familial Hypercholesterolemia (HoFH)
Condition: Homozygous Familial Hypercholesterolemia
Intervention: Biological: AAV directed hLDLR gene therapy
22 Recruiting A Study of ALN-PCSSC in Participants With Homozygous Familial Hypercholesterolemia
Condition: Homozygous Familial Hypercholesterolemia
Interventions: Drug: ALN-PCSSC;   Drug: Standard of Care
23 Recruiting Study of MGL-3196 in Patients With Heterozygous Familial Hypercholesterolemia (HeFH)
Condition: Heterozygous Familial Hypercholesterolemia
Interventions: Drug: MGL-3196;   Drug: Placebo
24 Completed Comparisons of Two Low-density Lipoprotein Apheresis Systems in Patients With Homozygous Familial Hypercholesterolemia
Condition: Homozygous Familial Hypercholesterolemia
Interventions: Device: heparin-induced extracorporeal LDL precipitation;   Device: dextran sulfate adsorption
25 Active, not recruiting Study of REGN1500 in Patients With Homozygous Familial Hypercholesterolemia (HoFH)
Condition: Homozygous Familial Hypercholesterolemia
Intervention: Drug: REGN1500
26 Completed
Has Results
A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH)
Condition: Homozygous Familial Hypercholesterolemia
Intervention: Drug: AEGR-733
27 Withdrawn Evaluate the Efficacy and Safety of Lomitapide in Pediatric Patients With Homozygous Familial Hypercholesterolemia on Stable Lipid-lowering Therapy
Condition: Homozygous Familial Hypercholesterolemia
Intervention: Drug: Lomitapide
28 Completed Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis Therapy
Condition: Heterozygous Familial Hypercholesterolemia
Interventions: Drug: Alirocumab;   Drug: Placebo
29 Completed
Has Results
Study of Alirocumab (REGN727/SAR236553) in Patients With heFH (Heterozygous Familial Hypercholesterolemia) Who Are Not Adequately Controlled With Their LMT (Lipid-Modifying Therapy)
Condition: Heterozygous Familial Hypercholesterolemia
Interventions: Drug: LMT (atorvastatin, simvastatin, or rosuvastatin);   Drug: alirocumab;   Drug: Placebo
30 Recruiting Familial Hypercholesterolemia Canada / Hypercholesterolemie Familiale Canada
Conditions: Familial Hypercholesterolemia;   Lipid Disorder
Intervention:
31 Recruiting Familial Hypercholesterolemia in Turkey (A-HIT2)
Conditions: Familial Hypercholesterolemia;   Atherosclerosis
Intervention:
32 Completed Efficacy and Safety of Fluvastatin in Children With Heterozygous Familial Hypercholesterolemia
Conditions: Heterozygous Familial Hypercholesterolemia;   Mixed Dyslipidemia
Intervention: Drug: Fluvastatin
33 Completed
Has Results
A Study to Evaluate the Efficacy and Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial Hypercholesterolemia
Condition: Homozygous Familial Hypercholesterolemia (HoFH)
Interventions: Drug: Rosuvastatin 20mg;   Drug: Placebo
34 Completed A Study to Evaluate the Safety of Rosuvastatin in Children and Adolescents With Homozygous Familial Hypercholesterolemia
Condition: Homozygous Familial Hypercholesterolemia (HoFH)
Intervention: Drug: Rosuvastatin 20mg
35 Completed A Study of the Safety and Efficacy of Anacetrapib (MK-0859) When Added to Ongoing Statin Therapy in Japanese Participants With Heterozygous Familial Hypercholesterolemia (MK-0859-050)
Condition: Heterozygous Familial Hypercholesterolemia (HeFH)
Interventions: Drug: Anacetrapib;   Drug: Placebo for anacetrapib
36 Unknown  Postprandial Lipid Metabolism in Familial Hypercholesterolaemia:Effects of Fish Oils
Conditions: Hypertriglyceridaemia;   Familial Hypercholesterolaemia
Interventions: Dietary Supplement: Fish oil capsule;   Drug: HMG Coenzyme reductase
37 Completed
Has Results
PLUTO: Pediatric Lipid-redUction Trial of rOsuvastatin
Condition: Familial Hypercholesterolemia
Interventions: Drug: Rosuvastatin;   Drug: Placebo
38 Completed
Has Results
Atorvastatin Three Year Pediatric Study
Condition: Familial Hypercholesterolemia
Intervention: Drug: atorvastatin
39 Completed Phase I Study of Ex Vivo Liver-Directed Gene Therapy for Familial Hypercholesterolemia
Condition: Familial Hypercholesterolemia
Intervention: Procedure: gene therapy
40 Completed
Has Results
Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities
Condition: Homozygous Familial Hypercholesterolemia
Interventions: Biological: Evolocumab;   Drug: Placebo

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Study has passed its completion date and status has not been verified in more than two years.