1 |
NCT02915718 |
Recruiting |
A Clinical Study of Immunoadsorption Therapy for Dilated Cardiomyopathy |
|
- Procedure: protein A immunoadsorption
|
Interventional |
Not Applicable |
- Wuhan Union Hospital, China
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Left ventricular ejection fraction (LVEF) at rest
- LVEF at rest
- Reduction of brain natriuretic peptides (BNP) or N-terminal pro-Brain Natriuretic Peptide(NT pro-BNP)
|
40 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02915718 |
XCheng |
|
October 2016 |
February 2017 |
February 2018 |
September 27, 2016 |
October 11, 2016 |
|
- Union Hospital
Wuhan, Hubei, China
|
2 |
NCT03235063 |
Recruiting |
Pregnancy and Dilated Cardiomyopathy |
|
- Other: routinely care- no intervention
|
Observational |
|
- Nantes University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- evaluate clinical characteristics
- study maternal
- neonatal evolution
- (and 9 more...)
|
100 |
Female |
18 Years and older (Adult, Senior) |
NCT03235063 |
Prog 10/17 |
|
January 2, 2013 |
January 2, 2018 |
June 1, 2018 |
August 1, 2017 |
August 24, 2017 |
|
- Chu Angers
Angers, France - Chru de Brest
Brest, France - Hospital Henri Mondor
Créteil, France - (and 12 more...)
|
3 |
NCT01917149 |
Completed |
Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy |
|
- Drug: Benazepril
- Drug: Valsartan
- Drug: Metoprolol
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- All cause death or admission for heart failure
- Changes in NYHA functional class
- Left-ventricular ejection fraction
- Left-ventricular end-diastolic diameter
|
480 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01917149 |
SIRAAS-DC |
|
March 2005 |
July 2013 |
December 2013 |
August 6, 2013 |
May 19, 2014 |
|
- Xijing Hospital, Department of Cardiology
Xi'an, China
|
4 |
NCT02115581 |
Completed Has Results |
Coenzyme Q10 Supplementation in Children With Idiopathic Dilated Cardiomyopathy |
|
- Drug: Coenzyme Q10
- Drug: Placebo
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement in Left Ventricular Ejection Fraction
- Improvement in Left Ventricular Filling Abnormality
- Adverse Events
|
38 |
All |
6 Months to 18 Years (Child, Adult) |
NCT02115581 |
CoenzymeQ10 and Cardiomyopathy |
|
September 2006 |
March 2008 |
March 2008 |
April 16, 2014 |
April 16, 2014 |
April 16, 2014 |
- Children's Medical Center
Tehran, Iran, Islamic Republic of
|
5 |
NCT00466713 |
Terminated |
Defining the Role of Insulin Resistance in 'Idiopathic' Dilated Cardiomyopathy |
|
- Drug: Rosiglitazone therapy
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Myocardial glucose uptake (intrasubject before/after rosiglitazone)
- Myocardial glucose uptake (between insulin-resistant & insulin-sensitive groups)
- Coronary flow-reserve
- 6-minute walk time
|
|
All |
18 Years and older (Adult, Senior) |
NCT00466713 |
5367 |
|
March 2007 |
December 2007 |
December 2007 |
April 27, 2007 |
May 13, 2014 |
|
- Stanford University Hospital
Stanford, California, United States
|
6 |
NCT00709163 |
Completed |
Nesiritide - Dilated Cardiomyopathy |
|
- Drug: Nesiritide
- Drug: 5% Dextrose
|
Interventional |
Not Applicable |
- University of California, Los Angeles
- Scios, Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
20 |
All |
up to 21 Years (Child, Adult) |
NCT00709163 |
A026 |
|
December 2003 |
November 2005 |
November 2005 |
July 3, 2008 |
July 3, 2008 |
|
- Mattel Children's Hospital at UCLA
Los Angeles, California, United States
|
7 |
NCT02001961 |
Unknown † |
Pathophysiology of Dilated Cardiomyopathy |
|
|
Observational |
|
- Great Ormond Street Hospital for Children NHS Foundation Trust
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Fibrosis
- Biomarkers
- Disease Severity
|
20 |
All |
up to 16 Years (Child) |
NCT02001961 |
12CC23 |
|
January 2014 |
June 2014 |
|
December 5, 2013 |
December 5, 2013 |
|
- Great Ormond Street Hospital NHS Trust
London, United Kingdom
|
8 |
NCT01020968 |
Completed |
Use of Ixmyelocel-T (Formerly Catheter-based Cardiac Repair Cell [CRC]) Treatment in Patients With Heart Failure Due to Dilated Cardiomyopathy |
|
- Biological: Ixmyelocel-T
- Other: Standard of Care
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of major adverse cardiac event (MACE) (MACE defined as: cardiac death, cardiac arrest, myocardial infarction, sustained ventricular arrhythmias, pulmonary edema, acute heart failure, unstable angina and major bleeding)
- Left ventricular ejection fraction (LVEF) (As determined by Echo, Cardiac CT and SPECT)
- Change in LV and RV dimensions and in LV volumes (As determined by Echo, Cardiac CT and SPECT)
- (and 10 more...)
|
22 |
All |
18 Years to 86 Years (Adult, Senior) |
NCT01020968 |
ABI-55-0811-1 |
|
December 2009 |
January 2013 |
December 2013 |
November 26, 2009 |
June 6, 2017 |
|
- Minneapolis Heart Institute
Minneapolis, Minnesota, United States - University Hospitals, Case Western Reserve University
Cleveland, Ohio, United States - University of Utah
Salt Lake City, Utah, United States
|
9 |
NCT00765518 |
Completed |
Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM) |
|
- Biological: Ixmyelocel-T
- Other: Standard of Care
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Safety will be assessed by: post-procedure assessments, physical exam, vital signs, laboratory tests, and adverse events including MACE (Major Adverse Cardiac Event) occurrences.
- Efficacy will be assessed by: MACE, myocardial size, function and perfusion; exercise tolerance, pulmonary function, medication usage, functional status, quality of life, surgical interventions, and blood markers for heart failure
|
40 |
All |
18 Years to 86 Years (Adult, Senior) |
NCT00765518 |
ABI-55-0712-1 |
|
September 2008 |
February 2011 |
February 2012 |
October 3, 2008 |
July 1, 2016 |
|
- Emory University Hospital Midtown
Atlanta, Georgia, United States - Cleveland Clinic Heart and Vascular Institute
Cleveland, Ohio, United States - Baylor University Medical Center
Dallas, Texas, United States - (and 2 more...)
|
10 |
NCT03207230 |
Not yet recruiting |
Multicenter Exploratory Study of Accelerometry in Dilated Cardiomyopathy |
|
- Device: Cardea SOLO
- Device: ActiGraph wGT3X-BT
- Device: Wavelet Wristband
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- VO2max correlation with daily physical activity
- NYHA correlation with daily step count
- KCCQ correlation with daily step count
|
50 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03207230 |
41695 |
MESA-DCM |
August 2017 |
March 2018 |
March 2018 |
July 2, 2017 |
August 10, 2017 |
|
|
11 |
NCT03129568 |
Recruiting |
Transcoronary Infusion of Cardiac Progenitor Cells in Pediatric Dilated Cardiomyopathy |
|
|
Interventional |
Phase 1 |
- Okayama University
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of Participants with Major Cardiac Adverse Events Related to Transcoronary Infusion of CDCs.
- Change in Ejection Fraction
|
31 |
All |
up to 17 Years (Child) |
NCT03129568 |
01F1701003 |
TICAP-DCM |
April 14, 2017 |
March 31, 2022 |
March 31, 2023 |
April 26, 2017 |
April 26, 2017 |
|
- Okayama University Hospital
Okayama, Japan
|
12 |
NCT00558584 |
Recruiting |
Multicenter Study of Immunoadsorption in Dilated Cardiomyopathy |
|
- Device: protein A immunoadsorption
- Device: pseudo-immunoadsorption
|
Interventional |
Not Applicable |
- University Medicine Greifswald
- Krupp von Bohlen und Halbach-Foundation, Essen, Germany
- ENDI-Foundation, Bad Homburg, Germany
- Bristol-Myers Squibb
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Left ventricular ejection fraction (LVEF) at rest, as determined by contrast echocardiography
- Clinical outcome (non-cardiovascular death, cardiovascular death, sudden death, hospitalization for cardiovascular cause/heart failure, acute myocardial infarction, unstable angina, stroke, cardiac interventions/procedures, clinical deterioration)
- LVEF at rest, as determined by contrast echocardiography
- (and 5 more...)
|
200 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT00558584 |
IA-2006-001 |
|
December 2007 |
December 2017 |
December 2019 |
November 15, 2007 |
May 12, 2017 |
|
- Deutsches Herzzentrum München
München, Bayern, Germany - Medizinische Klinik und Poliklinik I (Campus Großhadern u. Campus Innenstadt)
München, Bayern, Germany - Zentralklinik Bad Berka GmbH, Klinik für Kardiologie
Bad Berka, Germany - (and 19 more...)
|
13 |
NCT00629018 |
Completed Has Results |
Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy |
|
- Biological: CD34+ autologous stem cell transplantation
- Drug: Bone Marrow Stimulation
- Biological: SC therapy
|
Interventional |
Phase 2 |
- University Medical Centre Ljubljana
- Blood Transfusion Centre of Slovenia
- Stanford University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Heart Failure Mortality
- Changes in Left Ventricular Ejection Fraction
- Changes in Exercise Capacity
- (and 3 more...)
|
110 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00629018 |
DCM-SCT1 |
|
May 2006 |
April 2013 |
April 2013 |
March 5, 2008 |
May 12, 2015 |
May 12, 2015 |
- Ljubljana University Medical Center
Ljubljana, Slovenia
|
14 |
NCT01219452 |
Unknown † |
Intramuscular Injection of Mesenchymal Stem Cell for Treatment of Children With Idiopathic Dilated Cardiomyopathy |
|
- Biological: umbilical cord mesenchymal stem cells
|
Interventional |
Phase 1 Phase 2 |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- echocardiography
- 24h HOLTER
- The level of serum BNP,TNI,HGF、LIF and G/M-CSF
- The expression level of c-kit,CD31,CD133 on peripheral blood mononuclear cells
|
30 |
All |
1 Year to 14 Years (Child) |
NCT01219452 |
MSCKX002 |
|
October 2010 |
November 2012 |
December 2012 |
October 13, 2010 |
October 28, 2010 |
|
- Stem Cell Research Center of Medical School Hospital of Qingdao University
Qingdao, Shandong, China
|
15 |
NCT02148926 |
Recruiting |
Clinical and Genetic Examinations of Dilated Cardiomyopathy |
|
|
Observational |
|
- University of Southern Denmark
- Odense University Hospital
- Aarhus University Hospital
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
- Genetics
- Global longitudinal strain
|
554 |
All |
up to 100 Years (Child, Adult, Senior) |
NCT02148926 |
DCM-011213-28037 |
|
February 2014 |
May 2018 |
June 2018 |
May 29, 2014 |
March 13, 2018 |
|
- Odense University Hospital
Odense, Denmark
|
16 |
NCT00333827 |
Completed |
Cell Therapy In Dilated Cardiomyopathy |
|
- Drug: optimal therapy for cardiaca failure
- Procedure: cell
|
Interventional |
Phase 3 |
- Ministry of Health, Brazil
- Financiadora de Estudos e Projetos
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- increase of the ejection fraction of the left ventricle
- Death by any cause
- Maximum oxygen consumption difference, as measured by ergoespirometry, at six and twelve months in relation to baseline
- (and 3 more...)
|
115 |
All |
18 Years to 65 Years (Adult) |
NCT00333827 |
EMRTCC-MCD |
|
January 2006 |
December 2012 |
February 2013 |
June 6, 2006 |
March 13, 2017 |
|
- INCL - National Institute of Cardiology Laranjeiras
Rio de Janeiro, Brazil
|
17 |
NCT01583114 |
Terminated |
PREclinical Mutation CARriers From Families With DIlated Cardiomyopathy and ACE Inhibitors |
|
- Drug: perindopril
- Drug: placebo
|
Interventional |
Phase 3 |
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in left ventricle diameter / volume / ejection fraction
- Echocardiographic deterioration of LVEDD or Ejection fraction
- MRI - deterioration of LVEDVol or Ejection fraction
- (and 5 more...)
|
6 |
All |
18 Years to 60 Years (Adult) |
NCT01583114 |
C10-44 2010-023184-18 |
PRECARDIA |
December 2011 |
January 2014 |
January 2014 |
April 23, 2012 |
February 24, 2016 |
|
- Skejby University Hospital SUH, Aarhus Universit Hospital
Aarhus, Denmark - Pitié Salpêtrière Hospital
Paris, France - University of Heidelberg UKLHD
Heidelberg, Germany - (and 4 more...)
|
18 |
NCT02133911 |
Unknown † |
A Pilot Trial of Ranolazine to Treat Patients With Dilated Cardiomyopathy |
|
|
Interventional |
Phase 2 |
- University Medical Centre Ljubljana
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Myocardial perfusion
- Excercise capacity
- Left ventricular systolic and diastolic function
- Supraventricular and ventricular arrhythmias
|
70 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02133911 |
AHFTX-UMCLJ-1 |
RAMP-DCM |
May 2014 |
December 2015 |
May 2016 |
May 8, 2014 |
May 8, 2014 |
|
- Advanced Heart Failure and Transplantation Programme, University Medical Center Ljubljana, Slovenia
Ljubljana, Slovenia
|
19 |
NCT02987322 |
Completed |
Honey in Idiopathic Dilated Cardiomyopathy |
- Idiopathic Dilated Cardiomyopathy
|
- Dietary Supplement: honey
|
Interventional |
Phase 2 Phase 3 |
- mamdouh abdulmaksoud abdulrhman
- Ain Shams University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ejection fraction % as measured by echocardiography
|
50 |
All |
2 Years to 12 Years (Child) |
NCT02987322 |
4472/28.9.2015 |
|
November 2015 |
May 2016 |
November 2016 |
December 8, 2016 |
December 12, 2016 |
|
|
20 |
NCT01302171 |
Completed |
Bone Marrow Derived Adult Stem Cells for Dilated Cardiomyopathy |
|
- Drug: granulocyte colony stimulating factor (GCSF)
- Procedure: bone marrow mononuclear cells
|
Interventional |
Phase 2 |
- Barts & The London NHS Trust
- Royal Brompton & Harefield NHS Foundation Trust
- University College London Hospitals
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in left ventricular ejection fraction as measured by cardiac magnetic resonance imaging or computerised tomography
- Change in: Concentrations of N-terminal prohormone of brain natriuretic peptide (cardiac enzyme)
- Changes in V02 max (exercise capacity)
- (and 5 more...)
|
60 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01302171 |
2009-013112-12 |
REGEN-DCM |
August 2010 |
December 2012 |
July 2013 |
February 24, 2011 |
November 15, 2013 |
|
- London Chest Hospital
London, United Kingdom
|
21 |
NCT01720888 |
Unknown † |
Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy |
- Ischemic Dilated Cardiomyopathy
|
|
Interventional |
Phase 2 |
- National University of Malaysia
- Cytopeutics Sdn Bhd
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in LV ejection fraction as measured by echocardiogram and cardiac MRI after implantation
- Changes in functional status
- Improvement in other LV parameters as assessed by echocardiogram and cardiovascular magnetic resonance(CMR).
- (and 3 more...)
|
80 |
All |
35 Years to 75 Years (Adult, Senior) |
NCT01720888 |
ERGS/1/2011/SKK/UKM/02/72 |
|
July 2012 |
December 2015 |
December 2015 |
November 2, 2012 |
April 16, 2015 |
|
- UKM Medical Centre
Cheras, Kuala Lumpur, Malaysia
|
22 |
NCT03214757 |
Not yet recruiting |
A Study of Impact of Anemia on Morbidity and Mortality in Children With Dilated Cardiomyopathy |
- Pediatric Dilated Cardiomyopathy
|
- Other: treatment of anemia.
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
40 |
All |
2 Months to 18 Years (Child, Adult) |
NCT03214757 |
NA_0000XXX |
|
February 2018 |
August 2018 |
December 2018 |
July 12, 2017 |
January 10, 2018 |
|
|
23 |
NCT00629096 |
Completed |
Intracoronary Infusion of Autologous Bone Marrow Cells for Treatment of Idiopathic Dilated Cardiomyopathy |
|
- Procedure: Intracoronary infusion of autologous bone marrow cells
|
Interventional |
Phase 2 |
- Fundación Pública Andaluza Progreso y Salud
- Iniciativa Andaluza en Terapias Avanzadas
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement of left ventricular function
- Functional status
|
27 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00629096 |
TCMR0007/2006 EudraCT 2007-003088-36 |
|
February 2008 |
August 2010 |
December 2010 |
March 5, 2008 |
December 5, 2014 |
|
- Reina Sofía University Hospital
Córdoba, Spain
|
24 |
NCT00743639 |
Completed |
Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells for Dilated Cardiomyopathy |
|
- Procedure: intramyocardial bone marrow stem cells implantation
|
Interventional |
Phase 2 Phase 3 |
- Instituto de Cardiologia do Rio Grande do Sul
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Increase of the ejection function of the left ventricle
|
30 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT00743639 |
UP3758 |
SDILCM |
July 2005 |
June 2006 |
June 2008 |
August 29, 2008 |
August 29, 2008 |
|
- Institute of Cardiology of Rio Grande do Sul / FUC
Porto Alegre, Rio Grande do Sul, Brazil
|
25 |
NCT01392625 |
Completed Has Results |
PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study) |
- Non-ischemic Dilated Cardiomyopathy
|
- Biological: Autologous hMSCs
- Biological: Allogeneic hMSCs
|
Interventional |
Phase 1 Phase 2 |
- Joshua M Hare
- National Heart, Lung, and Blood Institute (NHLBI)
- University of Miami
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Incidence of Any Treatment-emergent Serious Adverse Events (TE-SAEs)
- Measurement of Changes in Peak VO2
- Measurement of Changes in 6 Minute Walk
- (and 3 more...)
|
37 |
All |
18 Years to 95 Years (Adult, Senior) |
NCT01392625 |
20100968 1R01HL110737-01 |
PoseidonDCM |
May 19, 2011 |
August 28, 2016 |
August 28, 2017 |
July 12, 2011 |
February 15, 2018 |
February 15, 2018 |
- University of Miami School of Medicine
Miami, Florida, United States
|
26 |
NCT02033278 |
Recruiting |
Infusion Intracoronary of Mononuclear Autologous Adult no Expanded Stem Cells of Bone Marrow on Functional Recovery in Patients With Idiopathic Dilated Cardiomyopathy and Heart Failure. |
- Idiopathic Dilated Cardiomyopathy
|
- Drug: Infusion of autologous mononuclear bone marrow cells
- Drug: Placebo infusion
|
Interventional |
Phase 2 |
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
- Iniciativa Andaluza en Terapias Avanzadas
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in ventricular function measured angiographically.
- Degree of clinical improvement based on the absence of major cardiac events (MACE) during follow-up.
- Clinical and analytical progress (NYHA grade & BNP)
- (and 3 more...)
|
51 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02033278 |
CMMo/MD/2013 |
|
January 6, 2014 |
February 2022 |
February 2022 |
January 10, 2014 |
March 27, 2018 |
|
- Hospital Universitario Puerta del Mar
Cádiz, Spain - Hopistal Universitario Reina Sofía
Córdoba, Spain - Hospital Universitario Virgen de las Nieves
Granada, Spain - (and 6 more...)
|
27 |
NCT01957826 |
Recruiting |
Mesenchymal Stem Cells for Idiopathic Dilated Cardiomyopathy |
- Primary Idiopathic Dilated Cardiomyopathy
|
- Other: bone marrow-derived MSCs injection
- Other: placebo intervention
|
Interventional |
Phase 1 Phase 2 |
- Hospital General Universitario Gregorio Marañon
- Ministerio de Sanidad, Servicios Sociales e Igualdad
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Major adverse cardiac adverse events. SAEs and AEs.
- NYHA functional class.
- Incidence of complications with the use of NOGA XPTM catheters.
- (and 7 more...)
|
70 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01957826 |
FIBHGM-ECNC017-2010 2010-024406-35 MIYOCYTE |
|
March 2013 |
March 2018 |
March 2018 |
October 8, 2013 |
November 18, 2016 |
|
- Hospital General Universitario Gregorio Marañón
Madrid, Spain - Hospital Clinico Universitario de Valladolid
Valladolid, Spain
|
28 |
NCT01670981 |
Active, not recruiting |
An Efficacy, Safety and Tolerability Study of Ixmyelocel-T Administered Via Transendocardial Catheter-based Injections to Subjects With Heart Failure Due to Ischemic Dilated Cardiomyopathy (IDCM) |
- Ischemic Dilated Cardiomyopathy (IDCM)
|
- Biological: ixmyelocel-T
- Other: Placebo
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Average number of clinical events over 12 months post-treatment.
- The win ratio of the hierarchical occurrence of all-cause deaths/left ventricular assist device (LVAD) implant/heart transplant, cardiovascular hospitalizations, and unplanned outpatient and ED interventions to treat ADHF
- Change from baseline to 12 months post-treatment in 6-minute walk test.
- (and 5 more...)
|
114 |
All |
30 Years to 86 Years (Adult, Senior) |
NCT01670981 |
ABI 55-1202-1 |
ixCELL DCM |
October 2012 |
February 2016 |
November 2018 |
August 23, 2012 |
March 8, 2017 |
|
- Cardiology, P.C. & Center for Therapeutic Angiogenesis
Birmingham, Alabama, United States - University of Alabama at Birmingham
Birmingham, Alabama, United States - Mercy Gilbert Medical Center
Gilbert, Arizona, United States - (and 33 more...)
|
29 |
NCT01350310 |
Completed |
Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy |
- Dilated Cardiomyopathy
- Chronic Heart Failure
|
- Procedure: Intramyocardial injection
- Procedure: Intracoronary injection
|
Interventional |
Phase 2 |
- University Medical Centre Ljubljana
- The Methodist Hospital System
- Stanford University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in left ventricular ejection fraction and dimensions
- Changes in exercise capacity
- Change in NT-proBNP levels
|
110 |
All |
18 Years to 65 Years (Adult) |
NCT01350310 |
NOGA-DCM |
NOGA-DCM |
March 2011 |
August 2014 |
December 2014 |
May 9, 2011 |
April 7, 2015 |
|
- UMC Ljubljana
Ljubljana, Slovenia
|
30 |
NCT03439514 |
Recruiting |
A Study of ARRY-371797 in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation |
- Dilated Cardiomyopathy
- Lamin A/C Gene Mutation
|
- Drug: ARRY-371797
- Other: Placebo
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in 6-minute walk test (6MWT)
- Change from baseline in Kansas City Cardiomyopathy Questionnaire (KCCQ) Physical Limitation (PL) domain
- Change from baseline in Kansas City Cardiomyopathy Questionnaire (KCCQ) as measured by Total Symptom Score (TSS) domain
- (and 7 more...)
|
160 |
All |
18 Years and older (Adult, Senior) |
NCT03439514 |
ARRAY-797-301 |
|
March 12, 2018 |
April 2020 |
July 2020 |
February 20, 2018 |
April 19, 2018 |
|
- University of Colorado
Aurora, Colorado, United States - Brigham and Womens Hospital
Boston, Massachusetts, United States - Ohio State University Wexner Medical Center
Columbus, Ohio, United States - Meriter Hospital
Madison, Wisconsin, United States
|
31 |
NCT02440217 |
Unknown † |
Myocardial Metabolism in Patients With Dilated Cardiomyopathy |
- Dilated Cardiomyopathy
- Type 2 Diabetes
|
|
Observational |
|
- Azienda Ospedaliero, Universitaria Pisana
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Myocardial metabolic responses to stress in humans
|
15 |
All |
21 Years to 69 Years (Adult, Senior) |
NCT02440217 |
CardMet |
|
May 2015 |
June 2015 |
June 2015 |
May 12, 2015 |
May 12, 2015 |
|
- Azienda Ospedaliero-Universitaria Pisana
Pisa, PI, Italy
|
32 |
NCT02989181 |
Recruiting |
Continues Positive Airway Pressure Treatment for Patients With Dilated Cardiomyopathy and Obstructive Sleep Apnea |
- Dilated Cardiomyopathy
- Obstructive Sleep Apnea
|
- Device: Continues Positive Airway Pressure (CPAP)
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Change in left ventricular ejection fraction (LVEF) six months after randomization to Continues Positive Airway Pressure (CPAP) treatment or consultation of conservative measures
- Change in measurements of diastolic function after randomization to Continues Positive Airway Pressure (CPAP) or consultation of conservative measures.
- Change in measurements of cardiovascular biomarkers at
- (and 2 more...)
|
44 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02989181 |
FoU127221 |
RIDA |
November 2014 |
December 2018 |
December 2019 |
December 12, 2016 |
March 8, 2018 |
|
- Sahlgrenska University Hospital/Östra
Gothenburg, Sweden
|
33 |
NCT02248532 |
Completed |
Repetitive Intramyocardial CD34+ Cell Therapy in Dilated Cardiomyopathy (REMEDIUM) |
- Dilated Cardiomyopathy
- Heart Failure
|
- Biological: Stem cell therapy
|
Interventional |
Phase 2 Phase 3 |
- University Medical Centre Ljubljana
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in left ventricular ejection fraction
- Changes in regional wall motion
- Change in left ventricular dimension
- (and 2 more...)
|
66 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02248532 |
REMEDIUM |
REMEDIUM |
January 2014 |
September 2017 |
December 2017 |
September 25, 2014 |
January 23, 2018 |
|
- UMC Ljubljana
Ljubljana, Please Select, Slovenia
|
34 |
NCT02652728 |
Unknown † |
Orodispersible Minitablets of Enalapril in Children With Heart Failure Due to Dilated Cardiomyopathy |
- Heart Failure
- Dilated Cardiomyopathy
|
- Drug: Enalapril Orodispersible Minitablet
|
Interventional |
Phase 2 Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Area under the Curve (AUC) of enalapril and its active metabolite enalaprilat after administration of enalapril ODMTs in children with heart failure
- Maximum Concentration (Cmax) of enalapril and its active metabolite enalaprilat after administration of enalapril ODMTs in children with heart failure
- Time to Maximum Concentration (Tmax) of enalapril and its active metabolite enalaprilat after administration of enalapril ODMTs in children with heart failure
- (and 18 more...)
|
50 |
All |
1 Month to 11 Years (Child) |
NCT02652728 |
2015-602295-01 2015-002335-17 |
LENA-WP08 |
January 2016 |
June 2017 |
June 2017 |
January 12, 2016 |
January 12, 2016 |
|
- Medical University of Vienna
Vienna, Austria - Hungarian Paediatric Heart Centre, Göttsegen Gyorgy Hungarian Institute of Cardiology
Budapest, Hungary - Sophia Children's Hospital, Erasmus MC
Rotterdam, Netherlands - (and 3 more...)
|
35 |
NCT01293903 |
Completed |
Study of Qiliqiangxin Capsule to Treat Dilated Cardiomyopathy |
- Dilated Cardiomyopathy
- Heart Failure
|
- Drug: Qiliqiangxin capsule
- Drug: Placebo
|
Interventional |
Phase 4 |
- Huazhong University of Science and Technology
- Fudan University
- First Affiliated Hospital of Harbin Medical University
- (and 24 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The value of left ventricular end-diastolic dimension (LVEDd) and left ventricular ejection fraction(LVEF) confirmed by ultrasonic cardiogram (UCG)
- The levels of serum representative cytokines detected by ELISA
- Heart failure aggravation
- (and 4 more...)
|
374 |
All |
14 Years to 70 Years (Child, Adult, Senior) |
NCT01293903 |
QLQX-DCM-01 |
QLQX-DCM |
January 2012 |
December 31, 2015 |
September 30, 2016 |
February 11, 2011 |
August 29, 2017 |
|
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
|
36 |
NCT00293137 |
Terminated |
NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy |
- Chronic Systolic Heart Failure (Dilated Cardiomyopathy)
|
|
Observational |
|
|
Other |
|
- Primary Endpoint • Comparison of NO-derived oxidants, systemic ADMA, skin blood flow, forearm blood flow and exhaled NO. • Correlation of NO-derived oxidants, systemic ADMA, skin blood flow, forearm blood flow and exhaled NO to functional capacity
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT00293137 |
NORDIC |
NORDIC |
February 2006 |
|
August 2007 |
February 17, 2006 |
September 19, 2008 |
|
- Cleveland Clinic
Cleveland, Ohio, United States
|
37 |
NCT01015144 |
Completed |
The Influence of Atorvastatin on the Parameters of Inflammation and the Function of Left Ventricle |
|
|
Observational |
|
- Medical Universtity of Lodz
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- left ventricular function
- mortality
|
|
All |
18 Years and older (Adult, Senior) |
NCT01015144 |
502-11-585 |
|
February 2007 |
December 2008 |
February 2009 |
November 18, 2009 |
November 18, 2009 |
|
|
38 |
NCT02078141 |
Active, not recruiting |
18F-deoxyglucose (FDG) PET-CMD |
- Patients With Idiopathic Dilated Cardiomyopathy
|
- Drug: 18F-deoxyglucose (FDG)
|
Interventional |
Not Applicable |
- Nantes University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Determine the percentage of patients with a diagnostic potential of the 18F-FDG PET in the detection of a significant non-cardiomyocyte hypermetabolism
- Comparison of clinical, biology, and left and ventricular remodeling at the time of diagnosis of DCM between the group of patients with significative myocardial no cardiomyocytaire uptake (FDG +) and those with no uptake (FDG -)
- Evaluate the performance of 18F-FDG PET for the detection of myocardial inflammation in the initial evaluation of DCM patients compared to cardiac MRI
- (and 2 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02078141 |
RC14_0002 |
|
June 2014 |
May 2018 |
|
March 5, 2014 |
March 30, 2018 |
|
- Nantes UH
Nantes, France - West Cancerology Institute/Nantes UH : PET plateform
Saint Herblain, France
|
39 |
NCT02479776 |
Completed |
A Trial of Autologous Bone Marrow Derived Stem Cells in Paediatric Heart Failure |
|
- Biological: stem cell injection
|
Interventional |
Not Applicable |
- Great Ormond Street Hospital for Children NHS Foundation Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- adverse effect
- Blood for NT pro BNP
- MRI volumes
|
10 |
|
Child, Adult, Senior |
NCT02479776 |
07CC37 |
|
May 2008 |
January 2015 |
March 2015 |
June 24, 2015 |
June 24, 2015 |
|
|
40 |
NCT02770443 |
Recruiting |
Withdrawal of Medication in Recovered DCM |
|
- Drug: withdrawal
- Drug: standard of CARE
|
Interventional |
Not Applicable |
- McGill University
- McGill University Health Center
- Jewish General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of patients that remain clinically in NYHA Class I
- Number of patients that maintain LVEF > or = 50%
- Average BNP level compared to baseline BNP level
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02770443 |
15-284-MUHC |
WrecEF |
February 2016 |
February 2018 |
July 2018 |
May 12, 2016 |
May 12, 2016 |
|
- Royal Victoria Hospital
Montreal, Quebec, Canada
|
41 |
NCT02847585 |
Recruiting |
Potential Role of Water-soluble Ubiquinol in Complementary Therapy for Pediatric Dilated Cardiomyopathy |
- Pediatric Dilated Cardiomyopathy
|
- Dietary Supplement: Water-soluble Ubiquinol
|
Interventional |
Not Applicable |
- Chung Shan Medical University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Left ventricular ejection fraction
- Levels of plasma coenzyme Q10
- B-type natriuretic peptide (BNP)
- (and 6 more...)
|
25 |
All |
1 Month to 20 Years (Child, Adult) |
NCT02847585 |
MOST105-2628-B-040-MY2 |
|
August 2016 |
July 2018 |
July 2018 |
July 28, 2016 |
February 27, 2017 |
|
- Chung Shan Medical University
Taichung, Taiwan
|
42 |
NCT03037632 |
Recruiting |
DCM Precision Medicine Study |
- Idiopathic Dilated Cardiomyopathy
|
- Behavioral: Family Heart Talk Booklet
|
Interventional |
Not Applicable |
- Ray Hershberger
- National Heart, Lung, and Blood Institute (NHLBI)
- National Human Genome Research Institute (NHGRI)
- Ohio State University
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Family clinical screening completed within 12 months from proband enrollment.
- Living first-degree relative adheres to cardiovascular surveillance recommendations after return of genetic results.
|
6500 |
All |
Child, Adult, Senior |
NCT03037632 |
2015H0309 R01HL128857 |
|
June 7, 2016 |
June 2019 |
June 2021 |
January 31, 2017 |
March 27, 2018 |
|
- University of Arizona Sarver Heart Center
Tucson, Arizona, United States - Stanford University
Palo Alto, California, United States - Medstar Washington Hospital Center (DC)
Washington, District of Columbia, United States - (and 18 more...)
|
43 |
NCT00615394 |
Completed |
Autologous Transplantation of Bone Marrow Mononuclear Stem-Cells by Mini-Thoracotomy |
|
- Procedure: intramyocardial bone marrow stem cells implantation
|
Interventional |
Phase 1 Phase 2 |
- Instituto de Cardiologia do Rio Grande do Sul
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- safety: morbidity/mortality
|
6 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT00615394 |
UP3549/04 |
STEMDILCARD |
April 2004 |
October 2006 |
December 2006 |
February 14, 2008 |
February 14, 2008 |
|
- Instituto de Cardiologia do Rio Grande do Sul
Porto Alegre, RS, Brazil
|
44 |
NCT02351856 |
Active, not recruiting |
A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy |
- LMNA-Related Dilated Cardiomyopathy
|
- Drug: ARRY-371797, p38 inhibitor, oral
|
Interventional |
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Assess the safety of study drug in terms of adverse events, clinical laboratory tests and electrocardiograms.
- Assess the efficacy of study drug in terms of change in 6-minute walk test.
- Assess the efficacy of study drug in terms of left ventricular function.
- (and 3 more...)
|
8 |
All |
18 Years and older (Adult, Senior) |
NCT02351856 |
ARRAY-797-001 |
|
February 2015 |
February 1, 2019 |
December 31, 2019 |
January 30, 2015 |
February 23, 2018 |
|
- University of Colorado
Aurora, Colorado, United States - Johns Hopkins University
Baltimore, Maryland, United States - Brigham and Women's Hospital
Boston, Massachusetts, United States - Meriter Wisconsin Heart
Madison, Wisconsin, United States
|
45 |
NCT02057341 |
Completed |
A Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy |
- LMNA-Related Dilated Cardiomyopathy
|
- Drug: ARRY-371797, p38 inhibitor; oral
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Assess the efficacy of the study drug in terms of change from Baseline in 6-minute walk test.
- Assess the efficacy of study drug in terms of left ventricular function.
- Assess the efficacy of study drug in terms of right ventricular function.
- (and 2 more...)
|
12 |
All |
18 Years and older (Adult, Senior) |
NCT02057341 |
ARRAY-797-231 |
|
February 2014 |
May 2016 |
May 2016 |
February 7, 2014 |
May 16, 2017 |
|
- Stanford University School of Medicine
Stanford, California, United States - University of Colorado School of Medicine
Aurora, Colorado, United States - Johns Hopkins University
Baltimore, Maryland, United States - (and 3 more...)
|
46 |
NCT00847964 |
Completed |
Safety and Feasibility of Algisyl-LVR™ as a Method of Left Ventricular Restoration in Patients With DCM Undergoing Open-heart Surgery |
|
|
Interventional |
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Freedom from serious adverse events
|
11 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00847964 |
SYM-08-001 |
|
February 2009 |
November 2011 |
November 2012 |
February 19, 2009 |
November 30, 2012 |
|
- Deutsche Herzzentrum München
München, Bavaria, Germany - Heart Center of the Technical University of Dresden
Dresden, Germany - John Paul II Hospital
Cracow, Poland
|
47 |
NCT00523653 |
Unknown † |
The Genetics of Dilated Cardiomyopathy: A Quebec-Based Study |
- Dilated Cardiomyopathy (DCM)
|
|
Observational |
|
- McGill University Health Center
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT00523653 |
BMB 07-004 |
|
January 2008 |
|
December 2008 |
August 31, 2007 |
March 19, 2008 |
|
- Royal Victoria Hospital
Montreal, Quebec, Canada
|
48 |
NCT00208806 |
Completed |
Resynchronization Therapy in Young Patients With and Without CHD |
- Dilated Cardiomyopathy
- Pediatric
|
- Other: congestive heart failure patients
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
50 |
All |
up to 18 Years (Child, Adult) |
NCT00208806 |
0418-2004 |
|
June 2004 |
December 2006 |
December 2006 |
September 21, 2005 |
December 10, 2013 |
|
- Children's Healthcare of Atlanta
Atlanta, Georgia, United States
|
49 |
NCT00934609 |
Completed |
Training Study to Evaluate the Benefit of Exercise for Patients With Chronic Heart Failure |
- Dilated Cardiomyopathy
- Chronic Heart Failure
|
- Behavioral: Endurance training
|
Interventional |
Not Applicable |
- Saarland University
- The German Heart Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Physical capacity
- Left ventricular function
- occurence of complications
|
66 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00934609 |
2000-01SaarlandU |
CHF |
|
|
|
July 8, 2009 |
September 18, 2009 |
|
- Institute of Sports- and Preventive Medicine, Saarland University
Saarbrücken, Saarland, Germany
|
50 |
NCT00374465 |
Unknown † |
Therapy With Verapamil or Carvedilol in Chronic Heart Failure |
|
- Drug: Verapamil
- Drug: Carvedilol
|
Interventional |
Phase 4 |
- Medical University of Silesia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single
- Primary Purpose: Treatment
|
- Sserum level of NT-proBNP,LVEF, LV diameters, exercise capacity (NYHA, V02,6 min walking test, changes in quality of life (MLHFQ).
- In addition to secondary endpoints efficacy, patients will be classified as improved if they meet an increase of > 10 percentage points in the absolute EF and decrease in NT-proBNP levels at least 50% as compared with baseline study.
- Combined: mortality, heart transplantation, and readmission to hospital due to heart failure progression
|
100 |
All |
18 Years to 65 Years (Adult) |
NCT00374465 |
CavsBe.06 |
|
January 2006 |
|
May 2008 |
September 11, 2006 |
September 11, 2006 |
|
- Silesian Centre for Heart Disease, 3rd Department of Cardiology
Zabrze, Szpitalna 2 st., Poland
|