| 1 |
NCT03053271 |
Recruiting |
A Study of ATR-101 for the Treatment of Endogenous Cushing's Syndrome |
|
- Drug: ATR-101
- Drug: Placebos
|
Interventional |
Phase 2 |
- Millendo Therapeutics, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- The proportion of subjects with either a normal 24-hr urinary free cortisol (UFC) or a reduction in 24-hr UFC of ≥ 50% relative to their baseline value
- The proportion of subjects with a normal 24-hr UFC
- The proportion of subjects with a reduction in 24-hr UFC of ≥ 50% relative to their baseline value
- (and 4 more...)
|
16 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03053271 |
ATR-101-301 |
|
February 16, 2017 |
November 2018 |
November 2018 |
February 15, 2017 |
February 1, 2018 |
|
- University of Alabama - Birmingham
Birmingham, Alabama, United States - Mayo Clinic
Rochester, Minnesota, United States - The Cleveland Clinic Foundation
Cleveland, Ohio, United States - (and 7 more...)
|
| 2 |
NCT03277690 |
Recruiting |
A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome. |
- Endogenous Cushing's Syndrome
|
- Drug: Levoketoconazole
- Drug: Placebo
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of subjects with loss of therapeutic response to levoketoconazole upon withdrawing to placebo compared with the proportion of subjects with loss of therapeutic response upon continuing treatment with levoketoconazole.
|
35 |
All |
18 Years and older (Adult, Senior) |
NCT03277690 |
COR-2017-01 |
|
September 26, 2017 |
May 30, 2018 |
July 1, 2018 |
September 11, 2017 |
February 12, 2018 |
|
- UCLA School of Medicine, Medicine/Endocrinology Dept.
Los Angeles, California, United States - Johns Hopkins University, Endocrinology Dept.
Baltimore, Maryland, United States - Allegheny Neuroendocrinology Center, West Penn Allegheny Health System
Pittsburgh, Pennsylvania, United States
|
| 3 |
NCT03343470 |
Recruiting |
The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS) |
|
|
Observational |
|
- University of Roma La Sapienza
- Federico II University
- University of Palermo
- (and 3 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- change from baseline in measurement of melatonin secretion at 3 and 6 months
- Evaluation of immunological profile at baseline, 3 and 6 months
- Evaluation of cortisol circadian rhythm
- Change from baseline in measurement of anthropometric-metabolic parameters at 3 and 6 months
|
15 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03343470 |
Adrenal_2 |
TheHOURS |
November 8, 2017 |
November 15, 2018 |
December 30, 2018 |
November 17, 2017 |
January 29, 2018 |
|
- Department of Experimental Medicine
Rome, Italy
|
| 4 |
NCT02663609 |
Enrolling by invitation |
Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome |
|
|
Observational |
|
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Drug Utilization Patterns as assessed by chart review
- Clinical Outcomes as assessed by chart review
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02663609 |
C1073-450 |
RE-KLAIM |
October 2015 |
December 2017 |
December 2017 |
January 26, 2016 |
February 15, 2017 |
|
|
| 5 |
NCT02804750 |
Recruiting |
Study to Evaluate CORT125134 in Patients With Cushing's Syndrome |
|
|
Interventional |
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- General safety of CORT125134 in patients with endogenous Cushing's syndrome.
- The evidence of reduction in cortisol activity following treatment of CORT125134 in patients with endogenous Cushing's syndrome.
|
30 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02804750 |
CORT125134-451 |
|
June 2016 |
December 2017 |
December 2017 |
June 17, 2016 |
June 19, 2017 |
|
- Aurora, Colorado, United States
- Fort Lauderdale, Florida, United States
- Miami, Florida, United States
- (and 18 more...)
|
| 6 |
NCT03379363 |
Recruiting |
Retrospective Chart Review Study of Pediatric Patients Treated With Korlym for Cushing Syndrome |
- Hypercortisolism
- Cushing Syndrome
|
|
Observational |
|
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Drug utilization patterns as assessed by chart review
- Weight as assessed by chart review
- Blood Pressure as assessed by chart review
|
10 |
All |
up to 21 Years (Child, Adult) |
NCT03379363 |
C1073-900 |
|
September 18, 2017 |
December 31, 2017 |
December 31, 2017 |
December 20, 2017 |
December 20, 2017 |
|
- Corcept Therapeutics
Menlo Park, California, United States
|
| 7 |
NCT02791698 |
Recruiting |
The Accuracy of Late Night Urinary Free Cortisol/Creatinine and Hair Cortisol in Cushing's Syndrome Diagnosis |
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Diagnosis of Cushing's syndrome
|
80 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02791698 |
0049-15-BNZ |
|
June 2016 |
May 2019 |
May 2020 |
June 7, 2016 |
October 27, 2016 |
|
- Saiegh leonard
Haifa, Israel
|
| 8 |
NCT02922257 |
Recruiting |
Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery |
|
|
Observational |
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02922257 |
FKBP5-700 |
|
November 2016 |
December 2020 |
December 2021 |
October 4, 2016 |
August 23, 2017 |
|
- Los Angeles, California, United States
- Rochester, Minnesota, United States
- Cleveland, Ohio, United States
- Seattle, Washington, United States
|
| 9 |
NCT02646553 |
Recruiting |
Saliva Cortisol Measurement as a Screening Test for Suspicious Cushings Syndrome in Children. |
|
- Other: Children refered to the obesity clinic
|
Observational |
|
- Haukeland University Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Number of patients with positive saliva cortisol measurement, not having Cushings syndrome.
- Number of patients With negative saliva cortisol measurement , having Cushings syndrome.
|
70 |
All |
4 Years to 16 Years (Child) |
NCT02646553 |
2012/842 |
|
May 2012 |
April 2019 |
April 2019 |
January 5, 2016 |
August 16, 2017 |
|
- Haukeland University Hospital
Bergen, Norway
|
| 10 |
NCT02019706 |
Recruiting |
Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Patients With Ectopic Cushing Syndrome |
|
- Drug: F-DOPA PET Scan
- Drug: Mifepristone
- Drug: Ga-DOTATATE
- (and 2 more...)
|
Interventional |
Phase 2 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Which imaging technique (TATA PET/CT, Ga-DOTATATE PET/CT, OCT, CT and MRI) has the best sensitivity?
|
80 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02019706 |
140028
14-CH-0028 |
|
November 26, 2013 |
August 15, 2018 |
August 15, 2018 |
December 24, 2013 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 11 |
NCT02297945 |
Recruiting |
Effects of Metyrapone in Patients With Endogenous Cushing's Syndrome |
|
|
Interventional |
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Normalization of cortisol levels (urinary free cortisol)
|
70 |
All |
18 Years and older (Adult, Senior) |
NCT02297945 |
HRA112025-002 |
PROMPT |
April 2015 |
June 2018 |
November 2018 |
November 21, 2014 |
February 15, 2017 |
|
- University hospital Antwerp
Antwerp, Belgium - CHU Erasme
Brussels, Belgium - University hospital Saint Luc
Brussels, Belgium - (and 26 more...)
|
| 12 |
NCT02611258 |
Recruiting |
Endocrine Cardiomyopathy in Cushing Syndrome: Response to Cyclic GMP PDE5 inhibitOrs |
- Cushing's Syndrome Cardiomyopathy
|
|
Interventional |
Phase 2 |
- Andrea M. Isidori
- University of Roma La Sapienza
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change of Left ventricular torsion (°) evaluated through Cardiac Magnetic Resonance
- Change of cardiac strain (σ - longitudinal shortening: strain %) evaluated through Cardiac Magnetic Resonance
- Quantification of Myocardial fibrosis assessed with T1-mapping through Cardiac Magnetic Resonance
- (and 10 more...)
|
18 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02611258 |
ERGO
2015-004497-15 |
ERGO |
July 2016 |
January 2019 |
June 2019 |
November 20, 2015 |
January 30, 2018 |
|
- Elisa Giannetta
Rome, Italy - Elisa Giannetta
Rome, Italy
|
| 13 |
NCT03211624 |
Recruiting |
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome |
|
|
Observational |
|
- Göteborg University
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
- Leiden University Medical Center
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Cognitive function
- Quality of life
- Brain volume
- (and 3 more...)
|
72 |
All |
18 Years to 65 Years (Adult) |
NCT03211624 |
CognCush |
|
May 1, 2017 |
December 31, 2022 |
December 31, 2023 |
July 7, 2017 |
July 7, 2017 |
|
- Dept of Medicine, Division of Endocrinology, and Center for Endocrine Tumors, Leiden University Medical Center
Leiden, Netherlands - Dept of Endocrinology, Hospital Sant Pau
Barcelona, Spain - Sahlgrenska University Hospital
Gothenburg, Sweden
|
| 14 |
NCT00936741 |
Completed
Has Results |
An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome |
|
|
Interventional |
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Participants With Adverse Events
- The Long-term Benefit of Mifepristone Treatment in Cushing's Syndrome as Measured by Changes in the Score on the Physician's Global Assessment of Disease Severity
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT00936741 |
C-1073-415 |
|
July 2009 |
September 2012 |
September 2012 |
July 10, 2009 |
April 2, 2014 |
April 2, 2014 |
- University of Alabama at Birmingham School of Medicine
Birmingham, Alabama, United States - AMCR Institute Inc.
Escondido, California, United States - Stanford University Medical Center
Stanford, California, United States - (and 12 more...)
|
| 15 |
NCT01838551 |
Active, not recruiting |
Treatment for Endogenous Cushing's Syndrome |
- Endogenous Cushing's Syndrome
|
|
Interventional |
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction in urinary free cortisol in patients with endogenous Cushing's Syndrome.
|
90 |
All |
18 Years and older (Adult, Senior) |
NCT01838551 |
COR-003 |
|
August 2014 |
April 2018 |
October 2018 |
April 24, 2013 |
February 16, 2018 |
|
- UCLA School of Medicine
Los Angeles, California, United States - Johns Hopkins University
Baltimore, Maryland, United States - Massachusetts General Hospital
Boston, Massachusetts, United States - (and 39 more...)
|
| 16 |
NCT02543697 |
Recruiting |
Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors |
|
- Radiation: Adrenal venous sampling
|
Interventional |
Not Applicable |
- Haukeland University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Lateralisation of cortisol overproduction
- Biochemically and clinically normalising after treatment
- Verify overproduction of cortisol from the adrenals
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02543697 |
2014/2170 |
AVS |
February 2015 |
February 2019 |
February 2020 |
September 7, 2015 |
September 8, 2016 |
|
- Haukeland University Hospital
Bergen, Norway
|
| 17 |
NCT00569582 |
Completed
Has Results |
A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome |
|
|
Interventional |
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement in Diabetes and/or Glucose Intolerance.
- Decrease in Diastolic Blood Pressure.
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT00569582 |
C-1073-400 |
SEISMIC |
December 2007 |
January 2011 |
|
December 7, 2007 |
August 22, 2013 |
May 28, 2012 |
- University of Alabama at Birmingham School of Medicine
Birmingham, Alabama, United States - AMCR Institute Inc.
Escondido, California, United States - Stanford University Medical Center
Stanford, California, United States - (and 14 more...)
|
| 18 |
NCT01382420 |
Recruiting |
Long-term Beneficial Metabolic Effects of Adrenalectomy in Subclinical Cushing's Syndrome of Adrenal Incidentaloma |
|
|
Interventional |
Not Applicable |
- Samsung Medical Center
- Asan Medical Center
- Severance Hospital
- Konkuk University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change of lipid profile between two groups
- Incidence of obesity between two groups
|
234 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT01382420 |
2011-03-034 |
|
May 2011 |
May 2018 |
May 2018 |
June 27, 2011 |
November 17, 2015 |
|
- Samsung Medical Center
Seoul, Korea, Republic of
|
| 19 |
NCT00029952 |
Completed |
Long Term Post Operative Follow-Up of Cushing Syndrome |
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
500 |
All |
Child, Adult, Senior |
NCT00029952 |
930169
93-CH-0169 |
|
July 1993 |
|
September 2004 |
January 28, 2002 |
March 4, 2008 |
|
- National Institute of Child Health and Human Development (NICHD)
Bethesda, Maryland, United States
|
| 20 |
NCT00422201 |
Terminated
Has Results |
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion |
|
|
Interventional |
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Glycemic Disorders Improved or Normalized
- Features of Cushing's Syndrome
|
18 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT00422201 |
070008
07-CH-0008 |
|
December 2006 |
April 2012 |
April 2012 |
January 15, 2007 |
November 11, 2013 |
October 14, 2013 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States - CHU de Bordeaux Hopital Haut Leveque
Bordeaux, France - C.H.U Albert Michallon
Grenoble, France - (and 12 more...)
|
| 21 |
NCT00796783 |
Terminated |
A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia |
|
- Drug: Cushing's syndrome confirmation
|
Observational |
|
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- To confirm the presence of recurrent or persistent endogenous Cushing's syndrome in patients who have had primary surgical and/or radiation therapy for Cushing's disease and continue to manifest symptoms and signs of hypercortisolemia.
|
2 |
All |
18 Years and older (Adult, Senior) |
NCT00796783 |
C-1073-410 |
|
February 2009 |
June 2010 |
|
November 24, 2008 |
June 20, 2014 |
|
- AMCR Institute Inc.
Escondido, California, United States - The Center for Diabetes and Endocrine Care
Hollywood, Florida, United States - Diabetes and Glandular Disease Research
San Antonio, Texas, United States
|
| 22 |
NCT00001453 |
Completed |
Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome |
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
98 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00001453 |
950104
95-CH-0104 |
|
April 10, 1995 |
|
October 20, 2014 |
November 4, 1999 |
October 6, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 23 |
NCT00001849 |
Recruiting |
New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome |
|
- Drug: Pentetreotide
- Drug: 18-F-fluorodeoxyglucose
- Drug: (18F)-L-3,4-dihydroxyophenylalanine (18F-DOPA)
|
Interventional |
Phase 1
Phase 2 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Sensitivity, specificity and diagnostic accuracy of imaging modalities for the detection of ACTH-secreting non-pituitary tumor
|
202 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT00001849 |
990055
99-CH-0055 |
|
February 26, 1999 |
December 31, 2019 |
December 31, 2019 |
November 4, 1999 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 24 |
NCT01688349 |
Completed |
Pattern of Gene Expression in Adipose Tissue From Patients With Cushing Syndrome |
- Cushing Syndrome Related to Cortisolic Adenoma
|
- Other: analyze the role of glucocorticoid in AT distribution.
|
Interventional |
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Comparison between visceral adipose tissue of Cushing patients and that of normal weight controls.
- Comparison of the respective SCAT and VAT between Cushing patients and normal weight controls.
- Comparison of the respective SCAT and VAT between Cushing patients and obese controls.
- comparison between SCAT and VAT from Cushing patients
|
90 |
All |
18 Years and older (Adult, Senior) |
NCT01688349 |
P110906
CRC11001 |
LIPOCUSH |
October 2012 |
September 16, 2016 |
September 16, 2016 |
September 19, 2012 |
March 22, 2017 |
|
- Hôpital Saint-Antoine, service d'Endocrinologie
Paris, France
|
| 25 |
NCT03145285 |
Active, not recruiting |
Activity of Abiraterone Acetate in the Management of Cushing's Syndrome in Patients With Adrenocortical Carcinoma |
- Cushing Syndrome
- Adrenocortical Carcinoma
|
- Drug: Abiraterone Acetate
|
Interventional |
Phase 2 |
- Azienda Ospedaliera Spedali Civili di Brescia
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
- Niguarda Hospital
- (and 2 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To assess the activity of AA in attaining normalization of 24-h urinary free cortisol (UFC) excretion relative to baseline within 1 month from treatment start
- to assess the activity of AA in attaining 50% reduction of 24-h UFC excretion within 1 month of treatment
- time to reduction of UFC (compared to screening values)
- (and 8 more...)
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT03145285 |
ASSTBS-ONCO-ABACUS-16
2016-000945-29 |
ABACUS |
April 18, 2017 |
April 18, 2020 |
April 18, 2021 |
May 9, 2017 |
May 10, 2017 |
|
- U.O Oncologia Medica
Brescia, BS, Italy
|
| 26 |
NCT00004334 |
Unknown † |
Study of Depression, Peptides, and Steroids in Cushing's Syndrome |
|
|
Observational |
|
- National Center for Research Resources (NCRR)
- University of Michigan
|
NIH / Other |
- Primary Purpose: Screening
|
|
8 |
All |
20 Years to 60 Years (Adult) |
NCT00004334 |
NCRR-M01RR00042-1781
UMMC-701 |
|
July 1994 |
|
|
October 19, 1999 |
June 24, 2005 |
|
- University of Michigan Health Systems
Ann Arbor, Michigan, United States
|
| 27 |
NCT00361777 |
Active, not recruiting |
Diagnostic Performance of Screening Tests for Cushing s Syndrome |
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
471 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00361777 |
020309
02-CH-0309 |
|
September 19, 2002 |
|
|
August 9, 2006 |
April 5, 2018 |
|
- GW University Medical Center GW Hospital Center
Washington, District of Columbia, United States - National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 28 |
NCT00004326 |
Completed |
Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome |
|
|
Observational |
|
- National Center for Research Resources (NCRR)
- University of Michigan
|
NIH / Other |
- Primary Purpose: Screening
|
|
12 |
All |
15 Years to 80 Years (Child, Adult, Senior) |
NCT00004326 |
199/11872
UMMC-1043 |
|
August 1994 |
|
|
October 19, 1999 |
June 24, 2005 |
|
- University of Michigan Health Systems
Ann Arbor, Michigan, United States
|
| 29 |
NCT00004343 |
Unknown † |
Study of Hypercortisolism in Cushing's Syndrome and Stress-Induced Pseudo-Cushing's Syndrome |
|
|
Observational |
|
- National Center for Research Resources (NCRR)
- Oregon Health and Science University
|
NIH / Other |
- Primary Purpose: Screening
|
|
40 |
All |
Child, Adult, Senior |
NCT00004343 |
NCRR-M01RR00334-0028
OHSU-3324 |
|
October 1999 |
|
|
October 19, 1999 |
June 24, 2005 |
|
- Oregon Health Sciences University
Portland, Oregon, United States
|
| 30 |
NCT01990560 |
Completed
Has Results |
Glucocorticoid Receptor Blockade With Mifepristone in Patients With Mild Adrenal Hypercortisolism |
|
|
Interventional |
Phase 4 |
- Icahn School of Medicine at Mount Sinai
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- A1C Level
- HOMA-IR
- Waist Circumference
- (and 8 more...)
|
8 |
All |
18 Years and older (Adult, Senior) |
NCT01990560 |
GCO 13-1061 |
|
November 2013 |
September 2016 |
September 2016 |
November 21, 2013 |
March 2, 2018 |
March 2, 2018 |
- Icahn School of Medicine at Mount Sinai
New York, New York, United States
|
| 31 |
NCT00682084 |
Terminated |
Insulin Sensitivity and Substrate Metabolism in Patients With Cushing's Syndrome |
- Cushing's Syndrome
- Insulin Resistance
|
|
Observational |
|
- University of Aarhus
- Aarhus University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Insulin sensitivity
- Glucose tolerance, QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism.
|
1 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT00682084 |
MM-ISC-20070131 |
|
April 2008 |
November 2016 |
November 2016 |
May 22, 2008 |
December 22, 2017 |
|
- Department of Endocrinology
Aarhus C, Aarhus, Denmark
|
| 32 |
NCT01371565 |
Completed
Has Results |
Compassionate Use of CORLUX® (Mifepristone) in the Treatment of Signs and Symptoms of Endogenous Cushing's Syndrome |
- Cushing's Disease
- Cushing's Syndrome
|
|
Interventional |
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Participants With Adverse Events
|
4 |
All |
18 Years and older (Adult, Senior) |
NCT01371565 |
C1073-405 |
|
November 2010 |
June 2012 |
September 2012 |
June 13, 2011 |
March 18, 2014 |
November 20, 2013 |
- The Center for Diabetes and Endocrine Care
Hollywood, Florida, United States - Sinai Hospital of Baltimore
Baltimore, Maryland, United States - University of Michigan Medical Center
Ann Arbor, Michigan, United States - (and 2 more...)
|
| 33 |
NCT02335996 |
Recruiting |
Hypercortisolism and Epicardial Adipose Tissue |
|
- Biological: Blood samples for measuring adiponectin, leptin and omentin plasma
- Device: MRI at 3 Tesla
|
Interventional |
Not Applicable |
- Assistance Publique Hopitaux De Marseille
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- measuring the volume of epicardial adipose tissue, as measured by MRI to 3 Tesla.
- Assess insulin resistance by the blood sugar and insulin levels
- Assess cardiovascular risk by a blood complete lipid profile
- (and 2 more...)
|
42 |
All |
18 Years and older (Adult, Senior) |
NCT02335996 |
2014-23
2014-A01302-45
RCAPHM14_0343 |
Hyper-Cor |
December 2014 |
December 2017 |
December 2017 |
January 12, 2015 |
September 1, 2017 |
|
- Assistance Publique Hôpitaux Marseille
Marseille, France
|
| 34 |
NCT03364803 |
Recruiting |
Collecting Information About Treatment Results for Patients With Cushing's Syndrome |
- Cushing's Disease
- Cushing Syndrome
- Cushing Disease
|
- Other: Cushing's QoL (Quality of Life Questionnaire)
- Other: Nottingham Health Profile (NHP)
- Other: Hospital Anxiety and Depression Scale (HADS)
- (and 8 more...)
|
Observational |
|
- Memorial Sloan Kettering Cancer Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Collection of data on Cushing's Syndrome participants before and over time after surgical, medication, and/or radiation therapy.
|
200 |
All |
14 Years and older (Child, Adult, Senior) |
NCT03364803 |
17-592 |
|
November 28, 2017 |
November 28, 2024 |
November 28, 2024 |
December 7, 2017 |
March 15, 2018 |
|
- Memorial Sloan - Kettering Cancer Center
New York, New York, United States
|
| 35 |
NCT01246739 |
Recruiting |
Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome |
- Adrenal Tumour With Mild Hypercortisolism
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement of blood pressure
- Normalization of diabetes mellitus
- Decreased body mass index (BMI) to < 30
- (and 7 more...)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT01246739 |
2010/297 |
AUSC |
June 2011 |
December 2020 |
December 2022 |
November 23, 2010 |
January 16, 2018 |
|
- Århus University Hospital
Århus, Denmark - Haukeland University Hospital
Bergen, Norway - Sahlgrenska University Hospital
Gothenburg, Sweden - Skåne University Hospital-Lund, Department of Surgery
Lund, Sweden
|
| 36 |
NCT02889224 |
Completed |
In Vivo Study of Interactions Between the Endocannabinoid System and the Corticotropic Axis in Man |
|
- Other: Obese
- Procedure: Hypercortisolism
- Other: Hydrocortisone
- Other: Control
|
Interventional |
Not Applicable |
- University Hospital, Bordeaux
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Fluctuations of 2-AG (2-arachidonoyl-Glycérol) plasma concentration in relationship to cortisol plasma concentration in obese arm compare to hypercortisolism arm.
- Measurement of plasma concentration of AEA (Anandamide), OEA (Oleoyl-EthanolAmide) and PEA (Palmitoyl-EthanolAmide) endocannabinoïds associated with variations of plasma cortisol in hypercortisolism arm
- Measurement of plasma concentration of AEA (Anandamide), OEA (Oleoyl-EthanolAmide) and PEA (Palmitoyl-EthanolAmide) endocannabinoïds associated with variations of plasma cortisol in hydrocortisone arm
- Measurement of plasma concentration of AEA (Anandamide), OEA (Oleoyl-EthanolAmide) and PEA (Palmitoyl-EthanolAmide) endocannabinoïds in control arm who have no cortisol production problem.
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02889224 |
CHUBX 2010/34 |
VISECA |
February 2012 |
September 2013 |
September 2013 |
September 5, 2016 |
September 5, 2016 |
|
- Service d'Endocrinologie, Hopital Haut-Leveque
Pessac, France
|
| 37 |
NCT00006278 |
Completed |
Study of Cushing's Syndrome Not Related to ACTH Production |
- Cushing's Syndrome
- Healthy
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
18 |
All |
Child, Adult, Senior |
NCT00006278 |
000178
00-CH-0178 |
|
September 2000 |
|
September 2002 |
September 15, 2000 |
March 4, 2008 |
|
- National Institute of Child Health and Human Development (NICHD)
Bethesda, Maryland, United States
|
| 38 |
NCT01504555 |
Recruiting |
Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome? |
- Cushing's Syndrome
- Adrenal Incidentalomas
- Alcoholism
- Obesity
|
|
Observational |
|
- Haukeland University Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- The difference (in percent) in false positive DXM-tests comparing the outcome of all tests with all tests excluding those with s-DXM below the the cut-off specified below.
- Calculate the positive likelihood ratio [(1-sensitivity)/specificity] for the short DXM-test in the assessment of Cushing's syndrome (CS), after excluding those with s-DXM below the DXM cut-off specified in the primary endpoint.
- Calculate the negative likelihood ratio [(1-sensitivity)/specificity] for the short DXM-test in the assessment of Cushing's syndrome, after excluding those with s-DXM below the DXM cut-off specified in the primary endpoint.
- (and 13 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT01504555 |
2011/1810 |
DXM |
October 2011 |
September 2017 |
September 2017 |
January 5, 2012 |
September 26, 2016 |
|
- Haukeland Universitetssykehus- Rusmedisinsk avdeling
Bergen, Norway - Haukeland Universitetssykehus- Endokrinologisk avdeling
Bergen, Norway - Institutt for farmakologi
Bergen, Norway - Haukeland University Hospital- Hormonlaboratory
Bergen, Norway
|
| 39 |
NCT02001051 |
Completed |
Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism |
- Subclinical Hypercortisolism
- Cushing Syndrome
- Adrenal Neoplasm
|
- Procedure: Adrenalectomy
- Other: Observation
|
Interventional |
Phase 2 |
- National Cancer Institute (NCI)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- CC-OADRIS
- National Institutes of Health Clinical Center (CC)
|
NIH / Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of patients that have normalization and/or improvementof metabolic complications after adrenalectomy.
- Proportion of patients who are found to have adrenal cancer afteradrenalectomy.
- Proportion of patients who were diagnosed with subclinicalhypercortisolism by FDG PET/CT scan
- (and 4 more...)
|
4 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02001051 |
140021
14-C-0021 |
|
November 27, 2013 |
August 22, 2017 |
February 26, 2018 |
December 4, 2013 |
March 2, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 40 |
NCT03229395 |
Completed |
Alterations of Muscle Secretome Associated With Muscle Atrophy Caused by Glucocorticoids |
|
|
Observational |
|
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Measurement of BMI in kg/m^2
- Evaluation of quality of life of Cushing's patients
- Measure of body lean mass of Cushing's and control patients
- (and 3 more...)
|
35 |
All |
18 Years and older (Adult, Senior) |
NCT03229395 |
UCL-MYOSECRET 2014-1 |
MYOSECRET |
January 2, 2014 |
July 13, 2017 |
July 18, 2017 |
July 25, 2017 |
July 25, 2017 |
|
- De Barsy Marie
Brussels, Belgium
|
| 41 |
NCT00081341 |
Completed |
Cognition, Steroids, and Imaging in Cushings Disease |
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
NIH |
- Time Perspective: Prospective
|
|
|
All |
9 Years and older (Child, Adult, Senior) |
NCT00081341 |
51337DK (completed) |
|
|
|
December 2002 |
April 12, 2004 |
February 15, 2010 |
|
- General Clinical Research Center, University of Michigan Health System
Ann Arbor, Michigan, United States
|
| 42 |
NCT00088608 |
Completed |
A Study to Assess SOM230 in Patients With Pituitary Cushing's Disease |
|
|
Interventional |
Phase 2 |
- Novartis Pharmaceuticals
- Novartis
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Urinary Free Cortisol after 15 days of treatment
- Serum cortisol
- ACTH
- (and 5 more...)
|
26 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00088608 |
CSOM230B2208 |
|
April 2004 |
June 2006 |
|
August 2, 2004 |
November 7, 2016 |
|
- Cedars-Sinai Pituitary Center
Los Angeles, California, United States - Massachusetts General Hospital NE Unit
Boston, Massachusetts, United States - Oregon Health & Science University
Portland, Oregon, United States - (and 2 more...)
|
| 43 |
NCT02202902 |
Recruiting |
Cardiac Steatosis in Cushing's Syndrome |
- Endocrine System Disease
- Cardiovascular Imaging
|
- Other: 1H magnetic resonance spectroscopy and CMRI
|
Interventional |
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Left Ventricular (LV) intramyocardial triglyceride / water ratio LV intramyocardial triglyceride / water ratio
- Left Ventricular intramyocardial fatt fraction (Dixon)
- Subcutaneous and visceral abdominal fatt
- Cardiac morphology and function
|
60 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02202902 |
AOR12017
2013-A01023-42 |
CORTICOEUR |
June 2014 |
December 2017 |
December 2017 |
July 29, 2014 |
September 29, 2016 |
|
- AP-HP, Bicêtre Hospital
Le Kremlin-Bicêtre, France
|
| 44 |
NCT02468193 |
Recruiting |
Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome |
- Cushing's Syndrome
- Ectopic Corticotropin Syndrome
- Adrenal Adenoma
- (and 3 more...)
|
|
Interventional |
Phase 2 |
- Novartis Pharmaceuticals
- Novartis
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percent change in the mean Urine Free Cortisol (mUFC) at Week 12
- Percent change in the mUFC at Week 24 and Week 48
- Change from baseline in the mUFC at Week 12, Week 24 and Week 48
- (and 7 more...)
|
10 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02468193 |
CLCI699C1201 |
|
September 24, 2015 |
June 27, 2018 |
July 18, 2018 |
June 10, 2015 |
February 12, 2018 |
|
- Novartis Investigative Site
Fukuoka city, Fukuoka, Japan - Novartis Investigative Site
Fukushima-city, Fukushima, Japan - Novartis Investigative Site
Kobe-city, Hyogo, Japan - (and 4 more...)
|
| 45 |
NCT03111810 |
Recruiting |
Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition |
- Iatrogenic Cushing's Disease
|
- Drug: AZD4017 and prednisolone
- Drug: Placebo Oral Tablet and prednisolone
|
Interventional |
Phase 2 |
- University of Oxford
- AstraZeneca
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Changes in the detrimental side effects of prednisolone by AZD4017.
- Changes in hepatic insulin sensitivity by AZD4017 when given with prednisolone (20mg) compared to prednisolone (20mg) given alone.
- Changes in blood pressure associated with prednisolone and AZD4017 administration
- (and 7 more...)
|
32 |
Male |
18 Years to 60 Years (Adult) |
NCT03111810 |
212634 |
TICSI |
May 25, 2017 |
December 2018 |
January 2019 |
April 13, 2017 |
October 6, 2017 |
|
- University of Oxford
Oxford, United Kingdom
|
| 46 |
NCT02574793 |
Completed |
Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects |
|
- Device: continuous glucose monitoring
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Continuous glucose profiles of mean data of 24-hour continuous glucose monitoring by the CGMS Gold
- The mean amplitude of glycemic excursion of newly diagnosed GH adenoma patients
- The mean amplitude of glycemic excursion of newly diagnosed Cushing Syndrome patients during the 3 days monitored by CGMS Gold
- (and 2 more...)
|
60 |
All |
Child, Adult, Senior |
NCT02574793 |
KY2015-152 |
|
December 1, 2014 |
December 31, 2017 |
January 7, 2018 |
October 14, 2015 |
January 23, 2018 |
|
- Xiaolong Zhao
Jing'an, Shanghai, China
|
| 47 |
NCT03162068 |
Recruiting |
Cushing's Osteoporosis Specificities |
- Osteoporosis in Cushing's Syndrome
- Osteoporosis in Post-menopausal Women
|
- Other: Osteodensitometry and pQCT
|
Observational |
|
- University Hospital, Clermont-Ferrand
- Unité de recherche GReD CNRS UMR6293 / Inserm
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Comparison of volumetric bone mineral density
- Assessment of strength bone of radius and tibia of the non-dominant limb
- Assessment of trabecular and cortical compartment
- Comparison of muscle area and surface, adipose tissue
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT03162068 |
CHU-334
2016-A01482-49 |
SOCS |
April 4, 2017 |
May 2019 |
May 2024 |
May 22, 2017 |
May 22, 2017 |
|
- CHU Clermont-Ferrand
Clermont-Ferrand, Auvergne, France
|
| 48 |
NCT02780882 |
Withdrawn |
SOM230 Ectopic ACTH-producing Tumors |
|
|
Interventional |
Phase 2 |
- Cedars-Sinai Medical Center
- Novartis
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Evaluate the efficacy of pasireotide twice daily subcutaneous injections for normalizing 24 hour urine free cortisol in patients with ectopic ACTH-producing tumors
- Number of participants with abnormal laboratory values for urine free cortisol
- Number of participants with abnormal laboratory values for serum cortisol levels
- (and 12 more...)
|
0 |
All |
18 Years and older (Adult, Senior) |
NCT02780882 |
Pro34493 |
|
December 2015 |
December 2018 |
June 2019 |
May 24, 2016 |
January 26, 2018 |
|
- Cedars-Sinai Medical Center
Los Angeles, California, United States
|
| 49 |
NCT00457587 |
Active, not recruiting |
Preclinical Study Towards an Immunotherapy in Adrenocortical Carcinoma |
- Adrenocortical Carcinoma
- Cushing's Syndrome
|
|
Observational |
|
- University of Wuerzburg
- Deutsche Krebshilfe e.V., Bonn (Germany)
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- To find reasonable antigens for a vaccination therapy in ACC
- To investigate the role of tumor-induced suppression in ACC
|
70 |
All |
18 Years and older (Adult, Senior) |
NCT00457587 |
Wue-Immuno-ACC-83/05 |
|
September 2005 |
December 2011 |
December 2017 |
April 6, 2007 |
May 9, 2017 |
|
- Dept. of Medicine I, University of Wuerzburg
Wuerzburg, Germany
|
| 50 |
NCT02618694 |
Completed |
Efficacy and Safety of Posterior Retroperitoneoscopic Adrenalectomy: A Comparative Study |
- Adrenal Mass
- Adrenal Disease
- Pheochromocytoma
- Cushing Syndrome
|
- Procedure: Posterior retroperitoneoscopic adrenalectomy
- Procedure: Transperitoneal laparoscopic adrenalectomy
|
Interventional |
Not Applicable |
- Suez Canal University
- Alexandria University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Mean operative time
- Mean amount of intraoperative blood loss
- Mean days of postoperative hospital stay
- (and 3 more...)
|
13 |
All |
Child, Adult, Senior |
NCT02618694 |
2380 |
PostLapAdrnl |
April 2015 |
June 2016 |
December 2016 |
December 1, 2015 |
March 3, 2017 |
|
- Alexandria Main University Hospital
Alexandria, Egypt - Suez Canal University Hospital
Ismailia, Egypt
|
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