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66 studies found for:    "Congenital aplastic anemia"
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Rank Status Study
21 Completed Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
Conditions: Childhood Acute Erythroleukemia (M6);   Childhood Acute Megakaryocytic Leukemia (M7);   Childhood Acute Minimally Differentiated Myeloid Leukemia (M0);   Childhood Acute Monoblastic Leukemia (M5a);   Childhood Acute Monocytic Leukemia (M5b);   Childhood Acute Myeloblastic Leukemia With Maturation (M2);   Childhood Acute Myeloblastic Leukemia Without Maturation (M1);   Childhood Acute Myelomonocytic Leukemia (M4);   Childhood Myelodysplastic Syndromes;   Chronic Myelomonocytic Leukemia;   de Novo Myelodysplastic Syndromes;   Fanconi Anemia;   Refractory Anemia;   Refractory Anemia With Excess Blasts;   Refractory Anemia With Excess Blasts in Transformation;   Refractory Anemia With Ringed Sideroblasts;   Secondary Myelodysplastic Syndromes;   Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Intervention: Other: laboratory biomarker analysis
22 Terminated
Has Results
Stem Cell Transplantation for Fanconi Anemia
Condition: Fanconi Anemia
Interventions: Procedure: Hematopoietic Stem Cell Transplant;   Procedure: Thymic Shielding During Radiation;   Procedure: Total Body Irradiation;   Drug: Cyclophosphamide, Fludarabine
23 Completed Blood Cell Collection for Future Use in Individuals With Fanconi Anemia
Condition: Fanconi Anemia
Interventions: Procedure: PBSC Collection;   Procedure: Bone Marrow Harvest;   Device: CliniMacs Cell Selection System
24 Terminated Safety and Efficacy Trial of Danazol in Patients With Fanconi Anemia or Dyskeratosis Congenita
Conditions: Fanconi Anemia;   Dyskeratosis Congenita
Intervention: Drug: danazol
25 Recruiting HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy
Conditions: Fanconi Anemia;   Severe Marrow Failure;   Myelodysplastic Syndrome (MDS);   Acute Myelogenous Leukemia (AML)
Interventions: Drug: Busulfan;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: rabbit ATG;   Drug: G-CSF;   Biological: Peripheral blood stem cell
26 Completed Mobilization and Collection of Peripheral Blood Stem Cells in Patients With Fanconi Anemia Using G-CSF and AMD3100
Condition: Fanconi Anemia
Interventions: Drug: AMD3100;   Device: AmCell CliniMACs
27 Terminated Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCT
Interventions: Procedure: CD34 selected haploidentical PBSCT;   Drug: Fludarabine;   Biological: T cell infusion;   Biological: Campath 1h;   Biological: anti-CD45
28 Active, not recruiting Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed by Unrelated Donor Stem Cell Transplant in Treating Patients With Fanconi Anemia
Conditions: Adult Acute Myeloid Leukemia in Remission;   Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities;   Adult Acute Myeloid Leukemia With Del(5q);   Adult Acute Myeloid Leukemia With Inv(16)(p13;q22);   Adult Acute Myeloid Leukemia With t(15;17)(q22;q12);   Adult Acute Myeloid Leukemia With t(16;16)(p13;q22);   Adult Acute Myeloid Leukemia With t(8;21)(q22;q22);   Childhood Acute Myeloid Leukemia in Remission;   Childhood Myelodysplastic Syndromes;   Fanconi Anemia;   Previously Treated Myelodysplastic Syndromes
Interventions: Drug: fludarabine phosphate;   Drug: cyclosporine;   Radiation: total-body irradiation;   Procedure: allogeneic bone marrow transplantation;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: peripheral blood stem cell transplantation;   Drug: mycophenolate mofetil
29 Active, not recruiting Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant, Mycophenolate Mofetil, and Cyclosporine in Treating Patients With Fanconi Anemia
Conditions: Acute Myeloid Leukemia in Remission;   de Novo Myelodysplastic Syndrome;   Fanconi Anemia;   Previously Treated Myelodysplastic Syndrome
Interventions: Procedure: Allogeneic Bone Marrow Transplantation;   Drug: Cyclophosphamide;   Drug: Cyclosporine;   Drug: Fludarabine Phosphate;   Other: Laboratory Biomarker Analysis;   Drug: Mycophenolate Mofetil;   Procedure: Nonmyeloablative Allogeneic Hematopoietic Stem Cell Transplantation;   Radiation: Total-Body Irradiation
30 Completed
Has Results
Hematopoietic Stem Cell Transplantation for Treatment of Patients With Fanconi Anemia Lacking a Genotypically Identical Donor, Using Total Body Irradiation, Cyclophosphamide and Fludarabine
Condition: Fanconi Anemia
Interventions: Drug: Cyclophosphamide;   Drug: Fludarabine;   Radiation: Total body irradiation (TBI)
31 Recruiting Clinical Phase II Trial to Evaluate CD34+ Cells Mobilization and Collection in Patients With Fanconi Anemia for Subsequent Transduction With a Lentiviral Vector Carring FANCA Gene. FANCOSTEM-1
Condition: Fanconi Anemia
Interventions: Drug: filgrastim;   Drug: plerixafor
32 Unknown  Fanconi Anemia Transplant Lacking Genotypically Identical Donor
Condition: Fanconi Anemia
Intervention: Device: Miltenyi CliniMACs device
33 Completed Evaluation of Fanconi Syndrome and Cystinosis
Conditions: Cystinosis;   Fanconi Syndrome
34 Unknown  Phase I Study of Amifostine in Patients With Bone Marrow Failure Related to Fanconi's Anemia
Condition: Fanconi's Anemia
Intervention: Drug: amifostine
35 Completed Study of Allogeneic Bone Marrow Transplantation Following Cyclophosphamide and Radiotherapy in Patients With Fanconi's Anemia
Condition: Fanconi's Anemia
Interventions: Drug: cyclophosphamide;   Procedure: Allogeneic Bone Marrow Transplantation
36 Completed Study of Allogeneic Bone Marrow Transplantation Following Cyclophosphamide and Radiotherapy in Patients With Myelodysplastic Syndrome and Acute Leukemia Related to Fanconi's Anemia
Conditions: Fanconi's Anemia;   Myelodysplastic Syndromes;   Leukemia, Nonlymphocytic, Acute;   Leukemia, Lymphocytic, Acute
Interventions: Drug: cyclophosphamide;   Procedure: Allogeneic Bone Marrow Transplantation
37 Unknown  Phase I Pilot Study of CD34 Enriched, Fanconi's Anemia Complementation Group C Gene Transduced Autologous Peripheral Blood Stem Cell Transplantation in Patients With Fanconi's Anemia
Condition: Fanconi's Anemia
Interventions: Drug: filgrastim;   Genetic: Autologous stem cells transduced with FACC retroviral vector;   Procedure: Autologous Stem Cell Transplantation
38 Completed Phase I/II Study of Total Body Irradiation, Cyclophosphamide, and Fludarabine Followed by Alternate Donor Hematopoietic Cell Transplantation in Patients With Fanconi's Anemia
Condition: Fanconi's Anemia
Interventions: Drug: anti-thymocyte globulin;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: filgrastim;   Drug: fludarabine;   Drug: methylprednisolone
39 Suspended
Has Results
Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation
Conditions: Thalassemia;   Sickle Cell Disease;   Glanzmann Thrombasthenia;   Wiskott-Aldrich Syndrome;   Chronic-granulomatous Disease;   Severe Congenital Neutropenia;   Leukocyte Adhesion Deficiency;   Schwachman-Diamond Syndrome;   Diamond-Blackfan Anemia;   Fanconi Anemia;   Dyskeratosis-congenita;   Chediak-Higashi Syndrome;   Severe Aplastic Anemia
Intervention: Drug: Alefacept
40 Completed Assessing Immune Function in Young Patients With Cytopenia That Did Not Respond to Treatment
Conditions: Dyskeratosis Congenita;   Fanconi Anemia;   Myelodysplastic Syndromes;   Pearson Marrow-pancreas Syndrome;   Shwachman-diamond Syndrome
Interventions: Genetic: polymerase chain reaction;   Other: flow cytometry;   Other: immunologic technique;   Procedure: biopsy

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