| 1 |
NCT01464606 |
Recruiting |
International Pleuropulmonary Blastoma (PPB) Treatment and Biology Registry |
|
- Drug: Vincristine
- Drug: Dactinomycin
- Drug: Cyclophosphamide
- (and 2 more...)
|
Interventional |
Not Applicable |
- Children's Hospitals and Clinics of Minnesota
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Event-free survival
- Overall response to chemotherapy, and survival
|
125 |
All |
up to 21 Years (Child, Adult) |
NCT01464606 |
PPB Reg Tx-Biol-001 |
|
September 2011 |
December 2019 |
December 2019 |
November 3, 2011 |
December 21, 2017 |
|
- Children's Hospitals and Clinics of Minnesota
Minneapolis, Minnesota, United States
|
| 2 |
NCT03044834 |
Recruiting |
Review of the Paediatric Pleuropulmonary Blastoma French Series |
|
|
Observational |
|
- Rennes University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Overall survival
- Progression free survival
- State of PPB surgical care
- Radiology sign
|
40 |
All |
1 Year to 17 Years (Child) |
NCT03044834 |
35RC15_3009_PPB
15.18
15.468
915465 |
PPB |
January 9, 2017 |
July 9, 2018 |
July 9, 2018 |
February 7, 2017 |
April 9, 2018 |
|
- Angers University Hospital
Angers, France - Bordeaux University Hospital
Bordeaux, France - Caen University Hospital
Caen, France - (and 15 more...)
|
| 3 |
NCT01247597 |
Recruiting |
DICER1-related Pleuropulmonary Blastoma Cancer Predisposition Syndrome: A Natural History Study |
- Pleuropulmonary Blastoma
- Cystic Nephroma
- Ovarian Sertoli-Leydig Cell Tumors
- (and 2 more...)
|
|
Observational |
|
- National Cancer Institute (NCI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Family-Based
- Time Perspective: Other
|
- Clinical Phenotype
- DICER1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome
- Genetic & Environmental Interactions
- (and 3 more...)
|
1500 |
All |
up to 100 Years (Child, Adult, Senior) |
NCT01247597 |
110034
11-C-0034 |
|
November 23, 2010 |
|
|
November 24, 2010 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 4 |
NCT00565903 |
Recruiting |
Elucidating the Genetic Basis of the Pleuropulmonary Blastoma (PPB) Familial Cancer Syndrome |
- Pleuropulmonary Blastoma
- Cystic Nephroma
- Sertoli-Leydig Cell Tumor of Ovary
- (and 7 more...)
|
|
Observational |
|
- D. Ashley Hill, M.D.
- Children's Research Institute
|
Other |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
- Identify the genetic factors which contribute to the development or progression of pleuropulmonary blastoma
- Define the clinical features of the pleuropulmonary blastoma (PPB) familial cancer syndrome.
|
2000 |
All |
up to 95 Years (Child, Adult, Senior) |
NCT00565903 |
05-0192 / 201012830 |
PPB |
March 2005 |
December 2018 |
December 2020 |
November 30, 2007 |
July 19, 2017 |
|
- Children's National Medical Center
Washington, D.C., District of Columbia, United States
|
| 5 |
NCT02452554 |
Active, not recruiting |
Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma |
- Pleuropulmonary Blastoma
- Recurrent Malignant Peripheral Nerve Sheath Tumor
- Recurrent Neuroblastoma
- (and 3 more...)
|
- Other: Laboratory Biomarker Analysis
- Biological: Lorvotuzumab Mertansine
- Other: Pharmacological Study
|
Interventional |
Phase 2 |
- Children's Oncology Group
- National Cancer Institute (NCI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of toxicities of lorvotuzumab mertansine, using the NCI Common Terminology Criteria for Adverse Events version 4.0
- Objective response by Response Evaluation Criteria in Solid Tumors version 1.1
|
62 |
All |
12 Months to 30 Years (Child, Adult) |
NCT02452554 |
ADVL1522
NCI-2015-00746
U10CA180886 |
|
October 2015 |
March 2019 |
March 2020 |
May 22, 2015 |
March 16, 2018 |
|
- Children's Hospital of Alabama
Birmingham, Alabama, United States - Arkansas Children's Hospital
Little Rock, Arkansas, United States - Southern California Permanente Medical Group
Downey, California, United States - (and 66 more...)
|
| 6 |
NCT03382158 |
Recruiting |
International PPB Registry for PPB, DICER1 and Associated Conditions |
- Pleuropulmonary Blastoma
- Sertoli-Leydig Cell Tumor
- DICER1 Syndrome
- (and 10 more...)
|
|
Observational |
|
- Children's Hospitals and Clinics of Minnesota
- Children's Research Institute
- Washington University School of Medicine
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Event-free survival
- Overall response to chemotherapy
- Overall survival
- (and 4 more...)
|
100 |
All |
Child, Adult, Senior |
NCT03382158 |
FDAAA |
|
December 6, 2016 |
December 6, 2023 |
December 6, 2026 |
December 22, 2017 |
December 22, 2017 |
|
- Children;s Minnesota
Minneapolis, Minnesota, United States
|
| 7 |
NCT01353300 |
Completed |
Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing Cancer |
- Brain and Central Nervous System Tumors
- Hereditary Wilms Tumor
- Kidney Cancer
- (and 4 more...)
|
- Genetic: DNA analysis
- Genetic: cytogenetic analysis
- Genetic: gene expression analysis
- (and 6 more...)
|
Observational |
|
- Children's Oncology Group
- National Cancer Institute (NCI)
|
Other / NIH |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Relationship between DICER1 mutations and tumor pathogenesis in cystic nephromas and cystic partially differentiated nephroblastomas outside of families with PPB nephroblastomas
|
31 |
All |
up to 120 Years (Child, Adult, Senior) |
NCT01353300 |
AREN11B2
COG-AREN11B2
NCI-2011-02854 |
|
May 2011 |
July 2016 |
|
May 13, 2011 |
July 11, 2016 |
|
|
| 8 |
NCT03044769 |
Recruiting |
Congenital Lung Anomalies (CLA) Swiss Database |
- Congenital Lung Malformation
- Congenital Lung Cyst
- Sequestrum
- (and 3 more...)
|
- Procedure: Malformations resection
|
Observational |
|
- University Hospital, Geneva
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in clinical of patients with CLA between different time point
- Analysis of CLA physiopathology
- Change in lung function
- (and 5 more...)
|
100 |
All |
up to 16 Years (Child) |
NCT03044769 |
CLA-2016 |
CLADatabase |
April 1, 2016 |
January 1, 2020 |
April 1, 2026 |
February 7, 2017 |
February 7, 2017 |
|
- Geneva University Hospital
Geneva, Switzerland
|
| 9 |
NCT00936052 |
Unknown † |
Hyperbaric Hyperoxygenation With Radiotherapy and Temozolomide in Adults With Newly Diagnosed Glioblastoma |
|
- Other: Hyperbaric Oxygen Therapy
|
Interventional |
Phase 2 |
- Neurological Surgery, P.C.
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- to generate preliminary data of the anti-tumor efficacy of hyperbaric oxygenation in conjunction with radiotherapy and chemotherapy,to determine median progression-free survival, to determine median survival and to determine median 2 year survival.
- to determine the health related quality of life of this treatment regimen and its influence upon subjects'' perceived level of traumatic stress throughout the course of treatment.
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT00936052 |
LIBTC-2008-2 |
HBO |
December 2008 |
December 2010 |
December 2010 |
July 9, 2009 |
July 16, 2010 |
|
- Long Island Brain Tumor Center at Neurological surgery P.C.
Commack, New York, United States - Long Island Brain Tumor Center at Neurological Surgery P.C.
Great Neck, New York, United States
|
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