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17 studies found for:    "Bannayan-Riley-Ruvalcaba syndrome" OR "Hamartoma Syndrome, Multiple"
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Study Details
Participant Details
Identifiers
Dates
Rank Status Study
1 Completed
Has Results
Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes
Conditions: Cowden's Disease;   Hamartoma Syndrome, Multiple
Interventions: Radiation: fludeoxyglucose F 18;   Drug: sirolimus;   Other: Clinical Videography
2 Completed A Phase I/II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patients With Advanced Breast Cancer
Conditions: Breast Cancer;   Advanced Solid Tumors;   Cowden Syndrome
Intervention: Drug: BEZ235
3 Completed A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer
Conditions: Solid Tumors;   Breast Cancer;   Cowden Syndrome
Intervention: Drug: BGT226
4 Recruiting French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Polyposis With SMAD 4 Gene Mutation , Serrated and Hyperplastic Polyposis
Condition: Quality of Life
Interventions: Other: Procedure surgery behavioral and genetic diagnosis;   Procedure: quality of life after different type of surgery
5 Recruiting RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome (PTEN)
Conditions: PTEN Gene Mutation;   PTEN Hamartoma Tumor Syndrome
Interventions: Drug: RAD001;   Drug: Placebo
6 Recruiting Photodynamic Therapy and Vismodegib for Multiple Basal Cell Carcinomas
Condition: Basal Cell Carcinoma
Intervention: Drug: Vismodegib
7 Active, not recruiting
Has Results
A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas
Condition: Basal Cell Carcinoma
Interventions: Drug: Vismodegib;   Drug: Placebo
8 Recruiting Natural History Study of Individuals With Autism and Germline Heterozygous PTEN Mutations
Conditions: PTEN;   ASD;   Autism;   Macrocephaly;   PTEN Hamartoma Tumor Syndrome
Intervention:
9 Completed Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas
Conditions: Basal Cell Nevus Syndrome;   Gorlin's Syndrome
Interventions: Drug: Vismodegib;   Drug: Aminolevulinic acid %20 topical solution
10 Terminated Two Studies to Determine if Verteporfin PDT is Effective & Safe in Treating Multiple Basal Cell Carcinoma of the Skin.
Conditions: Basal Cell Carcinoma;   Nevoid Basal Cell Carcinoma Syndrome;   Gorlin Syndrome
Intervention: Drug: verteporfin PDT
11 Completed The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases
Conditions: Basal Cell Carcinoma;   Keratosis Palmaris et Plantaris;   Psoriasis
Intervention:
12 Recruiting Familial Investigations of Childhood Cancer Predisposition
Conditions: Acute Leukemia;   Adenomatous Polyposis;   Adrenocortical Carcinoma;   AML;   BAP1 Tumor Predisposition Syndrome;   Carney Complex;   Choroid Plexus Carcinoma;   Constitutional Mismatch Repair Deficiency Syndrome;   Diamond-Blackfan Anemia;   DICER1 Syndrome;   Dyskeratosis Congenita;   Emberger Syndrome;   Familial Acute Myeloid Leukaemia;   Familial Adenomatous Polyposis;   Fanconi Anemia;   Familial Cancer;   Familial Wilms Tumor;   Familial Neuroblastoma;   GIST;   Hereditary Breast and Ovarian Cancer;   Hereditary Paraganglioma-Pheochromocytoma Syndrome;   Hodgkin Lymphoma;   Juvenile Polyposis;   Li-Fraumeni Syndrome;   Lynch Syndrome;   MDS;   Melanoma Syndrome;   Multiple Endocrine Neoplasia Type 1;   Multiple Endocrine Neoplasia Type 2;   Neuroblastoma;   Neurofibromatosis Type 1;   Neurofibromatosis Type II;   Nevoid Basal Cell Carcinoma Syndrome;   Non Hodgkin Lymphoma;   Noonan Syndrome and Other Rasopathy;   Overgrowth Syndromes;   Pancreatic Cancer;   Peutz-Jeghers Syndrome;   Pheochromocytoma/Paraganglioma;   PTEN Hamartoma Tumor Syndrome;   Retinoblastoma;   Rhabdoid Tumor Predisposition Syndrome;   Rhabdomyosarcoma;   Rothmund-Thomson Syndrome;   Tuberous Sclerosis;   Von Hippel-Lindau Disease
Intervention:
13 Recruiting Study of ARQ 092 in Patients With Overgrowth Diseases and Vascular Anomalies
Conditions: Proteus Syndrome;   PIK3CA-Related Overgrowth Spectrum (PROS);   Growth Disorders
Intervention: Drug: ARQ 092
14 Enrolling by invitation Dose Finding Trial of ARQ 092 in Children and Adults With Proteus Syndrome
Condition: Proteus Syndrome
Intervention: Drug: ARQ 092
15 Completed Informed Consent for Whole Genome Sequencing: Ideals and Norms Referenced by Early Participants
Conditions: Coronary Artery Disease;   Proteus Syndrome;   Coffin - Sins Syndrome;   Familial Isolated Hyperparathyroidism;   Dubouitz Syndrome
Intervention:
16 Recruiting Study of Proteus Syndrome and Related Congenital Disorders
Conditions: Growth Disorder;   Mental Retardation;   Multiple Abnormalies
Intervention:
17 Active, not recruiting Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer
Conditions: Familial Ovarian Cancer;   Familial Breast Cancer;   BRCA1-associate Malignancies;   BRCA2-associated Malignancies
Intervention:

Study has passed its completion date and status has not been verified in more than two years.