| 1 |
NCT01669889 |
Completed |
A Non-Drug Study on the Relationship Between Exploratory Biomarkers and Functional Dimensions in Individuals With Autistic Disorder or Asperger's Syndrome |
- Healthy Volunteer, Autistic Disorder, Asperger's Syndrome
|
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Behavior assessment ratings
- Cognition assessment ratings
|
38 |
Male |
18 Years to 45 Years (Adult) |
NCT01669889 |
BP28421 |
|
January 2013 |
December 2013 |
December 2013 |
August 21, 2012 |
November 2, 2016 |
|
- Los Ageles, California, United States
- New Haven, Connecticut, United States
- New York, New York, United States
|
|
| 2 |
NCT00505830 |
Unknown † |
Evaluation of the French Version of Screening Questionnaires for Autism and Asperger Syndrome: AQ, EQ and SQ |
|
|
Observational
|
|
- Groupe Francais d'Epidemiologie Psychiatrique
- Joint Clinical Research Center
|
Other |
- Observational Model: Defined Population
- Primary Purpose: Screening
- Time Perspective: Longitudinal
- Time Perspective: Prospective
|
|
450 |
All |
12 Years to 18 Years (Child, Adult) |
NCT00505830 |
Autisme AQ |
|
July 2007 |
|
July 2009 |
July 25, 2007 |
July 25, 2007 |
|
- Centre Hospitalier Saint Jean de Dieu
Lyon, France
|
|
| 3 |
NCT02800681 |
Recruiting |
Psychopathological Differences Between Asperger Syndrome and Schizotypal Disorder in an Adult Sample |
- Asperger Syndrome
- Autism Spectrum Disorder
- Schizotypal Personality Disorder
|
- Other: Expert panel evaluation
- Other: Semi-structured psychopathological interviews
- Other: Self-administered rating scales
- Other: Other general interviewer ratings
|
Observational
|
|
- Mental Health Services in the Capital Region, Denmark
- The Danish Autism Centre
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Level of altered experiences
- Pattern of most occurring altered experiences
- Autism Spectrum symptom load
- (and 4 more...)
|
100 |
All |
18 Years to 30 Years (Adult) |
NCT02800681 |
E-61120-06 |
|
June 2016 |
August 2018 |
March 2019 |
June 15, 2016 |
March 21, 2018 |
|
- Mental Health Centre Ballerup, Mental Health Services, The Capitol Region, Copenhagen
Ballerup, Copenhagen, Denmark - The Danish Autism Centre
Herlev, Denmark
|
|
| 4 |
NCT00808782 |
Completed |
The Use of rTMS to Improve Theory of Mind Among Adults With Autism and Asperger's Disorder |
- Autistic Disorder
- Asperger's Disorder
|
- Device: Deep rTMS
- Device: Sham rTMS
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Theory of Mind Neurobehavioural Battery
- Autism Spectrum Quotient
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00808782 |
277/07 |
|
December 2008 |
October 2012 |
October 2012 |
December 16, 2008 |
February 7, 2013 |
|
- Alfred Psychiatry Research Centre
Melbourne, Victoria, Australia
|
|
| 5 |
NCT00352196 |
Completed |
Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study |
|
- Drug: Risperidone
- Other: Magnetic Resonance Spectroscopy
|
Interventional
|
Phase 4 |
- Augusta University
- Ortho-McNeil Janssen Scientific Affairs, LLC
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Chang in the Scale for the Assessment of Negative Symptoms (SANS)
- Change in Positive and Negative Symptom Scale (PANNS)
- Change in Brief Psychiatric Rating Scale (BPRS)
- (and 4 more...)
|
23 |
All |
6 Years and older (Child, Adult, Older Adult) |
NCT00352196 |
RIS-EMR-4026
MCG HAC File #01-09-063 |
|
November 2001 |
May 2007 |
May 2007 |
July 14, 2006 |
January 14, 2015 |
|
- Medical College of Georgia, Dept. of Psychiatry
Augusta, Georgia, United States
|
|
| 6 |
NCT00725556 |
Completed |
The Development of Autistic Children Based on Mothers´Response in Autism Behavior Checklist |
|
|
Interventional
|
Phase 1
Phase 2 |
- Federal University of São Paulo
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To evaluate the process of development of autistic children, in a direct and indirect intervention context from mother´s response in Autism Behavior Checklist.
|
11 |
All |
3 Years to 12 Years (Child) |
NCT00725556 |
Ana Carina Tamanaha |
|
March 2006 |
March 2007 |
December 2007 |
July 30, 2008 |
August 1, 2008 |
|
- Ana Carina Tamanaha
São Paulo, Brazil
|
|
| 7 |
NCT00848874 |
Unknown † |
Portable Visual Guidance System Phase II |
- Asperger Syndrome
- High Functioning Autism
|
|
Interventional
|
Not Applicable |
- SymTrend Inc.
- University of North Carolina, Chapel Hill
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Students who use the PVGS will demonstrate improved classroom social pragmatics and executive functioning.
|
50 |
All |
11 Years to 21 Years (Child, Adult) |
NCT00848874 |
2R41MH075162
NIHM_2R41MH75162--02A1 |
PVGS-II |
September 2008 |
June 2009 |
April 2010 |
February 20, 2009 |
February 20, 2009 |
|
- SymTrend, Inc.
Belmont, Massachusetts, United States
|
|
| 8 |
NCT02826148 |
Completed |
Validation of the French Adaptation of the RAADS-R Scale : Scale of Asperger Syndrome Diagnosis |
|
|
Interventional
|
Not Applicable |
- University Hospital, Montpellier
- Fondation Orange
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- score at the RAADS-R scale
|
324 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02826148 |
8747 |
RAADS-R |
December 2011 |
December 2015 |
December 2015 |
July 7, 2016 |
July 7, 2016 |
|
|
|
| 9 |
NCT00211783 |
Completed |
Functional Magnetic Resonance Imaging (fMRI) for the Study of Response Inhibition, and Face and Linguistic Processing in Autism |
- Autism
- Asperger's Syndrome
|
|
Observational
|
|
- Icahn School of Medicine at Mount Sinai
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
|
71 |
All |
18 Years to 50 Years (Adult) |
NCT00211783 |
GCO# 04-0749 |
|
November 2004 |
November 2011 |
June 2012 |
September 21, 2005 |
June 28, 2012 |
|
- Mount Sinai School of Medicine
New York, New York, United States
|
|
| 10 |
NCT00280670 |
Completed |
CBT for Comorbid Anxiety Disorders in Children With Autism, Asperger Syndrome, or PDD-NOS |
- Autistic Disorder
- Asperger Syndrome
- Anxiety Disorders
|
- Behavioral: Cognitive-behavioral therapy
|
Interventional
|
Phase 2 |
- University of California, Los Angeles
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Score on anxiety diagnostic interview after treatment or waitlist
- Score on anxiety rating scale after treatment or waitlist
- Score on daily living skills rating scale after treatment or waitlist
- Score on children's social functioning and service use after treatment or waitlist
|
20 |
All |
7 Years to 11 Years (Child) |
NCT00280670 |
R03MH075806-01 |
BIACA |
January 2005 |
August 2008 |
August 2009 |
January 23, 2006 |
April 2, 2012 |
|
- University of California, Los Angeles
Los Angeles, California, United States
|
|
| 11 |
NCT01177969 |
Completed
Has Results |
Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents |
- Anxiety Disorders in Youth With Autism, Asperger's Syndrome, and Pervasive Developmental Disorder Not Otherwise Specified
|
- Behavioral: Cognitive-Behavioral Therapy
- Behavioral: Wait-list
|
Interventional
|
Phase 1
Phase 2 |
- University of South Florida
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- University of California, Los Angeles
- University of Miami
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pediatric Anxiety Rating Scale.
- Anxiety Disorders Interview Schedule: Child and Parent Versions
|
33 |
All |
11 Years to 14 Years (Child) |
NCT01177969 |
1R34HD065274-01 |
|
November 2009 |
April 2014 |
April 2014 |
August 9, 2010 |
July 1, 2014 |
July 1, 2014 |
- Univeristy of California at Los Angeles
Los Angeles, California, United States - University of South Florida
St. Petersburg, Florida, United States
|
|
| 12 |
NCT01337700 |
Completed |
Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism |
- Autism Spectrum Disorder
- Asperger Syndrome
- Aspergers Syndrome
|
- Drug: Milnacipran
- Drug: Placebo
|
Interventional
|
Phase 4 |
- Montefiore Medical Center
- Forest Laboratories
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Score on Conners Adults Attention Deficit Hyperactivity Disorder (ADHD) Rating Scale
- Aberrant Behavior Checklist - Irritability Scale
- Yale-Brown Obsessive Compulsive Scale (YBOCS)- Compulsion Subscale
- (and 4 more...)
|
10 |
All |
18 Years to 50 Years (Adult) |
NCT01337700 |
SAV-MD-21
10-09-299 |
|
February 2011 |
July 2014 |
July 2014 |
April 19, 2011 |
November 20, 2014 |
|
- Montefiore Medical Center, Albert Einstein College of Medicine
Bronx, New York, United States
|
|
| 13 |
NCT01592773 |
Terminated
Has Results |
Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) |
- Autism Spectrum Disorder (ASD)
- Autism
- Autistic Disorder
- (and 4 more...)
|
- Drug: Memantine Hydrochloride (HCl)
|
Interventional
|
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patients With Any Treatment-emergent Adverse Event
|
747 |
All |
6 Years to 12 Years (Child) |
NCT01592773 |
MEM-MD-69 |
|
October 2012 |
January 2014 |
March 2014 |
May 7, 2012 |
February 16, 2015 |
February 16, 2015 |
- Forest Investigative Site 068
Dothan, Alabama, United States - Forest Investigative Site 005
Phoenix, Arizona, United States - Forest Investigative Site 055
Tucson, Arizona, United States - (and 103 more...)
|
|
| 14 |
NCT01592786 |
Completed
Has Results |
An Open-Label Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) |
- Autism Spectrum Disorder (ASD)
- Autism
- Autistic Disorder
- (and 4 more...)
|
- Drug: Memantine Hydrochloride (HCl)
|
Interventional
|
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Confirmed Social Responsiveness Scale (SRS) Responders
|
906 |
All |
6 Years to 12 Years (Child) |
NCT01592786 |
MEM-MD-91 |
|
June 2012 |
July 2013 |
August 2013 |
May 7, 2012 |
August 7, 2014 |
August 7, 2014 |
- Forest Investigative Site 068
Dothan, Alabama, United States - Forest Investigative Site 005
Phoenix, Arizona, United States - Forest Investigative Site 055
Tucson, Arizona, United States - (and 115 more...)
|
|
| 15 |
NCT01655173 |
Completed |
Cognitive Behavioural Therapy (CBT) and Recreational Activity for Autism Spectrum Disorders (ASD) |
- Asperger Syndrome
- Autistic Disorder
- Atypical Autism
|
- Behavioral: Cognitive behaviour therapy
- Behavioral: Recreational activity intervention
|
Interventional
|
Not Applicable |
- Karolinska Institutet
- Ministry of Health and Social Affairs, Sweden
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The Quality of Life Inventory (QOLI, Frisch et al. 1992)
- Sense of Coherence (SoC, Antonovsky 1993)
- The ten-item Rosenberg Self Esteem Scale (RSES, Rosenberg 1962)
- (and 6 more...)
|
68 |
All |
18 Years and older (Adult, Older Adult) |
NCT01655173 |
Dnr 52-6104 |
|
August 2005 |
September 2011 |
September 2011 |
August 1, 2012 |
June 18, 2014 |
|
- Northern Stockholm psychiatry, St. Göran hospital
Stockholm, Sweden
|
|
| 16 |
NCT01592747 |
Completed |
Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine |
- Autism Spectrum Disorder (ASD)
- Autism
- Autistic Disorder
- (and 5 more...)
|
- Drug: Memantine Hydrochloride (HCl)
- Drug: Placebo capsules
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The primary outcome measure in this study will be the proportion of patients meeting the criterion for Loss of Therapeutic Response (LTR) by the end of the study.
- Children's Communication Checklist-2 (CCC-2)
- Time to the first visit when a patient shows LTR following randomization to memantine or placebo (time to the first LTR)
|
480 |
All |
6 Years to 12 Years (Child) |
NCT01592747 |
MEM-MD-68 |
|
September 2012 |
September 2013 |
October 2013 |
May 7, 2012 |
November 4, 2013 |
|
- Forest Investigative Site 068
Dothan, Alabama, United States - Forest Investigative Site 005
Phoenix, Arizona, United States - Forest Investigative Site 055
Tucson, Arizona, United States - (and 128 more...)
|
|
| 17 |
NCT01031823 |
Unknown † |
Adolescent Social Skills Training Program |
- Asperger's Disorder
- High-functioning Autism
|
- Behavioral: Multi-Media Social Skills Training Program
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Social Fluency
- Loneliness Scale (Asher & Wheeler, 1985)
- Social Responsiveness Scale (SRS; Constantino, 2002)
- Strengths and Difficulties Questionnaire (SDQ; Goodman, 1997)
|
24 |
All |
13 Years to 17 Years (Child) |
NCT01031823 |
32300 |
ASST |
November 2009 |
December 2010 |
April 2011 |
December 15, 2009 |
January 26, 2011 |
|
- Penn State College of Medicine, Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
|
|
| 18 |
NCT00693953 |
Withdrawn |
Using the Digital EEG Spectral Analysis in Assessing Neuroelectrical Processing Abnormalities in Autism |
- Autistic Disorder
- Autism, Early Infantile
- Autism, Infantile
- Asperger Syndrome
|
|
Observational
|
|
- Yellen & Associates, Inc.
|
Other |
- Observational Model: Case Control
|
|
200 |
All |
5 Years to 25 Years (Child, Adult) |
NCT00693953 |
PA-06-278 |
|
January 2010 |
January 2011 |
December 2012 |
June 9, 2008 |
October 2, 2009 |
|
- Yellen & Associates, Inc.
Northridge, California, United States
|
|
| 19 |
NCT02250339 |
Active, not recruiting |
A Prospective Observational Study of Family-based Interventions for Children With Neuropsychiatric and/or Psychiatric Disorders |
- ADHD
- Asperger Syndrome
- Child Behavior Disorders
|
- Other: LAKU family program
- Other: Etä-LAKU family program
- Other: Family therapy
|
Observational
|
|
- Social Insurance Institution, Finland
- Paediatric Psychiatry Outpatient Clinic, TYKS Main Hospital
- University of Turku
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Child's Health Related Quality of Life questionnaire (HRQOL) - (KINDL-R)
- Multisource Assessment of Children's Socioemotional Competence Scale (MASCS)
- Parenting Self-Efficacy (PSE)
- (and 2 more...)
|
230 |
All |
5 Years to 12 Years (Child) |
NCT02250339 |
Perhe14
Kela |
|
December 2013 |
June 2018 |
December 2018 |
September 26, 2014 |
January 26, 2016 |
|
- Social Insurance Institution
Helsinki, Finland
|
|
| 20 |
NCT00619190 |
Completed
Has Results |
Study of Aripiprazole to Treat Children and Adolescents With Autism |
- Autistic Disorder
- Asperger Syndrome
- Autism Spectrum Disorder
|
|
Interventional
|
Phase 2 |
- University of North Carolina, Chapel Hill
- Bristol-Myers Squibb
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change From Baseline in Aberrant Behavior Checklist-Irritability at 12 Weeks
- Clinical Global Impressions Scale - Severity Score (CGI-S)
- Change From Baseline in the Aberrant Behavior Checklist -Lethargy/Social Withdrawal Subscale at 12 Weeks
|
30 |
All |
30 Months to 17 Years (Child) |
NCT00619190 |
04-1792 GCRC-2491 |
PAIRS |
January 2006 |
June 2012 |
June 2012 |
February 20, 2008 |
March 26, 2014 |
March 26, 2014 |
- University of North Carolina, Department of Psychiatry
Chapel Hill, North Carolina, United States
|
|
| 21 |
NCT00453180 |
Completed
Has Results |
A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders |
- Autistic Disorder
- Asperger Syndrome
- Child Development Disorders, Pervasive
|
- Drug: N-acetylcysteine
- Drug: Placebo
|
Interventional
|
Phase 2 |
- Indiana University School of Medicine
- National Alliance for Autism Research
- Indiana University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Clinical Global Impression - Severity
- Clinical Global Impression - Improvement
- Aberrant Behavior Checklist
- (and 3 more...)
|
31 |
All |
4 Years to 12 Years (Child) |
NCT00453180 |
0611-10 |
|
March 2007 |
August 2009 |
November 2009 |
March 28, 2007 |
June 14, 2017 |
June 14, 2017 |
- Riley Hospital, Riley Child and Adolescent Psychiatry Clinic
Indianapolis, Indiana, United States
|
|
| 22 |
NCT01247662 |
Completed |
Psychometric Studies of the Chinese Versions of the SRS, CAST, and AQ |
|
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
|
|
2460 |
All |
6 Years to 16 Years (Child) |
NCT01247662 |
201005041R |
|
January 2011 |
|
December 2011 |
November 24, 2010 |
November 15, 2012 |
|
- National Taiwan Univeristy Hospital
Taipei, Taiwan
|
|
| 23 |
NCT01983189 |
Terminated |
Transcranial Magnetic Stimulation for Evaluation and Treatment of Repetetive Behaviors in Autism |
- Autism
- Asperger Disorder
- Other Developmental Pervasive Disorder
|
- Procedure: transcranial magnetic stimulation
|
Interventional
|
Phase 2 |
- New York State Psychiatric Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- clinical improvement based on repetitive behavior scale.
- clinical improvement based on the social responsiveness scale.
|
10 |
All |
18 Years to 55 Years (Adult) |
NCT01983189 |
5594 |
|
November 2008 |
November 2010 |
November 2010 |
November 13, 2013 |
March 24, 2017 |
|
- New York State Psychiatric Institute, 1051 Riverside Drive
New York, New York, United States
|
|
| 24 |
NCT00965068 |
Completed |
Cholesterol in ASD: Characterization and Treatment |
- Autism
- Asperger Disorder
- PDD-NOS
|
|
Interventional
|
Phase 1
Phase 2 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
|
|
44 |
All |
4 Years to 12 Years (Child) |
NCT00965068 |
090203
09-CH-0203 |
|
July 28, 2009 |
|
November 14, 2013 |
August 25, 2009 |
October 6, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 25 |
NCT00198055 |
Completed |
A Study of Aripiprazole in Children and Adolescents With Aspergers and Pervasive Developmental Disorder. |
- Asperger's Disorder
- Pervasive Developmental Disorder
|
|
Interventional
|
Phase 2 |
- Indiana University School of Medicine
- Bristol-Myers Squibb
- Indiana University
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The Clinical Global Impression(CGI)Improvement Scale.
- The Irritability subscale of the Aberrant Behavior Checklist (ABC)
- The Clinical Global Impression Severity Scale.
- (and 2 more...)
|
25 |
All |
4 Years to 17 Years (Child) |
NCT00198055 |
0302-24 |
|
January 2005 |
September 2007 |
September 2007 |
September 20, 2005 |
June 4, 2014 |
|
- Riley Hospital, Riley Child and Adolescent Psychiatry Clinic
Indianapolis, Indiana, United States
|
|
| 26 |
NCT00496210 |
Completed |
Predictors of Caregiver Adaptation to Pervasive Developmental Disorders |
- Autism
- Asperger's Syndrome
- Rett's Disorder
|
|
Observational
|
|
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
324 |
All |
18 Years and older (Adult, Older Adult) |
NCT00496210 |
999907178
07-HG-N178 |
|
June 27, 2007 |
|
December 7, 2015 |
July 4, 2007 |
June 20, 2018 |
|
- National Human Genome Research Institute (NHGRI), 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 27 |
NCT01078844 |
Terminated
Has Results |
Memantine in Adult Autism Spectrum Disorder |
- Autism
- Asperger's Disorder
- Pervasive Developmental Disorder NOS
|
- Drug: memantine
- Drug: Placebo
|
Interventional
|
Not Applicable |
- Johns Hopkins University
- Forest Laboratories
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Clinical Global Impression-Scale(CGI-S)
|
4 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT01078844 |
NA_00015760 |
|
February 2010 |
July 2010 |
July 2010 |
March 2, 2010 |
July 26, 2017 |
July 26, 2017 |
- Johns Hopkins Bayview
Baltimore, Maryland, United States
|
|
| 28 |
NCT03170453 |
Recruiting |
Confirmatory Efficacy Trial of Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder |
- Autistic Disorder
- Autism Spectrum Disorder
- Asperger Syndrome
- Pervasive Developmental Disorder
|
- Behavioral: Cognitive Enhancement Therapy
- Behavioral: Enriched Supportive Therapy
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Neurocognition
- Change in Social cognition
- Change in Functional outcome
|
100 |
All |
16 Years to 45 Years (Child, Adult) |
NCT03170453 |
MH106450 |
PerspectivesII |
June 1, 2015 |
March 31, 2022 |
March 31, 2023 |
May 31, 2017 |
June 7, 2018 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
|
| 29 |
NCT00376194 |
Withdrawn |
Mercury Chelation to Treat Autism |
- Autism
- Asperger's Disorder
- Child Development Disorders, Pervasive
|
|
Interventional
|
Phase 2 |
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- Improvement in social reciprocity.
- Improvement in language skills, decrease in blood mercury levels.
|
0 |
All |
4 Years to 10 Years (Child) |
NCT00376194 |
060238
06-M-0238 |
|
September 2006 |
|
March 2007 |
September 14, 2006 |
September 18, 2013 |
|
- National Institute of Mental Health (NIMH), 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 30 |
NCT01160783 |
Active, not recruiting |
Genetic Contributions to Autism Spectrum Disorders |
- Autism Spectrum Disorder
- Autism
- Asperger's Syndrome
- Pervasive Developmental Disorder
|
|
Observational
|
|
- Boston Children’s Hospital
|
Other |
- Observational Model: Family-Based
- Time Perspective: Cross-Sectional
|
|
240 |
All |
18 Months and older (Child, Adult, Older Adult) |
NCT01160783 |
07-04-0136 |
|
April 2007 |
December 2020 |
February 2021 |
July 12, 2010 |
February 27, 2018 |
|
- Boston Children's Hospital
Boston, Massachusetts, United States
|
|
| 31 |
NCT00902798 |
Completed |
Cognitive Enhancement Therapy for Adult Autism Spectrum Disorder |
- Autistic Disorder
- Autism Spectrum Disorder
- Asperger's Syndrome
- Pervasive Developmental Disorder
|
- Behavioral: Cognitive Enhancement Therapy
- Behavioral: Enriched Supportive Therapy
|
Interventional
|
Not Applicable |
- University of Pittsburgh
- National Institute of Mental Health (NIMH)
- Autism Speaks
- (and 2 more...)
|
Other / NIH / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Neurocognition
- Social cognition
- Functional outcome
|
54 |
All |
16 Years to 45 Years (Child, Adult) |
NCT00902798 |
MH085851
R33MH085851
R21MH085851
AR100344
05381
2008NF-Autism
ARI2014 |
Perspectives |
August 2010 |
April 2016 |
June 2017 |
May 15, 2009 |
November 30, 2017 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
|
| 32 |
NCT01187784 |
Completed |
Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety |
- Autism Spectrum Disorder
- Autism
- Asperger Syndrome
- PDD-NOS
|
- Behavioral: Coping Cat cognitive-behavioral therapy for anxious youth
|
Interventional
|
Phase 1 |
- Alliant International University
- National Foundation for Autism Research
- Autism Society of America - San Diego Chapter
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Anxiety Disorders Interview Schedule - Child/Parent Version
- Multidimensional Anxiety Scale for Children
- Spence Children's Anxiety Scale (Child and Parent Versions)
|
22 |
All |
7 Years to 14 Years (Child) |
NCT01187784 |
McNallyKeehn |
|
May 2009 |
August 2010 |
August 2010 |
August 24, 2010 |
August 24, 2010 |
|
- Alliant International University
San Diego, California, United States
|
|
| 33 |
NCT01553240 |
Terminated
Has Results |
Neurocircuitry of Autism- fMRI and Transcranial Magnetic Stimulation Studies |
- Autism Spectrum Disorder
- Asperger Disorder
- Pervasive Developmental Disorder
|
- Device: TMS and functional MRI (Magstim)
|
Interventional
|
Not Applicable |
- New York State Psychiatric Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Repetitive Behavior Scale-revised
- Vineland Maladaptive Behavior Scale
|
8 |
All |
18 Years to 55 Years (Adult) |
NCT01553240 |
5438 |
|
June 2007 |
June 2010 |
June 2010 |
March 14, 2012 |
January 13, 2017 |
January 13, 2017 |
- New York state Psychiatric Institute
New York, New York, United States
|
|
| 34 |
NCT01086475 |
Completed
Has Results |
D-Cycloserine and Social Skills Training in Autism Spectrum Disorders |
- Autistic Disorder
- Asperger's Disorder
- Pervasive Developmental Disorder NOS
|
- Drug: D-cycloserine
- Drug: Placebo
|
Interventional
|
Phase 3 |
- Indiana University
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Social Responsiveness Scale (SRS) Change
- Social Responsiveness Scale (SRS) at Follow-Up
- Clinical Global Impressions Improvement Scale Responder Analysis
|
68 |
All |
5 Years to 11 Years (Child) |
NCT01086475 |
0906-09 |
|
March 2010 |
January 2014 |
January 2014 |
March 15, 2010 |
April 14, 2016 |
April 14, 2016 |
- Riley Hospital for Children
Indianapolis, Indiana, United States - Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
|
|
| 35 |
NCT00308074 |
Completed
Has Results |
An Open-Label Trial of Aripiprazole in Autism Spectrum Disorders |
- Autism
- Asperger's Disorder
- Pervasive Developmental Disorder
|
|
Interventional
|
Phase 2 |
- Cambridge Health Alliance
- Bristol-Myers Squibb
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Clinical Global Impressions-Improvement
- Aberrant Behavior Checklist-Irritability Subscale
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
- Brief Psychiatric Rating Scale for Children (BPRS-C)
|
14 |
All |
6 Years to 17 Years (Child) |
NCT00308074 |
CHA-IRB-0119/06/05 |
|
February 2006 |
December 2008 |
February 2009 |
March 29, 2006 |
February 15, 2017 |
January 2, 2017 |
- Cambridge Health Alliance
Medford, Massachusetts, United States
|
|
| 36 |
NCT02680015 |
Recruiting |
Understanding the Effects of Intervention on the Brain in Autism |
- Autism Spectrum Disorder
- Asperger Disorder
- PDD-NOS
- Autism
|
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Social Responsiveness Scale (SRS: Constantino, 2005)
- Test of Adolescent Social SKills (TASSK: Laugeson & Frankel, 2010)
|
400 |
All |
11 Years to 28 Years (Child, Adult) |
NCT02680015 |
HR 2020 |
|
August 2010 |
December 2025 |
December 2025 |
February 11, 2016 |
March 28, 2017 |
|
- Marquette University
Milwaukee, Wisconsin, United States
|
|
| 37 |
NCT00464477 |
Completed |
Advanced Grandparental Age as a Risk Factor for Autism |
- Autistic Disorder
- Pervasive Developmental Disorder
- Asperger Syndrome
- (and 2 more...)
|
|
Observational
|
|
- University of Mississippi Medical Center
|
Other |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
|
100 |
All |
Child, Adult, Older Adult |
NCT00464477 |
2007-0023 |
|
June 2007 |
|
October 2007 |
April 23, 2007 |
November 7, 2007 |
|
- University of Mississippi Medical Center
Jackson, Mississippi, United States
|
|
| 38 |
NCT01602016 |
Terminated
Has Results |
A Folinic Acid Intervention for Autism Spectrum Disorders |
- Autism Spectrum Disorder
- Autistic Disorder
- Autism
- (and 2 more...)
|
- Drug: Folinic Acid and placebo
- Drug: Folinic Acid
|
Interventional
|
Phase 2 |
- University of Arkansas
- Arkansas Children's Hospital Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Language Improvement
- Improved Stereotyped Behavior and Improved Social Skills
|
99 |
All |
3 Years to 14 Years (Child) |
NCT01602016 |
136002 |
|
May 2012 |
November 2015 |
November 2015 |
May 18, 2012 |
October 17, 2017 |
November 7, 2016 |
- Arkansas Children's Hospital Research Institute
Little Rock, Arkansas, United States
|
|
| 39 |
NCT01631851 |
Unknown † |
Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder |
- Autism
- Autism Spectrum Disorder (ASD
- Asperger's Disorder
- Pervasive Developmental Disorder (PDD-NOS)
|
- Behavioral: Cognitive-Behavioral Therapy (CBT) for Irritability
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
10 |
All |
9 Years to 16 Years (Child) |
NCT01631851 |
0102012121-B |
|
May 2011 |
December 2014 |
December 2014 |
June 29, 2012 |
July 8, 2014 |
|
- Yale Child Study Center
New Haven, Connecticut, United States
|
|
| 40 |
NCT03560453 |
Completed
New |
Facilitating Employment for Youth With Autism |
- Autism Spectrum Disorder
- Autism
- Asperger Syndrome
- (and 2 more...)
|
- Behavioral: Project SEARCH Plus ASD Supports
|
Interventional
|
Not Applicable |
- Virginia Commonwealth University
- National Institute on Disability, Independent Living, and Rehabilitation Research
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Employment Outcomes Survey
- Support Intensity Scale (SIS; Thompson, et al., 2004)
- Social Responsiveness Scale, Second Edition (Constantino & Gruber, 2012)
- (and 2 more...)
|
162 |
All |
18 Years to 22 Years (Adult) |
NCT03560453 |
HM15031
NIDILRRDRRP13-16 |
|
August 1, 2013 |
March 15, 2018 |
March 15, 2018 |
June 18, 2018 |
June 18, 2018 |
|
|
|
| 41 |
NCT01808066 |
Completed
Has Results |
GroundsKeeper: A Qualitative Study of Applied Game-based Interactives in Special Education Programs |
- Attention Deficit Hyperactivity Disorder
- Autism Spectrum Disorder
- Pervasive Developmental Disorder
- Asperger's Disorder
|
|
Interventional
|
Not Applicable |
- CogCubed, Corp
- Ohio University
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Participants With an Increase/Improvement in Focusing
- Pre Interview With Participants to Qualitatively Identify Interest and Motivation
|
21 |
All |
5 Years to 12 Years (Child) |
NCT01808066 |
12X226 |
|
January 2013 |
May 2013 |
May 2013 |
March 11, 2013 |
February 23, 2018 |
September 9, 2014 |
- Ohio University
Athens, Ohio, United States
|
|
| 42 |
NCT00844753 |
Completed
Has Results |
Atomoxetine, Placebo and Parent Management Training in Autism |
- Autism
- Pervasive Development Disorder
- Asperger's Disorder
- Attention Deficit Hyperactivity Disorder
|
- Drug: atomoxetine
- Drug: Placebo
- Behavioral: Parent Management Training
|
Interventional
|
Phase 4 |
- University of Rochester
- University of Pittsburgh
- Ohio State University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Percentage of Participants Who Were Attention Deficit Hyperactivity Disorder (ADHD) Respondents
- Percentage of Participants Who Were Autism Spectrum Disorder Respondents
|
128 |
All |
5 Years to 14 Years (Child) |
NCT00844753 |
1R01MH079082-01A2 |
Strattera |
October 2008 |
April 2014 |
April 2014 |
February 16, 2009 |
February 4, 2016 |
February 4, 2016 |
- University of Rochester Medical Center
Rochester, New York, United States - Ohio State University
Columbus, Ohio, United States - University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States
|
|
| 43 |
NCT01031407 |
Recruiting |
Cognitive Neuroscience of Autism Spectrum Disorders |
- Asperger's Disorder
- Mental Retardation
- Children
- (and 2 more...)
|
|
Observational
|
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
- Group differences in brain structure, brain function, and cognitive functions, as well as their genetic associations.
|
1600 |
All |
5 Years to 89 Years (Child, Adult, Older Adult) |
NCT01031407 |
100027
10-M-0027 |
|
November 19, 2009 |
|
|
December 14, 2009 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 44 |
NCT00261508 |
Completed |
A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Children With Autistic Disorder and Other Pervasive Developmental Disorders (PDD) |
- DCild Development Disorders, Pervasive
- Autistic Disorder
- Developmental Disabilities
- (and 2 more...)
|
|
Interventional
|
Phase 3 |
- Janssen-Ortho Inc., Canada
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- Change in the Irritability Subscale of the Aberrant Behavior Checklist (ABC) and other ABC subscales at end of treatment compared with baseline
- Change from baseline to end of treatment in Nisonger Child Behavior Rating Form (N-CBRF), Visual Analogue Scale (VAS), and Clinical Global Impression (CGI); incidence of adverse events throughout study.
|
80 |
All |
5 Years to 12 Years (Child) |
NCT00261508 |
CR006106 |
|
August 1999 |
|
December 2001 |
December 5, 2005 |
January 24, 2011 |
|
|
|
| 45 |
NCT02769949 |
Recruiting |
Pediatric Patients With Metabolic or Other Genetic Disorders |
- Genetic Disorder
- Asperger Disorder
- Autism Spectrum Disorder
- (and 2 more...)
|
|
Observational
|
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Other
|
- Recruit Patients with Suspected or Siagnosed genetic diseases
|
5000 |
All |
Child, Adult, Older Adult |
NCT02769949 |
160103
16-CH-0103 |
|
May 11, 2016 |
December 31, 2036 |
December 31, 2036 |
May 12, 2016 |
April 25, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
| 46 |
NCT01565629 |
Completed |
Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders |
- Autism
- Asperger's Syndrome
- Generalized Anxiety Disorder
- (and 3 more...)
|
- Behavioral: Computer assisted cognitive behavioral therapy.
|
Interventional
|
Not Applicable |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pediatric Anxiety Rating Scale
- Anxiety Disorders Interview Schedule: Parent and Child Versions
- Clinical Global Impression - Severity Scale
|
40 |
All |
7 Years to 12 Years (Child) |
NCT01565629 |
CCAL-2012 |
CCAL |
February 2012 |
October 2016 |
October 2016 |
March 28, 2012 |
October 26, 2017 |
|
- University of South Florida
Saint Petersburg, Florida, United States
|
|
| 47 |
NCT01178385 |
Completed
Has Results |
Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders |
- Autism
- Asperger's Syndrome
- Generalized Anxiety Disorder
- (and 3 more...)
|
- Behavioral: Cognitive-behavioral therapy
- Behavioral: Treatment as Usual
|
Interventional
|
Phase 2
Phase 3 |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pediatric Anxiety Rating Scale (Measures the Severity of Anxiety Symptoms)
- Anxiety Disorders Interview Schedule Highest Anxiety Clincian Severity Rating (Measures the Severity of the Child's Anxiety Symptoms)
- Clinical Global Impression - Severity Scale (This Scale Measures the Severity of the Child's Anxiety Symptoms).
|
45 |
All |
7 Years to 11 Years (Child) |
NCT01178385 |
ACH-2010 |
|
April 2010 |
December 2012 |
December 2012 |
August 10, 2010 |
April 2, 2013 |
April 2, 2013 |
- Rothman Center for Neuropsychiatry, University of South Florida
St. Petersburg, Florida, United States
|
|
| 48 |
NCT02199925 |
Unknown † |
An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum |
- Autism
- Autistic Disorder
- Asperger's Disorder
- (and 2 more...)
|
|
Interventional
|
Phase 4 |
- Isaac Melamed
- Bio Products Laboratory
- IMMUNOe Research Centers
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary objective is to assess the efficacy of Gammaplex as an immunomodulatory therapy in autistic children with evidence of immune dysfunction.
- The modulatory effect of IVIG on neuroinflammation will be assessed by laboratory measurements which we believe are indicative of immune dysregulation.
|
30 |
All |
4 Years to 12 Years (Child) |
NCT02199925 |
GMXAUT01 |
|
June 2013 |
April 2015 |
July 2015 |
July 25, 2014 |
April 16, 2015 |
|
- IMMUNOe International Research Centers
Centennial, Colorado, United States
|
|
| 49 |
NCT01919970 |
Completed |
Exposure-Focused Family-Based CBT for Youth With ASD and Comorbid Anxiety |
- Autism
- Asperger's Syndrome
- Pervasive Developmental Disorder Not Otherwise Specified
- (and 5 more...)
|
- Other: Cognitive Behavioral Therapy
- Other: Treatment as usual
|
Interventional
|
Not Applicable |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pediatric Anxiety Rating Scale
- Clinical Global Impression - Severity Scale
|
50 |
All |
6 Years to 12 Years (Child) |
NCT01919970 |
ASD-FET 2013 |
|
August 2013 |
August 2016 |
August 2017 |
August 9, 2013 |
October 26, 2017 |
|
- Rothman Center for Neuropsychiatry
Saint Petersburg, Florida, United States
|
|
| 50 |
NCT01563003 |
Completed
Has Results |
Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism |
- Autism
- Asperger's Syndrome
- Pervasive Developmental Disorder Not Otherwise Specified
- (and 4 more...)
|
- Other: Cognitive Behavioral Therapy
- Other: Treatment as usual
|
Interventional
|
Not Applicable |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pediatric Anxiety Rating Scale
- Anxiety Disorders Interview Schedule Clinical Severity Rating
- Clinical Global Impression - Severity Scale
|
31 |
All |
11 Years to 16 Years (Child) |
NCT01563003 |
AASD-2012 |
|
June 2011 |
April 2015 |
April 2015 |
March 26, 2012 |
April 17, 2015 |
April 17, 2015 |
- Rothman Center for Neuropsychiatry
St. Petersburg, Florida, United States
|
|
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