| 1 |
NCT03020186 |
Recruiting |
Effects of Green-MED Diet Via the Gut-fat-brain Axis |
- Abdominal Obesity Metabolic Syndrome
|
- Other: Physical activity
- Other: Physical activity+ MED diet
- Other: Physical activity+green MED diet
|
Interventional |
Not Applicable |
- Ben-Gurion University of the Negev
- Harvard School of Public Health
- University of Leipzig
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Abdominal fat
- Hepatic fat
- Obesity
- (and 15 more...)
|
270 |
All |
30 Years and older (Adult, Senior) |
NCT03020186 |
BGU |
DIRECT-PLUS |
November 2016 |
October 2018 |
October 2020 |
January 13, 2017 |
January 13, 2017 |
|
- Nuclear research center Negev
Dimona, Israel
|
| 2 |
NCT02954588 |
Recruiting |
Effect of Pyridoxamine Supplementation on Vascular Function and Insulin Sensitivity |
- Abdominal Obesity Metabolic Syndrome
|
- Dietary Supplement: Pyridoxamine
- Dietary Supplement: Placebo
|
Interventional |
Not Applicable |
- Maastricht University Medical Center
- Top Institute Food and Nutrition
- Center for Translational Molecular Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Insulin sensitivity
- Microvascular function
|
120 |
All |
18 Years to 65 Years (Adult) |
NCT02954588 |
NL51023.068.16 |
|
October 2016 |
October 2018 |
|
November 3, 2016 |
November 3, 2016 |
|
- Maastricht University Medical Center
Maastricht, Netherlands
|
| 3 |
NCT02283242 |
Completed |
Galantamine Effects in Patients With Metabolic Syndrome |
- Abdominal Obesity Metabolic Syndrome
|
- Drug: Galantamine
- Drug: Placebo (for galantamine)
|
Interventional |
Phase 4 |
- University of Sao Paulo
- University of Nove de Julho
- Feinstein Institute for Medical Research
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Composite measure of cytokines and adipokines levels, to include IL-1, IL-6, TNF alpha, leptin and adiponectin
- Glucose, triglycerides and high density lipoprotein cholesterol levels
- Insulin levels
- (and 4 more...)
|
60 |
All |
18 Years to 59 Years (Adult) |
NCT02283242 |
CAAE:27386114.9.0000.0068
2013/22250-9 |
GALANTA-MS |
March 2014 |
March 2015 |
February 2017 |
November 5, 2014 |
February 15, 2017 |
|
- University of São Paulo, Heart Institute, Medical School
São Paulo, Brazil
|
| 4 |
NCT01872182 |
Terminated |
Efficacy and Safety Study of ALS-L1023 in Patients With Abdominal Obesity of Metabolic Syndrome |
- Abdominal Obesity Metabolic Syndrome
|
- Drug: ALS-L1023
- Drug: placebo
|
Interventional |
Phase 3 |
- Hanmi Pharmaceutical Company Limited
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Percent change from baseline to 12 week in visceral fat area measured by CT
- improvement of metabolic profile
- change of insulin resistance
- change of BMI
|
200 |
All |
20 Years to 64 Years (Adult) |
NCT01872182 |
HM-MELS-301 |
|
May 2013 |
January 2015 |
January 2015 |
June 7, 2013 |
October 11, 2016 |
|
- 5 Institutions
Seoul, Korea, Republic of
|
| 5 |
NCT02626741 |
Unknown † |
Effect of a Meal Replacement on Weight Loss Obesity Patients With Metabolic Syndrome |
- Abdominal Obesity-Metabolic Syndrome
|
- Dietary Supplement: meal replacement group
- Behavioral: control group
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Participants with weight loss unit in kilograms
- Participants with waist circumference change in centimeters
- Participants with triglyceride change in mg/dl.
- Number of Patients With Grade 3 Through Grade 5 Adverse Events That Are Related to Study meal replacement, Graded According to NCI CTCAE Version 3.0
|
138 |
All |
18 Years and older (Adult, Senior) |
NCT02626741 |
647-2557-EC4 |
SlimWell |
February 2015 |
February 2016 |
April 2016 |
December 10, 2015 |
December 10, 2015 |
|
- Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, Thailand
|
| 6 |
NCT02480673 |
Unknown † |
EFFECT OF Salvia Hispanica l. (CHIA) IN THE BIOCHEMICAL METABOLIC SYNDROME COMPONENTS |
|
- Dietary Supplement: Chia
- Dietary Supplement: Oatmeal
- Behavioral: Normocaloric diet
|
Interventional |
Not Applicable |
- Instituto Mexicano del Seguro Social
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in serum glucose levels
- Variation in lipid profile
- Modification in insulin resistance
- (and 4 more...)
|
100 |
All |
18 Years to 50 Years (Adult) |
NCT02480673 |
R-2015-785-047 |
|
June 2015 |
December 2015 |
May 2016 |
June 24, 2015 |
June 26, 2015 |
|
- Instituto Mexicano Del Seguro Social Hospital de Especialidades, Centro Medico Nacional de Occidente Lic. Ignacio Garcia Tellez Unidad Medica de Alta Especialidad
Guadalajara, Jalisco, Mexico
|
| 7 |
NCT01577277 |
Completed |
OPUS School Meal Study - Cross Sectional Analyses From Baseline Investigations |
|
|
Observational |
|
- Arne Astrup
- Technical University of Denmark
- University of Aarhus
- (and 2 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Metabolic syndrome score
- Body composition
- Concentration Performance
- (and 21 more...)
|
834 |
All |
8 Years to 12 Years (Child) |
NCT01577277 |
D208 baseline
H-1-2010-124 |
|
May 2011 |
December 2011 |
December 2011 |
April 13, 2012 |
March 6, 2017 |
|
- Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen Copenhagen, Denmark
Copenhagen, Denmark
|
| 8 |
NCT01457794 |
Completed |
OPUS School Meal Study |
|
- Other: School meals based on the principles of the New Nordic Diet
|
Interventional |
Not Applicable |
- Arne Astrup
- Technical University of Denmark
- University of Aarhus
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Metabolic syndrome score
- Concentration Performance
- Early Cardiovascular Risk Markers
- (and 22 more...)
|
834 |
All |
8 Years to 11 Years (Child) |
NCT01457794 |
D208
H-1-2010-124 |
|
May 2011 |
June 2012 |
June 2012 |
October 24, 2011 |
March 6, 2017 |
|
- Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen
Copenhagen, Denmark
|
| 9 |
NCT02356952 |
Completed |
Effect of a Low Glycemic Index on Metabolic Syndrome |
|
- Behavioral: Mediterranean Diet
- Behavioral: Low Glycemic Index Diet
- Behavioral: Low Glycemic Index Mediterranean Diet
|
Interventional |
Not Applicable |
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from Baseline in MetS score at six months
- Change from Baseline in Serum Cholesterol at six months
- Change from Baseline in Serum HDL Cholesterol at six months
- (and 10 more...)
|
163 |
All |
30 Years to 89 Years (Adult, Senior) |
NCT02356952 |
Medidiet |
|
September 2014 |
June 2015 |
August 2015 |
February 6, 2015 |
July 26, 2016 |
|
- Laboratory of Epidemiology and Biostatistics-IRCCS Saverio de Bellis
Castellana Grotte, BA, Italy
|
| 10 |
NCT03310359 |
Recruiting |
Clinical Trial of Anti-oxidant Astaxanthin in Insulin-resistant Subjects |
|
- Dietary Supplement: Astaxanthin
- Other: Placebo
|
Interventional |
Phase 1 |
- University of California, San Diego
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Change in insulin sensitivity
- Change in lipid control
- Change in fasting glucose
|
34 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03310359 |
151542 |
Astaxanthin |
July 2016 |
April 2018 |
April 2018 |
October 16, 2017 |
October 16, 2017 |
|
- Altman Clinical and Translational Research Institute (ACTRI)
San Diego, California, United States
|
| 11 |
NCT02495961 |
Completed |
Study of Chronic Degenerative Diseases |
|
|
Observational |
|
- Asociación Científica Latina A.C.
- Universidad Autonoma del Estado de Mexico
- Ciprés Grupo Médico CGM SC
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Metabolic syndrome component detection
|
57 |
All |
6 Years to 12 Years (Child) |
NCT02495961 |
2014-01 |
|
June 2015 |
January 2016 |
February 2016 |
July 13, 2015 |
February 17, 2016 |
|
- Asociación Científica Latina A.C.
Toluca, State of Mexico, Mexico
|
| 12 |
NCT02042274 |
Completed
Has Results |
Efficacy Study Regarding the Beneficial Effects of Omega-3 Fatty Acids on Cardiometabolic Health |
|
- Dietary Supplement: Fish oil supplement
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Blood Triglyceride
- Blood Glucose
|
12 |
Male |
18 Years to 30 Years (Adult) |
NCT02042274 |
Fish Oil and Health Study
12JL006 |
FOHS |
October 2012 |
March 2013 |
February 2015 |
January 22, 2014 |
April 5, 2017 |
April 5, 2017 |
- University of Guelph - Human Nutraceutical Research Unit
Guelph, Ontario, Canada
|
| 13 |
NCT02288572 |
Completed |
Probiotic Bacteria in Prevention of the Metabolic Syndrome |
|
- Dietary Supplement: Lactobacillus plantarum PCS 26
- Dietary Supplement: Placebo
|
Interventional |
Phase 2 |
- University Maribor
- Slovenian Research Agency
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Basic Science
|
- Serum lipids concentrations after daily consumption of dietary supplement in patients with the metabolic syndrome
- Measures of body composition after daily consumption of dietary supplement in patients with the metabolic syndrome
|
16 |
All |
21 Years to 85 Years (Adult, Senior) |
NCT02288572 |
MGPS001 |
|
May 2013 |
March 2014 |
May 2014 |
November 11, 2014 |
November 11, 2014 |
|
|
| 14 |
NCT00956189 |
Completed |
Identification and Treatment Response Prediction of Antipsychotic-Related Metabolic Syndrome |
|
- Drug: amisulpride
- Drug: aripiprazole
|
Interventional |
Not Applicable |
- National Taiwan University Hospital
- Yu-Li Veterans Hospital
- Yu-Li Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Metabolic profile
- Clinical efficacy
|
132 |
All |
20 Years and older (Adult, Senior) |
NCT00956189 |
200812110M |
|
November 2009 |
August 2012 |
October 2012 |
August 11, 2009 |
January 3, 2013 |
|
- Yu-Li Hospital
Yu-Li, Hualien County, Taiwan - Yu-Li Veterans Hospital
Yu-Li, Hualien County, Taiwan - National Taiwan University Hospital
Taipei, Taiwan
|
| 15 |
NCT01548300 |
Completed |
Environmental Triggers Of Cardiometabolic Disease |
|
|
Observational |
|
- Sanjay Rajagopalan
- University of Michigan
- Peking Union Medical College
- (and 2 more...)
|
Other / NIH |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
- Death
- Inflammation markers
|
66 |
All |
35 Years to 65 Years (Adult) |
NCT01548300 |
HP-00059994
R01ES019616 |
AIRCMD |
February 2011 |
December 2014 |
December 2014 |
March 8, 2012 |
February 8, 2018 |
|
- University of Michigan
Ann Arbor, Michigan, United States - The Ohio State University
Columbus, Ohio, United States - Peking Union Medical College
Peking, Beijing, China
|
| 16 |
NCT01173380 |
Completed |
Soy Nut Study on Markers of Health |
|
- Other: Soy nuts
- Other: Matched food
|
Interventional |
Not Applicable |
- University of California, Davis
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improve lipid profile
- Increase endothelial function
- Attenuate glycemic responses
- (and 2 more...)
|
18 |
All |
21 Years and older (Adult, Senior) |
NCT01173380 |
200715715-4 |
|
August 2010 |
September 2012 |
September 2012 |
August 2, 2010 |
May 30, 2017 |
|
- Ragle Human Nutrition Center
Davis, California, United States
|
| 17 |
NCT02001376 |
Unknown † |
A Health Promotion Project for Workers at National Taiwan University Hospital |
- Abdominal Obesity Metabolic Syndrome
- Subjects With Poor Fitness Status.
|
- Other: Intensive exercise
- Other: Home exercise
- Other: Control group live as usual
|
Interventional |
Not Applicable |
- National Taiwan University Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- All improve fitness status
|
240 |
All |
20 Years to 60 Years (Adult) |
NCT02001376 |
201007040R |
|
April 2011 |
December 2014 |
December 2014 |
December 4, 2013 |
December 4, 2013 |
|
- Physical Therapy Center, National Taiwan University Hospital
Taipei, Taiwan
|
| 18 |
NCT00695825 |
Unknown † |
Effects the Glycemic Index on Metabolic Risk Markers |
|
- Dietary Supplement: Low GI+high GI
- Dietary Supplement: High GI+low GI
|
Interventional |
Not Applicable |
- Maastricht University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- inflammation markers
- glucose response
|
30 |
Male |
18 Years to 65 Years (Adult) |
NCT00695825 |
073101 |
|
February 2008 |
November 2008 |
December 2008 |
June 12, 2008 |
December 12, 2008 |
|
- University Maastricht
Maastricht, Netherlands
|
| 19 |
NCT00561626 |
Completed |
Effects of High-fat and Low-fat Diet on the Gut |
|
- Dietary Supplement: high fat diet followed by low fat diet
- Dietary Supplement: low fat diet followed by high fat diet
|
Interventional |
Not Applicable |
- Maastricht University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- potential early biomarkers in plasma
- gene expression in the small intestine and in peripheral blood mononuclear cells (PBMC)
- gut permeability
|
10 |
Male |
18 Years to 65 Years (Adult) |
NCT00561626 |
07-3-088 |
|
January 2008 |
October 2008 |
December 2008 |
November 21, 2007 |
February 24, 2017 |
|
- Maastricht University, Department of Human Biology
Maastricht, Netherlands
|
| 20 |
NCT00558740 |
Completed |
Effects of Dietary Proteins on Hepatic Lipid Metabolism |
|
- Other: high protein intake
|
Observational |
|
- University of Lausanne
- University Hospital Inselspital, Berne
|
Other |
- Time Perspective: Prospective
|
- Whole body lipid oxidation Medium chain triglyceride oxidation Long chain triglyceride oxidation VLDL-triglyceride kinetics Hepatic de novo lipogenesis whole body glucose and glycerol turnover
- Energy expenditure Glucagon/insulin ratio Plasma growth hormone concentrations gene expression in subcutaneous adipose tissue Plasma ketone bodies concentrations
|
22 |
Male |
18 Years to 30 Years (Adult) |
NCT00558740 |
protocol 66/07/CE/FBM
SNF 310000-109737 |
|
January 2009 |
April 2009 |
April 2009 |
November 15, 2007 |
February 10, 2012 |
|
- Centre Hospitalier Universitaire Vaudois
Lausanne, Vaud, Switzerland
|
| 21 |
NCT00515021 |
Unknown † |
Diurnal Variation of Plasminogen Activator Inhibitor-1 |
|
- Drug: Eplerenone (Morning vs. evening drug regimen)
|
Interventional |
Phase 4 |
- Vanderbilt University
- National Center for Research Resources (NCRR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Supportive Care
|
- Evidence of improved fibrinolytic balance
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT00515021 |
070183 |
|
April 2007 |
April 2010 |
April 2010 |
August 13, 2007 |
January 29, 2009 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
| 22 |
NCT00147264 |
Completed |
Telmisartan-Induced Reduction in Intra-Myocellular Lipids Trial |
|
- Drug: Telmisartan (Micardis®) vs. Placebo
- Behavioral: Low-Glycemic Index Diet vs. Control Diet
|
Interventional |
Phase 3 |
- McMaster University
- Boehringer Ingelheim
- Canadian Institutes of Health Research (CIHR)
- (and 2 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- (for both interventions): change in IMCL content in the soleus muscle as assessed by 1H-MRI Spectroscopy at baseline and 6 months
- Change in intra-hepatocellular lipid storage as assessed by 1H-MRI Spectroscopy
- Change in insulin sensitivity as determined by HOMA index
- (and 16 more...)
|
120 |
All |
30 Years to 70 Years (Adult, Senior) |
NCT00147264 |
502.433
BI Pharmaceuticals - 502.433
CIHR - 116099 |
|
April 2004 |
January 2006 |
November 2006 |
September 7, 2005 |
December 14, 2016 |
|
- Hamilton Health Sciences - Cardiovascular Obesity Research and Management Center
Hamilton, Ontario, Canada
|
| 23 |
NCT02969720 |
Not yet recruiting |
Therapeutic Efficacy of Phytosterols on Metabolic Syndrome |
|
- Dietary Supplement: Phytosterols
- Dietary Supplement: Titanium Dioxide
|
Interventional |
Phase 3 |
- Universidad Los Andes, Chile
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Difference of proportion between study groups in the proportion of metabolic syndrome from baseline and the last visit (180 days).
|
200 |
All |
18 Years to 65 Years (Adult) |
NCT02969720 |
FESIME-016 |
FESIME |
March 2017 |
October 2017 |
December 2017 |
November 21, 2016 |
November 21, 2016 |
|
|
| 24 |
NCT02958579 |
Recruiting |
a Population Based Study on Metabolic Syndrome Complications, and Mortality |
|
- Other: No intervention will be done. Participants are on standard care and the treatments will be recorded because of observational nature of this study.
|
Observational |
|
- Tehran University of Medical Sciences
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- incidence of CVD
- incidence of microvascular complications of T2D (diabetic retinopathy, diabetic neuropathy, diabetic kidney disease), and diabetic foot
- incidence of non-alcoholic fatty liver disease (NAFLD)
- (and 3 more...)
|
10000 |
All |
40 Years to 70 Years (Adult, Senior) |
NCT02958579 |
95-03-191-33053
957275 |
MetSCoM |
January 2005 |
January 2017 |
January 2020 |
November 8, 2016 |
November 8, 2016 |
|
- Tehran University of Medical Sciences
Tehran, Iran, Islamic Republic of
|
| 25 |
NCT02949622 |
Completed |
Multimodal Intervention Program for Patients With Metabolic Syndrome |
|
- Behavioral: Multimodal intervention program
- Other: Lifestyle counseling
|
Interventional |
Not Applicable |
- Universidad de Granada
- University Hospital Virgen de las Nieves
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Weight
- Waist circumference
- Blood pressure
- (and 8 more...)
|
136 |
All |
25 Years to 65 Years (Adult) |
NCT02949622 |
CAPES 5566-10-0 |
PROMETS |
February 2013 |
September 2016 |
October 2016 |
October 31, 2016 |
June 21, 2017 |
|
- Jaqueline Garcia da Silva
Granada, Spain
|
| 26 |
NCT02936687 |
Recruiting |
Mechanisms of Cerebrovascular Control |
|
- Drug: NOS Inhibition
- Drug: ET-1 Inhibition
- Drug: Placebo
- (and 3 more...)
|
Interventional |
Phase 1 |
- University of Wisconsin, Madison
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in cerebrovascular blood flow in response to NOS inhibition.
- Change in cerebrovascular blood flow in response to ET-1 inhibition.
|
60 |
All |
18 Years to 45 Years (Adult) |
NCT02936687 |
2015-0197 |
|
January 31, 2017 |
December 2018 |
December 2018 |
October 18, 2016 |
August 18, 2017 |
|
- University of Wisconsin, Madison
Madison, Wisconsin, United States
|
| 27 |
NCT02918422 |
Active, not recruiting |
Controlled Clinical Study to Determine Novel Health Benefits of Cheese Consumption |
|
- Other: Nutritional and Dietary Manipulation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change in Plasma Fatty Acid Composition and Lipoprotein Analysis
- Change in Body Composition as Assessed by DEXA and MRI
- Change in Blood-based Inflammation Markers
- Change in Blood Metabolite Profiles
|
30 |
All |
21 Years to 65 Years (Adult) |
NCT02918422 |
GRT00036921
60047084 |
|
September 2015 |
April 2018 |
September 2018 |
September 29, 2016 |
April 5, 2018 |
|
- Physical Activity and Education Services - PAES
Columbus, Ohio, United States
|
| 28 |
NCT02783703 |
Recruiting |
Evaluation of MCT in a Mixed Racial Population of Patients With Metabolic Syndrome: a Feasibility Study |
|
- Dietary Supplement: Medium chain triglycerides (MCT)
|
Interventional |
Not Applicable |
- Boston Medical Center
- Boston University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change from baseline in insulin sensitivity to 6 weeks as measured by intravenous glucose tolerance test
- Change from baseline to 6 weeks in resting energy expenditure (kilocalories)
- Change from baseline to 6 weeks in body composition (% fat, muscle and bone)
- (and 2 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT02783703 |
H-35267 |
|
April 28, 2017 |
June 2018 |
June 2018 |
May 26, 2016 |
January 4, 2018 |
|
- Boston Medical Center
Boston, Massachusetts, United States
|
| 29 |
NCT02479113 |
Recruiting |
Maternal Hypertriglyceridaemia Study |
|
- Procedure: Blood sampling
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Relationship between maternal pregravid BMI/ Tg/NEFA/HOMA2%-S and BW/neonatal adiposity
- Neonatal fatty liver on ultrasound/fetal insulin secretion/fetal insulin resistance
- Neonatal hypoglycaemia in GDM offspring weighing > 3.5 kg
- (and 8 more...)
|
400 |
Female |
18 Years and older (Adult, Senior) |
NCT02479113 |
201401-0691 |
|
March 2014 |
December 2018 |
December 2024 |
June 24, 2015 |
November 1, 2016 |
|
- University of Malaya
Kuala Lumpur, Malaysia
|
| 30 |
NCT02696304 |
Unknown † |
The Metabolic Syndrome Among Leukemia Survivors: Physiopathological Analysis |
|
- Other: Adipose tissu repartition
- Other: Visceral and liver adipose tissue repartition
- Other: Preadipocyte quantification and adipose tissue inflamation
- Other: Inflamation blood markers quantification
|
Interventional |
Not Applicable |
- Assistance Publique Hopitaux De Marseille
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Percent of fat mass (Biphotonic absorptiometry)
- Evaluation of the amount of intra liver and pancreatic triglycerides (%) (proton spectroscopy, expressed as percent related to liver or pancreatic water content)
- Fibrosis and inflammation analyses of the adipose tissu : fibrosis and inflammation gene expression analyses by RQ-PCR
- Preadipocytes quantification in the adipose tissue by immunohistochemistery, expressed as percent of stroma vascular fraction of the adipose tissue
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT02696304 |
2015-A00170-49
2015-05 |
LEAMS |
May 2015 |
May 2016 |
December 2016 |
March 2, 2016 |
March 2, 2016 |
|
- Assistance Publique Hopitaux de Marseille
Marseille, France
|
| 31 |
NCT02606812 |
Not yet recruiting |
Effect of Food Consumption on microRNA Related to Metabolic Syndrome |
|
- Dietary Supplement: Traditional-food
|
Interventional |
Not Applicable |
- Universidad Juárez Autónoma de Tabasco
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
|
- Changes on biochemical parameters and selected miRNA
|
50 |
All |
20 Years to 22 Years (Adult) |
NCT02606812 |
UniversidadJAT |
EFCMRNAMS |
March 2017 |
April 2017 |
April 2018 |
November 17, 2015 |
October 26, 2016 |
|
|
| 32 |
NCT02605655 |
Completed |
Clinical Trial of Chinese Formula AMP-1915 on Metabolic Syndrome |
|
- Drug: AMP-1915
- Other: Placebo
|
Interventional |
Early Phase 1 |
- Shanghai University of Traditional Chinese Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Fasting blood glucose (FBG)
- Plasma lipid levels
- Plasma Insulin concentration
- (and 2 more...)
|
60 |
All |
40 Years to 65 Years (Adult) |
NCT02605655 |
ShanghaiUTCM-01 |
|
June 2014 |
December 2014 |
April 2015 |
November 16, 2015 |
January 7, 2016 |
|
|
| 33 |
NCT02542176 |
Completed |
Effects of a Standardized Freeze-dried Grape Powder on High Density Lipoprotein (HDL) Function in Metabolic Syndrome |
|
- Other: Freeze-dried Whole Grape Powder
- Other: Grape Powder Placebo
|
Interventional |
Not Applicable |
- University of Connecticut
- California Table Grape Commission
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Fasted HDL-cholesterol
- Fasted apolipoprotein B-depleted serum cholesterol efflux capacity
- Postprandial HDL anti-inflammatory activity
- Postprandial HDL antioxidant activity
|
20 |
All |
30 Years to 70 Years (Adult, Senior) |
NCT02542176 |
150888 |
|
October 2015 |
March 2018 |
March 2018 |
September 4, 2015 |
March 23, 2018 |
|
- University of Connecticut
Storrs, Connecticut, United States
|
| 34 |
NCT02531334 |
Active, not recruiting |
Effects of TA-65, a Telomerase Activator on Metabolic Syndrome |
|
- Dietary Supplement: TA-65
|
Interventional |
Not Applicable |
- University of Connecticut
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Plasma insulin
- Plasma HDL cholesterol
|
40 |
All |
32 Years to 70 Years (Adult, Senior) |
NCT02531334 |
H14-278 |
|
August 2015 |
December 2017 |
June 2018 |
August 24, 2015 |
February 8, 2018 |
|
- University of Connecticut
Storrs, Connecticut, United States
|
| 35 |
NCT02407522 |
Completed |
The Improvements of Dietary Supplement of Black Rice on Metabolic Syndrome |
|
- Dietary Supplement: Black rice
- Other: follow-up
|
Interventional |
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- reversal rate of metabolic syndrome
- proportion of Bacteroides
- proportion of Bifidobacterium
|
101 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT02407522 |
SunYat-senU001 |
IDSBRMS |
June 2014 |
December 2014 |
December 2014 |
April 3, 2015 |
April 3, 2015 |
|
|
| 36 |
NCT01849068 |
Completed
Has Results |
Effects of Selective Inhibition of Cholesterol Absorption With Ezetimibe on Intestinal Cholesterol Homeostasis in Dyslipidemic Men With Insulin-resistance - a Pilot Study |
|
- Drug: Ezetimibe
- Drug: Placebo
|
Interventional |
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Intestinal mRNA Expression Levels of LDL Receptor Between the Two 12-week Interventions
- Change in Intestinal mRNA Expression Levels of SREBP-2, NPC1L1, ABCG5/8, PCSK9 and HMG CoA Reductase Between the Two 12-week Interventions
- Change in Intestinal Protein Levels of LDL Receptor Between the Two 12-week Interventions
- Change in Protein Levels of SREBP-2, NPC1L1, ABCG5/8, PCSK9 and HMG CoA Reductase Between the Two 12-week Interventions
|
20 |
Male |
18 Years to 60 Years (Adult) |
NCT01849068 |
INAF-B13-04-1195 |
EZEmRNA |
June 2013 |
June 2015 |
February 2016 |
May 8, 2013 |
April 12, 2016 |
April 12, 2016 |
- Laval University
Quebec, Canada
|
| 37 |
NCT01944124 |
Completed |
Exercise and Technology to Reduce Risk in a Rural Population With Metabolic Syndrome |
|
- Behavioral: Mobile Health
- Behavioral: Exercise Prescription
|
Interventional |
Not Applicable |
- Lawson Health Research Institute
- Canadian Institutes of Health Research (CIHR)
- Heart and Stroke Foundation of Canada
- Canadian Diabetes Association
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Prevention
|
|
149 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01944124 |
15828 |
|
November 2009 |
March 2011 |
December 2011 |
September 17, 2013 |
October 22, 2013 |
|
- Gateway Rural Health Research Institute
Seaforth, Ontario, Canada
|
| 38 |
NCT01829945 |
Completed |
Study of the Relationships Between Apolipoprotein B-48 Kinetics and Expression of Genes That Regulate Intestinal Lipid Metabolism in Men With the Metabolic Syndrome (SMB48) |
|
|
Observational |
|
- Laval University
- Canadian Institutes of Health Research (CIHR)
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Change in TRL apolipoproteinB-48 production rate.
- Changes in duodenal expression of genes that regulate intestinal lipid absorption.
- Change in duodenal expression of genes that regulate intestinal lipid synthesis.
- Change in synthesis of apolipoproteinB-48 containing lipoproteins (Microsomal triglyceride transfer protein (MTP), apolipoproteinB-48).
|
30 |
Male |
18 Years to 60 Years (Adult) |
NCT01829945 |
INAF-129-05-02 |
|
October 2009 |
February 2010 |
February 2011 |
April 11, 2013 |
April 11, 2013 |
|
- Institute of Nutrition and Functional Foods (INAF)
Quebec, Canada
|
| 39 |
NCT01694056 |
Completed |
Soy Protein Intake and the Metabolic Syndrome |
|
- Other: Soy protein diet
- Other: Control diet
|
Interventional |
Not Applicable |
- Wageningen University
- Alpro Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Prevention
|
- Insulin sensitivity
- Adipose tissue gene expression
- Blood lipids
- (and 3 more...)
|
15 |
Female |
45 Years to 70 Years (Adult, Senior) |
NCT01694056 |
NL39991.081.12 |
SOY |
September 2012 |
December 2012 |
December 2012 |
September 26, 2012 |
January 4, 2013 |
|
- Wageningen University
Wageningen, Netherlands
|
| 40 |
NCT01022411 |
Completed |
Brown Rice Intervention on Metabolic Syndrome (BRIMS) |
|
- Dietary Supplement: Brown rice/White rice
|
Interventional |
Phase 2
Phase 3 |
- Chinese Academy of Sciences
- Harvard School of Public Health
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- fasting glucose
- Insulin
- total cholesterol
- (and 5 more...)
|
202 |
All |
35 Years to 60 Years (Adult) |
NCT01022411 |
KSCX1-YW-02-BR |
BRIMS |
October 2009 |
July 2010 |
October 2010 |
December 1, 2009 |
October 21, 2010 |
|
- Institute for Nutritional Sciences, Chinese Academy of Sciences
Shanghai, China
|
| 41 |
NCT00742742 |
Completed |
Walnut Intervention on Metabolic Syndrome (WIMS) |
|
- Behavioral: healthy life style education
|
Interventional |
Phase 2
Phase 3 |
- Chinese Academy of Sciences
- California Walnut Commission
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Metabolic syndrome status
- Total cholesterol, triglyceride, LDL_C HDL-C, fasting glucose and insulin, HbA1C, blood pressure, CRP, IL-6, adiponectin, RBP4, E-selectin, ICAM-1, VCAM-1, and fatty acid profiles of the red blood cells.
|
189 |
All |
35 Years to 60 Years (Adult) |
NCT00742742 |
CWC-2008
KSCX1-YW-02 |
WIMS |
March 2009 |
July 2009 |
December 2009 |
August 28, 2008 |
February 5, 2015 |
|
- Institute for Nutritional Sciecnes, Chinese Acadamy of Sciences
Shanghai, China
|
| 42 |
NCT00733772 |
Completed |
Flaxseed Intervention on Metabolic Syndrome |
|
- Dietary Supplement: flaxseed
- Behavioral: Health lifestyle counseling
|
Interventional |
Phase 2
Phase 3 |
- Chinese Academy of Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Metabolic syndrome status
- Total cholesterol, triglyceride, HDL-C,LDL-c, fasting glucose and insulin, HbA1C, blood pressure, CRP, IL-6, adiponectin, RBP-4, E-selectin, ICAM-1, VCAM-1, and fatty acid profiles of red blood cells.
|
189 |
All |
35 Years to 60 Years (Adult) |
NCT00733772 |
KSCX1-YW-02 |
FIMS |
March 2009 |
July 2009 |
December 2009 |
August 13, 2008 |
February 5, 2015 |
|
- Institute for Nutritional Sciences, Chinese Academy of Sciences
Shanghai, Shanghai, China
|
| 43 |
NCT00716300 |
Unknown † |
High Density Lipoprotein (HDL) Functionality in Metabolic Syndrome |
|
|
Observational |
|
- The University of Western Australia
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
|
30 |
All |
20 Years to 75 Years (Adult, Senior) |
NCT00716300 |
DC-HDL2008 |
|
July 2008 |
June 2009 |
December 2009 |
July 16, 2008 |
February 18, 2009 |
|
- University of Western Australia
Perth, Western Australia, Australia
|
| 44 |
NCT00608465 |
Terminated
Has Results |
Defining Strategies for Improving Endothelial and Fibrinolytic Dysfunction in Obesity |
|
- Drug: Eplerenone
- Drug: Ramipril
|
Interventional |
Phase 4 |
- Vanderbilt University
- Vanderbilt University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Secreted Factors From Adipocytes Have Autocrine, Paracrine and Endocrine Effects That Have a Deleterious Effect on the Fibrinolytic System, Either by Enhancing PAI-1 Production or Impairing Endothelial t-PA Release
- This Study Will Analyze Patients' Genetic Make up to Identify Who May be at Greater Risk for Heart Disease and Strokes in Relationship to High Blood Pressure and Central Obesity.
|
4 |
All |
18 Years and older (Adult, Senior) |
NCT00608465 |
060369 |
|
May 2006 |
May 2009 |
May 2011 |
February 6, 2008 |
August 11, 2017 |
May 1, 2017 |
- Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
| 45 |
NCT00400231 |
Completed |
The Fenofibrate and Metformin for Atherogenic Dyslipidemia (FAMA) Study |
|
- Drug: Study drugs: Metformin and fenofibrate
- Drug: Study Drug: Metformin
- Drug: Study Drug: fenofibrate
- Drug: Metformin and Fenofibrate placebo
|
Interventional |
Phase 2 |
- University of Pennsylvania
- Abbott
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Diagnostic
|
- triglyceride levels
- HDL-C, Resistin, insulin resistance
|
124 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00400231 |
800860 |
|
August 2005 |
December 2007 |
March 2008 |
November 16, 2006 |
March 20, 2017 |
|
- University of Pennsylvania
Philadelphia, Pennsylvania, United States
|
| 46 |
NCT00515476 |
Completed |
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study) |
|
- Behavioral: physical exercise
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Primary: vasculoprotective and regenerative functions of HDL-Cholesterol and EPC function before and after 8-weeks exercise training
- Secondary: flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound
|
24 |
All |
21 Years to 75 Years (Adult, Senior) |
NCT00515476 |
4031215 |
HERMET |
June 2007 |
November 2008 |
December 2008 |
August 13, 2007 |
June 23, 2010 |
|
- Hannover Medical School
Hannover, Germany
|
| 47 |
NCT00489333 |
Completed |
ProAlgaZyme Novel Algae Infusion: Applications in Metabolic Syndrome |
|
|
Interventional |
Not Applicable |
- Health Enhancement Products, Inc.
- University of Yaounde
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- hsCRP
- Lipids (total cholesterol, triglycerides HDL-C, LDL-C)
- Anthropometric measurements (weight/BMI, % body fat, blood pressure)
- (and 5 more...)
|
52 |
All |
25 Years to 60 Years (Adult) |
NCT00489333 |
H-0001-01
087/2006 |
|
May 2006 |
|
September 2006 |
June 21, 2007 |
June 21, 2007 |
|
- Laboratory of Nutrition and Nutritional Biochemistry (LNNB), Department of Biochemistry, University of Yaounde I
Yaounde, Cameroon
|
| 48 |
NCT00395486 |
Completed
Has Results |
ROMEO (Rosuvastatin in Metabolic syndrOme) |
|
- Drug: Rosuvastatin
- Drug: Atorvastatin
|
Interventional |
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percentage Change From Baseline in Ratio of Apolipoprotein (ApoB/ApoA1) at Week 6
- Percentage of Subjects Reaching Their LDL-C Target Goal
- Percentage of Subjects Reaching Their Low-Density Lipoprotein-C (LDL-C) and Non High-Density Lipoprotein-C (HDL-C) Target Goal
- (and 9 more...)
|
258 |
All |
18 Years and older (Adult, Senior) |
NCT00395486 |
D3560L00061
ROMEO |
|
September 2006 |
June 2008 |
June 2008 |
November 3, 2006 |
July 11, 2011 |
June 16, 2011 |
- Research Site
Pusan, Korea, Republic of - Research Site
Seoul, Korea, Republic of - Research Site
Suwon, Korea, Republic of
|
| 49 |
NCT00264667 |
Completed |
Study In Patients With Dyslipidaemia |
|
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- Percentage change from baseline in non-HDL-C based on log-transformed data at week 24.
- Percentage change from baseline in lipids, in Homeostasis Model Assessment-insulin sensitivity (HOMA-S), C-Reactive Protein (CRP), Fasting Plasma Glucose (FPG), body weight and waist circumference.
|
290 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT00264667 |
ADG103440 |
|
December 2005 |
|
June 2007 |
December 13, 2005 |
October 28, 2016 |
|
- GSK Investigational Site
Cordoba, Córdova, Argentina - GSK Investigational Site
Córdoba, Córdova, Argentina - GSK Investigational Site
Buenos Aires, Argentina - (and 48 more...)
|
| 50 |
NCT00350194 |
Unknown † |
The Effects of Omega-3 Fatty Acids on Metabolic Syndrome |
|
- Dietary Supplement: Omega-3 fatty acids
|
Interventional |
Early Phase 1 |
- University of Washington
- Pfizer
- National Institutes of Health (NIH)
- Northwest Lipid Research Clinic
|
Other / Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Carotid IMT
- Lipid (apolipoproteins and lipid parameters)
- hs-CRP & SAA
- (and 5 more...)
|
100 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00350194 |
28791-D
05-8693-D 03 |
|
October 2006 |
October 2011 |
June 2012 |
July 10, 2006 |
March 2, 2012 |
|
- Northwest Lipid Research Clinic (University of Washington Affiliated)
Seattle, Washington, United States
|
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