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History of Changes for Study: NCT05265546
Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
Latest version (submitted July 26, 2022) on ClinicalTrials.gov
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Study Record Versions
Version A B Submitted Date Changes
1 March 2, 2022 None (earliest Version on record)
2 July 26, 2022 Arms and Interventions, Study Status, Outcome Measures and Eligibility
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Study NCT05265546
Submitted Date:  March 2, 2022 (v1)

Open or close this module Study Identification
Unique Protocol ID: 2021-11-14799
Brief Title: Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
Official Title: Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
Secondary IDs:
Open or close this module Study Status
Record Verification: February 2022
Overall Status: Not yet recruiting
Study Start: May 1, 2022
Primary Completion: December 31, 2025 [Anticipated]
Study Completion: December 31, 2025 [Anticipated]
First Submitted: February 22, 2022
First Submitted that
Met QC Criteria:
March 2, 2022
First Posted: March 3, 2022 [Actual]
Last Update Submitted that
Met QC Criteria:
March 2, 2022
Last Update Posted: March 3, 2022 [Actual]
Open or close this module Sponsor/Collaborators
Sponsor: University of California, Berkeley
Responsible Party: Sponsor
Collaborators:
Open or close this module Oversight
U.S. FDA-regulated Drug: Yes
U.S. FDA-regulated Device: No
Data Monitoring:
Open or close this module Study Description
Brief Summary: The long-term objective of this project is to characterize how psilocybin affects visual perception and the brain's representation of the visual environment. We know that psilocybin alters aspects of visual perception, but the underlying brain mechanisms contributing to these effects are poorly understood. The proposed work will address these questions in a large, diverse sample of healthy human subjects by using functional magnetic resonance imaging (fMRI) to measure the brain's responses to visual stimuli. The proposed research will document which brain areas mediate the effects of psilocybin. The technique of fMRI will be employed to measure brain activity in different brain areas while subjects are performing a visual perceptual task.
Detailed Description:
Open or close this module Conditions
Conditions: Perception Disorders
Keywords:
Open or close this module Study Design
Study Type: Interventional
Primary Purpose: Basic Science
Study Phase: Phase 1
Interventional Study Model: Crossover Assignment
Number of Arms: 2
Masking: Double (Participant, Investigator)
Allocation: Randomized
Enrollment: 80 [Anticipated]
Open or close this module Arms and Interventions
Arms Assigned Interventions
Experimental: Experimental
Psilocybin (2 mg, 4 mg, 10 mg, or 14 mg), one time before fMRI measurement
Drug: Psilocybin
The effects of psilocybin will be compared to placebo.
Placebo Comparator: Placebo Comparator
Placebo, one time before fMRI measurement
Drug: Psilocybin
The effects of psilocybin will be compared to placebo.
Open or close this module Outcome Measures
Primary Outcome Measures:
1. Amplitude and pattern of fMRI cortical responses
[ Time Frame: Functional MRI recordings will begin approximately 30 minutes after oral administration of psilocybin or placebo and will continue for up to two hours. ]

Functional magnetic resonance imaging (fMRI) responses to visual stimuli will be recorded.
Open or close this module Eligibility
Minimum Age: 21 Years
Maximum Age:
Sex: All
Gender Based:
Accepts Healthy Volunteers: Yes
Criteria:

Inclusion Criteria:

  1. Are ≥21 years of age at time of Informed Consent Form signing
  2. Are able and willing to adhere to study requirements, including attending all study visits, preparatory and follow-up sessions, and completing all study evaluations.
  3. Are able to swallow capsules.
  4. Women of childbearing potential (WOCBP) must agree to practice an effective means of birth control throughout the duration of the study.
  5. Written informed consent obtained from and ability for subject to comply with the requirements of the study.
  6. Have an identified support person and agree to be accompanied home (or to an otherwise safe destination) by the support person, or another responsible party, following dosing.
  7. Agree to inform the investigators within 48 hours of any new or changed medical conditions during the course of their study participation.

Exclusion Criteria:

  1. Breastfeeding, have a positive pregnancy test at screening or at any point during the course of the study, or unwilling to practice birth control during participation in the study.
  2. Have a current psychiatric disorder, general medical condition, or other problem or abnormality that, in the opinion of the study clinician or PI, could compromise safety, render them unsuitable for the study, or would make them unable to comply with study activities.
  3. Have MRI contraindications (e.g., metal implants, pacemakers, claustrophobia etc.) as determined by an MRI contraindications questionnaire.
  4. Have a history of a psychotic disorder (>1 month in duration), bipolar disorder (type I or II), or a dissociative disorder (determined by history).
  5. Family history (first degree relative) of primary psychotic disorder, primary bipolar disorder, or hallucinogen-induced psychotic disorder, if participant < 30 years old.
  6. History of Hallucinogen Persisting Perception Disorder (HPPD).
  7. History of a seizure disorder in adulthood, CNS metastases or current symptomatic CNS infection.
  8. History of intracerebral hemorrhage, embolic stroke, transient ischemic attack (TIA), or history of any aneurysmal vascular disease (including thoracic and abdominal aorta, intracranial and peripheral arterial vessels) or arteriovenous malformation.
  9. Uncontrolled hypertension (Systolic BP>139mmHG or Diastolic BP>89mmHG) or tachycardia (average HR>90bpm) averaged over at least two measurements.
  10. Clinically significant cardiovascular disease (e.g., history of myocardial infarction or congestive heart failure); or baseline QT/QTc>500msec; or baseline QT/QTc 451-500msec with repeat QT/QTc >500msec.
  11. Poorly controlled diabetes mellitus (e.g., history of an episode of severe hypoglycemia or hospitalization for hyperglycemia on the current diabetes regimen).
  12. Inadequate hepatic function as determined by total bilirubin or alkaline phosphatase >3x institutional upper limit of normal; or AST or ALT >6x institutional upper limit of normal. However, participants with Gilbert syndrome are allowed to enroll.
  13. Inadequate renal function as determined by eGFR < 30 mL/min/1.73 m2 (based on the MDRD equation) or CrCl < 30 mL/min (based on the C-G equation).
  14. The regular use of psychotropic medications, such as antidepressants (i.e., SSRIs, tricyclic antidepressants, and monoamine oxidase inhibitors), antipsychotics, and mood stabilizers.
  15. Concomitant dosing of psilocybin with known UGT1A10 and UGT1A9 inhibitors (e.g., diclofenac and probenecid) will be avoided. [There is no exclusion criterion based on the use of medications or substances that are inhibitors or inducers of CYP450 enzymes.]
  16. The use of Prohibited Medications:

    Serotonin Reuptake Inhibitors (SSRIs and SNRIs) Tricyclic Antidepressants (TCAs) Monoamine Oxidase Inhibitors (MAOIs) Atypical antidepressants (e.g., mirtazapine, trazodone, buspar) Antipsychotics/Neuroleptics (typical and atypical) Anti-epileptics or mood stabilizers (e.g., lithium, valproate) (does not include gabapentin used for non-epilepsy conditions) Efavirenz (Sustiva, in Atripla) Lorcaserin Over-the-counter supplements intended to affect mood or anxiety (e.g., 5HT-P, SAMe or St. John's Wort).

    Other drugs associated with the serotonin syndrome (e.g., ondansetron) used within 48 hours of study drug administration (70).

    Vasoactive drugs (e.g., sildenafil, sumatriptan, calcium channel blockers) used within 48 hours of study drug administration.

  17. Unable to agree to the following required Lifestyle Modifications: Patients will be asked to refrain from consuming alcohol, cannabinoids, prescription analgesics/stimulants/benzodiazepines, and any recreational drugs for 48 hours before, the day of, and for 48 hours after study drug administration. Participants will be advised to consume their usual amount of coffee, tea, or other caffeine-containing beverages on the morning of their Medication Visits.
  18. Have a recent history of suicidal ideation or attempted suicide that, in the opinion of the study clinician or PI, may present a risk of suicidal or self-injurious behavior
  19. Have received an investigational drug or taken a psychedelic within 30 days of the screening visit
  20. Have an allergy or intolerance to any of the materials contained in the investigational drug product
Open or close this module Contacts/Locations
Locations: United States, California
University of California, Berkeley
Berkeley, California, United States, 94720
Open or close this module IPDSharing
Plan to Share IPD:
Open or close this module References
Citations:
Links:
Available IPD/Information:

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